TTC37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.94664492
2nuclear pore organization (GO:0006999)6.64534779
3pore complex assembly (GO:0046931)4.97411876
4folic acid-containing compound biosynthetic process (GO:0009396)4.76367392
5mitotic sister chromatid cohesion (GO:0007064)4.69642006
6protein localization to kinetochore (GO:0034501)4.69012547
7mitotic chromosome condensation (GO:0007076)4.47940241
8mitotic nuclear envelope disassembly (GO:0007077)4.33189092
9regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.32828068
10regulation of mitotic spindle organization (GO:0060236)4.17023570
11nuclear envelope disassembly (GO:0051081)4.12135140
12membrane disassembly (GO:0030397)4.12135140
13monoubiquitinated protein deubiquitination (GO:0035520)3.91454577
14DNA unwinding involved in DNA replication (GO:0006268)3.91020205
15mitotic metaphase plate congression (GO:0007080)3.84611144
16DNA geometric change (GO:0032392)3.84176349
17regulation of spindle organization (GO:0090224)3.83561812
18DNA duplex unwinding (GO:0032508)3.80246655
19COPII vesicle coating (GO:0048208)3.74947616
20sister chromatid segregation (GO:0000819)3.67968960
21protein localization to chromosome, centromeric region (GO:0071459)3.66435947
22metaphase plate congression (GO:0051310)3.59389370
23histone H2A monoubiquitination (GO:0035518)3.43883950
24regulation of sister chromatid cohesion (GO:0007063)3.39715837
25IMP biosynthetic process (GO:0006188)3.38228145
26negative regulation of DNA repair (GO:0045738)3.32546242
27regulation of translational fidelity (GO:0006450)3.32488755
28establishment of chromosome localization (GO:0051303)3.32383998
29protein prenylation (GO:0018342)3.31762884
30prenylation (GO:0097354)3.31762884
31kinetochore organization (GO:0051383)3.26016939
32tetrahydrofolate metabolic process (GO:0046653)3.23292561
33positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20703893
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20703893
35positive regulation of mitotic sister chromatid separation (GO:1901970)3.20703893
36regulation of RNA export from nucleus (GO:0046831)3.19788979
37meiotic chromosome segregation (GO:0045132)3.17881706
38mitotic sister chromatid segregation (GO:0000070)3.16790586
39positive regulation of protein autophosphorylation (GO:0031954)3.14806732
40lactate metabolic process (GO:0006089)3.13754064
41heterochromatin organization (GO:0070828)3.13665899
42nuclear envelope organization (GO:0006998)3.12629558
43Golgi transport vesicle coating (GO:0048200)3.12046393
44COPI coating of Golgi vesicle (GO:0048205)3.12046393
45regulation of histone H3-K9 methylation (GO:0051570)3.11018563
46IMP metabolic process (GO:0046040)3.09767756
47chromatin assembly (GO:0031497)3.06194516
48regulation of DNA endoreduplication (GO:0032875)3.05623245
49DNA replication-dependent nucleosome organization (GO:0034723)3.04004390
50DNA replication-dependent nucleosome assembly (GO:0006335)3.04004390
51regulation of translational termination (GO:0006449)3.03462746
52DNA topological change (GO:0006265)3.02197180
53DNA conformation change (GO:0071103)3.01476819
54negative regulation of histone methylation (GO:0031061)2.98627541
55cytoplasmic mRNA processing body assembly (GO:0033962)2.95289516
56dosage compensation (GO:0007549)2.95083390
57paraxial mesoderm development (GO:0048339)2.94861509
58double-strand break repair via nonhomologous end joining (GO:0006303)2.94468578
59non-recombinational repair (GO:0000726)2.94468578
60sister chromatid cohesion (GO:0007062)2.94245543
61glucocorticoid receptor signaling pathway (GO:0042921)2.94121576
62positive regulation of glycolytic process (GO:0045821)2.92692538
63regulation of centrosome cycle (GO:0046605)2.92393199
64negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.92004649
65regulation of centriole replication (GO:0046599)2.89921243
66NLS-bearing protein import into nucleus (GO:0006607)2.85657389
67positive regulation of muscle hypertrophy (GO:0014742)2.84802679
68positive regulation of cardiac muscle hypertrophy (GO:0010613)2.84802679
69nucleobase biosynthetic process (GO:0046112)2.83274822
70regulation of transforming growth factor beta2 production (GO:0032909)2.83088897
71regulation of posttranscriptional gene silencing (GO:0060147)2.81889142
72regulation of gene silencing by miRNA (GO:0060964)2.81889142
73regulation of gene silencing by RNA (GO:0060966)2.81889142
74pre-miRNA processing (GO:0031054)2.81368458
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.80616989
76sequestering of extracellular ligand from receptor (GO:0035581)2.79306661
77spindle assembly involved in mitosis (GO:0090307)2.75965503
78regulation of centrosome duplication (GO:0010824)2.73934132
79nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.73845523
80protein K6-linked ubiquitination (GO:0085020)2.73696671
81positive regulation of chromosome segregation (GO:0051984)2.71669549
82chromatin assembly or disassembly (GO:0006333)2.71325748
83chromosome condensation (GO:0030261)2.69610169
84negative regulation of cell cycle G2/M phase transition (GO:1902750)2.68449860
85corticosteroid receptor signaling pathway (GO:0031958)2.67427590
86retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67218808
87response to UV-C (GO:0010225)2.66749144
88microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.66138119
89negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.65262841
90regulation of nucleobase-containing compound transport (GO:0032239)2.63192754
91chondrocyte proliferation (GO:0035988)2.62408497
92somatic diversification of immune receptors via somatic mutation (GO:0002566)2.62395668
93somatic hypermutation of immunoglobulin genes (GO:0016446)2.62395668
94histone mRNA catabolic process (GO:0071044)2.62105417
95artery development (GO:0060840)2.60846163
96protein localization to chromosome (GO:0034502)2.60394675
97attachment of spindle microtubules to kinetochore (GO:0008608)2.60165353
98protein export from nucleus (GO:0006611)2.59582716
99histone-serine phosphorylation (GO:0035404)2.59383421
100chromosome segregation (GO:0007059)2.57623650
101UDP-N-acetylglucosamine metabolic process (GO:0006047)2.56984443
102mRNA transport (GO:0051028)2.55697686
103negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.55578241
104gastrulation with mouth forming second (GO:0001702)2.54866388
105replicative senescence (GO:0090399)2.53083647
106spindle checkpoint (GO:0031577)2.51564385
107anterior/posterior axis specification, embryo (GO:0008595)2.51476220
108determination of adult lifespan (GO:0008340)2.49244370
109spliceosomal tri-snRNP complex assembly (GO:0000244)2.48792533
110regulation of helicase activity (GO:0051095)2.47526615
111chromatin remodeling at centromere (GO:0031055)2.47478478
112monosaccharide transport (GO:0015749)2.46042408
113DNA packaging (GO:0006323)2.45792614
114regulation of glucokinase activity (GO:0033131)2.44709459
115regulation of hexokinase activity (GO:1903299)2.44709459
116gene silencing by RNA (GO:0031047)2.43670479
117positive regulation of protein import into nucleus, translocation (GO:0033160)2.42705418
118translesion synthesis (GO:0019985)2.42298620
119regulation of chromosome segregation (GO:0051983)2.41820938
120negative regulation of keratinocyte proliferation (GO:0010839)2.41792916
121regulation of Rac protein signal transduction (GO:0035020)2.40243167
122collagen fibril organization (GO:0030199)2.40112163
123genitalia morphogenesis (GO:0035112)2.40110787
124establishment of nucleus localization (GO:0040023)2.40076061
125positive regulation of histone H3-K4 methylation (GO:0051571)2.40020979
126negative chemotaxis (GO:0050919)2.39108141
127negative regulation of hormone biosynthetic process (GO:0032353)2.38816631
128Golgi to endosome transport (GO:0006895)2.36353875
129positive regulation of hormone biosynthetic process (GO:0046886)2.33744746
130establishment of protein localization to Golgi (GO:0072600)2.33573660
131protein targeting to Golgi (GO:0000042)2.33096604
132embryonic foregut morphogenesis (GO:0048617)2.32855737
133pericardium development (GO:0060039)2.29418308
134intraciliary transport (GO:0042073)2.27879150
135lipid particle organization (GO:0034389)2.26546201
136regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.25570497
137Leydig cell differentiation (GO:0033327)2.25380211
138DNA double-strand break processing (GO:0000729)2.24774896
139vesicle coating (GO:0006901)2.24485232
140response to X-ray (GO:0010165)2.19984607
141midgut development (GO:0007494)2.19277788
142dorsal/ventral axis specification (GO:0009950)2.18592892
143hippo signaling (GO:0035329)2.18374723
144negative regulation of axon extension involved in axon guidance (GO:0048843)2.18216902
145protein localization to cell surface (GO:0034394)2.17231707
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.16713536
147embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15004217
148response to pheromone (GO:0019236)2.14707327
149blood vessel maturation (GO:0001955)2.14378424
150nucleus localization (GO:0051647)2.12396954
151lymphangiogenesis (GO:0001946)2.10569844
152regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.10261486
153synapsis (GO:0007129)2.09228019
154acrosome assembly (GO:0001675)2.09137115
155intra-Golgi vesicle-mediated transport (GO:0006891)2.09135870
156regulation of steroid hormone biosynthetic process (GO:0090030)2.06710329
157microtubule anchoring (GO:0034453)2.06641026
158morphogenesis of an epithelial sheet (GO:0002011)2.04643125
159phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.03127388
160regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.01361660
161negative regulation of axon guidance (GO:1902668)2.00843370
162regulation of keratinocyte proliferation (GO:0010837)2.00455277
163fibroblast migration (GO:0010761)1.99439525
164resolution of meiotic recombination intermediates (GO:0000712)1.99142611
165regulation of hormone biosynthetic process (GO:0046885)1.98790052
166fatty acid homeostasis (GO:0055089)1.97887494
167negative regulation of hormone metabolic process (GO:0032351)1.97783342
168regulation of secondary heart field cardioblast proliferation (GO:0003266)1.97159316
169regulation of cardioblast proliferation (GO:0003264)1.97159316
170mesenchymal cell differentiation (GO:0048762)1.96500820
171ether lipid metabolic process (GO:0046485)1.96270941
172regulation of axon extension involved in axon guidance (GO:0048841)1.95973782
173regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.95932892
174keratinocyte development (GO:0003334)1.95449372
175early endosome to late endosome transport (GO:0045022)1.94671850
176regulation of type B pancreatic cell apoptotic process (GO:2000674)1.93460794
177regulation of glucocorticoid metabolic process (GO:0031943)1.93034883
178phospholipid translocation (GO:0045332)1.91652606
179lipid translocation (GO:0034204)1.91652606
180negative regulation of fibroblast apoptotic process (GO:2000270)1.91448679

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.25214723
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80261290
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71290612
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.52515894
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.39097955
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.14328696
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04636168
8POU3F2_20337985_ChIP-ChIP_501MEL_Human3.03455726
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75068207
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58177626
11GBX2_23144817_ChIP-Seq_PC3_Human2.57005713
12FUS_26573619_Chip-Seq_HEK293_Human2.53868831
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43180247
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.39065626
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.30977588
16AR_21909140_ChIP-Seq_LNCAP_Human2.25326602
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20036364
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.19943068
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.04728411
20CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00211133
21E2F7_22180533_ChIP-Seq_HELA_Human10.7567902
22TAF15_26573619_Chip-Seq_HEK293_Human1.98078784
23EWS_26573619_Chip-Seq_HEK293_Human1.97244913
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.96507239
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96366898
26P300_19829295_ChIP-Seq_ESCs_Human1.89052463
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.85325457
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.84214978
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81986590
30SMAD4_21799915_ChIP-Seq_A2780_Human1.79082429
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77810520
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.77749225
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77165198
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.72099966
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71999450
36HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71223164
37IGF1R_20145208_ChIP-Seq_DFB_Human1.69989647
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67920283
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64202493
40TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.62882906
41MYC_22102868_ChIP-Seq_BL_Human1.62055874
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60926812
43RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.60181214
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56841903
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56639762
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54049981
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.53608620
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52552246
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52118249
50ZNF274_21170338_ChIP-Seq_K562_Hela1.51192765
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49748032
52GATA1_22025678_ChIP-Seq_K562_Human1.49245688
53ELK1_19687146_ChIP-ChIP_HELA_Human1.48975631
54STAT3_23295773_ChIP-Seq_U87_Human1.48416181
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.48330951
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47411758
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.47283645
58BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46464040
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.46380866
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46170317
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.45552618
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.44310346
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43862366
64CLOCK_20551151_ChIP-Seq_293T_Human1.43855375
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43577047
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43577047
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41715100
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39916585
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34569069
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33863820
71* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33589896
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32878193
73* BRD4_25478319_ChIP-Seq_HGPS_Human1.32345419
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.31452682
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30884421
76TP53_18474530_ChIP-ChIP_U2OS_Human1.28509752
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28010756
78TCF4_23295773_ChIP-Seq_U87_Human1.27796773
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.27627653
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27000083
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26467098
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25122997
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24669531
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23311702
85CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23149656
86CJUN_26792858_Chip-Seq_BT549_Human1.22630130
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21226644
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20529078
89P53_22387025_ChIP-Seq_ESCs_Mouse1.19693308
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19609268
91CMYC_18555785_Chip-Seq_ESCs_Mouse1.18628539
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.17959531
93SOX9_26525672_Chip-Seq_HEART_Mouse1.17535679
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17327557
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.16909893
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16760167
97CBP_20019798_ChIP-Seq_JUKART_Human1.16760167
98AR_25329375_ChIP-Seq_VCAP_Human1.16672973
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15505469
100CIITA_25753668_ChIP-Seq_RAJI_Human1.14843157
101* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14535598
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13364099
103SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12592651
104AHR_22903824_ChIP-Seq_MCF-7_Human1.12110773
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11697989
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11660002
107TFEB_21752829_ChIP-Seq_HELA_Human1.10625893
108ER_23166858_ChIP-Seq_MCF-7_Human1.10517304
109CDX2_22108803_ChIP-Seq_LS180_Human1.10129726
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.09144845
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08374974
112TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08369409
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08127939
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.07887876
115KDM5A_27292631_Chip-Seq_BREAST_Human1.07877663
116FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06669525
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05992368
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05871210
119TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05332133
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04789979
121NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04161009
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.04028370
123YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02366122
124SOX2_21211035_ChIP-Seq_LN229_Gbm1.02361596
125P300_18555785_Chip-Seq_ESCs_Mouse1.02337689
126FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02288248
127STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.02269953
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.01486358
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00959215
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00842523
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99949049
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99949049
133JUN_21703547_ChIP-Seq_K562_Human0.98925288
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98692591
135POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96534381
136TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96156490
137ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95385618
138KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93382446
139PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93271620
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.92783247
141TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91935407
142CHD1_26751641_Chip-Seq_LNCaP_Human0.91258663
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89952578
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.89542878
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88972133
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.88019246
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87998091
148EGR1_23403033_ChIP-Seq_LIVER_Mouse0.87699945
149KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.87547196
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87527768
151IRF8_22096565_ChIP-ChIP_GC-B_Human0.87305762
152MYB_26560356_Chip-Seq_TH1_Human0.86794317
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.86700941
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.86657254
155CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86436656
156XRN2_22483619_ChIP-Seq_HELA_Human0.84411116
157FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82500367
158BRD4_27068464_Chip-Seq_AML-cells_Mouse0.82441150
159VDR_23849224_ChIP-Seq_CD4+_Human0.81297217
160CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.79846662
161* FOXP3_21729870_ChIP-Seq_TREG_Human0.79416547
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.78661377
163MYB_21317192_ChIP-Seq_ERMYB_Mouse0.78639268
164GATA6_25053715_ChIP-Seq_YYC3_Human0.78274821
165CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.77970303
166SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.77869386
167MYB_26560356_Chip-Seq_TH2_Human0.77753098
168CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.77362984
169MYC_18358816_ChIP-ChIP_MESCs_Mouse0.76477920
170SOX2_18555785_ChIP-Seq_MESCs_Mouse0.75735502
171TP53_16413492_ChIP-PET_HCT116_Human0.75524275
172SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74408188
173RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73380592
174CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72909783
175E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.72180019
176ATF3_27146783_Chip-Seq_COLON_Human0.71586356
177CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69599777
178MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.69161637
179EST1_17652178_ChIP-ChIP_JURKAT_Human0.68920385
180E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68904476

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.65685112
2MP0010352_gastrointestinal_tract_polyps3.38445426
3MP0003693_abnormal_embryo_hatching2.94489401
4MP0000569_abnormal_digit_pigmentation2.74344153
5MP0010094_abnormal_chromosome_stability2.72142414
6MP0010307_abnormal_tumor_latency2.68243949
7MP0008057_abnormal_DNA_replication2.65234242
8MP0008438_abnormal_cutaneous_collagen2.59637083
9MP0003111_abnormal_nucleus_morphology2.41901170
10MP0003077_abnormal_cell_cycle2.40433392
11MP0009780_abnormal_chondrocyte_physiolo2.39405722
12MP0004957_abnormal_blastocyst_morpholog2.33277500
13MP0006054_spinal_hemorrhage2.32481663
14MP0002877_abnormal_melanocyte_morpholog2.29450542
15MP0000013_abnormal_adipose_tissue2.16276408
16MP0003123_paternal_imprinting2.13232764
17MP0003566_abnormal_cell_adhesion2.06947904
18MP0005076_abnormal_cell_differentiation2.02664494
19MP0008007_abnormal_cellular_replicative1.86217129
20MP0010234_abnormal_vibrissa_follicle1.83044884
21MP0002009_preneoplasia1.81582310
22MP0009053_abnormal_anal_canal1.79543565
23MP0003950_abnormal_plasma_membrane1.78261861
24MP0001730_embryonic_growth_arrest1.68692893
25MP0000350_abnormal_cell_proliferation1.66648476
26MP0003806_abnormal_nucleotide_metabolis1.65877479
27MP0003283_abnormal_digestive_organ1.65483625
28MP0004197_abnormal_fetal_growth/weight/1.64630936
29MP0005275_abnormal_skin_tensile1.63426735
30MP0002396_abnormal_hematopoietic_system1.62218631
31MP0001915_intracranial_hemorrhage1.60823590
32MP0005023_abnormal_wound_healing1.60756660
33MP0001661_extended_life_span1.54546059
34MP0005171_absent_coat_pigmentation1.54365778
35MP0010678_abnormal_skin_adnexa1.51357081
36MP0001672_abnormal_embryogenesis/_devel1.51250747
37MP0005380_embryogenesis_phenotype1.51250747
38MP0004134_abnormal_chest_morphology1.47629105
39MP0003121_genomic_imprinting1.47130169
40MP0002086_abnormal_extraembryonic_tissu1.46849198
41MP0002102_abnormal_ear_morphology1.46097633
42MP0004264_abnormal_extraembryonic_tissu1.45091264
43MP0003890_abnormal_embryonic-extraembry1.44554698
44MP0003300_gastrointestinal_ulcer1.43129824
45MP0003984_embryonic_growth_retardation1.40799076
46MP0002088_abnormal_embryonic_growth/wei1.39509164
47MP0002084_abnormal_developmental_patter1.39273793
48MP0002938_white_spotting1.38687736
49MP0005367_renal/urinary_system_phenotyp1.38556239
50MP0000516_abnormal_urinary_system1.38556239
51MP0003385_abnormal_body_wall1.37244796
52MP0004145_abnormal_muscle_electrophysio1.36627907
53MP0008058_abnormal_DNA_repair1.35487917
54MP0004185_abnormal_adipocyte_glucose1.34613328
55MP0001697_abnormal_embryo_size1.27581272
56MP0004215_abnormal_myocardial_fiber1.26451207
57MP0009672_abnormal_birth_weight1.26419025
58MP0000003_abnormal_adipose_tissue1.24720203
59MP0010368_abnormal_lymphatic_system1.23572627
60MP0004808_abnormal_hematopoietic_stem1.23094201
61MP0005408_hypopigmentation1.21706928
62MP0004084_abnormal_cardiac_muscle1.21388118
63MP0003252_abnormal_bile_duct1.21142019
64MP0000383_abnormal_hair_follicle1.19742330
65MP0002060_abnormal_skin_morphology1.18544245
66MP0002233_abnormal_nose_morphology1.17568712
67MP0005187_abnormal_penis_morphology1.16625213
68MP0002085_abnormal_embryonic_tissue1.14513608
69MP0002139_abnormal_hepatobiliary_system1.14006866
70MP0000733_abnormal_muscle_development1.12670012
71MP0009703_decreased_birth_body1.12276482
72MP0003091_abnormal_cell_migration1.11775455
73MP0005220_abnormal_exocrine_pancreas1.11137862
74MP0002080_prenatal_lethality1.09975001
75MP0003937_abnormal_limbs/digits/tail_de1.09586691
76MP0006072_abnormal_retinal_apoptosis1.09417643
77MP0002638_abnormal_pupillary_reflex1.08301571
78MP0000462_abnormal_digestive_system1.07901460
79MP0009250_abnormal_appendicular_skeleto1.07554672
80MP0009384_cardiac_valve_regurgitation1.05834038
81MP0003868_abnormal_feces_composition1.05765753
82MP0002108_abnormal_muscle_morphology1.04828991
83MP0001849_ear_inflammation1.04324421
84MP0003787_abnormal_imprinting1.03624698
85MP0005503_abnormal_tendon_morphology1.03150967
86MP0000490_abnormal_crypts_of1.02625178
87MP0002166_altered_tumor_susceptibility1.01230273
88MP0000534_abnormal_ureter_morphology1.01089580
89MP0001177_atelectasis1.00875312
90MP0010030_abnormal_orbit_morphology0.99317820
91MP0001879_abnormal_lymphatic_vessel0.98556899
92MP0003279_aneurysm0.98505133
93MP0008932_abnormal_embryonic_tissue0.95555408
94MP0002160_abnormal_reproductive_system0.95309469
95MP0001243_abnormal_dermal_layer0.94941163
96MP0000778_abnormal_nervous_system0.94612883
97MP0002006_tumorigenesis0.93413623
98MP0000749_muscle_degeneration0.92055842
99MP0003943_abnormal_hepatobiliary_system0.91947855
100MP0002019_abnormal_tumor_incidence0.91004061
101MP0000647_abnormal_sebaceous_gland0.90672838
102MP0002697_abnormal_eye_size0.90459375
103MP0009697_abnormal_copulation0.90294235
104MP0005365_abnormal_bile_salt0.90273423
105MP0001984_abnormal_olfaction0.89443269
106MP0001293_anophthalmia0.87136620
107MP0001286_abnormal_eye_development0.86887142
108MP0002751_abnormal_autonomic_nervous0.86611926
109MP0003942_abnormal_urinary_system0.86597137
110MP0000432_abnormal_head_morphology0.85810716
111MP0005253_abnormal_eye_physiology0.85335142
112MP0004036_abnormal_muscle_relaxation0.85130769
113MP0003115_abnormal_respiratory_system0.85093809
114MP0005621_abnormal_cell_physiology0.84372080
115MP0002177_abnormal_outer_ear0.82882579
116MP0004270_analgesia0.82235013
117MP0002925_abnormal_cardiovascular_devel0.82117583
118MP0002896_abnormal_bone_mineralization0.81816297
119MP0002837_dystrophic_cardiac_calcinosis0.80913456
120MP0008775_abnormal_heart_ventricle0.80489627
121MP0004272_abnormal_basement_membrane0.79893094
122MP0003935_abnormal_craniofacial_develop0.79474411
123MP0003755_abnormal_palate_morphology0.79273871
124MP0002090_abnormal_vision0.79155841
125MP0000428_abnormal_craniofacial_morphol0.78664736
126MP0005360_urolithiasis0.78584901
127MP0002168_other_aberrant_phenotype0.78315974
128MP0003567_abnormal_fetal_cardiomyocyte0.77808978
129MP0005623_abnormal_meninges_morphology0.77307392
130MP0003786_premature_aging0.77029692
131MP0002111_abnormal_tail_morphology0.76935453
132MP0000627_abnormal_mammary_gland0.76400652
133MP0005248_abnormal_Harderian_gland0.75590865
134MP0008877_abnormal_DNA_methylation0.73597644
135MP0002114_abnormal_axial_skeleton0.73342892
136MP0000538_abnormal_urinary_bladder0.73310766
137MP0005197_abnormal_uvea_morphology0.71573207
138MP0003119_abnormal_digestive_system0.71530735
139MP0005384_cellular_phenotype0.71125546
140MP0000427_abnormal_hair_cycle0.71079404
141MP0010386_abnormal_urinary_bladder0.70779578
142MP0002109_abnormal_limb_morphology0.70698747
143MP0005551_abnormal_eye_electrophysiolog0.70558697
144MP0001299_abnormal_eye_distance/0.70156417
145MP0000371_diluted_coat_color0.70041415
146MP0005508_abnormal_skeleton_morphology0.68915907
147MP0000537_abnormal_urethra_morphology0.68810209
148MP0005666_abnormal_adipose_tissue0.68749694
149MP0002115_abnormal_skeleton_extremities0.68317179
150MP0003941_abnormal_skin_development0.66224597
151MP0000598_abnormal_liver_morphology0.66074615
152MP0003453_abnormal_keratinocyte_physiol0.65923761
153MP0002928_abnormal_bile_duct0.65450234
154MP0003763_abnormal_thymus_physiology0.64087305
155MP0000609_abnormal_liver_physiology0.63953412
156MP0002113_abnormal_skeleton_development0.62818897
157MP0001119_abnormal_female_reproductive0.62202967

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)3.27659401
2Absent frontal sinuses (HP:0002688)3.12461560
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.95801555
4Short 4th metacarpal (HP:0010044)2.95801555
5Asymmetry of the thorax (HP:0001555)2.68889728
6Volvulus (HP:0002580)2.67507942
7Protrusio acetabuli (HP:0003179)2.58147525
8Hypoplastic ischia (HP:0003175)2.51522663
9Thyroid carcinoma (HP:0002890)2.49854768
10Syringomyelia (HP:0003396)2.49607153
11Spinal cord lesions (HP:0100561)2.49607153
12Ependymoma (HP:0002888)2.48659909
13Neoplasm of the adrenal cortex (HP:0100641)2.46190914
14Hypoglycemic seizures (HP:0002173)2.45741340
15Ankle contracture (HP:0006466)2.44403152
16Metaphyseal cupping (HP:0003021)2.42295048
17Abnormality of the ischium (HP:0003174)2.39730772
18Premature rupture of membranes (HP:0001788)2.39510244
19Biliary tract neoplasm (HP:0100574)2.39102792
20Hyperinsulinemic hypoglycemia (HP:0000825)2.37154002
21Astrocytoma (HP:0009592)2.34618593
22Abnormality of the astrocytes (HP:0100707)2.34618593
23Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.34392612
24Subacute progressive viral hepatitis (HP:0006572)2.34153644
25Papillary thyroid carcinoma (HP:0002895)2.32838711
26Abnormal foot bone ossification (HP:0010675)2.32369103
27Selective tooth agenesis (HP:0001592)2.27982368
28Abnormality of the calcaneus (HP:0008364)2.27711427
29Deviation of the thumb (HP:0009603)2.18894167
30Ulnar bowing (HP:0003031)2.14784079
31Medulloblastoma (HP:0002885)2.14013972
32Mesomelia (HP:0003027)2.13798692
33Abnormality of the fingertips (HP:0001211)2.13651159
34Intestinal atresia (HP:0011100)2.11930582
35Overgrowth (HP:0001548)2.11398499
36Agnosia (HP:0010524)2.09126039
37Abnormality of the 4th metacarpal (HP:0010012)2.07312573
38Cutaneous melanoma (HP:0012056)2.04582305
39Hypoglycemic coma (HP:0001325)2.04261033
40Sandal gap (HP:0001852)2.03749854
41High pitched voice (HP:0001620)2.03216022
42Chromsome breakage (HP:0040012)2.01214227
43Neoplasm of the oral cavity (HP:0100649)2.01106910
44Epiphyseal dysplasia (HP:0002656)2.00726028
45Calf muscle hypertrophy (HP:0008981)2.00324564
46Abnormal biliary tract morphology (HP:0012440)1.99378479
47Shallow orbits (HP:0000586)1.98717981
48Rhabdomyosarcoma (HP:0002859)1.96996772
49Vertebral clefting (HP:0008428)1.96527710
50Hamartoma of the eye (HP:0010568)1.95867104
51Lip pit (HP:0100267)1.95733439
52Abnormal pancreas size (HP:0012094)1.95058802
53Deep philtrum (HP:0002002)1.92974125
54Missing ribs (HP:0000921)1.91387759
55Hepatoblastoma (HP:0002884)1.91384599
56Fair hair (HP:0002286)1.90436828
57Long clavicles (HP:0000890)1.90111983
58Mitral valve prolapse (HP:0001634)1.89852480
59Broad thumb (HP:0011304)1.89139394
60Spastic diplegia (HP:0001264)1.89005725
61Bifid tongue (HP:0010297)1.88399354
62Radial bowing (HP:0002986)1.88182795
63Abnormality of endocrine pancreas physiology (HP:0012093)1.87508666
64Abnormality of the pancreatic islet cells (HP:0006476)1.87508666
65Cortical dysplasia (HP:0002539)1.86154685
66Abnormality of the peritoneum (HP:0002585)1.85648202
67Hypochromic microcytic anemia (HP:0004840)1.84308915
68Glioma (HP:0009733)1.84204938
69Pancreatic islet-cell hyperplasia (HP:0004510)1.83397877
70Macroorchidism (HP:0000053)1.83340585
71Stillbirth (HP:0003826)1.82603493
7211 pairs of ribs (HP:0000878)1.82424893
73Rhizomelia (HP:0008905)1.82077447
74Wormian bones (HP:0002645)1.81807826
75Chronic hepatic failure (HP:0100626)1.81323962
76Muscle hypertrophy of the lower extremities (HP:0008968)1.81236613
77Long eyelashes (HP:0000527)1.81080569
78Limited elbow extension (HP:0001377)1.80985498
79Heterotopia (HP:0002282)1.80575852
80Gastrointestinal carcinoma (HP:0002672)1.80318607
81Malignant gastrointestinal tract tumors (HP:0006749)1.80318607
82Abnormality of dentin (HP:0010299)1.79991980
83Cerebral aneurysm (HP:0004944)1.79781071
84Flared metaphyses (HP:0003015)1.79603517
85Broad palm (HP:0001169)1.79128735
86Osteolytic defects of the phalanges of the hand (HP:0009771)1.78433698
87Osteolytic defects of the hand bones (HP:0009699)1.78433698
88Increased density of long bones (HP:0006392)1.78012487
89Hyperglycemia (HP:0003074)1.77923049
90Narrow palate (HP:0000189)1.77883526
91Proximal placement of thumb (HP:0009623)1.77711191
92Short 5th finger (HP:0009237)1.77029632
93Peritonitis (HP:0002586)1.76690434
94Soft skin (HP:0000977)1.76203117
95Delayed gross motor development (HP:0002194)1.74792150
96Spondylolisthesis (HP:0003302)1.74508927
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74324000
98Delayed puberty (HP:0000823)1.74232812
99Small epiphyses (HP:0010585)1.73859397
100Atrophic scars (HP:0001075)1.72390311
101Cupped ribs (HP:0000887)1.71986146
102Hypoplastic labia majora (HP:0000059)1.71400946
103Vertebral hypoplasia (HP:0008417)1.71127709
104Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.71127709
105Abnormality of the frontal sinuses (HP:0002687)1.70670304
106Acute myeloid leukemia (HP:0004808)1.69914199
107Generalized hypopigmentation of hair (HP:0011358)1.69805075
108Tubulointerstitial nephritis (HP:0001970)1.69801821
109Truncal obesity (HP:0001956)1.69713806
110Overlapping toe (HP:0001845)1.68820675
111Arterial tortuosity (HP:0005116)1.68784966
112Urethral obstruction (HP:0000796)1.68441784
113Genital tract atresia (HP:0001827)1.67552791
114Broad long bones (HP:0005622)1.67413884
115Vascular tortuosity (HP:0004948)1.66687974
116Aortic aneurysm (HP:0004942)1.66462026
117Aortic dissection (HP:0002647)1.66443564
118Increased connective tissue (HP:0009025)1.66268127
119Short chin (HP:0000331)1.66238172
120Abnormality of the labia majora (HP:0012881)1.66038540
121Abnormality of chromosome stability (HP:0003220)1.65613676
122Abnormality of the labia minora (HP:0012880)1.65374902
123Gaze-evoked nystagmus (HP:0000640)1.65041440
124Fibular hypoplasia (HP:0003038)1.65023990
125Limited hip movement (HP:0008800)1.64735553
126Broad phalanx (HP:0006009)1.64622997
127Amaurosis fugax (HP:0100576)1.64430501
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.63229362
129Broad phalanges of the hand (HP:0009768)1.63058459
130Colon cancer (HP:0003003)1.61868550
131Fibrous tissue neoplasm (HP:0012316)1.61390865
132Flat acetabular roof (HP:0003180)1.60336168
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.60086487
134Short humerus (HP:0005792)1.60022430
135Dilatation of the ascending aorta (HP:0005111)1.59974005
136Vaginal atresia (HP:0000148)1.59555686
137Neoplasm of striated muscle (HP:0009728)1.59100033
138Congenital primary aphakia (HP:0007707)1.58696530
139Proximal amyotrophy (HP:0007126)1.57106277
140Drooling (HP:0002307)1.54815866
141Nemaline bodies (HP:0003798)1.53334797
142Follicular hyperkeratosis (HP:0007502)1.53201797
143Fibroma (HP:0010614)1.52011883
144Medial flaring of the eyebrow (HP:0010747)1.51714055
145Symptomatic seizures (HP:0011145)1.51682057
146Abnormality of the metopic suture (HP:0005556)1.50587041
147Ketoacidosis (HP:0001993)1.50315995
148Nephrogenic diabetes insipidus (HP:0009806)1.49838022
149Gait imbalance (HP:0002141)1.49330121
150Metaphyseal dysplasia (HP:0100255)1.48969937
151Neoplasm of the thyroid gland (HP:0100031)1.48870340
152Abnormality of the calf musculature (HP:0001430)1.48533940
153Neoplasm of the small intestine (HP:0100833)1.48241772
154Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.47694606
155Bowel diverticulosis (HP:0005222)1.47577441
156Gonadotropin excess (HP:0000837)1.47234505
157Decreased lacrimation (HP:0000633)1.47203012
158Termporal pattern (HP:0011008)1.47035691
159Insidious onset (HP:0003587)1.47035691
160Lymphangioma (HP:0100764)1.46683713
161Hypopigmentation of the fundus (HP:0007894)1.45336311
162* Pulmonic stenosis (HP:0001642)1.45146173
163Vertebral arch anomaly (HP:0008438)1.45116153
164Aqueductal stenosis (HP:0002410)1.44966410
165Neoplasm of the adrenal gland (HP:0100631)1.44117496
166Benign neoplasm of the central nervous system (HP:0100835)1.43632051
167Menstrual irregularities (HP:0000858)1.43228893
168Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.42259952
169Hip dysplasia (HP:0001385)1.41977596
170Prominent metopic ridge (HP:0005487)1.41084764
171Cutaneous finger syndactyly (HP:0010554)1.40576813
172Abnormality of the epiphyses of the hand (HP:0005924)1.40175503
173Aplasia/Hypoplasia of the fibula (HP:0006492)1.39546764
174Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.39516373
175Abnormality of the antihelix (HP:0009738)1.39485838

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.05011795
2CDK123.91627717
3PNCK3.65098783
4CDC73.42562345
5EEF2K3.13020572
6PKN22.48411302
7FGFR22.36968610
8CASK2.28578593
9PASK2.23803433
10TTN2.11932361
11TTK2.01421281
12STK101.98032086
13STK31.96039787
14TNIK1.94108982
15RPS6KB21.87965693
16PBK1.74608322
17FRK1.68317382
18CAMK1D1.67010642
19FLT31.61279728
20BMPR1B1.58746693
21NEK21.57778979
22FER1.52576017
23AKT31.50510031
24BCR1.50150405
25MKNK21.47871625
26SCYL21.47610916
27MAP3K41.44004728
28WNK31.42816738
29MAP3K81.42460562
30STK391.42080057
31STK38L1.41749247
32TAOK31.41588149
33TRIM281.40861268
34ATR1.40752950
35EPHA21.31208039
36AURKB1.29931008
37DDR21.28855027
38OBSCN1.28322686
39TGFBR11.26044237
40PAK31.21748920
41TRIB31.21270810
42LRRK21.20451392
43JAK31.20253831
44PDGFRA1.18862180
45MARK11.18812538
46MTOR1.17172963
47CDK61.15980103
48ERBB41.14914800
49MAPKAPK31.14769133
50LATS21.13051311
51MELK1.12990568
52ATM1.12862008
53CHEK11.12570925
54PLK41.12445890
55WEE11.11202468
56SIK11.10711780
57TRPM71.09889984
58ZAK1.09805782
59RIPK11.09166058
60TIE11.09159214
61ACVR1B1.08299948
62TYK21.07585960
63BRD41.07470728
64BRSK21.05913379
65SRPK11.05599251
66MET1.04100965
67MAP3K31.02898663
68PDK21.02808586
69PLK31.02162248
70CHEK21.02123045
71PHKG11.02009480
72PHKG21.02009480
73CCNB11.01370253
74TSSK60.98438560
75NLK0.97559057
76MST40.96639063
77CDK40.95148049
78FGFR10.94239936
79PLK10.93795965
80JAK10.92567853
81PAK20.90969450
82FGFR30.90466613
83PIM10.86879322
84CSNK1G10.86267400
85PTK60.86184160
86CAMKK20.85315804
87CDK70.83891815
88MAP2K30.83437338
89PLK20.82217134
90RPS6KA40.81316077
91NTRK30.79488197
92STK240.78325438
93MAP3K100.77717714
94PDGFRB0.77588719
95CAMK1G0.77095189
96NEK10.76364660
97BMX0.73576006
98CDK20.72371878
99EIF2AK30.72205893
100NUAK10.71005179
101EIF2AK10.70735229
102STK40.70533459
103RPS6KB10.69872433
104NEK90.68308487
105ALK0.66606048
106ITK0.66350843
107CSNK1D0.66200988
108MYLK0.64612048
109YES10.64349405
110CHUK0.63624890
111MAP3K20.62732948
112CDK10.61832909
113CSF1R0.60400732
114SGK20.58903575
115PRKDC0.58461302
116FGFR40.57700156
117PRKCE0.57340706
118ROCK10.56253159
119CDK30.55825590
120MKNK10.54700598
121CDK90.52699363
122PRKAA20.52497045
123INSRR0.51911998
124PIK3CA0.51400958
125PRKAA10.50009487
126EPHA40.49871164
127VRK10.48833141
128WNK10.46581539
129MAPK140.46411018
130PTK20.45531219
131MAPK110.45510148
132MAP3K120.43512940
133PIK3CG0.43385562
134MAPK10.42582520
135BUB10.40791388
136CSNK1G30.38827707
137CSNK1A1L0.38335629
138OXSR10.38249931
139MST1R0.37954927
140AKT10.37370686
141PAK40.36746940
142ERBB30.36728567
143CSK0.36349896
144ROCK20.36138777
145CSNK1E0.36062577
146MAP3K140.36019885
147CSNK1G20.35643146
148INSR0.34808014
149RET0.32337002

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.68741351
2Protein export_Homo sapiens_hsa030602.79048812
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.61662627
4Mismatch repair_Homo sapiens_hsa034302.46662793
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44396501
6Cell cycle_Homo sapiens_hsa041102.42947254
7RNA transport_Homo sapiens_hsa030132.32883148
8Non-homologous end-joining_Homo sapiens_hsa034502.26712798
9Propanoate metabolism_Homo sapiens_hsa006402.25381974
10DNA replication_Homo sapiens_hsa030302.18218103
11Selenocompound metabolism_Homo sapiens_hsa004502.16828951
12Systemic lupus erythematosus_Homo sapiens_hsa053222.14125695
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92854149
14Circadian rhythm_Homo sapiens_hsa047101.88078160
15Adherens junction_Homo sapiens_hsa045201.68334762
16Lysine degradation_Homo sapiens_hsa003101.67140822
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65625916
18MicroRNAs in cancer_Homo sapiens_hsa052061.60969516
19Nucleotide excision repair_Homo sapiens_hsa034201.59748772
20Viral carcinogenesis_Homo sapiens_hsa052031.59196088
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56604064
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56020858
23p53 signaling pathway_Homo sapiens_hsa041151.52392090
24Steroid biosynthesis_Homo sapiens_hsa001001.52383578
25* RNA degradation_Homo sapiens_hsa030181.49908918
26Fanconi anemia pathway_Homo sapiens_hsa034601.48248283
27Small cell lung cancer_Homo sapiens_hsa052221.43531777
28Butanoate metabolism_Homo sapiens_hsa006501.42472334
29Homologous recombination_Homo sapiens_hsa034401.39479248
30ECM-receptor interaction_Homo sapiens_hsa045121.37795068
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35716350
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27619105
33mRNA surveillance pathway_Homo sapiens_hsa030151.26011451
34mTOR signaling pathway_Homo sapiens_hsa041501.25498115
35Spliceosome_Homo sapiens_hsa030401.23388205
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.22288317
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21974983
38Fatty acid metabolism_Homo sapiens_hsa012121.21186258
39Base excision repair_Homo sapiens_hsa034101.21167256
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21105807
41Antigen processing and presentation_Homo sapiens_hsa046121.18962398
42Hedgehog signaling pathway_Homo sapiens_hsa043401.15247295
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11259637
44Proteoglycans in cancer_Homo sapiens_hsa052051.10768214
45Focal adhesion_Homo sapiens_hsa045101.10158999
46TGF-beta signaling pathway_Homo sapiens_hsa043501.10085914
47Fatty acid elongation_Homo sapiens_hsa000621.09155307
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08473860
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05288951
50Pyruvate metabolism_Homo sapiens_hsa006200.98345287
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98191053
52HTLV-I infection_Homo sapiens_hsa051660.97178935
53Nitrogen metabolism_Homo sapiens_hsa009100.97006470
54Tight junction_Homo sapiens_hsa045300.96887569
55Dilated cardiomyopathy_Homo sapiens_hsa054140.96582687
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.94487083
57Herpes simplex infection_Homo sapiens_hsa051680.93056668
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92560696
59Chronic myeloid leukemia_Homo sapiens_hsa052200.92254005
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91817703
61Insulin secretion_Homo sapiens_hsa049110.91709004
62Thyroid cancer_Homo sapiens_hsa052160.90802832
63Pancreatic cancer_Homo sapiens_hsa052120.90272830
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89882386
65Epstein-Barr virus infection_Homo sapiens_hsa051690.85043968
66Fatty acid biosynthesis_Homo sapiens_hsa000610.84441130
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83063721
68Renin secretion_Homo sapiens_hsa049240.82263455
69Sphingolipid metabolism_Homo sapiens_hsa006000.82026095
70Biosynthesis of amino acids_Homo sapiens_hsa012300.81555964
71Prostate cancer_Homo sapiens_hsa052150.81237598
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81008303
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.80952359
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78750196
75Wnt signaling pathway_Homo sapiens_hsa043100.78639407
76Basal transcription factors_Homo sapiens_hsa030220.78595660
77Thyroid hormone synthesis_Homo sapiens_hsa049180.78461491
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76640455
79Fatty acid degradation_Homo sapiens_hsa000710.75956983
80Inositol phosphate metabolism_Homo sapiens_hsa005620.73483124
81Colorectal cancer_Homo sapiens_hsa052100.72513459
82Hippo signaling pathway_Homo sapiens_hsa043900.71178775
83Renin-angiotensin system_Homo sapiens_hsa046140.70652531
84Complement and coagulation cascades_Homo sapiens_hsa046100.70344338
85Caffeine metabolism_Homo sapiens_hsa002320.69993518
86Insulin resistance_Homo sapiens_hsa049310.69613281
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.68266995
88Toxoplasmosis_Homo sapiens_hsa051450.66782304
89Arginine biosynthesis_Homo sapiens_hsa002200.65086622
90NF-kappa B signaling pathway_Homo sapiens_hsa040640.64745580
91Protein digestion and absorption_Homo sapiens_hsa049740.63777421
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.63715410
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63549635
94Glioma_Homo sapiens_hsa052140.62801003
95Melanogenesis_Homo sapiens_hsa049160.62275218
96Dopaminergic synapse_Homo sapiens_hsa047280.62150211
97Bladder cancer_Homo sapiens_hsa052190.61224734
98Endometrial cancer_Homo sapiens_hsa052130.61046883
99Regulation of autophagy_Homo sapiens_hsa041400.60719764
100Viral myocarditis_Homo sapiens_hsa054160.59800117
101Non-small cell lung cancer_Homo sapiens_hsa052230.59451766
102Apoptosis_Homo sapiens_hsa042100.58964609
103Long-term depression_Homo sapiens_hsa047300.58642401
104Hepatitis B_Homo sapiens_hsa051610.57318911
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57247331
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57200542
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56398987
108Amoebiasis_Homo sapiens_hsa051460.56208774
109Measles_Homo sapiens_hsa051620.55584621
110Axon guidance_Homo sapiens_hsa043600.55539897
111Gap junction_Homo sapiens_hsa045400.55526561
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55368961
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54868947
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54442439
115AMPK signaling pathway_Homo sapiens_hsa041520.53262188
116Tryptophan metabolism_Homo sapiens_hsa003800.51814329
117Dorso-ventral axis formation_Homo sapiens_hsa043200.51319064
118Type II diabetes mellitus_Homo sapiens_hsa049300.51239613
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51182185
120Sulfur metabolism_Homo sapiens_hsa009200.50843749
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.50364528
122Legionellosis_Homo sapiens_hsa051340.49320166
123FoxO signaling pathway_Homo sapiens_hsa040680.48866645
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.46968459
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46960220
1262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46698609
127Alcoholism_Homo sapiens_hsa050340.46406497
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44753091
129Starch and sucrose metabolism_Homo sapiens_hsa005000.44749097
130Taste transduction_Homo sapiens_hsa047420.44722122
131Melanoma_Homo sapiens_hsa052180.42769647
132Amphetamine addiction_Homo sapiens_hsa050310.42596657
133Basal cell carcinoma_Homo sapiens_hsa052170.42550860
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42463362
135Glucagon signaling pathway_Homo sapiens_hsa049220.42118451
136Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41998678
137Pathways in cancer_Homo sapiens_hsa052000.41776087
138Oocyte meiosis_Homo sapiens_hsa041140.41588926
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41004297
140Glutamatergic synapse_Homo sapiens_hsa047240.40147765
141Influenza A_Homo sapiens_hsa051640.37914046
142N-Glycan biosynthesis_Homo sapiens_hsa005100.36109456
143Platelet activation_Homo sapiens_hsa046110.35749261
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33534822
145Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33225638
146Prolactin signaling pathway_Homo sapiens_hsa049170.33083553
147Carbon metabolism_Homo sapiens_hsa012000.31563058

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