TTC21A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.96803628
2cell-cell recognition (GO:0009988)9.95311117
3plasma membrane fusion (GO:0045026)9.56429200
4motile cilium assembly (GO:0044458)9.42445664
5regulation of cilium movement (GO:0003352)9.07983816
6spermatid development (GO:0007286)9.02915446
7reproduction (GO:0000003)8.90076504
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.29668323
9piRNA metabolic process (GO:0034587)7.53848569
10male meiosis (GO:0007140)7.49159229
11single fertilization (GO:0007338)7.33169744
12synaptonemal complex organization (GO:0070193)7.18639915
13sperm capacitation (GO:0048240)6.97719978
14negative regulation of inclusion body assembly (GO:0090084)6.85909711
15synaptonemal complex assembly (GO:0007130)6.83871457
16fertilization (GO:0009566)6.28224512
17ventricular system development (GO:0021591)6.25004002
18spermatogenesis (GO:0007283)6.24788814
19male gamete generation (GO:0048232)6.22253438
20gamete generation (GO:0007276)5.72616430
21organic cation transport (GO:0015695)5.70676847
22regulation of inclusion body assembly (GO:0090083)5.58755365
23microtubule severing (GO:0051013)5.40625337
24regulation of microtubule-based movement (GO:0060632)5.36599943
25microtubule depolymerization (GO:0007019)5.29339242
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.17458863
27axoneme assembly (GO:0035082)5.17265492
28germ cell development (GO:0007281)5.09381015
29male meiosis I (GO:0007141)5.02642015
30calcium ion-dependent exocytosis (GO:0017156)4.98798760
31cell recognition (GO:0008037)4.86963025
32DNA methylation involved in gamete generation (GO:0043046)4.71522905
33chromosome organization involved in meiosis (GO:0070192)4.65009990
34left/right pattern formation (GO:0060972)4.64175676
35spermatid nucleus differentiation (GO:0007289)4.57742124
36multicellular organismal reproductive process (GO:0048609)4.53470306
37protein localization to cilium (GO:0061512)4.52089105
38primary alcohol catabolic process (GO:0034310)4.48059534
39vitamin transmembrane transport (GO:0035461)4.40029193
40seminiferous tubule development (GO:0072520)4.32367835
41protein polyglutamylation (GO:0018095)4.29518482
42meiotic nuclear division (GO:0007126)4.28513773
43cell projection assembly (GO:0030031)3.97476725
44meiosis I (GO:0007127)3.97059768
45intraciliary transport (GO:0042073)3.96859557
46negative regulation of immunoglobulin mediated immune response (GO:0002890)3.96539850
47negative regulation of B cell mediated immunity (GO:0002713)3.96539850
48ethanol metabolic process (GO:0006067)3.95476562
49chromosome condensation (GO:0030261)3.92123938
50one-carbon compound transport (GO:0019755)3.89971745
51tolerance induction (GO:0002507)3.87862076
52regulation of interleukin-5 production (GO:0032674)3.86076087
53negative regulation of T cell differentiation in thymus (GO:0033085)3.84543255
54DNA packaging (GO:0006323)3.82894506
55diterpenoid biosynthetic process (GO:0016102)3.79453593
56response to xenobiotic stimulus (GO:0009410)3.78095721
57glycerol ether metabolic process (GO:0006662)3.76105530
58cilium organization (GO:0044782)3.69302043
59regulation of germinal center formation (GO:0002634)3.67264370
60cilium morphogenesis (GO:0060271)3.62885320
61nucleoside diphosphate phosphorylation (GO:0006165)3.61027105
62meiotic cell cycle (GO:0051321)3.57899444
63multicellular organismal development (GO:0007275)3.57608438
64genitalia morphogenesis (GO:0035112)3.57264097
65pyrimidine-containing compound transmembrane transport (GO:0072531)3.54835594
66cilium assembly (GO:0042384)3.49287876
67microtubule-based movement (GO:0007018)3.47535979
68ether metabolic process (GO:0018904)3.46591955
69GTP biosynthetic process (GO:0006183)3.42268268
70chaperone-mediated protein complex assembly (GO:0051131)3.41739535
71cellular component assembly involved in morphogenesis (GO:0010927)3.33698353
72positive regulation of tolerance induction (GO:0002645)3.30186958
73regulation of interleukin-13 production (GO:0032656)3.26423609
74monoubiquitinated protein deubiquitination (GO:0035520)3.25804703
75phosphatidylethanolamine biosynthetic process (GO:0006646)3.25458928
76phosphatidylethanolamine metabolic process (GO:0046337)3.24357207
77lateral ventricle development (GO:0021670)3.24191231
78regulation of spindle checkpoint (GO:0090231)3.21852767
79glomerular epithelial cell development (GO:0072310)3.19277143
80nonmotile primary cilium assembly (GO:0035058)3.14959592
81left/right axis specification (GO:0070986)3.14864690
82lung epithelium development (GO:0060428)3.12747689
83cytoplasmic microtubule organization (GO:0031122)3.11715925
84negative regulation of organelle assembly (GO:1902116)3.07147377
85negative regulation of humoral immune response (GO:0002921)3.05861054
86protein refolding (GO:0042026)3.04309852
87photoreceptor cell maintenance (GO:0045494)3.03856000
88establishment of planar polarity (GO:0001736)3.03430291
89establishment of tissue polarity (GO:0007164)3.03430291
90UTP biosynthetic process (GO:0006228)3.01644912
91retinal rod cell development (GO:0046548)2.96353087
92sexual reproduction (GO:0019953)2.96041186
93amino-acid betaine transport (GO:0015838)2.94800579
94carnitine transport (GO:0015879)2.94800579
95ethanol oxidation (GO:0006069)2.94586857
96retinoic acid metabolic process (GO:0042573)2.90693525
97negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.87533682
98regulation of cilium assembly (GO:1902017)2.87029431
99carnitine transmembrane transport (GO:1902603)2.86623905
100establishment or maintenance of monopolar cell polarity (GO:0061339)2.84089888
101establishment of monopolar cell polarity (GO:0061162)2.84089888
102positive regulation of macrophage activation (GO:0043032)2.82783309
103smoothened signaling pathway (GO:0007224)2.78211111
104microtubule bundle formation (GO:0001578)2.77067729
105synapsis (GO:0007129)2.76369591
106nucleus organization (GO:0006997)2.75192938
107UTP metabolic process (GO:0046051)2.74770741
108glycolytic process (GO:0006096)2.74093252
109protein K11-linked deubiquitination (GO:0035871)2.73678686
110interferon-gamma secretion (GO:0072643)2.73221315
111peptidyl-glutamic acid modification (GO:0018200)2.73019076
112meiotic cell cycle process (GO:1903046)2.73016468
113gene silencing by RNA (GO:0031047)2.72151338
114regulation of collateral sprouting (GO:0048670)2.71371796
115phosphatidylcholine biosynthetic process (GO:0006656)2.70832321
116centriole assembly (GO:0098534)2.67942736
117determination of left/right symmetry (GO:0007368)2.66312977
118sequestering of actin monomers (GO:0042989)2.65484536
119lactate metabolic process (GO:0006089)2.65430220
120mitotic sister chromatid cohesion (GO:0007064)2.64191551
121single strand break repair (GO:0000012)2.63399149
122hydrogen peroxide biosynthetic process (GO:0050665)2.63188167
123regulation of tolerance induction (GO:0002643)2.59174735
124regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.59137012
125establishment of apical/basal cell polarity (GO:0035089)2.56365929
126microtubule-based process (GO:0007017)2.53810852
127polyol catabolic process (GO:0046174)2.52643829
128microtubule polymerization or depolymerization (GO:0031109)2.50242264
129determination of bilateral symmetry (GO:0009855)2.48842568
130exogenous drug catabolic process (GO:0042738)2.48830010
131organelle assembly (GO:0070925)2.48759349
132terpenoid biosynthetic process (GO:0016114)2.48208097
133negative regulation of skeletal muscle tissue development (GO:0048642)2.47289910
134centriole replication (GO:0007099)2.45963868
135RNA localization (GO:0006403)2.45534880
136mitochondrion degradation (GO:0000422)2.44434930
137reactive oxygen species biosynthetic process (GO:1903409)2.40015757
138specification of symmetry (GO:0009799)2.39811751
139retinal cone cell development (GO:0046549)2.37246376
140excretion (GO:0007588)2.34770442
141positive regulation of smoothened signaling pathway (GO:0045880)2.32194631
142glutathione derivative metabolic process (GO:1901685)2.30683325
143glutathione derivative biosynthetic process (GO:1901687)2.30683325
144brain morphogenesis (GO:0048854)2.29672969
145establishment of protein localization to Golgi (GO:0072600)2.28167714
146sialylation (GO:0097503)2.24336425
147embryonic body morphogenesis (GO:0010172)2.21976085
148drug catabolic process (GO:0042737)2.20988947
149phenol-containing compound catabolic process (GO:0019336)2.20465892
150limb development (GO:0060173)2.19400275
151appendage development (GO:0048736)2.19400275
152fusion of sperm to egg plasma membrane (GO:0007342)12.5522885
153sperm motility (GO:0030317)12.4914266
154cilium or flagellum-dependent cell motility (GO:0001539)12.3907711
155axonemal dynein complex assembly (GO:0070286)11.2728331
156cell wall macromolecule catabolic process (GO:0016998)11.2492240
157cell wall macromolecule metabolic process (GO:0044036)11.2492240
158acrosome reaction (GO:0007340)11.1820204
159acrosome assembly (GO:0001675)11.1662911
160sperm-egg recognition (GO:0035036)11.1207926
161multicellular organism reproduction (GO:0032504)10.5980088
162epithelial cilium movement (GO:0003351)10.4847860
163binding of sperm to zona pellucida (GO:0007339)10.0162814

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.70416725
2EZH2_22144423_ChIP-Seq_EOC_Human4.61031773
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50370003
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.68935174
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.50077056
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.12585630
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.77642724
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63474981
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32246140
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.27416027
11CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.95006569
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94374658
13VDR_22108803_ChIP-Seq_LS180_Human1.91046454
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.81724521
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.80248364
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77779933
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.77394889
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.75236984
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74082597
20ZNF274_21170338_ChIP-Seq_K562_Hela1.71728694
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.71698598
22STAT1_17558387_ChIP-Seq_HELA_Human1.67035583
23MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.63007704
24ARNT_22903824_ChIP-Seq_MCF-7_Human1.62286120
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61813272
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.56709881
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55727733
28AHR_22903824_ChIP-Seq_MCF-7_Human1.54695236
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.53563474
30AR_21572438_ChIP-Seq_LNCaP_Human1.42301354
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42083426
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41822310
33GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41721899
34GATA3_21867929_ChIP-Seq_CD8_Mouse1.40756636
35CBP_20019798_ChIP-Seq_JUKART_Human1.40746590
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40746590
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40669759
38SMRT_27268052_Chip-Seq_Bcells_Human1.40386738
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39860696
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.39745990
41KDM2B_26808549_Chip-Seq_REH_Human1.38169560
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37465942
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.36406737
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.36217421
45TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34292618
46* TAL1_26923725_Chip-Seq_HPCs_Mouse1.33854581
47TDRD3_21172665_ChIP-Seq_MCF-7_Human1.33758121
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.32346864
49SMAD4_21799915_ChIP-Seq_A2780_Human1.31658973
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27528881
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.27020505
52STAT3_23295773_ChIP-Seq_U87_Human1.26534097
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26360897
54ETV1_20927104_ChIP-Seq_GIST48_Human1.26340758
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25783071
56* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.25122392
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24961113
58SMC4_20622854_ChIP-Seq_HELA_Human1.24673134
59GF1_26923725_Chip-Seq_HPCs_Mouse1.24334512
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24006115
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24006115
62STAT1_20625510_ChIP-Seq_HELA_Human1.22994837
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22775695
64REST_21632747_ChIP-Seq_MESCs_Mouse1.22703655
65FLI1_21867929_ChIP-Seq_TH2_Mouse1.22594072
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22402666
67P53_21459846_ChIP-Seq_SAOS-2_Human1.22238314
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.21803867
69SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20916719
70CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20521416
71ER_23166858_ChIP-Seq_MCF-7_Human1.20502646
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19682733
73CTCF_27219007_Chip-Seq_Bcells_Human1.18499663
74FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17695408
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16519229
76GATA3_21867929_ChIP-Seq_TH1_Mouse1.16456519
77FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14436919
78BCAT_22108803_ChIP-Seq_LS180_Human1.14067123
79SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12693327
80TP63_23658742_ChIP-Seq_EP156T_Human1.12395549
81RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12249168
82* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11364355
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10589159
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.10327388
85TCF4_23295773_ChIP-Seq_U87_Human1.09867313
86NANOG_18555785_Chip-Seq_ESCs_Mouse1.09042426
87GBX2_23144817_ChIP-Seq_PC3_Human1.08802234
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.08606680
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.08331709
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08194322
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.08165256
92* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07926647
93OCT4_18555785_Chip-Seq_ESCs_Mouse1.07781201
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07320244
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.07097635
96TP63_22573176_ChIP-Seq_HFKS_Human1.06822145
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.06618659
98HNFA_21074721_ChIP-Seq_CACO-2_Human1.05687749
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05486606
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05400231
101RNF2_27304074_Chip-Seq_NSC_Mouse1.04896711
102* AR_25329375_ChIP-Seq_VCAP_Human1.04796353
103RUNX2_22187159_ChIP-Seq_PCA_Human1.04285453
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04130467
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04090777
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03778278
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03427628
108PHF8_20622853_ChIP-Seq_HELA_Human1.03407727
109CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03096646
110MYC_19829295_ChIP-Seq_ESCs_Human1.02827802
111P53_22387025_ChIP-Seq_ESCs_Mouse1.02479028
112TBL1_22424771_ChIP-Seq_293T_Human1.02288226
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02187734
114RBPJ_21746931_ChIP-Seq_IB4_Human1.01825063
115ERA_21632823_ChIP-Seq_H3396_Human1.01320844
116CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01117900
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00755301
118JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00093740
119TP53_18474530_ChIP-ChIP_U2OS_Human0.99838573
120OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98990301
121OCT4_20526341_ChIP-Seq_ESCs_Human0.98764415
122FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98459466
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.98459466
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.98136613
125SPI1_26923725_Chip-Seq_HPCs_Mouse0.98112408
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98057848
127P300_18555785_Chip-Seq_ESCs_Mouse0.97774516
128GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97674368
129ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97654370
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97549623
131ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97306182
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.96684114
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.96683328
134EZH2_27294783_Chip-Seq_NPCs_Mouse0.96140290
135EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95918215
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95649226
137CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95546072
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.95539821
139SMAD4_21741376_ChIP-Seq_HESCs_Human0.95378281
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95185385
141* ERG_20517297_ChIP-Seq_VCAP_Human0.94748183
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94679138
143NFYA_21822215_ChIP-Seq_K562_Human0.94263819
144KLF4_18555785_Chip-Seq_ESCs_Mouse0.94230198
145TAF15_26573619_Chip-Seq_HEK293_Human0.93550228
146TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.92739959
147GATA6_21074721_ChIP-Seq_CACO-2_Human0.92347133
148MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92111048
149CEBPB_22108803_ChIP-Seq_LS180_Human0.91992086
150NFYB_21822215_ChIP-Seq_K562_Human0.91928459
151P300_19829295_ChIP-Seq_ESCs_Human0.91758003
152DROSHA_22980978_ChIP-Seq_HELA_Human0.91554403
153* TCF4_22108803_ChIP-Seq_LS180_Human0.91523394
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.90850806
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90841267
156ELF1_20517297_ChIP-Seq_JURKAT_Human0.90728541
157SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90298708
158TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90283813
159SMAD3_21741376_ChIP-Seq_ESCs_Human0.90251285
160CTCF_20526341_ChIP-Seq_ESCs_Human0.90226831
161* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90151887
162NCOR_22424771_ChIP-Seq_293T_Human0.89716312
163CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88880230
164AR_19668381_ChIP-Seq_PC3_Human0.88797675
165KLF5_25053715_ChIP-Seq_YYC3_Human0.88678820
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88620441
167SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88368895
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.88159529
169RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88121615
170ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87870210
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87670913
172PU1_27457419_Chip-Seq_LIVER_Mouse0.87611398
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87592959
174RARA_24833708_ChIP-Seq_LIVER_Mouse0.87371094
175GF1B_26923725_Chip-Seq_HPCs_Mouse0.86684393
176MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86137963
177NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85945714
178PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85758136
179CTCF_18555785_Chip-Seq_ESCs_Mouse0.85371970

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.69777885
2MP0001929_abnormal_gametogenesis5.16138227
3MP0008877_abnormal_DNA_methylation4.14087924
4MP0002653_abnormal_ependyma_morphology3.98568789
5MP0002210_abnormal_sex_determination3.27928112
6MP0002161_abnormal_fertility/fecundity3.09912524
7MP0004043_abnormal_pH_regulation3.06933489
8MP0001984_abnormal_olfaction2.93685149
9MP0001145_abnormal_male_reproductive2.78356269
10MP0005623_abnormal_meninges_morphology2.49684532
11MP0002277_abnormal_respiratory_mucosa2.46052708
12MP0000653_abnormal_sex_gland2.44331537
13MP0005377_hearing/vestibular/ear_phenot2.33910597
14MP0003878_abnormal_ear_physiology2.33910597
15MP0005670_abnormal_white_adipose2.23600084
16MP0005410_abnormal_fertilization15.2564204
17MP0002160_abnormal_reproductive_system1.94525551
18MP0008995_early_reproductive_senescence1.63336420
19MP0000383_abnormal_hair_follicle1.55635251
20MP0002282_abnormal_trachea_morphology1.53177688
21MP0004019_abnormal_vitamin_homeostasis1.49771327
22MP0002735_abnormal_chemical_nociception1.48812701
23MP0002909_abnormal_adrenal_gland1.47903754
24MP0005083_abnormal_biliary_tract1.46280754
25MP0006276_abnormal_autonomic_nervous1.40689030
26MP0002734_abnormal_mechanical_nocicepti1.39040451
27MP0005310_abnormal_salivary_gland1.36056231
28MP0002638_abnormal_pupillary_reflex1.36012593
29MP0005248_abnormal_Harderian_gland1.33922532
30MP0002138_abnormal_hepatobiliary_system1.33134763
31MP0001970_abnormal_pain_threshold1.32271421
32MP0001790_abnormal_immune_system1.27003568
33MP0005387_immune_system_phenotype1.27003568
34MP0003879_abnormal_hair_cell1.20783110
35MP0009046_muscle_twitch1.13324262
36MP0003890_abnormal_embryonic-extraembry1.12784755
37MP0009780_abnormal_chondrocyte_physiolo1.10116556
38MP0009745_abnormal_behavioral_response1.10004019
39MP0001485_abnormal_pinna_reflex1.08598570
40MP0000678_abnormal_parathyroid_gland1.07172092
41MP0000566_synostosis1.06951115
42MP0002572_abnormal_emotion/affect_behav1.06932030
43MP0002272_abnormal_nervous_system1.06931751
44MP0001502_abnormal_circadian_rhythm1.04239130
45MP0000955_abnormal_spinal_cord1.02028817
46MP0003646_muscle_fatigue0.98504789
47MP0002837_dystrophic_cardiac_calcinosis0.97054419
48MP0001765_abnormal_ion_homeostasis0.96265639
49MP0004859_abnormal_synaptic_plasticity0.95232618
50MP0002928_abnormal_bile_duct0.94027633
51MP0004233_abnormal_muscle_weight0.92517965
52MP0001968_abnormal_touch/_nociception0.92343185
53MP0005389_reproductive_system_phenotype0.91444577
54MP0003011_delayed_dark_adaptation0.88099703
55MP0002733_abnormal_thermal_nociception0.86046331
56MP0010678_abnormal_skin_adnexa0.85715344
57MP0008058_abnormal_DNA_repair0.85357148
58MP0002067_abnormal_sensory_capabilities0.84726314
59MP0004885_abnormal_endolymph0.82915432
60MP0002876_abnormal_thyroid_physiology0.82599189
61MP0003115_abnormal_respiratory_system0.81937974
62MP0005395_other_phenotype0.81600746
63MP0003880_abnormal_central_pattern0.76699564
64MP0008004_abnormal_stomach_pH0.76479065
65MP0000778_abnormal_nervous_system0.75799202
66MP0003656_abnormal_erythrocyte_physiolo0.73509153
67MP0003635_abnormal_synaptic_transmissio0.73279721
68MP0009765_abnormal_xenobiotic_induced0.72187304
69MP0002063_abnormal_learning/memory/cond0.71506067
70MP0002136_abnormal_kidney_physiology0.70703554
71MP0009278_abnormal_bone_marrow0.69471964
72MP0005365_abnormal_bile_salt0.69295788
73MP0004742_abnormal_vestibular_system0.68915651
74MP0005647_abnormal_sex_gland0.68229632
75MP0005397_hematopoietic_system_phenotyp0.68064018
76MP0001545_abnormal_hematopoietic_system0.68064018
77MP0001835_abnormal_antigen_presentation0.68000003
78MP0005394_taste/olfaction_phenotype0.67704645
79MP0005499_abnormal_olfactory_system0.67704645
80MP0003950_abnormal_plasma_membrane0.66241890
81MP0010155_abnormal_intestine_physiology0.65826052
82MP0002064_seizures0.65671117
83MP0006082_CNS_inflammation0.65086909
84MP0001501_abnormal_sleep_pattern0.63734420
85MP0001800_abnormal_humoral_immune0.62394827
86MP0004133_heterotaxia0.61403565
87MP0001293_anophthalmia0.61232627
88MP0001663_abnormal_digestive_system0.60664953
89MP0002234_abnormal_pharynx_morphology0.60434700
90MP0002102_abnormal_ear_morphology0.59377661
91MP0005551_abnormal_eye_electrophysiolog0.57148675
92MP0000534_abnormal_ureter_morphology0.55888068
93MP0003787_abnormal_imprinting0.55179867
94MP0001851_eye_inflammation0.54371609
95MP0001486_abnormal_startle_reflex0.53562071
96MP0008789_abnormal_olfactory_epithelium0.52789611
97MP0000026_abnormal_inner_ear0.52211933
98MP0001963_abnormal_hearing_physiology0.49086967
99MP0002405_respiratory_system_inflammati0.49067137
100MP0005253_abnormal_eye_physiology0.48176017
101MP0003786_premature_aging0.47940633
102MP0003942_abnormal_urinary_system0.47582050
103MP0000569_abnormal_digit_pigmentation0.47312069
104MP0003136_yellow_coat_color0.45886847
105MP0008961_abnormal_basal_metabolism0.45379983
106MP0001958_emphysema0.45324952
107MP0005391_vision/eye_phenotype0.45224625
108MP0005388_respiratory_system_phenotype0.44799140
109MP0002133_abnormal_respiratory_system0.44799140
110MP0003045_fibrosis0.42925738
111MP0003699_abnormal_female_reproductive0.42731957
112MP0002132_abnormal_respiratory_system0.41223388
113MP0008057_abnormal_DNA_replication0.41010543
114MP0001324_abnormal_eye_pigmentation0.40995864
115MP0009115_abnormal_fat_cell0.40927046
116MP0010094_abnormal_chromosome_stability0.37869212
117MP0003861_abnormal_nervous_system0.37781868
118MP0003303_peritoneal_inflammation0.36377213
119MP0000358_abnormal_cell_content/0.35699050
120MP0003329_amyloid_beta_deposits0.35370412
121MP0002092_abnormal_eye_morphology0.34806130
122MP0008875_abnormal_xenobiotic_pharmacok0.34217468
123MP0002152_abnormal_brain_morphology0.32139381
124MP0004808_abnormal_hematopoietic_stem0.30411754
125MP0005636_abnormal_mineral_homeostasis0.30156926
126MP0001270_distended_abdomen0.29908139
127MP0003633_abnormal_nervous_system0.29516811
128MP0004811_abnormal_neuron_physiology0.29005228
129MP0002752_abnormal_somatic_nervous0.27899384
130MP0002229_neurodegeneration0.26344773
131MP0002295_abnormal_pulmonary_circulatio0.25962281
132MP0001119_abnormal_female_reproductive0.25158536
133MP0003948_abnormal_gas_homeostasis0.24876951
134MP0005195_abnormal_posterior_eye0.24566542
135MP0005423_abnormal_somatic_nervous0.21790518
136MP0005174_abnormal_tail_pigmentation0.21577914
137MP0003631_nervous_system_phenotype0.20860199
138MP0005167_abnormal_blood-brain_barrier0.20857254
139MP0005666_abnormal_adipose_tissue0.20172277
140MP0000313_abnormal_cell_death0.19963849
141MP0002233_abnormal_nose_morphology0.18512112
142MP0002084_abnormal_developmental_patter0.18350838
143MP0002557_abnormal_social/conspecific_i0.18142432
144MP0010307_abnormal_tumor_latency0.17627173
145MP0002882_abnormal_neuron_morphology0.17411487
146MP0000432_abnormal_head_morphology0.17071897
147MP0002168_other_aberrant_phenotype0.16856434
148MP0001849_ear_inflammation0.16358599
149MP0002169_no_abnormal_phenotype0.15569708
150MP0002873_normal_phenotype0.15203020

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.06661275
2Abnormal respiratory motile cilium morphology (HP:0005938)9.06661275
3Abnormal ciliary motility (HP:0012262)8.48961802
4Rhinitis (HP:0012384)8.16977191
5Chronic bronchitis (HP:0004469)7.33543677
6Nasal polyposis (HP:0100582)6.36178953
7Infertility (HP:0000789)5.93091552
8Abnormality of the nasal mucosa (HP:0000433)5.40339024
9Bronchiectasis (HP:0002110)5.02077456
10Bronchitis (HP:0012387)4.66378717
11Nephronophthisis (HP:0000090)4.58346114
12Male infertility (HP:0003251)4.00297379
13Recurrent sinusitis (HP:0011108)3.57583252
14Abnormality of the renal medulla (HP:0100957)3.51872754
15Recurrent otitis media (HP:0000403)3.31794084
16Abnormality of midbrain morphology (HP:0002418)3.19301726
17Molar tooth sign on MRI (HP:0002419)3.19301726
18Tubulointerstitial nephritis (HP:0001970)3.10228000
19Abnormal spermatogenesis (HP:0008669)3.03213503
20Recurrent bronchitis (HP:0002837)2.88268743
21Chronic otitis media (HP:0000389)2.81410620
22Tubular atrophy (HP:0000092)2.79790981
23Tubulointerstitial abnormality (HP:0001969)2.74494659
24Atelectasis (HP:0100750)2.58542965
25Medial flaring of the eyebrow (HP:0010747)2.52353531
26Tubulointerstitial fibrosis (HP:0005576)2.47584248
27Hyperactive renin-angiotensin system (HP:0000841)2.47147837
28Postaxial foot polydactyly (HP:0001830)2.34954402
29Anencephaly (HP:0002323)2.34923636
30Pancreatic fibrosis (HP:0100732)2.34376728
31Congenital hepatic fibrosis (HP:0002612)2.29347750
32Azoospermia (HP:0000027)2.15178696
33Bile duct proliferation (HP:0001408)2.13210182
34Abnormal biliary tract physiology (HP:0012439)2.13210182
35Male pseudohermaphroditism (HP:0000037)2.12163708
36Impulsivity (HP:0100710)2.10682649
37Facial cleft (HP:0002006)2.08587380
38Median cleft lip (HP:0000161)2.04789967
39True hermaphroditism (HP:0010459)2.04492362
40Stage 5 chronic kidney disease (HP:0003774)2.03489300
41Cystic liver disease (HP:0006706)2.02936399
42Decreased circulating renin level (HP:0003351)2.01350784
43Fibular hypoplasia (HP:0003038)2.01005325
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00663956
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4198579
46Dynein arm defect of respiratory motile cilia (HP:0012255)11.7630823
47Absent/shortened dynein arms (HP:0200106)11.7630823
48Abnormal respiratory motile cilium physiology (HP:0012261)10.0160125
49Hyperkalemia (HP:0002153)1.99217339
50Aplasia/Hypoplasia of the spleen (HP:0010451)1.98658646
51Chronic sinusitis (HP:0011109)1.98256259
52Asplenia (HP:0001746)1.93611999
53Abnormal rod and cone electroretinograms (HP:0008323)1.90988176
54Decreased central vision (HP:0007663)1.89281572
55Gonadotropin excess (HP:0000837)1.87387603
56Abnormal drinking behavior (HP:0030082)1.87021922
57Polydipsia (HP:0001959)1.87021922
58Abnormality of the renal cortex (HP:0011035)1.79493592
59Oculomotor apraxia (HP:0000657)1.77602987
60Dyschromatopsia (HP:0007641)1.75418173
61Renal salt wasting (HP:0000127)1.75331424
62Postaxial hand polydactyly (HP:0001162)1.75278488
63Abnormality of dentin (HP:0010299)1.74811662
64Short ribs (HP:0000773)1.73837856
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.72643340
66Cone-rod dystrophy (HP:0000548)1.71954039
67Abnormality of the dental root (HP:0006486)1.71625678
68Taurodontia (HP:0000679)1.71625678
69Abnormality of permanent molar morphology (HP:0011071)1.71625678
70Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69973715
71Sclerocornea (HP:0000647)1.67071518
72Renal dysplasia (HP:0000110)1.64803428
73J-shaped sella turcica (HP:0002680)1.64134457
74Abnormality of renal excretion (HP:0011036)1.64094748
75Cholecystitis (HP:0001082)1.62862199
76Abnormal gallbladder physiology (HP:0012438)1.62862199
77Bony spicule pigmentary retinopathy (HP:0007737)1.62452262
78Abnormality of the lower motor neuron (HP:0002366)1.62053281
79Abnormality of molar (HP:0011077)1.60797824
80Abnormality of molar morphology (HP:0011070)1.60797824
81Abnormality of chloride homeostasis (HP:0011422)1.59907626
82Occipital encephalocele (HP:0002085)1.59721083
83Furrowed tongue (HP:0000221)1.59251838
84Retinitis pigmentosa (HP:0000510)1.58210754
85Absent frontal sinuses (HP:0002688)1.57439714
86Abnormality of the dental pulp (HP:0006479)1.55906238
87Bell-shaped thorax (HP:0001591)1.54067088
88Choroideremia (HP:0001139)1.53910608
89Pancreatic cysts (HP:0001737)1.52432658
90Congenital primary aphakia (HP:0007707)1.50864468
91Gait imbalance (HP:0002141)1.50430413
92Hyperaldosteronism (HP:0000859)1.49171757
93Spastic tetraparesis (HP:0001285)1.47059197
94Abnormality of macular pigmentation (HP:0008002)1.46449777
95Aplasia/Hypoplasia of the lens (HP:0008063)1.45267794
96Heterotopia (HP:0002282)1.44557582
97Microglossia (HP:0000171)1.43713593
98Deformed sella turcica (HP:0002681)1.43700002
99Chronic hepatic failure (HP:0100626)1.41930375
100Short thorax (HP:0010306)1.41494793
101Nephropathy (HP:0000112)1.40237214
102Abnormality of renin-angiotensin system (HP:0000847)1.38498006
103Absent epiphyses (HP:0010577)1.38276021
104Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.38276021
105Supernumerary spleens (HP:0009799)1.38258912
106Genital tract atresia (HP:0001827)1.35996149
107Abnormal urine output (HP:0012590)1.34574946
108Amyotrophic lateral sclerosis (HP:0007354)1.33315493
109Broad distal phalanx of finger (HP:0009836)1.27909217
110Neurofibrillary tangles (HP:0002185)1.27558701
111Severe visual impairment (HP:0001141)1.27489275
112Nephrogenic diabetes insipidus (HP:0009806)1.27208400
113Vaginal atresia (HP:0000148)1.25576609
114Abnormality of saccadic eye movements (HP:0000570)1.24051497
115Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22298440
116Narrow forehead (HP:0000341)1.21398711
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.21310273
118Absent speech (HP:0001344)1.20382081
119Prominent nasal bridge (HP:0000426)1.20088718
120Hypokalemic alkalosis (HP:0001949)1.19819470
121Hand muscle atrophy (HP:0009130)1.19687359
122Fetal akinesia sequence (HP:0001989)1.19434356
123Bifid tongue (HP:0010297)1.17241625
124Constricted visual fields (HP:0001133)1.15819339
125Poor coordination (HP:0002370)1.14463606
126Impaired proprioception (HP:0010831)1.14268507
127Polyuria (HP:0000103)1.14161927
128Preaxial hand polydactyly (HP:0001177)1.13611566
129Multicystic kidney dysplasia (HP:0000003)1.13017195
130Portal hypertension (HP:0001409)1.11270403
131Lip pit (HP:0100267)1.09551093
132Specific learning disability (HP:0001328)1.07611653
133Hip dysplasia (HP:0001385)1.02476833
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.02388642

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.58556693
2PDK47.58556693
3TESK16.64018636
4PRKD35.19889591
5PDK24.87350706
6ICK4.14120203
7PNCK2.86338307
8PTK2B2.68172223
9MAPK152.51318395
10FRK2.31742138
11WNK42.05937675
12STK392.03370220
13STK381.91114928
14MAP3K21.62678258
15NEK21.58322486
16BCR1.30905540
17DYRK1B1.28990697
18CASK1.26395981
19NTRK31.26215745
20INSRR1.24898303
21BLK1.21943539
22MAP3K71.06960341
23PDK11.01223258
24TLK11.01126396
25STK240.99683731
26DYRK30.96037424
27ADRBK20.95776856
28PAK30.91910245
29MAPK130.91879926
30NME10.90968643
31TYRO30.89649004
32STK160.88806023
33MAP3K40.85310331
34ACVR1B0.84867547
35WNK10.84839961
36STK30.83970650
37TNK20.80815689
38SGK2230.78085480
39SGK4940.78085480
40CAMK1G0.76583853
41IRAK10.74662168
42CDK190.74013119
43CAMKK20.73730681
44SIK20.73609431
45MARK10.72581179
46SGK10.72493435
47LMTK20.72231329
48MAP4K20.71761440
49SGK20.71743860
50TXK0.70333356
51BTK0.69771363
52ERBB20.68704801
53TTK0.68360011
54PRKCI0.66297466
55TBK10.65824645
56EEF2K0.65172111
57RIPK10.63062635
58PDPK10.62559519
59WEE10.61797004
60MAPKAPK30.61687268
61IKBKE0.61371277
62STK38L0.61317596
63EPHA40.60145225
64ADRBK10.57315784
65PASK0.56917516
66PRKAA20.56249233
67CHUK0.55907757
68MATK0.54556578
69NTRK20.52975761
70LRRK20.52211101
71EPHB10.51706463
72MAP3K110.49182345
73PAK40.48969675
74WNK30.48605812
75PRKACA0.47948007
76BRSK20.47556662
77CHEK20.47155915
78HIPK20.45885255
79BMPR1B0.44839499
80IRAK40.44638461
81DYRK1A0.44363980
82MAP2K60.43831375
83MAP2K40.43551380
84MAP4K10.43249025
85PLK20.42740624
86PAK10.42287350
87PRKCH0.42141719
88PRKCD0.41925296
89TAOK10.41700068
90GRK70.40261531
91PAK20.38855885
92CHEK10.38528296
93TEC0.38167643
94TESK20.37596720
95CAMK2A0.36605537
96CAMKK10.36151216
97GRK60.35961089
98CDK50.35771005
99CCNB10.35719870
100MINK10.34904327
101DYRK20.34348088
102CDC70.34341586
103CAMK10.33364810
104GRK10.33268914
105SGK30.33142603
106FYN0.33142261
107CDC42BPA0.33098597
108NEK60.31771189
109TYK20.31430722
110MTOR0.29649193
111MARK20.29028427
112LATS10.28907592
113ATM0.27735645
114STK100.27426355
115ATR0.26978070
116PINK10.26719510
117PRKCG0.25191066
118RIPK40.24550763
119RPS6KA20.24425722
120STK110.23076197
121CDK120.22877591
122MAP2K20.21508564
123DAPK20.21327893
124MAPKAPK50.21008595
125PRKAA10.17826662
126PRKCZ0.17817589
127RPS6KB10.17196759
128RPS6KA10.16327885
129BRSK10.15595121
130MAP3K30.14761568
131MST1R0.14491001
132ZAP700.13975184
133MUSK0.13522442
134IRAK20.12906323
135GSK3A0.12840626
136NLK0.09563758
137AURKA0.09513550
138EPHA20.09201699
139MAP3K100.08730106
140GSK3B0.08555475
141PDGFRB0.08075925
142PLK10.07657149
143CDK30.06938983
144PRKG20.06485584
145CSK0.05945687
146EGFR0.05615441
147PRKCQ0.04994513
148CSNK2A10.03604713
149MAPK80.03590748
150PLK40.03506224
151PKN10.02768284
152MST40.02288454
153PRKG10.02203597
154CLK10.01652128
155PRKACG0.01023085
156CDK20.00909787
157CDK10.00498400
158MAP2K70.00178697
159PTK6-0.0117079
160MAPK1-0.0110100
161CSNK1D-0.0056684
162MAPK10-0.0039510
163CSNK2A2-0.0031448
164PRKDC-0.0018581

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.89853331
2Fatty acid biosynthesis_Homo sapiens_hsa000613.85900082
3Vitamin B6 metabolism_Homo sapiens_hsa007503.18406023
4Phenylalanine metabolism_Homo sapiens_hsa003603.16557068
5Pyruvate metabolism_Homo sapiens_hsa006202.86659059
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.64068378
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51102762
8Glucagon signaling pathway_Homo sapiens_hsa049222.47341001
9Linoleic acid metabolism_Homo sapiens_hsa005912.46201190
10Tyrosine metabolism_Homo sapiens_hsa003502.36311804
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28567552
12Basal transcription factors_Homo sapiens_hsa030222.22761062
13Carbohydrate digestion and absorption_Homo sapiens_hsa049732.17609163
14beta-Alanine metabolism_Homo sapiens_hsa004102.15047217
15Dorso-ventral axis formation_Homo sapiens_hsa043202.09412375
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.99707452
17Pentose phosphate pathway_Homo sapiens_hsa000301.98547568
18Propanoate metabolism_Homo sapiens_hsa006401.96671163
19Olfactory transduction_Homo sapiens_hsa047401.92031752
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80725429
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74339901
22Glycerolipid metabolism_Homo sapiens_hsa005611.71729730
23Selenocompound metabolism_Homo sapiens_hsa004501.67125712
24Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.67040388
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66865601
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.63746524
27Oocyte meiosis_Homo sapiens_hsa041141.61501219
28Fanconi anemia pathway_Homo sapiens_hsa034601.60515299
29Amphetamine addiction_Homo sapiens_hsa050311.60349357
30Nicotine addiction_Homo sapiens_hsa050331.55993909
31PPAR signaling pathway_Homo sapiens_hsa033201.52969167
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.52094594
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.51251501
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50956626
35Mineral absorption_Homo sapiens_hsa049781.47536052
36Ether lipid metabolism_Homo sapiens_hsa005651.33236811
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.33006919
38Huntingtons disease_Homo sapiens_hsa050161.31502680
39Renin secretion_Homo sapiens_hsa049241.31377129
40Glutathione metabolism_Homo sapiens_hsa004801.29839860
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24095467
42Thyroid hormone synthesis_Homo sapiens_hsa049181.22610921
43Fructose and mannose metabolism_Homo sapiens_hsa000511.21866952
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.20557832
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20407065
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17580706
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17180432
48Renin-angiotensin system_Homo sapiens_hsa046141.14707001
49Estrogen signaling pathway_Homo sapiens_hsa049151.12036845
50Allograft rejection_Homo sapiens_hsa053301.09858001
51Caffeine metabolism_Homo sapiens_hsa002321.09470353
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08683343
53Peroxisome_Homo sapiens_hsa041461.05467840
54Autoimmune thyroid disease_Homo sapiens_hsa053201.04820564
55Antigen processing and presentation_Homo sapiens_hsa046121.01680430
56Taste transduction_Homo sapiens_hsa047421.00741777
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00680743
58mRNA surveillance pathway_Homo sapiens_hsa030151.00107495
59Arachidonic acid metabolism_Homo sapiens_hsa005900.99861542
60Fat digestion and absorption_Homo sapiens_hsa049750.99528733
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.97900583
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96698789
63Insulin secretion_Homo sapiens_hsa049110.95980548
64Type I diabetes mellitus_Homo sapiens_hsa049400.94817978
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94159245
66ABC transporters_Homo sapiens_hsa020100.94066078
67Choline metabolism in cancer_Homo sapiens_hsa052310.93878855
68Graft-versus-host disease_Homo sapiens_hsa053320.91757649
69Asthma_Homo sapiens_hsa053100.89805044
70Serotonergic synapse_Homo sapiens_hsa047260.89266223
71Purine metabolism_Homo sapiens_hsa002300.86278598
72Hedgehog signaling pathway_Homo sapiens_hsa043400.85738122
73Chemical carcinogenesis_Homo sapiens_hsa052040.85274234
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83818209
75Gastric acid secretion_Homo sapiens_hsa049710.82491854
76Salivary secretion_Homo sapiens_hsa049700.81032802
77Circadian rhythm_Homo sapiens_hsa047100.79946113
78Cardiac muscle contraction_Homo sapiens_hsa042600.79891555
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79479263
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79472837
81Notch signaling pathway_Homo sapiens_hsa043300.78778183
82Hematopoietic cell lineage_Homo sapiens_hsa046400.78146181
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.77919874
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77761692
85Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75222380
86Morphine addiction_Homo sapiens_hsa050320.74798779
87Carbon metabolism_Homo sapiens_hsa012000.74793558
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74423935
89Bile secretion_Homo sapiens_hsa049760.69596190
90Systemic lupus erythematosus_Homo sapiens_hsa053220.68563190
91Long-term potentiation_Homo sapiens_hsa047200.68509941
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.68473584
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.65082321
94Calcium signaling pathway_Homo sapiens_hsa040200.64108611
95Collecting duct acid secretion_Homo sapiens_hsa049660.61697403
96Fatty acid degradation_Homo sapiens_hsa000710.60729615
97cAMP signaling pathway_Homo sapiens_hsa040240.59964571
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59953776
99Circadian entrainment_Homo sapiens_hsa047130.59543569
100RNA transport_Homo sapiens_hsa030130.59363584
101Endocytosis_Homo sapiens_hsa041440.58696546
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58175441
103Fatty acid metabolism_Homo sapiens_hsa012120.57437807
104Type II diabetes mellitus_Homo sapiens_hsa049300.56107952
105Phototransduction_Homo sapiens_hsa047440.54621820
106Axon guidance_Homo sapiens_hsa043600.54329348
107Oxytocin signaling pathway_Homo sapiens_hsa049210.52953758
108Inositol phosphate metabolism_Homo sapiens_hsa005620.52430032
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51578000
110Regulation of autophagy_Homo sapiens_hsa041400.51011269
111AMPK signaling pathway_Homo sapiens_hsa041520.50963347
112Ovarian steroidogenesis_Homo sapiens_hsa049130.50321675
113B cell receptor signaling pathway_Homo sapiens_hsa046620.50255346
114Pancreatic secretion_Homo sapiens_hsa049720.49871296
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48783427
116Butanoate metabolism_Homo sapiens_hsa006500.48572041
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.48350368
118Protein digestion and absorption_Homo sapiens_hsa049740.47439238
119Tryptophan metabolism_Homo sapiens_hsa003800.46670317
120Alcoholism_Homo sapiens_hsa050340.45913740
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.45334012
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45332578
123Staphylococcus aureus infection_Homo sapiens_hsa051500.44825724
124Legionellosis_Homo sapiens_hsa051340.44053482
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44007764
126Starch and sucrose metabolism_Homo sapiens_hsa005000.43957168
127GABAergic synapse_Homo sapiens_hsa047270.43412900
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43370150
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.42654868
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42613172
131Histidine metabolism_Homo sapiens_hsa003400.41464691
132Salmonella infection_Homo sapiens_hsa051320.41251123
133Cocaine addiction_Homo sapiens_hsa050300.40456084
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39544218
135Rheumatoid arthritis_Homo sapiens_hsa053230.37924342
136VEGF signaling pathway_Homo sapiens_hsa043700.36884848
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36331356
138Retinol metabolism_Homo sapiens_hsa008300.36056842
139Tight junction_Homo sapiens_hsa045300.35882970
140Synaptic vesicle cycle_Homo sapiens_hsa047210.34700553
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34007722
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.32922525
143Hepatitis C_Homo sapiens_hsa051600.32458695
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32422538
145Basal cell carcinoma_Homo sapiens_hsa052170.32259305
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32137971
147Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30423580
148Sphingolipid metabolism_Homo sapiens_hsa006000.27877365
149Viral carcinogenesis_Homo sapiens_hsa052030.26575799
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25588999
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25347510
152Wnt signaling pathway_Homo sapiens_hsa043100.23521648
153Glutamatergic synapse_Homo sapiens_hsa047240.23175821

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