TTC41P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.99173712
2axonemal dynein complex assembly (GO:0070286)9.85726840
3cilium or flagellum-dependent cell motility (GO:0001539)8.49695214
4pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.68035667
5epithelial cilium movement (GO:0003351)6.03629369
6cilium movement (GO:0003341)5.95869480
7base-excision repair, AP site formation (GO:0006285)5.56823737
8multicellular organism reproduction (GO:0032504)5.41815651
9pyrimidine nucleotide catabolic process (GO:0006244)5.26263051
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.11566069
11microtubule depolymerization (GO:0007019)4.97337695
12regulation of hypersensitivity (GO:0002883)4.73171980
13positive regulation of protein homodimerization activity (GO:0090073)4.51736762
14regulation of cilium movement (GO:0003352)4.46158251
15cellular ketone body metabolic process (GO:0046950)4.33457353
16negative regulation of calcium ion transport into cytosol (GO:0010523)4.31292150
17regulation of retinoic acid receptor signaling pathway (GO:0048385)4.23722662
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.15240025
19pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.11607773
20ketone body metabolic process (GO:1902224)4.11282427
21regulation of acrosome reaction (GO:0060046)4.05932808
22axoneme assembly (GO:0035082)4.02742332
23motile cilium assembly (GO:0044458)3.91584590
24positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.91210568
25regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.84886541
26substrate-independent telencephalic tangential migration (GO:0021826)3.82492143
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.82492143
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.73164807
29microtubule polymerization or depolymerization (GO:0031109)3.66364230
30negative regulation of mast cell activation (GO:0033004)3.60062349
31sperm motility (GO:0030317)3.46815512
32energy coupled proton transport, down electrochemical gradient (GO:0015985)3.46684671
33ATP synthesis coupled proton transport (GO:0015986)3.46684671
34reproduction (GO:0000003)3.45032186
35sperm capacitation (GO:0048240)3.41664070
36neuronal action potential propagation (GO:0019227)3.40877786
37positive regulation of mast cell degranulation (GO:0043306)3.36456077
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.36456077
39iron ion import (GO:0097286)3.36424548
40intraciliary transport (GO:0042073)3.35041407
41protein complex biogenesis (GO:0070271)3.30446288
42dopamine transport (GO:0015872)3.30360130
43negative regulation of heart rate (GO:0010459)3.28096992
44protein-chromophore linkage (GO:0018298)3.26841672
45regulation of microtubule-based movement (GO:0060632)3.26836079
46positive regulation of mast cell activation (GO:0033005)3.20881216
47meiotic cell cycle (GO:0051321)3.15786445
48single fertilization (GO:0007338)3.12789893
49mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07664417
50left/right axis specification (GO:0070986)3.05881981
51protein prenylation (GO:0018342)3.03699630
52prenylation (GO:0097354)3.03699630
53sperm-egg recognition (GO:0035036)3.00047274
54mitochondrial respiratory chain complex assembly (GO:0033108)2.98336069
55cilium assembly (GO:0042384)2.95262519
56aldehyde catabolic process (GO:0046185)2.93871781
57centriole replication (GO:0007099)2.93267974
58DNA deamination (GO:0045006)2.92701888
59preassembly of GPI anchor in ER membrane (GO:0016254)2.91872491
60cilium organization (GO:0044782)2.91714029
61deoxyribose phosphate catabolic process (GO:0046386)2.86031503
62regulation of inflammatory response to antigenic stimulus (GO:0002861)2.85729682
63piRNA metabolic process (GO:0034587)2.80917296
64positive regulation of immunoglobulin mediated immune response (GO:0002891)2.80677015
65positive regulation of B cell mediated immunity (GO:0002714)2.80677015
66signal peptide processing (GO:0006465)2.79529725
67rRNA methylation (GO:0031167)2.76705438
68positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.73951187
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.72961433
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.72961433
71NADH dehydrogenase complex assembly (GO:0010257)2.72961433
72detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.70234268
73ribosomal small subunit assembly (GO:0000028)2.67553971
74rRNA modification (GO:0000154)2.64772495
75positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.62887288
76dentate gyrus development (GO:0021542)2.61520706
77auditory receptor cell stereocilium organization (GO:0060088)2.58988462
78maturation of 5.8S rRNA (GO:0000460)2.55118064
79regulation of Golgi to plasma membrane protein transport (GO:0042996)2.54706325
80regulation of cell maturation (GO:1903429)2.54450586
81regulation of female gonad development (GO:2000194)2.52796883
82peptidyl-arginine omega-N-methylation (GO:0035247)2.52714735
83regulation of mast cell activation (GO:0033003)2.52081147
84electron transport chain (GO:0022900)2.50939960
85fertilization (GO:0009566)2.50823502
86negative regulation of heart contraction (GO:0045822)2.49803748
87protein polyglutamylation (GO:0018095)2.48771835
88determination of left/right symmetry (GO:0007368)2.48082610
89water-soluble vitamin biosynthetic process (GO:0042364)2.47176560
90respiratory electron transport chain (GO:0022904)2.47117548
91regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44503826
92cell-cell recognition (GO:0009988)2.43226547
93hydrogen ion transmembrane transport (GO:1902600)2.41761635
94ATP biosynthetic process (GO:0006754)2.41259860
95monoamine transport (GO:0015844)2.40672868
96response to pheromone (GO:0019236)2.39783339
97negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.39476298
98positive regulation of protein autophosphorylation (GO:0031954)2.38762780
99negative regulation of stress fiber assembly (GO:0051497)2.37466898
100inositol phosphate catabolic process (GO:0071545)2.37337435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.49645651
2VDR_22108803_ChIP-Seq_LS180_Human3.19948202
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18418668
4TAF15_26573619_Chip-Seq_HEK293_Human3.15839270
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.98276462
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56238058
7ER_23166858_ChIP-Seq_MCF-7_Human2.39970077
8ZNF274_21170338_ChIP-Seq_K562_Hela2.35533797
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.33606429
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.27136079
11EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93770199
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89920166
13ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84694874
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80309750
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.80298683
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80145611
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78831686
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78196450
19EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76326003
20POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70935988
21CBP_20019798_ChIP-Seq_JUKART_Human1.67770123
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.67770123
23VDR_23849224_ChIP-Seq_CD4+_Human1.62987256
24EWS_26573619_Chip-Seq_HEK293_Human1.61197251
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56408946
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53301116
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52631722
28AR_21572438_ChIP-Seq_LNCaP_Human1.51786761
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.51117736
30FOXA1_27270436_Chip-Seq_PROSTATE_Human1.51117736
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49635724
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48813746
33AR_20517297_ChIP-Seq_VCAP_Human1.47326967
34TP53_22573176_ChIP-Seq_HFKS_Human1.45960028
35KLF5_20875108_ChIP-Seq_MESCs_Mouse1.44714489
36ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42830514
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40324730
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.40168072
39CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.40021240
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39151249
41FUS_26573619_Chip-Seq_HEK293_Human1.38563734
42GATA3_21878914_ChIP-Seq_MCF-7_Human1.38051276
43GBX2_23144817_ChIP-Seq_PC3_Human1.36868705
44PRDM14_20953172_ChIP-Seq_ESCs_Human1.36781059
45GATA3_26560356_Chip-Seq_TH2_Human1.35001624
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.33299008
47ERG_20517297_ChIP-Seq_VCAP_Human1.31401304
48RBPJ_21746931_ChIP-Seq_IB4_Human1.30802135
49P300_19829295_ChIP-Seq_ESCs_Human1.30528232
50SMAD4_21799915_ChIP-Seq_A2780_Human1.29785675
51ELK1_19687146_ChIP-ChIP_HELA_Human1.29026125
52NFYB_21822215_ChIP-Seq_K562_Human1.28822372
53STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.26644520
54TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26377696
55NANOG_19829295_ChIP-Seq_ESCs_Human1.26302560
56SOX2_19829295_ChIP-Seq_ESCs_Human1.26302560
57NCOR_22424771_ChIP-Seq_293T_Human1.26152509
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25486563
59BCAT_22108803_ChIP-Seq_LS180_Human1.24470278
60STAT3_23295773_ChIP-Seq_U87_Human1.24243034
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23549419
62NANOG_20526341_ChIP-Seq_ESCs_Human1.22779604
63AR_25329375_ChIP-Seq_VCAP_Human1.21286280
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20806446
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19916447
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19907286
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19544227
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19242002
69TCF4_23295773_ChIP-Seq_U87_Human1.17971156
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.16854769
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16340283
72SMRT_27268052_Chip-Seq_Bcells_Human1.16154138
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.15805154
74HOXB7_26014856_ChIP-Seq_BT474_Human1.15586909
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15329479
76HNFA_21074721_ChIP-Seq_CACO-2_Human1.14309493
77TAF2_19829295_ChIP-Seq_ESCs_Human1.14011797
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13809790
79PHF8_20622853_ChIP-Seq_HELA_Human1.13179189
80TCF4_22108803_ChIP-Seq_LS180_Human1.12959724
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.12612466
82GATA6_21074721_ChIP-Seq_CACO-2_Human1.12390457
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11682282
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10752690
85ERA_21632823_ChIP-Seq_H3396_Human1.10482256
86MYB_26560356_Chip-Seq_TH2_Human1.08034536
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.05593513
88ETV1_20927104_ChIP-Seq_GIST48_Human1.05467481
89FOXP3_21729870_ChIP-Seq_TREG_Human1.04935370
90TBL1_22424771_ChIP-Seq_293T_Human1.03926467
91RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03405557
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.02226783
93FLI1_27457419_Chip-Seq_LIVER_Mouse1.01963768
94TP53_16413492_ChIP-PET_HCT116_Human1.01842833
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01815513
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01586080
97P53_21459846_ChIP-Seq_SAOS-2_Human1.00401923
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99994807
99BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99922479
100P300_18555785_Chip-Seq_ESCs_Mouse0.99752878

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.41272033
2MP0009379_abnormal_foot_pigmentation3.40890821
3MP0002102_abnormal_ear_morphology2.66797638
4MP0003183_abnormal_peptide_metabolism2.63464975
5MP0004147_increased_porphyrin_level2.58305352
6MP0005410_abnormal_fertilization2.56547382
7MP0003718_maternal_effect2.30580130
8MP0002638_abnormal_pupillary_reflex2.26862906
9MP0002653_abnormal_ependyma_morphology2.23381943
10MP0003950_abnormal_plasma_membrane2.22127815
11MP0004043_abnormal_pH_regulation2.17401207
12MP0001986_abnormal_taste_sensitivity2.06710710
13MP0000372_irregular_coat_pigmentation2.06600499
14MP0002163_abnormal_gland_morphology2.03050961
15MP0005253_abnormal_eye_physiology2.02594466
16MP0005671_abnormal_response_to1.99702537
17MP0003646_muscle_fatigue1.95470434
18MP0008872_abnormal_physiological_respon1.91354503
19MP0002822_catalepsy1.89815597
20MP0006292_abnormal_olfactory_placode1.84818526
21MP0009697_abnormal_copulation1.79388635
22MP0002138_abnormal_hepatobiliary_system1.73288860
23MP0008961_abnormal_basal_metabolism1.73012730
24MP0008057_abnormal_DNA_replication1.71464047
25MP0002139_abnormal_hepatobiliary_system1.70414413
26MP0002234_abnormal_pharynx_morphology1.69559732
27MP0004142_abnormal_muscle_tone1.62899779
28MP0008995_early_reproductive_senescence1.62315215
29MP0008875_abnormal_xenobiotic_pharmacok1.60935359
30MP0000685_abnormal_immune_system1.58225074
31MP0005085_abnormal_gallbladder_physiolo1.55756295
32MP0003252_abnormal_bile_duct1.54705688
33MP0005551_abnormal_eye_electrophysiolog1.53950737
34MP0000427_abnormal_hair_cycle1.52979402
35MP0006072_abnormal_retinal_apoptosis1.51579396
36MP0002148_abnormal_hypersensitivity_rea1.50240331
37MP0005408_hypopigmentation1.48506796
38MP0009785_altered_susceptibility_to1.46875877
39MP0002095_abnormal_skin_pigmentation1.45008985
40MP0003890_abnormal_embryonic-extraembry1.44530939
41MP0005645_abnormal_hypothalamus_physiol1.43502844
42MP0001764_abnormal_homeostasis1.37621274
43MP0005084_abnormal_gallbladder_morpholo1.37492923
44MP0001800_abnormal_humoral_immune1.33371284
45MP0009333_abnormal_splenocyte_physiolog1.30964024
46MP0003195_calcinosis1.30431542
47MP0006276_abnormal_autonomic_nervous1.27254289
48MP0005647_abnormal_sex_gland1.26873967
49MP0005379_endocrine/exocrine_gland_phen1.25033786
50MP0003786_premature_aging1.23561036
51MP0001853_heart_inflammation1.23299465
52MP0005387_immune_system_phenotype1.22077370
53MP0001790_abnormal_immune_system1.22077370
54MP0001929_abnormal_gametogenesis1.21423832
55MP0008877_abnormal_DNA_methylation1.14437098
56MP0001905_abnormal_dopamine_level1.12403352
57MP0005000_abnormal_immune_tolerance1.10042866
58MP0002928_abnormal_bile_duct1.09796444
59MP0006036_abnormal_mitochondrial_physio1.07879034
60MP0003186_abnormal_redox_activity1.05693137
61MP0002693_abnormal_pancreas_physiology1.05600062
62MP0002723_abnormal_immune_serum1.04549950
63MP0002452_abnormal_antigen_presenting1.02360848
64MP0001727_abnormal_embryo_implantation0.97938343
65MP0002210_abnormal_sex_determination0.96410615
66MP0004133_heterotaxia0.96008306
67MP0001968_abnormal_touch/_nociception0.94015872
68MP0010094_abnormal_chromosome_stability0.93188926
69MP0003698_abnormal_male_reproductive0.90862856
70MP0002166_altered_tumor_susceptibility0.89980232
71MP0002420_abnormal_adaptive_immunity0.89556444
72MP0005395_other_phenotype0.88559393
73MP0003656_abnormal_erythrocyte_physiolo0.85982654
74MP0001819_abnormal_immune_cell0.85956916
75MP0003806_abnormal_nucleotide_metabolis0.85757744
76MP0001919_abnormal_reproductive_system0.85407419
77MP0004957_abnormal_blastocyst_morpholog0.84830398
78MP0005391_vision/eye_phenotype0.84811491
79MP0009046_muscle_twitch0.83175266
80MP0005310_abnormal_salivary_gland0.82537502
81MP0002736_abnormal_nociception_after0.82086262
82MP0001324_abnormal_eye_pigmentation0.79715712
83MP0010307_abnormal_tumor_latency0.77794344
84MP0003868_abnormal_feces_composition0.77780510
85MP0003191_abnormal_cellular_cholesterol0.76829169
86MP0005389_reproductive_system_phenotype0.75717843
87MP0002132_abnormal_respiratory_system0.75365809
88MP0005075_abnormal_melanosome_morpholog0.75336949
89MP0001661_extended_life_span0.74897846
90MP0005646_abnormal_pituitary_gland0.74153349
91MP0002277_abnormal_respiratory_mucosa0.73289219
92MP0001765_abnormal_ion_homeostasis0.73271198
93MP0009745_abnormal_behavioral_response0.72652292
94MP0005025_abnormal_response_to0.72375287
95MP0008789_abnormal_olfactory_epithelium0.70970730
96MP0005636_abnormal_mineral_homeostasis0.70293944
97MP0002398_abnormal_bone_marrow0.69872227
98MP0010386_abnormal_urinary_bladder0.69711258
99MP0001666_abnormal_nutrient_absorption0.69209706
100MP0000026_abnormal_inner_ear0.68025275

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)8.50379291
2Abnormal respiratory epithelium morphology (HP:0012253)8.50379291
3Absent/shortened dynein arms (HP:0200106)7.23684323
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.23684323
5Abnormal ciliary motility (HP:0012262)7.07238183
6Abnormal respiratory motile cilium physiology (HP:0012261)6.98424637
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.96347927
8Bronchiectasis (HP:0002110)5.82027214
9Rhinitis (HP:0012384)5.44841539
10Chronic sinusitis (HP:0011109)5.25024286
11Infertility (HP:0000789)5.17245311
12Chronic bronchitis (HP:0004469)4.68723260
13Supernumerary spleens (HP:0009799)4.16046403
14Male infertility (HP:0003251)3.87294938
15Nasal polyposis (HP:0100582)3.45834882
163-Methylglutaconic aciduria (HP:0003535)3.38277427
17Bronchitis (HP:0012387)3.12441630
18Azoospermia (HP:0000027)3.01667400
19Pancreatic fibrosis (HP:0100732)2.96534149
20Large eyes (HP:0001090)2.91268616
21Pancreatic cysts (HP:0001737)2.86650318
22Chronic hepatic failure (HP:0100626)2.78482009
23Nephronophthisis (HP:0000090)2.71327304
24Chronic otitis media (HP:0000389)2.69896091
25True hermaphroditism (HP:0010459)2.67890715
26Hypothermia (HP:0002045)2.64091392
27Recurrent sinusitis (HP:0011108)2.54776823
28Abnormality of the nasal mucosa (HP:0000433)2.49018921
29Absent rod-and cone-mediated responses on ERG (HP:0007688)2.43514366
30Increased hepatocellular lipid droplets (HP:0006565)2.30112755
31Lipid accumulation in hepatocytes (HP:0006561)2.30079523
32Abnormality of the renal medulla (HP:0100957)2.25012062
33B lymphocytopenia (HP:0010976)2.22399056
34Increased CSF lactate (HP:0002490)2.20816873
35Recurrent otitis media (HP:0000403)2.16100501
36Abnormality of midbrain morphology (HP:0002418)2.14780759
37Molar tooth sign on MRI (HP:0002419)2.14780759
38Abnormality of the renal cortex (HP:0011035)2.13381803
39Intrahepatic cholestasis (HP:0001406)2.10949793
40Male pseudohermaphroditism (HP:0000037)2.10778802
41Abnormal spermatogenesis (HP:0008669)2.09316601
42Mitochondrial inheritance (HP:0001427)2.08513222
43Congenital, generalized hypertrichosis (HP:0004540)2.08487176
44Renal Fanconi syndrome (HP:0001994)2.05979092
45Recurrent bronchitis (HP:0002837)2.04998009
46Abnormality of B cell number (HP:0010975)2.04563982
47Abnormality of the prostate (HP:0008775)2.03695912
48Squamous cell carcinoma (HP:0002860)2.00458772
49Abnormal rod and cone electroretinograms (HP:0008323)1.99698403
50Acute necrotizing encephalopathy (HP:0006965)1.95431355
51Decreased central vision (HP:0007663)1.95032933
52Bony spicule pigmentary retinopathy (HP:0007737)1.89539859
53Polydipsia (HP:0001959)1.86982607
54Abnormal drinking behavior (HP:0030082)1.86982607
55Constricted visual fields (HP:0001133)1.86463621
56Autoimmune hemolytic anemia (HP:0001890)1.85149698
57Abnormality of macular pigmentation (HP:0008002)1.83379306
58Hypoplasia of the uterus (HP:0000013)1.82259027
59Tubular atrophy (HP:0000092)1.81581536
60Progressive macrocephaly (HP:0004481)1.80727378
61Atelectasis (HP:0100750)1.79649337
62Decreased circulating renin level (HP:0003351)1.78836861
63Median cleft lip (HP:0000161)1.76627857
64Medial flaring of the eyebrow (HP:0010747)1.76319196
65Aplasia/Hypoplasia of the tongue (HP:0010295)1.75777914
66Hypoproteinemia (HP:0003075)1.75132774
67Postaxial foot polydactyly (HP:0001830)1.74315841
68Cutaneous melanoma (HP:0012056)1.73878412
69Glycosuria (HP:0003076)1.71493374
70Abnormality of urine glucose concentration (HP:0011016)1.71493374
71Acute hepatic failure (HP:0006554)1.69747022
72Sensorimotor neuropathy (HP:0007141)1.68765429
73Hepatic necrosis (HP:0002605)1.67793668
74Congenital primary aphakia (HP:0007707)1.66730879
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66240130
76Cystic liver disease (HP:0006706)1.65998529
77IgG deficiency (HP:0004315)1.65609658
78Congenital hepatic fibrosis (HP:0002612)1.65352781
79Arthropathy (HP:0003040)1.64751837
80Hepatocellular necrosis (HP:0001404)1.64546322
81Fair hair (HP:0002286)1.59174689
82Gait imbalance (HP:0002141)1.58683056
83Pendular nystagmus (HP:0012043)1.58447045
84Hypomagnesemia (HP:0002917)1.57887198
85Carpal bone hypoplasia (HP:0001498)1.55498250
86Anencephaly (HP:0002323)1.53881601
87Attenuation of retinal blood vessels (HP:0007843)1.53698380
88Abnormality of alanine metabolism (HP:0010916)1.53138569
89Hyperalaninemia (HP:0003348)1.53138569
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53138569
91Stage 5 chronic kidney disease (HP:0003774)1.51770380
92Acute encephalopathy (HP:0006846)1.51281981
93Aplasia/Hypoplasia of the tibia (HP:0005772)1.50753916
94Increased serum lactate (HP:0002151)1.49770836
95Abolished electroretinogram (ERG) (HP:0000550)1.49695209
96Severe visual impairment (HP:0001141)1.49240124
97Recurrent pneumonia (HP:0006532)1.48970966
98Asplenia (HP:0001746)1.48969182
99Sclerocornea (HP:0000647)1.48843522
100Gaze-evoked nystagmus (HP:0000640)1.48078573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.90836846
2EIF2AK34.82442157
3TLK14.07321328
4BMPR23.81135739
5MAP3K123.40370062
6BRSK22.57242996
7CAMKK22.55439988
8SCYL22.31825744
9CDK122.24904146
10ZAK2.17822868
11PLK42.13001423
12INSRR2.04513182
13TRPM72.00858860
14MAP4K21.94320437
15RIPK41.87189073
16ERBB31.82253024
17TAOK31.71111942
18CDK191.69638183
19TXK1.56636344
20PIK3CG1.41977990
21MAPK151.32202583
22GRK11.31508268
23TEC1.29612321
24BUB11.26788402
25EIF2AK11.26773712
26MYLK1.21899258
27WNK11.16252679
28MST41.15433903
29CCNB11.13892939
30PNCK1.11136301
31TTK1.10955545
32STK391.05209128
33PLK21.02905077
34BTK1.00866652
35BLK0.98852546
36ADRBK20.97024192
37STK160.95372462
38WNK40.95204495
39WEE10.95128214
40MARK30.92539197
41KSR20.90539297
42PTK2B0.88354871
43MUSK0.86986312
44OXSR10.86466662
45NEK20.84272334
46NTRK30.78865810
47MAP3K20.76674334
48ITK0.74241130
49DAPK20.73879398
50TESK20.73463748
51SIK30.73186801
52PLK30.72230044
53EIF2AK20.70247556
54SYK0.67364175
55ATR0.66833284
56STK30.66229682
57WNK30.65712215
58CDK80.65675529
59JAK10.64738522
60CAMK40.64709547
61PLK10.63071625
62PRKAA10.62244854
63STK38L0.61722516
64NME10.61717462
65NEK60.61466642
66SIK10.57056667
67VRK10.56358181
68KSR10.53158719
69BRSK10.52787014
70AURKB0.52668030
71CDC70.51929686
72PRKAA20.51823627
73CAMK10.51222193
74PKN10.49756475
75CHEK20.49193032
76MAP3K40.47726218
77AURKA0.47697215
78LMTK20.45855023
79LYN0.45567088
80CSF1R0.43065092
81ERBB20.42575059
82IKBKB0.40548745
83MAP3K50.40163144
84STK40.39385689
85ROCK10.38929322
86SIK20.37897777
87PAK40.36822987
88PINK10.36796432
89CAMKK10.36507018
90CDK70.33735135
91CHUK0.33548099
92CAMK2A0.32260659
93MAPK130.31718829
94MAP4K10.31255249
95PIM10.31213432
96PRKCI0.29834963
97BMPR1B0.29085832
98RAF10.28384067
99OBSCN0.28046304
100NEK90.27857164

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.94227058
2Oxidative phosphorylation_Homo sapiens_hsa001903.26273508
3Graft-versus-host disease_Homo sapiens_hsa053322.86203300
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.84809009
5Type I diabetes mellitus_Homo sapiens_hsa049402.78069610
6Allograft rejection_Homo sapiens_hsa053302.69195869
7Autoimmune thyroid disease_Homo sapiens_hsa053202.63368460
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54963126
9Homologous recombination_Homo sapiens_hsa034402.54730512
10Parkinsons disease_Homo sapiens_hsa050122.44199873
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.30521892
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.23767052
13Huntingtons disease_Homo sapiens_hsa050162.05579921
14Basal transcription factors_Homo sapiens_hsa030221.99885221
15RNA polymerase_Homo sapiens_hsa030201.98413237
16Protein export_Homo sapiens_hsa030601.97734200
17Proteasome_Homo sapiens_hsa030501.76555718
18Ribosome_Homo sapiens_hsa030101.76429972
19Olfactory transduction_Homo sapiens_hsa047401.75034539
20Linoleic acid metabolism_Homo sapiens_hsa005911.74911072
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67569550
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.65549497
23Alzheimers disease_Homo sapiens_hsa050101.59978580
24Collecting duct acid secretion_Homo sapiens_hsa049661.50755345
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49076146
26Caffeine metabolism_Homo sapiens_hsa002321.47699637
27Antigen processing and presentation_Homo sapiens_hsa046121.47697374
28Rheumatoid arthritis_Homo sapiens_hsa053231.36859396
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.31463736
30Primary immunodeficiency_Homo sapiens_hsa053401.27691030
31Cardiac muscle contraction_Homo sapiens_hsa042601.26258680
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24607818
33ABC transporters_Homo sapiens_hsa020101.19903584
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19286161
35Systemic lupus erythematosus_Homo sapiens_hsa053221.17383954
36RNA degradation_Homo sapiens_hsa030181.16341354
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13064611
38Butanoate metabolism_Homo sapiens_hsa006501.12049992
39Staphylococcus aureus infection_Homo sapiens_hsa051501.08202420
40Phototransduction_Homo sapiens_hsa047441.06033242
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05438505
42Fanconi anemia pathway_Homo sapiens_hsa034601.03673515
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02046480
44Nucleotide excision repair_Homo sapiens_hsa034201.01524293
45Nicotine addiction_Homo sapiens_hsa050330.99546663
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.95634149
47Retinol metabolism_Homo sapiens_hsa008300.95389737
48Ovarian steroidogenesis_Homo sapiens_hsa049130.94530333
49Fatty acid biosynthesis_Homo sapiens_hsa000610.94195699
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90940902
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86114883
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82887536
53Hematopoietic cell lineage_Homo sapiens_hsa046400.82479927
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79080517
55One carbon pool by folate_Homo sapiens_hsa006700.78157928
56Viral myocarditis_Homo sapiens_hsa054160.77764958
57Chemical carcinogenesis_Homo sapiens_hsa052040.76944309
58Peroxisome_Homo sapiens_hsa041460.76469363
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75418124
60Nitrogen metabolism_Homo sapiens_hsa009100.74112417
61NF-kappa B signaling pathway_Homo sapiens_hsa040640.68451373
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68263620
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64178730
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63539321
65Herpes simplex infection_Homo sapiens_hsa051680.56926546
66Tryptophan metabolism_Homo sapiens_hsa003800.56220725
67Arachidonic acid metabolism_Homo sapiens_hsa005900.55381574
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53394865
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53175416
70Oocyte meiosis_Homo sapiens_hsa041140.52955143
71Tuberculosis_Homo sapiens_hsa051520.51627764
72Cell cycle_Homo sapiens_hsa041100.50735039
73Ether lipid metabolism_Homo sapiens_hsa005650.50481234
74Glutamatergic synapse_Homo sapiens_hsa047240.49366350
75Pyrimidine metabolism_Homo sapiens_hsa002400.46253788
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45375112
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43420928
78Metabolic pathways_Homo sapiens_hsa011000.42330573
79Serotonergic synapse_Homo sapiens_hsa047260.42217688
80Alcoholism_Homo sapiens_hsa050340.38177555
81Selenocompound metabolism_Homo sapiens_hsa004500.37578251
82Regulation of autophagy_Homo sapiens_hsa041400.36810339
83Tyrosine metabolism_Homo sapiens_hsa003500.36720314
84Purine metabolism_Homo sapiens_hsa002300.35398618
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.34344808
86Phagosome_Homo sapiens_hsa041450.34238478
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34129156
88Histidine metabolism_Homo sapiens_hsa003400.33123154
89beta-Alanine metabolism_Homo sapiens_hsa004100.32635642
90Starch and sucrose metabolism_Homo sapiens_hsa005000.31745074
91Taste transduction_Homo sapiens_hsa047420.30073106
92Influenza A_Homo sapiens_hsa051640.29851905
93T cell receptor signaling pathway_Homo sapiens_hsa046600.25210482
94Measles_Homo sapiens_hsa051620.24663118
95RNA transport_Homo sapiens_hsa030130.24330158
96Glycerolipid metabolism_Homo sapiens_hsa005610.22626018
97Mismatch repair_Homo sapiens_hsa034300.22562620
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21994715
99Dorso-ventral axis formation_Homo sapiens_hsa043200.20670843
100Epstein-Barr virus infection_Homo sapiens_hsa051690.20585935

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