TTC3P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.29152855
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.57092366
3substrate-independent telencephalic tangential migration (GO:0021826)4.57092366
4nucleobase catabolic process (GO:0046113)4.34203946
5presynaptic membrane assembly (GO:0097105)4.30870382
6postsynaptic membrane organization (GO:0001941)4.01391284
7axonal fasciculation (GO:0007413)3.88481730
8presynaptic membrane organization (GO:0097090)3.88382795
9detection of calcium ion (GO:0005513)3.81071787
10neuron recognition (GO:0008038)3.78920006
11limb bud formation (GO:0060174)3.76626854
12neuron cell-cell adhesion (GO:0007158)3.71492564
13behavioral response to ethanol (GO:0048149)3.66354902
14vocalization behavior (GO:0071625)3.63985873
15cerebral cortex radially oriented cell migration (GO:0021799)3.63702394
16auditory behavior (GO:0031223)3.54817835
17neuronal action potential (GO:0019228)3.52368850
18gamma-aminobutyric acid transport (GO:0015812)3.40973682
19valine metabolic process (GO:0006573)3.37589021
20startle response (GO:0001964)3.35113550
21behavioral response to nicotine (GO:0035095)3.33115342
22transmission of nerve impulse (GO:0019226)3.32416520
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.31002127
24positive regulation of synapse assembly (GO:0051965)3.22539891
25central nervous system projection neuron axonogenesis (GO:0021952)3.22366373
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.18820659
27dendritic spine morphogenesis (GO:0060997)3.18065989
28cell proliferation in forebrain (GO:0021846)3.11895025
29positive regulation of dendritic spine morphogenesis (GO:0061003)3.11419591
30negative regulation of astrocyte differentiation (GO:0048712)3.09116710
31hindbrain development (GO:0030902)3.03776089
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.02436540
33retinal ganglion cell axon guidance (GO:0031290)2.99772829
34glycosphingolipid biosynthetic process (GO:0006688)2.97074332
35regulation of dendritic spine morphogenesis (GO:0061001)2.96095853
36regulation of female receptivity (GO:0045924)2.95998491
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94812123
38glutamate receptor signaling pathway (GO:0007215)2.94658466
39establishment of mitochondrion localization (GO:0051654)2.94423997
40mechanosensory behavior (GO:0007638)2.94399422
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.89037785
42somite development (GO:0061053)2.87045624
43negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83876770
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.82408272
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.82408272
46regulation of translation, ncRNA-mediated (GO:0045974)2.82408272
47synapse assembly (GO:0007416)2.81484553
48adult walking behavior (GO:0007628)2.77310566
49synaptic transmission, glutamatergic (GO:0035249)2.77039510
50spinal cord development (GO:0021510)2.73890623
51dendrite morphogenesis (GO:0048813)2.72745733
52neuron-neuron synaptic transmission (GO:0007270)2.70296216
53regulation of timing of cell differentiation (GO:0048505)2.70247881
54action potential (GO:0001508)2.69392615
55regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.67729101
56neuronal action potential propagation (GO:0019227)2.66739537
57neurotransmitter-gated ion channel clustering (GO:0072578)2.65704111
58response to auditory stimulus (GO:0010996)2.65179657
59membrane depolarization during action potential (GO:0086010)2.58252556
60cornea development in camera-type eye (GO:0061303)2.57669836
61cerebral cortex cell migration (GO:0021795)2.56356879
62regulation of synapse structural plasticity (GO:0051823)2.56269398
63regulation of synapse assembly (GO:0051963)2.55122857
64central nervous system neuron axonogenesis (GO:0021955)2.53882494
65cell migration in hindbrain (GO:0021535)2.53452881
66short-term memory (GO:0007614)2.53096209
67calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.52218859
68protein localization to synapse (GO:0035418)2.51663393
69olfactory bulb development (GO:0021772)2.51507911
70epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51095902
71phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.50092825
72regulation of nuclear cell cycle DNA replication (GO:0033262)2.49949941
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49738716
74appendage development (GO:0048736)2.48985365
75limb development (GO:0060173)2.48985365
76negative regulation of glial cell differentiation (GO:0045686)2.48538902
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.47415717
78mitochondrion transport along microtubule (GO:0047497)2.47415717
79regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.46835051
80neuromuscular synaptic transmission (GO:0007274)2.45581690
81G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45304374
82serotonin metabolic process (GO:0042428)2.44719355
83kidney morphogenesis (GO:0060993)2.44423131
84regulation of development, heterochronic (GO:0040034)2.43289645
85central nervous system myelination (GO:0022010)2.42666484
86axon ensheathment in central nervous system (GO:0032291)2.42666484
87cAMP-mediated signaling (GO:0019933)2.42094865
88regulation of respiratory system process (GO:0044065)2.41761058
89regulation of neurotransmitter uptake (GO:0051580)2.40198408
90synapse organization (GO:0050808)2.38922124
91tongue development (GO:0043586)2.37063642
92regulation of growth hormone secretion (GO:0060123)2.35857480
93adult behavior (GO:0030534)2.35612072
94regulation of feeding behavior (GO:0060259)2.34912978
95regulation of calcium ion-dependent exocytosis (GO:0017158)2.34565910
96neuron migration (GO:0001764)2.34464410
97positive regulation of potassium ion transmembrane transport (GO:1901381)2.34364971
98synaptic vesicle maturation (GO:0016188)2.34223890
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.33229643
100cochlea development (GO:0090102)2.32712491

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08338789
2GBX2_23144817_ChIP-Seq_PC3_Human3.20058056
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90681290
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52195928
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47955214
6ZNF274_21170338_ChIP-Seq_K562_Hela2.44288975
7TAF15_26573619_Chip-Seq_HEK293_Human2.40315840
8IGF1R_20145208_ChIP-Seq_DFB_Human2.37462717
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.36263167
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26265220
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.21133440
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19635908
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18863911
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15737086
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14584830
16FUS_26573619_Chip-Seq_HEK293_Human2.11170558
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05454442
18VDR_22108803_ChIP-Seq_LS180_Human2.03756588
19AR_21572438_ChIP-Seq_LNCaP_Human2.03179377
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.99786568
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99753354
22REST_21632747_ChIP-Seq_MESCs_Mouse1.97035805
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.95551350
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.95404474
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94294619
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92907270
27P300_19829295_ChIP-Seq_ESCs_Human1.92711687
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91868031
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91030251
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85841749
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81913772
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77466298
33EWS_26573619_Chip-Seq_HEK293_Human1.76649967
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.74174035
35SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65527278
36JARID2_20075857_ChIP-Seq_MESCs_Mouse1.65002563
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61080944
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60905030
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60905030
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60178219
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58828743
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58828743
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58220305
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57452273
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57049174
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54743072
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.53086262
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.52773994
49AR_25329375_ChIP-Seq_VCAP_Human1.50515191
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50350998
51RNF2_27304074_Chip-Seq_NSC_Mouse1.49393373
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48241409
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47173384
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.45160305
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42718391
56STAT3_23295773_ChIP-Seq_U87_Human1.41283503
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39400652
58TCF4_23295773_ChIP-Seq_U87_Human1.37260753
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36796779
60NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35855089
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35554050
62DROSHA_22980978_ChIP-Seq_HELA_Human1.35240110
63BCAT_22108803_ChIP-Seq_LS180_Human1.34559026
64ER_23166858_ChIP-Seq_MCF-7_Human1.34232695
65KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32919542
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30909437
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.28269508
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27875672
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.25248667
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23166450
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22826515
72RUNX2_22187159_ChIP-Seq_PCA_Human1.20853514
73CBP_20019798_ChIP-Seq_JUKART_Human1.20363006
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20363006
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19424638
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19295481
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18675328
78LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17217782
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15406102
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.14340202
81KDM2B_26808549_Chip-Seq_REH_Human1.14255830
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13702288
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.10886440
84TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10686361
85TP63_19390658_ChIP-ChIP_HaCaT_Human1.10017714
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09852874
87TCF4_22108803_ChIP-Seq_LS180_Human1.09184723
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.08215058
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06345717
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05806123
91TP53_18474530_ChIP-ChIP_U2OS_Human1.05189094
92AR_19668381_ChIP-Seq_PC3_Human1.04273213
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02745596
94FLI1_27457419_Chip-Seq_LIVER_Mouse1.01442094
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01323903
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01047718
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.99729780
98CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97748491
99TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.96665297
100TAL1_26923725_Chip-Seq_HPCs_Mouse0.95754643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.03315553
2MP0002822_catalepsy2.97868221
3MP0003787_abnormal_imprinting2.77717101
4MP0000778_abnormal_nervous_system2.63443630
5MP0006292_abnormal_olfactory_placode2.61237872
6MP0004859_abnormal_synaptic_plasticity2.50217685
7MP0003122_maternal_imprinting2.28311187
8MP0001529_abnormal_vocalization2.23148214
9MP0005646_abnormal_pituitary_gland2.16778006
10MP0003121_genomic_imprinting2.12995586
11MP0001486_abnormal_startle_reflex2.10230488
12MP0003635_abnormal_synaptic_transmissio2.08563490
13MP0004885_abnormal_endolymph2.03153377
14MP0003136_yellow_coat_color2.02391569
15MP0009745_abnormal_behavioral_response1.96267808
16MP0002272_abnormal_nervous_system1.95490319
17MP0009780_abnormal_chondrocyte_physiolo1.95302438
18MP0002102_abnormal_ear_morphology1.94564744
19MP0002064_seizures1.92267109
20MP0001188_hyperpigmentation1.90308035
21MP0004270_analgesia1.85378732
22MP0001968_abnormal_touch/_nociception1.85344109
23MP0009046_muscle_twitch1.85284229
24MP0002734_abnormal_mechanical_nocicepti1.80224030
25MP0002063_abnormal_learning/memory/cond1.78172480
26MP0000631_abnormal_neuroendocrine_gland1.69093661
27MP0002572_abnormal_emotion/affect_behav1.67261360
28MP0008877_abnormal_DNA_methylation1.66387196
29MP0006276_abnormal_autonomic_nervous1.65588759
30MP0002736_abnormal_nociception_after1.63839302
31MP0002735_abnormal_chemical_nociception1.61365794
32MP0008789_abnormal_olfactory_epithelium1.60799804
33MP0005551_abnormal_eye_electrophysiolog1.55405548
34MP0002557_abnormal_social/conspecific_i1.54588736
35MP0004142_abnormal_muscle_tone1.53581240
36MP0003123_paternal_imprinting1.52780227
37MP0003283_abnormal_digestive_organ1.48580576
38MP0005423_abnormal_somatic_nervous1.45931288
39MP0002184_abnormal_innervation1.43557680
40MP0000566_synostosis1.43150945
41MP0009379_abnormal_foot_pigmentation1.41013540
42MP0001970_abnormal_pain_threshold1.38546276
43MP0004924_abnormal_behavior1.38010543
44MP0005386_behavior/neurological_phenoty1.38010543
45MP0005248_abnormal_Harderian_gland1.37221933
46MP0006072_abnormal_retinal_apoptosis1.35925534
47MP0005187_abnormal_penis_morphology1.34460996
48MP0000049_abnormal_middle_ear1.33640508
49MP0004133_heterotaxia1.33468031
50MP0000955_abnormal_spinal_cord1.33388199
51MP0002733_abnormal_thermal_nociception1.33366007
52MP0001485_abnormal_pinna_reflex1.30328946
53MP0005499_abnormal_olfactory_system1.29785132
54MP0005394_taste/olfaction_phenotype1.29785132
55MP0002938_white_spotting1.29354864
56MP0002909_abnormal_adrenal_gland1.25539627
57MP0003938_abnormal_ear_development1.24176555
58MP0002638_abnormal_pupillary_reflex1.22262942
59MP0010030_abnormal_orbit_morphology1.21490727
60MP0002653_abnormal_ependyma_morphology1.20818324
61MP0000026_abnormal_inner_ear1.20390171
62MP0004742_abnormal_vestibular_system1.20332166
63MP0002234_abnormal_pharynx_morphology1.20107762
64MP0002067_abnormal_sensory_capabilities1.19777252
65MP0001984_abnormal_olfaction1.17626564
66MP0002882_abnormal_neuron_morphology1.17596092
67MP0003119_abnormal_digestive_system1.12920501
68MP0005253_abnormal_eye_physiology1.11717121
69MP0002751_abnormal_autonomic_nervous1.10970564
70MP0002152_abnormal_brain_morphology1.05927450
71MP0002233_abnormal_nose_morphology1.03807268
72MP0002752_abnormal_somatic_nervous1.03370942
73MP0003890_abnormal_embryonic-extraembry1.02889995
74MP0004811_abnormal_neuron_physiology1.01528405
75MP0001905_abnormal_dopamine_level0.97913670
76MP0003937_abnormal_limbs/digits/tail_de0.97850602
77MP0003861_abnormal_nervous_system0.96795249
78MP0004043_abnormal_pH_regulation0.96608845
79MP0000534_abnormal_ureter_morphology0.96371254
80MP0008872_abnormal_physiological_respon0.95236244
81MP0003755_abnormal_palate_morphology0.94989350
82MP0005645_abnormal_hypothalamus_physiol0.93732825
83MP0001299_abnormal_eye_distance/0.91250035
84MP0001440_abnormal_grooming_behavior0.91169660
85MP0005409_darkened_coat_color0.90252628
86MP0001501_abnormal_sleep_pattern0.89586952
87MP0001963_abnormal_hearing_physiology0.89010277
88MP0005195_abnormal_posterior_eye0.88880108
89MP0001177_atelectasis0.88083363
90MP0000569_abnormal_digit_pigmentation0.86411757
91MP0000647_abnormal_sebaceous_gland0.85273386
92MP0002066_abnormal_motor_capabilities/c0.84520505
93MP0000537_abnormal_urethra_morphology0.81588421
94MP0001986_abnormal_taste_sensitivity0.79674726
95MP0003942_abnormal_urinary_system0.77860220
96MP0001293_anophthalmia0.75397028
97MP0003879_abnormal_hair_cell0.74464441
98MP0001346_abnormal_lacrimal_gland0.74188725
99MP0002249_abnormal_larynx_morphology0.73219809
100MP0003385_abnormal_body_wall0.73194397

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.06260532
2Focal motor seizures (HP:0011153)4.74700303
3Focal seizures (HP:0007359)3.86846744
4Pancreatic fibrosis (HP:0100732)3.45576849
5Broad-based gait (HP:0002136)3.23335693
6Febrile seizures (HP:0002373)3.19922740
7True hermaphroditism (HP:0010459)3.17364989
8Drooling (HP:0002307)3.15565065
9Limb dystonia (HP:0002451)3.09727197
10Hemiparesis (HP:0001269)2.99930516
11Pancreatic cysts (HP:0001737)2.86315455
12Epileptic encephalopathy (HP:0200134)2.84597135
13Oligodactyly (hands) (HP:0001180)2.84179747
14Excessive salivation (HP:0003781)2.83805423
15Lissencephaly (HP:0001339)2.79944292
16Exotropia (HP:0000577)2.69443162
17Abnormality of the labia minora (HP:0012880)2.66945154
18Nephronophthisis (HP:0000090)2.63075402
19Polyphagia (HP:0002591)2.59962528
20Dialeptic seizures (HP:0011146)2.55989335
21Type II lissencephaly (HP:0007260)2.55797766
22Volvulus (HP:0002580)2.54416335
23Absence seizures (HP:0002121)2.53412653
24Macroorchidism (HP:0000053)2.47169816
25Abnormality of the renal medulla (HP:0100957)2.40013762
26Amblyopia (HP:0000646)2.39280935
27Abnormality of midbrain morphology (HP:0002418)2.37424557
28Molar tooth sign on MRI (HP:0002419)2.37424557
29Epileptiform EEG discharges (HP:0011182)2.37411400
30Polydipsia (HP:0001959)2.37184169
31Abnormal drinking behavior (HP:0030082)2.37184169
32Atonic seizures (HP:0010819)2.35911575
33Congenital stationary night blindness (HP:0007642)2.35348901
34Pachygyria (HP:0001302)2.34475879
35Generalized tonic-clonic seizures (HP:0002069)2.32941608
36Intestinal atresia (HP:0011100)2.31241767
37EEG with generalized epileptiform discharges (HP:0011198)2.30033673
38Myokymia (HP:0002411)2.27702580
39Bile duct proliferation (HP:0001408)2.26822406
40Abnormal biliary tract physiology (HP:0012439)2.26822406
41Hypsarrhythmia (HP:0002521)2.26758792
42Absent speech (HP:0001344)2.26281463
43Oligodactyly (HP:0012165)2.25467907
44Abnormality of the renal cortex (HP:0011035)2.21067455
45Cystic liver disease (HP:0006706)2.19500305
46Tubular atrophy (HP:0000092)2.18964765
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15605403
48Short 4th metacarpal (HP:0010044)2.15605403
49Optic nerve hypoplasia (HP:0000609)2.15371575
50Progressive cerebellar ataxia (HP:0002073)2.13969755
51Genital tract atresia (HP:0001827)2.12066178
52Aplasia/Hypoplasia of the tongue (HP:0010295)2.08434939
53Septo-optic dysplasia (HP:0100842)2.08155873
54Gait imbalance (HP:0002141)2.07711668
55Anencephaly (HP:0002323)2.04699631
56Protruding tongue (HP:0010808)2.03636566
57Chronic hepatic failure (HP:0100626)2.02855993
58Renal dysplasia (HP:0000110)2.00779988
59Medial flaring of the eyebrow (HP:0010747)1.98068309
60Abnormal rod and cone electroretinograms (HP:0008323)1.95956627
61Megalencephaly (HP:0001355)1.95599940
62Abnormal eating behavior (HP:0100738)1.95019689
63Abnormal hair whorl (HP:0010721)1.94385983
64Action tremor (HP:0002345)1.90234174
65Postaxial hand polydactyly (HP:0001162)1.88986773
66Abnormality of the 4th metacarpal (HP:0010012)1.87871169
67Vaginal atresia (HP:0000148)1.87007242
68Postaxial foot polydactyly (HP:0001830)1.85640556
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85147962
70Specific learning disability (HP:0001328)1.84603705
71Hepatoblastoma (HP:0002884)1.84211674
72Gaze-evoked nystagmus (HP:0000640)1.83743661
73Inability to walk (HP:0002540)1.83561639
74Bony spicule pigmentary retinopathy (HP:0007737)1.83227990
75Cerebellar dysplasia (HP:0007033)1.83008298
76Anophthalmia (HP:0000528)1.82658707
77Tented upper lip vermilion (HP:0010804)1.82384742
78Status epilepticus (HP:0002133)1.80742361
79Aqueductal stenosis (HP:0002410)1.78979386
80Methylmalonic acidemia (HP:0002912)1.77575080
81Narrow forehead (HP:0000341)1.75462558
82Scrotal hypoplasia (HP:0000046)1.73867997
83Renal hypoplasia (HP:0000089)1.73018975
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73008637
85Congenital primary aphakia (HP:0007707)1.70355103
86Dyskinesia (HP:0100660)1.69455351
87Agitation (HP:0000713)1.68381950
88Congenital hepatic fibrosis (HP:0002612)1.66737437
89Long foot (HP:0001833)1.66510364
90Concave nail (HP:0001598)1.66152623
91Fair hair (HP:0002286)1.66132335
92Nephrogenic diabetes insipidus (HP:0009806)1.65088932
93Progressive inability to walk (HP:0002505)1.62247336
94Gastrointestinal atresia (HP:0002589)1.62024613
95Hypoplastic ischia (HP:0003175)1.61041441
96Gastroesophageal reflux (HP:0002020)1.60103950
97Spastic tetraplegia (HP:0002510)1.60093842
98Prominent supraorbital ridges (HP:0000336)1.59751624
99Labial hypoplasia (HP:0000066)1.59082829
100Polyuria (HP:0000103)1.58967438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.14916496
2CASK3.53770236
3TAOK13.08962105
4FRK3.06335796
5PNCK2.95705946
6MAPK132.84381570
7EPHA42.68934828
8WNK32.68675530
9NTRK32.61389226
10TNIK2.25631430
11MAP3K42.14782433
12LATS12.01468354
13PINK11.94142830
14NTRK21.88672904
15BMPR1B1.71116234
16MAP4K21.65305616
17MAP2K71.64531894
18EPHB21.55769551
19MKNK21.53030770
20ZAK1.51825319
21PRKD31.49215239
22TGFBR21.41657403
23MINK11.38838385
24DYRK21.38743194
25PAK31.32911811
26CAMK1G1.32013219
27NUAK11.31565411
28PKN11.30165525
29DAPK21.25187426
30PRKCG1.24283273
31BCR1.23480086
32UHMK11.21925849
33CDK31.14999081
34STK38L1.14493898
35CSNK1G21.12593188
36PHKG11.06246876
37PHKG21.06246876
38CAMK11.04768575
39ADRBK21.04704329
40GRK11.03876316
41TRIM281.03249437
42WEE11.02956036
43PLK21.01056957
44VRK11.00213927
45INSRR0.99254817
46PRKCE0.97771579
47MAPK150.96903519
48CDC70.94679837
49SGK20.92144876
50TYRO30.91181936
51CAMK1D0.86176637
52SIK20.84840679
53AKT30.84569220
54CSNK1G30.83554610
55MAP3K90.83227058
56SGK2230.82979325
57SGK4940.82979325
58FGFR20.82883765
59CSNK1G10.82571550
60CSNK1A1L0.79497386
61CCNB10.76433659
62DYRK1A0.75481212
63STK110.71888148
64MAP2K40.70651239
65CDK50.69379973
66CAMK2A0.67830545
67MKNK10.67221482
68SGK10.64109241
69ERBB20.60163011
70DMPK0.59197068
71ERBB30.58244452
72CSNK1D0.57130211
73SRPK10.56118123
74PRKCZ0.55280441
75LATS20.54939322
76CAMK40.54500987
77PRKCH0.53956063
78WNK40.50154001
79DYRK30.48076959
80ROCK10.46460663
81PRKG10.46225010
82OXSR10.45080123
83PRKACA0.44745721
84OBSCN0.44479822
85CSNK1A10.43726579
86BRSK20.41913894
87VRK20.41588025
88CAMK2B0.38675393
89TLK10.38038046
90ADRBK10.37653696
91STK380.37443049
92CSNK1E0.36001833
93PKN20.35477317
94CAMKK10.35363006
95CDK180.35149792
96RPS6KA30.34888699
97PAK60.34685628
98CDK150.33976678
99CAMK2D0.32706322
100PLK30.32416312

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97991176
2Insulin secretion_Homo sapiens_hsa049112.51697459
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41698678
4Circadian entrainment_Homo sapiens_hsa047132.18135291
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12615718
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11763926
7Caffeine metabolism_Homo sapiens_hsa002322.06827151
8Phototransduction_Homo sapiens_hsa047442.05625443
9Cocaine addiction_Homo sapiens_hsa050302.00224081
10Glutamatergic synapse_Homo sapiens_hsa047241.94184315
11GABAergic synapse_Homo sapiens_hsa047271.88723387
12Morphine addiction_Homo sapiens_hsa050321.85353343
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82232945
14Amphetamine addiction_Homo sapiens_hsa050311.77057408
15Dopaminergic synapse_Homo sapiens_hsa047281.76389356
16Butanoate metabolism_Homo sapiens_hsa006501.70071082
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66220304
18Axon guidance_Homo sapiens_hsa043601.59358721
19Linoleic acid metabolism_Homo sapiens_hsa005911.58120965
20Steroid biosynthesis_Homo sapiens_hsa001001.57806693
21Basal cell carcinoma_Homo sapiens_hsa052171.48604874
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.47240777
23Sulfur relay system_Homo sapiens_hsa041221.43672578
24Taste transduction_Homo sapiens_hsa047421.42144192
25Long-term depression_Homo sapiens_hsa047301.41041229
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40250544
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40249947
28Propanoate metabolism_Homo sapiens_hsa006401.39794272
29Salivary secretion_Homo sapiens_hsa049701.35228458
30Hedgehog signaling pathway_Homo sapiens_hsa043401.32900109
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32311213
32Tryptophan metabolism_Homo sapiens_hsa003801.31691166
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30316432
34Renin secretion_Homo sapiens_hsa049241.28299438
35Cholinergic synapse_Homo sapiens_hsa047251.24576834
36Nitrogen metabolism_Homo sapiens_hsa009101.22576151
37cAMP signaling pathway_Homo sapiens_hsa040241.21233587
38Synaptic vesicle cycle_Homo sapiens_hsa047211.21001198
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17137949
40Cardiac muscle contraction_Homo sapiens_hsa042601.13955760
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12407800
42Serotonergic synapse_Homo sapiens_hsa047261.12064231
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11295193
44Protein export_Homo sapiens_hsa030601.07852181
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07257264
46Calcium signaling pathway_Homo sapiens_hsa040201.01117979
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00139372
48Olfactory transduction_Homo sapiens_hsa047400.99567301
49Gastric acid secretion_Homo sapiens_hsa049710.98346935
50Oxytocin signaling pathway_Homo sapiens_hsa049210.97621783
51Non-homologous end-joining_Homo sapiens_hsa034500.95393703
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.94970954
53Folate biosynthesis_Homo sapiens_hsa007900.94870265
54Ether lipid metabolism_Homo sapiens_hsa005650.90857445
55Wnt signaling pathway_Homo sapiens_hsa043100.88755096
56Fatty acid biosynthesis_Homo sapiens_hsa000610.86839442
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83274451
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80759623
59Hippo signaling pathway_Homo sapiens_hsa043900.79968007
60Melanogenesis_Homo sapiens_hsa049160.79843858
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79839083
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79802305
63Gap junction_Homo sapiens_hsa045400.76698246
64beta-Alanine metabolism_Homo sapiens_hsa004100.76622043
65Retinol metabolism_Homo sapiens_hsa008300.74476811
66Circadian rhythm_Homo sapiens_hsa047100.74362843
67Fatty acid metabolism_Homo sapiens_hsa012120.69755980
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69015307
69Long-term potentiation_Homo sapiens_hsa047200.68100826
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66876918
71Oxidative phosphorylation_Homo sapiens_hsa001900.66321030
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.65380351
73Glycerolipid metabolism_Homo sapiens_hsa005610.63679905
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.62338531
75Ovarian steroidogenesis_Homo sapiens_hsa049130.58177189
76Basal transcription factors_Homo sapiens_hsa030220.57665777
77Bile secretion_Homo sapiens_hsa049760.56018729
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55966533
79Dorso-ventral axis formation_Homo sapiens_hsa043200.55746644
80Dilated cardiomyopathy_Homo sapiens_hsa054140.53918917
81TGF-beta signaling pathway_Homo sapiens_hsa043500.52640503
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52214987
83Huntingtons disease_Homo sapiens_hsa050160.51728082
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51210871
85Alzheimers disease_Homo sapiens_hsa050100.51122012
86Pancreatic secretion_Homo sapiens_hsa049720.51005859
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49281214
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49188706
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46932346
90Glucagon signaling pathway_Homo sapiens_hsa049220.46726794
91Parkinsons disease_Homo sapiens_hsa050120.46003477
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.45507924
93Type II diabetes mellitus_Homo sapiens_hsa049300.45331997
94Thyroid hormone synthesis_Homo sapiens_hsa049180.45018472
95Chemical carcinogenesis_Homo sapiens_hsa052040.44972825
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43334894
97Fanconi anemia pathway_Homo sapiens_hsa034600.41172047
98Alcoholism_Homo sapiens_hsa050340.40699432
99Estrogen signaling pathway_Homo sapiens_hsa049150.40000558
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39664499

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »