TTC22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.69404061
2intestinal cholesterol absorption (GO:0030299)7.71277422
3angiotensin maturation (GO:0002003)6.60683897
43-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)6.22802234
5purine ribonucleoside bisphosphate metabolic process (GO:0034035)6.22802234
6bundle of His cell to Purkinje myocyte communication (GO:0086069)5.65111408
7sulfate transmembrane transport (GO:1902358)4.90515833
8peptide hormone processing (GO:0016486)4.84474818
9virion attachment to host cell (GO:0019062)4.77438016
10adhesion of symbiont to host cell (GO:0044650)4.77438016
11vitamin A metabolic process (GO:0006776)4.73740328
12maintenance of gastrointestinal epithelium (GO:0030277)4.73653972
13regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.69111651
14positive regulation of respiratory burst (GO:0060267)4.55152496
15COPI coating of Golgi vesicle (GO:0048205)4.52947683
16Golgi transport vesicle coating (GO:0048200)4.52947683
17desmosome organization (GO:0002934)4.51271328
18UDP-N-acetylglucosamine metabolic process (GO:0006047)4.50960285
19digestive system process (GO:0022600)4.50146079
20actin filament depolymerization (GO:0030042)4.41942649
21negative regulation of keratinocyte proliferation (GO:0010839)4.31979442
22flavonoid metabolic process (GO:0009812)4.29414016
23hemidesmosome assembly (GO:0031581)4.28763937
24response to hepatocyte growth factor (GO:0035728)4.21155280
25cellular response to hepatocyte growth factor stimulus (GO:0035729)4.21155280
26intestinal epithelial cell development (GO:0060576)3.98525489
27digestion (GO:0007586)3.90723498
28sulfate transport (GO:0008272)3.88918212
29cytidine deamination (GO:0009972)3.85355337
30cytidine metabolic process (GO:0046087)3.85355337
31cytidine catabolic process (GO:0006216)3.85355337
32cellular ketone body metabolic process (GO:0046950)3.81802303
33adhesion of symbiont to host (GO:0044406)3.80178300
34endocrine pancreas development (GO:0031018)3.78115445
35L-fucose catabolic process (GO:0042355)3.77114973
36fucose catabolic process (GO:0019317)3.77114973
37L-fucose metabolic process (GO:0042354)3.77114973
38regulation of autophagic vacuole assembly (GO:2000785)3.74764001
39epithelial structure maintenance (GO:0010669)3.70375905
40sulfur compound transport (GO:0072348)3.58748593
41negative regulation of protein oligomerization (GO:0032460)3.58528658
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58120593
43drug catabolic process (GO:0042737)3.53898004
44bile acid and bile salt transport (GO:0015721)3.53796968
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.49583501
46regulation of viral release from host cell (GO:1902186)3.46618844
47negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.45412106
48regulation of water loss via skin (GO:0033561)3.44798869
49COPII vesicle coating (GO:0048208)3.43756073
50O-glycan processing (GO:0016266)3.43211222
51glandular epithelial cell differentiation (GO:0002067)3.41720453
52phosphatidylserine acyl-chain remodeling (GO:0036150)3.37261806
53protein retention in ER lumen (GO:0006621)3.37258935
54ketone body metabolic process (GO:1902224)3.36298108
55thyroid hormone metabolic process (GO:0042403)3.35654015
56regulation of cholesterol homeostasis (GO:2000188)3.33992543
57negative regulation of digestive system process (GO:0060457)3.33513175
58regulation of type B pancreatic cell apoptotic process (GO:2000674)3.32218133
59epoxygenase P450 pathway (GO:0019373)3.25198100
60axoneme assembly (GO:0035082)3.24567574
61epithelial cell-cell adhesion (GO:0090136)3.22896906
62transepithelial transport (GO:0070633)3.22599542
63sulfation (GO:0051923)3.21204560
64regulation of guanylate cyclase activity (GO:0031282)3.21073342
65regulation of Golgi to plasma membrane protein transport (GO:0042996)3.20321952
66positive regulation of T cell differentiation in thymus (GO:0033089)3.19828323
67fucosylation (GO:0036065)3.17051367
68regulation of protein glycosylation (GO:0060049)3.16581108
69antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16146600
70pyrimidine ribonucleoside catabolic process (GO:0046133)3.15690826
71uronic acid metabolic process (GO:0006063)3.11919177
72glucuronate metabolic process (GO:0019585)3.11919177
73regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.10093785
74establishment of skin barrier (GO:0061436)3.09430012
75nucleotide transmembrane transport (GO:1901679)3.09272633
76positive regulation of epidermal cell differentiation (GO:0045606)3.09100945
77hormone catabolic process (GO:0042447)3.08217523
78calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.07958692
79peptide catabolic process (GO:0043171)3.07089540
80positive regulation of glycoprotein biosynthetic process (GO:0010560)3.05594846
81lipoprotein metabolic process (GO:0042157)3.05056134
82exogenous drug catabolic process (GO:0042738)3.05038138
83phospholipid efflux (GO:0033700)3.02715113
84drug metabolic process (GO:0017144)3.02399613
85nucleotide-sugar biosynthetic process (GO:0009226)3.01408444
86regulation of vitamin metabolic process (GO:0030656)3.01195834
87membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.01188920
88negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.01047609
89GDP-mannose metabolic process (GO:0019673)3.00682213
90purine nucleoside bisphosphate metabolic process (GO:0034032)3.00575275
91ribonucleoside bisphosphate metabolic process (GO:0033875)3.00575275
92nucleoside bisphosphate metabolic process (GO:0033865)3.00575275
93cellular glucuronidation (GO:0052695)3.00571608
94keratinocyte development (GO:0003334)2.98769830
95auditory receptor cell differentiation (GO:0042491)2.96838020
96intermediate filament organization (GO:0045109)2.94156183
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93301317
98water-soluble vitamin biosynthetic process (GO:0042364)2.93136191
99transcytosis (GO:0045056)2.91776636
100regulation of bile acid biosynthetic process (GO:0070857)2.91493995
101regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.91415942
102endocrine process (GO:0050886)2.91415942
103regulation of systemic arterial blood pressure by hormone (GO:0001990)2.91415942
104bicarbonate transport (GO:0015701)2.91302896
105regulation of respiratory burst (GO:0060263)2.90592893
106phenylpropanoid metabolic process (GO:0009698)2.90063982
107glucose 6-phosphate metabolic process (GO:0051156)2.88577498
108retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87047962
109modified amino acid transport (GO:0072337)2.86991464
110antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86065204
111regulation of vacuole organization (GO:0044088)2.84118758
112cilium or flagellum-dependent cell motility (GO:0001539)2.83987712
113phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.83960522
114renal absorption (GO:0070293)2.81465160
115ventricular cardiac muscle cell action potential (GO:0086005)2.80947535
116negative regulation of protein tyrosine kinase activity (GO:0061099)2.79752732
117positive regulation of guanylate cyclase activity (GO:0031284)2.76153609
118phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.76049940
119diol metabolic process (GO:0034311)2.75590588
120antigen processing and presentation of endogenous antigen (GO:0019883)2.75348538
121positive regulation of epidermis development (GO:0045684)2.74923269
122cell communication involved in cardiac conduction (GO:0086065)2.73415993
123positive regulation of glycolytic process (GO:0045821)2.73195441
124regulation of cellular extravasation (GO:0002691)2.73041997
125negative regulation of T cell differentiation in thymus (GO:0033085)2.72505722
126multicellular organismal water homeostasis (GO:0050891)2.70845162
127alkaloid metabolic process (GO:0009820)2.70711177
128membrane repolarization during action potential (GO:0086011)2.70086601
129drug transmembrane transport (GO:0006855)2.69086356
130kidney morphogenesis (GO:0060993)2.68000803
131water homeostasis (GO:0030104)2.67879536
132sphingomyelin metabolic process (GO:0006684)2.64763309
133keratinization (GO:0031424)2.64742614
134positive regulation of fatty acid biosynthetic process (GO:0045723)2.64668564
135cellular response to vitamin D (GO:0071305)2.62811463
136nitric oxide mediated signal transduction (GO:0007263)2.61156034
137regulation of triglyceride catabolic process (GO:0010896)2.60849785
138phosphatidylcholine acyl-chain remodeling (GO:0036151)2.59854545
139regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.59016776
140columnar/cuboidal epithelial cell development (GO:0002066)2.58329304
141vitamin biosynthetic process (GO:0009110)2.57925164
142regulation of keratinocyte proliferation (GO:0010837)2.57697707
143diacylglycerol metabolic process (GO:0046339)2.57662305
144phosphatidylcholine metabolic process (GO:0046470)2.56156159
145ethanolamine-containing compound metabolic process (GO:0042439)2.53833892
146adaptation of signaling pathway (GO:0023058)2.53351909
147phosphatidylcholine biosynthetic process (GO:0006656)2.50484197
148insulin secretion (GO:0030073)2.48797503
149regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.47085519
150positive regulation of glycoprotein metabolic process (GO:1903020)2.44316076
151cobalamin metabolic process (GO:0009235)2.38908309
152L-ascorbic acid metabolic process (GO:0019852)2.38089854
153regulation of cGMP biosynthetic process (GO:0030826)2.36904738
154peptide transport (GO:0015833)2.36884932
155arginine metabolic process (GO:0006525)2.35780386
156regulation of systemic arterial blood pressure (GO:0003073)2.35422079
157organic cation transport (GO:0015695)2.35011642
158negative regulation of acute inflammatory response (GO:0002674)2.34728674
159retinol metabolic process (GO:0042572)2.33629851
160cellular response to zinc ion (GO:0071294)2.32922752
161macroautophagy (GO:0016236)2.31465141
162interferon-gamma secretion (GO:0072643)2.29958207
163regulation of hexokinase activity (GO:1903299)2.29060365
164regulation of glucokinase activity (GO:0033131)2.29060365

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.38729804
2CDX2_20551321_ChIP-Seq_CACO-2_Human3.86389039
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.41813848
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.88877541
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.76810749
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62195066
7SOX2_20726797_ChIP-Seq_SW620_Human2.62162755
8GATA4_25053715_ChIP-Seq_YYC3_Human2.57395019
9GATA6_25053715_ChIP-Seq_YYC3_Human2.36626467
10VDR_22108803_ChIP-Seq_LS180_Human2.32396274
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.27242510
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17596397
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.13998618
14ZNF274_21170338_ChIP-Seq_K562_Hela2.07232331
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.00045229
16EGR1_23403033_ChIP-Seq_LIVER_Mouse1.91902360
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.90116350
18PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82320207
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82045281
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73023316
21SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70713512
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.69801794
23FOXO3_23340844_ChIP-Seq_DLD1_Human1.69322428
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.67812459
25KLF5_25053715_ChIP-Seq_YYC3_Human1.66328807
26RACK7_27058665_Chip-Seq_MCF-7_Human1.64587689
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59662601
28ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.54327250
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.53241537
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52191628
31FOXA1_25329375_ChIP-Seq_VCAP_Human1.52191628
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51915594
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50858875
34* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47377215
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.46636886
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.45686294
37ESR1_20079471_ChIP-ChIP_T-47D_Human1.45584300
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39481494
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38027218
40* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37892438
41TCF4_18268006_ChIP-ChIP_LS174T_Human1.36028360
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35888222
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34841699
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34742403
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.33815979
46GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.30836298
47FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30495234
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30454401
49NCOR_22424771_ChIP-Seq_293T_Human1.29824781
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29670385
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.27919016
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.27697017
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27662749
54SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26967616
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26698719
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26407722
57ER_23166858_ChIP-Seq_MCF-7_Human1.25138887
58* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24795033
59TCF4_22108803_ChIP-Seq_LS180_Human1.24670524
60GATA3_21878914_ChIP-Seq_MCF-7_Human1.24641220
61AR_20517297_ChIP-Seq_VCAP_Human1.24593748
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24231030
63AR_25329375_ChIP-Seq_VCAP_Human1.23457501
64ATF3_27146783_Chip-Seq_COLON_Human1.21073208
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20475212
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.20290265
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19399891
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19202456
69TP63_22573176_ChIP-Seq_HFKS_Human1.18486152
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18474778
71MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18239795
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17180249
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16269277
74FOXA1_25552417_ChIP-Seq_VCAP_Human1.16071865
75CLOCK_20551151_ChIP-Seq_293T_Human1.14938095
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14326082
77GATA3_24758297_ChIP-Seq_MCF-7_Human1.13491498
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12256306
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12184583
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.11570069
81GBX2_23144817_ChIP-Seq_PC3_Human1.11557126
82* NANOG_20526341_ChIP-Seq_ESCs_Human1.11059301
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09559375
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08001667
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07756855
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07059730
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06878193
88TAF2_19829295_ChIP-Seq_ESCs_Human1.06864272
89* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06482451
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.06365288
91MYC_19829295_ChIP-Seq_ESCs_Human1.05694936
92SMRT_27268052_Chip-Seq_Bcells_Human1.05505883
93FOXH1_21741376_ChIP-Seq_ESCs_Human1.04760233
94* RBPJ_21746931_ChIP-Seq_IB4_Human1.04658007
95ARNT_22903824_ChIP-Seq_MCF-7_Human1.04402573
96SMAD4_21799915_ChIP-Seq_A2780_Human1.04289893
97* HNFA_21074721_ChIP-Seq_CACO-2_Human1.03913551
98ETV1_20927104_ChIP-Seq_GIST48_Human1.03806031
99IRF8_21731497_ChIP-ChIP_J774_Mouse1.03713150
100* STAT3_23295773_ChIP-Seq_U87_Human1.02925882
101HOXB7_26014856_ChIP-Seq_BT474_Human1.02719230
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02670946
103NANOG_19829295_ChIP-Seq_ESCs_Human1.02497090
104SOX2_19829295_ChIP-Seq_ESCs_Human1.02497090
105GATA2_19941826_ChIP-Seq_K562_Human1.01898957
106DROSHA_22980978_ChIP-Seq_HELA_Human1.01298727
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01145012
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00441738
109CREB1_26743006_Chip-Seq_LNCaP_Human1.00351796
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00001999
111* LXR_22292898_ChIP-Seq_THP-1_Human0.99429355
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99185995
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98887248
114CBP_20019798_ChIP-Seq_JUKART_Human0.98887248
115ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98564743
116CEBPB_22108803_ChIP-Seq_LS180_Human0.98495937
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98397556
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98135931
119* PHF8_20622853_ChIP-Seq_HELA_Human0.97721739
120TCF4_23295773_ChIP-Seq_U87_Human0.97517822
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97365417
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97173099
123GATA3_26560356_Chip-Seq_TH2_Human0.96972904
124FOXA2_19822575_ChIP-Seq_HepG2_Human0.96839828
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96663690
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96663690
127P300_19829295_ChIP-Seq_ESCs_Human0.96503330
128SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96441622
129* GATA6_21074721_ChIP-Seq_CACO-2_Human0.96163404
130* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96144471
131* CTCF_27219007_Chip-Seq_Bcells_Human0.95830111
132NFYA_21822215_ChIP-Seq_K562_Human0.95564162
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95494611
134* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95122838
135* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94653688
136CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93410713
137PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90470125
138SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90106992
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89738451
140* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88640550
141HNF4A_19822575_ChIP-Seq_HepG2_Human0.88155860
142AHR_22903824_ChIP-Seq_MCF-7_Human0.88138207
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87948880
144SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87206953
145BCAT_22108803_ChIP-Seq_LS180_Human0.86420660
146RXR_22108803_ChIP-Seq_LS180_Human0.85201705
147* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84512222
148FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.83852031
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83216418
150BCOR_27268052_Chip-Seq_Bcells_Human0.82974504
151TP63_23658742_ChIP-Seq_EP156T_Human0.82775791
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79375825
153* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.78576547
154GATA1_19941826_ChIP-Seq_K562_Human0.78249921
155KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77466390
156EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.76577936
157JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76316546
158* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.75379220
159CTCF_20526341_ChIP-Seq_ESCs_Human0.75287980
160GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75164442
161EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.74853451
162CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74389677
163CDX2_22108803_ChIP-Seq_LS180_Human0.73297779
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72981429
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.72795583
166EGR1_19032775_ChIP-ChIP_M12_Human0.72428005
167FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71398696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.61349073
2MP0003283_abnormal_digestive_organ5.28326079
3MP0005360_urolithiasis5.17796021
4MP0001666_abnormal_nutrient_absorption4.41005690
5MP0004264_abnormal_extraembryonic_tissu3.95269889
6MP0000462_abnormal_digestive_system3.62377972
7MP0003183_abnormal_peptide_metabolism3.54156952
8MP0003866_abnormal_defecation2.93660580
9MP0004043_abnormal_pH_regulation2.82747903
10MP0003195_calcinosis2.80744076
11MP0002822_catalepsy2.68498730
12MP0003878_abnormal_ear_physiology2.45458192
13MP0005377_hearing/vestibular/ear_phenot2.45458192
14MP0002796_impaired_skin_barrier2.23486555
15MP0002234_abnormal_pharynx_morphology2.19399134
16MP0003252_abnormal_bile_duct2.17578017
17MP0005085_abnormal_gallbladder_physiolo2.10230264
18MP0002139_abnormal_hepatobiliary_system2.08169502
19MP0009840_abnormal_foam_cell1.99681028
20MP0008875_abnormal_xenobiotic_pharmacok1.96249246
21MP0001664_abnormal_digestion1.83349340
22MP0004885_abnormal_endolymph1.82421996
23MP0002909_abnormal_adrenal_gland1.82256416
24MP0005381_digestive/alimentary_phenotyp1.79595113
25MP0005084_abnormal_gallbladder_morpholo1.78894758
26MP0000538_abnormal_urinary_bladder1.78066589
27MP0000013_abnormal_adipose_tissue1.71436553
28MP0004019_abnormal_vitamin_homeostasis1.70296106
29MP0003705_abnormal_hypodermis_morpholog1.70106534
30MP0002277_abnormal_respiratory_mucosa1.69645221
31MP0003300_gastrointestinal_ulcer1.65921352
32MP0002254_reproductive_system_inflammat1.63937517
33MP0000537_abnormal_urethra_morphology1.62756260
34MP0010678_abnormal_skin_adnexa1.61610742
35MP0001765_abnormal_ion_homeostasis1.60731915
36MP0002098_abnormal_vibrissa_morphology1.59936618
37MP0009780_abnormal_chondrocyte_physiolo1.56409127
38MP0000678_abnormal_parathyroid_gland1.56214626
39MP0001501_abnormal_sleep_pattern1.55051560
40MP0003724_increased_susceptibility_to1.53034294
41MP0000477_abnormal_intestine_morphology1.52348729
42MP0010352_gastrointestinal_tract_polyps1.49617983
43MP0001663_abnormal_digestive_system1.48825765
44MP0008872_abnormal_physiological_respon1.47595656
45MP0009643_abnormal_urine_homeostasis1.43679740
46MP0001764_abnormal_homeostasis1.42740160
47MP0002163_abnormal_gland_morphology1.42618956
48MP0006082_CNS_inflammation1.42416841
49MP0010329_abnormal_lipoprotein_level1.41717963
50MP0001986_abnormal_taste_sensitivity1.39546344
51MP0002877_abnormal_melanocyte_morpholog1.39104548
52MP0005075_abnormal_melanosome_morpholog1.38447158
53MP0001849_ear_inflammation1.38193012
54MP0009053_abnormal_anal_canal1.37164025
55MP0001873_stomach_inflammation1.36043823
56MP0010155_abnormal_intestine_physiology1.35237084
57MP0000467_abnormal_esophagus_morphology1.35165644
58MP0006054_spinal_hemorrhage1.30776694
59MP0005365_abnormal_bile_salt1.30057968
60MP0005645_abnormal_hypothalamus_physiol1.26609433
61MP0005501_abnormal_skin_physiology1.24052783
62MP0000579_abnormal_nail_morphology1.23250666
63MP0002876_abnormal_thyroid_physiology1.22669085
64MP0003787_abnormal_imprinting1.21855645
65MP0004947_skin_inflammation1.21270845
66MP0000685_abnormal_immune_system1.21252312
67MP0005379_endocrine/exocrine_gland_phen1.17954226
68MP0005167_abnormal_blood-brain_barrier1.17760388
69MP0002693_abnormal_pancreas_physiology1.17587346
70MP0005387_immune_system_phenotype1.16181344
71MP0001790_abnormal_immune_system1.16181344
72MP0005671_abnormal_response_to1.15493000
73MP0001485_abnormal_pinna_reflex1.15246763
74MP0000613_abnormal_salivary_gland1.14845597
75MP0001944_abnormal_pancreas_morphology1.13422414
76MP0005636_abnormal_mineral_homeostasis1.11780734
77MP0003315_abnormal_perineum_morphology1.09840019
78MP0009785_altered_susceptibility_to1.09676039
79MP0001188_hyperpigmentation1.07702122
80MP0001756_abnormal_urination1.07616068
81MP0002837_dystrophic_cardiac_calcinosis1.05062323
82MP0000003_abnormal_adipose_tissue1.04712841
83MP0005551_abnormal_eye_electrophysiolog1.02406736
84MP0010386_abnormal_urinary_bladder0.98504684
85MP0003453_abnormal_keratinocyte_physiol0.98302871
86MP0008004_abnormal_stomach_pH0.97738180
87MP0004270_analgesia0.97605964
88MP0002166_altered_tumor_susceptibility0.97294678
89MP0001216_abnormal_epidermal_layer0.97060774
90MP0003191_abnormal_cellular_cholesterol0.94905475
91MP0001845_abnormal_inflammatory_respons0.94403659
92MP0000490_abnormal_crypts_of0.94098495
93MP0005448_abnormal_energy_balance0.93255100
94MP0005310_abnormal_salivary_gland0.91890057
95MP0000230_abnormal_systemic_arterial0.90700298
96MP0005646_abnormal_pituitary_gland0.89506473
97MP0005166_decreased_susceptibility_to0.88115714
98MP0002928_abnormal_bile_duct0.86810840
99MP0003566_abnormal_cell_adhesion0.85192930
100MP0003045_fibrosis0.84913484
101MP0003806_abnormal_nucleotide_metabolis0.84810835
102MP0001800_abnormal_humoral_immune0.83869028
103MP0002060_abnormal_skin_morphology0.83775901
104MP0005174_abnormal_tail_pigmentation0.83652888
105MP0000465_gastrointestinal_hemorrhage0.81345210
106MP0002896_abnormal_bone_mineralization0.81166781
107MP0002138_abnormal_hepatobiliary_system0.80922931
108MP0005220_abnormal_exocrine_pancreas0.80888386
109MP0002078_abnormal_glucose_homeostasis0.80866569
110MP0000015_abnormal_ear_pigmentation0.80786085
111MP0009379_abnormal_foot_pigmentation0.79740252
112MP0003638_abnormal_response/metabolism_0.79510511
113MP0001835_abnormal_antigen_presentation0.79408348
114MP0002118_abnormal_lipid_homeostasis0.78216590
115MP0005025_abnormal_response_to0.78062509
116MP0003879_abnormal_hair_cell0.75752013
117MP0003868_abnormal_feces_composition0.75558306
118MP0000470_abnormal_stomach_morphology0.75456868
119MP0003011_delayed_dark_adaptation0.75419786
120MP0005535_abnormal_body_temperature0.75377602
121MP0000377_abnormal_hair_follicle0.72782819
122MP0000762_abnormal_tongue_morphology0.71569180
123MP0004858_abnormal_nervous_system0.71268695
124MP0005275_abnormal_skin_tensile0.70477499
125MP0000516_abnormal_urinary_system0.69139372
126MP0005367_renal/urinary_system_phenotyp0.69139372
127MP0008961_abnormal_basal_metabolism0.67541877
128MP0003953_abnormal_hormone_level0.66931522
129MP0000427_abnormal_hair_cycle0.64389742
130MP0010771_integument_phenotype0.64121079
131MP0009384_cardiac_valve_regurgitation0.63421637
132MP0000383_abnormal_hair_follicle0.62430198
133MP0002136_abnormal_kidney_physiology0.62174033
134MP0003941_abnormal_skin_development0.59674257
135MP0005332_abnormal_amino_acid0.57627091
136MP0004147_increased_porphyrin_level0.53925704
137MP0000609_abnormal_liver_physiology0.53794793
138MP0001191_abnormal_skin_condition0.53268375
139MP0004782_abnormal_surfactant_physiolog0.47618868
140MP0009642_abnormal_blood_homeostasis0.44197972

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)5.45479752
2Flat acetabular roof (HP:0003180)4.80781582
3Cupped ribs (HP:0000887)4.68248274
4Ileus (HP:0002595)4.62363884
5Abdominal distention (HP:0003270)4.48418898
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.05654266
7Fragile nails (HP:0001808)3.87105510
8Hyperactive renin-angiotensin system (HP:0000841)3.84617607
9Conjugated hyperbilirubinemia (HP:0002908)3.76545924
10Abnormality of the distal phalanx of the thumb (HP:0009617)3.73896104
11Woolly hair (HP:0002224)3.71650087
12Symphalangism affecting the phalanges of the hand (HP:0009773)3.62843835
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57672148
14Symptomatic seizures (HP:0011145)3.52174594
15Abnormality of the 1st metacarpal (HP:0010009)3.39945677
16Malnutrition (HP:0004395)3.33358879
17Milia (HP:0001056)3.23666612
18Hyperinsulinemic hypoglycemia (HP:0000825)3.22009988
19Abnormality of chloride homeostasis (HP:0011422)3.21121686
20Pili torti (HP:0003777)3.18474583
21Congenital sensorineural hearing impairment (HP:0008527)3.13113812
22Neonatal short-limb short stature (HP:0008921)3.11704575
23Abnormality of vitamin B metabolism (HP:0004340)3.09258044
24Late onset (HP:0003584)3.07813258
25Flat capital femoral epiphysis (HP:0003370)3.07196421
26Onycholysis (HP:0001806)3.05094692
27Hyperparathyroidism (HP:0000843)3.01748489
28Posterior subcapsular cataract (HP:0007787)2.99572280
29Hydroxyprolinuria (HP:0003080)2.98991734
30Abnormality of proline metabolism (HP:0010907)2.98991734
31Flattened epiphyses (HP:0003071)2.97118040
32Abnormality of carpal bone ossification (HP:0006257)2.93510740
33Hypoglycemic seizures (HP:0002173)2.89251111
34Hypoglycemic coma (HP:0001325)2.86006090
35Acanthocytosis (HP:0001927)2.85817774
36Abnormality of the vitamin B12 metabolism (HP:0004341)2.82889887
37Hypothermia (HP:0002045)2.78828977
38Alkalosis (HP:0001948)2.73882305
39Pustule (HP:0200039)2.71866435
40Abnormal tarsal ossification (HP:0008369)2.70847792
41Abnormality of small intestinal villus morphology (HP:0011472)2.70364192
42Villous atrophy (HP:0011473)2.70364192
43Hypomagnesemia (HP:0002917)2.69095076
44Pigmentary retinal degeneration (HP:0001146)2.68892710
45Abnormality of the renal cortex (HP:0011035)2.68797182
46Increased IgE level (HP:0003212)2.66017993
47Palmoplantar hyperkeratosis (HP:0000972)2.65935617
48Abnormal pancreas size (HP:0012094)2.63659095
49Abnormality of calcium-phosphate metabolism (HP:0100530)2.62358281
50Mildly elevated creatine phosphokinase (HP:0008180)2.59347994
51Spinal cord compression (HP:0002176)2.59323450
52Dehydration (HP:0001944)2.58845855
53Congenital stationary night blindness (HP:0007642)2.58535629
54Hypobetalipoproteinemia (HP:0003563)2.56763623
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.56198988
56Vertebral hypoplasia (HP:0008417)2.56198988
57Hypoplasia of the uterus (HP:0000013)2.54421407
58Plantar hyperkeratosis (HP:0007556)2.54180375
59Ketosis (HP:0001946)2.51450089
60Abnormality of magnesium homeostasis (HP:0004921)2.50676040
61Vertebral clefting (HP:0008428)2.48964679
62Aplasia/hypoplasia of the uterus (HP:0008684)2.48703244
63Abnormal biliary tract morphology (HP:0012440)2.48135102
64Furrowed tongue (HP:0000221)2.45310216
65Progressive sensorineural hearing impairment (HP:0000408)2.44226615
66Abnormality of renin-angiotensin system (HP:0000847)2.44073775
67Hyperglycemia (HP:0003074)2.43685834
68Abnormality of vitamin metabolism (HP:0100508)2.42352562
69Palmar hyperkeratosis (HP:0010765)2.42110170
70Potter facies (HP:0002009)2.41877138
71Facial shape deformation (HP:0011334)2.41877138
72Palpitations (HP:0001962)2.40910022
73Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.40858485
74Curly hair (HP:0002212)2.40511056
75Ventricular fibrillation (HP:0001663)2.37293003
76Chronic diarrhea (HP:0002028)2.36943620
77Autoimmune thrombocytopenia (HP:0001973)2.36857679
78Hyperaldosteronism (HP:0000859)2.35946720
79Large for gestational age (HP:0001520)2.35154828
80Pancreatic cysts (HP:0001737)2.35050640
81Abnormal hand bone ossification (HP:0010660)2.35038581
82Widely patent fontanelles and sutures (HP:0004492)2.34733168
83Atrophic scars (HP:0001075)2.33713369
84Hoarse voice (HP:0001609)2.32411547
85Ketoacidosis (HP:0001993)2.31919009
86Biliary tract neoplasm (HP:0100574)2.30368045
87Short phalanx of the thumb (HP:0009660)2.30152973
88Abnormality of urine glucose concentration (HP:0011016)2.29838296
89Glycosuria (HP:0003076)2.29838296
90Tetany (HP:0001281)2.25450902
91Metabolic alkalosis (HP:0200114)2.24488836
92Chronic bronchitis (HP:0004469)2.24420212
93Hypokalemia (HP:0002900)2.22809307
94Fat malabsorption (HP:0002630)2.22715869
95Bronchiectasis (HP:0002110)2.19311337
96Hyperventilation (HP:0002883)2.19306532
97Stomatitis (HP:0010280)2.17295811
98Abnormality of the phalanges of the hallux (HP:0010057)2.16464550
99Abnormality of the proximal phalanges of the hand (HP:0009834)2.14931008
100Hypoplasia of dental enamel (HP:0006297)2.14432661
101Abnormal albumin level (HP:0012116)2.14092453
102Hypoalbuminemia (HP:0003073)2.14092453
103Hyperphosphaturia (HP:0003109)2.14033753
104Nasal polyposis (HP:0100582)2.12936088
105Abnormal vertebral ossification (HP:0100569)2.12839111
106Tubular atrophy (HP:0000092)2.12731710
107Abnormal ossification of hand bones (HP:0005921)2.12073403
108Hyperphosphatemia (HP:0002905)2.11137061
109Abnormal cartilage morphology (HP:0002763)2.10708311
110Absent/shortened dynein arms (HP:0200106)2.10421330
111Dynein arm defect of respiratory motile cilia (HP:0012255)2.10421330
112Short middle phalanx of finger (HP:0005819)2.10015684
113Abnormality of purine metabolism (HP:0004352)2.09817598
114Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09413556
115Abnormal rod and cone electroretinograms (HP:0008323)2.08854385
116Insulin-resistant diabetes mellitus (HP:0000831)2.08321931
117Abnormality of the gastric mucosa (HP:0004295)2.07092853
118Autoimmune hemolytic anemia (HP:0001890)2.06846784
119Urinary glycosaminoglycan excretion (HP:0003541)2.06592718
120Mucopolysacchariduria (HP:0008155)2.06592718
121Flared iliac wings (HP:0002869)2.05581029
122Decreased circulating renin level (HP:0003351)2.04314623
123Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.02539602
124Micronodular cirrhosis (HP:0001413)2.01764338
125Goiter (HP:0000853)2.01761537
126Abnormality of renal excretion (HP:0011036)2.01728449
127Attenuation of retinal blood vessels (HP:0007843)2.00971291
128Polydipsia (HP:0001959)2.00803764
129Abnormal drinking behavior (HP:0030082)2.00803764
130Alopecia of scalp (HP:0002293)2.00715033
131True hermaphroditism (HP:0010459)2.00452521
132Eczematoid dermatitis (HP:0000976)1.98792520
133Hyperkalemia (HP:0002153)1.98564710
134Abnormality of potassium homeostasis (HP:0011042)1.96398813
135Breech presentation (HP:0001623)1.95696972
136Pterygium (HP:0001059)1.95577740
137Stomach cancer (HP:0012126)1.95307579
138Abnormal foot bone ossification (HP:0010675)1.95150532
139Abnormal respiratory epithelium morphology (HP:0012253)1.94304048
140Abnormal respiratory motile cilium morphology (HP:0005938)1.94304048
141Abnormal hair laboratory examination (HP:0003328)1.93623385
142Focal segmental glomerulosclerosis (HP:0000097)1.92385744
143Progressive hearing impairment (HP:0001730)1.91781447
144Syncope (HP:0001279)1.91716302
145Confusion (HP:0001289)1.90121062
146Exocrine pancreatic insufficiency (HP:0001738)1.89872410
147Nephrolithiasis (HP:0000787)1.89719379
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89633782
149Abnormality of the renal medulla (HP:0100957)1.89480059
150Increased circulating renin level (HP:0000848)1.88632118
151Pancreatic fibrosis (HP:0100732)1.86393556
152Hamartoma of the eye (HP:0010568)1.84417182
153Renal salt wasting (HP:0000127)1.82718608
154Conjunctival hamartoma (HP:0100780)1.82085407
155Abnormality of macular pigmentation (HP:0008002)1.81907443
156Renal cortical cysts (HP:0000803)1.81482369
157Chronic otitis media (HP:0000389)1.81252772
158Abnormal ciliary motility (HP:0012262)1.80929502
159Nephronophthisis (HP:0000090)1.77695661
160Abnormal respiratory motile cilium physiology (HP:0012261)1.76481663
161Abnormality of the nasal mucosa (HP:0000433)1.75008811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK36.83785062
2MST1R4.49775296
3FRK4.25681839
4EPHB23.30965337
5ACVR1B3.29701565
6MST43.13508815
7BMPR1B3.11297404
8MAP2K23.03750265
9MAP3K22.90490335
10EPHA22.46923973
11LMTK22.29942828
12MAPK152.29942172
13STK242.27266914
14MET2.23097479
15GRK12.15084324
16PTK62.13080477
17RIPK12.11657042
18IRAK12.05848211
19MAP4K22.05165311
20ADRBK22.05032330
21OXSR12.04175765
22INSRR2.01965189
23PIK3CA2.01684094
24TESK11.98839589
25PRKG21.96047432
26ERN11.85559423
27WNK41.84779987
28NME11.84464857
29KSR21.81541472
30MAP4K11.78547331
31STK391.67805093
32WNK31.65613943
33TXK1.58316549
34PINK11.56219955
35PTK21.55935657
36TAOK11.53761272
37FER1.51855213
38FGFR21.49783413
39AKT31.49608568
40MAP3K11.46625982
41PASK1.38259900
42GRK61.34106704
43MAP3K91.32495462
44STK38L1.31832134
45IKBKB1.22381482
46MAP2K11.18969044
47MAP3K101.18200232
48PRKCI1.13141902
49FGFR31.09565518
50DAPK21.06711753
51TYK21.03848830
52EPHB11.03530669
53MAP3K121.00625251
54ADRBK10.99248279
55PRKD30.99165977
56PIK3CG0.97577711
57EPHA30.93906083
58DDR20.93477744
59BRAF0.90627228
60DYRK1B0.90586297
61ARAF0.89688400
62ICK0.89226144
63CASK0.89078323
64MATK0.88246076
65PRKCQ0.86953658
66MYLK0.86852101
67FLT30.82551163
68PHKG10.80922303
69PHKG20.80922303
70NTRK10.80832545
71IRAK40.80495309
72PDGFRA0.77472027
73TRPM70.77174939
74CDC42BPA0.72222467
75TNK20.71826145
76ERBB40.70771318
77HIPK20.69996693
78PTK2B0.67869800
79PAK40.67236621
80STK110.65959721
81TRIB30.65783023
82CAMK2D0.65146775
83MAP3K30.64826447
84IKBKE0.64260804
85PAK30.64110893
86ZAK0.63848486
87JAK10.59389787
88MUSK0.58848585
89MAP3K40.56000486
90MAP3K140.55877950
91LATS10.55352429
92PRKCZ0.55309028
93MAPK130.55238157
94RIPK40.52771406
95MAP2K60.52178591
96TNIK0.51914222
97TESK20.51182989
98LIMK10.51135704
99NUAK10.51126794
100ERBB20.50641943
101CAMKK20.50433898
102STK380.49787460
103TLK10.49483830
104STK30.48308405
105ERBB30.48145181
106CHUK0.44522662
107PDPK10.43790860
108TEC0.43687864
109FGFR40.43341602
110RET0.42112288
111CSK0.38444825
112MAP3K110.38370232
113LYN0.38259938
114TGFBR10.36411459
115MAP3K80.35632628
116SYK0.35473699
117SCYL20.35348999
118LCK0.35113759
119WNK10.34159662
120BMPR20.34085493
121CAMK2B0.34058904
122ZAP700.33333834
123PKN20.32608766
124MAP3K130.31816458
125BLK0.31678029
126NLK0.31596409
127PRKAA20.31375021
128PRKD20.30804183
129PRKACA0.30268935
130ABL10.30052089
131NTRK30.30003003
132SRC0.29982796
133MAPK110.29660488
134PRKAA10.29623729
135PRKCA0.27893346
136MAPKAPK20.26346433
137PIM20.25198309
138MAPKAPK30.24636623
139BMX0.24609665
140CAMK2G0.23083150
141PDK10.22052972
142LRRK20.21993600
143ITK0.21814221
144MAP3K70.21094881
145GSK3A0.20908862
146CSNK1A10.20256512
147PRKCE0.18840987
148PRKACG0.17732454
149PDGFRB0.16361824
150CDK50.15228923
151FGFR10.12591377
152RPS6KA10.11098330
153JAK20.09450442
154STK100.09332937

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.44008440
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.72359392
3Fat digestion and absorption_Homo sapiens_hsa049754.33606153
4Mineral absorption_Homo sapiens_hsa049783.90023953
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.42578963
6Renin-angiotensin system_Homo sapiens_hsa046142.73872660
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.47852101
8Carbohydrate digestion and absorption_Homo sapiens_hsa049732.40225419
9Galactose metabolism_Homo sapiens_hsa000522.25265943
10Vitamin digestion and absorption_Homo sapiens_hsa049772.16585330
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08307905
12Nitrogen metabolism_Homo sapiens_hsa009101.93256109
13Bile secretion_Homo sapiens_hsa049761.86704788
14Protein digestion and absorption_Homo sapiens_hsa049741.81364748
15Retinol metabolism_Homo sapiens_hsa008301.79938554
16Caffeine metabolism_Homo sapiens_hsa002321.69764735
17Type I diabetes mellitus_Homo sapiens_hsa049401.64837315
18Starch and sucrose metabolism_Homo sapiens_hsa005001.64110582
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60584961
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.56062039
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.56061246
22Fructose and mannose metabolism_Homo sapiens_hsa000511.54169038
23Histidine metabolism_Homo sapiens_hsa003401.54144859
24Folate biosynthesis_Homo sapiens_hsa007901.50115117
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.48836869
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.47515160
27Insulin secretion_Homo sapiens_hsa049111.44171284
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.34208910
29Phototransduction_Homo sapiens_hsa047441.34111656
30Thyroid hormone synthesis_Homo sapiens_hsa049181.22738816
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21764799
32Peroxisome_Homo sapiens_hsa041461.20580983
33Pancreatic secretion_Homo sapiens_hsa049721.17791139
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17568275
35Graft-versus-host disease_Homo sapiens_hsa053321.09184448
36Sphingolipid metabolism_Homo sapiens_hsa006001.09141375
37Type II diabetes mellitus_Homo sapiens_hsa049301.03560769
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02761492
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02470886
40Tryptophan metabolism_Homo sapiens_hsa003801.01963008
41Linoleic acid metabolism_Homo sapiens_hsa005911.00721243
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97103571
43Allograft rejection_Homo sapiens_hsa053300.96474140
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.93996311
45Vibrio cholerae infection_Homo sapiens_hsa051100.92945515
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89058753
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88537662
48Glycerolipid metabolism_Homo sapiens_hsa005610.88505994
49Tight junction_Homo sapiens_hsa045300.87425561
50Thyroid cancer_Homo sapiens_hsa052160.87070483
51Glutathione metabolism_Homo sapiens_hsa004800.86719187
52Autoimmune thyroid disease_Homo sapiens_hsa053200.86484987
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85928172
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85033686
55Sulfur relay system_Homo sapiens_hsa041220.84095933
56ABC transporters_Homo sapiens_hsa020100.83645435
57Fatty acid degradation_Homo sapiens_hsa000710.83552625
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83116875
59PPAR signaling pathway_Homo sapiens_hsa033200.81883090
60Bladder cancer_Homo sapiens_hsa052190.81135768
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81019615
62Regulation of autophagy_Homo sapiens_hsa041400.79641527
63Collecting duct acid secretion_Homo sapiens_hsa049660.76006420
64Butanoate metabolism_Homo sapiens_hsa006500.74162945
65Circadian rhythm_Homo sapiens_hsa047100.71404900
66Protein export_Homo sapiens_hsa030600.70813168
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.67923966
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65564988
69Ovarian steroidogenesis_Homo sapiens_hsa049130.64404732
70Gastric acid secretion_Homo sapiens_hsa049710.63868667
71Asthma_Homo sapiens_hsa053100.62557149
72Salivary secretion_Homo sapiens_hsa049700.62346543
73Primary immunodeficiency_Homo sapiens_hsa053400.59853289
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59754211
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59496994
76Cocaine addiction_Homo sapiens_hsa050300.58757753
77Staphylococcus aureus infection_Homo sapiens_hsa051500.55830774
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54994011
79N-Glycan biosynthesis_Homo sapiens_hsa005100.53190190
80Serotonergic synapse_Homo sapiens_hsa047260.50547456
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50433515
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50331842
83Arachidonic acid metabolism_Homo sapiens_hsa005900.45104011
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44255053
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43024291
86Arginine and proline metabolism_Homo sapiens_hsa003300.42307239
87Oxidative phosphorylation_Homo sapiens_hsa001900.40680214
88Chemical carcinogenesis_Homo sapiens_hsa052040.39641394
89Alzheimers disease_Homo sapiens_hsa050100.38398716
90Propanoate metabolism_Homo sapiens_hsa006400.38361080
91Adherens junction_Homo sapiens_hsa045200.38078950
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38072300
93Hepatitis C_Homo sapiens_hsa051600.37926164
94Estrogen signaling pathway_Homo sapiens_hsa049150.37715627
95Pyruvate metabolism_Homo sapiens_hsa006200.37100075
96Antigen processing and presentation_Homo sapiens_hsa046120.36900568
97African trypanosomiasis_Homo sapiens_hsa051430.36207740
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35777658
99Ether lipid metabolism_Homo sapiens_hsa005650.35751148
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34916272
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.34657669
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34478341
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.34184146
104Endometrial cancer_Homo sapiens_hsa052130.34057698
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.33260068
106Other glycan degradation_Homo sapiens_hsa005110.33150105
107Taste transduction_Homo sapiens_hsa047420.32301031
108GnRH signaling pathway_Homo sapiens_hsa049120.31874893
109Renin secretion_Homo sapiens_hsa049240.31520248
110Selenocompound metabolism_Homo sapiens_hsa004500.31498377
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30698329
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30519913
113Phenylalanine metabolism_Homo sapiens_hsa003600.30077029
114Prolactin signaling pathway_Homo sapiens_hsa049170.28795362
115Insulin resistance_Homo sapiens_hsa049310.28691352
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.27568638
117Fatty acid metabolism_Homo sapiens_hsa012120.24291150
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24156262
119Dorso-ventral axis formation_Homo sapiens_hsa043200.23913605
120Pentose phosphate pathway_Homo sapiens_hsa000300.23876768
121Arginine biosynthesis_Homo sapiens_hsa002200.23164452
122Amphetamine addiction_Homo sapiens_hsa050310.22655375
123Rheumatoid arthritis_Homo sapiens_hsa053230.22183743
124VEGF signaling pathway_Homo sapiens_hsa043700.21466499
125Tyrosine metabolism_Homo sapiens_hsa003500.21408005
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21327229
127Parkinsons disease_Homo sapiens_hsa050120.20792022
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20079656
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18947660
130Lysosome_Homo sapiens_hsa041420.18376113
131Salmonella infection_Homo sapiens_hsa051320.18342627
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18308288
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.18305907
134Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17713310
135Choline metabolism in cancer_Homo sapiens_hsa052310.17595084
136beta-Alanine metabolism_Homo sapiens_hsa004100.17473874
137Amoebiasis_Homo sapiens_hsa051460.17282016
138Metabolic pathways_Homo sapiens_hsa011000.17159517

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