TTC29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.71430382
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.55443769
3binding of sperm to zona pellucida (GO:0007339)9.54987345
4cell-cell recognition (GO:0009988)9.48036615
5reproduction (GO:0000003)8.82570112
6spermatid development (GO:0007286)8.79909791
7piRNA metabolic process (GO:0034587)8.65689678
8regulation of cilium movement (GO:0003352)7.98365696
9male meiosis (GO:0007140)7.97649641
10synaptonemal complex organization (GO:0070193)7.38008753
11single fertilization (GO:0007338)7.19475539
12synaptonemal complex assembly (GO:0007130)6.96096521
13ventricular system development (GO:0021591)6.59094825
14negative regulation of inclusion body assembly (GO:0090084)6.31062897
15sperm capacitation (GO:0048240)6.28363344
16fertilization (GO:0009566)6.08601272
17axoneme assembly (GO:0035082)5.95396367
18male meiosis I (GO:0007141)5.83589534
19spermatogenesis (GO:0007283)5.82578998
20male gamete generation (GO:0048232)5.80387521
21primary alcohol catabolic process (GO:0034310)5.72860544
22DNA methylation involved in gamete generation (GO:0043046)5.59375367
23gamete generation (GO:0007276)5.35553516
24regulation of inclusion body assembly (GO:0090083)5.27728104
25vitamin transmembrane transport (GO:0035461)5.26829581
26microtubule depolymerization (GO:0007019)5.26727798
27germ cell development (GO:0007281)5.00591423
28cellular process involved in reproduction in multicellular organism (GO:0022412)4.96911359
29chromosome organization involved in meiosis (GO:0070192)4.93161771
30organic cation transport (GO:0015695)4.83596202
31meiotic nuclear division (GO:0007126)4.79397054
32regulation of microtubule-based movement (GO:0060632)4.78363315
33meiosis I (GO:0007127)4.66095410
34ethanol metabolic process (GO:0006067)4.64565640
35spermatid nucleus differentiation (GO:0007289)4.62991154
36cell recognition (GO:0008037)4.60874376
37intraciliary transport (GO:0042073)4.56382704
38cell projection assembly (GO:0030031)4.56137094
39diterpenoid biosynthetic process (GO:0016102)4.54828631
40calcium ion-dependent exocytosis (GO:0017156)4.52522885
41microtubule severing (GO:0051013)4.51781363
42nucleoside diphosphate phosphorylation (GO:0006165)4.39708163
43one-carbon compound transport (GO:0019755)4.37974061
44multicellular organismal reproductive process (GO:0048609)4.19302694
45protein localization to cilium (GO:0061512)4.15645125
46left/right pattern formation (GO:0060972)4.14666023
47meiotic cell cycle (GO:0051321)4.11800339
48regulation of interleukin-5 production (GO:0032674)4.09564247
49pyrimidine-containing compound transmembrane transport (GO:0072531)4.04268524
50GTP biosynthetic process (GO:0006183)4.02129898
51seminiferous tubule development (GO:0072520)4.00936083
52response to xenobiotic stimulus (GO:0009410)3.99759976
53cilium organization (GO:0044782)3.98165328
54left/right axis specification (GO:0070986)3.97262909
55glomerular epithelial cell development (GO:0072310)3.93047255
56establishment of apical/basal cell polarity (GO:0035089)3.92033147
57microtubule-based movement (GO:0007018)3.91008112
58lung epithelium development (GO:0060428)3.87399192
59chaperone-mediated protein complex assembly (GO:0051131)3.86249871
60cilium morphogenesis (GO:0060271)3.76674874
61cilium assembly (GO:0042384)3.75441566
62negative regulation of B cell mediated immunity (GO:0002713)3.74137912
63negative regulation of immunoglobulin mediated immune response (GO:0002890)3.74137912
64establishment or maintenance of monopolar cell polarity (GO:0061339)3.69518677
65establishment of monopolar cell polarity (GO:0061162)3.69518677
66retinoic acid metabolic process (GO:0042573)3.58255768
67UTP biosynthetic process (GO:0006228)3.58178374
68ethanol oxidation (GO:0006069)3.58139265
69cellular component assembly involved in morphogenesis (GO:0010927)3.58021606
70protein polyglutamylation (GO:0018095)3.56984391
71glycerol ether metabolic process (GO:0006662)3.55767160
72negative regulation of T cell differentiation in thymus (GO:0033085)3.50203870
73establishment of planar polarity (GO:0001736)3.46624626
74establishment of tissue polarity (GO:0007164)3.46624626
75tolerance induction (GO:0002507)3.45826441
76genitalia morphogenesis (GO:0035112)3.40766199
77lateral ventricle development (GO:0021670)3.39972327
78terpenoid biosynthetic process (GO:0016114)3.37281318
79monoubiquitinated protein deubiquitination (GO:0035520)3.34612219
80smoothened signaling pathway (GO:0007224)3.33288689
81retinal rod cell development (GO:0046548)3.32892590
82regulation of interleukin-13 production (GO:0032656)3.31097517
83determination of left/right symmetry (GO:0007368)3.30536687
84multicellular organismal development (GO:0007275)3.30279022
85ether metabolic process (GO:0018904)3.28817077
86protein refolding (GO:0042026)3.27968834
87cytoplasmic microtubule organization (GO:0031122)3.27532077
88UTP metabolic process (GO:0046051)3.23334684
89negative regulation of humoral immune response (GO:0002921)3.23203938
90gene silencing by RNA (GO:0031047)3.21058152
91determination of bilateral symmetry (GO:0009855)3.18842720
92nonmotile primary cilium assembly (GO:0035058)3.14663655
93centriole assembly (GO:0098534)3.14251253
94specification of symmetry (GO:0009799)3.11371933
95carnitine metabolic process (GO:0009437)3.09116250
96microtubule bundle formation (GO:0001578)3.08410774
97chromosome condensation (GO:0030261)3.07768045
98centriole replication (GO:0007099)3.06556982
99organelle assembly (GO:0070925)3.02606471
100meiotic cell cycle process (GO:1903046)3.02157024
101synapsis (GO:0007129)3.01605404
102microtubule-based process (GO:0007017)3.00375165
103alditol metabolic process (GO:0019400)2.97121231
104DNA packaging (GO:0006323)2.95875138
105negative regulation of organelle assembly (GO:1902116)2.95212137
106positive regulation of smoothened signaling pathway (GO:0045880)2.88372564
107regulation of meiosis I (GO:0060631)2.86438093
108photoreceptor cell maintenance (GO:0045494)2.84370946
109amino-acid betaine transport (GO:0015838)2.82153249
110carnitine transport (GO:0015879)2.82153249
111protein K11-linked deubiquitination (GO:0035871)2.81932231
112positive regulation of tolerance induction (GO:0002645)2.78126639
113regulation of centriole replication (GO:0046599)2.77357078
114carnitine transmembrane transport (GO:1902603)2.76825341
115guanosine-containing compound biosynthetic process (GO:1901070)2.74690990
116negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.74429569
117polyol catabolic process (GO:0046174)2.73932130
118glycerol metabolic process (GO:0006071)2.69937187
119microtubule polymerization or depolymerization (GO:0031109)2.69929481
120regulation of spindle checkpoint (GO:0090231)2.68820992
121retinal cone cell development (GO:0046549)2.68757598
122exogenous drug catabolic process (GO:0042738)2.67452691
123regulation of protein polyubiquitination (GO:1902914)2.60366456
124CTP biosynthetic process (GO:0006241)2.58551471
125CTP metabolic process (GO:0046036)2.58551471
126glutathione derivative metabolic process (GO:1901685)2.57436222
127glutathione derivative biosynthetic process (GO:1901687)2.57436222
128excretion (GO:0007588)2.57359887
129single strand break repair (GO:0000012)2.56708354
130sequestering of actin monomers (GO:0042989)2.56136226
131phosphatidylethanolamine biosynthetic process (GO:0006646)2.56100383
132nucleus organization (GO:0006997)2.54774841
133primary alcohol metabolic process (GO:0034308)2.53560665
134retinol metabolic process (GO:0042572)2.52814170
135lactate metabolic process (GO:0006089)2.51687643
136O-glycan processing (GO:0016266)2.49782549
137phosphatidylethanolamine metabolic process (GO:0046337)2.49276980
138regulation of germinal center formation (GO:0002634)2.49193975
139amino-acid betaine metabolic process (GO:0006577)2.49177661
140regulation of collateral sprouting (GO:0048670)2.47070854
141heart looping (GO:0001947)2.45746139
142regulation of microtubule depolymerization (GO:0031114)2.42544240
143mitochondrion degradation (GO:0000422)2.40171593
144nucleotide phosphorylation (GO:0046939)2.38589019
145aldehyde catabolic process (GO:0046185)2.37440205
146phosphatidylcholine biosynthetic process (GO:0006656)2.35738958
147regulation of smoothened signaling pathway (GO:0008589)2.34901948
148regulation of cilium assembly (GO:1902017)2.34867109
149embryonic heart tube morphogenesis (GO:0003143)2.30007654
150CDP-diacylglycerol biosynthetic process (GO:0016024)2.29345654
151cilium or flagellum-dependent cell motility (GO:0001539)14.6096535
152axonemal dynein complex assembly (GO:0070286)13.5135644
153fusion of sperm to egg plasma membrane (GO:0007342)13.1618464
154cell wall macromolecule catabolic process (GO:0016998)11.5983397
155cell wall macromolecule metabolic process (GO:0044036)11.5983397
156cilium movement (GO:0003341)11.5900712
157sperm motility (GO:0030317)11.5091715
158epithelial cilium movement (GO:0003351)11.2835059
159acrosome assembly (GO:0001675)11.1597764
160multicellular organism reproduction (GO:0032504)10.6630266
161sperm-egg recognition (GO:0035036)10.6050440
162motile cilium assembly (GO:0044458)10.5451210
163plasma membrane fusion (GO:0045026)10.0305248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.83321760
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.45035413
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50460127
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.08937466
5EZH2_22144423_ChIP-Seq_EOC_Human4.07571975
6DROSHA_22980978_ChIP-Seq_HELA_Human3.10741727
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68679274
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65822398
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.43080291
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.41887717
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.37252575
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.20702501
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17952684
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16663149
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14701519
16VDR_22108803_ChIP-Seq_LS180_Human2.02927628
17* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92206201
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.91867330
19ZNF274_21170338_ChIP-Seq_K562_Hela1.91192534
20ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88968888
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82511818
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.78399230
23TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.76460949
24KAP1_22055183_ChIP-Seq_ESCs_Mouse1.76418493
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.74022399
26PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69748664
27NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69425119
28TOP2B_26459242_ChIP-Seq_MCF-7_Human1.69378832
29RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.67993405
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.66330196
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.66249694
32STAT1_17558387_ChIP-Seq_HELA_Human1.59113461
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57001183
34NFE2_27457419_Chip-Seq_LIVER_Mouse1.56088078
35TP53_18474530_ChIP-ChIP_U2OS_Human1.56011265
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54032394
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52950000
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52922893
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.50852639
40GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50417393
41SMC4_20622854_ChIP-Seq_HELA_Human1.50140612
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49951312
43AHR_22903824_ChIP-Seq_MCF-7_Human1.49946495
44RNF2_27304074_Chip-Seq_NSC_Mouse1.46362918
45* SMAD4_21799915_ChIP-Seq_A2780_Human1.46091345
46TP63_23658742_ChIP-Seq_EP156T_Human1.45901623
47* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45692524
48CBP_20019798_ChIP-Seq_JUKART_Human1.45423627
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45423627
50KDM2B_26808549_Chip-Seq_REH_Human1.42892975
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40797691
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.39938313
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38362683
54SOX2_22085726_ChIP-Seq_NPCs_Mouse1.38021105
55FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38012101
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37374496
57ETV1_20927104_ChIP-Seq_GIST48_Human1.37031293
58GATA3_21867929_ChIP-Seq_CD8_Mouse1.36845476
59* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36816038
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.36721635
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34111164
62STAT1_20625510_ChIP-Seq_HELA_Human1.33101754
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.32151413
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31995133
65AR_21572438_ChIP-Seq_LNCaP_Human1.31567047
66PHF8_20622853_ChIP-Seq_HELA_Human1.30715361
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30587545
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30277175
69PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.29725412
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29460905
71HNFA_21074721_ChIP-Seq_CACO-2_Human1.29290837
72TP63_22573176_ChIP-Seq_HFKS_Human1.29079456
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.28790849
74FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28668671
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27714157
76LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.27642465
77* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26629848
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.26364617
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25737004
80TDRD3_21172665_ChIP-Seq_MCF-7_Human1.24909274
81CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24126946
82* STAT3_23295773_ChIP-Seq_U87_Human1.22771715
83CTCF_27219007_Chip-Seq_Bcells_Human1.22769258
84SMRT_27268052_Chip-Seq_Bcells_Human1.22642362
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.21948112
86REST_21632747_ChIP-Seq_MESCs_Mouse1.21941863
87RBPJ_21746931_ChIP-Seq_IB4_Human1.20778616
88FUS_26573619_Chip-Seq_HEK293_Human1.20656645
89TCF4_22108803_ChIP-Seq_LS180_Human1.20385077
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19236881
91TRIM28_21343339_ChIP-Seq_HEK293_Human1.18789546
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.18762260
93NFYA_21822215_ChIP-Seq_K562_Human1.18747364
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18636085
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18376505
96P53_22387025_ChIP-Seq_ESCs_Mouse1.18191352
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17652641
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17652641
99SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.17246463
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.16179239
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.15788849
102KLF5_25053715_ChIP-Seq_YYC3_Human1.15537661
103ESR1_20079471_ChIP-ChIP_T-47D_Human1.15158190
104RUNX2_22187159_ChIP-Seq_PCA_Human1.14968120
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.14755261
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14528717
107PHF8_20622854_ChIP-Seq_HELA_Human1.14184174
108* GF1_26923725_Chip-Seq_HPCs_Mouse1.14034021
109CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13985583
110P300_18555785_Chip-Seq_ESCs_Mouse1.13918624
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.13757264
112CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13377414
113ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13359487
114CMYC_18555785_Chip-Seq_ESCs_Mouse1.13217582
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.12617729
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12561182
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12538648
118P300_19829295_ChIP-Seq_ESCs_Human1.12381250
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12049872
120PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11917877
121ELF1_20517297_ChIP-Seq_JURKAT_Human1.11489123
122P53_21459846_ChIP-Seq_SAOS-2_Human1.11105759
123SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10284565
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10069297
125GATA3_21867929_ChIP-Seq_TH1_Mouse1.09297816
126ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08289234
127GBX2_23144817_ChIP-Seq_PC3_Human1.07579555
128TCF4_23295773_ChIP-Seq_U87_Human1.07496591
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.07459198
130CEBPB_22108803_ChIP-Seq_LS180_Human1.07414076
131CTCF_20526341_ChIP-Seq_ESCs_Human1.07367568
132AR_25329375_ChIP-Seq_VCAP_Human1.06446308
133* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06203089
134MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05945121
135NANOG_20526341_ChIP-Seq_ESCs_Human1.05736269
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05247600
137ER_23166858_ChIP-Seq_MCF-7_Human1.04632213
138HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04609638
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04359309
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03828988
141CBP_21632823_ChIP-Seq_H3396_Human1.03807951
142RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02047410
143GATA6_21074721_ChIP-Seq_CACO-2_Human1.01997370
144GF1B_26923725_Chip-Seq_HPCs_Mouse1.01724064
145* AR_19668381_ChIP-Seq_PC3_Human1.00507512
146RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00440370
147CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00329450
148P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00017483
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99999443
150SOX2_18555785_Chip-Seq_ESCs_Mouse0.99911236
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99292800
152OCT4_20526341_ChIP-Seq_ESCs_Human0.98875230
153E2F1_18555785_Chip-Seq_ESCs_Mouse0.97742164
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97565339
155NFYB_21822215_ChIP-Seq_K562_Human0.97207660
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96552665
157LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96385950
158PU1_27457419_Chip-Seq_LIVER_Mouse0.96080060
159FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95635789
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95471006
161TBL1_22424771_ChIP-Seq_293T_Human0.94058365
162SPI1_26923725_Chip-Seq_HPCs_Mouse0.93721264
163ZFX_18555785_Chip-Seq_ESCs_Mouse0.93365733
164CTCF_18555785_Chip-Seq_ESCs_Mouse0.92486590
165ERG_20517297_ChIP-Seq_VCAP_Human0.91631514
166SOX9_26525672_Chip-Seq_HEART_Mouse0.91085349
167* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89999102
168* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89316376
169TAF15_26573619_Chip-Seq_HEK293_Human0.88934608
170ESET_19884257_ChIP-Seq_ESCs_Mouse0.88886632
171FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88551011
172FOXA1_25329375_ChIP-Seq_VCAP_Human0.88551011
173STAT3_18555785_ChIP-Seq_MESCs_Mouse0.88467530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.96002483
2MP0001929_abnormal_gametogenesis5.49997128
3MP0008877_abnormal_DNA_methylation4.85219844
4MP0002653_abnormal_ependyma_morphology4.16005103
5MP0008789_abnormal_olfactory_epithelium3.87828490
6MP0002210_abnormal_sex_determination3.75016946
7MP0002161_abnormal_fertility/fecundity3.19777576
8MP0001145_abnormal_male_reproductive3.12802839
9MP0005499_abnormal_olfactory_system3.09711241
10MP0005394_taste/olfaction_phenotype3.09711241
11MP0009780_abnormal_chondrocyte_physiolo2.82378502
12MP0000653_abnormal_sex_gland2.73259415
13MP0005623_abnormal_meninges_morphology2.67035593
14MP0004043_abnormal_pH_regulation2.52107179
15MP0002277_abnormal_respiratory_mucosa2.43356410
16MP0002160_abnormal_reproductive_system2.33263592
17MP0000566_synostosis2.27425967
18MP0002638_abnormal_pupillary_reflex2.13053107
19MP0005670_abnormal_white_adipose2.06590360
20MP0005410_abnormal_fertilization14.7003539
21MP0001485_abnormal_pinna_reflex1.83118397
22MP0003890_abnormal_embryonic-extraembry1.76561580
23MP0000383_abnormal_hair_follicle1.72844686
24MP0005083_abnormal_biliary_tract1.68615545
25MP0003136_yellow_coat_color1.65973635
26MP0003718_maternal_effect1.64822712
27MP0008057_abnormal_DNA_replication1.61774496
28MP0002282_abnormal_trachea_morphology1.59594726
29MP0001984_abnormal_olfaction1.59048504
30MP0005395_other_phenotype1.55030725
31MP0002168_other_aberrant_phenotype1.50380597
32MP0010030_abnormal_orbit_morphology1.46157954
33MP0010678_abnormal_skin_adnexa1.42040137
34MP0008058_abnormal_DNA_repair1.39345571
35MP0002734_abnormal_mechanical_nocicepti1.35013627
36MP0002234_abnormal_pharynx_morphology1.33348508
37MP0009046_muscle_twitch1.32200460
38MP0008995_early_reproductive_senescence1.26605778
39MP0000026_abnormal_inner_ear1.23484485
40MP0005389_reproductive_system_phenotype1.23179533
41MP0005647_abnormal_sex_gland1.20187068
42MP0002233_abnormal_nose_morphology1.18802971
43MP0005248_abnormal_Harderian_gland1.13400716
44MP0004233_abnormal_muscle_weight1.10893565
45MP0001765_abnormal_ion_homeostasis1.07209731
46MP0002928_abnormal_bile_duct1.06938942
47MP0001963_abnormal_hearing_physiology1.05007245
48MP0000678_abnormal_parathyroid_gland1.03990052
49MP0003646_muscle_fatigue1.03931284
50MP0004133_heterotaxia1.00483862
51MP0000049_abnormal_middle_ear0.98965345
52MP0006276_abnormal_autonomic_nervous0.98757325
53MP0002909_abnormal_adrenal_gland0.97726420
54MP0003950_abnormal_plasma_membrane0.97031831
55MP0000955_abnormal_spinal_cord0.94848685
56MP0010094_abnormal_chromosome_stability0.94784411
57MP0002735_abnormal_chemical_nociception0.92600815
58MP0000631_abnormal_neuroendocrine_gland0.90503129
59MP0000778_abnormal_nervous_system0.88075360
60MP0001293_anophthalmia0.86703501
61MP0002822_catalepsy0.82485333
62MP0003880_abnormal_central_pattern0.81506055
63MP0001486_abnormal_startle_reflex0.79041195
64MP0001346_abnormal_lacrimal_gland0.78535642
65MP0005171_absent_coat_pigmentation0.77234842
66MP0001502_abnormal_circadian_rhythm0.76852571
67MP0003011_delayed_dark_adaptation0.75513347
68MP0001970_abnormal_pain_threshold0.74794620
69MP0003937_abnormal_limbs/digits/tail_de0.74365784
70MP0005551_abnormal_eye_electrophysiolog0.73873033
71MP0003656_abnormal_erythrocyte_physiolo0.72791751
72MP0003786_premature_aging0.72629767
73MP0002272_abnormal_nervous_system0.70010327
74MP0002882_abnormal_neuron_morphology0.66827554
75MP0001299_abnormal_eye_distance/0.66677968
76MP0004885_abnormal_endolymph0.65091054
77MP0005646_abnormal_pituitary_gland0.64386562
78MP0002572_abnormal_emotion/affect_behav0.64302490
79MP0005253_abnormal_eye_physiology0.62476134
80MP0005085_abnormal_gallbladder_physiolo0.61837610
81MP0002876_abnormal_thyroid_physiology0.61566112
82MP0000681_abnormal_thyroid_gland0.60476958
83MP0001545_abnormal_hematopoietic_system0.57705619
84MP0005397_hematopoietic_system_phenotyp0.57705619
85MP0005391_vision/eye_phenotype0.57442708
86MP0003115_abnormal_respiratory_system0.56704247
87MP0002116_abnormal_craniofacial_bone0.55775784
88MP0001324_abnormal_eye_pigmentation0.55494982
89MP0005636_abnormal_mineral_homeostasis0.55311070
90MP0003938_abnormal_ear_development0.51985047
91MP0009745_abnormal_behavioral_response0.51762671
92MP0006292_abnormal_olfactory_placode0.51668087
93MP0006072_abnormal_retinal_apoptosis0.50515275
94MP0009765_abnormal_xenobiotic_induced0.49950368
95MP0002132_abnormal_respiratory_system0.49101200
96MP0005377_hearing/vestibular/ear_phenot0.49040064
97MP0003878_abnormal_ear_physiology0.49040064
98MP0002102_abnormal_ear_morphology0.48382621
99MP0005408_hypopigmentation0.47694367
100MP0009703_decreased_birth_body0.46908801
101MP0003699_abnormal_female_reproductive0.46774905
102MP0002067_abnormal_sensory_capabilities0.46450023
103MP0000358_abnormal_cell_content/0.45434589
104MP0003123_paternal_imprinting0.44703550
105MP0005388_respiratory_system_phenotype0.44497245
106MP0002133_abnormal_respiratory_system0.44497245
107MP0005666_abnormal_adipose_tissue0.43069933
108MP0002092_abnormal_eye_morphology0.42748006
109MP0004808_abnormal_hematopoietic_stem0.41752496
110MP0003861_abnormal_nervous_system0.41750359
111MP0003942_abnormal_urinary_system0.40317418
112MP0001119_abnormal_female_reproductive0.39936712
113MP0002405_respiratory_system_inflammati0.39011477
114MP0002152_abnormal_brain_morphology0.35721511
115MP0003634_abnormal_glial_cell0.34568707
116MP0004134_abnormal_chest_morphology0.33106318
117MP0008875_abnormal_xenobiotic_pharmacok0.32174675
118MP0000462_abnormal_digestive_system0.32100125
119MP0002249_abnormal_larynx_morphology0.31359111
120MP0009115_abnormal_fat_cell0.30989197
121MP0005195_abnormal_posterior_eye0.30946080
122MP0003045_fibrosis0.29961616
123MP0000534_abnormal_ureter_morphology0.29604544
124MP0001851_eye_inflammation0.29294508
125MP0004019_abnormal_vitamin_homeostasis0.29228954
126MP0008007_abnormal_cellular_replicative0.29063697
127MP0001727_abnormal_embryo_implantation0.28744416
128MP0008004_abnormal_stomach_pH0.28336823
129MP0005167_abnormal_blood-brain_barrier0.27262176
130MP0003633_abnormal_nervous_system0.27167017
131MP0000432_abnormal_head_morphology0.26740800
132MP0000427_abnormal_hair_cycle0.26692013
133MP0002084_abnormal_developmental_patter0.26267073
134MP0008932_abnormal_embryonic_tissue0.26111598
135MP0003879_abnormal_hair_cell0.25414664
136MP0002971_abnormal_brown_adipose0.24997273
137MP0002269_muscular_atrophy0.24631335
138MP0002295_abnormal_pulmonary_circulatio0.24016867
139MP0001986_abnormal_taste_sensitivity0.23869639
140MP0005423_abnormal_somatic_nervous0.22990252
141MP0001764_abnormal_homeostasis0.22854385
142MP0001968_abnormal_touch/_nociception0.22071787
143MP0001919_abnormal_reproductive_system0.21913183
144MP0003329_amyloid_beta_deposits0.21906685
145MP0000313_abnormal_cell_death0.21571086
146MP0002752_abnormal_somatic_nervous0.21496568
147MP0010307_abnormal_tumor_latency0.21134738
148MP0002109_abnormal_limb_morphology0.21124663
149MP0002736_abnormal_nociception_after0.20637553
150MP0001440_abnormal_grooming_behavior0.20513835
151MP0004036_abnormal_muscle_relaxation0.19503424
152MP0003111_abnormal_nucleus_morphology0.19474043
153MP0001730_embryonic_growth_arrest0.18570513
154MP0003077_abnormal_cell_cycle0.18438270
155MP0001270_distended_abdomen0.17964004
156MP0002557_abnormal_social/conspecific_i0.17807131
157MP0002229_neurodegeneration0.17554120

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.63552431
2Abnormal respiratory epithelium morphology (HP:0012253)9.63552431
3Rhinitis (HP:0012384)9.07271265
4Chronic bronchitis (HP:0004469)7.84759367
5Nasal polyposis (HP:0100582)6.35684296
6Infertility (HP:0000789)5.88012142
7Bronchiectasis (HP:0002110)5.43657557
8Abnormality of the nasal mucosa (HP:0000433)5.28465419
9Bronchitis (HP:0012387)4.43552762
10Nephronophthisis (HP:0000090)3.79051760
11Recurrent sinusitis (HP:0011108)3.76675429
12Male infertility (HP:0003251)3.37566557
13Recurrent otitis media (HP:0000403)3.16283301
14Atelectasis (HP:0100750)3.02208650
15Medial flaring of the eyebrow (HP:0010747)2.95622488
16Abnormality of the renal medulla (HP:0100957)2.88642402
17Molar tooth sign on MRI (HP:0002419)2.78209055
18Abnormality of midbrain morphology (HP:0002418)2.78209055
19Tubulointerstitial nephritis (HP:0001970)2.71094912
20Supernumerary spleens (HP:0009799)2.59567147
21Chronic otitis media (HP:0000389)2.49683582
22Hyperactive renin-angiotensin system (HP:0000841)2.44001820
23Chronic sinusitis (HP:0011109)2.43046834
24Abnormal spermatogenesis (HP:0008669)2.39684707
25Pancreatic fibrosis (HP:0100732)2.38419253
26Fibular hypoplasia (HP:0003038)2.25047368
27Postaxial foot polydactyly (HP:0001830)2.21342719
28Recurrent bronchitis (HP:0002837)2.16081692
29Congenital hepatic fibrosis (HP:0002612)2.13860485
30Congenital primary aphakia (HP:0007707)2.12288872
31Facial cleft (HP:0002006)2.12002454
32Gait imbalance (HP:0002141)2.11773754
33Abnormality of the lower motor neuron (HP:0002366)2.10147833
34True hermaphroditism (HP:0010459)2.08730673
35Tubular atrophy (HP:0000092)2.05349175
36Tubulointerstitial abnormality (HP:0001969)2.05314345
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.8257463
38Dynein arm defect of respiratory motile cilia (HP:0012255)11.7628731
39Absent/shortened dynein arms (HP:0200106)11.7628731
40Abnormal respiratory motile cilium physiology (HP:0012261)11.5334929
41Abnormal ciliary motility (HP:0012262)10.2788822
42Median cleft lip (HP:0000161)1.95145191
43Abnormality of dentin (HP:0010299)1.86657569
44Nephrogenic diabetes insipidus (HP:0009806)1.85390143
45Azoospermia (HP:0000027)1.84288583
46Gonadotropin excess (HP:0000837)1.83313029
47Occipital encephalocele (HP:0002085)1.80733041
48Cystic liver disease (HP:0006706)1.80447470
49Bile duct proliferation (HP:0001408)1.79222886
50Abnormal biliary tract physiology (HP:0012439)1.79222886
51Oculomotor apraxia (HP:0000657)1.78905276
52Aplasia/Hypoplasia of the spleen (HP:0010451)1.78555760
53Postaxial hand polydactyly (HP:0001162)1.77633519
54Furrowed tongue (HP:0000221)1.77554860
55Genital tract atresia (HP:0001827)1.76878523
56Asplenia (HP:0001746)1.76141564
57Aplasia/Hypoplasia of the tongue (HP:0010295)1.75548650
58Abnormality of the dental root (HP:0006486)1.74148156
59Taurodontia (HP:0000679)1.74148156
60Abnormality of permanent molar morphology (HP:0011071)1.74148156
61Stage 5 chronic kidney disease (HP:0003774)1.73675689
62Vaginal atresia (HP:0000148)1.72476233
63Decreased circulating renin level (HP:0003351)1.69732102
64Impulsivity (HP:0100710)1.62176158
65Abnormality of molar (HP:0011077)1.62073964
66Abnormality of molar morphology (HP:0011070)1.62073964
67Poor coordination (HP:0002370)1.60880696
68Amyotrophic lateral sclerosis (HP:0007354)1.60241468
69Abnormality of the dental pulp (HP:0006479)1.58906220
70Dyschromatopsia (HP:0007641)1.58007232
71Renal dysplasia (HP:0000110)1.55005730
72Aplasia/Hypoplasia of the lens (HP:0008063)1.53728861
73Short ribs (HP:0000773)1.53610615
74Pancreatic cysts (HP:0001737)1.52445689
75Tubulointerstitial fibrosis (HP:0005576)1.51730338
76Chronic hepatic failure (HP:0100626)1.50876230
77Renal salt wasting (HP:0000127)1.45985221
78Hyperkalemia (HP:0002153)1.45391775
79Abnormality of the renal cortex (HP:0011035)1.42786308
80Impaired proprioception (HP:0010831)1.39986928
81Cone-rod dystrophy (HP:0000548)1.38275497
82Cholecystitis (HP:0001082)1.37775087
83Abnormal gallbladder physiology (HP:0012438)1.37775087
84Hyperaldosteronism (HP:0000859)1.37116030
85Aplasia/Hypoplasia of the fibula (HP:0006492)1.36511629
86Microglossia (HP:0000171)1.36264010
87Bell-shaped thorax (HP:0001591)1.34706425
88Abnormal drinking behavior (HP:0030082)1.34068254
89Polydipsia (HP:0001959)1.34068254
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.27870559
91Preaxial hand polydactyly (HP:0001177)1.25180292
92Retinitis pigmentosa (HP:0000510)1.25117365
93Narrow forehead (HP:0000341)1.24203597
9411 pairs of ribs (HP:0000878)1.23452150
95Nephropathy (HP:0000112)1.23249659
96Abnormality of renal excretion (HP:0011036)1.22361758
97Male pseudohermaphroditism (HP:0000037)1.21953526
98Short thorax (HP:0010306)1.20269137
99Abnormality of macular pigmentation (HP:0008002)1.20041864
100Broad distal phalanx of finger (HP:0009836)1.19973712
101Aganglionic megacolon (HP:0002251)1.18491634
102Multicystic kidney dysplasia (HP:0000003)1.17399985
103Bifid tongue (HP:0010297)1.16510028
104Abnormality of ocular smooth pursuit (HP:0000617)1.16010036
105Abdominal situs inversus (HP:0003363)1.16004351
106Abnormality of abdominal situs (HP:0011620)1.16004351
107Abnormality of renin-angiotensin system (HP:0000847)1.14561894
108Prominent nasal bridge (HP:0000426)1.14253045
109Optic nerve coloboma (HP:0000588)1.13157089
110Abnormality of saccadic eye movements (HP:0000570)1.13101344
111Polyuria (HP:0000103)1.12870598
112Absent frontal sinuses (HP:0002688)1.12521827
113Abnormal rod and cone electroretinograms (HP:0008323)1.11694034
114Anencephaly (HP:0002323)1.11475130
115Broad foot (HP:0001769)1.10724756
116Intellectual disability, moderate (HP:0002342)1.09506832
117Bifid scrotum (HP:0000048)1.09104484
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.08841467
119Sclerocornea (HP:0000647)1.08774320
120Holoprosencephaly (HP:0001360)1.08082203
121Decreased central vision (HP:0007663)1.07660044
122Polycystic kidney dysplasia (HP:0000113)1.06399854
123Portal hypertension (HP:0001409)1.04861158
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.04228646
125Upper motor neuron abnormality (HP:0002127)1.03754432
126Abnormality of chloride homeostasis (HP:0011422)1.01932473
127Heterotopia (HP:0002282)1.01608045
128Constricted visual fields (HP:0001133)1.01496860
129Central scotoma (HP:0000603)1.01060566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.73935386
2PDK48.73935386
3PDK25.66777023
4TESK14.67153987
5MST44.17111367
6PNCK3.66615969
7PRKD33.58107467
8EPHA23.05908875
9ICK3.04605567
10MAPK152.59274442
11LATS12.50661759
12PTK2B2.47939738
13WNK42.10841605
14STK392.07115825
15BCR2.05621126
16NME11.66892027
17NEK21.62849120
18STK241.48157924
19MAP4K21.37110796
20STK381.30951231
21MAP3K21.27850134
22WEE11.20675630
23INSRR1.17080811
24EPHA31.16765329
25TSSK61.09463297
26IRAK11.07023713
27MAP3K41.04871362
28TLK11.00486985
29MST1R0.99534144
30ERBB30.96653709
31DYRK1B0.95125891
32WNK10.94177253
33LMTK20.91322362
34PDK10.90948982
35TRIM280.89269555
36TESK20.83797469
37EPHA40.83032917
38PASK0.82720074
39PBK0.80585515
40STK30.80456732
41LATS20.79726864
42MET0.76722263
43TYRO30.75309867
44MAP2K20.72146507
45TTK0.70889409
46PRKCI0.69778467
47NLK0.66244077
48CHEK20.65142266
49GRK10.63330082
50STK38L0.62891759
51CCNB10.62216615
52MAP3K70.61512115
53DYRK30.59911072
54TIE10.59846113
55BCKDK0.56162286
56CDC70.55154448
57MAP3K120.52533440
58STK160.52332585
59ACVR1B0.49671403
60ERBB20.49128718
61PINK10.48703693
62CAMK1G0.45930803
63NTRK20.45131644
64PLK40.44818878
65EEF2K0.43889363
66CHEK10.42698076
67ARAF0.42215463
68FER0.41640067
69PRKCG0.40357999
70MAP2K60.38319632
71MAPKAPK50.37582503
72PRKAA20.37419626
73DYRK1A0.36951200
74PDPK10.36583597
75LRRK20.35400259
76ATR0.35107334
77CASK0.35038431
78ATM0.34716746
79CDK120.32104417
80BRSK20.31870982
81OXSR10.30974477
82PAK20.30707292
83STK100.29780725
84PLK10.29632025
85IRAK20.29402456
86PAK10.29339711
87CDK90.26581898
88DYRK20.26574264
89EPHB10.26385494
90MAPK130.25371088
91TRPM70.25196206
92CAMK2A0.24710201
93ROCK10.23921436
94GRK50.23853776
95PRKCE0.22998794
96PRKCD0.22626419
97CSNK1A1L0.22505320
98CSNK1G20.22035422
99MUSK0.21832228
100CAMKK10.21209457
101ZAK0.21069011
102AURKA0.20998524
103VRK10.20949741
104MAP3K30.20808628
105NEK90.20367306
106ROCK20.20269720
107CAMK2G0.19081501
108MAP2K40.18233618
109ABL10.17965253
110RPS6KA20.17815045
111FRK0.17760954
112ADRBK20.17584405
113CDK190.16625238
114BRAF0.14867132
115RPS6KB10.14323859
116MTOR0.13743091
117MAP2K70.12948467
118PRKAA10.11099137
119CDK30.11012542
120PRKACG0.10541397
121CSNK2A10.10365700
122PRKCZ0.10141528
123BRSK10.09053373
124PRKDC0.08157421
125CSNK2A20.07815019
126PRKG10.07406656
127MARK30.06886461
128NEK60.06389488
129PRKCQ0.05867175
130RPS6KA10.05533437
131CSNK1D0.05369231
132MARK20.04871266
133CSK0.04415327
134RIPK10.04372936
135CDK150.03115063
136GSK3B0.02833113
137PKN10.02818299
138EGFR0.02620652
139MAPK80.02246316
140CDK11A0.02148660
141PAK40.01981271
142CDK10.01781411
143PRKACA0.01769186
144MAPK100.01751242
145PLK30.01480557
146RIPK40.01464000
147ZAP700.01297458
148CDK180.00798109
149PRKACB0.00755665
150MAPKAPK30.00600430
151CDK20.00589329
152PRKCB0.00546405
153YES10.00506655
154GSK3A0.00500563
155PLK20.00273782
156BMPR1B0.00256901
157CDC42BPA-0.0054727
158RPS6KA4-0.0020921
159CDK14-0.0007252

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.12119647
2Phenylalanine metabolism_Homo sapiens_hsa003604.73725411
3Pyruvate metabolism_Homo sapiens_hsa006204.04436160
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.95126937
5Histidine metabolism_Homo sapiens_hsa003403.86935609
6Tyrosine metabolism_Homo sapiens_hsa003503.44157126
7Fatty acid biosynthesis_Homo sapiens_hsa000613.20119962
8Propanoate metabolism_Homo sapiens_hsa006403.07870980
9beta-Alanine metabolism_Homo sapiens_hsa004102.81249340
10Basal transcription factors_Homo sapiens_hsa030222.71178929
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.69758464
12Glucagon signaling pathway_Homo sapiens_hsa049222.52237224
13Fanconi anemia pathway_Homo sapiens_hsa034602.50403122
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36774362
15Huntingtons disease_Homo sapiens_hsa050162.35421825
16Dorso-ventral axis formation_Homo sapiens_hsa043202.32829779
17Linoleic acid metabolism_Homo sapiens_hsa005912.31990430
18Selenocompound metabolism_Homo sapiens_hsa004502.24608576
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12670599
20Pentose phosphate pathway_Homo sapiens_hsa000302.05791506
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.99826934
22Glycerolipid metabolism_Homo sapiens_hsa005611.93490773
23Carbohydrate digestion and absorption_Homo sapiens_hsa049731.89297427
24Oocyte meiosis_Homo sapiens_hsa041141.89102053
25Caffeine metabolism_Homo sapiens_hsa002321.87068651
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76403755
27PPAR signaling pathway_Homo sapiens_hsa033201.72334804
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65728210
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.62177398
30Amphetamine addiction_Homo sapiens_hsa050311.54649845
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.51638413
32Peroxisome_Homo sapiens_hsa041461.51238243
33Tight junction_Homo sapiens_hsa045301.40192665
34Fructose and mannose metabolism_Homo sapiens_hsa000511.38913712
35Nicotine addiction_Homo sapiens_hsa050331.36213293
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.34762571
37Mineral absorption_Homo sapiens_hsa049781.28188727
38Cardiac muscle contraction_Homo sapiens_hsa042601.24653728
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.23943034
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.23484390
41Carbon metabolism_Homo sapiens_hsa012001.20359697
42Renin secretion_Homo sapiens_hsa049241.20082511
43Ether lipid metabolism_Homo sapiens_hsa005651.18593881
44Basal cell carcinoma_Homo sapiens_hsa052171.16050013
45Purine metabolism_Homo sapiens_hsa002301.15846605
46Antigen processing and presentation_Homo sapiens_hsa046121.11447884
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03381195
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99484948
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98280582
50Glutathione metabolism_Homo sapiens_hsa004800.98280453
51mRNA surveillance pathway_Homo sapiens_hsa030150.95312446
52RNA transport_Homo sapiens_hsa030130.94197693
53Circadian rhythm_Homo sapiens_hsa047100.93663747
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93386582
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93317952
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92922171
57Sulfur metabolism_Homo sapiens_hsa009200.89088078
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88343792
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87986901
60Fat digestion and absorption_Homo sapiens_hsa049750.85997385
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85029121
62Hippo signaling pathway_Homo sapiens_hsa043900.81913081
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81385065
64Estrogen signaling pathway_Homo sapiens_hsa049150.79137105
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77037850
66Hedgehog signaling pathway_Homo sapiens_hsa043400.75879975
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.75048361
68Nitrogen metabolism_Homo sapiens_hsa009100.73760197
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73204404
70Adherens junction_Homo sapiens_hsa045200.72682627
71Collecting duct acid secretion_Homo sapiens_hsa049660.72028646
72Steroid biosynthesis_Homo sapiens_hsa001000.71818277
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69182865
74Long-term potentiation_Homo sapiens_hsa047200.68663487
75Chemical carcinogenesis_Homo sapiens_hsa052040.68468741
76Biosynthesis of amino acids_Homo sapiens_hsa012300.68133780
77Fatty acid metabolism_Homo sapiens_hsa012120.67215180
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66902262
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66836415
80Insulin secretion_Homo sapiens_hsa049110.66058606
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64937495
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64356289
83Starch and sucrose metabolism_Homo sapiens_hsa005000.64083929
84Notch signaling pathway_Homo sapiens_hsa043300.63409337
85Axon guidance_Homo sapiens_hsa043600.62184050
86Butanoate metabolism_Homo sapiens_hsa006500.62125270
87Renin-angiotensin system_Homo sapiens_hsa046140.62100387
88Calcium signaling pathway_Homo sapiens_hsa040200.61227242
89Systemic lupus erythematosus_Homo sapiens_hsa053220.60511920
90Taste transduction_Homo sapiens_hsa047420.59851891
91Arginine and proline metabolism_Homo sapiens_hsa003300.59052850
92Thyroid hormone synthesis_Homo sapiens_hsa049180.58329822
93ABC transporters_Homo sapiens_hsa020100.57684558
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56841696
95Arachidonic acid metabolism_Homo sapiens_hsa005900.54788207
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54173237
97Fatty acid degradation_Homo sapiens_hsa000710.53891687
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53192844
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52676818
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52275717
101Synaptic vesicle cycle_Homo sapiens_hsa047210.48355571
102Inositol phosphate metabolism_Homo sapiens_hsa005620.48248119
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.47665158
104Bile secretion_Homo sapiens_hsa049760.46086509
105Melanogenesis_Homo sapiens_hsa049160.45489347
106Choline metabolism in cancer_Homo sapiens_hsa052310.44056553
107Serotonergic synapse_Homo sapiens_hsa047260.40660650
108Metabolic pathways_Homo sapiens_hsa011000.40601782
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39763402
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39166935
111Homologous recombination_Homo sapiens_hsa034400.38259456
112Pyrimidine metabolism_Homo sapiens_hsa002400.38088213
113Gastric acid secretion_Homo sapiens_hsa049710.37638877
114Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37334539
115Tryptophan metabolism_Homo sapiens_hsa003800.36302545
116VEGF signaling pathway_Homo sapiens_hsa043700.35884281
117Protein digestion and absorption_Homo sapiens_hsa049740.33235938
118Endocytosis_Homo sapiens_hsa041440.32708024
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31930245
120Cell cycle_Homo sapiens_hsa041100.31680779
121cAMP signaling pathway_Homo sapiens_hsa040240.31417584
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.31251659
123AMPK signaling pathway_Homo sapiens_hsa041520.31022018
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29655805
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.29561235
126Drug metabolism - other enzymes_Homo sapiens_hsa009830.29467636
127Glutamatergic synapse_Homo sapiens_hsa047240.28894203
128Pancreatic secretion_Homo sapiens_hsa049720.28373252
129Wnt signaling pathway_Homo sapiens_hsa043100.27885547
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27795664
131Salivary secretion_Homo sapiens_hsa049700.27422536
132Olfactory transduction_Homo sapiens_hsa047400.27375012
133GABAergic synapse_Homo sapiens_hsa047270.26629371
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25608332
135Gap junction_Homo sapiens_hsa045400.25030054
136Viral carcinogenesis_Homo sapiens_hsa052030.24915936
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24296577
138Sphingolipid metabolism_Homo sapiens_hsa006000.24158010
139Retinol metabolism_Homo sapiens_hsa008300.23544162
140Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23265694
141Ovarian steroidogenesis_Homo sapiens_hsa049130.23033091
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22853061
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.22555269
144Morphine addiction_Homo sapiens_hsa050320.22094615
145Cocaine addiction_Homo sapiens_hsa050300.21936000
146Circadian entrainment_Homo sapiens_hsa047130.21398957
147Regulation of autophagy_Homo sapiens_hsa041400.21117577
148Dilated cardiomyopathy_Homo sapiens_hsa054140.20771601
149Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20587828
150N-Glycan biosynthesis_Homo sapiens_hsa005100.20355529
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19627760
152Oxidative phosphorylation_Homo sapiens_hsa001900.18320685
153Alcoholism_Homo sapiens_hsa050340.18249457
154Phototransduction_Homo sapiens_hsa047440.18162899
155Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16851615

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