TTC4P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to zinc ion (GO:0071294)9.37007264
2muscle cell cellular homeostasis (GO:0046716)8.50343945
3cellular response to cadmium ion (GO:0071276)7.27352633
4arginine catabolic process (GO:0006527)5.68802157
5regulation of skeletal muscle contraction (GO:0014819)5.67462666
6regulation of integrin-mediated signaling pathway (GO:2001044)5.62375073
7negative regulation of nitric-oxide synthase activity (GO:0051001)5.59331638
8muscle organ morphogenesis (GO:0048644)5.42479261
9positive regulation of natural killer cell differentiation (GO:0032825)5.06574074
10heart contraction (GO:0060047)5.06552696
11heart process (GO:0003015)5.06552696
12mesenchymal-epithelial cell signaling (GO:0060638)4.93617426
13actin-myosin filament sliding (GO:0033275)4.88803767
14muscle filament sliding (GO:0030049)4.88803767
15regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.70251705
16Rac protein signal transduction (GO:0016601)4.66563721
17response to gravity (GO:0009629)4.65746526
18fibroblast migration (GO:0010761)4.56809693
19actin-mediated cell contraction (GO:0070252)4.51921717
20striated muscle atrophy (GO:0014891)4.50193646
21multicellular organismal movement (GO:0050879)4.38026677
22musculoskeletal movement (GO:0050881)4.38026677
23behavioral response to ethanol (GO:0048149)4.25795978
24response to redox state (GO:0051775)4.24603797
25skeletal muscle adaptation (GO:0043501)4.21814547
26skeletal muscle contraction (GO:0003009)4.11815355
27regulation of chronic inflammatory response (GO:0002676)4.06207015
28regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.97834433
29skeletal muscle tissue development (GO:0007519)3.92892157
30regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.91770711
31response to muscle activity (GO:0014850)3.90998361
32positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.87741554
33neuromuscular junction development (GO:0007528)3.86678409
34muscle atrophy (GO:0014889)3.84741637
35membrane raft organization (GO:0031579)3.83046986
36barbed-end actin filament capping (GO:0051016)3.79752148
37cardiac myofibril assembly (GO:0055003)3.52484056
38positive regulation of actin filament depolymerization (GO:0030836)3.46928371
39positive regulation of tolerance induction (GO:0002645)3.39633816
40myofibril assembly (GO:0030239)3.39523014
41arginine metabolic process (GO:0006525)3.37110923
42vagina development (GO:0060068)3.33561103
43negative regulation of monooxygenase activity (GO:0032769)3.32320501
44nucleotide-sugar biosynthetic process (GO:0009226)3.31386566
45actin filament-based movement (GO:0030048)3.31080868
46skin morphogenesis (GO:0043589)3.30619529
47negative regulation of nitric oxide biosynthetic process (GO:0045019)3.29892842
48regulation of the force of heart contraction (GO:0002026)3.26909976
49actin filament depolymerization (GO:0030042)3.24550608
50regulation of natural killer cell differentiation (GO:0032823)3.24524978
51peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.24155450
52membrane assembly (GO:0071709)3.23686405
53sarcomere organization (GO:0045214)3.20887056
54substrate adhesion-dependent cell spreading (GO:0034446)3.20591557
55response to cadmium ion (GO:0046686)3.19818604
56response to zinc ion (GO:0010043)3.17839421
57regulation of apoptotic process involved in morphogenesis (GO:1902337)3.12828883
584-hydroxyproline metabolic process (GO:0019471)3.12609888
59cellular response to interferon-alpha (GO:0035457)3.12590142
60positive regulation of sodium ion transmembrane transport (GO:1902307)3.12221097
61regulation of muscle hypertrophy (GO:0014743)3.12093044
62zinc ion homeostasis (GO:0055069)3.08556146
63COPII vesicle coating (GO:0048208)3.08078241
64collagen fibril organization (GO:0030199)3.02743184
65regulation of metalloenzyme activity (GO:0048552)3.01092764
66regulation of sarcomere organization (GO:0060297)2.98848431
67positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.98089494
68negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.93119247
69muscle tissue morphogenesis (GO:0060415)2.90071360
70muscle organ development (GO:0007517)2.87624261
71negative regulation of muscle hypertrophy (GO:0014741)2.87080762
72regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.84969021
73protein hydroxylation (GO:0018126)2.84707974
74localization within membrane (GO:0051668)2.82513227
75embryonic cranial skeleton morphogenesis (GO:0048701)2.81051676
76muscle structure development (GO:0061061)2.80838865
77branching involved in labyrinthine layer morphogenesis (GO:0060670)2.80296329
78striated muscle tissue development (GO:0014706)2.77759487
79positive regulation of vasculogenesis (GO:2001214)2.77551874
80regulation of prostaglandin secretion (GO:0032306)2.75256893
81myoblast fusion (GO:0007520)2.75216225
82muscle cell fate commitment (GO:0042693)2.75177574
83skeletal muscle tissue regeneration (GO:0043403)2.74660235
84response to inactivity (GO:0014854)2.73907850
85embryonic viscerocranium morphogenesis (GO:0048703)2.73653485
86cardiac muscle tissue morphogenesis (GO:0055008)2.73636443
87negative regulation of fatty acid transport (GO:2000192)2.73382091
88negative regulation of mast cell activation (GO:0033004)2.68872372
89positive regulation of myoblast differentiation (GO:0045663)2.68816932
90Golgi to plasma membrane protein transport (GO:0043001)2.68713872
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.68521739
92negative regulation of lipase activity (GO:0060192)2.67500455
93neuromuscular synaptic transmission (GO:0007274)2.65089050
94positive regulation of positive chemotaxis (GO:0050927)2.64574480
95cullin deneddylation (GO:0010388)2.64202524
96peptidyl-proline hydroxylation (GO:0019511)2.63955078
97natural killer cell differentiation (GO:0001779)2.62132979
98regulation of dendritic spine development (GO:0060998)2.60882025
99multicellular organism reproduction (GO:0032504)2.60578695
100keratinocyte proliferation (GO:0043616)2.59276944

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.67849384
2SMAD_19615063_ChIP-ChIP_OVARY_Human5.38549519
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.04321260
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.03071809
5HIF1A_21447827_ChIP-Seq_MCF-7_Human3.00066415
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82542783
7CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.75107067
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73213964
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52096864
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.46740038
11BRD4_25478319_ChIP-Seq_HGPS_Human2.44392137
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42554813
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.40934117
14EZH2_27294783_Chip-Seq_NPCs_Mouse2.37147736
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.28701247
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.24129045
17MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.20974924
18CJUN_26792858_Chip-Seq_BT549_Human2.20526786
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.16096063
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.14783261
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06856400
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.99539812
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94214007
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.93918785
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.90630785
26CRX_20693478_ChIP-Seq_RETINA_Mouse1.86678166
27ZNF274_21170338_ChIP-Seq_K562_Hela1.86156875
28PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.85757573
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85657150
30SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.82067540
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.77289961
32TP53_16413492_ChIP-PET_HCT116_Human1.75379327
33CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.70016787
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67985325
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67985325
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62282135
37TP53_18474530_ChIP-ChIP_U2OS_Human1.59927313
38OCT4_21477851_ChIP-Seq_ESCs_Mouse1.58396676
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56661330
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.55851613
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.54012448
42GBX2_23144817_ChIP-Seq_PC3_Human1.53662791
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.51624799
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51492149
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48791719
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47414582
47ER_23166858_ChIP-Seq_MCF-7_Human1.46144669
48P300_19829295_ChIP-Seq_ESCs_Human1.45563009
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44354339
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42250201
51NANOG_19829295_ChIP-Seq_ESCs_Human1.36079490
52SOX2_19829295_ChIP-Seq_ESCs_Human1.36079490
53BCAT_22108803_ChIP-Seq_LS180_Human1.35455572
54HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34611810
55PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31623163
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31134664
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29696447
58CDX2_22108803_ChIP-Seq_LS180_Human1.25306443
59TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24370025
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23250059
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.22333180
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.22141290
63AR_21572438_ChIP-Seq_LNCaP_Human1.20607254
64SMAD4_21799915_ChIP-Seq_A2780_Human1.19494651
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.19160051
66STAT3_23295773_ChIP-Seq_U87_Human1.16363831
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15574714
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09868071
69ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07960590
70SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.06037147
71VDR_22108803_ChIP-Seq_LS180_Human1.04837337
72PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04710066
73P53_22387025_ChIP-Seq_ESCs_Mouse1.03438692
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02752363
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.02662350
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.02071969
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01970303
78EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01247197
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97548373
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96801264
81VDR_24787735_ChIP-Seq_THP-1_Human0.96445173
82ELK1_19687146_ChIP-ChIP_HELA_Human0.95413053
83FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94056684
84TP63_23658742_ChIP-Seq_EP156T_Human0.93911121
85CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93621737
86SALL4_22934838_ChIP-ChIP_CD34+_Human0.93576007
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.92360597
88FLI1_21867929_ChIP-Seq_TH2_Mouse0.92085799
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91963533
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91963533
91GABP_17652178_ChIP-ChIP_JURKAT_Human0.89063893
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88198238
93TBX20_22080862_ChIP-Seq_HEART_Mouse0.87399532
94TBX20_22328084_ChIP-Seq_HEART_Mouse0.87399532
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84920877
96PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84560034
97PU1_27457419_Chip-Seq_LIVER_Mouse0.84249956
98FUS_26573619_Chip-Seq_HEK293_Human0.83846801
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83424000
100TBL1_22424771_ChIP-Seq_293T_Human0.83375404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane8.67331322
2MP0004145_abnormal_muscle_electrophysio6.78443019
3MP0008438_abnormal_cutaneous_collagen4.68100882
4MP0003011_delayed_dark_adaptation4.62723996
5MP0000749_muscle_degeneration4.15883743
6MP0004270_analgesia3.69372134
7MP0000372_irregular_coat_pigmentation3.44572468
8MP0000747_muscle_weakness2.92351797
9MP0004233_abnormal_muscle_weight2.69406266
10MP0001299_abnormal_eye_distance/2.64000624
11MP0005275_abnormal_skin_tensile2.43116748
12MP0004084_abnormal_cardiac_muscle2.34346309
13MP0003279_aneurysm2.12162344
14MP0001661_extended_life_span2.06967331
15MP0000759_abnormal_skeletal_muscle2.03420037
16MP0005623_abnormal_meninges_morphology1.82658307
17MP0004272_abnormal_basement_membrane1.75249755
18MP0000750_abnormal_muscle_regeneration1.72748418
19MP0000751_myopathy1.71338950
20MP0010030_abnormal_orbit_morphology1.70502790
21MP0009780_abnormal_chondrocyte_physiolo1.66819795
22MP0004036_abnormal_muscle_relaxation1.66816881
23MP0002933_joint_inflammation1.61549882
24MP0005360_urolithiasis1.59771432
25MP0002269_muscular_atrophy1.55467998
26MP0002106_abnormal_muscle_physiology1.54550371
27MP0001879_abnormal_lymphatic_vessel1.39902891
28MP0003828_pulmonary_edema1.39191262
29MP0003705_abnormal_hypodermis_morpholog1.38521811
30MP0002295_abnormal_pulmonary_circulatio1.36019746
31MP0003646_muscle_fatigue1.35979723
32MP0003045_fibrosis1.35178123
33MP0004087_abnormal_muscle_fiber1.33689846
34MP0003436_decreased_susceptibility_to1.30486233
35MP0005369_muscle_phenotype1.29164987
36MP0002837_dystrophic_cardiac_calcinosis1.25318877
37MP0009384_cardiac_valve_regurgitation1.25276369
38MP0005023_abnormal_wound_healing1.20830173
39MP0003186_abnormal_redox_activity1.20363958
40MP0005620_abnormal_muscle_contractility1.18066710
41MP0000733_abnormal_muscle_development1.17038900
42MP0000685_abnormal_immune_system1.14068580
43MP0002108_abnormal_muscle_morphology1.13031752
44MP0004215_abnormal_myocardial_fiber1.12765229
45MP0003091_abnormal_cell_migration1.02354133
46MP0009250_abnormal_appendicular_skeleto1.01222689
47MP0005367_renal/urinary_system_phenotyp0.99587740
48MP0000516_abnormal_urinary_system0.99587740
49MP0000569_abnormal_digit_pigmentation0.98872373
50MP0005595_abnormal_vascular_smooth0.96524105
51MP0002972_abnormal_cardiac_muscle0.92432505
52MP0001958_emphysema0.91521536
53MP0000538_abnormal_urinary_bladder0.91023286
54MP0002166_altered_tumor_susceptibility0.91001455
55MP0002168_other_aberrant_phenotype0.90735876
56MP0010368_abnormal_lymphatic_system0.89635075
57MP0002332_abnormal_exercise_endurance0.87845078
58MP0000013_abnormal_adipose_tissue0.84875684
59MP0006054_spinal_hemorrhage0.83870025
60MP0002006_tumorigenesis0.83263596
61MP0005330_cardiomyopathy0.78990266
62MP0005503_abnormal_tendon_morphology0.77672465
63MP0004484_altered_response_of0.75429344
64MP0000767_abnormal_smooth_muscle0.73754558
65MP0000003_abnormal_adipose_tissue0.70829458
66MP0001542_abnormal_bone_strength0.70533216
67MP0002734_abnormal_mechanical_nocicepti0.69506526
68MP0005164_abnormal_response_to0.69207275
69MP0009697_abnormal_copulation0.69148065
70MP0008775_abnormal_heart_ventricle0.66779672
71MP0001533_abnormal_skeleton_physiology0.66757550
72MP0000163_abnormal_cartilage_morphology0.64870811
73MP0004883_abnormal_blood_vessel0.61673182
74MP0000230_abnormal_systemic_arterial0.61228286
75MP0002234_abnormal_pharynx_morphology0.61200980
76MP0003566_abnormal_cell_adhesion0.60386034
77MP0005395_other_phenotype0.59546332
78MP0005390_skeleton_phenotype0.58932998
79MP0003221_abnormal_cardiomyocyte_apopto0.57911584
80MP0005508_abnormal_skeleton_morphology0.57496221
81MP0002876_abnormal_thyroid_physiology0.55301832
82MP0001348_abnormal_lacrimal_gland0.55098877
83MP0005253_abnormal_eye_physiology0.54268250
84MP0001881_abnormal_mammary_gland0.51875964
85MP0002060_abnormal_skin_morphology0.51480788
86MP0003959_abnormal_lean_body0.51454492
87MP0010234_abnormal_vibrissa_follicle0.50653669
88MP0005375_adipose_tissue_phenotype0.50240882
89MP0002114_abnormal_axial_skeleton0.49599372
90MP0001986_abnormal_taste_sensitivity0.48528485
91MP0001764_abnormal_homeostasis0.48126538
92MP0008260_abnormal_autophagy0.47947909
93MP0001544_abnormal_cardiovascular_syste0.47638782
94MP0005385_cardiovascular_system_phenoty0.47638782
95MP0010352_gastrointestinal_tract_polyps0.47413290
96MP0005171_absent_coat_pigmentation0.47397774
97MP0005451_abnormal_body_composition0.44547781
98MP0003137_abnormal_impulse_conducting0.43282061
99MP0005084_abnormal_gallbladder_morpholo0.43280643
100MP0001501_abnormal_sleep_pattern0.42529618

Predicted human phenotypes

RankGene SetZ-score
1Fatigable weakness (HP:0003473)8.28692345
2Abnormality of the neuromuscular junction (HP:0003398)8.28692345
3Popliteal pterygium (HP:0009756)7.86456495
4Weak cry (HP:0001612)7.23980165
5Amniotic constriction ring (HP:0009775)6.82475379
6Abnormality of placental membranes (HP:0011409)6.82475379
7Easy fatigability (HP:0003388)5.85706263
8Fetal akinesia sequence (HP:0001989)5.58811487
9Nemaline bodies (HP:0003798)5.43079935
10Gowers sign (HP:0003391)5.38990028
11Mesomelia (HP:0003027)4.78400700
12Nonprogressive disorder (HP:0003680)4.73496720
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.71223152
14Aplasia of the musculature (HP:0100854)4.69616731
15Muscle fiber inclusion bodies (HP:0100299)4.54159388
16Hypoplastic ischia (HP:0003175)4.48413897
17Long clavicles (HP:0000890)4.32489700
18Bell-shaped thorax (HP:0001591)4.28511924
19Wrist flexion contracture (HP:0001239)4.18480887
20Fibular aplasia (HP:0002990)4.17648836
21Microglossia (HP:0000171)4.09887917
22Decreased muscle mass (HP:0003199)3.99784754
23Abnormality of the ischium (HP:0003174)3.79797878
24Malignant hyperthermia (HP:0002047)3.72600905
25Pterygium (HP:0001059)3.71324942
26Absent phalangeal crease (HP:0006109)3.67420690
27Akinesia (HP:0002304)3.49740611
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.32665004
29Respiratory insufficiency due to muscle weakness (HP:0002747)3.27839578
30Abnormal finger flexion creases (HP:0006143)2.99769865
31Aplasia/Hypoplasia involving the musculature (HP:0001460)2.96294621
32Delayed gross motor development (HP:0002194)2.95176204
33Dyschromatopsia (HP:0007641)2.89262146
34Exercise-induced muscle cramps (HP:0003710)2.68940113
35Type 1 muscle fiber predominance (HP:0003803)2.59494931
36Calf muscle hypertrophy (HP:0008981)2.56195531
37Thin ribs (HP:0000883)2.53545704
38Muscle hypertrophy of the lower extremities (HP:0008968)2.51521322
39Cutaneous melanoma (HP:0012056)2.50231994
40Cystic hygroma (HP:0000476)2.48287037
41Arthrogryposis multiplex congenita (HP:0002804)2.47516998
42Exercise-induced myalgia (HP:0003738)2.37778153
43Short palpebral fissure (HP:0012745)2.24568726
44Bulbar palsy (HP:0001283)2.18561149
45Rhabdomyolysis (HP:0003201)2.17534416
46Abnormality of the calf musculature (HP:0001430)2.09390505
47Abnormalities of placenta or umbilical cord (HP:0001194)2.03249292
48Type 2 muscle fiber atrophy (HP:0003554)11.1787864
49Muscle fiber atrophy (HP:0100295)10.0270001
50Entropion (HP:0000621)1.98174241
51Hypoplastic iliac wings (HP:0002866)1.97231826
52Aortic dissection (HP:0002647)1.96470398
53Metaphyseal dysplasia (HP:0100255)1.94247629
54Depressed nasal tip (HP:0000437)1.93878196
55Neck muscle weakness (HP:0000467)1.91510427
56Subaortic stenosis (HP:0001682)1.89085401
57Abnormality of the left ventricular outflow tract (HP:0011103)1.89085401
58Abnormality of the pubic bones (HP:0003172)1.87515422
59Generalized muscle weakness (HP:0003324)1.84330678
60Round ear (HP:0100830)1.83027649
61Hyporeflexia of lower limbs (HP:0002600)1.77373327
62Poor suck (HP:0002033)1.75861482
63Myoglobinuria (HP:0002913)1.75466250
64Hypoplastic heart (HP:0001961)1.73338628
65Rhizomelia (HP:0008905)1.72339996
66Diminished movement (HP:0002374)1.71151338
67Spondylolisthesis (HP:0003302)1.70627008
68Abnormality of the wing of the ilium (HP:0011867)1.64845852
69Ovoid vertebral bodies (HP:0003300)1.63341229
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.61488115
71Muscle stiffness (HP:0003552)1.60648054
72Ulnar deviation of the wrist (HP:0003049)1.57649973
73Reduced subcutaneous adipose tissue (HP:0003758)1.53802863
74Distal arthrogryposis (HP:0005684)1.53766132
75Lipoatrophy (HP:0100578)1.53239670
76Hypoplastic scapulae (HP:0000882)1.52507184
77Aplasia/Hypoplasia of the scapulae (HP:0006713)1.52507184
78Abnormality of the alveolar ridges (HP:0006477)1.51724776
79Hematochezia (HP:0002573)1.51083059
80Aplasia/Hypoplasia of the fibula (HP:0006492)1.49781808
81Hypoplasia of the iris (HP:0007676)1.48138451
82Asymmetry of the thorax (HP:0001555)1.43068532
83Fatigue (HP:0012378)1.42790536
84Cervical subluxation (HP:0003308)1.40805448
85Recurrent corneal erosions (HP:0000495)1.40091634
86Bone cyst (HP:0012062)1.39257454
87Dislocated radial head (HP:0003083)1.38618070
88Webbed neck (HP:0000465)1.38216994
89Vascular tortuosity (HP:0004948)1.36465439
90Sudden death (HP:0001699)1.36002239
91Aortic aneurysm (HP:0004942)1.35573253
92Soft skin (HP:0000977)1.34153402
93Progressive macrocephaly (HP:0004481)1.33594258
94Arterial tortuosity (HP:0005116)1.32927209
95Poikiloderma (HP:0001029)1.32637391
96Abnormality of the intrinsic pathway (HP:0010989)1.32387631
97Abnormality of the radial head (HP:0003995)1.32379029
98Premature rupture of membranes (HP:0001788)1.31773402
99Increased corneal curvature (HP:0100692)1.31562479
100Keratoconus (HP:0000563)1.31562479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK243.59074190
2MAP4K23.34550709
3MAP3K122.75701328
4FRK2.44505353
5LIMK12.35955365
6MUSK14.5363293
7OBSCN1.61475593
8ILK1.61021242
9DDR21.60825776
10MAPKAPK31.37759377
11MYLK1.08088639
12TRPM71.04526277
13CCNB10.99658805
14EIF2AK30.96362001
15PLK20.93566537
16MELK0.82527962
17FGFR20.79365031
18NLK0.75168335
19CLK10.74685119
20TYK20.72565086
21PIK3CG0.70264262
22EIF2AK10.68468943
23NUAK10.67103355
24FER0.63331670
25SGK30.58397661
26JAK10.53792134
27CDK80.52349737
28STK390.52274502
29PRKD30.51573471
30PAK30.51044127
31PHKG20.50408668
32PHKG10.50408668
33MAPK120.50039845
34MAP3K50.49199249
35BCKDK0.49127431
36VRK20.48335896
37CAMK1D0.46971949
38CAMKK20.46732168
39ROCK10.45510840
40MAPK130.44579896
41TAOK30.44035331
42OXSR10.43374166
43FGFR30.42197714
44FGFR10.40605257
45PAK20.40354136
46PIK3CA0.39748563
47PRKCQ0.39725994
48SGK20.39616314
49PLK30.39162655
50TESK10.35475031
51STK30.35416843
52SIK30.34881186
53MARK30.32929299
54NEK90.32480163
55EEF2K0.32446257
56CSNK1A1L0.32223771
57IRAK30.30791980
58CAMK1G0.30348728
59TRIM280.29445510
60DAPK10.27835001
61DMPK0.27072370
62CAMK2D0.26820121
63MAPK110.25070413
64TGFBR20.24881918
65GRK10.24715607
66MAP3K90.24622658
67ROCK20.24102397
68IKBKB0.23622601
69AKT20.23495194
70MAP3K100.22761452
71PINK10.22448650
72ABL10.22438195
73INSRR0.22431880
74STK40.22064346
75DAPK30.21723206
76NEK10.21364057
77INSR0.21247044
78LATS10.20984372
79TAF10.20886484
80ERBB30.20423718
81MAP3K30.20322979
82PAK40.20059993
83AKT30.19430973
84MOS0.18827874
85BMPR1B0.18679579
86ADRBK20.18589172
87PIM10.17865224
88CAMK10.17490107
89CSNK1G10.15889876
90VRK10.15801064
91CAMK40.14982656
92PRKCE0.14683739
93HCK0.14225638
94BUB10.13705186
95JAK30.12958159
96ZAP700.12789741
97PRKG10.12125489
98MAPKAPK50.10404526
99CSNK1G20.10055013
100ADRBK10.09921956

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049784.31253712
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.53219196
3Circadian rhythm_Homo sapiens_hsa047103.49976765
4Sulfur metabolism_Homo sapiens_hsa009203.43734147
5SNARE interactions in vesicular transport_Homo sapiens_hsa041303.26700617
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.18947013
7Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007603.18784777
8Selenocompound metabolism_Homo sapiens_hsa004503.09202483
9Proteasome_Homo sapiens_hsa030502.78116818
10Dilated cardiomyopathy_Homo sapiens_hsa054142.28536588
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21386692
12Protein export_Homo sapiens_hsa030602.17836388
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.16155083
14Nitrogen metabolism_Homo sapiens_hsa009102.02154522
15Viral myocarditis_Homo sapiens_hsa054161.93403275
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80380278
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.71908037
18Regulation of autophagy_Homo sapiens_hsa041401.70331370
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70004000
20p53 signaling pathway_Homo sapiens_hsa041151.49928120
21Asthma_Homo sapiens_hsa053101.35224318
22ECM-receptor interaction_Homo sapiens_hsa045121.29121004
23Arginine and proline metabolism_Homo sapiens_hsa003301.27297994
24Arginine biosynthesis_Homo sapiens_hsa002201.26472089
25Cardiac muscle contraction_Homo sapiens_hsa042601.15041793
26Focal adhesion_Homo sapiens_hsa045101.11322745
27Hedgehog signaling pathway_Homo sapiens_hsa043401.09131659
28Proteoglycans in cancer_Homo sapiens_hsa052051.04957956
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03926822
30TGF-beta signaling pathway_Homo sapiens_hsa043501.03910044
31Starch and sucrose metabolism_Homo sapiens_hsa005001.00284436
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99298530
33Propanoate metabolism_Homo sapiens_hsa006400.99015154
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98718427
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93731016
36Galactose metabolism_Homo sapiens_hsa000520.92527278
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91014597
38Legionellosis_Homo sapiens_hsa051340.89800429
39Fatty acid biosynthesis_Homo sapiens_hsa000610.89678162
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86777786
41Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86701674
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84625935
43Tight junction_Homo sapiens_hsa045300.83629244
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82047831
45PPAR signaling pathway_Homo sapiens_hsa033200.81466980
46Jak-STAT signaling pathway_Homo sapiens_hsa046300.80379956
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77529530
48Complement and coagulation cascades_Homo sapiens_hsa046100.76586464
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75796531
50Dorso-ventral axis formation_Homo sapiens_hsa043200.73724069
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72989926
52Melanoma_Homo sapiens_hsa052180.70770803
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70224427
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69805285
55Insulin resistance_Homo sapiens_hsa049310.69233849
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67555239
57Autoimmune thyroid disease_Homo sapiens_hsa053200.66833306
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64903604
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.64040601
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62901478
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62015687
62RNA degradation_Homo sapiens_hsa030180.61976901
63Allograft rejection_Homo sapiens_hsa053300.61858670
64Adherens junction_Homo sapiens_hsa045200.61855758
65Nucleotide excision repair_Homo sapiens_hsa034200.56471820
66Glutathione metabolism_Homo sapiens_hsa004800.53902090
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52209612
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50835808
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50530502
70Chemical carcinogenesis_Homo sapiens_hsa052040.50422115
71Calcium signaling pathway_Homo sapiens_hsa040200.49110064
72Oxytocin signaling pathway_Homo sapiens_hsa049210.48933744
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47651601
74Fatty acid degradation_Homo sapiens_hsa000710.47156755
75Hematopoietic cell lineage_Homo sapiens_hsa046400.46834560
76Tyrosine metabolism_Homo sapiens_hsa003500.46741723
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.46051034
78Peroxisome_Homo sapiens_hsa041460.43971868
79Alzheimers disease_Homo sapiens_hsa050100.42131464
80Pyruvate metabolism_Homo sapiens_hsa006200.41823074
81Glucagon signaling pathway_Homo sapiens_hsa049220.41237927
82Histidine metabolism_Homo sapiens_hsa003400.39693157
83Sphingolipid metabolism_Homo sapiens_hsa006000.39515444
84Parkinsons disease_Homo sapiens_hsa050120.38716444
85Oxidative phosphorylation_Homo sapiens_hsa001900.38664136
86Caffeine metabolism_Homo sapiens_hsa002320.38539107
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37525673
88Phototransduction_Homo sapiens_hsa047440.37147884
89Basal transcription factors_Homo sapiens_hsa030220.36493975
90Vibrio cholerae infection_Homo sapiens_hsa051100.35788526
91Small cell lung cancer_Homo sapiens_hsa052220.35520576
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.33895330
93Type I diabetes mellitus_Homo sapiens_hsa049400.33731827
94Graft-versus-host disease_Homo sapiens_hsa053320.27879814
95One carbon pool by folate_Homo sapiens_hsa006700.24305174
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.23662351
97Endocytosis_Homo sapiens_hsa041440.21712936
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21382113
99Retinol metabolism_Homo sapiens_hsa008300.21299696
100Huntingtons disease_Homo sapiens_hsa050160.20891228

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