TTC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains tetratricopeptide (TPR) repeats, which often mediate protein-protein interactions and chaperone activity. The encoded protein interacts with heat shock proteins 70 and 90. Alternative splicing results in multiple transcript variants. Naturally-occuring readthrough transcription occurs from upstream gene MROH (maestro heat-like repeat family member 7) to this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosome assembly (GO:0042255)4.65641059
2mitotic metaphase plate congression (GO:0007080)4.55909597
3DNA strand elongation involved in DNA replication (GO:0006271)4.23463463
4cullin deneddylation (GO:0010388)4.16003851
5maturation of SSU-rRNA (GO:0030490)4.07414472
6purine nucleobase biosynthetic process (GO:0009113)4.07063700
7nucleobase biosynthetic process (GO:0046112)4.02705631
8DNA strand elongation (GO:0022616)4.02180558
9telomere maintenance via semi-conservative replication (GO:0032201)4.01605810
10folic acid-containing compound biosynthetic process (GO:0009396)3.90448859
11mitotic sister chromatid segregation (GO:0000070)3.88302454
12metaphase plate congression (GO:0051310)3.87917496
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.86690617
14establishment of viral latency (GO:0019043)3.81008620
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.73864127
16protein deneddylation (GO:0000338)3.73567634
17ribosomal small subunit assembly (GO:0000028)3.72877240
18regulation of helicase activity (GO:0051095)3.68767332
19DNA replication initiation (GO:0006270)3.67390555
20DNA double-strand break processing (GO:0000729)3.66589752
21proteasome assembly (GO:0043248)3.64271502
22DNA ligation (GO:0006266)3.60991670
23telomere maintenance via recombination (GO:0000722)3.60965423
24establishment of integrated proviral latency (GO:0075713)3.60932985
25binding of sperm to zona pellucida (GO:0007339)3.59833605
26IMP biosynthetic process (GO:0006188)3.54690520
27protein localization to kinetochore (GO:0034501)3.54665785
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.50650372
29DNA deamination (GO:0045006)3.49141936
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.47953904
31RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.47953904
32microtubule depolymerization (GO:0007019)3.45597327
33sister chromatid segregation (GO:0000819)3.45262799
34sperm-egg recognition (GO:0035036)3.43498366
35histone H2A acetylation (GO:0043968)3.40375183
36maturation of 5.8S rRNA (GO:0000460)3.40195860
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.39752856
38viral mRNA export from host cell nucleus (GO:0046784)3.37599190
39double-strand break repair via nonhomologous end joining (GO:0006303)3.36743193
40non-recombinational repair (GO:0000726)3.36743193
41mitotic recombination (GO:0006312)3.35790239
42pteridine-containing compound biosynthetic process (GO:0042559)3.35498327
43nuclear pore complex assembly (GO:0051292)3.33892446
44anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.33100008
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32957219
46DNA catabolic process, exonucleolytic (GO:0000738)3.32519604
47rRNA methylation (GO:0031167)3.31786360
48piRNA metabolic process (GO:0034587)3.27852214
49L-serine metabolic process (GO:0006563)3.27176522
50DNA replication checkpoint (GO:0000076)3.27044063
51DNA unwinding involved in DNA replication (GO:0006268)3.26172335
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.24255561
53NADH dehydrogenase complex assembly (GO:0010257)3.24255561
54mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24255561
55protein targeting to mitochondrion (GO:0006626)3.24072513
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23516989
57negative regulation of ligase activity (GO:0051352)3.23516989
58UTP biosynthetic process (GO:0006228)3.21782606
59telomere maintenance via telomere lengthening (GO:0010833)3.19559702
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.19517821
61establishment of chromosome localization (GO:0051303)3.19122704
62regulation of ligase activity (GO:0051340)3.18456896
63ribosome biogenesis (GO:0042254)3.18436943
64spindle checkpoint (GO:0031577)3.18342528
65pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.18153641
66CENP-A containing nucleosome assembly (GO:0034080)3.17710111
67chromatin remodeling at centromere (GO:0031055)3.16037476
68mitotic spindle checkpoint (GO:0071174)3.16023200
69transcription-coupled nucleotide-excision repair (GO:0006283)3.15308168
707-methylguanosine mRNA capping (GO:0006370)3.14658246
71mitochondrial RNA metabolic process (GO:0000959)3.14252097
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.14105957
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.14105957
74regulation of mitochondrial translation (GO:0070129)3.13823303
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13251178
76protein localization to chromosome, centromeric region (GO:0071459)3.13112297
77mitotic nuclear envelope disassembly (GO:0007077)3.12645366
78IMP metabolic process (GO:0046040)3.11713745
79protein K6-linked ubiquitination (GO:0085020)3.11593142
80protein-cofactor linkage (GO:0018065)3.09511904
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09210838
82negative regulation of mitotic sister chromatid separation (GO:2000816)3.07522525
83negative regulation of sister chromatid segregation (GO:0033046)3.07522525
84negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07522525
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07522525
86negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07522525
87negative regulation of chromosome segregation (GO:0051985)3.06111645
88tRNA methylation (GO:0030488)3.05417602
89formation of translation preinitiation complex (GO:0001731)3.05268562
90respiratory chain complex IV assembly (GO:0008535)3.03977059
91RNA capping (GO:0036260)3.03244205
927-methylguanosine RNA capping (GO:0009452)3.03244205
93GTP biosynthetic process (GO:0006183)3.03234573
94DNA damage response, detection of DNA damage (GO:0042769)3.03180125
95nucleobase-containing small molecule interconversion (GO:0015949)3.02873756
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.01854474
97mitochondrial respiratory chain complex assembly (GO:0033108)3.00986417
98chaperone-mediated protein transport (GO:0072321)3.00920957
99deoxyribonucleotide biosynthetic process (GO:0009263)3.00901354
100protein complex biogenesis (GO:0070271)3.00695871
101protein localization to mitochondrion (GO:0070585)3.00449746
102nuclear pore organization (GO:0006999)2.99750505
103cell-cell recognition (GO:0009988)2.99561031
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99022481
105signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99022481
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.98868181
107termination of RNA polymerase III transcription (GO:0006386)2.98868181
108transcription elongation from RNA polymerase I promoter (GO:0006362)2.97594160
109signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96241320
110signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96241320
111signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96241320
112mismatch repair (GO:0006298)2.95018371
113spliceosomal complex assembly (GO:0000245)2.94519243
114regulation of cellular amino acid metabolic process (GO:0006521)2.92273866
115positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90792723
116termination of RNA polymerase I transcription (GO:0006363)2.88687916
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.88624192
118signal transduction involved in DNA damage checkpoint (GO:0072422)2.88624192
119rRNA modification (GO:0000154)2.88300426
120histone exchange (GO:0043486)2.88163539
121peptidyl-histidine modification (GO:0018202)2.87398255
122cilium or flagellum-dependent cell motility (GO:0001539)2.87136715
123signal transduction involved in cell cycle checkpoint (GO:0072395)2.84485182
124regulation of cilium movement (GO:0003352)2.82879671
125guanosine-containing compound biosynthetic process (GO:1901070)2.82684279
126negative regulation of DNA recombination (GO:0045910)2.81482210
127sperm motility (GO:0030317)2.81157102
128positive regulation of ligase activity (GO:0051351)2.79523874
129spliceosomal snRNP assembly (GO:0000387)2.78124827
130pseudouridine synthesis (GO:0001522)2.78084942
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77941823
132somatic diversification of immunoglobulins (GO:0016445)2.77328772
133oxidative phosphorylation (GO:0006119)2.76615124
134axonemal dynein complex assembly (GO:0070286)2.75460098
135ribonucleoprotein complex biogenesis (GO:0022613)2.75235582
136G1/S transition of mitotic cell cycle (GO:0000082)2.74279102
137cell cycle G1/S phase transition (GO:0044843)2.74279102
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.73431148
139DNA replication-independent nucleosome assembly (GO:0006336)2.72337999
140DNA replication-independent nucleosome organization (GO:0034724)2.72337999
141rRNA processing (GO:0006364)2.72250395
142postreplication repair (GO:0006301)2.71569654
143metallo-sulfur cluster assembly (GO:0031163)2.71417164
144iron-sulfur cluster assembly (GO:0016226)2.71417164
145cellular component biogenesis (GO:0044085)2.71334701
146somatic recombination of immunoglobulin gene segments (GO:0016447)2.71307410
147DNA methylation involved in gamete generation (GO:0043046)2.70833479
148deoxyribose phosphate biosynthetic process (GO:0046385)2.70377156

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47816936
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91675787
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.82937379
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.74998944
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.66472686
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.51991906
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.42110167
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.10046553
9* GABP_17652178_ChIP-ChIP_JURKAT_Human3.10035489
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.04934069
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99137808
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.90080278
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88326067
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.83551343
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.80163026
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.69392491
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64529706
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.63194573
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62137651
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53708946
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.52648853
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.51364241
23* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45509477
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37564849
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.34975572
26* VDR_23849224_ChIP-Seq_CD4+_Human2.27581356
27ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.26254417
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10851785
29XRN2_22483619_ChIP-Seq_HELA_Human2.03616709
30* GABP_19822575_ChIP-Seq_HepG2_Human2.03472440
31FOXP3_21729870_ChIP-Seq_TREG_Human2.00596216
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.98685926
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94488715
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94385663
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.93919324
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91176933
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88411917
38DCP1A_22483619_ChIP-Seq_HELA_Human1.87655337
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.83361484
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.79682886
41YY1_21170310_ChIP-Seq_MESCs_Mouse1.76518439
42* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74902895
43* TTF2_22483619_ChIP-Seq_HELA_Human1.73415321
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72706165
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.71903429
46CIITA_25753668_ChIP-Seq_RAJI_Human1.70139486
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52505698
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50355231
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48849505
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.47996196
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.47813639
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37841720
53ELK1_19687146_ChIP-ChIP_HELA_Human1.37187596
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37171813
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36185235
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34739526
57AR_21909140_ChIP-Seq_LNCAP_Human1.31805254
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.28391856
59KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25968883
60TFEB_21752829_ChIP-Seq_HELA_Human1.19688926
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19662379
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16951741
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16838502
64NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15752184
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15343983
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14374283
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14051685
68MYC_18940864_ChIP-ChIP_HL60_Human1.13047718
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11248142
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09188620
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.07364073
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04964854
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03875195
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.01629900
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00300236
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99980595
77* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99390420
78SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98435996
79STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97997904
80EZH2_22144423_ChIP-Seq_EOC_Human0.97616566
81* KDM5A_27292631_Chip-Seq_BREAST_Human0.97237475
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96492514
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95757704
84SOX17_20123909_ChIP-Seq_XEN_Mouse0.94457162
85* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93358296
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.92843713
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91875702
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91787111
89SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90380690
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89574538
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.88253631
92CTCF_18555785_ChIP-Seq_MESCs_Mouse0.84880439
93IRF1_19129219_ChIP-ChIP_H3396_Human0.83056882
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83054538
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83022635
96HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82831660
97SALL1_21062744_ChIP-ChIP_HESCs_Human0.81189779
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79729932
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79049042
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78250733
101EWS_26573619_Chip-Seq_HEK293_Human0.77760551
102FUS_26573619_Chip-Seq_HEK293_Human0.77744161
103VDR_22108803_ChIP-Seq_LS180_Human0.77377653
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.75881071
105IGF1R_20145208_ChIP-Seq_DFB_Human0.75598607
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75150642
107CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74907521
108FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73141250
109EGR1_19374776_ChIP-ChIP_THP-1_Human0.73106372
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73066397
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72651813
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.71784021
113ELF5_23300383_ChIP-Seq_T47D_Human0.71343737
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.71099936
115YY1_22570637_ChIP-Seq_MALME-3M_Human0.69878175
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.69822605
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69814767
118FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.68449633
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.66897383
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66486492
121CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.65860373

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.84665823
2MP0003693_abnormal_embryo_hatching3.82270887
3MP0008057_abnormal_DNA_replication3.78440160
4MP0008877_abnormal_DNA_methylation3.54134475
5MP0008058_abnormal_DNA_repair3.44318525
6MP0003123_paternal_imprinting3.35140067
7MP0005410_abnormal_fertilization3.31398681
8MP0003111_abnormal_nucleus_morphology3.19928420
9MP0009697_abnormal_copulation2.99835002
10MP0003941_abnormal_skin_development2.76886416
11MP0004957_abnormal_blastocyst_morpholog2.76865215
12MP0003077_abnormal_cell_cycle2.67446559
13MP0008007_abnormal_cellular_replicative2.49750698
14MP0003186_abnormal_redox_activity2.49145742
15MP0006292_abnormal_olfactory_placode2.08037681
16MP0001929_abnormal_gametogenesis2.05216728
17MP0003121_genomic_imprinting1.95946877
18MP0003698_abnormal_male_reproductive1.93854365
19MP0003122_maternal_imprinting1.93677524
20MP0008932_abnormal_embryonic_tissue1.88585305
21MP0002210_abnormal_sex_determination1.82398449
22MP0001529_abnormal_vocalization1.82319811
23MP0002163_abnormal_gland_morphology1.81990987
24MP0010307_abnormal_tumor_latency1.75416762
25MP0003787_abnormal_imprinting1.73874582
26MP0003880_abnormal_central_pattern1.70071140
27MP0003786_premature_aging1.69183330
28MP0001984_abnormal_olfaction1.54520832
29MP0006035_abnormal_mitochondrial_morpho1.52638272
30MP0001145_abnormal_male_reproductive1.51241818
31MP0002160_abnormal_reproductive_system1.49879871
32MP0001188_hyperpigmentation1.48558941
33MP0002396_abnormal_hematopoietic_system1.48416854
34MP0006036_abnormal_mitochondrial_physio1.47693937
35MP0010030_abnormal_orbit_morphology1.45280430
36MP0004147_increased_porphyrin_level1.42815325
37MP0004133_heterotaxia1.42157886
38MP0000749_muscle_degeneration1.41348473
39MP0001986_abnormal_taste_sensitivity1.37947178
40MP0008789_abnormal_olfactory_epithelium1.36401562
41MP0002736_abnormal_nociception_after1.36295259
42MP0000653_abnormal_sex_gland1.34143021
43MP0002638_abnormal_pupillary_reflex1.33599209
44MP0003806_abnormal_nucleotide_metabolis1.32422852
45MP0001968_abnormal_touch/_nociception1.32045897
46MP0009046_muscle_twitch1.31418075
47MP0002653_abnormal_ependyma_morphology1.30552518
48MP0008260_abnormal_autophagy1.27335925
49MP0005646_abnormal_pituitary_gland1.26842864
50MP0004859_abnormal_synaptic_plasticity1.23548224
51MP0003937_abnormal_limbs/digits/tail_de1.19021035
52MP0005379_endocrine/exocrine_gland_phen1.18138127
53MP0003635_abnormal_synaptic_transmissio1.17952031
54MP0003183_abnormal_peptide_metabolism1.17528976
55MP0000647_abnormal_sebaceous_gland1.17504032
56MP0004142_abnormal_muscle_tone1.15414647
57MP0002161_abnormal_fertility/fecundity1.15394918
58MP0002085_abnormal_embryonic_tissue1.13853620
59MP0005423_abnormal_somatic_nervous1.11567861
60MP0002272_abnormal_nervous_system1.11460151
61MP0001730_embryonic_growth_arrest1.09763734
62MP0002837_dystrophic_cardiac_calcinosis1.09289053
63MP0004233_abnormal_muscle_weight1.08827870
64MP0000015_abnormal_ear_pigmentation1.07364390
65MP0000313_abnormal_cell_death1.02110367
66MP0005367_renal/urinary_system_phenotyp1.00948610
67MP0000516_abnormal_urinary_system1.00948610
68MP0001293_anophthalmia1.00627503
69MP0005389_reproductive_system_phenotype1.00432420
70MP0000358_abnormal_cell_content/1.00358382
71MP0009672_abnormal_birth_weight1.00144546
72MP0000372_irregular_coat_pigmentation1.00049680
73MP0002084_abnormal_developmental_patter0.99236733
74MP0002233_abnormal_nose_morphology0.98513337
75MP0009745_abnormal_behavioral_response0.98428827
76MP0000350_abnormal_cell_proliferation0.96141997
77MP0002111_abnormal_tail_morphology0.96082971
78MP0003984_embryonic_growth_retardation0.95060066
79MP0008995_early_reproductive_senescence0.94782981
80MP0003718_maternal_effect0.94684007
81MP0006054_spinal_hemorrhage0.94379881
82MP0002064_seizures0.94119667
83MP0001853_heart_inflammation0.93950313
84MP0002088_abnormal_embryonic_growth/wei0.92876581
85MP0005645_abnormal_hypothalamus_physiol0.91770488
86MP0006072_abnormal_retinal_apoptosis0.91626491
87MP0001661_extended_life_span0.90420431
88MP0003136_yellow_coat_color0.89628681
89MP0002572_abnormal_emotion/affect_behav0.89500183
90MP0004084_abnormal_cardiac_muscle0.89249341
91MP0001346_abnormal_lacrimal_gland0.87796563
92MP0003890_abnormal_embryonic-extraembry0.86539802
93MP0000490_abnormal_crypts_of0.85531196
94MP0005075_abnormal_melanosome_morpholog0.83950924
95MP0004215_abnormal_myocardial_fiber0.83930827
96MP0002063_abnormal_learning/memory/cond0.83892581
97MP0002067_abnormal_sensory_capabilities0.82834559
98MP0005266_abnormal_metabolism0.82539153
99MP0002095_abnormal_skin_pigmentation0.82324346
100MP0002938_white_spotting0.81677525
101MP0000631_abnormal_neuroendocrine_gland0.81500059
102MP0004808_abnormal_hematopoietic_stem0.81186161
103MP0003950_abnormal_plasma_membrane0.79952728
104MP0002080_prenatal_lethality0.79948158
105MP0010352_gastrointestinal_tract_polyps0.79454449
106MP0002282_abnormal_trachea_morphology0.78276681
107MP0005174_abnormal_tail_pigmentation0.78242523
108MP0005395_other_phenotype0.77934012
109MP0002090_abnormal_vision0.77637470
110MP0003943_abnormal_hepatobiliary_system0.77561940
111MP0001764_abnormal_homeostasis0.77282702
112MP0003705_abnormal_hypodermis_morpholog0.77207291
113MP0002735_abnormal_chemical_nociception0.77032752
114MP0003763_abnormal_thymus_physiology0.76790302
115MP0009703_decreased_birth_body0.76729231
116MP0002876_abnormal_thyroid_physiology0.76258609
117MP0004811_abnormal_neuron_physiology0.76016081
118MP0001849_ear_inflammation0.75537152
119MP0001697_abnormal_embryo_size0.75499085
120MP0001905_abnormal_dopamine_level0.75200749
121MP0005187_abnormal_penis_morphology0.73414200
122MP0001119_abnormal_female_reproductive0.72859425
123MP0003315_abnormal_perineum_morphology0.72429855
124MP0005499_abnormal_olfactory_system0.72394353
125MP0005394_taste/olfaction_phenotype0.72394353
126MP0002132_abnormal_respiratory_system0.70444440
127MP0001672_abnormal_embryogenesis/_devel0.69963238
128MP0005380_embryogenesis_phenotype0.69963238
129MP0003755_abnormal_palate_morphology0.69898045
130MP0008569_lethality_at_weaning0.69840272
131MP0002734_abnormal_mechanical_nocicepti0.68638596
132MP0002697_abnormal_eye_size0.68195149
133MP0000762_abnormal_tongue_morphology0.67904655
134MP0002234_abnormal_pharynx_morphology0.67482185
135MP0002184_abnormal_innervation0.67421035
136MP0005384_cellular_phenotype0.67274743
137MP0004145_abnormal_muscle_electrophysio0.67153131
138MP0003221_abnormal_cardiomyocyte_apopto0.66410178
139MP0005330_cardiomyopathy0.65418547
140MP0002751_abnormal_autonomic_nervous0.64410581
141MP0008873_increased_physiological_sensi0.64104357
142MP0002254_reproductive_system_inflammat0.63965155
143MP0004036_abnormal_muscle_relaxation0.63907464
144MP0009250_abnormal_appendicular_skeleto0.63558920
145MP0002086_abnormal_extraembryonic_tissu0.63204822
146MP0000537_abnormal_urethra_morphology0.61583647
147MP0001727_abnormal_embryo_implantation0.61376837
148MP0002557_abnormal_social/conspecific_i0.60009719
149MP0000343_altered_response_to0.59997232
150MP0005408_hypopigmentation0.59963330
151MP0002019_abnormal_tumor_incidence0.59859738
152MP0001286_abnormal_eye_development0.59823908
153MP0003646_muscle_fatigue0.59792520
154MP0002269_muscular_atrophy0.59440462
155MP0005623_abnormal_meninges_morphology0.56061090
156MP0002102_abnormal_ear_morphology0.55998387

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)3.88652510
2Lipid accumulation in hepatocytes (HP:0006561)3.80091711
3Dynein arm defect of respiratory motile cilia (HP:0012255)3.57098172
4Absent/shortened dynein arms (HP:0200106)3.57098172
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.41523470
6Hepatocellular necrosis (HP:0001404)3.39344097
7Abnormal respiratory epithelium morphology (HP:0012253)3.36553022
8Abnormal respiratory motile cilium morphology (HP:0005938)3.36553022
9Renal Fanconi syndrome (HP:0001994)3.35470042
10Supernumerary spleens (HP:0009799)3.19410778
11Abnormal number of erythroid precursors (HP:0012131)3.07863615
12Microvesicular hepatic steatosis (HP:0001414)3.07103265
13Increased CSF lactate (HP:0002490)3.02769932
14Acute necrotizing encephalopathy (HP:0006965)2.99706280
15Mitochondrial inheritance (HP:0001427)2.99191070
16Medial flaring of the eyebrow (HP:0010747)2.98090598
17Abnormal mitochondria in muscle tissue (HP:0008316)2.97700982
18Abnormality of cells of the erythroid lineage (HP:0012130)2.97393953
19Aplastic anemia (HP:0001915)2.95913993
20Multiple enchondromatosis (HP:0005701)2.95223570
21Increased serum lactate (HP:0002151)2.87435343
22Abnormal respiratory motile cilium physiology (HP:0012261)2.83089453
23Pancreatic fibrosis (HP:0100732)2.83011129
24Type 2 muscle fiber atrophy (HP:0003554)2.79907183
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.76860660
26Nephrogenic diabetes insipidus (HP:0009806)2.75778451
27True hermaphroditism (HP:0010459)2.73031378
28Gait imbalance (HP:0002141)2.70119005
29Congenital primary aphakia (HP:0007707)2.65680207
30Hepatic necrosis (HP:0002605)2.64370306
31Increased intramyocellular lipid droplets (HP:0012240)2.64183024
32Abnormality of methionine metabolism (HP:0010901)2.64000010
33Hyperalaninemia (HP:0003348)2.63346575
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63346575
35Abnormality of alanine metabolism (HP:0010916)2.63346575
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62530351
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62530351
38Rhinitis (HP:0012384)2.61209416
39Severe visual impairment (HP:0001141)2.58464380
40Duodenal stenosis (HP:0100867)2.57838192
41Small intestinal stenosis (HP:0012848)2.57838192
42Secondary amenorrhea (HP:0000869)2.56454774
433-Methylglutaconic aciduria (HP:0003535)2.55869614
44Abnormal ciliary motility (HP:0012262)2.55585272
45Medulloblastoma (HP:0002885)2.54199892
46Abnormality of serum amino acid levels (HP:0003112)2.49898832
47Muscle fiber atrophy (HP:0100295)2.46899346
48Abnormality of placental membranes (HP:0011409)2.45964426
49Amniotic constriction ring (HP:0009775)2.45964426
50Horseshoe kidney (HP:0000085)2.45582993
51Exertional dyspnea (HP:0002875)2.45227555
52Abnormal hair whorl (HP:0010721)2.44757023
53Ependymoma (HP:0002888)2.43231670
54Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42464738
5511 pairs of ribs (HP:0000878)2.39910549
56Cerebral edema (HP:0002181)2.38290559
57Lactic acidosis (HP:0003128)2.37627247
58Progressive macrocephaly (HP:0004481)2.36367495
59Reticulocytopenia (HP:0001896)2.34926704
60Respiratory difficulties (HP:0002880)2.33501206
61Type I transferrin isoform profile (HP:0003642)2.32583010
62Abnormality of glycolysis (HP:0004366)2.31969714
63Increased serum pyruvate (HP:0003542)2.31969714
64Pancreatic cysts (HP:0001737)2.30318395
65Acute encephalopathy (HP:0006846)2.29579186
66Nephroblastoma (Wilms tumor) (HP:0002667)2.29350971
67Chronic bronchitis (HP:0004469)2.28717671
68Rhabdomyosarcoma (HP:0002859)2.26784829
69Poor suck (HP:0002033)2.23207772
70Short middle phalanx of the 5th finger (HP:0004220)2.22557531
71Respiratory failure (HP:0002878)2.21862668
72Cholecystitis (HP:0001082)2.21015049
73Abnormal gallbladder physiology (HP:0012438)2.21015049
74Postnatal microcephaly (HP:0005484)2.19547025
75Abnormal lung lobation (HP:0002101)2.18513376
76Impulsivity (HP:0100710)2.18275466
77Abnormality of the duodenum (HP:0002246)2.18245162
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.17881978
79Increased muscle lipid content (HP:0009058)2.16599239
80Gonadotropin excess (HP:0000837)2.16427682
81Cerebral hypomyelination (HP:0006808)2.15394640
82Agnosia (HP:0010524)2.15294861
83Embryonal renal neoplasm (HP:0011794)2.15220880
84Abnormalities of placenta or umbilical cord (HP:0001194)2.14896817
85Sloping forehead (HP:0000340)2.13774628
86Poor coordination (HP:0002370)2.13310762
87Abnormality of the umbilical cord (HP:0010881)2.11990903
88Abnormal spermatogenesis (HP:0008669)2.08365355
89Pancytopenia (HP:0001876)2.08007646
90Molar tooth sign on MRI (HP:0002419)2.07824577
91Abnormality of midbrain morphology (HP:0002418)2.07824577
92Degeneration of anterior horn cells (HP:0002398)2.07497401
93Abnormality of the anterior horn cell (HP:0006802)2.07497401
94Abnormal umbilical cord blood vessels (HP:0011403)2.07149737
95Single umbilical artery (HP:0001195)2.07149737
96Abnormality of the fetal cardiovascular system (HP:0010948)2.07149737
97Nephronophthisis (HP:0000090)2.05391852
98Glioma (HP:0009733)2.05149708
99Premature ovarian failure (HP:0008209)2.04923154
100Abnormal protein glycosylation (HP:0012346)2.03506040
101Abnormal glycosylation (HP:0012345)2.03506040
102Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03506040
103Abnormal protein N-linked glycosylation (HP:0012347)2.03506040
104Progressive muscle weakness (HP:0003323)2.03178771
105Exercise intolerance (HP:0003546)2.03144817
106Bifid tongue (HP:0010297)2.02704031
107Abnormality of the preputium (HP:0100587)2.01820445
108Postaxial foot polydactyly (HP:0001830)2.01643624
109Abnormality of aspartate family amino acid metabolism (HP:0010899)2.01524267
110Unsteady gait (HP:0002317)2.01052785
111Abnormality of the labia minora (HP:0012880)1.99724839
112Meckel diverticulum (HP:0002245)1.98288161
113Breast hypoplasia (HP:0003187)1.97854771
114Absent thumb (HP:0009777)1.96409639
115Abnormality of the ileum (HP:0001549)1.94768290
116Bone marrow hypocellularity (HP:0005528)1.94520754
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94108675
118Rough bone trabeculation (HP:0100670)1.93331051
119Abnormality of the carotid arteries (HP:0005344)1.92712788
120Triphalangeal thumb (HP:0001199)1.91597194
121Lissencephaly (HP:0001339)1.87762940
122Hyperglycinemia (HP:0002154)1.87433117
123Increased hepatocellular lipid droplets (HP:0006565)1.87171058
124Abnormality of chromosome stability (HP:0003220)1.87055728
125Emotional lability (HP:0000712)1.86617912
126Ectopic kidney (HP:0000086)1.86282517
127Cortical dysplasia (HP:0002539)1.85758939
128Colon cancer (HP:0003003)1.85395765
129Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84867912
130Neoplasm of the colon (HP:0100273)1.83927529
131Chromsome breakage (HP:0040012)1.83344429
132Asplenia (HP:0001746)1.83180862
133Aplasia/Hypoplasia of the uvula (HP:0010293)1.82512843
134Reduced antithrombin III activity (HP:0001976)1.82363111
135CNS demyelination (HP:0007305)1.82106022
136Diastasis recti (HP:0001540)1.81506525
137Methylmalonic aciduria (HP:0012120)1.81311040
138Occipital encephalocele (HP:0002085)1.81305354
139Genital tract atresia (HP:0001827)1.81050262
140Abnormality of sulfur amino acid metabolism (HP:0004339)1.80521425
141Myelodysplasia (HP:0002863)1.80466622
142Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80313651
143Absent epiphyses (HP:0010577)1.80313651
144Poor head control (HP:0002421)1.78625244
145Chromosomal breakage induced by crosslinking agents (HP:0003221)1.77316383
146Broad foot (HP:0001769)1.76786883
147Vaginal atresia (HP:0000148)1.75330445
148Oral leukoplakia (HP:0002745)1.74379709
149Carpal bone hypoplasia (HP:0001498)1.73994240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.72993524
2CCNB13.58061485
3TRIM283.41811637
4BUB13.08554291
5PBK2.97499858
6STK162.79248598
7CDC72.78959051
8VRK12.70955224
9TSSK62.69812745
10NEK12.59889329
11PDK32.58982658
12PDK42.58982658
13CASK2.57750590
14CDK82.49706225
15VRK22.34335881
16MST42.13003309
17ACVR1B2.09790580
18BRSK22.01241188
19BRSK12.00856984
20SRPK12.00764477
21WNK31.89303318
22PRKD31.87660451
23PASK1.82034461
24NUAK11.75267736
25MAP2K71.69692537
26PLK31.68042435
27MKNK11.67146951
28TNIK1.56756016
29NEK21.55888539
30EIF2AK11.55018528
31EIF2AK31.49455318
32PDK21.48293154
33MAPK131.43297233
34PLK11.40683344
35ATR1.36889894
36BMPR1B1.36776261
37PAK41.36714926
38IRAK31.35075886
39AKT31.31763003
40MAP3K41.30876430
41NME11.27658315
42PLK41.20178587
43TGFBR11.19383505
44FLT31.14597595
45MARK31.08542188
46MAP3K121.05825502
47CDK191.02477565
48NEK61.02375697
49CDK70.99458365
50NTRK30.98483973
51BRD40.96979290
52PNCK0.96401660
53CHEK20.94047437
54TAF10.93321495
55MKNK20.92221122
56DAPK10.90118141
57DYRK30.89051649
58SIK30.84898790
59PLK20.84882462
60BCR0.83879206
61YES10.81115781
62TESK10.80495631
63BRAF0.79008361
64CSNK1G10.78468291
65KIT0.77951807
66CSNK1G30.76804013
67AURKB0.75159789
68TTK0.75035290
69STK100.74731493
70EPHA40.74625963
71ERBB30.74276835
72AURKA0.73299022
73PRKG20.72023300
74TXK0.71449602
75PRPF4B0.71362361
76RPS6KB10.71244264
77STK240.70031644
78DYRK20.63650959
79CHEK10.60011273
80TLK10.59528927
81NME20.59520156
82MYLK0.59248682
83ZAK0.58507393
84ATM0.56850126
85CSNK2A10.56807713
86ABL20.56061900
87CSNK2A20.55791017
88PKN10.55209959
89MAP3K80.55124279
90MAP3K30.52221777
91STK40.52124786
92ADRBK20.51725449
93BMPR20.51591924
94MINK10.51487349
95PIK3CA0.51466393
96PIM20.50949236
97CSNK1A1L0.49616453
98CDK40.49466790
99RPS6KB20.49185305
100ILK0.48988139
101ERBB40.47898505
102CDK20.47450351
103MAPKAPK50.47366715
104MUSK0.47123208
105BCKDK0.46833724
106PRKCG0.46517619
107MARK10.46361944
108PAK10.45877212
109CDK10.45117123
110ALK0.45080040
111AKT20.45041214
112PRKCI0.42346710
113BTK0.41567000
114STK30.40883092
115MAP4K10.40282134
116CSF1R0.38888425
117NTRK20.38521216
118CDK180.38320688
119OBSCN0.37229561
120CSNK1G20.36712637
121EIF2AK20.36468567
122ARAF0.35686211
123DYRK1A0.35361116
124TESK20.35160635
125SCYL20.34645841
126TEC0.34361809
127CDK11A0.34061606
128TAOK20.33753391
129PRKACB0.32358239
130MAPKAPK30.28796534
131PRKDC0.26354895
132CSNK1E0.25947950
133RAF10.24765181
134FGFR10.24702391
135RPS6KA40.24677183
136DAPK30.23907742
137CDK90.22098099
138DMPK0.20004420
139FGR0.19378296

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.49768613
2Mismatch repair_Homo sapiens_hsa034304.42117683
3Proteasome_Homo sapiens_hsa030503.84108725
4RNA polymerase_Homo sapiens_hsa030203.36916643
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19199275
6Base excision repair_Homo sapiens_hsa034102.89436360
7Ribosome_Homo sapiens_hsa030102.87654847
8Spliceosome_Homo sapiens_hsa030402.84176153
9Homologous recombination_Homo sapiens_hsa034402.78084600
10Nucleotide excision repair_Homo sapiens_hsa034202.65862725
11Pyrimidine metabolism_Homo sapiens_hsa002402.53618035
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43959288
13RNA transport_Homo sapiens_hsa030132.38461879
14Non-homologous end-joining_Homo sapiens_hsa034502.34738444
15Fanconi anemia pathway_Homo sapiens_hsa034602.22677150
16Cell cycle_Homo sapiens_hsa041102.16300885
17Basal transcription factors_Homo sapiens_hsa030222.03334482
18Oxidative phosphorylation_Homo sapiens_hsa001901.97273702
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.93667004
20Parkinsons disease_Homo sapiens_hsa050121.89026092
21RNA degradation_Homo sapiens_hsa030181.88363829
22Purine metabolism_Homo sapiens_hsa002301.85954343
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77727111
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75634293
25Huntingtons disease_Homo sapiens_hsa050161.72924143
26Fatty acid elongation_Homo sapiens_hsa000621.53035135
27Protein export_Homo sapiens_hsa030601.48619478
28mRNA surveillance pathway_Homo sapiens_hsa030151.43825270
29One carbon pool by folate_Homo sapiens_hsa006701.40216148
30Nicotine addiction_Homo sapiens_hsa050331.36294310
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23403005
32Glutathione metabolism_Homo sapiens_hsa004801.23326578
33Steroid biosynthesis_Homo sapiens_hsa001001.20776607
34Collecting duct acid secretion_Homo sapiens_hsa049661.20665866
35Synaptic vesicle cycle_Homo sapiens_hsa047211.19523019
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18379268
37Oocyte meiosis_Homo sapiens_hsa041141.09347939
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.08852312
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02226232
40Alzheimers disease_Homo sapiens_hsa050101.00760873
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99170604
42Biosynthesis of amino acids_Homo sapiens_hsa012300.94129297
43Epstein-Barr virus infection_Homo sapiens_hsa051690.93793507
44Vitamin B6 metabolism_Homo sapiens_hsa007500.93215467
45Pyruvate metabolism_Homo sapiens_hsa006200.88689463
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87484252
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.87189641
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83633901
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83448981
50N-Glycan biosynthesis_Homo sapiens_hsa005100.83343498
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83035732
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80068996
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77890703
54Cardiac muscle contraction_Homo sapiens_hsa042600.77229663
55Fructose and mannose metabolism_Homo sapiens_hsa000510.77193572
56Sulfur relay system_Homo sapiens_hsa041220.73894838
57Sulfur metabolism_Homo sapiens_hsa009200.71509909
58Olfactory transduction_Homo sapiens_hsa047400.68374880
59Pentose phosphate pathway_Homo sapiens_hsa000300.68353183
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67302111
61Vibrio cholerae infection_Homo sapiens_hsa051100.64968797
62Carbon metabolism_Homo sapiens_hsa012000.63752868
63Folate biosynthesis_Homo sapiens_hsa007900.61849166
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61536932
65Taste transduction_Homo sapiens_hsa047420.61249269
66Legionellosis_Homo sapiens_hsa051340.59630587
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58274957
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58077561
69Alcoholism_Homo sapiens_hsa050340.57264667
70Systemic lupus erythematosus_Homo sapiens_hsa053220.54853637
71p53 signaling pathway_Homo sapiens_hsa041150.54713769
72Metabolic pathways_Homo sapiens_hsa011000.52034536
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47584486
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47163647
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46696796
76Type I diabetes mellitus_Homo sapiens_hsa049400.46124928
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45191809
78Arginine and proline metabolism_Homo sapiens_hsa003300.43909068
79Circadian entrainment_Homo sapiens_hsa047130.43638000
80Primary immunodeficiency_Homo sapiens_hsa053400.43354860
81Morphine addiction_Homo sapiens_hsa050320.42681273
82Fatty acid metabolism_Homo sapiens_hsa012120.41606692
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.41066253
84Galactose metabolism_Homo sapiens_hsa000520.39740572
85Amphetamine addiction_Homo sapiens_hsa050310.38706281
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38674872
87GABAergic synapse_Homo sapiens_hsa047270.36877486
88Calcium signaling pathway_Homo sapiens_hsa040200.36531622
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35770770
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34973433
91Phototransduction_Homo sapiens_hsa047440.30747659
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30406603
93Antigen processing and presentation_Homo sapiens_hsa046120.29839649
94Peroxisome_Homo sapiens_hsa041460.29089668
95Butanoate metabolism_Homo sapiens_hsa006500.28934992
96Viral carcinogenesis_Homo sapiens_hsa052030.28795569
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.26553649
98Herpes simplex infection_Homo sapiens_hsa051680.25954913
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24412998
100Arginine biosynthesis_Homo sapiens_hsa002200.23805918
101Asthma_Homo sapiens_hsa053100.23726656
102Lysine degradation_Homo sapiens_hsa003100.23312083
103Colorectal cancer_Homo sapiens_hsa052100.21621659
104Arachidonic acid metabolism_Homo sapiens_hsa005900.21360189
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21241898
106Propanoate metabolism_Homo sapiens_hsa006400.20720813
107Long-term potentiation_Homo sapiens_hsa047200.20116986
108Glutamatergic synapse_Homo sapiens_hsa047240.18857968
109Other glycan degradation_Homo sapiens_hsa005110.18688360
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18488721
111Tryptophan metabolism_Homo sapiens_hsa003800.17388689
112Dopaminergic synapse_Homo sapiens_hsa047280.17377278
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16824465
114Fatty acid degradation_Homo sapiens_hsa000710.16531949
115HTLV-I infection_Homo sapiens_hsa051660.16278852
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15830340
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15497353
118Serotonergic synapse_Homo sapiens_hsa047260.15362748
119beta-Alanine metabolism_Homo sapiens_hsa004100.13621959
120Linoleic acid metabolism_Homo sapiens_hsa005910.13226704
121Insulin secretion_Homo sapiens_hsa049110.12982772
122Regulation of autophagy_Homo sapiens_hsa041400.12897999
123Glucagon signaling pathway_Homo sapiens_hsa049220.12741490
124Selenocompound metabolism_Homo sapiens_hsa004500.11016521
125TGF-beta signaling pathway_Homo sapiens_hsa043500.09178611
126Apoptosis_Homo sapiens_hsa042100.09048462
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.08408963
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08353094
129Allograft rejection_Homo sapiens_hsa053300.07439682
130Tyrosine metabolism_Homo sapiens_hsa003500.06262457
131Shigellosis_Homo sapiens_hsa051310.05483448
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.02363166
133Circadian rhythm_Homo sapiens_hsa047100.02206284

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