TTC39A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.06191775
2Golgi transport vesicle coating (GO:0048200)9.06191775
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.77711683
4protein retention in ER lumen (GO:0006621)6.10273689
5signal peptide processing (GO:0006465)5.89782559
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.71630806
7endocrine pancreas development (GO:0031018)5.56578499
8COPII vesicle coating (GO:0048208)5.47071122
9exocrine pancreas development (GO:0031017)5.03252540
10peptide hormone processing (GO:0016486)4.90963261
11nitric oxide biosynthetic process (GO:0006809)4.78631349
12ER overload response (GO:0006983)4.73813463
13melanin biosynthetic process (GO:0042438)4.73764228
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.71393398
15glandular epithelial cell differentiation (GO:0002067)4.65495427
16desmosome organization (GO:0002934)4.57696152
17sperm motility (GO:0030317)4.49673453
18positive regulation of nuclease activity (GO:0032075)4.42507698
19intra-Golgi vesicle-mediated transport (GO:0006891)4.42228949
20ketone body metabolic process (GO:1902224)4.40827228
21UDP-N-acetylglucosamine metabolic process (GO:0006047)4.38148665
22nucleotide-sugar biosynthetic process (GO:0009226)4.36806011
23intestinal epithelial cell development (GO:0060576)4.36012922
24fusion of sperm to egg plasma membrane (GO:0007342)4.32122820
25cell wall macromolecule catabolic process (GO:0016998)4.31894927
26cell wall macromolecule metabolic process (GO:0044036)4.31894927
27GDP-mannose metabolic process (GO:0019673)4.31328720
28protein maturation by protein folding (GO:0022417)4.31101661
29melanin metabolic process (GO:0006582)4.19410882
30sequestering of metal ion (GO:0051238)4.14931769
31ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.11541593
32cellular response to unfolded protein (GO:0034620)4.08671184
33acrosome assembly (GO:0001675)4.06438346
34protein N-linked glycosylation via asparagine (GO:0018279)4.05518705
35endoplasmic reticulum unfolded protein response (GO:0030968)4.04228120
36regulation of nuclease activity (GO:0032069)4.03326349
37peptidyl-asparagine modification (GO:0018196)4.02815570
38vesicle coating (GO:0006901)4.01039420
39acrosome reaction (GO:0007340)4.00046797
40negative regulation of glycogen biosynthetic process (GO:0045719)3.99670105
41keratinocyte development (GO:0003334)3.96822108
42regulation of water loss via skin (GO:0033561)3.90829757
43multicellular organism reproduction (GO:0032504)3.90426810
44cellular response to topologically incorrect protein (GO:0035967)3.88582097
45intestinal cholesterol absorption (GO:0030299)3.86387018
46secondary metabolite biosynthetic process (GO:0044550)3.85016021
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.81026498
48ER-nucleus signaling pathway (GO:0006984)3.78305317
49cellular ketone body metabolic process (GO:0046950)3.75274998
50axonemal dynein complex assembly (GO:0070286)3.72788748
51bundle of His cell to Purkinje myocyte communication (GO:0086069)3.67398606
52protein N-linked glycosylation (GO:0006487)3.67014928
53purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.65611617
543-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.65611617
55epithelial cilium movement (GO:0003351)3.63538047
56insulin secretion (GO:0030073)3.62889238
57response to endoplasmic reticulum stress (GO:0034976)3.62374138
58amyloid precursor protein catabolic process (GO:0042987)3.59487540
59spermatid development (GO:0007286)3.59197790
60regulation of type B pancreatic cell apoptotic process (GO:2000674)3.53151475
61nucleotide-sugar metabolic process (GO:0009225)3.52056784
62regulation of hexokinase activity (GO:1903299)3.50636630
63regulation of glucokinase activity (GO:0033131)3.50636630
64pharyngeal system development (GO:0060037)3.49803148
65reproduction (GO:0000003)3.47874171
66sperm-egg recognition (GO:0035036)3.47406929
67epithelial cell maturation (GO:0002070)3.47045349
68columnar/cuboidal epithelial cell development (GO:0002066)3.43917049
69calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.42610508
70response to unfolded protein (GO:0006986)3.38021265
71cilium or flagellum-dependent cell motility (GO:0001539)3.37417186
72regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.37104835
73cilium movement (GO:0003341)3.36520601
74macroautophagy (GO:0016236)3.36189556
75left/right pattern formation (GO:0060972)3.34374742
76intraciliary transport (GO:0042073)3.32824370
77intestinal absorption (GO:0050892)3.32336015
78negative regulation of glycogen metabolic process (GO:0070874)3.31075117
79interleukin-1-mediated signaling pathway (GO:0070498)3.30461974
80short-chain fatty acid metabolic process (GO:0046459)3.30385590
81multicellular organismal water homeostasis (GO:0050891)3.30317192
82norepinephrine metabolic process (GO:0042415)3.28175571
83positive regulation of insulin secretion (GO:0032024)3.27838655
84type B pancreatic cell development (GO:0003323)3.25769537
85digestion (GO:0007586)3.23649255
86plasma membrane fusion (GO:0045026)3.22536767
87response to topologically incorrect protein (GO:0035966)3.22534477
88nucleoside diphosphate catabolic process (GO:0009134)3.22086040
89xenobiotic catabolic process (GO:0042178)3.21873361
90cellular zinc ion homeostasis (GO:0006882)3.17563278
91protein targeting to Golgi (GO:0000042)3.17499181
92ER to Golgi vesicle-mediated transport (GO:0006888)3.16146428
93cell-cell recognition (GO:0009988)3.15594019
94sphingomyelin metabolic process (GO:0006684)3.14511255
95protein localization to Golgi apparatus (GO:0034067)3.13893023
96negative regulation of glycoprotein biosynthetic process (GO:0010561)3.13782652
97L-alpha-amino acid transmembrane transport (GO:1902475)3.13026530
98establishment of skin barrier (GO:0061436)3.12368401
99detection of calcium ion (GO:0005513)3.11451458
100L-phenylalanine metabolic process (GO:0006558)3.09025481
101erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.09025481
102zinc ion transmembrane transport (GO:0071577)3.08881102
103regulation of acrosome reaction (GO:0060046)3.07318664
104sperm capacitation (GO:0048240)3.06814151
105pyrimidine ribonucleoside catabolic process (GO:0046133)3.04974942
106regulation of insulin secretion (GO:0050796)3.01362563
107peptide catabolic process (GO:0043171)3.00318440
108toxin transport (GO:1901998)2.99227507
109cell redox homeostasis (GO:0045454)2.99187495
110water homeostasis (GO:0030104)2.98406561
111negative regulation of keratinocyte proliferation (GO:0010839)2.98126900
112positive regulation of keratinocyte differentiation (GO:0045618)2.97930663
113biotin metabolic process (GO:0006768)2.96186887
114regulation of cilium movement (GO:0003352)2.95977328
115ceramide catabolic process (GO:0046514)2.95291155
116dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.94689405
117calcium ion-dependent exocytosis (GO:0017156)2.93731585
118auditory receptor cell differentiation (GO:0042491)2.93425236
119establishment of protein localization to Golgi (GO:0072600)2.93226949
120glutathione derivative biosynthetic process (GO:1901687)2.92187884
121glutathione derivative metabolic process (GO:1901685)2.92187884
122glandular epithelial cell development (GO:0002068)2.90489246
123carnitine transport (GO:0015879)2.88480376
124amino-acid betaine transport (GO:0015838)2.88480376
125oocyte development (GO:0048599)2.87302546
126cellular response to vitamin D (GO:0071305)2.87206010
127binding of sperm to zona pellucida (GO:0007339)2.87079445
128regulation of autophagic vacuole assembly (GO:2000785)2.86585327
129phenylpropanoid metabolic process (GO:0009698)2.85110288
130organic cation transport (GO:0015695)2.83233907
131regulation of cardioblast proliferation (GO:0003264)2.83024690
132regulation of secondary heart field cardioblast proliferation (GO:0003266)2.83024690
133regulation of cell proliferation involved in kidney development (GO:1901722)2.82495000
134lactate metabolic process (GO:0006089)2.81574731
135fucose metabolic process (GO:0006004)2.81430286
136positive regulation of glycolytic process (GO:0045821)2.80795705
137Golgi organization (GO:0007030)2.80667137
138glycolipid catabolic process (GO:0019377)2.80205904
139retrograde transport, vesicle recycling within Golgi (GO:0000301)2.79990845
140myelin maintenance (GO:0043217)2.75818412
141positive regulation of macroautophagy (GO:0016239)2.75224121
142zinc ion homeostasis (GO:0055069)2.72645645
143negative regulation of neurological system process (GO:0031645)2.72467705
144prostate gland growth (GO:0060736)2.71168972
145positive regulation of epidermal cell differentiation (GO:0045606)2.68685249
146diol metabolic process (GO:0034311)2.67332447
147flavonoid metabolic process (GO:0009812)2.66976642
148pigment cell differentiation (GO:0050931)2.66760486
149amyloid precursor protein metabolic process (GO:0042982)2.65646824
150ear development (GO:0043583)2.64789643
151phosphatidylethanolamine biosynthetic process (GO:0006646)2.63758333
152inositol phosphate catabolic process (GO:0071545)2.63616284
153cardiac right ventricle morphogenesis (GO:0003215)2.61629706
154glutathione biosynthetic process (GO:0006750)2.61309455
155zinc ion transport (GO:0006829)2.56576130
156columnar/cuboidal epithelial cell differentiation (GO:0002065)2.55805117
157phenol-containing compound biosynthetic process (GO:0046189)2.53629582
158inositol phosphate dephosphorylation (GO:0046855)2.51445269
159phosphorylated carbohydrate dephosphorylation (GO:0046838)2.51445269
160vitamin transmembrane transport (GO:0035461)2.49341587
161branched-chain amino acid catabolic process (GO:0009083)2.48823225
162polyol catabolic process (GO:0046174)2.47340511
163regulation of vacuole organization (GO:0044088)2.46146091
164motile cilium assembly (GO:0044458)2.45585084
165phosphatidylethanolamine metabolic process (GO:0046337)2.43833610
166trivalent inorganic anion homeostasis (GO:0072506)2.43394056
167phosphate ion homeostasis (GO:0055062)2.43394056
168melanocyte differentiation (GO:0030318)2.42636513
169early endosome to late endosome transport (GO:0045022)2.42272327
170tight junction assembly (GO:0070830)2.41852303
171cellular response to oxygen radical (GO:0071450)2.41479233
172removal of superoxide radicals (GO:0019430)2.41479233
173cellular response to superoxide (GO:0071451)2.41479233
174negative regulation of organelle assembly (GO:1902116)2.39637653
175epithelial cell fate commitment (GO:0072148)2.36650978
176regulation of keratinocyte differentiation (GO:0045616)2.35644357
177axoneme assembly (GO:0035082)2.35349501
178primary alcohol catabolic process (GO:0034310)2.35209344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human6.10830550
2ESR2_21235772_ChIP-Seq_MCF-7_Human4.25896341
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59192739
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39042825
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27772249
6ESR1_15608294_ChIP-ChIP_MCF-7_Human2.88974391
7RUNX1_27514584_Chip-Seq_MCF-7_Human2.50607864
8HIF1A_21447827_ChIP-Seq_MCF-7_Human2.36736414
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19464596
10CDX2_20551321_ChIP-Seq_CACO-2_Human2.18975908
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.05626955
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.02908515
13* RACK7_27058665_Chip-Seq_MCF-7_Human2.02773699
14ER_23166858_ChIP-Seq_MCF-7_Human1.94514125
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89685186
16FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.81946218
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.78063155
18ELF5_23300383_ChIP-Seq_T47D_Human1.77686798
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77144483
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.74383494
21ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72187533
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.71585684
23DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.69459209
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68368561
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67754565
26MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63610574
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.62403522
28GATA1_22025678_ChIP-Seq_K562_Human1.60405541
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58954482
30GATA4_25053715_ChIP-Seq_YYC3_Human1.57742452
31RXR_22158963_ChIP-Seq_LIVER_Mouse1.57329266
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.57029769
33FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54861976
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53229092
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.53106414
36KDM5A_27292631_Chip-Seq_BREAST_Human1.51546577
37TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48491562
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.47122370
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.46284475
40STAT3_18555785_Chip-Seq_ESCs_Mouse1.46121796
41* HOXB7_26014856_ChIP-Seq_BT474_Human1.46023744
42ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.46020801
43* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45954770
44P53_22387025_ChIP-Seq_ESCs_Mouse1.45780381
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45695960
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45087442
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44736174
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44595209
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.44444502
50KLF5_25053715_ChIP-Seq_YYC3_Human1.43717595
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.42936641
52ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40584755
53SOX2_18555785_Chip-Seq_ESCs_Mouse1.39924215
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.38240391
55NMYC_18555785_Chip-Seq_ESCs_Mouse1.37508174
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35979270
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34527489
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33793157
59VDR_22108803_ChIP-Seq_LS180_Human1.33581015
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33042962
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.31184401
62GBX2_23144817_ChIP-Seq_PC3_Human1.30749689
63PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30381919
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29511014
65SOX2_20726797_ChIP-Seq_SW620_Human1.29047864
66ZNF263_19887448_ChIP-Seq_K562_Human1.28501186
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28025029
68ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27687780
69FOXA1_25552417_ChIP-Seq_VCAP_Human1.27500153
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.27053112
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.26227242
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.25349645
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25282110
74* CDX2_22108803_ChIP-Seq_LS180_Human1.25146826
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.24213324
76ERG_20517297_ChIP-Seq_VCAP_Human1.23145874
77ERA_21632823_ChIP-Seq_H3396_Human1.22629086
78ZFX_18555785_Chip-Seq_ESCs_Mouse1.20660771
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20497000
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20027966
81P300_18555785_Chip-Seq_ESCs_Mouse1.18727101
82OCT4_18555785_Chip-Seq_ESCs_Mouse1.18155326
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17773082
84PU1_27457419_Chip-Seq_LIVER_Mouse1.16046349
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.15057476
86E2F1_18555785_Chip-Seq_ESCs_Mouse1.14563783
87BCAT_22108803_ChIP-Seq_LS180_Human1.14441393
88SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13859319
89TCF4_22108803_ChIP-Seq_LS180_Human1.12841205
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12151501
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11905672
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10650355
93* ARNT_22903824_ChIP-Seq_MCF-7_Human1.08658106
94ZNF274_21170338_ChIP-Seq_K562_Hela1.08594974
95TFEB_21752829_ChIP-Seq_HELA_Human1.07888813
96* KDM2B_26808549_Chip-Seq_REH_Human1.07625650
97TCF4_23295773_ChIP-Seq_U87_Human1.07223122
98* AHR_22903824_ChIP-Seq_MCF-7_Human1.06799210
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.06287905
100CHD1_26751641_Chip-Seq_LNCaP_Human1.05866361
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05676725
102STAT3_23295773_ChIP-Seq_U87_Human1.05634133
103GATA6_25053715_ChIP-Seq_YYC3_Human1.05590445
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04572544
105CTCF_18555785_Chip-Seq_ESCs_Mouse1.03951262
106STAT1_17558387_ChIP-Seq_HELA_Human1.03731605
107TP63_23658742_ChIP-Seq_EP156T_Human1.03723574
108SMAD4_21799915_ChIP-Seq_A2780_Human1.02640003
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.01831868
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01740098
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01641634
112CBP_20019798_ChIP-Seq_JUKART_Human1.01641634
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00365014
114GF1B_26923725_Chip-Seq_HPCs_Mouse0.99941698
115P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99525253
116* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99147671
117* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99147671
118AR_20517297_ChIP-Seq_VCAP_Human0.98643756
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97739417
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97300172
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97106722
122AR_25329375_ChIP-Seq_VCAP_Human0.96565714
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96471089
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96429831
125FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96257838
126HTT_18923047_ChIP-ChIP_STHdh_Human0.94343994
127* CJUN_26792858_Chip-Seq_BT549_Human0.94026159
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93520773
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93457759
130SMC4_20622854_ChIP-Seq_HELA_Human0.93342098
131KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92390310
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92115510
133RUNX1_26923725_Chip-Seq_HPCs_Mouse0.91712932
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.91241586
135CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90879996
136ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89681336
137P53_21459846_ChIP-Seq_SAOS-2_Human0.89579157
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89440651
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89029733
140FOXA2_19822575_ChIP-Seq_HepG2_Human0.88734203
141* GATA3_24758297_ChIP-Seq_MCF-7_Human0.87855315
142LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87768098
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.87378806
144* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86668322
145* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86549032
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86347177
147HNF4A_19822575_ChIP-Seq_HepG2_Human0.84586424
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84109511
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82215319
150* GATA3_21878914_ChIP-Seq_MCF-7_Human0.81636286
151RAC3_21632823_ChIP-Seq_H3396_Human0.81424843
152OCT4_20526341_ChIP-Seq_ESCs_Human0.80188666
153CREB1_26743006_Chip-Seq_LNCaP_Human0.79936264
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77311678
155ATF3_27146783_Chip-Seq_COLON_Human0.77256382
156* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76794140
157CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.76128605
158* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75289051
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73987577
160* RBPJ_21746931_ChIP-Seq_IB4_Human0.72944051
161* TP63_22573176_ChIP-Seq_HFKS_Human0.72145372
162* GATA6_21074721_ChIP-Seq_CACO-2_Human0.71470104
163* HNFA_21074721_ChIP-Seq_CACO-2_Human0.69991146
164PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.69399651
165* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68640027
166E2F1_20622854_ChIP-Seq_HELA_Human0.67973555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.58262655
2MP0010386_abnormal_urinary_bladder4.19089388
3MP0002693_abnormal_pancreas_physiology3.71037496
4MP0003183_abnormal_peptide_metabolism3.70726437
5MP0005410_abnormal_fertilization3.65259654
6MP0004264_abnormal_extraembryonic_tissu3.35236564
7MP0005220_abnormal_exocrine_pancreas3.29333544
8MP0000678_abnormal_parathyroid_gland3.20004654
9MP0001944_abnormal_pancreas_morphology3.13295387
10MP0004043_abnormal_pH_regulation3.06733409
11MP0005379_endocrine/exocrine_gland_phen3.02965775
12MP0009780_abnormal_chondrocyte_physiolo3.00657187
13MP0000013_abnormal_adipose_tissue2.99502381
14MP0005075_abnormal_melanosome_morpholog2.91841210
15MP0002909_abnormal_adrenal_gland2.88239475
16MP0003195_calcinosis2.52191083
17MP0002138_abnormal_hepatobiliary_system2.48583560
18MP0001666_abnormal_nutrient_absorption2.47602654
19MP0010234_abnormal_vibrissa_follicle2.42867386
20MP0004381_abnormal_hair_follicle2.29233169
21MP0003283_abnormal_digestive_organ2.26608556
22MP0003806_abnormal_nucleotide_metabolis2.16955077
23MP0002876_abnormal_thyroid_physiology2.16627169
24MP0000427_abnormal_hair_cycle2.12800047
25MP0001765_abnormal_ion_homeostasis2.12475626
26MP0002796_impaired_skin_barrier2.07221743
27MP0002837_dystrophic_cardiac_calcinosis2.07070825
28MP0005310_abnormal_salivary_gland2.07042530
29MP0005083_abnormal_biliary_tract2.06310668
30MP0003868_abnormal_feces_composition2.05908587
31MP0005248_abnormal_Harderian_gland2.03591083
32MP0000383_abnormal_hair_follicle2.03251668
33MP0000371_diluted_coat_color1.97949819
34MP0000015_abnormal_ear_pigmentation1.96899484
35MP0005365_abnormal_bile_salt1.93410555
36MP0005645_abnormal_hypothalamus_physiol1.77459217
37MP0005171_absent_coat_pigmentation1.77007571
38MP0000003_abnormal_adipose_tissue1.76183673
39MP0002078_abnormal_glucose_homeostasis1.75317799
40MP0002254_reproductive_system_inflammat1.73257345
41MP0000613_abnormal_salivary_gland1.72830628
42MP0002163_abnormal_gland_morphology1.71102653
43MP0003300_gastrointestinal_ulcer1.69416332
44MP0001986_abnormal_taste_sensitivity1.69117387
45MP0002928_abnormal_bile_duct1.66748140
46MP0003878_abnormal_ear_physiology1.60924654
47MP0005377_hearing/vestibular/ear_phenot1.60924654
48MP0006072_abnormal_retinal_apoptosis1.58219638
49MP0001664_abnormal_digestion1.56543776
50MP0003136_yellow_coat_color1.49920125
51MP0002896_abnormal_bone_mineralization1.48753410
52MP0008875_abnormal_xenobiotic_pharmacok1.48131810
53MP0008004_abnormal_stomach_pH1.47990052
54MP0005084_abnormal_gallbladder_morpholo1.47681871
55MP0002009_preneoplasia1.47076954
56MP0002277_abnormal_respiratory_mucosa1.44878001
57MP0003123_paternal_imprinting1.43020720
58MP0000538_abnormal_urinary_bladder1.41140134
59MP0002234_abnormal_pharynx_morphology1.39804296
60MP0004019_abnormal_vitamin_homeostasis1.39151662
61MP0005174_abnormal_tail_pigmentation1.36336390
62MP0003866_abnormal_defecation1.31964699
63MP0001346_abnormal_lacrimal_gland1.30936221
64MP0000462_abnormal_digestive_system1.30574448
65MP0005646_abnormal_pituitary_gland1.29683138
66MP0005636_abnormal_mineral_homeostasis1.29347021
67MP0003698_abnormal_male_reproductive1.28761534
68MP0002098_abnormal_vibrissa_morphology1.25388767
69MP0004782_abnormal_surfactant_physiolog1.24989707
70MP0000377_abnormal_hair_follicle1.23857511
71MP0009643_abnormal_urine_homeostasis1.23357502
72MP0003953_abnormal_hormone_level1.22808403
73MP0001881_abnormal_mammary_gland1.21226943
74MP0001929_abnormal_gametogenesis1.20226764
75MP0005332_abnormal_amino_acid1.17665197
76MP0001756_abnormal_urination1.17173494
77MP0005670_abnormal_white_adipose1.17030443
78MP0000627_abnormal_mammary_gland1.16068858
79MP0002938_white_spotting1.14942275
80MP0002090_abnormal_vision1.12743132
81MP0010329_abnormal_lipoprotein_level1.11339339
82MP0004233_abnormal_muscle_weight1.08045270
83MP0003959_abnormal_lean_body1.06438067
84MP0001270_distended_abdomen1.05181717
85MP0000681_abnormal_thyroid_gland1.04232434
86MP0003045_fibrosis1.03893211
87MP0001873_stomach_inflammation1.03336089
88MP0008961_abnormal_basal_metabolism1.03270875
89MP0001324_abnormal_eye_pigmentation1.02940072
90MP0001502_abnormal_circadian_rhythm1.02813954
91MP0000470_abnormal_stomach_morphology1.00661790
92MP0002075_abnormal_coat/hair_pigmentati0.99874394
93MP0001186_pigmentation_phenotype0.97669858
94MP0002160_abnormal_reproductive_system0.96755196
95MP0005501_abnormal_skin_physiology0.96676340
96MP0002095_abnormal_skin_pigmentation0.95852844
97MP0010352_gastrointestinal_tract_polyps0.95651253
98MP0008877_abnormal_DNA_methylation0.95344112
99MP0005408_hypopigmentation0.94542236
100MP0009840_abnormal_foam_cell0.92469008
101MP0002638_abnormal_pupillary_reflex0.91845264
102MP0003252_abnormal_bile_duct0.89986999
103MP0004147_increased_porphyrin_level0.88823955
104MP0003936_abnormal_reproductive_system0.84981590
105MP0005058_abnormal_lysosome_morphology0.84555114
106MP0001299_abnormal_eye_distance/0.83633047
107MP0005448_abnormal_energy_balance0.83132238
108MP0003718_maternal_effect0.83088501
109MP0005389_reproductive_system_phenotype0.82219878
110MP0008872_abnormal_physiological_respon0.80217440
111MP0005085_abnormal_gallbladder_physiolo0.79473631
112MP0001727_abnormal_embryo_implantation0.79157433
113MP0005257_abnormal_intraocular_pressure0.78707536
114MP0000367_abnormal_coat/_hair0.77539373
115MP0002060_abnormal_skin_morphology0.77018315
116MP0003941_abnormal_skin_development0.76126560
117MP0003122_maternal_imprinting0.74688347
118MP0001764_abnormal_homeostasis0.73889125
119MP0002822_catalepsy0.73444553
120MP0003943_abnormal_hepatobiliary_system0.72892940
121MP0000647_abnormal_sebaceous_gland0.72026782
122MP0002139_abnormal_hepatobiliary_system0.71082838
123MP0000579_abnormal_nail_morphology0.71072499
124MP0005375_adipose_tissue_phenotype0.71063379
125MP0003787_abnormal_imprinting0.69857277
126MP0003172_abnormal_lysosome_physiology0.69353836
127MP0003890_abnormal_embryonic-extraembry0.65484449
128MP0006054_spinal_hemorrhage0.65338697
129MP0010678_abnormal_skin_adnexa0.60729027
130MP0003795_abnormal_bone_structure0.60632726
131MP0001919_abnormal_reproductive_system0.59628937
132MP0002118_abnormal_lipid_homeostasis0.59517373
133MP0000631_abnormal_neuroendocrine_gland0.59152671
134MP0005253_abnormal_eye_physiology0.55535916
135MP0005535_abnormal_body_temperature0.55117998
136MP0005367_renal/urinary_system_phenotyp0.54919246
137MP0000516_abnormal_urinary_system0.54919246
138MP0005381_digestive/alimentary_phenotyp0.54440437
139MP0000372_irregular_coat_pigmentation0.53952460
140MP0003879_abnormal_hair_cell0.52069775
141MP0005187_abnormal_penis_morphology0.51892412
142MP0005334_abnormal_fat_pad0.51325132

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)5.31246106
2Symptomatic seizures (HP:0011145)5.29163928
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.21716986
4Hypoglycemic seizures (HP:0002173)4.93855322
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.42857493
6Chronic bronchitis (HP:0004469)4.42232675
7Insulin-resistant diabetes mellitus (HP:0000831)4.29026279
8Hyperglycemia (HP:0003074)4.13419994
9Absent/shortened dynein arms (HP:0200106)4.07073863
10Dynein arm defect of respiratory motile cilia (HP:0012255)4.07073863
11Abnormality of the intrinsic pathway (HP:0010989)3.88912967
12Abnormality of calcium-phosphate metabolism (HP:0100530)3.76265594
13Abnormal respiratory motile cilium physiology (HP:0012261)3.61312695
14Hypoglycemic coma (HP:0001325)3.61108425
15Decreased circulating renin level (HP:0003351)3.47640874
16Abnormal pancreas size (HP:0012094)3.46506909
17Septate vagina (HP:0001153)3.40402866
18Large for gestational age (HP:0001520)3.26682696
19Hypokinesia (HP:0002375)3.26297459
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.24543155
21Hypoplasia of the fovea (HP:0007750)3.24543155
22Abnormality of the pancreatic islet cells (HP:0006476)3.14232763
23Abnormality of endocrine pancreas physiology (HP:0012093)3.14232763
24Abnormal ciliary motility (HP:0012262)3.07688508
25Abnormal protein glycosylation (HP:0012346)3.04499038
26Abnormal glycosylation (HP:0012345)3.04499038
27Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.04499038
28Abnormal protein N-linked glycosylation (HP:0012347)3.04499038
29Pancreatic islet-cell hyperplasia (HP:0004510)3.01976666
30Hypothermia (HP:0002045)2.99489467
31Hyperphosphatemia (HP:0002905)2.94183266
32Concave nail (HP:0001598)2.92820945
33Conjugated hyperbilirubinemia (HP:0002908)2.92731062
34Amelogenesis imperfecta (HP:0000705)2.88371194
35Rhinitis (HP:0012384)2.81826421
36Abnormal respiratory motile cilium morphology (HP:0005938)2.78430796
37Abnormal respiratory epithelium morphology (HP:0012253)2.78430796
38Enlarged penis (HP:0000040)2.78308238
39Tubulointerstitial nephritis (HP:0001970)2.76483381
40Abnormality of the fovea (HP:0000493)2.76174493
41Ketosis (HP:0001946)2.76117036
42Retinal atrophy (HP:0001105)2.73093635
43Hyperactive renin-angiotensin system (HP:0000841)2.68147909
44Hypoplasia of dental enamel (HP:0006297)2.65230884
45Ocular albinism (HP:0001107)2.64303432
46Infertility (HP:0000789)2.63759137
47Breast carcinoma (HP:0003002)2.62978852
48Hyperkalemia (HP:0002153)2.61419369
49Lip pit (HP:0100267)2.60136488
50Double outlet right ventricle (HP:0001719)2.59592572
51Congenital malformation of the right heart (HP:0011723)2.59592572
52Hypokalemia (HP:0002900)2.58973052
53Tongue fasciculations (HP:0001308)2.57328158
54Type I transferrin isoform profile (HP:0003642)2.57080422
55Hyperparathyroidism (HP:0000843)2.56132947
56Testicular neoplasm (HP:0010788)2.54458510
57Late onset (HP:0003584)2.53942214
58J-shaped sella turcica (HP:0002680)2.53470710
59Abnormality of chloride homeostasis (HP:0011422)2.52295005
60Ketoacidosis (HP:0001993)2.50297413
61Cortical visual impairment (HP:0100704)2.47526216
62Vascular calcification (HP:0004934)2.46904032
63Abdominal distention (HP:0003270)2.46529220
64Unilateral renal agenesis (HP:0000122)2.43300211
65Flat capital femoral epiphysis (HP:0003370)2.43067440
66Exocrine pancreatic insufficiency (HP:0001738)2.42018306
67Diminished movement (HP:0002374)2.39015802
68Abnormality of potassium homeostasis (HP:0011042)2.37006576
69Dysostosis multiplex (HP:0000943)2.36653127
70Cystic liver disease (HP:0006706)2.36523230
71Patchy hypopigmentation of hair (HP:0011365)2.34685499
72Vacuolated lymphocytes (HP:0001922)2.32776667
73Male infertility (HP:0003251)2.28996478
74Aplasia/Hypoplasia of the macula (HP:0008059)2.28443970
75Aplasia/Hypoplasia affecting the retina (HP:0008061)2.27873670
76Abnormality of renin-angiotensin system (HP:0000847)2.27666988
77White forelock (HP:0002211)2.27635219
78Insulin resistance (HP:0000855)2.26884405
79Gout (HP:0001997)2.26634780
80Germ cell neoplasia (HP:0100728)2.25162916
81Generalized aminoaciduria (HP:0002909)2.25070345
82Iris hypopigmentation (HP:0007730)2.24906164
83Chronic hepatic failure (HP:0100626)2.24833993
84Generalized hypopigmentation (HP:0007513)2.24324383
85Right ventricular cardiomyopathy (HP:0011663)2.23363390
86Abnormality of cochlea (HP:0000375)2.20889182
87Bronchiectasis (HP:0002110)2.20738467
88Osteomalacia (HP:0002749)2.19973314
89Urinary glycosaminoglycan excretion (HP:0003541)2.18989643
90Mucopolysacchariduria (HP:0008155)2.18989643
91Macroorchidism (HP:0000053)2.12560468
92Protuberant abdomen (HP:0001538)2.11485085
93Albinism (HP:0001022)2.11191851
94Abnormality of the renal cortex (HP:0011035)2.10393581
95Absent eyebrow (HP:0002223)2.10290909
96Hamartoma of the eye (HP:0010568)2.09674812
97Agitation (HP:0000713)2.09026978
98Abnormality of the renal medulla (HP:0100957)2.08701329
99Abnormality of polysaccharide metabolism (HP:0011012)2.06421631
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06421631
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06421631
102Congenital sensorineural hearing impairment (HP:0008527)2.06171174
103Curly hair (HP:0002212)2.04233054
104Testicular atrophy (HP:0000029)2.01645992
105Blue irides (HP:0000635)1.98768923
106Medial flaring of the eyebrow (HP:0010747)1.98584788
107Nephronophthisis (HP:0000090)1.97397545
108Conjunctival hamartoma (HP:0100780)1.96955027
109Abnormality of nail color (HP:0100643)1.96303429
110Muscle fibrillation (HP:0010546)1.95929620
111Onycholysis (HP:0001806)1.94801196
112Abnormality of midbrain morphology (HP:0002418)1.94215056
113Molar tooth sign on MRI (HP:0002419)1.94215056
114Occipital encephalocele (HP:0002085)1.94046947
115Papillary thyroid carcinoma (HP:0002895)1.93992881
116Disproportionate short-trunk short stature (HP:0003521)1.93488652
117Hypomagnesemia (HP:0002917)1.93308093
118Villous atrophy (HP:0011473)1.91984341
119Abnormality of small intestinal villus morphology (HP:0011472)1.91984341
120Sparse lateral eyebrow (HP:0005338)1.90097205
121Proximal tubulopathy (HP:0000114)1.89288621
122Abnormality of urine glucose concentration (HP:0011016)1.89229211
123Glycosuria (HP:0003076)1.89229211
124Bronchitis (HP:0012387)1.89210355
125Tubular atrophy (HP:0000092)1.89131828
126Progressive sensorineural hearing impairment (HP:0000408)1.88977535
127Cardiovascular calcification (HP:0011915)1.88802814
128Cutaneous melanoma (HP:0012056)1.87248706
129Glucose intolerance (HP:0000833)1.85951893
130Hypopigmentation of the fundus (HP:0007894)1.85674098
131Hypotension (HP:0002615)1.85255792
132Abnormality of aromatic amino acid family metabolism (HP:0004338)1.84272970
133Dysautonomia (HP:0002459)1.84170622
134Hyperthyroidism (HP:0000836)1.83553119
135Goiter (HP:0000853)1.83205006
136Nephropathy (HP:0000112)1.82508583
137Abnormality of magnesium homeostasis (HP:0004921)1.81969651
138Fat malabsorption (HP:0002630)1.81851339
139Tubulointerstitial abnormality (HP:0001969)1.81293420
140Abnormality of vitamin metabolism (HP:0100508)1.80434183
141Pancreatic fibrosis (HP:0100732)1.80116137
142Hyponatremia (HP:0002902)1.79856205
143Congenital ichthyosiform erythroderma (HP:0007431)1.79767763
144Flattened epiphyses (HP:0003071)1.79311438
145Abnormality of the pons (HP:0007361)1.79260269
146Abnormality of vitamin B metabolism (HP:0004340)1.77981500
147Cone-rod dystrophy (HP:0000548)1.76100646
148Renal salt wasting (HP:0000127)1.75624214
149Microretrognathia (HP:0000308)1.74337203
150Congenital glaucoma (HP:0001087)1.72951157
151Steatorrhea (HP:0002570)1.72481811

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR6.81886756
2FRK3.74205125
3PRKD33.16386679
4MAPK153.15265239
5IRAK33.10604196
6STK38L2.87212372
7PASK2.82102809
8TAOK32.74319803
9AKT32.70443136
10MUSK2.43507796
11PKN22.41931705
12TESK12.34217745
13WNK42.23833014
14PDK32.20043119
15PDK42.20043119
16MAP3K22.19941420
17IRAK12.12141783
18RPS6KB21.97324890
19PDK21.84620301
20ERN11.80967276
21ACVR1B1.80600673
22FGFR21.75150384
23PTK61.70629997
24FLT31.69794833
25HIPK21.68583649
26MAP3K121.59185141
27STK241.56992505
28EPHA21.54494805
29EIF2AK11.51908052
30WEE11.50457174
31MAP2K21.46896008
32FER1.42354899
33EIF2AK31.26136051
34EPHA31.23833191
35IRAK41.18373839
36GRK11.16262794
37SIK11.15578179
38MAP3K41.11252805
39IRAK21.07107659
40ZAK1.02863859
41GRK61.02314838
42MST1R0.98019755
43TRIM280.97761116
44CDC42BPA0.96998471
45MST40.96485312
46MAP3K30.95148995
47PIK3CG0.93430904
48NUAK10.90676373
49MAP3K10.90235809
50PAK30.89101146
51MAP3K140.88821732
52WNK10.88544670
53FGFR30.86884691
54WNK30.86447670
55CDK120.86271557
56PHKG20.83648003
57PHKG10.83648003
58MET0.80661374
59RPS6KA20.80286034
60SGK20.79125807
61FGFR40.79092579
62PINK10.78645176
63DYRK1B0.78538188
64NTRK10.78429464
65LMTK20.78201950
66CDK70.77628896
67BCKDK0.76916779
68EEF2K0.75551704
69BMPR1B0.75547186
70PNCK0.73328842
71LATS10.73087788
72OXSR10.72670827
73SCYL20.72542332
74PTK20.72325967
75NME20.72060533
76CAMKK20.71332388
77MYLK0.69422106
78CHUK0.68374775
79STK30.68315897
80MAP2K70.67981902
81TRIB30.66160186
82ADRBK20.65607872
83NEK60.64513374
84PRKCE0.64458962
85RIPK10.63136534
86PRKAA10.62990038
87MAPKAPK30.60432905
88SIK30.59037159
89BMPR20.57985622
90PIK3CA0.57531801
91NLK0.56885617
92TAOK10.56627689
93RPS6KB10.56615182
94BRAF0.55813143
95PRKCI0.55330499
96SGK4940.53941704
97SGK2230.53941704
98MAP4K20.53196851
99ILK0.52371412
100NME10.50656654
101MATK0.49436626
102CSNK1G10.49257434
103JAK30.47390407
104PTK2B0.46895643
105STK380.46478515
106JAK10.46373743
107AKT20.46316933
108PAK40.46270312
109STK160.45943002
110DYRK30.45853753
111MAP2K10.44943394
112RET0.42786188
113PRKG20.42773321
114CAMK2D0.41989686
115CSNK1G30.41157475
116TNK20.40882460
117JAK20.40687127
118ERBB20.39626524
119BRSK20.38523923
120BRSK10.37464968
121SGK30.35967952
122ZAP700.35306063
123NTRK30.35142270
124PRKAA20.34764132
125PDGFRA0.34024801
126TRPM70.34023932
127MTOR0.33832766
128CSNK1A10.33526418
129CASK0.33513596
130ERBB30.32958944
131EPHB10.32785504
132MARK30.32098782
133MAP3K90.32090910
134CAMKK10.30400876
135STK390.29637990
136PDK10.29348858
137PRKCH0.29131648
138PDPK10.27392095
139GSK3A0.26077960
140CAMK1D0.24816092
141MAP2K60.24534153

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.40186894
2Protein export_Homo sapiens_hsa030605.49021457
3Sulfur metabolism_Homo sapiens_hsa009203.85838289
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.66564355
5Insulin secretion_Homo sapiens_hsa049112.63614664
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.44502954
7N-Glycan biosynthesis_Homo sapiens_hsa005102.28669689
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.13528508
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.12037252
10Pancreatic secretion_Homo sapiens_hsa049722.11607075
11Butanoate metabolism_Homo sapiens_hsa006502.07276318
12Vibrio cholerae infection_Homo sapiens_hsa051102.02637523
13Selenocompound metabolism_Homo sapiens_hsa004501.93637965
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.92334538
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84870726
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76160979
17Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.76052976
18Fatty acid elongation_Homo sapiens_hsa000621.75766142
19Vitamin B6 metabolism_Homo sapiens_hsa007501.74927514
20Glutathione metabolism_Homo sapiens_hsa004801.71665588
21Carbohydrate digestion and absorption_Homo sapiens_hsa049731.63973580
22Chemical carcinogenesis_Homo sapiens_hsa052041.63191256
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58659054
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57187559
25Other glycan degradation_Homo sapiens_hsa005111.55427869
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49998123
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48385849
28Fat digestion and absorption_Homo sapiens_hsa049751.45581497
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38863660
30Type II diabetes mellitus_Homo sapiens_hsa049301.38763958
31Protein digestion and absorption_Homo sapiens_hsa049741.37494476
32beta-Alanine metabolism_Homo sapiens_hsa004101.37254581
33Linoleic acid metabolism_Homo sapiens_hsa005911.34131228
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32882221
35Collecting duct acid secretion_Homo sapiens_hsa049661.31801015
36Type I diabetes mellitus_Homo sapiens_hsa049401.30301159
37Nitrogen metabolism_Homo sapiens_hsa009101.29671294
38Fructose and mannose metabolism_Homo sapiens_hsa000511.27424749
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.27285382
40Fatty acid metabolism_Homo sapiens_hsa012121.26799516
41Fatty acid degradation_Homo sapiens_hsa000711.22953479
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.20285200
43Folate biosynthesis_Homo sapiens_hsa007901.19338270
44Lysosome_Homo sapiens_hsa041421.16786016
45Peroxisome_Homo sapiens_hsa041461.15368485
46Caffeine metabolism_Homo sapiens_hsa002321.11215094
47Primary bile acid biosynthesis_Homo sapiens_hsa001201.07949465
48Tight junction_Homo sapiens_hsa045301.06579722
49Arginine biosynthesis_Homo sapiens_hsa002201.05790270
50Mineral absorption_Homo sapiens_hsa049781.05677145
51Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04835556
52Cocaine addiction_Homo sapiens_hsa050301.04503673
53Thyroid hormone synthesis_Homo sapiens_hsa049181.00314850
54Sphingolipid metabolism_Homo sapiens_hsa006000.99378919
55Arginine and proline metabolism_Homo sapiens_hsa003300.95671895
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95647997
57Prolactin signaling pathway_Homo sapiens_hsa049170.95143779
58Taste transduction_Homo sapiens_hsa047420.94907387
59Retinol metabolism_Homo sapiens_hsa008300.93266603
60Glucagon signaling pathway_Homo sapiens_hsa049220.91960357
61Circadian rhythm_Homo sapiens_hsa047100.91706668
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89490030
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88726336
64Dorso-ventral axis formation_Homo sapiens_hsa043200.86857267
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85285640
66Galactose metabolism_Homo sapiens_hsa000520.84163690
67ABC transporters_Homo sapiens_hsa020100.83553082
68Oxidative phosphorylation_Homo sapiens_hsa001900.81262081
69Bile secretion_Homo sapiens_hsa049760.80159919
70Amphetamine addiction_Homo sapiens_hsa050310.79207631
71Insulin resistance_Homo sapiens_hsa049310.79093247
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77028737
73mTOR signaling pathway_Homo sapiens_hsa041500.75292735
74Sulfur relay system_Homo sapiens_hsa041220.73516852
75Synaptic vesicle cycle_Homo sapiens_hsa047210.71374680
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68612333
77Inositol phosphate metabolism_Homo sapiens_hsa005620.67680678
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66977376
79Vitamin digestion and absorption_Homo sapiens_hsa049770.65154105
80Pentose phosphate pathway_Homo sapiens_hsa000300.64694658
81Glycerolipid metabolism_Homo sapiens_hsa005610.62832208
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.62156729
83Starch and sucrose metabolism_Homo sapiens_hsa005000.61094512
84Regulation of autophagy_Homo sapiens_hsa041400.60488944
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58858314
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57698512
87Histidine metabolism_Homo sapiens_hsa003400.56926493
88Ether lipid metabolism_Homo sapiens_hsa005650.54648931
89Antigen processing and presentation_Homo sapiens_hsa046120.54648830
90Legionellosis_Homo sapiens_hsa051340.54140319
91Proteasome_Homo sapiens_hsa030500.53198780
92Phenylalanine metabolism_Homo sapiens_hsa003600.52632319
93Tryptophan metabolism_Homo sapiens_hsa003800.52221003
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.51223659
95Arachidonic acid metabolism_Homo sapiens_hsa005900.48399851
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47665273
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46811720
98Prostate cancer_Homo sapiens_hsa052150.46688777
99Fatty acid biosynthesis_Homo sapiens_hsa000610.45800987
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44924692
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43892730
102Renin secretion_Homo sapiens_hsa049240.42591027
103Estrogen signaling pathway_Homo sapiens_hsa049150.41882175
104Huntingtons disease_Homo sapiens_hsa050160.41118785
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.40800350
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40477873
107Pyruvate metabolism_Homo sapiens_hsa006200.39884314
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39687934
109Renin-angiotensin system_Homo sapiens_hsa046140.39378350
110Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38398351
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36711173
112Tyrosine metabolism_Homo sapiens_hsa003500.33458868
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.30051876
114Cholinergic synapse_Homo sapiens_hsa047250.29932219
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29568596
116Rheumatoid arthritis_Homo sapiens_hsa053230.27303397
117Serotonergic synapse_Homo sapiens_hsa047260.26118850
118Phagosome_Homo sapiens_hsa041450.26001526
119Toxoplasmosis_Homo sapiens_hsa051450.24859962
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24678037
121Hepatitis C_Homo sapiens_hsa051600.24467088
122Metabolic pathways_Homo sapiens_hsa011000.23196081
123Propanoate metabolism_Homo sapiens_hsa006400.23087724
124Circadian entrainment_Homo sapiens_hsa047130.22915069
125Insulin signaling pathway_Homo sapiens_hsa049100.22194288
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.21828685
127TNF signaling pathway_Homo sapiens_hsa046680.21696868
128Endometrial cancer_Homo sapiens_hsa052130.21474982
129Dopaminergic synapse_Homo sapiens_hsa047280.21220820
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21191569
131AMPK signaling pathway_Homo sapiens_hsa041520.21159551
132Thyroid cancer_Homo sapiens_hsa052160.19546946
133cAMP signaling pathway_Homo sapiens_hsa040240.18877098
134Bladder cancer_Homo sapiens_hsa052190.16564499
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15368090
136Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14325779
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.13839737
138Ovarian steroidogenesis_Homo sapiens_hsa049130.13478135
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13448066

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