TTC28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.86238320
2positive regulation of fatty acid beta-oxidation (GO:0032000)4.78649055
3regulation of non-canonical Wnt signaling pathway (GO:2000050)4.45602560
4tooth mineralization (GO:0034505)4.20621972
5otic vesicle formation (GO:0030916)4.20147231
6cell proliferation in forebrain (GO:0021846)4.19206035
7positive regulation of fatty acid oxidation (GO:0046321)4.17111330
8negative regulation of appetite (GO:0032099)4.08323070
9negative regulation of response to food (GO:0032096)4.08323070
10positive regulation of cardiac muscle cell differentiation (GO:2000727)4.02004968
11axon extension involved in axon guidance (GO:0048846)3.89034747
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.89034747
13lymphangiogenesis (GO:0001946)3.85686995
14membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76718356
15positive regulation of action potential (GO:0045760)3.71303394
16negative regulation of transcription regulatory region DNA binding (GO:2000678)3.65745105
17protein heterotrimerization (GO:0070208)3.63854437
18epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.52614633
19serotonin metabolic process (GO:0042428)3.42870142
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.41867913
21negative regulation of catenin import into nucleus (GO:0035414)3.32963229
22insulin-like growth factor receptor signaling pathway (GO:0048009)3.28563827
23presynaptic membrane assembly (GO:0097105)3.26003550
24segment specification (GO:0007379)3.26003443
25retinal ganglion cell axon guidance (GO:0031290)3.25883575
26bone trabecula formation (GO:0060346)3.15836886
27negative regulation of protein localization to cell surface (GO:2000009)3.14496247
28plasma membrane repair (GO:0001778)3.14350950
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.11103169
30type B pancreatic cell development (GO:0003323)3.10788258
31regulation of fatty acid beta-oxidation (GO:0031998)3.10594300
32positive regulation of glycogen biosynthetic process (GO:0045725)3.05873446
33primary amino compound metabolic process (GO:1901160)3.05233737
34presynaptic membrane organization (GO:0097090)3.04851218
35glandular epithelial cell development (GO:0002068)3.04771686
36postsynaptic membrane organization (GO:0001941)3.04744699
37pyrimidine nucleobase catabolic process (GO:0006208)3.04190699
38pharyngeal system development (GO:0060037)3.03610346
39exocrine pancreas development (GO:0031017)3.02686548
40camera-type eye morphogenesis (GO:0048593)2.99881432
41lung secretory cell differentiation (GO:0061140)2.99424025
42cell migration in hindbrain (GO:0021535)2.98710331
43glomerulus development (GO:0032835)2.98690716
44cardiac myofibril assembly (GO:0055003)2.96972874
45regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.96953175
46appendage development (GO:0048736)2.93652794
47limb development (GO:0060173)2.93652794
48collagen fibril organization (GO:0030199)2.90105592
49aorta morphogenesis (GO:0035909)2.89693563
50regulation of action potential (GO:0098900)2.87966656
51regulation of axon extension involved in axon guidance (GO:0048841)2.86520607
52artery development (GO:0060840)2.85213411
53epithelial cell fate commitment (GO:0072148)2.83625558
54regulation of axon guidance (GO:1902667)2.82687060
55smooth muscle tissue development (GO:0048745)2.81324517
56central nervous system projection neuron axonogenesis (GO:0021952)2.80790867
57ganglion development (GO:0061548)2.80765257
58regulation of transcription regulatory region DNA binding (GO:2000677)2.80299465
59regulation of sequestering of triglyceride (GO:0010889)2.79294399
60indolalkylamine metabolic process (GO:0006586)2.78613500
61metanephric mesenchyme development (GO:0072075)2.77941164
62axon extension (GO:0048675)2.77723815
63chondrocyte proliferation (GO:0035988)2.75393309
64regulation of membrane repolarization (GO:0060306)2.74524088
65astrocyte differentiation (GO:0048708)2.74082626
66positive regulation of hormone biosynthetic process (GO:0046886)2.74043418
67vascular endothelial growth factor signaling pathway (GO:0038084)2.73605929
68layer formation in cerebral cortex (GO:0021819)2.73111056
69proximal/distal pattern formation (GO:0009954)2.69465408
70hippo signaling (GO:0035329)2.68826212
71kidney mesenchyme development (GO:0072074)2.67151025
72axonal fasciculation (GO:0007413)2.66365093
73convergent extension (GO:0060026)2.65109692
74positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.64893924
75regulation of response to food (GO:0032095)2.64331505
76protein polyglutamylation (GO:0018095)2.62277538
77forebrain morphogenesis (GO:0048853)2.61474039
78dendrite morphogenesis (GO:0048813)2.60469928
79head development (GO:0060322)2.59317570
80sequestering of extracellular ligand from receptor (GO:0035581)2.58816802
81negative regulation of systemic arterial blood pressure (GO:0003085)2.58497792
82embryonic hindlimb morphogenesis (GO:0035116)2.56554931
83regulation of cardiac muscle cell differentiation (GO:2000725)2.56362347
84negative regulation of chondrocyte differentiation (GO:0032331)2.55601009
85negative regulation of cartilage development (GO:0061037)2.52807520
86negative regulation of axon guidance (GO:1902668)2.52250721
87negative regulation of axon extension involved in axon guidance (GO:0048843)2.51876334
88positive regulation of glycogen metabolic process (GO:0070875)2.50824401
89positive regulation of gastrulation (GO:2000543)2.50758112
90cell migration involved in heart development (GO:0060973)2.50648900
91COPI coating of Golgi vesicle (GO:0048205)2.50198285
92Golgi transport vesicle coating (GO:0048200)2.50198285
93heart morphogenesis (GO:0003007)2.49710108
94negative regulation of cardiac muscle tissue development (GO:0055026)2.49535672
95somite development (GO:0061053)2.49062857
96body morphogenesis (GO:0010171)2.48846215
97hindlimb morphogenesis (GO:0035137)2.48211795
98kidney morphogenesis (GO:0060993)2.46365512
99growth hormone secretion (GO:0030252)2.46233396
100atrial septum morphogenesis (GO:0060413)2.45814748
101cell migration involved in sprouting angiogenesis (GO:0002042)2.44632631
102branching involved in salivary gland morphogenesis (GO:0060445)2.44024056
103regulation of appetite (GO:0032098)2.43696758
104gamma-aminobutyric acid transport (GO:0015812)2.43180505
105transmission of nerve impulse (GO:0019226)2.42520737
106dopaminergic neuron differentiation (GO:0071542)2.42431097
107dendritic spine morphogenesis (GO:0060997)2.42425806
108mesonephros development (GO:0001823)2.41297882
109regulation of hippo signaling (GO:0035330)2.40185477
110cerebellar Purkinje cell layer development (GO:0021680)2.40084571
111negative regulation of fatty acid transport (GO:2000192)2.39874045
112water-soluble vitamin biosynthetic process (GO:0042364)2.39449281
113epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.39317865
114retina vasculature morphogenesis in camera-type eye (GO:0061299)2.37988096
115cochlea morphogenesis (GO:0090103)2.37887846
116regulation of neuron migration (GO:2001222)2.37863944
117lateral sprouting from an epithelium (GO:0060601)2.37431817
118lymph vessel development (GO:0001945)2.37153870
119nonmotile primary cilium assembly (GO:0035058)2.36480519
120semaphorin-plexin signaling pathway (GO:0071526)2.36247745
121negative regulation of astrocyte differentiation (GO:0048712)2.35952338
122auditory behavior (GO:0031223)2.35806997
123neuronal action potential (GO:0019228)2.34676601
124neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.34398686
125spinal cord development (GO:0021510)2.34316461
126venous blood vessel morphogenesis (GO:0048845)2.34147291
127coronary vasculature morphogenesis (GO:0060977)2.32964672
128dorsal/ventral axis specification (GO:0009950)2.32847661
129negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.32395303
130regulation of mesoderm development (GO:2000380)2.32170396
131chondrocyte development (GO:0002063)2.31613481
132cell migration involved in gastrulation (GO:0042074)2.30619640
133dorsal/ventral pattern formation (GO:0009953)2.30306922
134neuronal stem cell maintenance (GO:0097150)2.29931257
135glial cell proliferation (GO:0014009)2.29808041
136collecting duct development (GO:0072044)2.29596037
137positive regulation of sodium ion transmembrane transport (GO:1902307)2.29426060
138negative chemotaxis (GO:0050919)2.29386542
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.29331408
140regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29186397
141limb bud formation (GO:0060174)2.29054890
142polarized epithelial cell differentiation (GO:0030859)2.29048861
143cardiac ventricle formation (GO:0003211)2.28863644
144cerebral cortex radially oriented cell migration (GO:0021799)2.28724386
145gastrulation with mouth forming second (GO:0001702)2.28331770
146cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.28292496
147positive regulation of axon extension (GO:0045773)2.27593811
148myofibril assembly (GO:0030239)2.26649946
149neuron recognition (GO:0008038)2.26644088
150response to misfolded protein (GO:0051788)2.26562849
151membrane depolarization during action potential (GO:0086010)2.26311254
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.25638670
153metanephros development (GO:0001656)2.25545143
154organ induction (GO:0001759)2.24458367
155regulation of establishment of planar polarity (GO:0090175)2.24273662
156regulation of fatty acid oxidation (GO:0046320)2.23793738
157eye morphogenesis (GO:0048592)2.23609629
158ovulation cycle (GO:0042698)2.23557959
159regulation of organ formation (GO:0003156)2.23486514
160neuron projection extension (GO:1990138)2.22984739
161embryonic body morphogenesis (GO:0010172)2.22640810
162cardiovascular system development (GO:0072358)2.22490221
163indole-containing compound metabolic process (GO:0042430)2.21782964
164cytoplasmic mRNA processing body assembly (GO:0033962)2.20747370
165cardiac muscle cell proliferation (GO:0060038)2.20637252
166cardiac chamber formation (GO:0003207)2.20499094
167negative regulation of oligodendrocyte differentiation (GO:0048715)2.20234842
168outer ear morphogenesis (GO:0042473)2.19702075
169non-canonical Wnt signaling pathway (GO:0035567)2.18787760
170glomerular basement membrane development (GO:0032836)2.18387525
171endocardial cushion morphogenesis (GO:0003203)2.17828337
172regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.17398481
173mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.15971060
174negative regulation of cell size (GO:0045792)2.15663323
175nucleobase catabolic process (GO:0046113)2.14764173
176facial nerve structural organization (GO:0021612)2.13167869
177hindbrain development (GO:0030902)2.12233171
178central nervous system neuron axonogenesis (GO:0021955)2.12149183
179regulation of mesenchymal cell proliferation (GO:0010464)2.11838679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.71806172
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.89916910
3* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.60579454
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.59838264
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.59585507
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.54871478
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.51142325
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44110149
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44110149
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39643284
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36586664
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.33932483
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23344809
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23311845
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19836074
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19601188
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.13214481
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10734602
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08454858
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06554137
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04618162
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.02868829
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95058846
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.93583095
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.92067029
26DROSHA_22980978_ChIP-Seq_HELA_Human1.91852433
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91001853
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.89965950
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.79852003
30RNF2_27304074_Chip-Seq_NSC_Mouse1.78601665
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.77076028
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76768596
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76543879
34* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.76216668
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74302739
36ISL1_27105846_Chip-Seq_CPCs_Mouse1.73703307
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73337939
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72894630
39RING1B_27294783_Chip-Seq_NPCs_Mouse1.71082628
40GBX2_23144817_ChIP-Seq_PC3_Human1.70123939
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.68114695
42* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66497414
43KDM2B_26808549_Chip-Seq_K562_Human1.65578814
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63563206
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.63132396
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62668850
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61389355
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.59778461
49FUS_26573619_Chip-Seq_HEK293_Human1.59417254
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.58797415
51VDR_22108803_ChIP-Seq_LS180_Human1.58664393
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56927313
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56549944
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.56319153
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55832545
56P300_19829295_ChIP-Seq_ESCs_Human1.55774800
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55681529
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55180760
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55180760
60TAF15_26573619_Chip-Seq_HEK293_Human1.54537883
61IGF1R_20145208_ChIP-Seq_DFB_Human1.54421720
62EWS_26573619_Chip-Seq_HEK293_Human1.54418586
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53702926
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53458419
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51173362
66* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50198939
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.50068026
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47318747
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46709482
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44759236
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43818405
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38930202
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35537878
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.33389071
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33171667
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31917023
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31612957
78CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31131742
79TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29613428
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28098428
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27815744
82* KDM2B_26808549_Chip-Seq_JURKAT_Human1.26994367
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25803493
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25153346
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24032585
86* STAT3_23295773_ChIP-Seq_U87_Human1.23617902
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23363009
88AHR_22903824_ChIP-Seq_MCF-7_Human1.23303729
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21147417
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21087010
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.20037243
92ZNF274_21170338_ChIP-Seq_K562_Hela1.19617643
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19380655
94* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19147932
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19139290
96* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19108417
97IRF1_19129219_ChIP-ChIP_H3396_Human1.18037425
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.16938676
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16839837
100CLOCK_20551151_ChIP-Seq_293T_Human1.16387332
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15483706
102* TCF4_23295773_ChIP-Seq_U87_Human1.15329742
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15303520
104KDM2B_26808549_Chip-Seq_DND41_Human1.15020923
105AR_25329375_ChIP-Seq_VCAP_Human1.13697500
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12506463
107NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11700792
108BRD4_25478319_ChIP-Seq_HGPS_Human1.11229426
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10203721
110AR_19668381_ChIP-Seq_PC3_Human1.09928904
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09167813
112P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08063428
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07996382
114TP53_18474530_ChIP-ChIP_U2OS_Human1.07904688
115TBX20_22328084_ChIP-Seq_HEART_Mouse1.07360812
116TBX20_22080862_ChIP-Seq_HEART_Mouse1.07360812
117SOX9_26525672_Chip-Seq_HEART_Mouse1.05886799
118* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05825961
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05444784
120AR_21572438_ChIP-Seq_LNCaP_Human1.05096131
121SALL1_21062744_ChIP-ChIP_HESCs_Human1.03528711
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03059587
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.03045803
124TCF4_18268006_ChIP-ChIP_LS174T_Human1.02778976
125CJUN_26792858_Chip-Seq_BT549_Human1.01593617
126CBP_20019798_ChIP-Seq_JUKART_Human1.01524768
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01524768
128* SMAD4_21741376_ChIP-Seq_HESCs_Human1.00640734
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00064923
130SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99024859
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98655412
132REST_18959480_ChIP-ChIP_MESCs_Mouse0.98581753
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.98102472
134KDM2B_26808549_Chip-Seq_REH_Human0.97767084
135EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97232450
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96586057
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95980764
138MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.95701159
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94227092
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.94206402
141CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93132642
142REST_21632747_ChIP-Seq_MESCs_Mouse0.92545889
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92185178
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92118194
145TBX3_20139965_ChIP-Seq_ESCs_Mouse0.91480363
146SMAD_19615063_ChIP-ChIP_OVARY_Human0.89711294
147CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88490085
148* TP53_23651856_ChIP-Seq_MEFs_Mouse0.88100400
149SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87222963
150SMAD4_21799915_ChIP-Seq_A2780_Human0.86583534
151BCAT_22108803_ChIP-Seq_LS180_Human0.86057142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.80965005
2MP0006292_abnormal_olfactory_placode2.83737943
3MP0005503_abnormal_tendon_morphology2.83140599
4MP0009780_abnormal_chondrocyte_physiolo2.81273098
5MP0003283_abnormal_digestive_organ2.51687583
6MP0003646_muscle_fatigue2.22458225
7MP0005257_abnormal_intraocular_pressure2.21445803
8MP0002837_dystrophic_cardiac_calcinosis2.19561744
9MP0003122_maternal_imprinting2.17269266
10MP0005275_abnormal_skin_tensile2.15346822
11MP0003385_abnormal_body_wall2.07487042
12MP0004272_abnormal_basement_membrane2.07096087
13MP0002160_abnormal_reproductive_system2.04301520
14MP0002102_abnormal_ear_morphology1.98940692
15MP0010030_abnormal_orbit_morphology1.98940095
16MP0004130_abnormal_muscle_cell1.96489669
17MP0003705_abnormal_hypodermis_morpholog1.95494343
18MP0003279_aneurysm1.95199370
19MP0000049_abnormal_middle_ear1.91233144
20MP0010368_abnormal_lymphatic_system1.90496070
21MP0005623_abnormal_meninges_morphology1.88340448
22MP0004885_abnormal_endolymph1.86414676
23MP0003942_abnormal_urinary_system1.74577234
24MP0002896_abnormal_bone_mineralization1.71714128
25MP0004215_abnormal_myocardial_fiber1.70837940
26MP0000751_myopathy1.69793227
27MP0001879_abnormal_lymphatic_vessel1.69760185
28MP0005646_abnormal_pituitary_gland1.68617323
29MP0008775_abnormal_heart_ventricle1.67971986
30MP0004133_heterotaxia1.66817594
31MP0003938_abnormal_ear_development1.63370984
32MP0005508_abnormal_skeleton_morphology1.61878681
33MP0009250_abnormal_appendicular_skeleto1.61783360
34MP0000778_abnormal_nervous_system1.59653445
35MP0001299_abnormal_eye_distance/1.59058205
36MP0000013_abnormal_adipose_tissue1.57982971
37MP0002877_abnormal_melanocyte_morpholog1.57907555
38MP0000428_abnormal_craniofacial_morphol1.54631003
39MP0003880_abnormal_central_pattern1.53698860
40MP0003935_abnormal_craniofacial_develop1.53201560
41MP0000537_abnormal_urethra_morphology1.52645759
42MP0005248_abnormal_Harderian_gland1.51293296
43MP0002249_abnormal_larynx_morphology1.51204697
44MP0002108_abnormal_muscle_morphology1.50768381
45MP0000534_abnormal_ureter_morphology1.50421035
46MP0001958_emphysema1.48666221
47MP0002116_abnormal_craniofacial_bone1.47442322
48MP0002234_abnormal_pharynx_morphology1.47165234
49MP0003136_yellow_coat_color1.44792906
50MP0003011_delayed_dark_adaptation1.42109635
51MP0000733_abnormal_muscle_development1.41651742
52MP0002909_abnormal_adrenal_gland1.40669920
53MP0003115_abnormal_respiratory_system1.40464922
54MP0003755_abnormal_palate_morphology1.39593036
55MP0001968_abnormal_touch/_nociception1.39163957
56MP0003890_abnormal_embryonic-extraembry1.38384907
57MP0001293_anophthalmia1.37490120
58MP0003567_abnormal_fetal_cardiomyocyte1.36706958
59MP0000569_abnormal_digit_pigmentation1.36487105
60MP0003119_abnormal_digestive_system1.35414303
61MP0005076_abnormal_cell_differentiation1.33126793
62MP0002736_abnormal_nociception_after1.30822922
63MP0004145_abnormal_muscle_electrophysio1.28990337
64MP0002272_abnormal_nervous_system1.27703235
65MP0000026_abnormal_inner_ear1.26297425
66MP0006072_abnormal_retinal_apoptosis1.25963609
67MP0000678_abnormal_parathyroid_gland1.25506193
68MP0006276_abnormal_autonomic_nervous1.25106107
69MP0000003_abnormal_adipose_tissue1.24968403
70MP0002938_white_spotting1.24505787
71MP0005551_abnormal_eye_electrophysiolog1.24356597
72MP0008961_abnormal_basal_metabolism1.21901554
73MP0002638_abnormal_pupillary_reflex1.20424435
74MP0009053_abnormal_anal_canal1.19951374
75MP0005670_abnormal_white_adipose1.19551590
76MP0004084_abnormal_cardiac_muscle1.18804303
77MP0005187_abnormal_penis_morphology1.18583842
78MP0002932_abnormal_joint_morphology1.18347545
79MP0001944_abnormal_pancreas_morphology1.16994247
80MP0004134_abnormal_chest_morphology1.15104337
81MP0001270_distended_abdomen1.14601569
82MP0005389_reproductive_system_phenotype1.14464491
83MP0002177_abnormal_outer_ear1.13020232
84MP0002233_abnormal_nose_morphology1.12647632
85MP0000955_abnormal_spinal_cord1.12310021
86MP0003635_abnormal_synaptic_transmissio1.11755197
87MP0000163_abnormal_cartilage_morphology1.11165040
88MP0008789_abnormal_olfactory_epithelium1.10533435
89MP0004142_abnormal_muscle_tone1.10323267
90MP0004858_abnormal_nervous_system1.09726339
91MP0006054_spinal_hemorrhage1.09674868
92MP0002735_abnormal_chemical_nociception1.08433824
93MP0003937_abnormal_limbs/digits/tail_de1.07243632
94MP0002734_abnormal_mechanical_nocicepti1.07189565
95MP0002557_abnormal_social/conspecific_i1.05365660
96MP0002063_abnormal_learning/memory/cond1.05161321
97MP0002733_abnormal_thermal_nociception1.04566984
98MP0001486_abnormal_startle_reflex1.04490950
99MP0002752_abnormal_somatic_nervous1.03923974
100MP0002572_abnormal_emotion/affect_behav1.03559989
101MP0000767_abnormal_smooth_muscle1.01878309
102MP0000566_synostosis1.00551584
103MP0009745_abnormal_behavioral_response1.00283379
104MP0005367_renal/urinary_system_phenotyp0.99538998
105MP0000516_abnormal_urinary_system0.99538998
106MP0004233_abnormal_muscle_weight0.99163536
107MP0009046_muscle_twitch0.98895760
108MP0002653_abnormal_ependyma_morphology0.98832069
109MP0005253_abnormal_eye_physiology0.98600163
110MP0001485_abnormal_pinna_reflex0.97362840
111MP0005375_adipose_tissue_phenotype0.97206863
112MP0000759_abnormal_skeletal_muscle0.97080839
113MP0009384_cardiac_valve_regurgitation0.95083888
114MP0000432_abnormal_head_morphology0.95036365
115MP0001970_abnormal_pain_threshold0.94302217
116MP0000631_abnormal_neuroendocrine_gland0.94022422
117MP0004087_abnormal_muscle_fiber0.93220015
118MP0003121_genomic_imprinting0.92526118
119MP0002925_abnormal_cardiovascular_devel0.91758380
120MP0002697_abnormal_eye_size0.91461801
121MP0000750_abnormal_muscle_regeneration0.90913207
122MP0009379_abnormal_foot_pigmentation0.90043731
123MP0000462_abnormal_digestive_system0.90028142
124MP0003045_fibrosis0.89876136
125MP0006138_congestive_heart_failure0.89538984
126MP0003137_abnormal_impulse_conducting0.89148681
127MP0003861_abnormal_nervous_system0.88923173
128MP0003941_abnormal_skin_development0.88626874
129MP0002089_abnormal_postnatal_growth/wei0.87791771
130MP0004859_abnormal_synaptic_plasticity0.87662586
131MP0002064_seizures0.87468752
132MP0001286_abnormal_eye_development0.87454758
133MP0002882_abnormal_neuron_morphology0.87054593
134MP0002127_abnormal_cardiovascular_syste0.87022340
135MP0005195_abnormal_posterior_eye0.86838810
136MP0004085_abnormal_heartbeat0.86218071
137MP0000230_abnormal_systemic_arterial0.85945105
138MP0002152_abnormal_brain_morphology0.85775052
139MP0002822_catalepsy0.85550523
140MP0002751_abnormal_autonomic_nervous0.85200845
141MP0005423_abnormal_somatic_nervous0.84590624
142MP0002109_abnormal_limb_morphology0.84119906
143MP0002114_abnormal_axial_skeleton0.83755313
144MP0002067_abnormal_sensory_capabilities0.83433191
145MP0002115_abnormal_skeleton_extremities0.82885508
146MP0004924_abnormal_behavior0.82624500
147MP0005386_behavior/neurological_phenoty0.82624500
148MP0005220_abnormal_exocrine_pancreas0.81902852
149MP0002081_perinatal_lethality0.81888863
150MP0010630_abnormal_cardiac_muscle0.81760414
151MP0005394_taste/olfaction_phenotype0.81723659
152MP0005499_abnormal_olfactory_system0.81723659
153MP0002184_abnormal_innervation0.80948533
154MP0002282_abnormal_trachea_morphology0.80454795
155MP0005620_abnormal_muscle_contractility0.80262704
156MP0005369_muscle_phenotype0.79496617

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)4.42867830
2Protrusio acetabuli (HP:0003179)4.31839933
3Premature rupture of membranes (HP:0001788)3.64791437
4Short 4th metacarpal (HP:0010044)3.56628204
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.56628204
6Cerebral aneurysm (HP:0004944)3.49408991
7Abnormality of the phalanges of the 2nd finger (HP:0009541)3.30720151
8Hepatoblastoma (HP:0002884)3.29108029
9Broad metatarsal (HP:0001783)3.21398177
10Bladder diverticulum (HP:0000015)3.10087256
11Pancreatic cysts (HP:0001737)3.07877918
12Mesomelia (HP:0003027)2.96246901
13Abnormality of the 4th metacarpal (HP:0010012)2.89388619
14Nephronophthisis (HP:0000090)2.88074010
15Aplasia/Hypoplasia of the tibia (HP:0005772)2.87832466
16Overgrowth (HP:0001548)2.83531110
17Wrist flexion contracture (HP:0001239)2.79914693
18Pancreatic fibrosis (HP:0100732)2.76853528
19Renal duplication (HP:0000075)2.75678472
20Aortic dissection (HP:0002647)2.74492674
21Short tibia (HP:0005736)2.73025804
22Aortic aneurysm (HP:0004942)2.64183238
23Ankle contracture (HP:0006466)2.63612304
24Fibular hypoplasia (HP:0003038)2.63491435
25Aplasia/Hypoplasia of the fibula (HP:0006492)2.62639589
26True hermaphroditism (HP:0010459)2.54575287
27Keratoconus (HP:0000563)2.54043259
28Increased corneal curvature (HP:0100692)2.54043259
29Mildly elevated creatine phosphokinase (HP:0008180)2.45912774
30Abnormality of the renal medulla (HP:0100957)2.44724278
31Hyperventilation (HP:0002883)2.43798441
32Pendular nystagmus (HP:0012043)2.43373128
33Macroorchidism (HP:0000053)2.42535166
34Hyperacusis (HP:0010780)2.41141169
35Cutaneous syndactyly (HP:0012725)2.40773965
36Soft skin (HP:0000977)2.39930678
37Bowel diverticulosis (HP:0005222)2.39001363
38Morphological abnormality of the middle ear (HP:0008609)2.34526000
39Abnormality of the middle phalanges of the toes (HP:0010183)2.34402318
40Short femoral neck (HP:0100864)2.34256304
41Mitral valve prolapse (HP:0001634)2.33560250
42Type 1 muscle fiber predominance (HP:0003803)2.32692977
43Aplasia/Hypoplasia of the patella (HP:0006498)2.31090366
44Progressive cerebellar ataxia (HP:0002073)2.29197922
45Spinal rigidity (HP:0003306)2.27078917
46Hypoplasia of the ulna (HP:0003022)2.25876479
47Abnormality of the proximal phalanges of the hand (HP:0009834)2.25241029
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24204869
49Broad ribs (HP:0000885)2.23701404
50Congenital glaucoma (HP:0001087)2.23611091
51Patellar aplasia (HP:0006443)2.23134706
52Buphthalmos (HP:0000557)2.22595072
53Molar tooth sign on MRI (HP:0002419)2.22378673
54Abnormality of midbrain morphology (HP:0002418)2.22378673
55Fibular aplasia (HP:0002990)2.21984346
56Dilatation of the ascending aorta (HP:0005111)2.21364993
57Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.20588498
58Type II lissencephaly (HP:0007260)2.18175508
59Chorioretinal atrophy (HP:0000533)2.17433993
60Symphalangism affecting the phalanges of the hand (HP:0009773)2.16308586
61Lymphangioma (HP:0100764)2.15823955
62Synostosis of carpal bones (HP:0005048)2.15600867
63Elfin facies (HP:0004428)2.15178686
64Hyperextensible skin (HP:0000974)2.14850740
65Ectopic kidney (HP:0000086)2.14575812
66Flat cornea (HP:0007720)2.14257154
67Genetic anticipation (HP:0003743)2.14047587
68Aneurysm (HP:0002617)2.09723449
69Congenital stationary night blindness (HP:0007642)2.08482821
70Abnormality of the phalanges of the 5th finger (HP:0004213)2.08451515
71Small hand (HP:0200055)2.08450008
72Obstructive sleep apnea (HP:0002870)2.06668238
73Wide anterior fontanel (HP:0000260)2.05712246
74Atrophic scars (HP:0001075)2.05247226
75Abnormality of the 2nd finger (HP:0004100)2.04289802
76Vitreoretinal degeneration (HP:0000655)2.03491656
77Genu recurvatum (HP:0002816)2.02768364
78Midline defect of the nose (HP:0004122)2.02081108
79Deviation of the hallux (HP:0010051)2.01395422
80Germ cell neoplasia (HP:0100728)2.00412064
81Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.99867455
82Pachygyria (HP:0001302)1.99290352
83Increased variability in muscle fiber diameter (HP:0003557)1.98987358
84Aplasia involving bones of the upper limbs (HP:0009823)1.98845996
85Aplasia of the phalanges of the hand (HP:0009802)1.98845996
86Aplasia involving bones of the extremities (HP:0009825)1.98845996
87Cystic liver disease (HP:0006706)1.98800817
88Asymmetry of the thorax (HP:0001555)1.98717144
89Rectal prolapse (HP:0002035)1.98660713
90Neonatal short-limb short stature (HP:0008921)1.98559865
91Renovascular hypertension (HP:0100817)1.98117087
92Aplasia/Hypoplasia of the ulna (HP:0006495)1.97750163
93Short hallux (HP:0010109)1.96733776
94Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.96355051
95Joint laxity (HP:0001388)1.95917417
96Hallux valgus (HP:0001822)1.95119369
97Bilateral microphthalmos (HP:0007633)1.92300968
98Aplasia/Hypoplasia of the hallux (HP:0008362)1.92043893
99Megalencephaly (HP:0001355)1.91647037
100Shawl scrotum (HP:0000049)1.90423909
101Optic nerve hypoplasia (HP:0000609)1.90200958
102Septo-optic dysplasia (HP:0100842)1.90188506
103Radial bowing (HP:0002986)1.89791579
104Broad hallux (HP:0010055)1.89176463
105Abnormality of the nasal septum (HP:0000419)1.88936092
106Exostoses (HP:0100777)1.88809815
107Anophthalmia (HP:0000528)1.88103014
108Bulbous nose (HP:0000414)1.87040120
109Insulin-resistant diabetes mellitus (HP:0000831)1.86967904
110Increased connective tissue (HP:0009025)1.86623866
111Chronic hepatic failure (HP:0100626)1.85769085
112Mesangial abnormality (HP:0001966)1.84615466
113Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.83428315
114Fragile skin (HP:0001030)1.82825323
115Cutaneous finger syndactyly (HP:0010554)1.79454636
116Renal dysplasia (HP:0000110)1.78892654
117Disproportionate tall stature (HP:0001519)1.78570685
118Neoplasm of the heart (HP:0100544)1.77662742
119Exotropia (HP:0000577)1.77358712
120Bronchomalacia (HP:0002780)1.77054656
121Blue sclerae (HP:0000592)1.76910155
122Vascular tortuosity (HP:0004948)1.76339465
123Decreased central vision (HP:0007663)1.75819793
124Anencephaly (HP:0002323)1.75819035
125Abnormal number of incisors (HP:0011064)1.75762887
126Coronal craniosynostosis (HP:0004440)1.75568647
127Medial flaring of the eyebrow (HP:0010747)1.75347539
128Preaxial foot polydactyly (HP:0001841)1.74850656
129Decreased circulating renin level (HP:0003351)1.74676177
130Hypoventilation (HP:0002791)1.74495276
131Camptodactyly of toe (HP:0001836)1.74270999
132Enlarged kidneys (HP:0000105)1.74015969
133Long nose (HP:0003189)1.73944304
134Difficulty running (HP:0009046)1.73288081
135Abnormality of the renal cortex (HP:0011035)1.72895967
136Hypoplastic ischia (HP:0003175)1.72443814
137Hyperinsulinemic hypoglycemia (HP:0000825)1.71849496
138Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.71704848
139Arterial tortuosity (HP:0005116)1.71526675
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70793218
141Oligodontia (HP:0000677)1.70753899
142Rib fusion (HP:0000902)1.70542598
143Abnormality of the incisor (HP:0000676)1.69805606
144Subacute progressive viral hepatitis (HP:0006572)1.68466185
145Follicular hyperkeratosis (HP:0007502)1.68084606
146Abnormality of the fibula (HP:0002991)1.68033973
147Adactyly (HP:0009776)1.67907543
148Cervical subluxation (HP:0003308)1.67782261
149Genital tract atresia (HP:0001827)1.67448944
150Postaxial foot polydactyly (HP:0001830)1.66707164
151Narrow nasal bridge (HP:0000446)1.66368170
152Abnormality of the aortic arch (HP:0012303)1.66137497
153Turricephaly (HP:0000262)1.65680279
154Vaginal atresia (HP:0000148)1.65478984
155Partial duplication of the phalanx of hand (HP:0009999)1.65198248
156Thin bony cortex (HP:0002753)1.64456567
157Short 1st metacarpal (HP:0010034)1.64306318
158Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.64306318
159Narrow palate (HP:0000189)1.64211208
160Choanal stenosis (HP:0000452)1.63984113
161Tibial bowing (HP:0002982)1.63491933
162Drooling (HP:0002307)1.63407902
163Postaxial hand polydactyly (HP:0001162)1.62409959
164Short foot (HP:0001773)1.62331027
165Sclerocornea (HP:0000647)1.61867605
166Broad-based gait (HP:0002136)1.61795954
167Wide cranial sutures (HP:0010537)1.61255985
168Broad toe (HP:0001837)1.61001038
169Abnormality of skeletal muscle fiber size (HP:0012084)1.60588584
170Enlarged penis (HP:0000040)1.60105900
171Broad long bones (HP:0005622)1.59915402
172Abnormality of the pubic bones (HP:0003172)1.58850966
173Agitation (HP:0000713)1.58642394
174Wormian bones (HP:0002645)1.58346656
175Abnormality of the right ventricle (HP:0001707)1.57790809
176Abnormality of dentin (HP:0010299)1.57287518
177Large for gestational age (HP:0001520)1.57113202
178Overriding aorta (HP:0002623)1.56978726
179Venous insufficiency (HP:0005293)1.56737467
180Laryngomalacia (HP:0001601)1.56635130
181Striae distensae (HP:0001065)1.56623122
182Aplasia/Hypoplasia of the sternum (HP:0006714)1.55919692
183Trigonocephaly (HP:0000243)1.55886135
184Arnold-Chiari malformation (HP:0002308)1.55309177
185Insomnia (HP:0100785)1.54209118
186Advanced eruption of teeth (HP:0006288)1.53821063
187Broad thumb (HP:0011304)1.53640192
188Hyperglycemia (HP:0003074)1.53582008
189Increased density of long bones (HP:0006392)1.52586386
190Abnormality of the ischium (HP:0003174)1.52359923
191Sudden death (HP:0001699)1.51868755

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.14380033
2MARK14.07063372
3FRK3.36947740
4TRIB33.33069803
5EPHB23.00857506
6PDGFRA2.97900107
7INSRR2.73146004
8CAMK1G2.47934520
9MAP3K102.00102947
10LATS11.93532998
11PINK11.92993885
12PRKD31.91306798
13DDR21.91121393
14TGFBR21.89880750
15TTN1.87197837
16CAMK1D1.86531697
17WNK31.86373745
18GRK11.85538181
19PASK1.81026011
20SGK21.80431748
21RIPK11.78889158
22BMPR1B1.77103313
23TNIK1.69094639
24PHKG21.69009447
25PHKG11.69009447
26SGK4941.66329500
27SGK2231.66329500
28DMPK1.62877831
29EPHA31.61526353
30SIK11.60253703
31ICK1.56100417
32ERBB31.54991835
33DYRK21.53339309
34WNK41.51644712
35PKN21.50938454
36HIPK21.50117227
37MAPK151.49974125
38ADRBK21.47556202
39NUAK11.44365398
40SIK21.43861396
41PTK61.42329728
42EPHA41.39755760
43CDC42BPA1.36292298
44MAP4K21.34341011
45MAPK131.28290765
46MARK21.24886155
47CDK121.24004589
48LATS21.21776661
49PAK31.17133850
50MTOR1.16223410
51UHMK11.13501499
52PTK21.11700116
53DYRK1B1.11683563
54PDGFRB1.09620276
55PRKD21.09555272
56FER1.09180898
57TIE11.06055573
58PRKCH1.05375703
59FGFR31.04631590
60FGFR21.00129003
61OBSCN0.99864914
62AKT30.99326326
63PAK20.99150264
64NTRK20.98728371
65PRKCG0.93860046
66ZAK0.92095280
67NEK20.91931042
68BCKDK0.91255749
69CSNK1A1L0.88583104
70ROCK10.88496877
71RPS6KA20.87625031
72FGFR10.86947336
73PRKD10.84390188
74TYRO30.83531692
75STK390.81808626
76MAP2K40.78352822
77MAP2K70.77139199
78ERN10.76053257
79PLK20.73392043
80RET0.71950757
81MKNK20.71430925
82TGFBR10.70937683
83BRD40.69489333
84CAMK40.68651759
85PRKAA10.67384598
86EEF2K0.67292020
87ACVR1B0.66259016
88RPS6KA60.65156831
89ABL20.63766502
90CDK90.63603152
91STK30.62314450
92MAPK40.59522668
93PIK3CA0.58932187
94MAPK90.58135819
95STK38L0.57698851
96WNK10.57614121
97ILK0.56753351
98CSNK1G10.56629156
99SGK10.55919601
100PNCK0.55573500
101ERBB20.55485145
102CAMK10.55461187
103PRKACA0.55354061
104GSK3A0.55306675
105LMTK20.54951783
106STK110.54944251
107MAP3K90.54894217
108ADRBK10.54206740
109PAK60.53497758
110MYLK0.52723132
111CAMK2A0.51337008
112CAMKK10.50595554
113CSNK1G20.49172462
114DYRK30.49012494
115KSR10.48566223
116MAP3K40.47867273
117STK160.46601642
118CSNK1G30.44634856
119CDK80.44634542
120PRKCE0.44280576
121DYRK1A0.43389960
122MAPKAPK50.42959852
123CDK50.41521900
124NTRK10.40909198
125PRKG10.40563136
126PRKCZ0.40524786
127NTRK30.40190955
128MINK10.39917996
129WEE10.39439743
130SGK30.39142205
131CASK0.38588037
132MAPK80.38476114
133PKN10.38307699
134PRKACG0.37867207
135AKT10.37795501
136TAOK10.37659234
137IGF1R0.37449556
138MAPK70.37418404
139FLT30.37277131
140INSR0.37195258
141CSNK1A10.36404202
142PAK40.35758059
143RPS6KA30.35720522
144CSNK1E0.35713199
145RPS6KC10.35648010
146RPS6KL10.35648010
147AURKA0.35588188
148CHEK20.35253508
149MAP3K70.34316021
150PRKAA20.34051060

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.75047701
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.52503254
3Phototransduction_Homo sapiens_hsa047442.13497708
4Basal cell carcinoma_Homo sapiens_hsa052172.10236612
5Axon guidance_Homo sapiens_hsa043601.90661572
6Dilated cardiomyopathy_Homo sapiens_hsa054141.86743819
7Hedgehog signaling pathway_Homo sapiens_hsa043401.85523114
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77978794
9Focal adhesion_Homo sapiens_hsa045101.72944291
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.72874502
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71416096
12ECM-receptor interaction_Homo sapiens_hsa045121.70556483
13Type II diabetes mellitus_Homo sapiens_hsa049301.70301581
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.67747656
15Insulin secretion_Homo sapiens_hsa049111.63402887
16Tryptophan metabolism_Homo sapiens_hsa003801.58776798
17Linoleic acid metabolism_Homo sapiens_hsa005911.56605187
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53497518
19Adherens junction_Homo sapiens_hsa045201.52400074
20Cardiac muscle contraction_Homo sapiens_hsa042601.52352459
21Serotonergic synapse_Homo sapiens_hsa047261.50619091
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.49797717
23Notch signaling pathway_Homo sapiens_hsa043301.48988776
24Wnt signaling pathway_Homo sapiens_hsa043101.48622183
25Hippo signaling pathway_Homo sapiens_hsa043901.48524926
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42747303
27Endometrial cancer_Homo sapiens_hsa052131.41963740
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.39264745
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.38888226
30Colorectal cancer_Homo sapiens_hsa052101.37892729
31Cocaine addiction_Homo sapiens_hsa050301.37715652
32Viral myocarditis_Homo sapiens_hsa054161.36765632
33Nitrogen metabolism_Homo sapiens_hsa009101.34257510
34Proteoglycans in cancer_Homo sapiens_hsa052051.31276101
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30483865
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29383133
37Melanogenesis_Homo sapiens_hsa049161.26679853
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25631464
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24204739
40Gap junction_Homo sapiens_hsa045401.23673041
41Chronic myeloid leukemia_Homo sapiens_hsa052201.22780501
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20987962
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.20239494
44MicroRNAs in cancer_Homo sapiens_hsa052061.19770205
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19634644
46Calcium signaling pathway_Homo sapiens_hsa040201.18879565
47Renal cell carcinoma_Homo sapiens_hsa052111.18467345
48Sulfur relay system_Homo sapiens_hsa041221.18302418
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18114543
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17590193
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17189955
52Estrogen signaling pathway_Homo sapiens_hsa049151.15589757
53Olfactory transduction_Homo sapiens_hsa047401.14425740
54Pyruvate metabolism_Homo sapiens_hsa006201.13933806
55RNA polymerase_Homo sapiens_hsa030201.12860530
56mTOR signaling pathway_Homo sapiens_hsa041501.12550706
57Insulin resistance_Homo sapiens_hsa049311.11408115
58Glioma_Homo sapiens_hsa052141.10828348
59Protein digestion and absorption_Homo sapiens_hsa049741.10741688
60Retinol metabolism_Homo sapiens_hsa008301.09407240
61Basal transcription factors_Homo sapiens_hsa030221.08392166
62TGF-beta signaling pathway_Homo sapiens_hsa043501.03805970
63Lysine degradation_Homo sapiens_hsa003101.03468332
64Cholinergic synapse_Homo sapiens_hsa047251.03373467
65AMPK signaling pathway_Homo sapiens_hsa041521.03165881
66Renin secretion_Homo sapiens_hsa049241.01855188
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00087431
68Insulin signaling pathway_Homo sapiens_hsa049100.99953119
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99893802
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98911672
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98148556
72Circadian entrainment_Homo sapiens_hsa047130.98000298
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.97403796
74Pathways in cancer_Homo sapiens_hsa052000.97159449
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96827257
76Dorso-ventral axis formation_Homo sapiens_hsa043200.95775209
77Rap1 signaling pathway_Homo sapiens_hsa040150.95746841
78Amoebiasis_Homo sapiens_hsa051460.94889742
79Prostate cancer_Homo sapiens_hsa052150.94094646
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.93896768
81Melanoma_Homo sapiens_hsa052180.93681145
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93193762
83Fanconi anemia pathway_Homo sapiens_hsa034600.93017595
84Dopaminergic synapse_Homo sapiens_hsa047280.92668009
85ErbB signaling pathway_Homo sapiens_hsa040120.90817716
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90442115
87Glycerolipid metabolism_Homo sapiens_hsa005610.88602200
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88447423
89Oxytocin signaling pathway_Homo sapiens_hsa049210.88353580
90Butanoate metabolism_Homo sapiens_hsa006500.87262271
91cAMP signaling pathway_Homo sapiens_hsa040240.87122391
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86000258
93Ether lipid metabolism_Homo sapiens_hsa005650.85645814
94N-Glycan biosynthesis_Homo sapiens_hsa005100.85599612
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84873264
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84297389
97Small cell lung cancer_Homo sapiens_hsa052220.83862387
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83565191
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83539878
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.83177692
101Prolactin signaling pathway_Homo sapiens_hsa049170.82644438
102Glycosaminoglycan degradation_Homo sapiens_hsa005310.82290583
103Caffeine metabolism_Homo sapiens_hsa002320.82274503
104Glucagon signaling pathway_Homo sapiens_hsa049220.81758579
105Pancreatic cancer_Homo sapiens_hsa052120.81212131
106GnRH signaling pathway_Homo sapiens_hsa049120.81119515
107Vitamin digestion and absorption_Homo sapiens_hsa049770.80510509
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80213106
109Circadian rhythm_Homo sapiens_hsa047100.79919155
110MAPK signaling pathway_Homo sapiens_hsa040100.79873669
111Chemical carcinogenesis_Homo sapiens_hsa052040.79554990
112PPAR signaling pathway_Homo sapiens_hsa033200.78624995
113Bladder cancer_Homo sapiens_hsa052190.78348971
114Tight junction_Homo sapiens_hsa045300.77742750
115Ras signaling pathway_Homo sapiens_hsa040140.75429013
116Gastric acid secretion_Homo sapiens_hsa049710.75128091
117Taste transduction_Homo sapiens_hsa047420.74298098
118Amphetamine addiction_Homo sapiens_hsa050310.73945664
119Platelet activation_Homo sapiens_hsa046110.73633284
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73320320
121HTLV-I infection_Homo sapiens_hsa051660.72507371
122Fat digestion and absorption_Homo sapiens_hsa049750.71642874
123Salivary secretion_Homo sapiens_hsa049700.71504069
124FoxO signaling pathway_Homo sapiens_hsa040680.70632422
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.70111189
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68562166
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67112526
128VEGF signaling pathway_Homo sapiens_hsa043700.66584632
129Long-term depression_Homo sapiens_hsa047300.65523884
130Glutamatergic synapse_Homo sapiens_hsa047240.63716786
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.63231383
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61599309
133GABAergic synapse_Homo sapiens_hsa047270.61403569
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61305784
135Non-small cell lung cancer_Homo sapiens_hsa052230.60820244
136Homologous recombination_Homo sapiens_hsa034400.60692686
137RNA degradation_Homo sapiens_hsa030180.60453950
138Endocytosis_Homo sapiens_hsa041440.60414472
139Ovarian steroidogenesis_Homo sapiens_hsa049130.60393392
140Morphine addiction_Homo sapiens_hsa050320.59895055
141Choline metabolism in cancer_Homo sapiens_hsa052310.59724877
142Selenocompound metabolism_Homo sapiens_hsa004500.54815968
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49142352
144Huntingtons disease_Homo sapiens_hsa050160.48305914
145ABC transporters_Homo sapiens_hsa020100.45003552
146Parkinsons disease_Homo sapiens_hsa050120.44830718
147Sulfur metabolism_Homo sapiens_hsa009200.44272658
148Steroid biosynthesis_Homo sapiens_hsa001000.44025943
149Alcoholism_Homo sapiens_hsa050340.43156536

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