TTC39C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.47736008
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.47736008
3L-phenylalanine metabolic process (GO:0006558)7.10957772
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.10957772
5aromatic amino acid family catabolic process (GO:0009074)6.93987463
6tryptophan catabolic process (GO:0006569)6.52033002
7indole-containing compound catabolic process (GO:0042436)6.52033002
8indolalkylamine catabolic process (GO:0046218)6.52033002
9kynurenine metabolic process (GO:0070189)6.33041016
10bile acid biosynthetic process (GO:0006699)6.25897095
11tryptophan metabolic process (GO:0006568)6.08744493
12complement activation, alternative pathway (GO:0006957)5.87672569
13glyoxylate metabolic process (GO:0046487)5.81973601
14urea metabolic process (GO:0019627)5.81750621
15urea cycle (GO:0000050)5.81750621
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.78067632
17regulation of protein activation cascade (GO:2000257)5.71501226
18alpha-linolenic acid metabolic process (GO:0036109)5.54602684
19regulation of complement activation (GO:0030449)5.42941114
20negative regulation of fibrinolysis (GO:0051918)5.35852816
21nitrogen cycle metabolic process (GO:0071941)5.34068761
22protein carboxylation (GO:0018214)5.32713387
23peptidyl-glutamic acid carboxylation (GO:0017187)5.32713387
24regulation of fibrinolysis (GO:0051917)5.26006034
25cysteine metabolic process (GO:0006534)5.24362507
26sulfur amino acid catabolic process (GO:0000098)5.18868271
27water-soluble vitamin biosynthetic process (GO:0042364)5.18646049
28bile acid metabolic process (GO:0008206)5.13597410
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.13450104
30DNA deamination (GO:0045006)5.10778694
31high-density lipoprotein particle remodeling (GO:0034375)5.08569612
32aromatic amino acid family metabolic process (GO:0009072)4.99917659
33serine family amino acid catabolic process (GO:0009071)4.91958067
34homocysteine metabolic process (GO:0050667)4.84746154
35coenzyme catabolic process (GO:0009109)4.79923474
36regulation of triglyceride catabolic process (GO:0010896)4.70152888
37tyrosine metabolic process (GO:0006570)4.66789408
38indolalkylamine metabolic process (GO:0006586)4.59538898
39sulfation (GO:0051923)4.59316483
40alpha-amino acid catabolic process (GO:1901606)4.58440221
41lysine catabolic process (GO:0006554)4.58130567
42lysine metabolic process (GO:0006553)4.58130567
43cellular biogenic amine catabolic process (GO:0042402)4.51757288
44amine catabolic process (GO:0009310)4.51757288
45reverse cholesterol transport (GO:0043691)4.50162699
46protein-lipid complex remodeling (GO:0034368)4.45872200
47macromolecular complex remodeling (GO:0034367)4.45872200
48plasma lipoprotein particle remodeling (GO:0034369)4.45872200
49amino-acid betaine metabolic process (GO:0006577)4.45802193
50triglyceride homeostasis (GO:0070328)4.44751372
51acylglycerol homeostasis (GO:0055090)4.44751372
52regulation of cholesterol esterification (GO:0010872)4.37170020
53bile acid and bile salt transport (GO:0015721)4.34732942
54imidazole-containing compound metabolic process (GO:0052803)4.33403555
55cytolysis (GO:0019835)4.31453868
56glutamate metabolic process (GO:0006536)4.26983721
57phospholipid efflux (GO:0033700)4.25301694
58glycine metabolic process (GO:0006544)4.23548924
59cellular glucuronidation (GO:0052695)4.22195527
60cellular amino acid catabolic process (GO:0009063)4.20519894
61negative regulation of cholesterol transport (GO:0032375)4.17332178
62negative regulation of sterol transport (GO:0032372)4.17332178
63plasma lipoprotein particle clearance (GO:0034381)4.16588521
64ethanol oxidation (GO:0006069)4.15066358
65dicarboxylic acid biosynthetic process (GO:0043650)4.14542381
66behavioral response to nicotine (GO:0035095)4.12865609
67benzene-containing compound metabolic process (GO:0042537)4.12712674
68cellular modified amino acid catabolic process (GO:0042219)4.12158691
69cellular ketone body metabolic process (GO:0046950)4.09196289
70serine family amino acid metabolic process (GO:0009069)4.08261077
71fibrinolysis (GO:0042730)4.03101937
72complement activation, classical pathway (GO:0006958)4.01886138
73cholesterol efflux (GO:0033344)4.01227890
74cofactor catabolic process (GO:0051187)3.99886395
75arginine metabolic process (GO:0006525)3.96718906
76aldehyde catabolic process (GO:0046185)3.96418838
77complement activation (GO:0006956)3.92770667
78acetyl-CoA metabolic process (GO:0006084)3.89850421
79serine family amino acid biosynthetic process (GO:0009070)3.80871200
80regulation of bile acid biosynthetic process (GO:0070857)3.80622699
81protein activation cascade (GO:0072376)3.80444560
82uronic acid metabolic process (GO:0006063)3.78059047
83glucuronate metabolic process (GO:0019585)3.78059047
84low-density lipoprotein particle remodeling (GO:0034374)3.77008588
85phospholipid homeostasis (GO:0055091)3.76901391
86plasma lipoprotein particle assembly (GO:0034377)3.73961598
87regulation of cholesterol homeostasis (GO:2000188)3.71172721
88blood coagulation, intrinsic pathway (GO:0007597)3.69771893
89NAD biosynthetic process (GO:0009435)3.65841244
90cholesterol homeostasis (GO:0042632)3.64035701
91carboxylic acid catabolic process (GO:0046395)3.63460674
92organic acid catabolic process (GO:0016054)3.63460674
93positive regulation of lipid catabolic process (GO:0050996)3.63007070
94positive regulation of lipoprotein lipase activity (GO:0051006)3.60896334
95positive regulation of triglyceride lipase activity (GO:0061365)3.60896334
96nicotinamide nucleotide biosynthetic process (GO:0019359)3.59946241
97pyridine nucleotide biosynthetic process (GO:0019363)3.59946241
98sterol homeostasis (GO:0055092)3.58214046
99drug catabolic process (GO:0042737)3.57081429
100very-low-density lipoprotein particle assembly (GO:0034379)3.55900596
101ketone body metabolic process (GO:1902224)3.52655028
102exogenous drug catabolic process (GO:0042738)3.48167937
103urate metabolic process (GO:0046415)3.44994004
104plasma lipoprotein particle organization (GO:0071827)3.42231174
105opsonization (GO:0008228)3.41381316
106cellular response to ATP (GO:0071318)3.35853770
107cytidine metabolic process (GO:0046087)3.33704875
108cytidine catabolic process (GO:0006216)3.33704875
109cytidine deamination (GO:0009972)3.33704875
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21335026
111cell proliferation in forebrain (GO:0021846)3.12384634
112negative regulation of telomere maintenance (GO:0032205)3.08241386
113platelet dense granule organization (GO:0060155)3.07407564
114regulation of glomerulus development (GO:0090192)3.05035100
115flavonoid metabolic process (GO:0009812)3.02991256
116oxidative demethylation (GO:0070989)3.02179334
117L-fucose catabolic process (GO:0042355)2.99288103
118fucose catabolic process (GO:0019317)2.99288103
119L-fucose metabolic process (GO:0042354)2.99288103
120negative regulation of mast cell activation (GO:0033004)2.96247906
121purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.95169964
1223-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.95169964
123S-adenosylmethionine metabolic process (GO:0046500)2.93127034
124positive regulation of fatty acid beta-oxidation (GO:0032000)2.89034891
125regulation of DNA endoreduplication (GO:0032875)2.86758757
126somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.85533475
127isotype switching (GO:0045190)2.85533475
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.85533475
129positive regulation of mRNA catabolic process (GO:0061014)2.84717456
130pyrimidine ribonucleoside catabolic process (GO:0046133)2.84381951
131RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82798675
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.81370586
133positive regulation of fatty acid oxidation (GO:0046321)2.77312814
134positive regulation of defense response to virus by host (GO:0002230)2.76471166
135positive regulation of protein autophosphorylation (GO:0031954)2.74984077
136tolerance induction (GO:0002507)2.74053991
137protein polyglutamylation (GO:0018095)2.73102241
138indole-containing compound metabolic process (GO:0042430)2.73096588
139vitamin biosynthetic process (GO:0009110)2.69500839
140regulation of cell proliferation involved in kidney development (GO:1901722)2.68352781
141negative regulation of transcription regulatory region DNA binding (GO:2000678)2.66662879
142negative regulation of protein autophosphorylation (GO:0031953)2.65217462
143regulation of germinal center formation (GO:0002634)2.64960695
144regulation of T cell receptor signaling pathway (GO:0050856)2.64640232
145positive regulation of fatty acid transport (GO:2000193)2.64422093
146regulation of mitotic spindle checkpoint (GO:1903504)2.59761944
147regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59761944
148kidney morphogenesis (GO:0060993)2.59664749
149adaptation of signaling pathway (GO:0023058)2.59627999
150cellular response to interleukin-15 (GO:0071350)2.56568576
151regulation of glucokinase activity (GO:0033131)2.54302302
152regulation of hexokinase activity (GO:1903299)2.54302302
153regulation of regulatory T cell differentiation (GO:0045589)2.51566376
154limb bud formation (GO:0060174)2.48786675
155positive regulation of cAMP-mediated signaling (GO:0043950)2.48548546
156mitochondrial respiratory chain complex I assembly (GO:0032981)2.47650327
157NADH dehydrogenase complex assembly (GO:0010257)2.47650327
158mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.47650327
159negative T cell selection (GO:0043383)2.45181107
160DNA double-strand break processing (GO:0000729)2.43722843
161nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39242318
162gamma-aminobutyric acid transport (GO:0015812)2.38539540
163exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.38465836
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.38101307
165negative regulation of systemic arterial blood pressure (GO:0003085)2.37741168
166detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37405595
167detection of light stimulus involved in sensory perception (GO:0050962)2.36568492
168detection of light stimulus involved in visual perception (GO:0050908)2.36568492
169protein complex biogenesis (GO:0070271)2.36536482
170prostate gland growth (GO:0060736)2.36117151
171regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.36072529
172positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.36072529
173negative regulation by host of viral transcription (GO:0043922)2.35681280
174regulation of sequestering of triglyceride (GO:0010889)2.34912806
175GPI anchor metabolic process (GO:0006505)2.33892413
176positive regulation of icosanoid secretion (GO:0032305)2.33697556
177regulation of gene silencing by miRNA (GO:0060964)2.33268536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.09825700
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.94579527
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.90499679
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.33522946
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17573841
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.69623034
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.41590422
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00551911
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.65796522
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23537276
11ZNF274_21170338_ChIP-Seq_K562_Hela2.70695440
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.61347549
13VDR_22108803_ChIP-Seq_LS180_Human2.48830394
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46633580
15GBX2_23144817_ChIP-Seq_PC3_Human2.38949918
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32735152
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28646085
18* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.27688812
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21637884
20EWS_26573619_Chip-Seq_HEK293_Human2.11948784
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11029124
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05321145
23IGF1R_20145208_ChIP-Seq_DFB_Human2.01959478
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01012396
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.00620579
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5590088
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99764033
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.96584286
29P300_19829295_ChIP-Seq_ESCs_Human1.93187219
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91971826
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89595655
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88325289
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.86489412
34FUS_26573619_Chip-Seq_HEK293_Human1.84419697
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84147344
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.77848439
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.76328420
38IRF1_19129219_ChIP-ChIP_H3396_Human1.76016610
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.74807841
40ER_23166858_ChIP-Seq_MCF-7_Human1.73270496
41EZH2_27294783_Chip-Seq_NPCs_Mouse1.71377208
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68093458
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.66142352
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65539227
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64671510
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.60194750
47* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60147595
48KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.54923697
49HTT_18923047_ChIP-ChIP_STHdh_Human1.53101085
50RUNX_20019798_ChIP-Seq_JUKART_Human1.51854264
51GATA1_22025678_ChIP-Seq_K562_Human1.50968256
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49824846
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.49761471
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49492027
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48210615
56MYC_18940864_ChIP-ChIP_HL60_Human1.47795248
57IRF8_21731497_ChIP-ChIP_J774_Mouse1.47663027
58CBP_20019798_ChIP-Seq_JUKART_Human1.47490746
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47490746
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44483786
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43806331
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43139179
63CRX_20693478_ChIP-Seq_RETINA_Mouse1.42934738
64IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.42492040
65IRF8_22096565_ChIP-ChIP_GC-B_Human1.41919713
66CLOCK_20551151_ChIP-Seq_293T_Human1.40121779
67ELK1_19687146_ChIP-ChIP_HELA_Human1.40096216
68* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36239824
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34965629
70NANOG_19829295_ChIP-Seq_ESCs_Human1.31348293
71SOX2_19829295_ChIP-Seq_ESCs_Human1.31348293
72* STAT3_23295773_ChIP-Seq_U87_Human1.30459723
73VDR_23849224_ChIP-Seq_CD4+_Human1.30112146
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29875901
75GATA3_26560356_Chip-Seq_TH2_Human1.27166427
76TCF4_22108803_ChIP-Seq_LS180_Human1.26400280
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.25902171
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22795514
79FOXA1_25329375_ChIP-Seq_VCAP_Human1.22795514
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22544168
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22511884
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.22335292
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22126381
84P53_22387025_ChIP-Seq_ESCs_Mouse1.21931047
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.21610094
86* SMAD4_21799915_ChIP-Seq_A2780_Human1.19790759
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17561200
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16054961
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.16020142
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14885471
91* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14619294
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14572882
93TCF4_23295773_ChIP-Seq_U87_Human1.14385277
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.13535267
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12970158
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11571481
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11497803
98* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11442186
99AR_25329375_ChIP-Seq_VCAP_Human1.10910538
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.10230411
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10032673
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08500779
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08460973
104P300_18555785_Chip-Seq_ESCs_Mouse1.08184503
105TP53_22573176_ChIP-Seq_HFKS_Human1.08088780
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.07612800
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06934173
108SMAD3_21741376_ChIP-Seq_EPCs_Human1.05312484
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04576790
110E2F1_18555785_Chip-Seq_ESCs_Mouse1.02625881
111OCT4_18555785_Chip-Seq_ESCs_Mouse1.02419423
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02285245
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97353819
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91446122
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90746238
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85002177
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84195898
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82470373
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82386381
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80347061
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80347061
122* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78959421
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78816896
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76523173
125GATA4_25053715_ChIP-Seq_YYC3_Human0.75580415
126KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74279871
127ESR2_21235772_ChIP-Seq_MCF-7_Human0.72328690
128NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72250677
129ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.71489614
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70832124
131SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.70502478
132AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70279241
133ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69317051
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.69005755
135EGR1_19032775_ChIP-ChIP_M12_Human0.66871259
136ZNF263_19887448_ChIP-Seq_K562_Human0.66690586
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.66176141
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66139562
139TAF15_26573619_Chip-Seq_HEK293_Human0.62606830
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60897174
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.58758672
142CEBPB_22108803_ChIP-Seq_LS180_Human0.58203227
143RARB_24833708_ChIP-Seq_LIVER_Mouse0.57999782
144FOXA1_25552417_ChIP-Seq_VCAP_Human0.56320702
145MYC_19915707_ChIP-ChIP_AK7_Human0.55868163
146LXR_22292898_ChIP-Seq_THP-1_Human0.54747628
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.53874967
148NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.52596130
149FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52485914
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51867795
151IRF8_27001747_Chip-Seq_BMDM_Mouse0.51800038
152AR_20517297_ChIP-Seq_VCAP_Human0.51563738
153* STAT1_17558387_ChIP-Seq_HELA_Human0.49442715
154ESET_19884257_ChIP-Seq_ESCs_Mouse0.48965135
155CBP_21632823_ChIP-Seq_H3396_Human0.48769003
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.47291270
157CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.47044769
158* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.46752386
159P53_21459846_ChIP-Seq_SAOS-2_Human0.46659087
160* FOXO3_23340844_ChIP-Seq_DLD1_Human0.45657216
161* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.44782073
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.44720739
163STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44705870
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44359295
165ESR1_21235772_ChIP-Seq_MCF-7_Human0.44283141
166NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.44257067
167MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.44106815
168FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44010458
169BCAT_22108803_ChIP-Seq_LS180_Human0.43627771
170ESR1_20079471_ChIP-ChIP_T-47D_Human0.43620719
171TAF2_19829295_ChIP-Seq_ESCs_Human0.42959469
172PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42618431
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.42493718
174PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42309763
175GATA2_19941826_ChIP-Seq_K562_Human0.42115692
176SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40955714
177PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.40881306
178SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40333941
179ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.39747049
180CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.39441776
181SOX2_20726797_ChIP-Seq_SW620_Human0.39329148
182STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39107716
183MYC_27129775_Chip-Seq_CORNEA_Mouse0.38549058
184AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.37950821
185GATA1_19941826_ChIP-Seq_K562_Human0.37455310
186FOXH1_21741376_ChIP-Seq_EPCs_Human0.37085126
187CDX2_22108803_ChIP-Seq_LS180_Human0.36886377

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10557008
2MP0005360_urolithiasis7.58381639
3MP0005085_abnormal_gallbladder_physiolo6.43377552
4MP0005365_abnormal_bile_salt6.06531196
5MP0008875_abnormal_xenobiotic_pharmacok4.80789768
6MP0003806_abnormal_nucleotide_metabolis4.08614286
7MP0003252_abnormal_bile_duct4.03751116
8MP0010329_abnormal_lipoprotein_level3.47178309
9MP0005083_abnormal_biliary_tract3.20484391
10MP0009840_abnormal_foam_cell3.06982243
11MP0008877_abnormal_DNA_methylation2.84490401
12MP0003195_calcinosis2.80169599
13MP0005332_abnormal_amino_acid2.71796267
14MP0001666_abnormal_nutrient_absorption2.59062853
15MP0002102_abnormal_ear_morphology2.57598248
16MP0005671_abnormal_response_to2.54055476
17MP0003191_abnormal_cellular_cholesterol2.34956889
18MP0000609_abnormal_liver_physiology2.15816118
19MP0002163_abnormal_gland_morphology2.13885677
20MP0002138_abnormal_hepatobiliary_system2.08909418
21MP0004019_abnormal_vitamin_homeostasis2.08377597
22MP0002118_abnormal_lipid_homeostasis2.08025533
23MP0004134_abnormal_chest_morphology2.03007912
24MP0002160_abnormal_reproductive_system1.92412540
25MP0003868_abnormal_feces_composition1.91552755
26MP0005319_abnormal_enzyme/_coenzyme1.82914773
27MP0005389_reproductive_system_phenotype1.79065632
28MP0001485_abnormal_pinna_reflex1.75016944
29MP0005551_abnormal_eye_electrophysiolog1.73427511
30MP0006292_abnormal_olfactory_placode1.69035941
31MP0005379_endocrine/exocrine_gland_phen1.67680268
32MP0001764_abnormal_homeostasis1.62980385
33MP0003787_abnormal_imprinting1.62327122
34MP0006072_abnormal_retinal_apoptosis1.60612837
35MP0003763_abnormal_thymus_physiology1.59174424
36MP0002837_dystrophic_cardiac_calcinosis1.57795078
37MP0005646_abnormal_pituitary_gland1.57369470
38MP0005584_abnormal_enzyme/coenzyme_acti1.55157777
39MP0003646_muscle_fatigue1.54282038
40MP0004142_abnormal_muscle_tone1.44375927
41MP0009697_abnormal_copulation1.40012925
42MP0001873_stomach_inflammation1.38856162
43MP0003011_delayed_dark_adaptation1.38326145
44MP0001800_abnormal_humoral_immune1.36166939
45MP0002148_abnormal_hypersensitivity_rea1.32811689
46MP0004145_abnormal_muscle_electrophysio1.31051098
47MP0000685_abnormal_immune_system1.30257347
48MP0002166_altered_tumor_susceptibility1.30255067
49MP0005451_abnormal_body_composition1.29349907
50MP0001835_abnormal_antigen_presentation1.29180761
51MP0004885_abnormal_endolymph1.28641553
52MP0005647_abnormal_sex_gland1.27418241
53MP0001919_abnormal_reproductive_system1.23355556
54MP0009764_decreased_sensitivity_to1.22176803
55MP0003656_abnormal_erythrocyte_physiolo1.20888662
56MP0003186_abnormal_redox_activity1.20048403
57MP0003705_abnormal_hypodermis_morpholog1.19590404
58MP0009643_abnormal_urine_homeostasis1.18668839
59MP0000598_abnormal_liver_morphology1.16617294
60MP0005075_abnormal_melanosome_morpholog1.16437093
61MP0000372_irregular_coat_pigmentation1.16325007
62MP0001968_abnormal_touch/_nociception1.16249039
63MP0000604_amyloidosis1.15578078
64MP0002254_reproductive_system_inflammat1.12952673
65MP0005253_abnormal_eye_physiology1.09193584
66MP0009763_increased_sensitivity_to1.08231783
67MP0002277_abnormal_respiratory_mucosa1.06897404
68MP0003786_premature_aging1.04488108
69MP0002723_abnormal_immune_serum1.02761454
70MP0001986_abnormal_taste_sensitivity1.01521312
71MP0008469_abnormal_protein_level1.01389593
72MP0004133_heterotaxia1.00934768
73MP0005000_abnormal_immune_tolerance1.00927796
74MP0002282_abnormal_trachea_morphology0.98772062
75MP0000689_abnormal_spleen_morphology0.97034231
76MP0009250_abnormal_appendicular_skeleto0.96191395
77MP0000049_abnormal_middle_ear0.95426678
78MP0000631_abnormal_neuroendocrine_gland0.94605239
79MP0008058_abnormal_DNA_repair0.94463467
80MP0000613_abnormal_salivary_gland0.94352388
81MP0005387_immune_system_phenotype0.93343112
82MP0001790_abnormal_immune_system0.93343112
83MP0002751_abnormal_autonomic_nervous0.92964014
84MP0002272_abnormal_nervous_system0.92044450
85MP0000569_abnormal_digit_pigmentation0.91568817
86MP0005636_abnormal_mineral_homeostasis0.90522021
87MP0005084_abnormal_gallbladder_morpholo0.90083684
88MP0010386_abnormal_urinary_bladder0.88909591
89MP0002420_abnormal_adaptive_immunity0.88285286
90MP0009745_abnormal_behavioral_response0.87767902
91MP0001819_abnormal_immune_cell0.86858077
92MP0002736_abnormal_nociception_after0.86185206
93MP0009642_abnormal_blood_homeostasis0.86127324
94MP0002452_abnormal_antigen_presenting0.85756189
95MP0002006_tumorigenesis0.85141623
96MP0003866_abnormal_defecation0.84353388
97MP0005174_abnormal_tail_pigmentation0.83421765
98MP0001119_abnormal_female_reproductive0.82936399
99MP0009765_abnormal_xenobiotic_induced0.81970686
100MP0010368_abnormal_lymphatic_system0.80841674
101MP0002876_abnormal_thyroid_physiology0.80732152
102MP0003283_abnormal_digestive_organ0.80401460
103MP0000703_abnormal_thymus_morphology0.78267512
104MP0003690_abnormal_glial_cell0.77652678
105MP0005408_hypopigmentation0.77593606
106MP0005535_abnormal_body_temperature0.77574022
107MP0001984_abnormal_olfaction0.77135867
108MP0005376_homeostasis/metabolism_phenot0.76867614
109MP0002638_abnormal_pupillary_reflex0.76473487
110MP0005310_abnormal_salivary_gland0.74915680
111MP0003436_decreased_susceptibility_to0.74479110
112MP0008995_early_reproductive_senescence0.74337128
113MP0002078_abnormal_glucose_homeostasis0.74206193
114MP0004130_abnormal_muscle_cell0.73265749
115MP0003329_amyloid_beta_deposits0.72984151
116MP0005220_abnormal_exocrine_pancreas0.72090315
117MP0005670_abnormal_white_adipose0.72023140
118MP0002971_abnormal_brown_adipose0.71930358
119MP0003724_increased_susceptibility_to0.71684018
120MP0002938_white_spotting0.70990792
121MP0009333_abnormal_splenocyte_physiolog0.70413862
122MP0005334_abnormal_fat_pad0.69959390
123MP0004381_abnormal_hair_follicle0.68475688
124MP0001177_atelectasis0.67447722
125MP0004742_abnormal_vestibular_system0.67438059
126MP0000716_abnormal_immune_system0.66573936
127MP0006036_abnormal_mitochondrial_physio0.66104214
128MP0002928_abnormal_bile_duct0.62149965
129MP0005266_abnormal_metabolism0.62109786
130MP0005464_abnormal_platelet_physiology0.61526723
131MP0006082_CNS_inflammation0.61424670
132MP0005166_decreased_susceptibility_to0.57368334
133MP0001661_extended_life_span0.56551429
134MP0000579_abnormal_nail_morphology0.54710521
135MP0003075_altered_response_to0.54216792
136MP0005448_abnormal_energy_balance0.53953661
137MP0001756_abnormal_urination0.53467262
138MP0000639_abnormal_adrenal_gland0.53314774
139MP0009384_cardiac_valve_regurgitation0.51789441
140MP0006035_abnormal_mitochondrial_morpho0.50353179
141MP0008874_decreased_physiological_sensi0.47972790
142MP0005395_other_phenotype0.47042556
143MP0002136_abnormal_kidney_physiology0.46254896
144MP0009053_abnormal_anal_canal0.45275548
145MP0005058_abnormal_lysosome_morphology0.44949322
146MP0001853_heart_inflammation0.44625461
147MP0008873_increased_physiological_sensi0.44068211
148MP0003638_abnormal_response/metabolism_0.43642117
149MP0002822_catalepsy0.43281345
150MP0009785_altered_susceptibility_to0.41101928
151MP0009379_abnormal_foot_pigmentation0.40973476
152MP0001845_abnormal_inflammatory_respons0.40722904
153MP0002796_impaired_skin_barrier0.40208997
154MP0004782_abnormal_surfactant_physiolog0.39544446
155MP0003953_abnormal_hormone_level0.37158410
156MP0002168_other_aberrant_phenotype0.37054114
157MP0003718_maternal_effect0.37033707
158MP0001881_abnormal_mammary_gland0.36418040
159MP0004947_skin_inflammation0.35635448
160MP0010234_abnormal_vibrissa_follicle0.34343331
161MP0005666_abnormal_adipose_tissue0.33785748
162MP0009115_abnormal_fat_cell0.33328034
163MP0000427_abnormal_hair_cycle0.33029955
164MP0003453_abnormal_keratinocyte_physiol0.31727032
165MP0008872_abnormal_physiological_respon0.31344302
166MP0002419_abnormal_innate_immunity0.30448925
167MP0000249_abnormal_blood_vessel0.30429677
168MP0005248_abnormal_Harderian_gland0.29709314
169MP0005025_abnormal_response_to0.29608674
170MP0000230_abnormal_systemic_arterial0.29185730

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.50157374
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.18886668
3Deep venous thrombosis (HP:0002625)7.18277453
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58247089
5Prolonged partial thromboplastin time (HP:0003645)6.55097179
6Complement deficiency (HP:0004431)6.24676978
7Xanthomatosis (HP:0000991)6.24395957
8Hypobetalipoproteinemia (HP:0003563)6.12185861
9Hyperlipoproteinemia (HP:0010980)5.20354385
10Joint hemorrhage (HP:0005261)4.79356758
11Epidermoid cyst (HP:0200040)4.68500669
12Abnormality of complement system (HP:0005339)4.59702532
13Hypolipoproteinemia (HP:0010981)4.55839648
14Abnormality of the common coagulation pathway (HP:0010990)4.45189088
15Hyperammonemia (HP:0001987)4.38360839
16Hyperglycinemia (HP:0002154)4.32647603
17Fat malabsorption (HP:0002630)4.30227925
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.23099226
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.16650934
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.14793765
21Ketosis (HP:0001946)4.10650178
22Abnormality of methionine metabolism (HP:0010901)4.05274224
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.98361948
24Hypoalphalipoproteinemia (HP:0003233)3.97124437
25Pancreatic cysts (HP:0001737)3.81026332
26Conjugated hyperbilirubinemia (HP:0002908)3.75501053
27Abnormality of serine family amino acid metabolism (HP:0010894)3.75483479
28Abnormality of glycine metabolism (HP:0010895)3.75483479
29Abnormality of pyrimidine metabolism (HP:0004353)3.73446227
30Hyperglycinuria (HP:0003108)3.73024061
31Abnormality of the intrinsic pathway (HP:0010989)3.71020343
32Thyroiditis (HP:0100646)3.61935633
33Hypoglycemic coma (HP:0001325)3.53650369
34Hypercholesterolemia (HP:0003124)3.50461833
35Methylmalonic acidemia (HP:0002912)3.46145934
36Pendular nystagmus (HP:0012043)3.44063780
37Pancreatic fibrosis (HP:0100732)3.35049599
38Recurrent gram-negative bacterial infections (HP:0005420)3.34301575
39Systemic lupus erythematosus (HP:0002725)3.31033558
40Steatorrhea (HP:0002570)3.30348480
41Abolished electroretinogram (ERG) (HP:0000550)3.30009291
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27089096
43Myocardial infarction (HP:0001658)3.22856303
44True hermaphroditism (HP:0010459)3.19927625
45Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17768295
46Abnormality of fatty-acid metabolism (HP:0004359)3.15336104
47Hyperbilirubinemia (HP:0002904)3.15195100
48IgG deficiency (HP:0004315)3.06593045
49Spontaneous abortion (HP:0005268)3.02698702
50Abnormality of nucleobase metabolism (HP:0010932)3.01574142
51Abnormality of serum amino acid levels (HP:0003112)2.95262330
52Hepatocellular carcinoma (HP:0001402)2.93643418
53Skin nodule (HP:0200036)2.91582498
54Delayed CNS myelination (HP:0002188)2.89844036
55Hypochromic microcytic anemia (HP:0004840)2.85334600
56Abnormality of the renal cortex (HP:0011035)2.82323541
57Asplenia (HP:0001746)2.78539953
58Ketoacidosis (HP:0001993)2.77143948
59Genetic anticipation (HP:0003743)2.74176685
60Methylmalonic aciduria (HP:0012120)2.70337062
61Abnormal rod and cone electroretinograms (HP:0008323)2.66733127
62Abnormality of purine metabolism (HP:0004352)2.65638100
63Molar tooth sign on MRI (HP:0002419)2.65015813
64Abnormality of midbrain morphology (HP:0002418)2.65015813
65Nephronophthisis (HP:0000090)2.64118666
66Severe combined immunodeficiency (HP:0004430)2.63596116
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.61971833
68Conjunctival hamartoma (HP:0100780)2.61515913
69Decreased central vision (HP:0007663)2.57899133
70Acanthocytosis (HP:0001927)2.56697303
71Metabolic acidosis (HP:0001942)2.55562394
72Congenital stationary night blindness (HP:0007642)2.55205780
73Increased corneal curvature (HP:0100692)2.53182110
74Keratoconus (HP:0000563)2.53182110
75Mitral stenosis (HP:0001718)2.52056084
76Vascular calcification (HP:0004934)2.50740687
77Abnormality of the phalanges of the 2nd finger (HP:0009541)2.48211630
78Gout (HP:0001997)2.47927885
79Neonatal onset (HP:0003623)2.47002126
80Abnormal gallbladder morphology (HP:0012437)2.44610670
81Spastic diplegia (HP:0001264)2.42503285
82Abnormal gallbladder physiology (HP:0012438)2.41880666
83Cholecystitis (HP:0001082)2.41880666
84Hamartoma of the eye (HP:0010568)2.41801739
85Lethargy (HP:0001254)2.39515515
86Cholelithiasis (HP:0001081)2.38922214
87Glomerulonephritis (HP:0000099)2.36192501
88Sensorimotor neuropathy (HP:0007141)2.33711356
89Amyloidosis (HP:0011034)2.33369814
90Abnormality of T cell number (HP:0011839)2.33307091
91Irritability (HP:0000737)2.32066686
92Gingival bleeding (HP:0000225)2.30933253
93Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28996517
94Dicarboxylic aciduria (HP:0003215)2.28996517
95Hypoglycemic seizures (HP:0002173)2.28895087
96Furrowed tongue (HP:0000221)2.28547802
97Absent thumb (HP:0009777)2.27792460
98Abnormality of the renal medulla (HP:0100957)2.27359322
99Abnormality of DNA repair (HP:0003254)2.25592150
100Stomatitis (HP:0010280)2.24513109
101Gaze-evoked nystagmus (HP:0000640)2.22608509
102Progressive cerebellar ataxia (HP:0002073)2.22492559
103Cardiovascular calcification (HP:0011915)2.21904193
1043-Methylglutaconic aciduria (HP:0003535)2.21296108
105Cerebral edema (HP:0002181)2.21022682
106Abnormality of eosinophils (HP:0001879)2.20430232
107Congenital sensorineural hearing impairment (HP:0008527)2.19735769
108Hemorrhage of the eye (HP:0011885)2.18407753
109T lymphocytopenia (HP:0005403)2.16720630
110Pancreatitis (HP:0001733)2.16619569
111Esophageal varix (HP:0002040)2.16612740
112Malnutrition (HP:0004395)2.14454581
113Agitation (HP:0000713)2.13073862
114Thrombophlebitis (HP:0004418)2.12767900
115Menorrhagia (HP:0000132)2.11928597
116Chronic hepatic failure (HP:0100626)2.10333636
117Azoospermia (HP:0000027)2.09935286
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.08679224
119Prostate neoplasm (HP:0100787)2.08504223
120Brushfield spots (HP:0001088)2.07294273
121Abnormality of B cell number (HP:0010975)2.06212923
122Neoplasm of the adrenal cortex (HP:0100641)2.06176009
123Abnormality of homocysteine metabolism (HP:0010919)2.03453515
124Homocystinuria (HP:0002156)2.03453515
125Hypoproteinemia (HP:0003075)2.03409864
126Enlarged kidneys (HP:0000105)2.03294095
127Abnormality of the gallbladder (HP:0005264)2.02802935
128Cystic liver disease (HP:0006706)2.02593599
129Severe visual impairment (HP:0001141)2.01180301
130Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.00561108
131Short 1st metacarpal (HP:0010034)2.00561108
132Congenital, generalized hypertrichosis (HP:0004540)2.00328906
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.96336888
134Late onset (HP:0003584)1.96162832
135Porencephaly (HP:0002132)1.96092793
136Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95545667
137Attenuation of retinal blood vessels (HP:0007843)1.95534651
138Bile duct proliferation (HP:0001408)1.95056893
139Abnormal biliary tract physiology (HP:0012439)1.95056893
140Abnormal spermatogenesis (HP:0008669)1.95054601
141Abnormality of the labia minora (HP:0012880)1.94940716
142Aplasia/Hypoplasia of the uvula (HP:0010293)1.94361075
143Abnormal enzyme/coenzyme activity (HP:0012379)1.93833543
144Rickets (HP:0002748)1.93655113
145Combined immunodeficiency (HP:0005387)1.93362784
146Opisthotonus (HP:0002179)1.92662873
147Abnormality of iron homeostasis (HP:0011031)1.92338923
148Vomiting (HP:0002013)1.92226786
149Abnormality of the renal collecting system (HP:0004742)1.91853543
150Abnormality of the proximal phalanges of the hand (HP:0009834)1.91343381
151Abnormality of proline metabolism (HP:0010907)1.91157288
152Hydroxyprolinuria (HP:0003080)1.91157288
153Abnormality of chromosome stability (HP:0003220)1.90774961
154Sclerocornea (HP:0000647)1.88978107
155Mesomelia (HP:0003027)1.88936404
156Abnormality of the prostate (HP:0008775)1.88910608
157Carpal bone hypoplasia (HP:0001498)1.88719553
158Abnormality of transition element cation homeostasis (HP:0011030)1.88255987
159Male pseudohermaphroditism (HP:0000037)1.87435616
160Abnormality of the phalanges of the 5th finger (HP:0004213)1.86989772
161Poikilocytosis (HP:0004447)1.86989576
162Meckel diverticulum (HP:0002245)1.86587327
163Abnormality of the axillary hair (HP:0100134)1.85901777
164Abnormality of secondary sexual hair (HP:0009888)1.85901777
165Status epilepticus (HP:0002133)1.85602648
166B lymphocytopenia (HP:0010976)1.85147426
167Abnormality of the ileum (HP:0001549)1.85051375
168Generalized aminoaciduria (HP:0002909)1.84791601
169Eosinophilia (HP:0001880)1.84437464
170Hypophosphatemic rickets (HP:0004912)1.84165745
171Progressive inability to walk (HP:0002505)1.84071968
172Abnormality of vitamin B metabolism (HP:0004340)1.83706311
173Aplasia/Hypoplasia of the tongue (HP:0010295)1.83234961
174Autoimmune hemolytic anemia (HP:0001890)1.82820039
175Goiter (HP:0000853)1.82795822
176Elevated hepatic transaminases (HP:0002910)1.82517773
177Abnormal cartilage morphology (HP:0002763)1.80877544
178Stomach cancer (HP:0012126)1.80332920
179Meningioma (HP:0002858)1.78603125
180Hyperinsulinemic hypoglycemia (HP:0000825)1.78015445
181Hypothermia (HP:0002045)1.77494207
182Confusion (HP:0001289)1.77163502
183Elevated alkaline phosphatase (HP:0003155)1.76512470
184Nephritis (HP:0000123)1.75664066
185Abnormality of the nasal septum (HP:0000419)1.75142999
186Alkalosis (HP:0001948)1.75060633
187Renal cortical cysts (HP:0000803)1.73722694
188Pulmonary embolism (HP:0002204)1.73660941
189Chorioretinal atrophy (HP:0000533)1.73041616
190Abnormality of the 1st metacarpal (HP:0010009)1.71859185
191Aplasia/Hypoplasia of the tibia (HP:0005772)1.71159959

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.90447119
2ERN14.56331508
3FGFR44.55825354
4SIK14.04356194
5ERBB43.93678449
6NUAK13.50138320
7TAOK33.39405314
8TXK3.18257718
9ADRBK22.63441712
10INSRR2.59081136
11MAP4K22.52711570
12BMPR1B2.52148616
13ZAK2.47747782
14MAP2K42.32936402
15EIF2AK32.32000623
16ACVR1B2.21903471
17MAPK112.17061993
18TYK22.13186800
19TLK12.09094640
20MST1R2.02931447
21MST41.94506519
22MAP3K141.81539368
23VRK21.70342843
24VRK11.69758243
25TBK11.68380106
26NEK11.67277723
27WNK31.63788198
28NEK91.63215854
29ABL21.59865249
30LATS11.56644171
31JAK11.56054351
32DAPK21.53634717
33PKN21.50916039
34JAK21.48783353
35TNIK1.48782439
36PIK3CG1.43828066
37TRIM281.42823490
38FLT31.40614695
39TAF11.39820607
40PTK61.39357169
41TRIB31.38877926
42NLK1.34932365
43PLK31.31255047
44BUB11.25557487
45ERBB21.22144346
46MKNK21.22105101
47FGFR21.21785732
48STK161.18721143
49TEC1.18363105
50EPHB11.18355585
51MAP3K71.17674207
52FRK1.14402266
53IKBKE1.14347926
54OXSR11.10271974
55PINK11.04937441
56PLK21.02464401
57MAP3K131.02141949
58MAPK131.01311321
59PRKAA20.98994755
60GRK70.98890939
61KDR0.96390209
62CAMKK20.95285116
63ITK0.93652829
64IRAK30.93641088
65GRK60.92359698
66EPHA30.90239928
67STK390.90152934
68PRKCZ0.89881320
69EIF2AK10.88918624
70EIF2AK20.88911472
71MAPK40.87102364
72PIK3CA0.86474006
73PKN10.85014328
74CSK0.79353333
75PBK0.79208396
76BRSK20.78940959
77WNK40.78891924
78GRK50.78381931
79CDK60.77261860
80FGFR30.76878673
81CAMK2G0.76171752
82ERBB30.75275929
83MAP2K30.74715534
84MAP3K100.74169257
85MET0.72382472
86PRKACG0.70180873
87DYRK20.68802964
88CASK0.68618053
89TSSK60.66967178
90CSNK1G30.66806168
91SGK30.66481109
92DYRK1B0.65521727
93PRKCQ0.64474784
94CSNK1G20.64222941
95PRKD20.63984635
96GSK3A0.63604810
97MAP3K110.61935682
98SYK0.61512941
99ADRBK10.61505428
100LCK0.61307576
101MAPK120.60990812
102RIPK10.60213389
103MAP3K30.60111619
104PRKCE0.60073611
105PIM10.59891227
106MARK30.59873721
107PRKCI0.59715130
108IRAK20.59405441
109STK38L0.59132890
110PDPK10.58982242
111PRKAA10.58946761
112RET0.58229967
113MUSK0.57744879
114IRAK10.57340928
115MAPK150.56413514
116TGFBR10.54804079
117MAP3K50.54433227
118MAPKAPK50.54313821
119MAP3K10.53701981
120CSF1R0.53473937
121JAK30.53220929
122PTK20.52706436
123MAPKAPK30.52353026
124PLK40.51697282
125CSNK1A1L0.51606319
126LYN0.51545900
127MAP2K60.50529875
128BMX0.50319779
129RPS6KA50.50207815
130AKT30.49455595
131CAMK1D0.49232746
132PASK0.48065940
133KSR20.47871830
134ICK0.47592992
135CDC70.47294154
136EGFR0.46548191
137SGK20.46486765
138EPHA40.46296486
139BCR0.45798524
140IGF1R0.43526042
141FES0.43363349
142IKBKB0.42454425
143MKNK10.41661995
144BTK0.40612871
145PTK2B0.40276198
146PDK10.39581030
147MAPK70.39100638
148CSNK1A10.38293114
149MAP3K120.37504882
150HCK0.36407165
151ABL10.36361707
152NME10.35892068
153SGK4940.35735180
154SGK2230.35735180
155MAP2K10.35687789
156MELK0.35266566
157MAP4K10.34991580
158CHUK0.34581889
159PRKCG0.34146875
160ZAP700.33680230
161PRKACA0.33392631
162ATR0.33141987
163LATS20.32518721
164MAP3K40.32375517
165PRKCH0.31973642
166PLK10.31376249
167CSNK1G10.31091354
168MAP3K60.30726976
169MAP3K20.30461822
170KIT0.29442005
171TAOK20.28766768
172GRK10.28082286
173CDK40.26801925
174PRKCA0.26636936
175PAK30.26444254

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.92115194
2Nitrogen metabolism_Homo sapiens_hsa009103.60324873
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.52503442
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18702343
5Arginine biosynthesis_Homo sapiens_hsa002203.14493716
6Complement and coagulation cascades_Homo sapiens_hsa046102.93456468
7Tryptophan metabolism_Homo sapiens_hsa003802.74542518
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58119889
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52662507
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.51784717
11Fatty acid degradation_Homo sapiens_hsa000712.44903209
12Primary immunodeficiency_Homo sapiens_hsa053402.43211137
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29671843
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16961455
15Peroxisome_Homo sapiens_hsa041462.15516437
16Butanoate metabolism_Homo sapiens_hsa006502.09316862
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.07682129
18Homologous recombination_Homo sapiens_hsa034402.00257641
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99456841
20Protein export_Homo sapiens_hsa030601.95496644
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.90719494
22Staphylococcus aureus infection_Homo sapiens_hsa051501.90133117
23PPAR signaling pathway_Homo sapiens_hsa033201.88919177
24Histidine metabolism_Homo sapiens_hsa003401.88515443
25Chemical carcinogenesis_Homo sapiens_hsa052041.81919569
26Propanoate metabolism_Homo sapiens_hsa006401.80911200
27Caffeine metabolism_Homo sapiens_hsa002321.80717228
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77234934
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76498366
30Fatty acid metabolism_Homo sapiens_hsa012121.73156529
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71038484
32Retinol metabolism_Homo sapiens_hsa008301.67660440
33Proteasome_Homo sapiens_hsa030501.66577107
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.65667381
35beta-Alanine metabolism_Homo sapiens_hsa004101.63842680
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57607038
37Selenocompound metabolism_Homo sapiens_hsa004501.57378696
38Phototransduction_Homo sapiens_hsa047441.56658026
39RNA polymerase_Homo sapiens_hsa030201.55371553
40Phenylalanine metabolism_Homo sapiens_hsa003601.54710025
41Bile secretion_Homo sapiens_hsa049761.50497445
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47158563
43Basal transcription factors_Homo sapiens_hsa030221.45967497
44Intestinal immune network for IgA production_Homo sapiens_hsa046721.45413350
45Tyrosine metabolism_Homo sapiens_hsa003501.45378823
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43077950
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42710343
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34458415
49RNA degradation_Homo sapiens_hsa030181.33705310
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32341483
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31305358
52Pyruvate metabolism_Homo sapiens_hsa006201.30971247
53Fanconi anemia pathway_Homo sapiens_hsa034601.29983563
54Sulfur metabolism_Homo sapiens_hsa009201.28719875
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28522688
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28271957
57Starch and sucrose metabolism_Homo sapiens_hsa005001.27707496
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.26982580
59ABC transporters_Homo sapiens_hsa020101.23502678
60Fatty acid elongation_Homo sapiens_hsa000621.23495680
61Steroid biosynthesis_Homo sapiens_hsa001001.21555090
62Folate biosynthesis_Homo sapiens_hsa007901.15956354
63Biosynthesis of amino acids_Homo sapiens_hsa012301.14021239
64Autoimmune thyroid disease_Homo sapiens_hsa053201.12078079
65Type I diabetes mellitus_Homo sapiens_hsa049401.11953985
66Vitamin B6 metabolism_Homo sapiens_hsa007501.10556960
67Fat digestion and absorption_Homo sapiens_hsa049751.10278149
68Arachidonic acid metabolism_Homo sapiens_hsa005901.09064944
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08650264
70Allograft rejection_Homo sapiens_hsa053301.08168705
71Carbon metabolism_Homo sapiens_hsa012001.06153874
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04924678
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.01291456
74Oxidative phosphorylation_Homo sapiens_hsa001900.98548786
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90817539
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88944886
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87999342
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.87762063
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86309794
80Sulfur relay system_Homo sapiens_hsa041220.85749461
81Arginine and proline metabolism_Homo sapiens_hsa003300.85713195
82Non-homologous end-joining_Homo sapiens_hsa034500.84988545
83Asthma_Homo sapiens_hsa053100.84898207
84Vitamin digestion and absorption_Homo sapiens_hsa049770.81850688
85Ether lipid metabolism_Homo sapiens_hsa005650.77470642
86Lysine degradation_Homo sapiens_hsa003100.75065874
87Nicotine addiction_Homo sapiens_hsa050330.70918406
88Parkinsons disease_Homo sapiens_hsa050120.69865224
89One carbon pool by folate_Homo sapiens_hsa006700.68063365
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67380725
91Prion diseases_Homo sapiens_hsa050200.66137473
92Glycerolipid metabolism_Homo sapiens_hsa005610.66100455
93Nucleotide excision repair_Homo sapiens_hsa034200.60977205
94Taste transduction_Homo sapiens_hsa047420.60616410
95Glutathione metabolism_Homo sapiens_hsa004800.59811378
96Hematopoietic cell lineage_Homo sapiens_hsa046400.59611900
97Fatty acid biosynthesis_Homo sapiens_hsa000610.59086748
98T cell receptor signaling pathway_Homo sapiens_hsa046600.55724527
99Pentose phosphate pathway_Homo sapiens_hsa000300.53398729
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50189582
101Antigen processing and presentation_Homo sapiens_hsa046120.48487009
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47302692
103Mismatch repair_Homo sapiens_hsa034300.46723188
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44782092
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.42934876
106Metabolic pathways_Homo sapiens_hsa011000.40812139
107Purine metabolism_Homo sapiens_hsa002300.40288708
108Measles_Homo sapiens_hsa051620.35275350
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.33824977
110Alzheimers disease_Homo sapiens_hsa050100.33797309
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33018596
112p53 signaling pathway_Homo sapiens_hsa041150.32535225
113Pyrimidine metabolism_Homo sapiens_hsa002400.31780911
114Serotonergic synapse_Homo sapiens_hsa047260.30184907
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.30082884
116Melanoma_Homo sapiens_hsa052180.29785062
117Morphine addiction_Homo sapiens_hsa050320.26420473
118Insulin resistance_Homo sapiens_hsa049310.26287046
119Olfactory transduction_Homo sapiens_hsa047400.24955232
120Fructose and mannose metabolism_Homo sapiens_hsa000510.20893976
121Galactose metabolism_Homo sapiens_hsa000520.20584873
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20378556
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.16802339
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15453060
125Linoleic acid metabolism_Homo sapiens_hsa005910.12237487
126Glucagon signaling pathway_Homo sapiens_hsa049220.11272864
127AMPK signaling pathway_Homo sapiens_hsa041520.00143221
128Bladder cancer_Homo sapiens_hsa05219-0.2101151
129Malaria_Homo sapiens_hsa05144-0.2060871
130Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2057026
131Renin-angiotensin system_Homo sapiens_hsa04614-0.2030538
132Graft-versus-host disease_Homo sapiens_hsa05332-0.1976007
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1786459
134Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1520930
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1516278
136Pertussis_Homo sapiens_hsa05133-0.1382965
137Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1306459
138Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1305914
139Regulation of autophagy_Homo sapiens_hsa04140-0.1225441
140Amoebiasis_Homo sapiens_hsa05146-0.1155184
141Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1073955
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0999927
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0959810
144Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0916803
145Insulin signaling pathway_Homo sapiens_hsa04910-0.0910705
146Hepatitis C_Homo sapiens_hsa05160-0.0896964
147Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0615762
148African trypanosomiasis_Homo sapiens_hsa05143-0.0268408

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