TTC39B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to interleukin-15 (GO:0070672)4.20366013
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.15043840
3negative regulation of cell killing (GO:0031342)4.15043840
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.04251765
5regulation of isotype switching to IgG isotypes (GO:0048302)3.84519564
6cellular response to interleukin-15 (GO:0071350)3.77665861
7positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.72755242
8tryptophan catabolic process (GO:0006569)3.69040910
9indole-containing compound catabolic process (GO:0042436)3.69040910
10indolalkylamine catabolic process (GO:0046218)3.69040910
11fucose catabolic process (GO:0019317)3.55814246
12L-fucose metabolic process (GO:0042354)3.55814246
13L-fucose catabolic process (GO:0042355)3.55814246
14negative thymic T cell selection (GO:0045060)3.54532872
15negative T cell selection (GO:0043383)3.53772540
16kynurenine metabolic process (GO:0070189)3.47895499
17regulation of regulatory T cell differentiation (GO:0045589)3.37230592
18behavioral response to nicotine (GO:0035095)3.33385233
19positive regulation of gamma-delta T cell activation (GO:0046645)3.30349351
20indolalkylamine metabolic process (GO:0006586)3.29189663
21COPI coating of Golgi vesicle (GO:0048205)3.25442945
22Golgi transport vesicle coating (GO:0048200)3.25442945
23interferon-gamma production (GO:0032609)3.22086454
24positive T cell selection (GO:0043368)3.15632956
25activated T cell proliferation (GO:0050798)3.12154578
26protein targeting to Golgi (GO:0000042)3.11777338
27thymic T cell selection (GO:0045061)3.07278828
28tryptophan metabolic process (GO:0006568)3.05688120
29regulation of T cell tolerance induction (GO:0002664)3.05227210
30positive thymic T cell selection (GO:0045059)3.04811494
31T cell selection (GO:0045058)3.02857633
32JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.01780556
33regulation of gamma-delta T cell differentiation (GO:0045586)2.95358325
34regulation of cholesterol homeostasis (GO:2000188)2.91418752
35establishment of protein localization to Golgi (GO:0072600)2.90172004
36positive regulation of humoral immune response (GO:0002922)2.89716812
37antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.89301105
38antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.89301105
39tolerance induction (GO:0002507)2.88600446
40detection of light stimulus involved in sensory perception (GO:0050962)2.84816608
41detection of light stimulus involved in visual perception (GO:0050908)2.84816608
42tyrosine phosphorylation of STAT protein (GO:0007260)2.84179992
43regulation of transforming growth factor beta1 production (GO:0032908)2.82615914
44protein K11-linked deubiquitination (GO:0035871)2.81268987
45dicarboxylic acid biosynthetic process (GO:0043650)2.80601133
46regulation of interleukin-12 biosynthetic process (GO:0045075)2.77396545
47phosphatidylinositol acyl-chain remodeling (GO:0036149)2.77253449
48negative regulation of systemic arterial blood pressure (GO:0003085)2.73263956
49T-helper cell differentiation (GO:0042093)2.71528695
50CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.71528695
51regulation of memory T cell differentiation (GO:0043380)2.68564211
52cellular response to ethanol (GO:0071361)2.68200769
53positive regulation of natural killer cell mediated immunity (GO:0002717)2.67502798
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.67502798
55regulation of gamma-delta T cell activation (GO:0046643)2.67446340
56positive regulation of cAMP-mediated signaling (GO:0043950)2.67402299
57growth hormone receptor signaling pathway (GO:0060396)2.65783309
58regulation of alpha-beta T cell proliferation (GO:0046640)2.65502987
59regulation of interleukin-2 biosynthetic process (GO:0045076)2.64875750
60regulation of natural killer cell mediated immunity (GO:0002715)2.63568012
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.63568012
62antigen processing and presentation of endogenous antigen (GO:0019883)2.63459016
63positive regulation of immunoglobulin mediated immune response (GO:0002891)2.61149596
64positive regulation of B cell mediated immunity (GO:0002714)2.61149596
65positive regulation of alpha-beta T cell proliferation (GO:0046641)2.60403963
66amine catabolic process (GO:0009310)2.60308326
67cellular biogenic amine catabolic process (GO:0042402)2.60308326
68positive regulation of isotype switching (GO:0045830)2.59563814
69positive regulation of defense response to virus by host (GO:0002230)2.58551478
70cellular response to ATP (GO:0071318)2.58394908
71indole-containing compound metabolic process (GO:0042430)2.57955622
72regulation of immunoglobulin secretion (GO:0051023)2.56527043
73positive regulation of natural killer cell differentiation (GO:0032825)2.55868194
74T cell costimulation (GO:0031295)2.55118811
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.52752178
76negative regulation of T cell mediated immunity (GO:0002710)2.52659405
77positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.52247338
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.50995895
79regulation of translation, ncRNA-mediated (GO:0045974)2.50995895
80negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50995895
81lymphocyte costimulation (GO:0031294)2.50093793
82positive regulation of interleukin-2 production (GO:0032743)2.49527562
83sulfation (GO:0051923)2.49457123
84L-alpha-amino acid transmembrane transport (GO:1902475)2.47851400
85protein carboxylation (GO:0018214)2.47271720
86peptidyl-glutamic acid carboxylation (GO:0017187)2.47271720
87retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.46800784
88retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46594413
89regulation of T-helper 1 cell differentiation (GO:0045625)2.45399705
90T cell differentiation involved in immune response (GO:0002292)2.43344625
91alpha-beta T cell differentiation involved in immune response (GO:0002293)2.43344625
92alpha-beta T cell activation involved in immune response (GO:0002287)2.43344625
93negative regulation of protein oligomerization (GO:0032460)2.43299566
94negative regulation of bone resorption (GO:0045779)2.41682078
95regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41500238
96adaptation of signaling pathway (GO:0023058)2.41333502
97cAMP catabolic process (GO:0006198)2.40322565
98proline transport (GO:0015824)2.39943789
99phosphatidylserine acyl-chain remodeling (GO:0036150)2.39823106
100neural tube formation (GO:0001841)2.38799044
101negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.38172961
102negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38098107
103negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.37699684
104negative regulation of T-helper cell differentiation (GO:0045623)2.37699684
105detection of calcium ion (GO:0005513)2.37635011
106COPII vesicle coating (GO:0048208)2.37108029
107positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.36358342
108serotonin metabolic process (GO:0042428)2.35418949
109lipid translocation (GO:0034204)2.35105286
110phospholipid translocation (GO:0045332)2.35105286
111superoxide anion generation (GO:0042554)2.34942630
112endoderm formation (GO:0001706)2.34934149
113thyroid hormone metabolic process (GO:0042403)2.34639610
114regulation of isotype switching (GO:0045191)2.34477740
115NAD biosynthetic process (GO:0009435)2.33582824
116cyclic nucleotide catabolic process (GO:0009214)2.33561378
117insulin secretion (GO:0030073)2.33035356
118positive regulation of vesicle fusion (GO:0031340)2.31058515
119regulation of MHC class I biosynthetic process (GO:0045343)2.30872780
120regulation of beta-amyloid formation (GO:1902003)2.30867890
121regulation of T-helper 1 type immune response (GO:0002825)2.29543133
122regulation of mesoderm development (GO:2000380)2.29142104
123regulation of ARF protein signal transduction (GO:0032012)2.28844303
124alpha-beta T cell differentiation (GO:0046632)2.28232831
125thrombin receptor signaling pathway (GO:0070493)2.27662375
126regulation of leukocyte mediated cytotoxicity (GO:0001910)2.27438125
127negative regulation of mast cell activation (GO:0033004)2.26880326
128keratinization (GO:0031424)2.26796063
129primary amino compound metabolic process (GO:1901160)2.26058477
130positive regulation of T-helper 1 type immune response (GO:0002827)2.25677928
131CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.25533088
132regulation of chronic inflammatory response (GO:0002676)2.25287241
133regulation of B cell receptor signaling pathway (GO:0050855)2.25122231
134response to pheromone (GO:0019236)2.24623228
135photoreceptor cell maintenance (GO:0045494)2.24120636
136synaptic vesicle maturation (GO:0016188)2.23943080
137signal peptide processing (GO:0006465)2.22946918
138regulation of immunoglobulin mediated immune response (GO:0002889)2.22814556
139phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.22516620
140cellular zinc ion homeostasis (GO:0006882)2.20813337
141regulation of response to tumor cell (GO:0002834)2.20614421
142positive regulation of response to tumor cell (GO:0002836)2.20614421
143positive regulation of immune response to tumor cell (GO:0002839)2.20614421
144regulation of immune response to tumor cell (GO:0002837)2.20614421
145DNA deamination (GO:0045006)2.20532673
146positive regulation of DNA recombination (GO:0045911)2.19874860
147positive regulation of immunoglobulin production (GO:0002639)2.19823923
148positive regulation of histone deacetylation (GO:0031065)2.19712519
149cerebellar Purkinje cell differentiation (GO:0021702)2.18990797
150T cell migration (GO:0072678)2.18762075
151positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.18748885
152neuronal action potential (GO:0019228)2.18741292
153negative regulation of interleukin-1 beta production (GO:0032691)2.18720361
154peptide hormone processing (GO:0016486)2.18333516
155alpha-beta T cell activation (GO:0046631)2.17648853
156magnesium ion transport (GO:0015693)2.17454743
157cellular response to growth hormone stimulus (GO:0071378)2.17135310
158kidney morphogenesis (GO:0060993)2.14169726
159parturition (GO:0007567)2.13948599
160benzene-containing compound metabolic process (GO:0042537)2.12650707
161cilium or flagellum-dependent cell motility (GO:0001539)2.12135028
162aromatic amino acid family catabolic process (GO:0009074)2.10936180
163detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.10878014
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.10355379
165phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.09034354
166positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.07629791
167regulation of macrophage derived foam cell differentiation (GO:0010743)2.07603399
168protein K48-linked deubiquitination (GO:0071108)2.07446036
169regulation of establishment of cell polarity (GO:2000114)2.07361446
170cellular response to exogenous dsRNA (GO:0071360)2.06822995
171regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.05632720
172regulation of T cell mediated cytotoxicity (GO:0001914)2.05412632
173keratinocyte development (GO:0003334)2.04737842
174dopamine transport (GO:0015872)2.04250122
175negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.03689368
176cellular ketone body metabolic process (GO:0046950)2.03351974
177protein K63-linked deubiquitination (GO:0070536)2.03236274
178sphingoid metabolic process (GO:0046519)2.03032291
179multicellular organism reproduction (GO:0032504)2.02454217
180negative regulation of lipid storage (GO:0010888)2.00914299
181negative regulation of interleukin-1 production (GO:0032692)2.00262217
182platelet dense granule organization (GO:0060155)1.99707460
183positive regulation of fatty acid transport (GO:2000193)1.99606921
1843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)1.98440928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.69539615
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00190864
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.16482139
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90865004
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.81739341
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77630614
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53804916
8VDR_22108803_ChIP-Seq_LS180_Human2.40262295
9RUNX_20019798_ChIP-Seq_JUKART_Human2.37069516
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.36881640
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.34463378
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.31626375
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23684323
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15152043
15* RXR_22158963_ChIP-Seq_LIVER_Mouse2.03973098
16BP1_19119308_ChIP-ChIP_Hs578T_Human1.95905595
17* LXR_22158963_ChIP-Seq_LIVER_Mouse1.95658421
18ZNF274_21170338_ChIP-Seq_K562_Hela1.90512826
19ZNF217_24962896_ChIP-Seq_MCF-7_Human1.80959511
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.68710564
21IGF1R_20145208_ChIP-Seq_DFB_Human1.67904108
22ER_23166858_ChIP-Seq_MCF-7_Human1.65303889
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.65249221
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.64980317
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59061815
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59034586
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55421661
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51120411
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49347575
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47450993
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.47359349
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45904705
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45592582
34* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43862003
35GBX2_23144817_ChIP-Seq_PC3_Human1.40617903
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.39906614
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38514685
38AR_25329375_ChIP-Seq_VCAP_Human1.37794175
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37564071
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37229529
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36018420
42RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.35192015
43FUS_26573619_Chip-Seq_HEK293_Human1.34290788
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33533139
45* MYB_26560356_Chip-Seq_TH2_Human1.33074663
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33007153
47* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32284046
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31488966
49* PRDM14_20953172_ChIP-Seq_ESCs_Human1.30287256
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.29652286
51BCAT_22108803_ChIP-Seq_LS180_Human1.28741376
52DROSHA_22980978_ChIP-Seq_HELA_Human1.27000391
53NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25879199
54EWS_26573619_Chip-Seq_HEK293_Human1.25519454
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25473873
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.25452160
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22802499
58CRX_20693478_ChIP-Seq_RETINA_Mouse1.22421794
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22011082
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.21626251
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21122462
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21101361
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21101361
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20564601
65TP53_16413492_ChIP-PET_HCT116_Human1.20422806
66PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19463758
67FLI1_21867929_ChIP-Seq_TH2_Mouse1.19346355
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19197152
69* GATA3_27048872_Chip-Seq_THYMUS_Human1.19181248
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.18638857
71CBP_20019798_ChIP-Seq_JUKART_Human1.18047904
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18047904
73* P53_22387025_ChIP-Seq_ESCs_Mouse1.17866218
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.17799999
75* SMAD4_21741376_ChIP-Seq_EPCs_Human1.17206490
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.16634660
77ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15909877
78* MYB_26560356_Chip-Seq_TH1_Human1.15018068
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.14877166
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14794602
81STAT3_23295773_ChIP-Seq_U87_Human1.14544263
82FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13855755
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13650533
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12432824
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.11515057
86RXR_22108803_ChIP-Seq_LS180_Human1.11421785
87EZH2_22144423_ChIP-Seq_EOC_Human1.10574772
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10286783
89* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09982189
90FOXA2_19822575_ChIP-Seq_HepG2_Human1.09374320
91SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.08681455
92GATA1_22025678_ChIP-Seq_K562_Human1.08567032
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08343260
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.07845395
95NANOG_19829295_ChIP-Seq_ESCs_Human1.07441993
96SOX2_19829295_ChIP-Seq_ESCs_Human1.07441993
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06621784
98NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06180591
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06180591
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05550161
101* RUNX2_22187159_ChIP-Seq_PCA_Human1.04324754
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04163367
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03566792
104VDR_24787735_ChIP-Seq_THP-1_Human1.03283972
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02491749
106KDM2B_26808549_Chip-Seq_REH_Human1.01186648
107P300_18555785_Chip-Seq_ESCs_Mouse1.00982276
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99763528
109TAF15_26573619_Chip-Seq_HEK293_Human0.99453125
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95252274
111SOX2_21211035_ChIP-Seq_LN229_Gbm0.94208178
112TP53_18474530_ChIP-ChIP_U2OS_Human0.93445862
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.93152739
114GATA3_26560356_Chip-Seq_TH2_Human0.93035676
115IRF8_21731497_ChIP-ChIP_J774_Mouse0.92846817
116RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92023447
117* TP63_23658742_ChIP-Seq_EP156T_Human0.90324732
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89086247
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87615075
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.87453797
121AR_21572438_ChIP-Seq_LNCaP_Human0.87109763
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86887842
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86567340
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.85743836
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.85623036
126TCF4_22108803_ChIP-Seq_LS180_Human0.84780155
127STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84246304
128SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84188203
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84036224
130NANOG_18555785_Chip-Seq_ESCs_Mouse0.83247167
131* REST_21632747_ChIP-Seq_MESCs_Mouse0.81152649
132AR_19668381_ChIP-Seq_PC3_Human0.81033683
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.80785456
134TCF4_23295773_ChIP-Seq_U87_Human0.80546479
135MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.80096403
136* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79960880
137* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.79424248
138CDX2_22108803_ChIP-Seq_LS180_Human0.79264889
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79192950
140E2F1_18555785_Chip-Seq_ESCs_Mouse0.78259641
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78160023
142PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77960496
143CJUN_26792858_Chip-Seq_BT549_Human0.77747383
144TBX3_20139965_ChIP-Seq_ESCs_Mouse0.77312373
145P300_19829295_ChIP-Seq_ESCs_Human0.77239508
146ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76924310
147* AHR_22903824_ChIP-Seq_MCF-7_Human0.76444081
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.76173928
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.76125488
150NMYC_18555785_Chip-Seq_ESCs_Mouse0.75837052
151TCF7_22412390_ChIP-Seq_EML_Mouse0.75542773
152PU_27001747_Chip-Seq_BMDM_Mouse0.74792390
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.74610930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog3.67816625
2MP0003300_gastrointestinal_ulcer3.51529615
3MP0005671_abnormal_response_to2.93629823
4MP0010234_abnormal_vibrissa_follicle2.88680510
5MP0003252_abnormal_bile_duct2.57049364
6MP0005365_abnormal_bile_salt2.47796464
7MP0010352_gastrointestinal_tract_polyps2.40020896
8MP0000013_abnormal_adipose_tissue2.39694759
9MP0009780_abnormal_chondrocyte_physiolo2.38321381
10MP0002139_abnormal_hepatobiliary_system2.37486335
11MP0008875_abnormal_xenobiotic_pharmacok2.34902950
12MP0002693_abnormal_pancreas_physiology2.27982187
13MP0003045_fibrosis2.26543003
14MP0003763_abnormal_thymus_physiology2.17412318
15MP0005085_abnormal_gallbladder_physiolo2.13828427
16MP0002138_abnormal_hepatobiliary_system2.08409369
17MP0005387_immune_system_phenotype2.05292296
18MP0001790_abnormal_immune_system2.05292296
19MP0002909_abnormal_adrenal_gland2.03797528
20MP0003195_calcinosis2.00733155
21MP0004043_abnormal_pH_regulation1.99978251
22MP0000383_abnormal_hair_follicle1.95409412
23MP0005360_urolithiasis1.94991132
24MP0004947_skin_inflammation1.94426875
25MP0003436_decreased_susceptibility_to1.94061206
26MP0006082_CNS_inflammation1.87555178
27MP0003303_peritoneal_inflammation1.84506476
28MP0003866_abnormal_defecation1.81153953
29MP0001835_abnormal_antigen_presentation1.77868873
30MP0003183_abnormal_peptide_metabolism1.76970629
31MP0005000_abnormal_immune_tolerance1.76245423
32MP0000685_abnormal_immune_system1.75462235
33MP0000427_abnormal_hair_cycle1.73084084
34MP0008004_abnormal_stomach_pH1.68128364
35MP0001800_abnormal_humoral_immune1.63446422
36MP0001944_abnormal_pancreas_morphology1.61385622
37MP0002876_abnormal_thyroid_physiology1.61278490
38MP0008961_abnormal_basal_metabolism1.61222151
39MP0005646_abnormal_pituitary_gland1.60808751
40MP0005551_abnormal_eye_electrophysiolog1.60432372
41MP0002638_abnormal_pupillary_reflex1.59734356
42MP0001968_abnormal_touch/_nociception1.57738614
43MP0010678_abnormal_skin_adnexa1.56316337
44MP0008872_abnormal_physiological_respon1.55837196
45MP0001501_abnormal_sleep_pattern1.55031934
46MP0002822_catalepsy1.54742727
47MP0003868_abnormal_feces_composition1.51235519
48MP0004130_abnormal_muscle_cell1.49071929
49MP0004885_abnormal_endolymph1.44202197
50MP0002102_abnormal_ear_morphology1.43395751
51MP0008877_abnormal_DNA_methylation1.43169245
52MP0002837_dystrophic_cardiac_calcinosis1.42908685
53MP0000230_abnormal_systemic_arterial1.42219696
54MP0006054_spinal_hemorrhage1.41684652
55MP0010155_abnormal_intestine_physiology1.41629257
56MP0003705_abnormal_hypodermis_morpholog1.41396011
57MP0003646_muscle_fatigue1.39457764
58MP0002723_abnormal_immune_serum1.38410383
59MP0005310_abnormal_salivary_gland1.38128577
60MP0001485_abnormal_pinna_reflex1.37340061
61MP0005174_abnormal_tail_pigmentation1.35323242
62MP0003724_increased_susceptibility_to1.33140628
63MP0004510_myositis1.30899446
64MP0002928_abnormal_bile_duct1.28875197
65MP0002078_abnormal_glucose_homeostasis1.28823773
66MP0004142_abnormal_muscle_tone1.26973011
67MP0009785_altered_susceptibility_to1.23269980
68MP0002166_altered_tumor_susceptibility1.19626463
69MP0005076_abnormal_cell_differentiation1.18757861
70MP0000609_abnormal_liver_physiology1.18078964
71MP0002006_tumorigenesis1.17825673
72MP0002148_abnormal_hypersensitivity_rea1.17719555
73MP0010329_abnormal_lipoprotein_level1.17713594
74MP0002277_abnormal_respiratory_mucosa1.17150513
75MP0004381_abnormal_hair_follicle1.15686109
76MP0000003_abnormal_adipose_tissue1.14494158
77MP0002452_abnormal_antigen_presenting1.14426430
78MP0002405_respiratory_system_inflammati1.14249228
79MP0001845_abnormal_inflammatory_respons1.12666928
80MP0001984_abnormal_olfaction1.12602681
81MP0005025_abnormal_response_to1.12299093
82MP0001986_abnormal_taste_sensitivity1.11869074
83MP0001819_abnormal_immune_cell1.11626673
84MP0004859_abnormal_synaptic_plasticity1.11553055
85MP0003880_abnormal_central_pattern1.11077613
86MP0003879_abnormal_hair_cell1.10727038
87MP0002420_abnormal_adaptive_immunity1.10481652
88MP0005379_endocrine/exocrine_gland_phen1.10277731
89MP0002736_abnormal_nociception_after1.09829895
90MP0001666_abnormal_nutrient_absorption1.09237947
91MP0002168_other_aberrant_phenotype1.09113131
92MP0003453_abnormal_keratinocyte_physiol1.07381382
93MP0002064_seizures1.07338314
94MP0003011_delayed_dark_adaptation1.04284870
95MP0003191_abnormal_cellular_cholesterol1.02315917
96MP0002272_abnormal_nervous_system1.01309220
97MP0001873_stomach_inflammation0.98593868
98MP0000604_amyloidosis0.98373677
99MP0005535_abnormal_body_temperature0.98335536
100MP0001533_abnormal_skeleton_physiology0.98233213
101MP0003566_abnormal_cell_adhesion0.98075617
102MP0000465_gastrointestinal_hemorrhage0.97826887
103MP0002254_reproductive_system_inflammat0.97450619
104MP0003172_abnormal_lysosome_physiology0.97223786
105MP0005253_abnormal_eye_physiology0.96781099
106MP0004019_abnormal_vitamin_homeostasis0.96722692
107MP0005167_abnormal_blood-brain_barrier0.95967725
108MP0010386_abnormal_urinary_bladder0.94346412
109MP0004742_abnormal_vestibular_system0.93662595
110MP0001919_abnormal_reproductive_system0.93455094
111MP0005448_abnormal_energy_balance0.93305592
112MP0003890_abnormal_embryonic-extraembry0.92814320
113MP0001756_abnormal_urination0.90720378
114MP0003635_abnormal_synaptic_transmissio0.90193926
115MP0005389_reproductive_system_phenotype0.89780666
116MP0001663_abnormal_digestive_system0.88992858
117MP0003638_abnormal_response/metabolism_0.88725838
118MP0002998_abnormal_bone_remodeling0.88513877
119MP0008469_abnormal_protein_level0.86827323
120MP0002398_abnormal_bone_marrow0.86366610
121MP0005023_abnormal_wound_healing0.85898027
122MP0005410_abnormal_fertilization0.85462659
123MP0004270_analgesia0.85194202
124MP0003633_abnormal_nervous_system0.84792242
125MP0005464_abnormal_platelet_physiology0.84520990
126MP0003091_abnormal_cell_migration0.84430532
127MP0004264_abnormal_extraembryonic_tissu0.82959171
128MP0009764_decreased_sensitivity_to0.81730227
129MP0000716_abnormal_immune_system0.80800421
130MP0002419_abnormal_innate_immunity0.80700576
131MP0001664_abnormal_digestion0.80214307
132MP0009046_muscle_twitch0.78738483
133MP0001765_abnormal_ion_homeostasis0.77656515
134MP0000703_abnormal_thymus_morphology0.76089870
135MP0002896_abnormal_bone_mineralization0.76028393
136MP0009333_abnormal_splenocyte_physiolog0.75075719
137MP0009745_abnormal_behavioral_response0.74602256
138MP0003283_abnormal_digestive_organ0.73457903
139MP0009763_increased_sensitivity_to0.73417112
140MP0008569_lethality_at_weaning0.73154532
141MP0000569_abnormal_digit_pigmentation0.72564485
142MP0001299_abnormal_eye_distance/0.71489495
143MP0001881_abnormal_mammary_gland0.71211393
144MP0000858_altered_metastatic_potential0.70482256
145MP0003787_abnormal_imprinting0.69915383
146MP0002118_abnormal_lipid_homeostasis0.69780016

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)3.70959465
2Genetic anticipation (HP:0003743)3.66194736
3Hyperventilation (HP:0002883)3.60522901
4Abnormality of the common coagulation pathway (HP:0010990)3.51534499
5Hypoglycemic seizures (HP:0002173)3.44031792
6T lymphocytopenia (HP:0005403)3.43274190
7Abnormality of T cell number (HP:0011839)3.37714950
8Congenital stationary night blindness (HP:0007642)3.35406164
9Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.29297919
10Progressive cerebellar ataxia (HP:0002073)3.28226260
11Stomach cancer (HP:0012126)3.27745382
12Pancreatic cysts (HP:0001737)3.24888094
13Joint swelling (HP:0001386)3.13074180
14Hyperglycemia (HP:0003074)3.10700223
15Decreased circulating renin level (HP:0003351)3.07357834
16Retrobulbar optic neuritis (HP:0100654)3.03485934
17Optic neuritis (HP:0100653)3.03485934
18Gaze-evoked nystagmus (HP:0000640)3.02633246
19Symptomatic seizures (HP:0011145)3.01973798
20Eczematoid dermatitis (HP:0000976)2.95029814
21Myocardial infarction (HP:0001658)2.87903389
22Abnormality of the renal cortex (HP:0011035)2.84474254
23Intrahepatic cholestasis (HP:0001406)2.84228873
24Congenital sensorineural hearing impairment (HP:0008527)2.83282404
25Stomatitis (HP:0010280)2.81359557
26Pancreatic fibrosis (HP:0100732)2.78358889
27Hypoglycemic coma (HP:0001325)2.73357550
28Arterial thrombosis (HP:0004420)2.70609511
29Orchitis (HP:0100796)2.69953713
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.64002311
31Furrowed tongue (HP:0000221)2.63043768
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.58455139
33Absent/shortened dynein arms (HP:0200106)2.58455139
34Abnormality of midbrain morphology (HP:0002418)2.58436083
35Molar tooth sign on MRI (HP:0002419)2.58436083
36Autoimmune hemolytic anemia (HP:0001890)2.58298684
37True hermaphroditism (HP:0010459)2.57931259
38Myositis (HP:0100614)2.56209778
39Abnormality of the intrinsic pathway (HP:0010989)2.54384933
40Dysmetric saccades (HP:0000641)2.51460352
41Abolished electroretinogram (ERG) (HP:0000550)2.50864918
42Prolonged partial thromboplastin time (HP:0003645)2.49494422
43Abnormality of aromatic amino acid family metabolism (HP:0004338)2.49096415
44Pustule (HP:0200039)2.44970109
45Focal motor seizures (HP:0011153)2.43859597
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.43762454
47Increased IgE level (HP:0003212)2.43482607
48Atonic seizures (HP:0010819)2.43242447
49Hematochezia (HP:0002573)2.42893859
50Insulin-resistant diabetes mellitus (HP:0000831)2.41084705
51Fair hair (HP:0002286)2.40934977
52Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.39953657
53Pulmonary infiltrates (HP:0002113)2.39797944
54Chronic diarrhea (HP:0002028)2.39113224
55Absence seizures (HP:0002121)2.38271093
56Impaired smooth pursuit (HP:0007772)2.35263759
57Clumsiness (HP:0002312)2.34167047
58Gastrointestinal infarctions (HP:0005244)2.32629546
59Parakeratosis (HP:0001036)2.30613149
60Attenuation of retinal blood vessels (HP:0007843)2.30415196
61Inability to walk (HP:0002540)2.29063412
62Hemiplegia (HP:0002301)2.27731738
63Nephronophthisis (HP:0000090)2.27670016
64Abnormality of the renal medulla (HP:0100957)2.27488240
65Abnormality of alanine metabolism (HP:0010916)2.27351499
66Hyperalaninemia (HP:0003348)2.27351499
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27351499
68Conjugated hyperbilirubinemia (HP:0002908)2.25268535
69Abnormality of T cells (HP:0002843)2.24945099
70Tubular atrophy (HP:0000092)2.24620944
71Febrile seizures (HP:0002373)2.24452142
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.24022080
73Abnormality of secondary sexual hair (HP:0009888)2.22554579
74Abnormality of the axillary hair (HP:0100134)2.22554579
75Progressive inability to walk (HP:0002505)2.20761101
76Mitral stenosis (HP:0001718)2.20323486
77Congenital, generalized hypertrichosis (HP:0004540)2.19876074
78Deep venous thrombosis (HP:0002625)2.19719396
79Absent speech (HP:0001344)2.16907171
80Urinary glycosaminoglycan excretion (HP:0003541)2.16466055
81Mucopolysacchariduria (HP:0008155)2.16466055
82Recurrent gram-negative bacterial infections (HP:0005420)2.15605783
83Keratoconjunctivitis (HP:0001096)2.15049014
84Recurrent fungal infections (HP:0002841)2.14860512
85Increased cerebral lipofuscin (HP:0011813)2.13944189
86Abnormal drinking behavior (HP:0030082)2.12949352
87Polydipsia (HP:0001959)2.12949352
88Tetraplegia (HP:0002445)2.10380452
89Chronic hepatic failure (HP:0100626)2.09765967
90Increased CSF protein (HP:0002922)2.09218844
91Xanthomatosis (HP:0000991)2.08471270
92Retinal atrophy (HP:0001105)2.08350682
93Gangrene (HP:0100758)2.08183577
94IgA deficiency (HP:0002720)2.07547798
95Skin nodule (HP:0200036)2.07347817
96Abnormality of renin-angiotensin system (HP:0000847)2.07199878
97Renal cortical cysts (HP:0000803)2.05904477
98Menorrhagia (HP:0000132)2.05587181
99Abnormal rod and cone electroretinograms (HP:0008323)2.05011777
100Abnormal ciliary motility (HP:0012262)2.04991970
101Lip pit (HP:0100267)2.03866215
102Prostate neoplasm (HP:0100787)2.03560817
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03160248
104Abnormality of polysaccharide metabolism (HP:0011012)2.03160248
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03160248
106Prolonged bleeding time (HP:0003010)2.01517564
107Decreased central vision (HP:0007663)2.01021602
108Protruding tongue (HP:0010808)2.00499093
109Recurrent bronchitis (HP:0002837)1.98296017
110Elevated erythrocyte sedimentation rate (HP:0003565)1.98105495
111Macroorchidism (HP:0000053)1.98099065
112Short hallux (HP:0010109)1.94318054
113Hemoptysis (HP:0002105)1.93505326
114Abnormal respiratory epithelium morphology (HP:0012253)1.92803060
115Abnormal respiratory motile cilium morphology (HP:0005938)1.92803060
116Gingival bleeding (HP:0000225)1.92090260
117Anorexia (HP:0002039)1.91825408
118Widely spaced teeth (HP:0000687)1.91678860
119Cystic liver disease (HP:0006706)1.91047617
120Hypochromic microcytic anemia (HP:0004840)1.90328516
121Pulmonary embolism (HP:0002204)1.89763509
122Abnormality of ocular smooth pursuit (HP:0000617)1.89410374
123Hypothermia (HP:0002045)1.89262742
124Medial flaring of the eyebrow (HP:0010747)1.87548659
125Type II lissencephaly (HP:0007260)1.87165400
126Broad-based gait (HP:0002136)1.85479056
127Metabolic alkalosis (HP:0200114)1.84848550
128Papilledema (HP:0001085)1.83448351
129Thyroiditis (HP:0100646)1.83033880
130Recurrent bacterial skin infections (HP:0005406)1.82236536
131Aplasia/Hypoplasia of the hallux (HP:0008362)1.81555222
132Erythroderma (HP:0001019)1.81521938
133Visual hallucinations (HP:0002367)1.81296664
134Focal seizures (HP:0007359)1.80900020
135Vasculitis (HP:0002633)1.80297894
136Generalized hypopigmentation of hair (HP:0011358)1.79824517
137Hypoplastic labia majora (HP:0000059)1.79572301
138Hypoalphalipoproteinemia (HP:0003233)1.78704331
139Disproportionate short-trunk short stature (HP:0003521)1.78207928
140Diplopia (HP:0000651)1.78133568
141Abnormality of binocular vision (HP:0011514)1.78133568
142Increased IgM level (HP:0003496)1.77834546
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.77598913
144Hypoplasia of the fovea (HP:0007750)1.77598913
145Complement deficiency (HP:0004431)1.77536718
146IgG deficiency (HP:0004315)1.77241001
147Keratoconjunctivitis sicca (HP:0001097)1.76769944
148Joint hemorrhage (HP:0005261)1.75870018
149Chronic otitis media (HP:0000389)1.75674112
150Epileptiform EEG discharges (HP:0011182)1.75472886
151EEG with generalized epileptiform discharges (HP:0011198)1.75464891
152Epidermoid cyst (HP:0200040)1.74573320
153Abnormality of calcium-phosphate metabolism (HP:0100530)1.74016682
154Recurrent viral infections (HP:0004429)1.73808848
155Dialeptic seizures (HP:0011146)1.73786985
156Hyperlipoproteinemia (HP:0010980)1.73467080
157Large for gestational age (HP:0001520)1.71831542
158Striae distensae (HP:0001065)1.71704168
159Aneurysm (HP:0002617)1.71296918
160Abnormality of T cell physiology (HP:0011840)1.69263833
161Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69165457
162Dysostosis multiplex (HP:0000943)1.68962866
163Vacuolated lymphocytes (HP:0001922)1.68830273
164Autoimmune thrombocytopenia (HP:0001973)1.68704494
165Blue irides (HP:0000635)1.68702899
166Chorioretinal atrophy (HP:0000533)1.68295943
167Periodontitis (HP:0000704)1.67832352
168Status epilepticus (HP:0002133)1.67694257
169Abnormality of the nasal septum (HP:0000419)1.66585451
170Asplenia (HP:0001746)1.66547935
171Palmoplantar hyperkeratosis (HP:0000972)1.66202350
172Scanning speech (HP:0002168)1.66019288
173Agitation (HP:0000713)1.65964531
174Truncal ataxia (HP:0002078)1.65613232
175Aplasia/Hypoplasia of the spleen (HP:0010451)1.65564625
176Vertebral arch anomaly (HP:0008438)1.64848469
177Resting tremor (HP:0002322)1.64617775
178Hypsarrhythmia (HP:0002521)1.63905449
179Glucose intolerance (HP:0000833)1.61445685
180Limb hypertonia (HP:0002509)1.61095886
181Type I diabetes mellitus (HP:0100651)1.60974572
182Coarse hair (HP:0002208)1.60078135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.04985213
2TXK3.86492659
3INSRR3.16727199
4TAOK33.07932794
5ADRBK23.00830937
6MAP3K142.80422336
7JAK12.76045821
8FGFR42.71629063
9BMPR1B2.63871349
10JAK32.44721837
11FRK2.35957130
12EPHA32.33855405
13MAP4K12.28658658
14FGFR32.21956190
15NTRK32.07802938
16MAP3K131.97329403
17ITK1.93405516
18TYK21.92133027
19GRK11.90843476
20TNIK1.90694973
21MAP3K21.87863497
22PRKCH1.69227161
23WNK31.62960592
24MST41.53764321
25CASK1.49448318
26OXSR11.44704894
27ZAP701.43933495
28CDK121.43819662
29JAK21.43231330
30RIPK41.42621642
31HIPK21.39866228
32STK391.39716087
33AKT31.38032986
34CAMKK21.35471798
35IKBKE1.29332865
36FGFR21.27994304
37PINK11.27023486
38NUAK11.25256761
39MAP3K91.24793716
40STK241.22804708
41IRAK31.22240566
42WNK41.20310018
43PTK2B1.18217262
44SIK21.17245080
45BMPR21.15417100
46TGFBR11.15044038
47CAMKK11.13400827
48PTK61.12867791
49MAP3K11.12269239
50PRKD31.09919426
51MAP3K71.08695291
52SIK11.08240838
53GRK71.06822925
54ADRBK11.04594640
55FER1.01093625
56SGK30.99249027
57MAPK130.98822484
58RIPK10.98533404
59CSK0.95617371
60MAP4K20.94010468
61LCK0.93659322
62BTK0.93408771
63CDC42BPA0.91345479
64ALK0.90667035
65PDGFRA0.89892482
66RET0.88614768
67STK30.88233391
68TRPM70.86132991
69PLK20.86007614
70KSR20.85932514
71SGK20.85230235
72MAP2K40.83529105
73HCK0.82562518
74MAP3K40.81705996
75PDK10.81342824
76SGK4940.80748828
77SGK2230.80748828
78CHUK0.80527614
79PRKCQ0.80482370
80WNK10.79806133
81PIK3CA0.79608732
82BLK0.79602952
83IRAK10.79562238
84PRKCE0.78271078
85PAK30.76928167
86FGR0.74341912
87ZAK0.74261389
88CDK60.74194189
89MARK30.73476449
90TBK10.73196888
91GRK60.72576328
92BMX0.72184823
93LYN0.71914720
94TLK10.70427658
95PIK3CG0.69566690
96CAMK1G0.69393386
97PRKAA20.69012627
98IKBKB0.68899484
99SYK0.66016950
100PDGFRB0.64913196
101TEC0.64903475
102STK380.64415805
103IRAK40.64130270
104PTK20.63998606
105NLK0.59988754
106PRKD20.58946271
107PRKCG0.58925017
108NEK90.58474734
109IGF1R0.58417761
110ERN10.58284736
111PAK60.58187825
112TNK20.57091400
113GRK50.56770617
114KIT0.55634445
115NTRK20.54501241
116MATK0.54455339
117ERBB20.54363673
118MELK0.53478458
119ERBB40.51513874
120STK38L0.50628846
121MAP3K50.50138818
122BRSK20.49690915
123MKNK20.49664275
124MAP2K60.48518595
125EPHA20.47329653
126MAPK150.46409852
127INSR0.46354927
128STK110.45436757
129SGK10.45393094
130CAMK1D0.44429103
131TRIB30.43610511
132CAMK2A0.42991923
133SIK30.42628136
134STK100.41416160
135DAPK20.41096321
136ABL10.40494533
137PIM10.40270978
138PDPK10.40049435
139MAP2K10.38609575
140ERBB30.37994374
141NTRK10.37277442
142BRD40.37215957
143FGFR10.36752184
144LATS10.36382436
145RPS6KA30.35379475
146EPHA40.33402583
147FES0.32744450
148EGFR0.32488573
149MST1R0.32054555
150MAPK70.31634846

Predicted pathways (KEGG)

RankGene SetZ-score
1Type I diabetes mellitus_Homo sapiens_hsa049403.08116097
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.81920140
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71158832
4Linoleic acid metabolism_Homo sapiens_hsa005912.53544202
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.18469354
6Allograft rejection_Homo sapiens_hsa053302.16342311
7Graft-versus-host disease_Homo sapiens_hsa053322.14579460
8Nitrogen metabolism_Homo sapiens_hsa009102.14451519
9Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92908378
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.87636653
11Ether lipid metabolism_Homo sapiens_hsa005651.85088334
12Phototransduction_Homo sapiens_hsa047441.76337135
13Insulin secretion_Homo sapiens_hsa049111.74293106
14Type II diabetes mellitus_Homo sapiens_hsa049301.69917274
15T cell receptor signaling pathway_Homo sapiens_hsa046601.63918938
16Autoimmune thyroid disease_Homo sapiens_hsa053201.48636433
17Arginine biosynthesis_Homo sapiens_hsa002201.42159560
18Arachidonic acid metabolism_Homo sapiens_hsa005901.36562017
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35172306
20Primary immunodeficiency_Homo sapiens_hsa053401.28861404
21Glycerolipid metabolism_Homo sapiens_hsa005611.27246469
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26880347
23Staphylococcus aureus infection_Homo sapiens_hsa051501.26194739
24Serotonergic synapse_Homo sapiens_hsa047261.25417771
25Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.23967353
26Butanoate metabolism_Homo sapiens_hsa006501.22807991
27Long-term potentiation_Homo sapiens_hsa047201.22328008
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21843781
29Chemical carcinogenesis_Homo sapiens_hsa052041.21807694
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.19864567
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.19077565
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.18929347
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.18915457
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.18647413
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.16966819
36Retinol metabolism_Homo sapiens_hsa008301.16113386
37Histidine metabolism_Homo sapiens_hsa003401.14778582
38Prolactin signaling pathway_Homo sapiens_hsa049171.14136173
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12633296
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11782993
41ABC transporters_Homo sapiens_hsa020101.08786900
42Mineral absorption_Homo sapiens_hsa049781.08687893
43Measles_Homo sapiens_hsa051621.08606689
44Platelet activation_Homo sapiens_hsa046111.06771449
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05696505
46Osteoclast differentiation_Homo sapiens_hsa043801.01314228
47Complement and coagulation cascades_Homo sapiens_hsa046101.01206443
48Fat digestion and absorption_Homo sapiens_hsa049751.00908077
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99888968
50GABAergic synapse_Homo sapiens_hsa047270.99575892
51TNF signaling pathway_Homo sapiens_hsa046680.99372505
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96879993
53mTOR signaling pathway_Homo sapiens_hsa041500.95969190
54Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95830431
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95606973
56Synaptic vesicle cycle_Homo sapiens_hsa047210.94054334
57Vitamin digestion and absorption_Homo sapiens_hsa049770.93305138
58Amphetamine addiction_Homo sapiens_hsa050310.93229194
59Ovarian steroidogenesis_Homo sapiens_hsa049130.92040198
60Inositol phosphate metabolism_Homo sapiens_hsa005620.91274566
61Sulfur metabolism_Homo sapiens_hsa009200.90778248
62Leishmaniasis_Homo sapiens_hsa051400.89923423
63Collecting duct acid secretion_Homo sapiens_hsa049660.89331969
64Insulin resistance_Homo sapiens_hsa049310.88999232
65Sphingolipid metabolism_Homo sapiens_hsa006000.88502409
66Dorso-ventral axis formation_Homo sapiens_hsa043200.87442427
67Bile secretion_Homo sapiens_hsa049760.86756185
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84851019
69Olfactory transduction_Homo sapiens_hsa047400.84217049
70Morphine addiction_Homo sapiens_hsa050320.83158551
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83029050
72Nicotine addiction_Homo sapiens_hsa050330.82608673
73Renin secretion_Homo sapiens_hsa049240.82410210
74Chemokine signaling pathway_Homo sapiens_hsa040620.81753357
75Long-term depression_Homo sapiens_hsa047300.81751380
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80154820
77Salivary secretion_Homo sapiens_hsa049700.78286037
78Circadian rhythm_Homo sapiens_hsa047100.78275334
79Rheumatoid arthritis_Homo sapiens_hsa053230.76539473
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75528949
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75303957
82Regulation of autophagy_Homo sapiens_hsa041400.75134939
83Prion diseases_Homo sapiens_hsa050200.74543156
84Circadian entrainment_Homo sapiens_hsa047130.73968355
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73963115
86Caffeine metabolism_Homo sapiens_hsa002320.72995434
87Calcium signaling pathway_Homo sapiens_hsa040200.72506436
88Glucagon signaling pathway_Homo sapiens_hsa049220.71604914
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.70612777
90Antigen processing and presentation_Homo sapiens_hsa046120.70372968
91Toxoplasmosis_Homo sapiens_hsa051450.68512567
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68167073
93Cholinergic synapse_Homo sapiens_hsa047250.67284359
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67028866
95Taste transduction_Homo sapiens_hsa047420.66905189
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.66570366
97Lysosome_Homo sapiens_hsa041420.64236018
98Glutamatergic synapse_Homo sapiens_hsa047240.64121033
99African trypanosomiasis_Homo sapiens_hsa051430.63794303
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63674382
101Selenocompound metabolism_Homo sapiens_hsa004500.63569067
102Estrogen signaling pathway_Homo sapiens_hsa049150.61983212
103Asthma_Homo sapiens_hsa053100.61865710
104Fatty acid biosynthesis_Homo sapiens_hsa000610.60923369
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.60908814
106Hematopoietic cell lineage_Homo sapiens_hsa046400.60488693
107Gastric acid secretion_Homo sapiens_hsa049710.60418625
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59309614
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58600784
110Cocaine addiction_Homo sapiens_hsa050300.58239135
111Dopaminergic synapse_Homo sapiens_hsa047280.58212640
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57761888
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57100586
114Pancreatic secretion_Homo sapiens_hsa049720.56690354
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55951616
116Tryptophan metabolism_Homo sapiens_hsa003800.55584575
117Tuberculosis_Homo sapiens_hsa051520.55525301
118Acute myeloid leukemia_Homo sapiens_hsa052210.55272362
119Oxytocin signaling pathway_Homo sapiens_hsa049210.55153248
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55040927
121cAMP signaling pathway_Homo sapiens_hsa040240.54273008
122Thyroid hormone synthesis_Homo sapiens_hsa049180.53621211
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53274733
124PPAR signaling pathway_Homo sapiens_hsa033200.52120483
125MAPK signaling pathway_Homo sapiens_hsa040100.52047302
126Peroxisome_Homo sapiens_hsa041460.52016645
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51554214
128Renin-angiotensin system_Homo sapiens_hsa046140.50965128
129Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.50534237
130Malaria_Homo sapiens_hsa051440.50221065
131GnRH signaling pathway_Homo sapiens_hsa049120.50213906
132Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49502767
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.49043767
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48929504
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47383304
136Starch and sucrose metabolism_Homo sapiens_hsa005000.46941115
137B cell receptor signaling pathway_Homo sapiens_hsa046620.46260646
138Amoebiasis_Homo sapiens_hsa051460.46116574
139Influenza A_Homo sapiens_hsa051640.45256759
140Glioma_Homo sapiens_hsa052140.45018226
141Legionellosis_Homo sapiens_hsa051340.44971154
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44749280

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