TTC27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.11253779
2folic acid-containing compound biosynthetic process (GO:0009396)4.95409471
3DNA unwinding involved in DNA replication (GO:0006268)4.90922403
4regulation of centriole replication (GO:0046599)4.82106611
5purine nucleobase biosynthetic process (GO:0009113)4.79045015
6nuclear pore organization (GO:0006999)4.69584934
7IMP biosynthetic process (GO:0006188)4.58708045
8formation of translation preinitiation complex (GO:0001731)4.55054054
9DNA replication initiation (GO:0006270)4.47327675
10maturation of SSU-rRNA (GO:0030490)4.46082017
11DNA strand elongation involved in DNA replication (GO:0006271)4.45232579
12mitotic nuclear envelope disassembly (GO:0007077)4.39645918
13protein localization to kinetochore (GO:0034501)4.37554989
14ribosome assembly (GO:0042255)4.35981138
15nuclear pore complex assembly (GO:0051292)4.34724941
16DNA strand elongation (GO:0022616)4.23022243
17mitotic metaphase plate congression (GO:0007080)4.22503595
18ribosome biogenesis (GO:0042254)4.16313031
19nuclear envelope disassembly (GO:0051081)4.08717615
20membrane disassembly (GO:0030397)4.08717615
21IMP metabolic process (GO:0046040)4.08145353
22DNA topological change (GO:0006265)4.04111293
23DNA replication checkpoint (GO:0000076)3.97751696
24DNA replication-dependent nucleosome organization (GO:0034723)3.95816218
25DNA replication-dependent nucleosome assembly (GO:0006335)3.95816218
26establishment of integrated proviral latency (GO:0075713)3.82041541
27telomere maintenance via semi-conservative replication (GO:0032201)3.77698644
28ribonucleoprotein complex biogenesis (GO:0022613)3.73594921
29DNA ligation (GO:0006266)3.72179237
30metaphase plate congression (GO:0051310)3.70932556
31ribosomal large subunit biogenesis (GO:0042273)3.69997014
32protein localization to chromosome, centromeric region (GO:0071459)3.65913462
33ribosomal small subunit assembly (GO:0000028)3.63560844
34chromatin remodeling at centromere (GO:0031055)3.57985893
35CENP-A containing nucleosome assembly (GO:0034080)3.54646278
36regulation of spindle organization (GO:0090224)3.51627470
37rRNA processing (GO:0006364)3.48905545
38double-strand break repair via nonhomologous end joining (GO:0006303)3.47828498
39non-recombinational repair (GO:0000726)3.47828498
40DNA duplex unwinding (GO:0032508)3.43820880
41mitotic chromosome condensation (GO:0007076)3.43594334
42regulation of translational termination (GO:0006449)3.43462102
43DNA geometric change (GO:0032392)3.42958008
44telomere maintenance via recombination (GO:0000722)3.41114258
45folic acid metabolic process (GO:0046655)3.40521318
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39199062
47spliceosomal snRNP assembly (GO:0000387)3.38717518
48rRNA metabolic process (GO:0016072)3.38163884
49mitotic sister chromatid segregation (GO:0000070)3.37132962
50DNA replication-independent nucleosome assembly (GO:0006336)3.36512766
51DNA replication-independent nucleosome organization (GO:0034724)3.36512766
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36483027
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.35029988
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34563297
55peptidyl-arginine omega-N-methylation (GO:0035247)3.34233830
56mitotic recombination (GO:0006312)3.31402670
57pore complex assembly (GO:0046931)3.31361568
58somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31131273
59somatic hypermutation of immunoglobulin genes (GO:0016446)3.31131273
60establishment of chromosome localization (GO:0051303)3.30776389
61translational initiation (GO:0006413)3.30105500
62amino acid activation (GO:0043038)3.29098226
63tRNA aminoacylation (GO:0043039)3.29098226
64attachment of spindle microtubules to kinetochore (GO:0008608)3.28399932
65positive regulation of chromosome segregation (GO:0051984)3.26796802
66positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.25678704
67regulation of sister chromatid segregation (GO:0033045)3.25436881
68regulation of mitotic sister chromatid separation (GO:0010965)3.25436881
69regulation of mitotic sister chromatid segregation (GO:0033047)3.25436881
70pseudouridine synthesis (GO:0001522)3.21772193
71translational termination (GO:0006415)3.21365289
72nuclear envelope organization (GO:0006998)3.19243911
73DNA deamination (GO:0045006)3.18169687
74viral transcription (GO:0019083)3.15709838
75telomere maintenance via telomere lengthening (GO:0010833)3.15295929
76regulation of centrosome duplication (GO:0010824)3.14386886
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13883098
78histone exchange (GO:0043486)3.13788753
79sister chromatid segregation (GO:0000819)3.13280600
80rRNA modification (GO:0000154)3.10967436
81rRNA methylation (GO:0031167)3.10706136
82replication fork processing (GO:0031297)3.09144593
83translational elongation (GO:0006414)3.08702694
84mitotic sister chromatid cohesion (GO:0007064)3.07492820
85regulation of histone H3-K9 methylation (GO:0051570)3.04544477
86cullin deneddylation (GO:0010388)3.04280615
87regulation of translational fidelity (GO:0006450)3.03775599
88negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03675496
89negative regulation of ligase activity (GO:0051352)3.03675496
90regulation of centrosome cycle (GO:0046605)3.01745178
91maturation of 5.8S rRNA (GO:0000460)3.01673388
92regulation of chromosome segregation (GO:0051983)3.01179706
93negative regulation of chromosome segregation (GO:0051985)3.00842687
94chromatin assembly or disassembly (GO:0006333)3.00002151
95kinetochore assembly (GO:0051382)2.99802032
96histone arginine methylation (GO:0034969)2.96585433
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96247966
98negative regulation of sister chromatid segregation (GO:0033046)2.96247966
99negative regulation of mitotic sister chromatid separation (GO:2000816)2.96247966
100negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96247966
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95728906
102DNA double-strand break processing (GO:0000729)2.95464353
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.95258783
104nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.95199041
105ribosomal small subunit biogenesis (GO:0042274)2.94861175
106spindle checkpoint (GO:0031577)2.93800180
107DNA catabolic process, exonucleolytic (GO:0000738)2.93413177
108spindle assembly checkpoint (GO:0071173)2.92998627
109mitotic spindle assembly checkpoint (GO:0007094)2.92720744
110regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92410436
111regulation of translation in response to stress (GO:0043555)2.91440294
112kinetochore organization (GO:0051383)2.90331745
113regulation of mitotic spindle organization (GO:0060236)2.90298011
114peptidyl-arginine methylation (GO:0018216)2.90289156
115peptidyl-arginine N-methylation (GO:0035246)2.90289156
116centriole replication (GO:0007099)2.90269253
117chromosome segregation (GO:0007059)2.89456196
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.88902639
119mitotic spindle checkpoint (GO:0071174)2.88142036
120DNA strand renaturation (GO:0000733)2.88123518
121tetrahydrofolate metabolic process (GO:0046653)2.87578387
122tRNA aminoacylation for protein translation (GO:0006418)2.87272343
123pteridine-containing compound biosynthetic process (GO:0042559)2.87219808
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.86821719
125protein K6-linked ubiquitination (GO:0085020)2.86355037
126RNA splicing, via transesterification reactions (GO:0000375)2.85286842
127negative regulation of histone methylation (GO:0031061)2.84838600
128proteasome assembly (GO:0043248)2.84173944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.69215585
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.53209604
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.93875014
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74458828
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58689357
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.18126356
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00138580
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.92174054
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.86798585
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86160137
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82723328
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.77241100
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68305990
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.67669091
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56583657
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.43652116
17XRN2_22483619_ChIP-Seq_HELA_Human2.37921784
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25314331
19VDR_23849224_ChIP-Seq_CD4+_Human2.22547584
20AR_21909140_ChIP-Seq_LNCAP_Human2.22307027
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17488070
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17324792
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06836237
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.06642604
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03484592
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.98614870
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.96725035
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96391058
29DCP1A_22483619_ChIP-Seq_HELA_Human1.95272927
30FOXP3_21729870_ChIP-Seq_TREG_Human1.94126460
31* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91033089
32GABP_19822575_ChIP-Seq_HepG2_Human1.89562228
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87762912
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85889399
35TTF2_22483619_ChIP-Seq_HELA_Human1.78953653
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78683335
37MYC_22102868_ChIP-Seq_BL_Human1.77823441
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68225105
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67469735
40* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67410483
41KDM5A_27292631_Chip-Seq_BREAST_Human1.63088714
42CIITA_25753668_ChIP-Seq_RAJI_Human1.62314730
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59600847
44* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57212161
45ELK1_19687146_ChIP-ChIP_HELA_Human1.56694575
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53947585
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52794323
48* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51308302
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51227684
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49033326
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47304103
52GATA1_22025678_ChIP-Seq_K562_Human1.47302249
53* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47077504
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46804331
55SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38380880
56* YY1_21170310_ChIP-Seq_MESCs_Mouse1.37645406
57PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37620615
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35883291
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34570819
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32601516
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30433415
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30358728
63TFEB_21752829_ChIP-Seq_HELA_Human1.25587593
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23811730
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23456062
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22112621
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21551157
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21114106
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20589109
70* SRF_21415370_ChIP-Seq_HL-1_Mouse1.19895819
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18630264
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17335956
73E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15836859
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.14762515
75CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12943910
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07033465
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.06183347
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06138358
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06105377
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05422794
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05001005
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04279394
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00844178
84MYC_18940864_ChIP-ChIP_HL60_Human0.97745077
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97485581
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96624718
87KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95758875
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95301765
89CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94947909
90SOX17_20123909_ChIP-Seq_XEN_Mouse0.92467833
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91238132
92EWS_26573619_Chip-Seq_HEK293_Human0.89730677
93NANOG_21062744_ChIP-ChIP_HESCs_Human0.89662917
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.88751489
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88290880
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88027991
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87834255
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86805276
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83734150
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83004012
101VDR_21846776_ChIP-Seq_THP-1_Human0.82443792
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81177227
103ZNF263_19887448_ChIP-Seq_K562_Human0.80418983
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79843179
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79637823
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.78186069
107ELK1_22589737_ChIP-Seq_MCF10A_Human0.76668851
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76589580
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.75537428
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.73744183
111CHD1_26751641_Chip-Seq_LNCaP_Human0.71743270
112SPI1_23547873_ChIP-Seq_NB4_Human0.71665067
113MYB_26560356_Chip-Seq_TH2_Human0.69311880
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67197796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.59966490
2MP0010094_abnormal_chromosome_stability4.95919542
3MP0004957_abnormal_blastocyst_morpholog4.85569259
4MP0003111_abnormal_nucleus_morphology4.69258340
5MP0003077_abnormal_cell_cycle4.22336974
6MP0008057_abnormal_DNA_replication4.16514621
7MP0008058_abnormal_DNA_repair3.53019090
8MP0009697_abnormal_copulation3.51662212
9MP0008007_abnormal_cellular_replicative3.00181605
10MP0001730_embryonic_growth_arrest2.88331182
11MP0003123_paternal_imprinting2.88046775
12MP0010352_gastrointestinal_tract_polyps2.79538022
13MP0008932_abnormal_embryonic_tissue2.68557214
14MP0008877_abnormal_DNA_methylation2.56659555
15MP0002396_abnormal_hematopoietic_system2.48906751
16MP0000350_abnormal_cell_proliferation2.47562341
17MP0010307_abnormal_tumor_latency2.39397589
18MP0005380_embryogenesis_phenotype2.06834124
19MP0001672_abnormal_embryogenesis/_devel2.06834124
20MP0003806_abnormal_nucleotide_metabolis2.06681258
21MP0001697_abnormal_embryo_size2.01141462
22MP0003786_premature_aging2.00878216
23MP0003984_embryonic_growth_retardation1.88323474
24MP0002080_prenatal_lethality1.87730028
25MP0003718_maternal_effect1.86124489
26MP0002088_abnormal_embryonic_growth/wei1.84118782
27MP0002084_abnormal_developmental_patter1.72562405
28MP0002085_abnormal_embryonic_tissue1.69525003
29MP0000490_abnormal_crypts_of1.68767918
30MP0002086_abnormal_extraembryonic_tissu1.67773558
31MP0004197_abnormal_fetal_growth/weight/1.64545225
32MP0004808_abnormal_hematopoietic_stem1.63237015
33MP0003567_abnormal_fetal_cardiomyocyte1.55180418
34MP0000313_abnormal_cell_death1.53352912
35MP0004147_increased_porphyrin_level1.49894172
36MP0002019_abnormal_tumor_incidence1.49586202
37MP0003890_abnormal_embryonic-extraembry1.46411189
38MP0005464_abnormal_platelet_physiology1.44540580
39MP0003121_genomic_imprinting1.40412873
40MP0002210_abnormal_sex_determination1.30051748
41MP0001661_extended_life_span1.27663579
42MP0002132_abnormal_respiratory_system1.27252629
43MP0005076_abnormal_cell_differentiation1.26082455
44MP0003941_abnormal_skin_development1.20600717
45MP0001145_abnormal_male_reproductive1.19335924
46MP0005397_hematopoietic_system_phenotyp1.17991909
47MP0001545_abnormal_hematopoietic_system1.17991909
48MP0002009_preneoplasia1.17649916
49MP0000358_abnormal_cell_content/1.17512147
50MP0003943_abnormal_hepatobiliary_system1.14108113
51MP0000703_abnormal_thymus_morphology1.13804600
52MP0001929_abnormal_gametogenesis1.13363312
53MP0001293_anophthalmia1.12084555
54MP0003950_abnormal_plasma_membrane1.11579858
55MP0003705_abnormal_hypodermis_morpholog1.11521202
56MP0009333_abnormal_splenocyte_physiolog1.11280166
57MP0003315_abnormal_perineum_morphology1.09278605
58MP0009672_abnormal_birth_weight1.08304540
59MP0003656_abnormal_erythrocyte_physiolo1.07630604
60MP0003763_abnormal_thymus_physiology1.07131709
61MP0000537_abnormal_urethra_morphology1.05466644
62MP0005083_abnormal_biliary_tract1.01908348
63MP0000653_abnormal_sex_gland1.00900518
64MP0002398_abnormal_bone_marrow0.99748691
65MP0004084_abnormal_cardiac_muscle0.99673114
66MP0002722_abnormal_immune_system0.97432998
67MP0003119_abnormal_digestive_system0.97407988
68MP0003221_abnormal_cardiomyocyte_apopto0.96388989
69MP0005075_abnormal_melanosome_morpholog0.95269950
70MP0001915_intracranial_hemorrhage0.95237174
71MP0000689_abnormal_spleen_morphology0.95219593
72MP0005384_cellular_phenotype0.95153848
73MP0002006_tumorigenesis0.93856189
74MP0005621_abnormal_cell_physiology0.90758901
75MP0002160_abnormal_reproductive_system0.89071660
76MP0010030_abnormal_orbit_morphology0.88580460
77MP0005501_abnormal_skin_physiology0.86391128
78MP0005023_abnormal_wound_healing0.83704241
79MP0009703_decreased_birth_body0.83520973
80MP0000372_irregular_coat_pigmentation0.78555710
81MP0002166_altered_tumor_susceptibility0.77664905
82MP0003566_abnormal_cell_adhesion0.77642197
83MP0005389_reproductive_system_phenotype0.75579656
84MP0010234_abnormal_vibrissa_follicle0.75258458
85MP0001764_abnormal_homeostasis0.75094034
86MP0002429_abnormal_blood_cell0.73690528
87MP0002653_abnormal_ependyma_morphology0.73445673
88MP0005408_hypopigmentation0.72858743
89MP0002111_abnormal_tail_morphology0.72285418
90MP0004134_abnormal_chest_morphology0.71785474
91MP0004185_abnormal_adipocyte_glucose0.71268070
92MP0001881_abnormal_mammary_gland0.70764836
93MP0001119_abnormal_female_reproductive0.69115657
94MP0006035_abnormal_mitochondrial_morpho0.69041242
95MP0000579_abnormal_nail_morphology0.68986455
96MP0009053_abnormal_anal_canal0.67624705
97MP0000465_gastrointestinal_hemorrhage0.65995654
98MP0005266_abnormal_metabolism0.64940387
99MP0008770_decreased_survivor_rate0.64280453
100MP0000477_abnormal_intestine_morphology0.63675972
101MP0000858_altered_metastatic_potential0.63457936
102MP0002092_abnormal_eye_morphology0.62541518
103MP0005084_abnormal_gallbladder_morpholo0.60932108
104MP0005330_cardiomyopathy0.59911955
105MP0001191_abnormal_skin_condition0.58102901
106MP0004036_abnormal_muscle_relaxation0.57189665
107MP0002161_abnormal_fertility/fecundity0.57132839
108MP0004233_abnormal_muscle_weight0.56764812
109MP0003937_abnormal_limbs/digits/tail_de0.56305335
110MP0004264_abnormal_extraembryonic_tissu0.56252811
111MP0006036_abnormal_mitochondrial_physio0.56199626
112MP0000428_abnormal_craniofacial_morphol0.56084977
113MP0006054_spinal_hemorrhage0.56072334
114MP0000716_abnormal_immune_system0.55377091
115MP0001243_abnormal_dermal_layer0.54434013
116MP0000598_abnormal_liver_morphology0.54401523
117MP0002269_muscular_atrophy0.54018584
118MP0003699_abnormal_female_reproductive0.53474596
119MP0003698_abnormal_male_reproductive0.52527532
120MP0003186_abnormal_redox_activity0.51753659
121MP0005395_other_phenotype0.51508917
122MP0004133_heterotaxia0.51108748
123MP0002075_abnormal_coat/hair_pigmentati0.46242559
124MP0001286_abnormal_eye_development0.45751747
125MP0001919_abnormal_reproductive_system0.45449018
126MP0001849_ear_inflammation0.45240223
127MP0000627_abnormal_mammary_gland0.45193065
128MP0001853_heart_inflammation0.44707399
129MP0002877_abnormal_melanocyte_morpholog0.43605944

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.19496126
2Ependymoma (HP:0002888)4.31662539
3Colon cancer (HP:0003003)4.00837181
4Agnosia (HP:0010524)3.83921590
5Breast hypoplasia (HP:0003187)3.70434222
6Medulloblastoma (HP:0002885)3.69936046
7Oral leukoplakia (HP:0002745)3.63065210
8Microvesicular hepatic steatosis (HP:0001414)3.54751741
9Reticulocytopenia (HP:0001896)3.50639024
10Selective tooth agenesis (HP:0001592)3.46813486
11Abnormality of cells of the erythroid lineage (HP:0012130)3.42671681
12Increased serum pyruvate (HP:0003542)3.40680455
13Degeneration of anterior horn cells (HP:0002398)3.38952635
14Abnormality of the anterior horn cell (HP:0006802)3.38952635
15Rhabdomyosarcoma (HP:0002859)3.37030080
16Aplastic anemia (HP:0001915)3.31703050
17Nephroblastoma (Wilms tumor) (HP:0002667)3.31415873
18Cerebral hypomyelination (HP:0006808)3.25264498
19Chromsome breakage (HP:0040012)3.21394710
20Abnormality of the labia minora (HP:0012880)3.20449391
21Abnormal number of erythroid precursors (HP:0012131)3.18698204
22Increased mean platelet volume (HP:0011877)3.15650157
23Impulsivity (HP:0100710)3.14377376
24Abnormality of glycolysis (HP:0004366)3.12718561
25Embryonal renal neoplasm (HP:0011794)3.09928041
26Abnormality of chromosome stability (HP:0003220)3.01239690
27Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99505372
28Basal cell carcinoma (HP:0002671)2.97119757
29Abnormality of the astrocytes (HP:0100707)2.88546345
30Astrocytoma (HP:0009592)2.88546345
31Patellar aplasia (HP:0006443)2.86574274
32Abnormality of methionine metabolism (HP:0010901)2.80988914
33Abnormal platelet volume (HP:0011876)2.79837613
34Abnormality of the preputium (HP:0100587)2.79452181
35Carpal bone hypoplasia (HP:0001498)2.75651335
36Meckel diverticulum (HP:0002245)2.75611227
37Myelodysplasia (HP:0002863)2.72742418
38Rough bone trabeculation (HP:0100670)2.71966296
39Absent thumb (HP:0009777)2.70467153
40Aplasia/Hypoplasia of the patella (HP:0006498)2.66641327
41Abnormality of the ileum (HP:0001549)2.63741281
42Multiple enchondromatosis (HP:0005701)2.63308876
43Premature ovarian failure (HP:0008209)2.62976512
44Amaurosis fugax (HP:0100576)2.61521539
45Macrocytic anemia (HP:0001972)2.61132574
46Neoplasm of the pancreas (HP:0002894)2.59391552
47Microretrognathia (HP:0000308)2.58696092
48Combined immunodeficiency (HP:0005387)2.56709648
49Cortical dysplasia (HP:0002539)2.56456783
50Glioma (HP:0009733)2.55661480
51Short middle phalanx of the 5th finger (HP:0004220)2.52586212
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.51234372
53Reduced antithrombin III activity (HP:0001976)2.51150005
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50888397
55Abnormality of alanine metabolism (HP:0010916)2.50888397
56Hyperalaninemia (HP:0003348)2.50888397
57Biliary tract neoplasm (HP:0100574)2.50106745
58Type I transferrin isoform profile (HP:0003642)2.48882060
59Squamous cell carcinoma (HP:0002860)2.48824825
60Proximal placement of thumb (HP:0009623)2.45863635
61Increased hepatocellular lipid droplets (HP:0006565)2.44569205
62Neoplasm of striated muscle (HP:0009728)2.43744992
63Premature graying of hair (HP:0002216)2.40514759
64Deviation of the thumb (HP:0009603)2.40441556
65Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.39434797
66Abnormal protein N-linked glycosylation (HP:0012347)2.39434797
67Abnormal protein glycosylation (HP:0012346)2.39434797
68Abnormal glycosylation (HP:0012345)2.39434797
69Prolonged bleeding time (HP:0003010)2.38097031
70Increased serum lactate (HP:0002151)2.37748538
71Thrombocytosis (HP:0001894)2.37556994
72Duodenal stenosis (HP:0100867)2.37161329
73Small intestinal stenosis (HP:0012848)2.37161329
74Supernumerary spleens (HP:0009799)2.33084995
75Absent radius (HP:0003974)2.30325242
76B lymphocytopenia (HP:0010976)2.27469829
77Megaloblastic anemia (HP:0001889)2.26587315
7811 pairs of ribs (HP:0000878)2.26054819
79Pallor (HP:0000980)2.25964992
80Sloping forehead (HP:0000340)2.25928615
81Cafe-au-lait spot (HP:0000957)2.24669097
82Secondary amenorrhea (HP:0000869)2.24250163
83Trismus (HP:0000211)2.24005639
84Severe combined immunodeficiency (HP:0004430)2.21063045
85Bone marrow hypocellularity (HP:0005528)2.19622273
86Acute myeloid leukemia (HP:0004808)2.19134559
87Acute encephalopathy (HP:0006846)2.19079069
88Lipid accumulation in hepatocytes (HP:0006561)2.17761669
89Atrophy/Degeneration involving motor neurons (HP:0007373)2.17366654
90Adenoma sebaceum (HP:0009720)2.16949434
91Angiofibromas (HP:0010615)2.16949434
92Progressive external ophthalmoplegia (HP:0000590)2.16665503
93Neoplasm of the colon (HP:0100273)2.16518354
94Facial hemangioma (HP:0000329)2.16365941
95Neoplasm of the oral cavity (HP:0100649)2.16311064
96Atresia of the external auditory canal (HP:0000413)2.15953859
97Prominent nose (HP:0000448)2.15670504
98Abnormality of serum amino acid levels (HP:0003112)2.14696522
99Horseshoe kidney (HP:0000085)2.14643973
100Cutaneous melanoma (HP:0012056)2.14560338
101Panhypogammaglobulinemia (HP:0003139)2.11887531
102Missing ribs (HP:0000921)2.10689473
103Cellular immunodeficiency (HP:0005374)2.10373069
104IgM deficiency (HP:0002850)2.10028634
105Entropion (HP:0000621)2.08479680
106Aplasia involving forearm bones (HP:0009822)2.07388100
107Absent forearm bone (HP:0003953)2.07388100
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06990582
109Abnormal lung lobation (HP:0002101)2.06409072
110Spastic diplegia (HP:0001264)2.05772734
111Volvulus (HP:0002580)2.05036588
112Acanthocytosis (HP:0001927)2.04805540
113CNS hypomyelination (HP:0003429)2.03111260
114Pelvic girdle muscle weakness (HP:0003749)2.02592251
115Progressive muscle weakness (HP:0003323)2.02351062
116Abnormality of pyrimidine metabolism (HP:0004353)2.01469749
117Abnormality of the duodenum (HP:0002246)2.00518774
118Personality changes (HP:0000751)1.99528071
119Ectopic kidney (HP:0000086)1.98484877
120Petechiae (HP:0000967)1.98182187
121Increased CSF lactate (HP:0002490)1.97367784
122Neoplasm of the rectum (HP:0100743)1.97210675
123Increased nuchal translucency (HP:0010880)1.96029933
124Clubbing of toes (HP:0100760)1.94263464
125Slender long bone (HP:0003100)1.92179895
126Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.90918438
127Sparse lateral eyebrow (HP:0005338)1.90907239
128Erythroderma (HP:0001019)1.90833150
129Abnormal trabecular bone morphology (HP:0100671)1.89931357
130Abnormal hair whorl (HP:0010721)1.89351274
131Tracheoesophageal fistula (HP:0002575)1.89338492
132Abnormality of the pons (HP:0007361)1.89013988
133Lymphoma (HP:0002665)1.88391561
134Poikiloderma (HP:0001029)1.87580736
135Shoulder girdle muscle weakness (HP:0003547)1.87524134
136Abnormality of sulfur amino acid metabolism (HP:0004339)1.86434244
137Cerebral edema (HP:0002181)1.86224894
138Postnatal microcephaly (HP:0005484)1.85664335
139Abnormality of the carotid arteries (HP:0005344)1.85394901
140Hypoplasia of the pons (HP:0012110)1.85075194
141Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84579583
142Pancytopenia (HP:0001876)1.83898623
143Dyschromatopsia (HP:0007641)1.83224897
144Glossoptosis (HP:0000162)1.81888588
145Abnormal number of incisors (HP:0011064)1.81002312
146Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80570042
147Respiratory difficulties (HP:0002880)1.80370782
148Pancreatic islet-cell hyperplasia (HP:0004510)1.80315491
149Freckling (HP:0001480)1.79613318
150Lactic acidosis (HP:0003128)1.78753209
151Ovarian neoplasm (HP:0100615)1.78600273
152Acute necrotizing encephalopathy (HP:0006965)1.76743331
153Abnormality of B cell number (HP:0010975)1.75701004
154Hypoplastic pelvis (HP:0008839)1.74347720
155Autoamputation (HP:0001218)1.73176383
156Embryonal neoplasm (HP:0002898)1.70861150
157Neoplasm of the small intestine (HP:0100833)1.68194683
158Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.67978852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.39038833
2WEE14.35385256
3BUB14.26333976
4PBK3.81370414
5TSSK63.42767961
6EIF2AK13.32616919
7NEK22.73434219
8NEK12.59897386
9MST42.56275848
10SRPK12.54804372
11TTK2.42993267
12BRSK22.39077596
13ACVR1B2.24269006
14VRK22.21950902
15EEF2K2.21418359
16SCYL22.03547543
17PLK11.97257679
18EIF2AK31.86389648
19RPS6KB21.82988753
20NME21.82760948
21PLK31.80348669
22CDK121.78604062
23MAP4K21.75161111
24PASK1.70273216
25ATR1.66390247
26AURKB1.60204970
27MKNK11.60171844
28CDK71.58197767
29TGFBR11.55711085
30PLK41.55048074
31NME11.53366931
32TLK11.52697791
33VRK11.51656304
34RPS6KA41.45153361
35CDK41.44442563
36NUAK11.43177137
37CHEK21.42271787
38MAP3K81.40825249
39BRSK11.40796361
40TRIM281.40007767
41STK101.36834722
42CHEK11.33056305
43EPHA21.24161960
44AURKA1.22933148
45PNCK1.20147914
46ERBB31.19874654
47DYRK31.19328297
48FLT31.16667036
49TESK21.15481936
50TEC1.14857325
51PDK31.12690813
52PDK41.12690813
53STK161.11915631
54ALK1.06242175
55PKN21.06190288
56PAK41.04251402
57MKNK21.02640041
58CCNB10.98041578
59MAP3K100.95360364
60ATM0.94035108
61CDK20.92296860
62LATS20.89402689
63MAP4K10.86685209
64TAF10.84167569
65CSNK2A20.82977454
66PIM10.78050230
67NEK90.75064769
68BRD40.69707301
69ZAK0.69505179
70STK30.67385139
71CLK10.66367656
72CDK80.66021596
73MELK0.64304588
74STK40.64002728
75BCR0.63893592
76TNIK0.63416937
77MAP2K30.63076407
78CDK10.62737147
79CSNK2A10.61740402
80CDK60.61484471
81BCKDK0.60890465
82PAK10.59438369
83GRK60.57158223
84CSNK1E0.57062669
85LRRK20.55742937
86MTOR0.54881241
87SMG10.54754609
88DAPK10.53786742
89ZAP700.51037022
90BRAF0.50768737
91MAP3K120.50768608
92MAP3K110.49008406
93RPS6KA50.48458787
94MAPKAPK30.47936461
95PDK20.44331925
96CDK90.41282117
97TXK0.40434147
98STK38L0.40315723
99PRKCI0.38572595
100PAK20.37457190
101AKT20.37279665
102JAK30.36887363
103FGFR10.36245324
104CSNK1G10.36065225
105MST1R0.34989939
106CSNK1G30.34813865
107ERBB40.34448752
108PRKDC0.34191432
109PLK20.33883004
110CSNK1A1L0.33327806
111RPS6KB10.33303260
112TESK10.31577726
113PIM20.29346743
114KDR0.29158551
115EIF2AK20.28611085
116MAPKAPK50.27852152
117CSF1R0.26708873
118LATS10.26449807
119CSNK1D0.25810005
120WNK30.25518213
121TAOK20.25074169
122RAF10.24985495
123CDK30.24813761
124BMPR1B0.22389360
125MAPK140.22150945
126ITK0.20817403
127SIK30.20358156
128WNK40.20075295
129AKT30.18492326
130ILK0.18240999
131STK240.16096466

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70033108
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.23878461
3Mismatch repair_Homo sapiens_hsa034304.11617197
4RNA transport_Homo sapiens_hsa030133.58989544
5Spliceosome_Homo sapiens_hsa030403.31374262
6One carbon pool by folate_Homo sapiens_hsa006703.31202686
7RNA polymerase_Homo sapiens_hsa030203.16291969
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.04733029
9Proteasome_Homo sapiens_hsa030503.02244592
10Ribosome_Homo sapiens_hsa030102.94353464
11Base excision repair_Homo sapiens_hsa034102.86282078
12Cell cycle_Homo sapiens_hsa041102.75423042
13Nucleotide excision repair_Homo sapiens_hsa034202.71220982
14Homologous recombination_Homo sapiens_hsa034402.56586181
15Pyrimidine metabolism_Homo sapiens_hsa002402.36272291
16RNA degradation_Homo sapiens_hsa030182.05647452
17Fanconi anemia pathway_Homo sapiens_hsa034602.02967093
18Non-homologous end-joining_Homo sapiens_hsa034501.91473006
19mRNA surveillance pathway_Homo sapiens_hsa030151.86682208
20Basal transcription factors_Homo sapiens_hsa030221.81022861
21Propanoate metabolism_Homo sapiens_hsa006401.72602607
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.59535614
23Vitamin B6 metabolism_Homo sapiens_hsa007501.54964158
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.44532063
25p53 signaling pathway_Homo sapiens_hsa041151.43820958
26Biosynthesis of amino acids_Homo sapiens_hsa012301.33380803
27Systemic lupus erythematosus_Homo sapiens_hsa053221.28841083
28Purine metabolism_Homo sapiens_hsa002301.23774460
29Epstein-Barr virus infection_Homo sapiens_hsa051691.22369171
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14055217
31Selenocompound metabolism_Homo sapiens_hsa004501.11028806
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10993772
33Viral carcinogenesis_Homo sapiens_hsa052031.09409234
34Antigen processing and presentation_Homo sapiens_hsa046121.07830368
35Oocyte meiosis_Homo sapiens_hsa041141.05870402
36Fatty acid elongation_Homo sapiens_hsa000621.04405240
37Steroid biosynthesis_Homo sapiens_hsa001001.01560876
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.99166881
39Drug metabolism - other enzymes_Homo sapiens_hsa009830.98813322
40Pentose phosphate pathway_Homo sapiens_hsa000300.93161269
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92793784
42Folate biosynthesis_Homo sapiens_hsa007900.91125752
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89736513
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88894750
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86431030
46Sulfur relay system_Homo sapiens_hsa041220.83957202
47Herpes simplex infection_Homo sapiens_hsa051680.81879818
48Thyroid cancer_Homo sapiens_hsa052160.81834777
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80280810
50Carbon metabolism_Homo sapiens_hsa012000.79410780
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78532113
52Parkinsons disease_Homo sapiens_hsa050120.77552181
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75192899
54HTLV-I infection_Homo sapiens_hsa051660.70468455
55Fatty acid metabolism_Homo sapiens_hsa012120.68765347
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62149233
57Legionellosis_Homo sapiens_hsa051340.61280620
58Sulfur metabolism_Homo sapiens_hsa009200.55739946
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54510818
60Small cell lung cancer_Homo sapiens_hsa052220.54231111
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54070880
62Oxidative phosphorylation_Homo sapiens_hsa001900.53720942
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52511507
64MicroRNAs in cancer_Homo sapiens_hsa052060.50481104
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.50266704
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48882357
67Alcoholism_Homo sapiens_hsa050340.46194644
68Fructose and mannose metabolism_Homo sapiens_hsa000510.41048669
69mTOR signaling pathway_Homo sapiens_hsa041500.39920438
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39482406
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37574288
72Peroxisome_Homo sapiens_hsa041460.37565224
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37485246
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37198851
75Colorectal cancer_Homo sapiens_hsa052100.37176464
76Butanoate metabolism_Homo sapiens_hsa006500.36719240
77Shigellosis_Homo sapiens_hsa051310.36588005
78N-Glycan biosynthesis_Homo sapiens_hsa005100.36370814
79Glutathione metabolism_Homo sapiens_hsa004800.36036184
80Apoptosis_Homo sapiens_hsa042100.33879637
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31393297
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30226836
83Hepatitis B_Homo sapiens_hsa051610.29669602
84Pyruvate metabolism_Homo sapiens_hsa006200.29546411
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26831723
86Chronic myeloid leukemia_Homo sapiens_hsa052200.25921682
87HIF-1 signaling pathway_Homo sapiens_hsa040660.25467915
88Hippo signaling pathway_Homo sapiens_hsa043900.25413348
89Primary immunodeficiency_Homo sapiens_hsa053400.25076375
90TGF-beta signaling pathway_Homo sapiens_hsa043500.24339568
91Galactose metabolism_Homo sapiens_hsa000520.24306287
92Measles_Homo sapiens_hsa051620.23206686
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22614365
94Acute myeloid leukemia_Homo sapiens_hsa052210.21706470
95Bladder cancer_Homo sapiens_hsa052190.19824868
96Adherens junction_Homo sapiens_hsa045200.18675713
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.18647986
98Influenza A_Homo sapiens_hsa051640.17771789
99Hematopoietic cell lineage_Homo sapiens_hsa046400.17192928
100Metabolic pathways_Homo sapiens_hsa011000.16033746
101Huntingtons disease_Homo sapiens_hsa050160.15954156
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15668855
103Platelet activation_Homo sapiens_hsa046110.15249896
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15235321
105Fatty acid degradation_Homo sapiens_hsa000710.14935911
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13830268
107Alzheimers disease_Homo sapiens_hsa050100.13262113
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12950578
109Non-small cell lung cancer_Homo sapiens_hsa052230.12507302
110Arginine and proline metabolism_Homo sapiens_hsa003300.12099822
111Nitrogen metabolism_Homo sapiens_hsa009100.12073039
112Renin-angiotensin system_Homo sapiens_hsa046140.11584267
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.11241622
114Pathways in cancer_Homo sapiens_hsa052000.10892939
115Lysine degradation_Homo sapiens_hsa003100.09683332
116Basal cell carcinoma_Homo sapiens_hsa052170.09605884
117Prostate cancer_Homo sapiens_hsa052150.08949739
118Notch signaling pathway_Homo sapiens_hsa043300.07190889
119Protein export_Homo sapiens_hsa030600.04182789
120Viral myocarditis_Homo sapiens_hsa054160.03632042
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03447628
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02125894
123Regulation of autophagy_Homo sapiens_hsa041400.01632883

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