TTC31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.62874413
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33416384
3antigen processing and presentation of endogenous antigen (GO:0019883)4.22537132
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.17609811
5negative thymic T cell selection (GO:0045060)4.01072731
6negative regulation of cell killing (GO:0031342)3.82114168
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.82114168
8negative T cell selection (GO:0043383)3.76426023
9negative regulation of DNA-templated transcription, elongation (GO:0032785)3.62316817
10negative regulation of erythrocyte differentiation (GO:0045647)3.44624303
11negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.39439685
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.39287944
13regulation of gamma-delta T cell activation (GO:0046643)3.38093910
14leukocyte aggregation (GO:0070486)3.35398566
15regulation of gamma-delta T cell differentiation (GO:0045586)3.31877833
16response to interleukin-15 (GO:0070672)3.30217235
17neutrophil activation involved in immune response (GO:0002283)3.28592067
18positive thymic T cell selection (GO:0045059)3.26713078
19detection of bacterium (GO:0016045)3.26121734
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.22907599
21regulation of B cell receptor signaling pathway (GO:0050855)3.19654577
22positive regulation of granulocyte differentiation (GO:0030854)3.13132358
23T cell migration (GO:0072678)3.09812607
24cellular response to interleukin-15 (GO:0071350)3.09121741
25detection of other organism (GO:0098543)3.08212528
26thymic T cell selection (GO:0045061)3.07047853
27Arp2/3 complex-mediated actin nucleation (GO:0034314)3.03756647
28mannose metabolic process (GO:0006013)2.98537187
29NIK/NF-kappaB signaling (GO:0038061)2.98427212
30negative regulation of myeloid cell apoptotic process (GO:0033033)2.98399292
31positive regulation of B cell differentiation (GO:0045579)2.97726370
32positive regulation by symbiont of host defense response (GO:0052509)2.96708794
33modulation by symbiont of host defense response (GO:0052031)2.96708794
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.96708794
35modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.96708794
36positive regulation by organism of defense response of other organism involved in symbiotic interact2.96708794
37modulation by symbiont of host immune response (GO:0052553)2.96708794
38base-excision repair, AP site formation (GO:0006285)2.96022493
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94316016
40COPI coating of Golgi vesicle (GO:0048205)2.94282589
41Golgi transport vesicle coating (GO:0048200)2.94282589
42immunoglobulin mediated immune response (GO:0016064)2.92107570
43negative regulation of phagocytosis (GO:0050765)2.91475365
44negative regulation of fibrinolysis (GO:0051918)2.89199365
45response to type I interferon (GO:0034340)2.80961226
46cellular response to type I interferon (GO:0071357)2.79795284
47type I interferon signaling pathway (GO:0060337)2.79795284
48regulation of B cell differentiation (GO:0045577)2.77955842
49monoubiquitinated protein deubiquitination (GO:0035520)2.74978703
50response to muramyl dipeptide (GO:0032495)2.74412637
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74279500
52T cell selection (GO:0045058)2.73848550
53pinocytosis (GO:0006907)2.73007109
54response to peptidoglycan (GO:0032494)2.72387783
55regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68865872
563-UTR-mediated mRNA stabilization (GO:0070935)2.66324232
57regulation of granulocyte differentiation (GO:0030852)2.64981196
58modulation by virus of host process (GO:0019054)2.64877881
59B cell receptor signaling pathway (GO:0050853)2.63055987
60cellular extravasation (GO:0045123)2.62258992
61negative regulation of innate immune response (GO:0045824)2.61394435
62cellular response to interleukin-4 (GO:0071353)2.61170736
63complement activation, alternative pathway (GO:0006957)2.58402277
64spliceosomal tri-snRNP complex assembly (GO:0000244)2.55732947
65response to interferon-beta (GO:0035456)2.55547456
66actin filament polymerization (GO:0030041)2.52069096
67detection of external biotic stimulus (GO:0098581)2.51135859
68positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.48217927
69myeloid dendritic cell differentiation (GO:0043011)2.47484938
70GDP-mannose metabolic process (GO:0019673)2.46880131
71neutrophil activation (GO:0042119)2.46613512
72regulation of T cell tolerance induction (GO:0002664)2.46396115
73B cell mediated immunity (GO:0019724)2.46116853
74myeloid dendritic cell activation (GO:0001773)2.43088586
75positive regulation of triglyceride lipase activity (GO:0061365)2.41868800
76positive regulation of lipoprotein lipase activity (GO:0051006)2.41868800
77pyrimidine nucleotide catabolic process (GO:0006244)2.39945958
78negative regulation of lymphocyte mediated immunity (GO:0002707)2.37589618
79regulation of myeloid leukocyte mediated immunity (GO:0002886)2.35567172
80plasma lipoprotein particle assembly (GO:0034377)2.34323150
81regulation of fibrinolysis (GO:0051917)2.33614945
82regulation of mast cell degranulation (GO:0043304)2.33296805
83germinal center formation (GO:0002467)2.32795632
84L-phenylalanine catabolic process (GO:0006559)2.31468076
85erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.31468076
86regulation of RIG-I signaling pathway (GO:0039535)2.30324894
87regulation of cholesterol esterification (GO:0010872)2.29169456
88regulation of monocyte differentiation (GO:0045655)2.28385671
89regulation of alpha-beta T cell proliferation (GO:0046640)2.28144868
90poly(A)+ mRNA export from nucleus (GO:0016973)2.28106640
91defense response to protozoan (GO:0042832)2.27755065
92cellular response to interferon-beta (GO:0035458)2.27185362
93L-phenylalanine metabolic process (GO:0006558)2.27083634
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.27083634
95granulocyte activation (GO:0036230)2.26634230
96regulation of necroptotic process (GO:0060544)2.25966330
97glyoxylate metabolic process (GO:0046487)2.25712677
98positive T cell selection (GO:0043368)2.25316209
99response to interleukin-4 (GO:0070670)2.25211907
100antigen receptor-mediated signaling pathway (GO:0050851)2.24059954

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human2.93738735
2VDR_21846776_ChIP-Seq_THP-1_Human2.73227136
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.57894826
4SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16317334
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13571702
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12212260
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05788031
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.01272708
9* CIITA_25753668_ChIP-Seq_RAJI_Human1.94564001
10MAF_26560356_Chip-Seq_TH1_Human1.93115536
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90371112
12ELK3_25401928_ChIP-Seq_HUVEC_Human1.89577534
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88175433
14LXR_22292898_ChIP-Seq_THP-1_Human1.87596950
15UTX_26944678_Chip-Seq_JUKART_Human1.87105431
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85660961
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85166546
18E2F7_22180533_ChIP-Seq_HELA_Human1.83622404
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80780103
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.80350779
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.75696134
22CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.75580597
23MAF_26560356_Chip-Seq_TH2_Human1.75393248
24SPI1_23547873_ChIP-Seq_NB4_Human1.74256375
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73389924
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73126656
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73059275
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67834459
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67811805
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66355692
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66116401
32VDR_24763502_ChIP-Seq_THP-1_Human1.65728647
33* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64024312
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60119414
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.59025019
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.57991084
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57332538
38MYB_26560356_Chip-Seq_TH2_Human1.55152136
39SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54181863
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53902180
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.53600661
42STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53136707
43TCF7_22412390_ChIP-Seq_EML_Mouse1.52353654
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.49038062
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48336470
46MYB_26560356_Chip-Seq_TH1_Human1.46316857
47BCL6_27268052_Chip-Seq_Bcells_Human1.45354248
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44485718
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.41992759
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41834017
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41664062
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41613146
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40046749
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.39988556
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37223447
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35477998
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35082437
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34965795
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.34959333
60SCL_19346495_ChIP-Seq_HPC-7_Human1.34564021
61RXR_22158963_ChIP-Seq_LIVER_Mouse1.34509153
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.33712746
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32831848
64P68_20966046_ChIP-Seq_HELA_Human1.32333727
65IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31838595
66KDM2B_26808549_Chip-Seq_DND41_Human1.31063937
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29370808
68BCOR_27268052_Chip-Seq_Bcells_Human1.29127923
69NCOR1_26117541_ChIP-Seq_K562_Human1.27489239
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25437593
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25011456
72RUNX_20019798_ChIP-Seq_JUKART_Human1.23449245
73SPI1_23127762_ChIP-Seq_K562_Human1.22368175
74* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22142996
75PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21931468
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21561552
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20536506
78RACK7_27058665_Chip-Seq_MCF-7_Human1.20444115
79TFEB_21752829_ChIP-Seq_HELA_Human1.19641401
80VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19241122
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.18929231
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.17884668
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.14174050
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13746046
85GABP_19822575_ChIP-Seq_HepG2_Human1.12987365
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.12845346
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12786373
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12305085
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10684777
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09454640
91CTCF_26484167_Chip-Seq_Bcells_Mouse1.09126647
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08071986
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07750143
94SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07598143
95GATA1_19941827_ChIP-Seq_MEL_Mouse1.07355364
96XRN2_22483619_ChIP-Seq_HELA_Human1.06733599
97THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06633076
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05104464
99FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03505744
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02475894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.76206529
2MP0005058_abnormal_lysosome_morphology3.23411861
3MP0008260_abnormal_autophagy3.02513116
4MP0001835_abnormal_antigen_presentation2.83279166
5MP0003763_abnormal_thymus_physiology2.61547571
6MP0000685_abnormal_immune_system2.50706989
7MP0005671_abnormal_response_to2.42046338
8MP0005360_urolithiasis2.41516955
9MP0001800_abnormal_humoral_immune2.39265873
10MP0005000_abnormal_immune_tolerance2.35737179
11MP0003172_abnormal_lysosome_physiology2.34716679
12MP0005025_abnormal_response_to2.29131169
13MP0002419_abnormal_innate_immunity2.28962172
14MP0001853_heart_inflammation2.22984439
15MP0003646_muscle_fatigue2.15748956
16MP0002723_abnormal_immune_serum2.09242459
17MP0009333_abnormal_splenocyte_physiolog2.04766154
18MP0003724_increased_susceptibility_to2.04597910
19MP0002396_abnormal_hematopoietic_system2.03447382
20MP0003300_gastrointestinal_ulcer2.03182042
21MP0002452_abnormal_antigen_presenting2.01215580
22MP0005387_immune_system_phenotype2.00797762
23MP0001790_abnormal_immune_system2.00797762
24MP0005451_abnormal_body_composition2.00394308
25MP0002420_abnormal_adaptive_immunity1.99553990
26MP0001819_abnormal_immune_cell1.97928645
27MP0009785_altered_susceptibility_to1.89685407
28MP0002398_abnormal_bone_marrow1.86237385
29MP0003303_peritoneal_inflammation1.83208158
30MP0005464_abnormal_platelet_physiology1.75887615
31MP0009278_abnormal_bone_marrow1.75664520
32MP0004185_abnormal_adipocyte_glucose1.72782914
33MP0000716_abnormal_immune_system1.71600309
34MP0001533_abnormal_skeleton_physiology1.67892084
35MP0002722_abnormal_immune_system1.67438245
36MP0000689_abnormal_spleen_morphology1.66959638
37MP0002405_respiratory_system_inflammati1.61383478
38MP0003191_abnormal_cellular_cholesterol1.61223221
39MP0000858_altered_metastatic_potential1.58188123
40MP0010155_abnormal_intestine_physiology1.57877598
41MP0002139_abnormal_hepatobiliary_system1.56087833
42MP0000703_abnormal_thymus_morphology1.54514534
43MP0009840_abnormal_foam_cell1.52636982
44MP0002429_abnormal_blood_cell1.51849769
45MP0002148_abnormal_hypersensitivity_rea1.49769243
46MP0001845_abnormal_inflammatory_respons1.43762115
47MP0005365_abnormal_bile_salt1.39947852
48MP0004947_skin_inflammation1.39926185
49MP0005397_hematopoietic_system_phenotyp1.38196432
50MP0001545_abnormal_hematopoietic_system1.38196432
51MP0002166_altered_tumor_susceptibility1.37499280
52MP0008469_abnormal_protein_level1.35153507
53MP0002132_abnormal_respiratory_system1.29850895
54MP0004381_abnormal_hair_follicle1.18843150
55MP0000490_abnormal_crypts_of1.17398857
56MP0002933_joint_inflammation1.16285766
57MP0003656_abnormal_erythrocyte_physiolo1.15555405
58MP0006082_CNS_inflammation1.10714334
59MP0000609_abnormal_liver_physiology1.09424500
60MP0009764_decreased_sensitivity_to1.08208369
61MP0005666_abnormal_adipose_tissue1.07445927
62MP0003111_abnormal_nucleus_morphology1.06501136
63MP0009763_increased_sensitivity_to1.03460665
64MP0003866_abnormal_defecation1.01875914
65MP0010329_abnormal_lipoprotein_level1.00135108
66MP0003705_abnormal_hypodermis_morpholog0.99840268
67MP0001849_ear_inflammation0.98205295
68MP0005076_abnormal_cell_differentiation0.98040725
69MP0001764_abnormal_homeostasis0.97247947
70MP0002998_abnormal_bone_remodeling0.97083556
71MP0001666_abnormal_nutrient_absorption0.95517318
72MP0005075_abnormal_melanosome_morpholog0.95155721
73MP0009384_cardiac_valve_regurgitation0.94195082
74MP0002019_abnormal_tumor_incidence0.93951030
75MP0001873_stomach_inflammation0.93518599
76MP0009765_abnormal_xenobiotic_induced0.88527147
77MP0000465_gastrointestinal_hemorrhage0.84981485
78MP0001986_abnormal_taste_sensitivity0.83400332
79MP0009115_abnormal_fat_cell0.82591585
80MP0005670_abnormal_white_adipose0.82014745
81MP0002006_tumorigenesis0.81896424
82MP0003693_abnormal_embryo_hatching0.81452582
83MP0000343_altered_response_to0.80505618
84MP0002138_abnormal_hepatobiliary_system0.78860693
85MP0002009_preneoplasia0.78243985
86MP0005584_abnormal_enzyme/coenzyme_acti0.77945634
87MP0003136_yellow_coat_color0.77778559
88MP0004808_abnormal_hematopoietic_stem0.77426744
89MP0000604_amyloidosis0.76311478
90MP0005408_hypopigmentation0.76252301
91MP0005319_abnormal_enzyme/_coenzyme0.76106708
92MP0001270_distended_abdomen0.75563560
93MP0005085_abnormal_gallbladder_physiolo0.74262148
94MP0000598_abnormal_liver_morphology0.73632039
95MP0005390_skeleton_phenotype0.73217936
96MP0002837_dystrophic_cardiac_calcinosis0.71925914
97MP0005023_abnormal_wound_healing0.71084114
98MP0002089_abnormal_postnatal_growth/wei0.70350287
99MP0003183_abnormal_peptide_metabolism0.70287881
100MP0001851_eye_inflammation0.70245980

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)5.58977131
2Eczematoid dermatitis (HP:0000976)4.46683434
3Deep venous thrombosis (HP:0002625)3.70441304
4Systemic lupus erythematosus (HP:0002725)3.56382533
5Recurrent abscess formation (HP:0002722)3.51309282
6Elevated erythrocyte sedimentation rate (HP:0003565)3.35145060
7Myositis (HP:0100614)3.29581875
8Colitis (HP:0002583)3.21790799
9Agammaglobulinemia (HP:0004432)3.15725521
10Recurrent bacterial skin infections (HP:0005406)3.02453460
11Recurrent fungal infections (HP:0002841)3.01858887
12Panhypogammaglobulinemia (HP:0003139)2.92752443
13Pustule (HP:0200039)2.84879555
14Dysostosis multiplex (HP:0000943)2.84268712
15Abnormality of macrophages (HP:0004311)2.81283206
16Recurrent gram-negative bacterial infections (HP:0005420)2.80757720
17Gastrointestinal inflammation (HP:0004386)2.78016235
18Mediastinal lymphadenopathy (HP:0100721)2.74744787
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.74054521
20Increased IgM level (HP:0003496)2.72760724
21Hemorrhage of the eye (HP:0011885)2.71815069
22Recurrent viral infections (HP:0004429)2.71006195
23Abnormality of polysaccharide metabolism (HP:0011012)2.70976382
24Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70976382
25Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70976382
26Chronic mucocutaneous candidiasis (HP:0002728)2.67597076
27Recurrent cutaneous fungal infections (HP:0011370)2.67597076
28Purpura (HP:0000979)2.67487537
29Urinary glycosaminoglycan excretion (HP:0003541)2.67417791
30Mucopolysacchariduria (HP:0008155)2.67417791
31Recurrent skin infections (HP:0001581)2.62800068
32Increased IgE level (HP:0003212)2.61661707
33Gastrointestinal infarctions (HP:0005244)2.61223542
34Inflammation of the large intestine (HP:0002037)2.60408140
35Chronic obstructive pulmonary disease (HP:0006510)2.59679150
36Obstructive lung disease (HP:0006536)2.59679150
37Meningitis (HP:0001287)2.57396222
38Complement deficiency (HP:0004431)2.55473324
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.53674603
40Orchitis (HP:0100796)2.51424399
41Abnormality of complement system (HP:0005339)2.51198203
42Stomatitis (HP:0010280)2.48848127
43Seborrheic dermatitis (HP:0001051)2.46681723
44Abnormality of pyrimidine metabolism (HP:0004353)2.45920658
45Microvesicular hepatic steatosis (HP:0001414)2.39151337
46Epistaxis (HP:0000421)2.38402463
47Spontaneous hematomas (HP:0007420)2.37370683
48Joint hemorrhage (HP:0005261)2.36970071
49Vasculitis (HP:0002633)2.35301648
50Prolonged bleeding time (HP:0003010)2.33023000
51Cellulitis (HP:0100658)2.32549683
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32253366
53Abnormality of T cell physiology (HP:0011840)2.31701692
54Ragged-red muscle fibers (HP:0003200)2.29765565
55Abnormality of T cells (HP:0002843)2.29738540
56Gingival bleeding (HP:0000225)2.29576711
57Hepatosplenomegaly (HP:0001433)2.28218603
58IgG deficiency (HP:0004315)2.27607932
59Prolonged partial thromboplastin time (HP:0003645)2.24541431
60Gingivitis (HP:0000230)2.21891026
61Lymphopenia (HP:0001888)2.21591804
62Encephalitis (HP:0002383)2.19189580
63Vertebral compression fractures (HP:0002953)2.18317381
64IgM deficiency (HP:0002850)2.18218940
65Increased serum ferritin (HP:0003281)2.17689147
66Granulocytopenia (HP:0001913)2.13428756
67Petechiae (HP:0000967)2.12854582
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.12059369
69Glomerulonephritis (HP:0000099)2.10995370
70Acute hepatic failure (HP:0006554)2.10485469
71Hypertensive crisis (HP:0100735)2.08420397
72Xanthomatosis (HP:0000991)2.07207509
73Optic neuritis (HP:0100653)2.05762010
74Retrobulbar optic neuritis (HP:0100654)2.05762010
75T lymphocytopenia (HP:0005403)2.04014100
76Viral hepatitis (HP:0006562)2.02734038
77Cervical subluxation (HP:0003308)2.02586127
78Small epiphyses (HP:0010585)2.02047835
79Gastrointestinal stroma tumor (HP:0100723)2.00756622
80Abnormality of T cell number (HP:0011839)1.94764292
81Hypergammaglobulinemia (HP:0010702)1.93869943
82Biconcave vertebral bodies (HP:0004586)1.91263779
83Hyperglycinemia (HP:0002154)1.91176690
84Increased cerebral lipofuscin (HP:0011813)1.90450420
85Pulmonary infiltrates (HP:0002113)1.90244710
86Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86394538
87Dicarboxylic aciduria (HP:0003215)1.86394538
88Abnormality of the peritoneum (HP:0002585)1.85988837
89Vacuolated lymphocytes (HP:0001922)1.85132605
90Interstitial pulmonary disease (HP:0006530)1.84818662
91Reticulocytosis (HP:0001923)1.83791415
92Abnormality of iron homeostasis (HP:0011031)1.82284336
93Joint stiffness (HP:0001387)1.81502139
94Verrucae (HP:0200043)1.80904598
95Papilloma (HP:0012740)1.80904598
96Abnormal gallbladder physiology (HP:0012438)1.79610741
97Cholecystitis (HP:0001082)1.79610741
98Hepatitis (HP:0012115)1.79331998
99Emphysema (HP:0002097)1.79015196
100Urticaria (HP:0001025)1.77691348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.88118322
2MAP4K13.43409795
3FGFR42.86656959
4MAP3K142.76103865
5TYK22.71559699
6PRPF4B2.47444761
7MAP3K132.40825652
8TRIB32.40771428
9GRK62.26720845
10RIPK42.10244143
11TESK22.10238530
12IRAK42.04885007
13MAP2K31.98157546
14TBK11.85026763
15SMG11.82912419
16CDK121.80872510
17TXK1.80037127
18SIK21.79871361
19SIK31.77985325
20SIK11.74616787
21EPHB11.68894319
22ZAP701.62963302
23MAP3K111.58625026
24JAK31.53379310
25JAK11.53110293
26BTK1.49939108
27BLK1.46147526
28FGFR31.42369310
29CSF1R1.35085264
30MAP3K101.33995143
31MAP2K21.32246998
32BCKDK1.28257730
33IKBKE1.27730430
34SYK1.19197314
35KDR1.16946442
36CDK41.16898191
37CSK1.16450910
38ITK1.15783745
39IKBKB1.13622860
40FES1.11463566
41IRAK31.11001538
42PRKD21.07708321
43TNK21.07337201
44EPHA31.00602581
45ICK0.99974786
46PKN20.96305856
47HCK0.96298260
48LCK0.96111913
49IRAK10.96017256
50KIT0.94901346
51MAPK110.92624948
52LYN0.91963758
53FGR0.91794415
54MAP3K70.87000265
55MARK30.86030962
56RPS6KA40.81876697
57STK100.80289061
58VRK20.79852700
59TEC0.79793647
60TAOK20.78424219
61LRRK20.78288777
62NLK0.78241036
63CDC42BPA0.77992586
64MARK20.74314853
65PTK60.72801480
66MAP3K10.72730972
67NME20.70162175
68MAPKAPK20.67672455
69NEK90.66823747
70CDK70.62739588
71MAP3K30.61322859
72MAPK70.61090775
73CDK90.60836901
74DYRK1B0.59576894
75MELK0.58088902
76JAK20.57461568
77BMX0.57282381
78PIM20.56088316
79MAPKAPK30.53994636
80EEF2K0.52473104
81RPS6KL10.51608262
82RPS6KC10.51608262
83CDK60.51342718
84TAOK30.50375364
85PRKG20.50003233
86PDPK10.49984396
87MATK0.48347454
88PRKCQ0.48137798
89TAOK10.47525398
90CHUK0.47012618
91DDR20.46106125
92NEK20.45934100
93IRAK20.44114704
94PIM10.42850126
95ATR0.41426942
96PAK40.40505503
97SCYL20.40218147
98PDGFRA0.39421014
99RET0.37348568
100TESK10.37170379

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.58939138
2Primary immunodeficiency_Homo sapiens_hsa053403.05556069
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.50314551
4Staphylococcus aureus infection_Homo sapiens_hsa051502.45931965
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.22078072
6Base excision repair_Homo sapiens_hsa034102.15395777
7B cell receptor signaling pathway_Homo sapiens_hsa046621.95086191
8Leishmaniasis_Homo sapiens_hsa051401.90833920
9Complement and coagulation cascades_Homo sapiens_hsa046101.88940922
10Osteoclast differentiation_Homo sapiens_hsa043801.85777957
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.80060726
12Allograft rejection_Homo sapiens_hsa053301.78246380
13Herpes simplex infection_Homo sapiens_hsa051681.75896243
14Graft-versus-host disease_Homo sapiens_hsa053321.71078444
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70460178
16Antigen processing and presentation_Homo sapiens_hsa046121.63788993
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58067487
18Acute myeloid leukemia_Homo sapiens_hsa052211.55745382
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.53929593
20Autoimmune thyroid disease_Homo sapiens_hsa053201.49127129
21Measles_Homo sapiens_hsa051621.42754165
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.38292447
23T cell receptor signaling pathway_Homo sapiens_hsa046601.36878489
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.36379964
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36260496
26Hematopoietic cell lineage_Homo sapiens_hsa046401.35114487
27DNA replication_Homo sapiens_hsa030301.34401878
28Influenza A_Homo sapiens_hsa051641.29701041
29Fructose and mannose metabolism_Homo sapiens_hsa000511.22706572
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21059508
31Adipocytokine signaling pathway_Homo sapiens_hsa049201.19974252
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19375161
33Malaria_Homo sapiens_hsa051441.16720583
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16034415
35Hepatitis B_Homo sapiens_hsa051611.11000298
36Biosynthesis of amino acids_Homo sapiens_hsa012301.10133266
37Galactose metabolism_Homo sapiens_hsa000521.09626927
38Viral myocarditis_Homo sapiens_hsa054161.09348114
39Asthma_Homo sapiens_hsa053101.06413374
40Shigellosis_Homo sapiens_hsa051311.05270698
41Toxoplasmosis_Homo sapiens_hsa051451.04282936
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04215496
43Fatty acid degradation_Homo sapiens_hsa000711.03052684
44Lysosome_Homo sapiens_hsa041421.02608974
45Tuberculosis_Homo sapiens_hsa051521.01268129
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97537967
47Jak-STAT signaling pathway_Homo sapiens_hsa046300.95593235
48TNF signaling pathway_Homo sapiens_hsa046680.93738252
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93580874
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92444578
51Hepatitis C_Homo sapiens_hsa051600.92204942
52Pertussis_Homo sapiens_hsa051330.91628668
53Pentose phosphate pathway_Homo sapiens_hsa000300.90679618
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88269929
55HTLV-I infection_Homo sapiens_hsa051660.87579268
56Chronic myeloid leukemia_Homo sapiens_hsa052200.86119961
57Spliceosome_Homo sapiens_hsa030400.85276382
58Insulin resistance_Homo sapiens_hsa049310.84993316
59Apoptosis_Homo sapiens_hsa042100.84675576
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.82786933
61Epstein-Barr virus infection_Homo sapiens_hsa051690.80896437
62Type I diabetes mellitus_Homo sapiens_hsa049400.80673701
63Pancreatic cancer_Homo sapiens_hsa052120.77662748
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76212149
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76059937
66Non-small cell lung cancer_Homo sapiens_hsa052230.74205189
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71815308
68Notch signaling pathway_Homo sapiens_hsa043300.71572714
69Chemokine signaling pathway_Homo sapiens_hsa040620.70900796
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70877811
71Viral carcinogenesis_Homo sapiens_hsa052030.66477274
72Lysine degradation_Homo sapiens_hsa003100.66386808
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65712944
74Carbon metabolism_Homo sapiens_hsa012000.65424950
75N-Glycan biosynthesis_Homo sapiens_hsa005100.64484954
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59078479
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57822470
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.56885666
79Glycerolipid metabolism_Homo sapiens_hsa005610.56108758
80PPAR signaling pathway_Homo sapiens_hsa033200.55889383
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.55395496
82Renin-angiotensin system_Homo sapiens_hsa046140.54703387
83Phenylalanine metabolism_Homo sapiens_hsa003600.54203192
84Fatty acid metabolism_Homo sapiens_hsa012120.52406385
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51957998
86Vitamin digestion and absorption_Homo sapiens_hsa049770.51840606
87One carbon pool by folate_Homo sapiens_hsa006700.51766326
88Endocytosis_Homo sapiens_hsa041440.50906167
89Sulfur relay system_Homo sapiens_hsa041220.48968603
90Peroxisome_Homo sapiens_hsa041460.47575662
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47214426
92Phagosome_Homo sapiens_hsa041450.44179205
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43979117
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.43346136
95ABC transporters_Homo sapiens_hsa020100.42453385
96Legionellosis_Homo sapiens_hsa051340.41399624
97Retinol metabolism_Homo sapiens_hsa008300.39646180
98Small cell lung cancer_Homo sapiens_hsa052220.36735199
99Histidine metabolism_Homo sapiens_hsa003400.34629362
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33250826

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