TTC7A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing tetratricopeptide repeats. Mutations in this gene disrupt intestinal development and can cause early onset inflammatory bowel disease and intestinal atresia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.30949961
2modulation by symbiont of host immune response (GO:0052553)4.72636855
3positive regulation by symbiont of host defense response (GO:0052509)4.72636855
4modulation by symbiont of host defense response (GO:0052031)4.72636855
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.72636855
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.72636855
7positive regulation by organism of defense response of other organism involved in symbiotic interact4.72636855
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.69989187
9antigen processing and presentation of endogenous antigen (GO:0019883)4.48897145
10response to peptidoglycan (GO:0032494)4.42810701
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.34291853
12negative regulation of cell killing (GO:0031342)4.34291853
13macrophage activation involved in immune response (GO:0002281)4.32409663
14negative regulation of erythrocyte differentiation (GO:0045647)4.30493833
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.18872409
16regulation of gamma-delta T cell activation (GO:0046643)4.13701749
17detection of other organism (GO:0098543)4.08670412
18response to muramyl dipeptide (GO:0032495)4.03672853
19detection of bacterium (GO:0016045)4.02051836
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95776394
21neutrophil activation involved in immune response (GO:0002283)3.93021361
22regulation of gamma-delta T cell differentiation (GO:0045586)3.89530286
23positive thymic T cell selection (GO:0045059)3.85676364
24cellular extravasation (GO:0045123)3.72211435
25immunoglobulin mediated immune response (GO:0016064)3.67962841
26regulation of interferon-beta biosynthetic process (GO:0045357)3.65860713
27regulation of B cell receptor signaling pathway (GO:0050855)3.59186265
28B cell receptor signaling pathway (GO:0050853)3.57627623
29negative thymic T cell selection (GO:0045060)3.52068797
30regulation of mast cell degranulation (GO:0043304)3.46697851
31regulation of myeloid leukocyte mediated immunity (GO:0002886)3.44902771
32positive regulation of B cell differentiation (GO:0045579)3.40885381
33detection of external biotic stimulus (GO:0098581)3.39508703
34regulation of leukocyte degranulation (GO:0043300)3.38157052
35negative T cell selection (GO:0043383)3.32686807
36regulation of T-helper 2 cell differentiation (GO:0045628)3.30795851
37negative regulation of interleukin-12 production (GO:0032695)3.30298844
38germinal center formation (GO:0002467)3.28386126
39myeloid cell activation involved in immune response (GO:0002275)3.24281972
40NIK/NF-kappaB signaling (GO:0038061)3.23644347
41T cell selection (GO:0045058)3.22014768
42leukocyte aggregation (GO:0070486)3.20742142
43thymic T cell selection (GO:0045061)3.20667169
44mannose metabolic process (GO:0006013)3.20258788
45regulation of mast cell activation involved in immune response (GO:0033006)3.14439251
46response to host immune response (GO:0052572)3.11258724
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.11258724
48pinocytosis (GO:0006907)3.10564971
49positive T cell selection (GO:0043368)3.09617550
50response to host (GO:0075136)3.08654892
51response to host defenses (GO:0052200)3.08654892
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.08654892
53regulation of dendritic cell antigen processing and presentation (GO:0002604)3.08169785
54negative regulation of granulocyte differentiation (GO:0030853)3.06676940
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.04687301
56detection of biotic stimulus (GO:0009595)3.03044851
57regulation of B cell differentiation (GO:0045577)3.02770244
58detection of molecule of bacterial origin (GO:0032490)3.02248920
59negative regulation of lymphocyte mediated immunity (GO:0002707)2.95227790
60macrophage activation (GO:0042116)2.90790307
61negative regulation of leukocyte mediated immunity (GO:0002704)2.87229311
62positive regulation of mast cell activation (GO:0033005)2.86464120
63interferon-gamma-mediated signaling pathway (GO:0060333)2.79584990
64respiratory burst (GO:0045730)2.76328159
65regulation of tolerance induction (GO:0002643)2.75118807
66positive regulation of type 2 immune response (GO:0002830)2.74778303
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.73636515
68tolerance induction (GO:0002507)2.73587462
69regulation of mast cell activation (GO:0033003)2.73288749
70negative regulation of T cell mediated immunity (GO:0002710)2.72964594
71positive regulation of mast cell degranulation (GO:0043306)2.72268260
72positive regulation of mast cell activation involved in immune response (GO:0033008)2.72268260
73B cell mediated immunity (GO:0019724)2.71479765
74response to laminar fluid shear stress (GO:0034616)2.71241408
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71218586
76microglial cell activation (GO:0001774)2.70797704
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.67147670
78regulation of antigen processing and presentation (GO:0002577)2.65981044
79lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65891894
80T cell migration (GO:0072678)2.64495745
81response to type I interferon (GO:0034340)2.63455646
82positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62955935
83cellular response to type I interferon (GO:0071357)2.62570715
84type I interferon signaling pathway (GO:0060337)2.62570715
85regulation of regulated secretory pathway (GO:1903305)2.62338763
86neutrophil activation (GO:0042119)2.61821365
87regulation of granulocyte differentiation (GO:0030852)2.60287349
88regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59753191
89regulation of T cell tolerance induction (GO:0002664)2.58168788
90positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.57477505
91defense response to protozoan (GO:0042832)2.55672276
92positive regulation of antigen processing and presentation (GO:0002579)2.54583238
93antigen processing and presentation via MHC class Ib (GO:0002475)2.54183734
94regulation of type 2 immune response (GO:0002828)2.54016453
95negative regulation of interleukin-6 production (GO:0032715)2.53997945
96histone H3-K36 demethylation (GO:0070544)2.53181999
97positive regulation of granulocyte differentiation (GO:0030854)2.51394343
98positive regulation of Cdc42 GTPase activity (GO:0043089)2.51351592
99positive regulation of interferon-alpha production (GO:0032727)2.51062131
100B cell homeostasis (GO:0001782)2.50448016

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.27364054
2VDR_21846776_ChIP-Seq_THP-1_Human3.37888933
3MYC_22102868_ChIP-Seq_BL_Human3.08951352
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.86197593
5VDR_24763502_ChIP-Seq_THP-1_Human2.78402254
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.72416459
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.67270537
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51365313
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.48191673
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47570274
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45815199
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.43389549
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.39200583
14TCF7_22412390_ChIP-Seq_EML_Mouse2.31633970
15LXR_22292898_ChIP-Seq_THP-1_Human2.30375380
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29361855
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.26568563
18MAF_26560356_Chip-Seq_TH1_Human2.25011973
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23770826
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23349863
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.21267999
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.17396201
23RUNX_20019798_ChIP-Seq_JUKART_Human2.08846885
24KDM2B_26808549_Chip-Seq_DND41_Human2.08301244
25SCL_19346495_ChIP-Seq_HPC-7_Human2.08219196
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05984149
27ELK3_25401928_ChIP-Seq_HUVEC_Human2.03655150
28SPI1_23127762_ChIP-Seq_K562_Human2.02256924
29UTX_26944678_Chip-Seq_JUKART_Human2.01770758
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.98869385
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97392858
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.95616328
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.93462406
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90019165
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85477580
36MYB_26560356_Chip-Seq_TH2_Human1.83212340
37SPI1_23547873_ChIP-Seq_NB4_Human1.81729988
38MAF_26560356_Chip-Seq_TH2_Human1.79055865
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76737240
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75221065
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74566254
42MYB_26560356_Chip-Seq_TH1_Human1.70738931
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.66991058
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66210448
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60178254
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55725251
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53095325
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50723386
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.49986440
50VDR_24787735_ChIP-Seq_THP-1_Human1.47307046
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47256643
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46588841
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.44588931
54PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41646674
55RACK7_27058665_Chip-Seq_MCF-7_Human1.41283324
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.38745384
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.37316727
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36112308
59BCOR_27268052_Chip-Seq_Bcells_Human1.31109375
60GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28582328
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28433748
62GATA1_19941826_ChIP-Seq_K562_Human1.27958924
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27434265
64BCL6_27268052_Chip-Seq_Bcells_Human1.25208414
65P68_20966046_ChIP-Seq_HELA_Human1.25076302
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24908159
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23540649
68GATA3_27048872_Chip-Seq_THYMUS_Human1.22828187
69SMC4_20622854_ChIP-Seq_HELA_Human1.22690204
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21335741
71NCOR1_26117541_ChIP-Seq_K562_Human1.19924496
72SA1_27219007_Chip-Seq_ERYTHROID_Human1.18677602
73MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17839617
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17830263
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16698421
76KDM2B_26808549_Chip-Seq_K562_Human1.16547908
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15675912
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15180667
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14864010
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11762842
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09768768
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08755117
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08052017
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06037909
85PU_27001747_Chip-Seq_BMDM_Mouse1.04307227
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04004395
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.03742682
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03416099
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00034419
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99531087
91PPARA_22158963_ChIP-Seq_LIVER_Mouse0.97511330
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96302753
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95071790
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94248362
95GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93707704
96GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93479623
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93337012
98P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92876921
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91792463
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91236922

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.69131499
2MP0001835_abnormal_antigen_presentation3.45727988
3MP0000685_abnormal_immune_system2.88453864
4MP0003303_peritoneal_inflammation2.79083400
5MP0002419_abnormal_innate_immunity2.64550200
6MP0001800_abnormal_humoral_immune2.56986760
7MP0005387_immune_system_phenotype2.55689168
8MP0001790_abnormal_immune_system2.55689168
9MP0003724_increased_susceptibility_to2.49767321
10MP0003172_abnormal_lysosome_physiology2.46651043
11MP0005000_abnormal_immune_tolerance2.44347341
12MP0005025_abnormal_response_to2.42983805
13MP0003763_abnormal_thymus_physiology2.40056266
14MP0003300_gastrointestinal_ulcer2.36056268
15MP0005058_abnormal_lysosome_morphology2.31042761
16MP0005671_abnormal_response_to2.29175592
17MP0002452_abnormal_antigen_presenting2.27548683
18MP0002723_abnormal_immune_serum2.23895479
19MP0009278_abnormal_bone_marrow2.18250188
20MP0002420_abnormal_adaptive_immunity2.16954422
21MP0001819_abnormal_immune_cell2.14565618
22MP0003191_abnormal_cellular_cholesterol2.10599180
23MP0004947_skin_inflammation2.04981887
24MP0005451_abnormal_body_composition2.04062796
25MP0009785_altered_susceptibility_to2.01016006
26MP0005464_abnormal_platelet_physiology1.90065396
27MP0006082_CNS_inflammation1.87390639
28MP0002148_abnormal_hypersensitivity_rea1.86313121
29MP0008260_abnormal_autophagy1.85255947
30MP0002396_abnormal_hematopoietic_system1.84591220
31MP0001533_abnormal_skeleton_physiology1.82836505
32MP0002405_respiratory_system_inflammati1.81699057
33MP0002398_abnormal_bone_marrow1.79488135
34MP0010155_abnormal_intestine_physiology1.72517158
35MP0000716_abnormal_immune_system1.71965180
36MP0009333_abnormal_splenocyte_physiolog1.69193631
37MP0005076_abnormal_cell_differentiation1.58689725
38MP0003828_pulmonary_edema1.58343180
39MP0001545_abnormal_hematopoietic_system1.56516083
40MP0005397_hematopoietic_system_phenotyp1.56516083
41MP0002998_abnormal_bone_remodeling1.54884898
42MP0005310_abnormal_salivary_gland1.51542964
43MP0009840_abnormal_foam_cell1.51358241
44MP0002166_altered_tumor_susceptibility1.50846090
45MP0001845_abnormal_inflammatory_respons1.50388211
46MP0002722_abnormal_immune_system1.50252480
47MP0001853_heart_inflammation1.48492678
48MP0000689_abnormal_spleen_morphology1.47611793
49MP0002132_abnormal_respiratory_system1.47522867
50MP0003705_abnormal_hypodermis_morpholog1.46657603
51MP0002429_abnormal_blood_cell1.41908797
52MP0000858_altered_metastatic_potential1.37872858
53MP0000703_abnormal_thymus_morphology1.36260006
54MP0003091_abnormal_cell_migration1.35729334
55MP0003183_abnormal_peptide_metabolism1.32356891
56MP0005410_abnormal_fertilization1.29817797
57MP0001873_stomach_inflammation1.28554395
58MP0008469_abnormal_protein_level1.27040828
59MP0003866_abnormal_defecation1.23037951
60MP0004808_abnormal_hematopoietic_stem1.22155504
61MP0001851_eye_inflammation1.16580661
62MP0000465_gastrointestinal_hemorrhage1.14935550
63MP0002138_abnormal_hepatobiliary_system1.14237405
64MP0001348_abnormal_lacrimal_gland1.09809830
65MP0004883_abnormal_blood_vessel1.08382491
66MP0000604_amyloidosis1.08330935
67MP0003566_abnormal_cell_adhesion1.04719942
68MP0002933_joint_inflammation1.04327627
69MP0001958_emphysema1.03263076
70MP0003075_altered_response_to1.01882646
71MP0004381_abnormal_hair_follicle1.00788911
72MP0002009_preneoplasia0.99663168
73MP0003453_abnormal_keratinocyte_physiol0.99197777
74MP0005166_decreased_susceptibility_to0.98439958
75MP0004264_abnormal_extraembryonic_tissu0.96466955
76MP0005164_abnormal_response_to0.95685257
77MP0002006_tumorigenesis0.93819101
78MP0003448_altered_tumor_morphology0.92924111
79MP0009764_decreased_sensitivity_to0.90807422
80MP0000249_abnormal_blood_vessel0.90456620
81MP0001849_ear_inflammation0.89811688
82MP0005360_urolithiasis0.89550511
83MP0009115_abnormal_fat_cell0.88807957
84MP0005670_abnormal_white_adipose0.85617061
85MP0005390_skeleton_phenotype0.85122840
86MP0000490_abnormal_crypts_of0.84513952
87MP0004510_myositis0.83238446
88MP0005666_abnormal_adipose_tissue0.82973266
89MP0005409_darkened_coat_color0.79971382
90MP0008004_abnormal_stomach_pH0.78842941
91MP0005023_abnormal_wound_healing0.78732078
92MP0010234_abnormal_vibrissa_follicle0.74748947
93MP0003279_aneurysm0.72952836
94MP0003795_abnormal_bone_structure0.72489394
95MP0009763_increased_sensitivity_to0.70995700
96MP0003656_abnormal_erythrocyte_physiolo0.69975401
97MP0000343_altered_response_to0.68920282
98MP0004185_abnormal_adipocyte_glucose0.68613394
99MP0003690_abnormal_glial_cell0.66010291
100MP0000609_abnormal_liver_physiology0.64590029

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.03584850
2Recurrent abscess formation (HP:0002722)4.25665377
3Recurrent bacterial skin infections (HP:0005406)4.23085788
4Abnormality of macrophages (HP:0004311)4.18931185
5Recurrent fungal infections (HP:0002841)3.58522520
6Cellulitis (HP:0100658)3.50192690
7Myositis (HP:0100614)3.45992766
8Recurrent gram-negative bacterial infections (HP:0005420)3.45124698
9Meningitis (HP:0001287)3.43411631
10Colitis (HP:0002583)3.33559546
11Mediastinal lymphadenopathy (HP:0100721)3.30156980
12Increased IgE level (HP:0003212)3.26062549
13Chronic mucocutaneous candidiasis (HP:0002728)3.24498750
14Recurrent cutaneous fungal infections (HP:0011370)3.24498750
15Recurrent viral infections (HP:0004429)3.24178802
16Agammaglobulinemia (HP:0004432)3.21413293
17Elevated erythrocyte sedimentation rate (HP:0003565)3.17043972
18Gingivitis (HP:0000230)3.14654591
19Recurrent skin infections (HP:0001581)3.12421054
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.11156128
21Obstructive lung disease (HP:0006536)3.05681524
22Chronic obstructive pulmonary disease (HP:0006510)3.05681524
23Orchitis (HP:0100796)3.04110037
24Panhypogammaglobulinemia (HP:0003139)3.01612537
25Gastrointestinal inflammation (HP:0004386)2.96384252
26Inflammation of the large intestine (HP:0002037)2.94363209
27Systemic lupus erythematosus (HP:0002725)2.82588575
28Increased cerebral lipofuscin (HP:0011813)2.75542703
29Gastrointestinal infarctions (HP:0005244)2.75161772
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.73790274
31Vasculitis (HP:0002633)2.70458108
32Optic neuritis (HP:0100653)2.68343209
33Retrobulbar optic neuritis (HP:0100654)2.68343209
34Dysostosis multiplex (HP:0000943)2.61994711
35Pustule (HP:0200039)2.51451796
36Spontaneous hematomas (HP:0007420)2.50955943
37Abnormality of glycolipid metabolism (HP:0010969)2.50165188
38Abnormality of liposaccharide metabolism (HP:0010968)2.50165188
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.50165188
40Amyloidosis (HP:0011034)2.47937215
41Osteomyelitis (HP:0002754)2.46106685
42Prolonged bleeding time (HP:0003010)2.40752058
43Gastrointestinal stroma tumor (HP:0100723)2.34929790
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.32535635
45Epistaxis (HP:0000421)2.32522454
46Pulmonary infiltrates (HP:0002113)2.31323057
47Stomatitis (HP:0010280)2.27128291
48Urticaria (HP:0001025)2.25118959
49Granulocytopenia (HP:0001913)2.24745308
50Nasal polyposis (HP:0100582)2.24227126
51Encephalitis (HP:0002383)2.22169372
52Chest pain (HP:0100749)2.21307785
53Malnutrition (HP:0004395)2.20698707
54Asymmetric septal hypertrophy (HP:0001670)2.19322819
55Spondylolisthesis (HP:0003302)2.16700047
56Abnormality of the nasal mucosa (HP:0000433)2.14960481
57Abnormality of the fingertips (HP:0001211)2.14920401
58Papilloma (HP:0012740)2.14475329
59Verrucae (HP:0200043)2.14475329
60Polygenic inheritance (HP:0010982)2.12564078
61Recurrent pneumonia (HP:0006532)2.12351343
62Urinary glycosaminoglycan excretion (HP:0003541)2.11569261
63Mucopolysacchariduria (HP:0008155)2.11569261
64Hemoptysis (HP:0002105)2.10412352
65T lymphocytopenia (HP:0005403)2.09218775
66Emphysema (HP:0002097)2.08706239
67Leukocytosis (HP:0001974)2.07651097
68Vacuolated lymphocytes (HP:0001922)2.06458631
69Recurrent lower respiratory tract infections (HP:0002783)2.05983552
70Gingival bleeding (HP:0000225)2.05880122
71Purpura (HP:0000979)2.05869301
72Abnormality of polysaccharide metabolism (HP:0011012)2.05704689
73Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05704689
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05704689
75Loss of speech (HP:0002371)2.05419649
76Peritonitis (HP:0002586)2.03141669
77Restrictive lung disease (HP:0002091)2.01860004
78Broad face (HP:0000283)2.01824769
79Abnormality of the peritoneum (HP:0002585)2.01339257
80Fatigue (HP:0012378)1.99579494
81Abnormality of T cells (HP:0002843)1.98359748
82Thin bony cortex (HP:0002753)1.98214164
83Skin ulcer (HP:0200042)1.97663074
84Keratoconjunctivitis sicca (HP:0001097)1.96691093
85Slow saccadic eye movements (HP:0000514)1.96371613
86Viral hepatitis (HP:0006562)1.94846740
87Interstitial pulmonary disease (HP:0006530)1.94118923
88Recurrent bronchitis (HP:0002837)1.93110171
89Abnormality of T cell number (HP:0011839)1.92622237
90Abnormality of T cell physiology (HP:0011840)1.92609373
91Hemorrhage of the eye (HP:0011885)1.91303619
92Autoimmune thrombocytopenia (HP:0001973)1.91075848
93Thoracic kyphosis (HP:0002942)1.90749048
94Arterial thrombosis (HP:0004420)1.90234476
95Sepsis (HP:0100806)1.89053803
96Lymphopenia (HP:0001888)1.86704200
97Myocardial infarction (HP:0001658)1.86324486
98Increased serum ferritin (HP:0003281)1.83417329
99Thrombocytosis (HP:0001894)1.83249425
100Hypertriglyceridemia (HP:0002155)1.80857200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.51070688
2ERN13.48788961
3RIPK43.34865686
4MAP4K13.23806723
5CDK122.65131295
6BLK2.57897493
7TRIB32.52305715
8TYK22.29410409
9MAP2K32.20838169
10MAP3K132.06330712
11MAP3K141.89127502
12SMG11.83907503
13ZAP701.77405090
14FES1.75497751
15IRAK41.71624825
16JAK31.70440960
17GRK61.59779695
18CSK1.57044640
19CSF1R1.54717341
20MAP3K31.51607952
21TBK11.51077278
22BTK1.45873254
23SIK11.44064305
24ICK1.40176808
25MAP3K101.36259309
26SYK1.35472631
27KIT1.31062792
28IRAK31.30815497
29MAP3K111.30421119
30IKBKE1.25431723
31PDPK11.22981153
32TNK21.22193732
33MAP3K11.22088553
34MARK21.19859807
35PDK11.16675151
36FGFR41.15631163
37HCK1.15371766
38JAK11.11054851
39BRD41.10557240
40CDC42BPA1.06319989
41EPHB11.05882990
42KSR21.04440867
43TGFBR20.99593758
44SIK20.99377620
45RIPK10.99063697
46EEF2K0.97135948
47SIK30.97049371
48TESK20.95999788
49TESK10.93540287
50IKBKB0.91256804
51LYN0.90105785
52MAPK110.87663232
53ITK0.87273437
54LCK0.86059741
55MAPK120.85355721
56STK100.84704912
57MAPK70.84509866
58JAK20.83873185
59MAP3K70.83092920
60TAOK10.82968066
61CDK40.80855151
62FGR0.80263617
63MAP2K20.79680780
64PRKD20.78583948
65PIK3CG0.78004449
66CDK60.77087321
67TAOK20.76254557
68FGFR30.75835380
69PKN20.73773559
70RPS6KL10.72794630
71RPS6KC10.72794630
72RPS6KA20.72473751
73TTN0.70991757
74STK380.70700428
75MST1R0.70502467
76TAOK30.66666995
77HIPK20.65210576
78MAP3K20.64374540
79PTK60.63998117
80DDR20.63111024
81MAP3K80.62285624
82IRAK20.62106726
83MAP3K60.62103689
84NEK90.60982857
85DYRK1B0.60889567
86MTOR0.60559361
87TXK0.60083531
88TEC0.57823369
89RPS6KA60.54808858
90BMPR20.51602977
91MARK30.50505863
92RET0.47954502
93MOS0.47477041
94MAPKAPK20.47246639
95CAMK1D0.45027866
96SGK30.44081636
97LRRK20.43809851
98IRAK10.43737067
99CDK90.43016232
100MATK0.43003283

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.70415700
2Leishmaniasis_Homo sapiens_hsa051402.57875800
3B cell receptor signaling pathway_Homo sapiens_hsa046622.49962668
4Staphylococcus aureus infection_Homo sapiens_hsa051502.48657547
5Osteoclast differentiation_Homo sapiens_hsa043802.43955777
6Allograft rejection_Homo sapiens_hsa053302.21613458
7Autoimmune thyroid disease_Homo sapiens_hsa053202.10265645
8Graft-versus-host disease_Homo sapiens_hsa053322.08732436
9Acute myeloid leukemia_Homo sapiens_hsa052212.08705466
10Primary immunodeficiency_Homo sapiens_hsa053402.00267780
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97297262
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83135000
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.78010569
14Tuberculosis_Homo sapiens_hsa051521.77268591
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68059064
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67570877
17Toxoplasmosis_Homo sapiens_hsa051451.64807725
18Asthma_Homo sapiens_hsa053101.62588440
19Antigen processing and presentation_Homo sapiens_hsa046121.62526234
20Influenza A_Homo sapiens_hsa051641.62487199
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.57452334
22Hematopoietic cell lineage_Homo sapiens_hsa046401.53779738
23Viral myocarditis_Homo sapiens_hsa054161.52321943
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.49991754
25Type I diabetes mellitus_Homo sapiens_hsa049401.47879436
26T cell receptor signaling pathway_Homo sapiens_hsa046601.47679832
27Non-small cell lung cancer_Homo sapiens_hsa052231.46472727
28Chronic myeloid leukemia_Homo sapiens_hsa052201.46427677
29Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43303442
30Measles_Homo sapiens_hsa051621.40299033
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39804705
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.34364489
33Herpes simplex infection_Homo sapiens_hsa051681.33090320
34Hepatitis B_Homo sapiens_hsa051611.22357009
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.21994503
36Pancreatic cancer_Homo sapiens_hsa052121.19225831
37TNF signaling pathway_Homo sapiens_hsa046681.18386682
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18030165
39Lysosome_Homo sapiens_hsa041421.12876376
40Pertussis_Homo sapiens_hsa051331.12612620
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.12511705
42Chemokine signaling pathway_Homo sapiens_hsa040621.12302499
43Malaria_Homo sapiens_hsa051441.11890777
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10875630
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.07789117
46VEGF signaling pathway_Homo sapiens_hsa043701.06507226
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03399639
48Hepatitis C_Homo sapiens_hsa051601.01161154
49Phagosome_Homo sapiens_hsa041451.00138327
50Notch signaling pathway_Homo sapiens_hsa043300.99877661
51Platelet activation_Homo sapiens_hsa046110.98933190
52Apoptosis_Homo sapiens_hsa042100.98057637
53Legionellosis_Homo sapiens_hsa051340.97535748
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.91779678
55Renal cell carcinoma_Homo sapiens_hsa052110.91600200
56Prolactin signaling pathway_Homo sapiens_hsa049170.86704277
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85939014
58HTLV-I infection_Homo sapiens_hsa051660.80297651
59Shigellosis_Homo sapiens_hsa051310.78427302
60Viral carcinogenesis_Homo sapiens_hsa052030.77477602
61Bladder cancer_Homo sapiens_hsa052190.76615002
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.75574417
63Endometrial cancer_Homo sapiens_hsa052130.74353069
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.73286211
65Sphingolipid signaling pathway_Homo sapiens_hsa040710.72267003
66Epstein-Barr virus infection_Homo sapiens_hsa051690.72057117
67Endocytosis_Homo sapiens_hsa041440.71427199
68mTOR signaling pathway_Homo sapiens_hsa041500.71048355
69Inositol phosphate metabolism_Homo sapiens_hsa005620.70629037
70Choline metabolism in cancer_Homo sapiens_hsa052310.70028880
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68046806
72Rheumatoid arthritis_Homo sapiens_hsa053230.66864825
73GnRH signaling pathway_Homo sapiens_hsa049120.66433482
74Amoebiasis_Homo sapiens_hsa051460.66287314
75Salmonella infection_Homo sapiens_hsa051320.64460133
76Insulin resistance_Homo sapiens_hsa049310.61999240
77Prostate cancer_Homo sapiens_hsa052150.61560506
78Dorso-ventral axis formation_Homo sapiens_hsa043200.60731997
79HIF-1 signaling pathway_Homo sapiens_hsa040660.59340428
80Colorectal cancer_Homo sapiens_hsa052100.58103684
81African trypanosomiasis_Homo sapiens_hsa051430.58001843
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.57714739
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57519178
84Galactose metabolism_Homo sapiens_hsa000520.56921786
85FoxO signaling pathway_Homo sapiens_hsa040680.56112755
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54023633
87Thyroid cancer_Homo sapiens_hsa052160.53934104
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53370336
89Glioma_Homo sapiens_hsa052140.53325636
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.52998108
91ErbB signaling pathway_Homo sapiens_hsa040120.52511247
92Estrogen signaling pathway_Homo sapiens_hsa049150.50163221
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49370688
94Complement and coagulation cascades_Homo sapiens_hsa046100.47093314
95Prion diseases_Homo sapiens_hsa050200.46753286
96Pentose phosphate pathway_Homo sapiens_hsa000300.45290097
97MAPK signaling pathway_Homo sapiens_hsa040100.44836705
98Fructose and mannose metabolism_Homo sapiens_hsa000510.44502665
99Small cell lung cancer_Homo sapiens_hsa052220.44259635
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42797892

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »