TTC21B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.28496027
2male meiosis (GO:0007140)7.77690483
3axonemal dynein complex assembly (GO:0070286)6.86292939
4DNA methylation involved in gamete generation (GO:0043046)6.76295661
5synaptonemal complex organization (GO:0070193)6.48173485
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.31531575
7sperm motility (GO:0030317)6.25914807
8synaptonemal complex assembly (GO:0007130)6.20796010
9epithelial cilium movement (GO:0003351)6.11281062
10fusion of sperm to egg plasma membrane (GO:0007342)6.09267419
11motile cilium assembly (GO:0044458)6.03864533
12sperm-egg recognition (GO:0035036)5.71742862
13acrosome assembly (GO:0001675)5.67257557
14cilium movement (GO:0003341)5.62684603
15binding of sperm to zona pellucida (GO:0007339)5.45820792
16spermatid development (GO:0007286)5.21804299
17acrosome reaction (GO:0007340)5.13513437
18multicellular organism reproduction (GO:0032504)5.11959526
19chromosome organization involved in meiosis (GO:0070192)5.06594718
20cell-cell recognition (GO:0009988)5.04373812
21male meiosis I (GO:0007141)4.97448330
22plasma membrane fusion (GO:0045026)4.92363589
23DNA double-strand break processing (GO:0000729)4.63039675
24meiotic nuclear division (GO:0007126)4.45055754
25* intraciliary transport (GO:0042073)4.40899243
26regulation of meiosis I (GO:0060631)4.13714454
27microtubule depolymerization (GO:0007019)4.13008536
28neural tube formation (GO:0001841)4.06924581
29cell wall macromolecule catabolic process (GO:0016998)4.05105956
30cell wall macromolecule metabolic process (GO:0044036)4.05105956
31regulation of cilium movement (GO:0003352)4.03170621
32replicative senescence (GO:0090399)3.89054531
33synapsis (GO:0007129)3.88212757
34somite rostral/caudal axis specification (GO:0032525)3.87959325
35mitotic sister chromatid cohesion (GO:0007064)3.87457434
36gene silencing by RNA (GO:0031047)3.82576579
37reproduction (GO:0000003)3.82257277
38meiosis I (GO:0007127)3.81483318
39single fertilization (GO:0007338)3.77141231
40microtubule anchoring (GO:0034453)3.65484517
41meiotic cell cycle (GO:0051321)3.62973107
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.62321971
43regulation of translation, ncRNA-mediated (GO:0045974)3.62321971
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.62321971
45germ cell development (GO:0007281)3.56962181
46genitalia morphogenesis (GO:0035112)3.56869557
47fertilization (GO:0009566)3.56535590
48left/right pattern formation (GO:0060972)3.54475414
49regulation of centriole replication (GO:0046599)3.53129903
50regulation of centrosome duplication (GO:0010824)3.45348116
51spermatogenesis (GO:0007283)3.41783654
52protein prenylation (GO:0018342)3.41421170
53prenylation (GO:0097354)3.41421170
54male gamete generation (GO:0048232)3.41065641
55gonadal mesoderm development (GO:0007506)3.40747499
56DNA methylation (GO:0006306)3.39640109
57DNA alkylation (GO:0006305)3.39640109
58embryonic foregut morphogenesis (GO:0048617)3.37280174
59replication fork processing (GO:0031297)3.33153823
60cellular process involved in reproduction in multicellular organism (GO:0022412)3.32713492
61pore complex assembly (GO:0046931)3.32440326
62negative regulation of inclusion body assembly (GO:0090084)3.29099148
63* ventricular system development (GO:0021591)3.24549797
64regulation of relaxation of muscle (GO:1901077)3.22884019
65cilium organization (GO:0044782)3.21225266
66meiotic cell cycle process (GO:1903046)3.20724098
67nuclear pore complex assembly (GO:0051292)3.20040462
68negative regulation of DNA repair (GO:0045738)3.19519174
69paraxial mesoderm development (GO:0048339)3.17871083
70cilium assembly (GO:0042384)3.15114403
71limb bud formation (GO:0060174)3.13773322
72gamete generation (GO:0007276)3.13394008
73DNA strand renaturation (GO:0000733)3.13086388
74establishment of protein localization to Golgi (GO:0072600)3.11682606
75inner ear receptor cell development (GO:0060119)3.11150508
76response to X-ray (GO:0010165)3.03829612
77centriole replication (GO:0007099)3.01758937
78seminiferous tubule development (GO:0072520)3.01502707
79histone H2A acetylation (GO:0043968)2.99224291
80sperm capacitation (GO:0048240)2.98408347
81sister chromatid cohesion (GO:0007062)2.96632676
82translesion synthesis (GO:0019985)2.96111102
83positive regulation of male gonad development (GO:2000020)2.92382131
84* protein localization to cilium (GO:0061512)2.92318513
85centriole assembly (GO:0098534)2.90821852
86intra-S DNA damage checkpoint (GO:0031573)2.90047158
87behavioral response to nicotine (GO:0035095)2.89205277
88regulation of centrosome cycle (GO:0046605)2.89121346
89cell recognition (GO:0008037)2.86289127
90microtubule severing (GO:0051013)2.85781134
91protein targeting to Golgi (GO:0000042)2.85473141
92somatic hypermutation of immunoglobulin genes (GO:0016446)2.83503300
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.83503300
94monoubiquitinated protein deubiquitination (GO:0035520)2.82346001
95behavioral response to ethanol (GO:0048149)2.80021601
96meiotic chromosome segregation (GO:0045132)2.79480026
97DNA ligation (GO:0006266)2.78188268
98regulation of histone H3-K9 methylation (GO:0051570)2.77682752
99microtubule organizing center organization (GO:0031023)2.73178497
100interkinetic nuclear migration (GO:0022027)2.72700949
101nuclear pore organization (GO:0006999)2.71995087
102regulation of DNA endoreduplication (GO:0032875)2.71993307
103negative regulation of DNA recombination (GO:0045910)2.71465037
104resolution of meiotic recombination intermediates (GO:0000712)2.71243410
105lactate metabolic process (GO:0006089)2.70453997
106left/right axis specification (GO:0070986)2.70420997
107cellular component assembly involved in morphogenesis (GO:0010927)2.69484544
108microtubule polymerization or depolymerization (GO:0031109)2.68772071
109regulation of male gonad development (GO:2000018)2.67840825
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67318203
111* microtubule-based movement (GO:0007018)2.65890822
112phosphatidylethanolamine metabolic process (GO:0046337)2.65780066
113axoneme assembly (GO:0035082)2.65616503
114nonmotile primary cilium assembly (GO:0035058)2.65472381
115centrosome organization (GO:0051297)2.65038575
116cilium morphogenesis (GO:0060271)2.64538737
117DNA replication checkpoint (GO:0000076)2.63811882
118negative regulation of DNA-dependent DNA replication (GO:2000104)2.63079723
119positive regulation of smoothened signaling pathway (GO:0045880)2.62132794
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.61709049
121reciprocal DNA recombination (GO:0035825)2.61444636
122reciprocal meiotic recombination (GO:0007131)2.61444636
123retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61031221
124cytoplasmic mRNA processing body assembly (GO:0033962)2.60745228
125DNA methylation or demethylation (GO:0044728)2.60594488
126gene silencing (GO:0016458)2.60592041
127olfactory bulb development (GO:0021772)2.59954015
128positive regulation of glycolytic process (GO:0045821)2.59327960
129C4-dicarboxylate transport (GO:0015740)2.58138680
130kidney morphogenesis (GO:0060993)2.57648694
131negative regulation of sodium ion transport (GO:0010766)2.57314272
132regulation of protein polyubiquitination (GO:1902914)2.56977806
133regulation of non-canonical Wnt signaling pathway (GO:2000050)2.56716339
134peptidyl-lysine trimethylation (GO:0018023)2.56714122
135regulation of cell communication by electrical coupling (GO:0010649)2.56201989
136protein polyglutamylation (GO:0018095)2.55570723
137kinetochore organization (GO:0051383)2.54695377
138positive regulation of mRNA processing (GO:0050685)2.52899910
139phosphatidylethanolamine biosynthetic process (GO:0006646)2.51683672
140double-strand break repair via homologous recombination (GO:0000724)2.51399893
141sister chromatid segregation (GO:0000819)2.48625909
142retinal cone cell development (GO:0046549)2.47759495
143regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.47181306
144recombinational repair (GO:0000725)2.47167218
145protein K11-linked deubiquitination (GO:0035871)2.46724037
146regulation of hippo signaling (GO:0035330)2.46663688
147photoreceptor cell maintenance (GO:0045494)2.46234136
148protein K6-linked ubiquitination (GO:0085020)2.46200264
149regulation of establishment of cell polarity (GO:2000114)2.46090077
150keratinocyte development (GO:0003334)2.45653066
151retinal rod cell development (GO:0046548)2.44933143
152calcium ion-dependent exocytosis (GO:0017156)2.44778738
153* smoothened signaling pathway (GO:0007224)2.44690846
154N-terminal protein amino acid acetylation (GO:0006474)2.44593626
155mRNA splice site selection (GO:0006376)2.43948028
156male sex determination (GO:0030238)2.43272943
157head development (GO:0060322)2.43238196
158regulation of protein glycosylation (GO:0060049)2.42481838
159stress granule assembly (GO:0034063)2.42291361
160histone exchange (GO:0043486)2.42187917
161multicellular organismal reproductive process (GO:0048609)2.41452228
162histone H3-K9 methylation (GO:0051567)2.41402616
163poly(A)+ mRNA export from nucleus (GO:0016973)2.40769363
164protein localization to Golgi apparatus (GO:0034067)2.40659602
165positive regulation of meiosis (GO:0045836)2.40533133
166glial cell proliferation (GO:0014009)2.38537610
167regulation of mRNA 3-end processing (GO:0031440)2.37576951
168regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35064402
169maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.34318834
170regulation of acyl-CoA biosynthetic process (GO:0050812)2.33508713
171chromatin remodeling at centromere (GO:0031055)2.33456201
172regulation of growth hormone secretion (GO:0060123)2.33383732
173phosphorelay signal transduction system (GO:0000160)2.33025577
174embryonic axis specification (GO:0000578)2.30922867
175cilium or flagellum-dependent cell motility (GO:0001539)10.6779040

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.71514317
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.65339390
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.35645208
4GBX2_23144817_ChIP-Seq_PC3_Human3.01889127
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85745140
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80587589
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73737377
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.54278900
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.30840132
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26119275
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.24060784
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.21490410
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.19404939
14* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10781766
15* FUS_26573619_Chip-Seq_HEK293_Human2.08648690
16ZNF274_21170338_ChIP-Seq_K562_Hela2.07528909
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99081462
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98640680
19TAF15_26573619_Chip-Seq_HEK293_Human1.95538806
20* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95208477
21RNF2_27304074_Chip-Seq_NSC_Mouse1.87603521
22PCGF2_27294783_Chip-Seq_NPCs_Mouse1.81501849
23* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77237056
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.76500586
25AR_21572438_ChIP-Seq_LNCaP_Human1.76277319
26SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66469479
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.66375820
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66375820
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65731614
30E2F7_22180533_ChIP-Seq_HELA_Human1.62025305
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60204543
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.59887336
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.59714602
34SMAD4_21799915_ChIP-Seq_A2780_Human1.58836162
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58559528
36EWS_26573619_Chip-Seq_HEK293_Human1.58064712
37* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.56334966
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55396274
39P300_19829295_ChIP-Seq_ESCs_Human1.53639838
40ELK1_19687146_ChIP-ChIP_HELA_Human1.53390750
41TCF4_23295773_ChIP-Seq_U87_Human1.51196219
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47236152
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46483650
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44793754
45* P53_22387025_ChIP-Seq_ESCs_Mouse1.43752840
46VDR_22108803_ChIP-Seq_LS180_Human1.43309116
47* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.42987174
48STAT3_23295773_ChIP-Seq_U87_Human1.42857883
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.41604097
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40814575
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39112375
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38579968
53ER_23166858_ChIP-Seq_MCF-7_Human1.37386113
54BCAT_22108803_ChIP-Seq_LS180_Human1.36890923
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35215881
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35171637
57* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.35069786
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34636984
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.34332567
60RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33354673
61TAL1_26923725_Chip-Seq_HPCs_Mouse1.33030954
62* E2F1_18555785_Chip-Seq_ESCs_Mouse1.32218247
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.30175678
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29794460
65* SOX9_26525672_Chip-Seq_HEART_Mouse1.29570671
66* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29337396
67* CMYC_18555785_Chip-Seq_ESCs_Mouse1.27776246
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27154543
69* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26936955
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.26630351
71P300_18555785_Chip-Seq_ESCs_Mouse1.25444755
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.25444415
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.24957200
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.24370404
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.23864819
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23257659
77RUNX2_22187159_ChIP-Seq_PCA_Human1.23243460
78* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22428287
79* STAT3_18555785_Chip-Seq_ESCs_Mouse1.20912391
80KDM2B_26808549_Chip-Seq_REH_Human1.19802749
81* OCT4_18555785_Chip-Seq_ESCs_Mouse1.18965925
82CBP_20019798_ChIP-Seq_JUKART_Human1.18668621
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18668621
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17952620
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17871850
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16856704
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.14800921
88IGF1R_20145208_ChIP-Seq_DFB_Human1.14393556
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10284415
90E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10260012
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09296430
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09094655
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09007035
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08384832
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08168344
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07687106
97DROSHA_22980978_ChIP-Seq_HELA_Human1.05923596
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.04968398
99* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04503462
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04493485
101TP53_16413492_ChIP-PET_HCT116_Human1.04357002
102IRF1_19129219_ChIP-ChIP_H3396_Human1.04154179
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.04034060
104* NMYC_18555785_Chip-Seq_ESCs_Mouse1.03515378
105TCF4_18268006_ChIP-ChIP_LS174T_Human1.02394520
106CRX_20693478_ChIP-Seq_RETINA_Mouse1.02300483
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02105645
108* PU1_27457419_Chip-Seq_LIVER_Mouse1.02042095
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01981492
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.01757995
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01737664
112STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01710946
113CDX2_22108803_ChIP-Seq_LS180_Human1.01652645
114PRDM14_20953172_ChIP-Seq_ESCs_Human1.01256208
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00068459
116TCF4_22108803_ChIP-Seq_LS180_Human0.99992283
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99909051
118* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98790074
119EZH2_27304074_Chip-Seq_ESCs_Mouse0.98244331
120* ZFX_18555785_Chip-Seq_ESCs_Mouse0.97603888
121ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97289061
122TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95316673
123AR_25329375_ChIP-Seq_VCAP_Human0.93855164
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93072537
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93050046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.97237650
2MP0008877_abnormal_DNA_methylation5.85010359
3MP0003698_abnormal_male_reproductive3.16691170
4MP0004043_abnormal_pH_regulation3.04430845
5MP0001929_abnormal_gametogenesis3.00416417
6MP0003787_abnormal_imprinting2.81123993
7MP0002210_abnormal_sex_determination2.63148352
8MP0000569_abnormal_digit_pigmentation2.60696684
9MP0008057_abnormal_DNA_replication2.40492719
10MP0010094_abnormal_chromosome_stability2.16402352
11MP0001145_abnormal_male_reproductive2.14803509
12MP0001188_hyperpigmentation2.10252679
13MP0003195_calcinosis1.97647033
14MP0005623_abnormal_meninges_morphology1.92467628
15MP0000653_abnormal_sex_gland1.90088458
16MP0008058_abnormal_DNA_repair1.83997587
17MP0005171_absent_coat_pigmentation1.82575382
18MP0003121_genomic_imprinting1.77245306
19MP0008007_abnormal_cellular_replicative1.73931353
20MP0006292_abnormal_olfactory_placode1.69488823
21MP0002161_abnormal_fertility/fecundity1.66030487
22MP0005409_darkened_coat_color1.61408574
23MP0000015_abnormal_ear_pigmentation1.60094940
24MP0002090_abnormal_vision1.57822912
25MP0002102_abnormal_ear_morphology1.56470061
26MP0000566_synostosis1.53944438
27MP0004145_abnormal_muscle_electrophysio1.50969418
28MP0002938_white_spotting1.48123505
29MP0001293_anophthalmia1.45648925
30MP0004134_abnormal_chest_morphology1.44475202
31MP0002009_preneoplasia1.42093720
32MP0000631_abnormal_neuroendocrine_gland1.40208706
33MP0005187_abnormal_penis_morphology1.37600852
34MP0003385_abnormal_body_wall1.37383276
35MP0003786_premature_aging1.36456397
36MP0003122_maternal_imprinting1.34551977
37MP0003942_abnormal_urinary_system1.34016344
38MP0000778_abnormal_nervous_system1.32350428
39MP0005646_abnormal_pituitary_gland1.31846523
40MP0008789_abnormal_olfactory_epithelium1.30235930
41MP0005248_abnormal_Harderian_gland1.26418901
42MP0002751_abnormal_autonomic_nervous1.25064251
43MP0002160_abnormal_reproductive_system1.24919448
44MP0005253_abnormal_eye_physiology1.24722675
45MP0009780_abnormal_chondrocyte_physiolo1.22070534
46MP0009703_decreased_birth_body1.20941389
47MP0005503_abnormal_tendon_morphology1.18541964
48MP0003890_abnormal_embryonic-extraembry1.18170682
49MP0005551_abnormal_eye_electrophysiolog1.16831982
50MP0005391_vision/eye_phenotype1.16389501
51MP0000537_abnormal_urethra_morphology1.13872185
52MP0006054_spinal_hemorrhage1.13353891
53MP0003123_paternal_imprinting1.10799264
54MP0002653_abnormal_ependyma_morphology1.10583214
55MP0005174_abnormal_tail_pigmentation1.07956405
56MP0004215_abnormal_myocardial_fiber1.07339168
57MP0002282_abnormal_trachea_morphology1.07241154
58MP0005499_abnormal_olfactory_system1.07229725
59MP0005394_taste/olfaction_phenotype1.07229725
60MP0003937_abnormal_limbs/digits/tail_de1.06505791
61MP0002234_abnormal_pharynx_morphology1.06413498
62MP0000647_abnormal_sebaceous_gland1.06148905
63MP0004808_abnormal_hematopoietic_stem1.05523536
64MP0008995_early_reproductive_senescence1.05149717
65MP0003646_muscle_fatigue1.04566665
66MP0001486_abnormal_startle_reflex1.04054766
67MP0005408_hypopigmentation1.03763214
68MP0002233_abnormal_nose_morphology1.03689356
69MP0005084_abnormal_gallbladder_morpholo1.01338437
70MP0004197_abnormal_fetal_growth/weight/1.00551617
71MP0001286_abnormal_eye_development1.00485492
72MP0001324_abnormal_eye_pigmentation0.99747577
73MP0003880_abnormal_central_pattern0.96535151
74MP0004885_abnormal_endolymph0.95874850
75MP0001299_abnormal_eye_distance/0.95852548
76MP0000427_abnormal_hair_cycle0.95662647
77MP0002092_abnormal_eye_morphology0.95449521
78MP0003950_abnormal_plasma_membrane0.94514927
79MP0009250_abnormal_appendicular_skeleto0.94143355
80MP0003115_abnormal_respiratory_system0.93793458
81MP0001529_abnormal_vocalization0.93559955
82MP0003935_abnormal_craniofacial_develop0.93492560
83MP0006072_abnormal_retinal_apoptosis0.93359642
84MP0000383_abnormal_hair_follicle0.92412589
85MP0003111_abnormal_nucleus_morphology0.91879103
86MP0001177_atelectasis0.91813116
87MP0001986_abnormal_taste_sensitivity0.91685699
88MP0009697_abnormal_copulation0.91652981
89MP0003878_abnormal_ear_physiology0.91081416
90MP0005377_hearing/vestibular/ear_phenot0.91081416
91MP0002638_abnormal_pupillary_reflex0.90380316
92MP0002249_abnormal_larynx_morphology0.90079915
93MP0010030_abnormal_orbit_morphology0.89377687
94MP0003011_delayed_dark_adaptation0.87629857
95MP0000049_abnormal_middle_ear0.87219424
96MP0005645_abnormal_hypothalamus_physiol0.86804378
97* MP0003861_abnormal_nervous_system0.86313574
98MP0000372_irregular_coat_pigmentation0.86069977
99MP0001984_abnormal_olfaction0.85963316
100MP0002116_abnormal_craniofacial_bone0.85066584
101MP0003567_abnormal_fetal_cardiomyocyte0.84674022
102MP0002177_abnormal_outer_ear0.84303104
103MP0004084_abnormal_cardiac_muscle0.84285316
104MP0001346_abnormal_lacrimal_gland0.83891600
105MP0009046_muscle_twitch0.83770450
106MP0000678_abnormal_parathyroid_gland0.82569951
107MP0005389_reproductive_system_phenotype0.82027553
108MP0002095_abnormal_skin_pigmentation0.81897225
109MP0004484_altered_response_of0.81637249
110MP0002697_abnormal_eye_size0.81118475
111MP0008932_abnormal_embryonic_tissue0.78883054
112MP0000432_abnormal_head_morphology0.78240092
113MP0004233_abnormal_muscle_weight0.77488695
114MP0004957_abnormal_blastocyst_morpholog0.77466775
115MP0002229_neurodegeneration0.76463156
116MP0003755_abnormal_palate_morphology0.75283320
117MP0004142_abnormal_muscle_tone0.74599747
118MP0002067_abnormal_sensory_capabilities0.74025422
119MP0002557_abnormal_social/conspecific_i0.73834612
120MP0005423_abnormal_somatic_nervous0.72758327
121MP0010678_abnormal_skin_adnexa0.72512286
122MP0004133_heterotaxia0.71857898
123MP0002272_abnormal_nervous_system0.71218344
124MP0002752_abnormal_somatic_nervous0.70958527
125* MP0002114_abnormal_axial_skeleton0.70467551
126MP0009672_abnormal_birth_weight0.70110961
127MP0005386_behavior/neurological_phenoty0.69981552
128MP0004924_abnormal_behavior0.69981552
129MP0003119_abnormal_digestive_system0.69928481
130MP0003252_abnormal_bile_duct0.68997327
131MP0000955_abnormal_spinal_cord0.68982252
132MP0009745_abnormal_behavioral_response0.68726040
133MP0001485_abnormal_pinna_reflex0.67681832
134* MP0002109_abnormal_limb_morphology0.66941198
135MP0002084_abnormal_developmental_patter0.66927646
136MP0002184_abnormal_innervation0.66889430
137MP0003136_yellow_coat_color0.66883544
138MP0003077_abnormal_cell_cycle0.66614407
139MP0000026_abnormal_inner_ear0.66454719
140MP0005195_abnormal_posterior_eye0.66205099
141MP0002928_abnormal_bile_duct0.65741486
142MP0001119_abnormal_female_reproductive0.65454759
143MP0003938_abnormal_ear_development0.64446714
144MP0003943_abnormal_hepatobiliary_system0.64260309
145* MP0002152_abnormal_brain_morphology0.64207134

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.08441532
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.49875090
3Absent/shortened dynein arms (HP:0200106)7.49875090
4Abnormal respiratory motile cilium physiology (HP:0012261)5.74165400
5Abnormal respiratory motile cilium morphology (HP:0005938)5.32911397
6Abnormal respiratory epithelium morphology (HP:0012253)5.32911397
7Abnormal ciliary motility (HP:0012262)5.00598353
8Rhinitis (HP:0012384)4.54872665
9Tubulointerstitial nephritis (HP:0001970)4.41844599
10* Nephronophthisis (HP:0000090)4.08469064
11Chronic bronchitis (HP:0004469)3.69396045
12* Abnormality of the renal medulla (HP:0100957)3.40463034
13Fibular hypoplasia (HP:0003038)3.33431221
14Intestinal atresia (HP:0011100)3.29437708
15Papillary thyroid carcinoma (HP:0002895)3.22843664
16Hyperventilation (HP:0002883)3.04298287
17Molar tooth sign on MRI (HP:0002419)3.01526584
18Abnormality of midbrain morphology (HP:0002418)3.01526584
19Bronchiectasis (HP:0002110)3.01488231
20Chronic hepatic failure (HP:0100626)3.00219702
21Infertility (HP:0000789)2.99432111
22Gonadotropin excess (HP:0000837)2.87122921
23* Postaxial foot polydactyly (HP:0001830)2.86300948
24Pancreatic islet-cell hyperplasia (HP:0004510)2.83157207
25Abnormality of the lower motor neuron (HP:0002366)2.81406149
26Hepatoblastoma (HP:0002884)2.72816160
27Renal cortical cysts (HP:0000803)2.61511726
28Medial flaring of the eyebrow (HP:0010747)2.59358078
29Anterior segment dysgenesis (HP:0007700)2.54075633
30Tubulointerstitial abnormality (HP:0001969)2.51157468
31Aplasia/Hypoplasia of the fibula (HP:0006492)2.49662200
32Aqueductal stenosis (HP:0002410)2.48286047
33Facial cleft (HP:0002006)2.45995962
34Absent frontal sinuses (HP:0002688)2.37915160
35Colon cancer (HP:0003003)2.36003448
36Selective tooth agenesis (HP:0001592)2.35954175
37Abnormality of dentin (HP:0010299)2.34937684
38Abnormal spermatogenesis (HP:0008669)2.34934121
39Median cleft lip (HP:0000161)2.30340875
40Drooling (HP:0002307)2.30040760
41Poor coordination (HP:0002370)2.28485396
42Nasal polyposis (HP:0100582)2.27251781
43Hyperinsulinemic hypoglycemia (HP:0000825)2.27164232
44Chromsome breakage (HP:0040012)2.26426439
45Bronchitis (HP:0012387)2.25052695
46Renal dysplasia (HP:0000110)2.24869824
47Abnormality of the labia minora (HP:0012880)2.24564789
4811 pairs of ribs (HP:0000878)2.24011050
49Thyroid carcinoma (HP:0002890)2.22853798
50Pancreatic fibrosis (HP:0100732)2.21176341
51Astrocytoma (HP:0009592)2.20430997
52Abnormality of the astrocytes (HP:0100707)2.20430997
53Amyotrophic lateral sclerosis (HP:0007354)2.19875651
54Congenital hepatic fibrosis (HP:0002612)2.19348070
55Ectopic kidney (HP:0000086)2.18905069
56Fair hair (HP:0002286)2.15680732
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.14169675
58Glioma (HP:0009733)2.14096557
59Febrile seizures (HP:0002373)2.11358818
60Abnormality of the renal cortex (HP:0011035)2.09017081
61Azoospermia (HP:0000027)2.09002045
62Nephroblastoma (Wilms tumor) (HP:0002667)2.07993499
63True hermaphroditism (HP:0010459)2.06302423
64Abnormality of the parathyroid morphology (HP:0011766)2.05943053
65Sloping forehead (HP:0000340)2.04620050
66Supernumerary spleens (HP:0009799)2.04532322
67Cupped ear (HP:0000378)2.04268545
68Protruding tongue (HP:0010808)2.02153965
69Rhabdomyosarcoma (HP:0002859)2.01762703
70Excessive salivation (HP:0003781)2.01237434
71Preaxial hand polydactyly (HP:0001177)2.01156164
72Hypoglycemic seizures (HP:0002173)2.00967409
73Microglossia (HP:0000171)2.00829548
74Abnormality of the ileum (HP:0001549)2.00094052
75* Postaxial hand polydactyly (HP:0001162)2.00049250
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.99163353
77Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98433985
78Embryonal renal neoplasm (HP:0011794)1.97547897
79Abnormality of molar morphology (HP:0011070)1.97248121
80Abnormality of molar (HP:0011077)1.97248121
81Tubular atrophy (HP:0000092)1.97088813
82Meckel diverticulum (HP:0002245)1.96760379
83Oligodactyly (hands) (HP:0001180)1.94753226
84Cystic liver disease (HP:0006706)1.94722118
85Renovascular hypertension (HP:0100817)1.94518304
86Atonic seizures (HP:0010819)1.94382340
87Abnormality of the phalanges of the hallux (HP:0010057)1.94377075
88Hypothermia (HP:0002045)1.93614467
89Neoplasm of the adrenal cortex (HP:0100641)1.93507143
90Hypoglycemic coma (HP:0001325)1.91977139
91Abnormality of permanent molar morphology (HP:0011071)1.91218481
92Abnormality of the dental root (HP:0006486)1.91218481
93Taurodontia (HP:0000679)1.91218481
94Bell-shaped thorax (HP:0001591)1.90624028
95Broad-based gait (HP:0002136)1.89775930
96Abnormality of chromosome stability (HP:0003220)1.88200964
97Absent speech (HP:0001344)1.87070716
98Absent eyebrow (HP:0002223)1.85944822
99Ependymoma (HP:0002888)1.85805942
100Medulloblastoma (HP:0002885)1.84607948
101* Stage 5 chronic kidney disease (HP:0003774)1.82317809
102Type II lissencephaly (HP:0007260)1.81857126
103Congenital primary aphakia (HP:0007707)1.81573303
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.80523806
105Gait imbalance (HP:0002141)1.80129596
106Labial hypoplasia (HP:0000066)1.78239186
107Midline defect of the nose (HP:0004122)1.78233649
108Abnormality of endocrine pancreas physiology (HP:0012093)1.78109579
109Abnormality of the pancreatic islet cells (HP:0006476)1.78109579
110Submucous cleft hard palate (HP:0000176)1.78107994
111Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78080381
112Abnormal hair whorl (HP:0010721)1.77809428
113Anal stenosis (HP:0002025)1.77047616
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.76508928
115Abnormality of the nasal septum (HP:0000419)1.75322605
116Short tibia (HP:0005736)1.74427455
117Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.72212430
118Abnormality of the dental pulp (HP:0006479)1.72211567
119Hypoplastic iliac wings (HP:0002866)1.70116047
120Retinal dysplasia (HP:0007973)1.69070111
121Dandy-Walker malformation (HP:0001305)1.69034149
122Abnormality of macular pigmentation (HP:0008002)1.67487034
123Recurrent otitis media (HP:0000403)1.66761230
124Neoplasm of the oral cavity (HP:0100649)1.65523298
125Nephrogenic diabetes insipidus (HP:0009806)1.65166606
126Prominent nasal bridge (HP:0000426)1.63863887
127Cutaneous finger syndactyly (HP:0010554)1.63642962
128Bile duct proliferation (HP:0001408)1.63615771
129Abnormal biliary tract physiology (HP:0012439)1.63615771
130Thyroiditis (HP:0100646)1.63228121
131Biliary tract neoplasm (HP:0100574)1.63078496
132Growth hormone deficiency (HP:0000824)1.62419179
133Genital tract atresia (HP:0001827)1.61996139
134Hypoplastic female external genitalia (HP:0012815)1.61063613
135Short foot (HP:0001773)1.60307679
136* Short ribs (HP:0000773)1.60268356
137Clitoromegaly (HP:0000057)1.59840702
138Decreased lacrimation (HP:0000633)1.59833813
139Short 4th metacarpal (HP:0010044)1.59730506
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.59730506
141Optic nerve hypoplasia (HP:0000609)1.59298721
142Abnormality of the ischium (HP:0003174)1.58855846
143Aplasia/Hypoplasia of the lens (HP:0008063)1.58024924
144Vaginal atresia (HP:0000148)1.56600216
145Occipital encephalocele (HP:0002085)1.55734324
146Gaze-evoked nystagmus (HP:0000640)1.54321695
147Impulsivity (HP:0100710)1.51648778
148Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.51635144
149Pancreatic cysts (HP:0001737)1.50153295
150Bifid tongue (HP:0010297)1.49820936
151Cone-rod dystrophy (HP:0000548)1.49687685
152Abnormality of the nasal mucosa (HP:0000433)1.48829526
153Pachygyria (HP:0001302)1.48565669
154Oculomotor apraxia (HP:0000657)1.48137112
155Cutaneous syndactyly (HP:0012725)1.48136848
156Progressive sensorineural hearing impairment (HP:0000408)1.47992732
157Astigmatism (HP:0000483)1.47698621
158Volvulus (HP:0002580)1.46846459
159Dental crowding (HP:0000678)1.45727042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.28790594
2PDK36.28790594
3PDK23.29692664
4MAP4K23.18655209
5AKT32.82963223
6CASK2.51608844
7BRD42.42728055
8BRSK22.32276116
9TRIM282.01732643
10ACVR1B1.99045714
11CDC71.97859411
12CCNB11.97206708
13WNK41.85470947
14PASK1.81183444
15NUAK11.80608192
16NTRK31.78209661
17IRAK21.77255155
18PTK2B1.73762892
19IRAK11.70556128
20STK391.70472195
21ATR1.61347288
22CDK121.53772999
23NEK21.48010253
24ICK1.45260451
25MAP3K41.44787575
26TTK1.43631532
27PRKD31.41553527
28BMPR1B1.38167440
29PNCK1.37717204
30OBSCN1.36650943
31FRK1.33661374
32STK31.33276197
33YES11.30167085
34TESK11.30150623
35WNK11.25395835
36MKNK11.24810175
37NLK1.24775368
38MKNK21.24556570
39LATS11.24392557
40CAMK1G1.23347116
41SGK21.19209638
42FGFR21.16234240
43PINK11.13849076
44MAP2K71.13015634
45ERBB31.11188710
46SRPK11.06694670
47CDK31.06177818
48ZAK1.04498795
49CDK91.02408424
50INSRR1.00228897
51PDGFRA0.98643765
52SIK30.98005120
53CDK80.95443259
54PIK3CG0.94043315
55CAMK1D0.93370734
56NEK10.92328528
57STK38L0.92287934
58CSNK1G10.92128890
59MAPK130.90445192
60PLK40.87725627
61ATM0.87206201
62CHEK10.86981431
63PDGFRB0.85339658
64CHEK20.84268241
65DYRK1B0.79839742
66EIF2AK20.79358085
67TSSK60.78702025
68SGK30.75715427
69FGFR30.74813734
70GRK10.74756421
71CDK70.74581049
72PAK30.73911916
73PBK0.72669036
74CSNK1A1L0.72557784
75PLK20.71427366
76LMTK20.71418053
77PLK30.69902174
78EEF2K0.69718575
79EIF2AK10.68591712
80VRK10.65673043
81SIK20.64309318
82PLK10.63695071
83CSNK1G20.63600246
84SGK2230.62675805
85SGK4940.62675805
86EPHA40.62045919
87EIF2AK30.61268376
88TNK20.57106241
89DYRK30.56782951
90OXSR10.55901620
91WNK30.55424430
92CSNK1G30.55333217
93EPHA30.54292611
94FGFR10.54114006
95MAP3K20.54080225
96NTRK20.54017306
97RPS6KB10.52540196
98TRPM70.52048573
99MAPK150.50247538
100PRKCE0.48111307
101FER0.47911914
102TNIK0.47154317
103RPS6KA40.47110422
104PRKAA20.46391306
105BRSK10.46174502
106PRKDC0.45069300
107CDK10.44814275
108PTK60.44516527
109PIK3CA0.44085282
110CAMK40.43043938
111STK380.41537074
112MELK0.41021345
113MARK10.39788195
114PRKG10.39776914
115WEE10.39582929
116DYRK1A0.39160102
117FLT30.38275196
118CAMKK20.37861457
119KSR10.37269504
120BCR0.36585093
121CSNK1E0.34444939
122CSNK1D0.34395440
123PRKAA10.34385250
124STK160.34180843
125MST40.32598025
126MAP2K40.32330984
127TGFBR10.31508987
128MAPK100.31246755
129ERBB40.30670634
130MAPK80.30452475
131GSK3B0.29848068
132MTOR0.29687799
133TAF10.26914361
134MUSK0.26496677
135PRKCG0.26441514
136SGK10.25401939
137NEK60.24949016
138AKT10.23856282
139PAK40.23756625

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.44477271
2Non-homologous end-joining_Homo sapiens_hsa034502.88137177
3Propanoate metabolism_Homo sapiens_hsa006402.76824459
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51582585
5Homologous recombination_Homo sapiens_hsa034402.45087189
6Basal transcription factors_Homo sapiens_hsa030222.29505580
7Mismatch repair_Homo sapiens_hsa034302.21884856
8Circadian rhythm_Homo sapiens_hsa047102.10525244
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03918841
10Lysine degradation_Homo sapiens_hsa003102.01035090
11Nicotine addiction_Homo sapiens_hsa050331.99340361
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91043728
13Phototransduction_Homo sapiens_hsa047441.86202055
14Butanoate metabolism_Homo sapiens_hsa006501.79459729
15Cell cycle_Homo sapiens_hsa041101.78732814
16Fatty acid elongation_Homo sapiens_hsa000621.78548042
17mRNA surveillance pathway_Homo sapiens_hsa030151.76846380
18Amphetamine addiction_Homo sapiens_hsa050311.75015834
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.74335389
20Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65019376
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.59656232
22Dorso-ventral axis formation_Homo sapiens_hsa043201.59111973
23Taste transduction_Homo sapiens_hsa047421.52843268
24Glucagon signaling pathway_Homo sapiens_hsa049221.52606708
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50820713
26Oocyte meiosis_Homo sapiens_hsa041141.49902909
27Nucleotide excision repair_Homo sapiens_hsa034201.49134954
28Nitrogen metabolism_Homo sapiens_hsa009101.48324236
29RNA degradation_Homo sapiens_hsa030181.48308351
30Protein export_Homo sapiens_hsa030601.45898989
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43155717
32Basal cell carcinoma_Homo sapiens_hsa052171.29741952
33RNA transport_Homo sapiens_hsa030131.29564979
34Wnt signaling pathway_Homo sapiens_hsa043101.29328971
35Long-term potentiation_Homo sapiens_hsa047201.27061074
36Fatty acid metabolism_Homo sapiens_hsa012121.25086216
37Steroid biosynthesis_Homo sapiens_hsa001001.23703566
38Circadian entrainment_Homo sapiens_hsa047131.23173429
39Fatty acid biosynthesis_Homo sapiens_hsa000611.22561912
40Axon guidance_Homo sapiens_hsa043601.18764880
41ABC transporters_Homo sapiens_hsa020101.18674230
42Spliceosome_Homo sapiens_hsa030401.15915617
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15470273
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14856087
45Glutamatergic synapse_Homo sapiens_hsa047241.14790782
46DNA replication_Homo sapiens_hsa030301.14611544
47Renin secretion_Homo sapiens_hsa049241.10819806
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.07938440
49Hedgehog signaling pathway_Homo sapiens_hsa043401.05628361
50Regulation of autophagy_Homo sapiens_hsa041401.04687670
51Alcoholism_Homo sapiens_hsa050341.02487716
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01488664
53Olfactory transduction_Homo sapiens_hsa047401.00866759
54Selenocompound metabolism_Homo sapiens_hsa004501.00755132
55Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00676890
56Systemic lupus erythematosus_Homo sapiens_hsa053220.97478756
57Peroxisome_Homo sapiens_hsa041460.96286292
58Fatty acid degradation_Homo sapiens_hsa000710.95532831
59Insulin secretion_Homo sapiens_hsa049110.95381656
60Chemical carcinogenesis_Homo sapiens_hsa052040.95294324
61Morphine addiction_Homo sapiens_hsa050320.95150137
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93647515
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.93325535
64Dopaminergic synapse_Homo sapiens_hsa047280.92944585
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91713475
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90499389
67Cocaine addiction_Homo sapiens_hsa050300.87620613
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.87592012
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.87061360
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85684325
71p53 signaling pathway_Homo sapiens_hsa041150.84400577
72Base excision repair_Homo sapiens_hsa034100.82693555
73Adherens junction_Homo sapiens_hsa045200.82655380
74Calcium signaling pathway_Homo sapiens_hsa040200.81582910
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81470865
76Hippo signaling pathway_Homo sapiens_hsa043900.80955203
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80920277
78HTLV-I infection_Homo sapiens_hsa051660.80479753
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80287341
80Pyruvate metabolism_Homo sapiens_hsa006200.79577487
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79195232
82Melanoma_Homo sapiens_hsa052180.77236276
83FoxO signaling pathway_Homo sapiens_hsa040680.75670631
84Type II diabetes mellitus_Homo sapiens_hsa049300.75657546
85cAMP signaling pathway_Homo sapiens_hsa040240.75437463
86One carbon pool by folate_Homo sapiens_hsa006700.74815004
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74747260
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74113077
89Tryptophan metabolism_Homo sapiens_hsa003800.73624916
90Melanogenesis_Homo sapiens_hsa049160.73495268
91Estrogen signaling pathway_Homo sapiens_hsa049150.72953463
92Viral carcinogenesis_Homo sapiens_hsa052030.71653179
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71372092
94Complement and coagulation cascades_Homo sapiens_hsa046100.70141342
95Serotonergic synapse_Homo sapiens_hsa047260.68976722
96Prostate cancer_Homo sapiens_hsa052150.68005288
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67730712
98Caffeine metabolism_Homo sapiens_hsa002320.66544292
99ECM-receptor interaction_Homo sapiens_hsa045120.66445036
100Purine metabolism_Homo sapiens_hsa002300.66211333
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64954564
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64129595
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63120463
104GABAergic synapse_Homo sapiens_hsa047270.63046760
105Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62835144
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62335880
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.61532369
108N-Glycan biosynthesis_Homo sapiens_hsa005100.61150834
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60992905
110Small cell lung cancer_Homo sapiens_hsa052220.60695593
111Linoleic acid metabolism_Homo sapiens_hsa005910.60303922
112Oxytocin signaling pathway_Homo sapiens_hsa049210.59759238
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59635163
114TGF-beta signaling pathway_Homo sapiens_hsa043500.59343538
115Inositol phosphate metabolism_Homo sapiens_hsa005620.58812907
116Retinol metabolism_Homo sapiens_hsa008300.57968958
117ErbB signaling pathway_Homo sapiens_hsa040120.57212315
118MicroRNAs in cancer_Homo sapiens_hsa052060.57211189
119Cholinergic synapse_Homo sapiens_hsa047250.56640959
120mTOR signaling pathway_Homo sapiens_hsa041500.56539919
121Ras signaling pathway_Homo sapiens_hsa040140.56424073
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56114663
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55780385
124Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55522214
125Colorectal cancer_Homo sapiens_hsa052100.54811752
126Ether lipid metabolism_Homo sapiens_hsa005650.54618233
127Long-term depression_Homo sapiens_hsa047300.53733294
128beta-Alanine metabolism_Homo sapiens_hsa004100.53558278
129Glioma_Homo sapiens_hsa052140.53355295
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51818341
131Endometrial cancer_Homo sapiens_hsa052130.51753975
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.51673825
133Huntingtons disease_Homo sapiens_hsa050160.51546762
134MAPK signaling pathway_Homo sapiens_hsa040100.48080174
135Focal adhesion_Homo sapiens_hsa045100.47500903
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47463372
137Pathways in cancer_Homo sapiens_hsa052000.47124437
138Histidine metabolism_Homo sapiens_hsa003400.47091976
139Salivary secretion_Homo sapiens_hsa049700.46582945
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.45545694
141Choline metabolism in cancer_Homo sapiens_hsa052310.44951445
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44594506
143Ovarian steroidogenesis_Homo sapiens_hsa049130.44148120
144Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42710646
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42693533
146Pyrimidine metabolism_Homo sapiens_hsa002400.42470418
147AMPK signaling pathway_Homo sapiens_hsa041520.42095512
148Glycerophospholipid metabolism_Homo sapiens_hsa005640.40244273
149Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39411049
150Glycerolipid metabolism_Homo sapiens_hsa005610.39295537

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