TTC7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.07036303
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.01896231
3locomotory exploration behavior (GO:0035641)5.68863174
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.63768519
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21790326
6glutamate secretion (GO:0014047)5.08527028
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.00572017
8synaptic vesicle exocytosis (GO:0016079)4.83140111
9regulation of synaptic vesicle exocytosis (GO:2000300)4.77319255
10behavioral response to nicotine (GO:0035095)4.62731598
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.53952678
12vocalization behavior (GO:0071625)4.49794397
13regulation of glutamate receptor signaling pathway (GO:1900449)4.40688536
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36126695
15activation of protein kinase A activity (GO:0034199)4.32436565
16regulation of synaptic vesicle transport (GO:1902803)4.30064726
17sodium ion export (GO:0071436)4.26378423
18regulation of synapse structural plasticity (GO:0051823)4.22493805
19neurotransmitter secretion (GO:0007269)4.19492454
20neuronal action potential propagation (GO:0019227)4.13583456
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.12239221
22regulation of neuronal synaptic plasticity (GO:0048168)4.03353222
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02075211
24kynurenine metabolic process (GO:0070189)3.97930536
25cellular potassium ion homeostasis (GO:0030007)3.97302757
26indole-containing compound catabolic process (GO:0042436)3.93447070
27indolalkylamine catabolic process (GO:0046218)3.93447070
28tryptophan catabolic process (GO:0006569)3.93447070
29proline transport (GO:0015824)3.93215538
30exploration behavior (GO:0035640)3.92844674
31cell communication by electrical coupling (GO:0010644)3.91449633
32ionotropic glutamate receptor signaling pathway (GO:0035235)3.84673922
33layer formation in cerebral cortex (GO:0021819)3.69360457
34protein localization to synapse (GO:0035418)3.68877941
35serotonin metabolic process (GO:0042428)3.67552280
36indolalkylamine metabolic process (GO:0006586)3.65819950
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.65494404
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.59688915
39transmission of nerve impulse (GO:0019226)3.57175017
40synaptic transmission, glutamatergic (GO:0035249)3.51965202
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51842315
42primary amino compound metabolic process (GO:1901160)3.50222972
43long-term memory (GO:0007616)3.49064174
44regulation of hippo signaling (GO:0035330)3.48030692
45neuromuscular process controlling posture (GO:0050884)3.45835300
46gamma-aminobutyric acid transport (GO:0015812)3.45328713
47regulation of dendritic spine morphogenesis (GO:0061001)3.44714967
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.43062208
49neuromuscular process controlling balance (GO:0050885)3.40503025
50neurotransmitter-gated ion channel clustering (GO:0072578)3.40388808
51regulation of ARF protein signal transduction (GO:0032012)3.37939354
52cerebellar Purkinje cell differentiation (GO:0021702)3.37558683
53neuron-neuron synaptic transmission (GO:0007270)3.29479694
54positive regulation of membrane potential (GO:0045838)3.29378198
55regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29320240
56indole-containing compound metabolic process (GO:0042430)3.29025579
57reflex (GO:0060004)3.27641312
58positive regulation of neurotransmitter secretion (GO:0001956)3.27347728
59glutamate receptor signaling pathway (GO:0007215)3.26776456
60regulation of synaptic plasticity (GO:0048167)3.26431172
61dendritic spine morphogenesis (GO:0060997)3.25841351
62detection of light stimulus involved in visual perception (GO:0050908)3.24887944
63detection of light stimulus involved in sensory perception (GO:0050962)3.24887944
64potassium ion import (GO:0010107)3.24383891
65positive regulation of neurotransmitter transport (GO:0051590)3.22630792
66regulation of postsynaptic membrane potential (GO:0060078)3.22116372
67regulation of clathrin-mediated endocytosis (GO:2000369)3.22064518
68neurotransmitter transport (GO:0006836)3.21272681
69positive regulation of synapse maturation (GO:0090129)3.21205932
70tryptophan metabolic process (GO:0006568)3.20930587
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18337454
72membrane depolarization during action potential (GO:0086010)3.18076003
73regulation of neurotransmitter secretion (GO:0046928)3.17553594
74regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.17291921
75postsynaptic membrane organization (GO:0001941)3.17098486
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.16969655
77regulation of gene silencing by RNA (GO:0060966)3.16411393
78regulation of posttranscriptional gene silencing (GO:0060147)3.16411393
79regulation of gene silencing by miRNA (GO:0060964)3.16411393
80glycine transport (GO:0015816)3.14519502
81prepulse inhibition (GO:0060134)3.13184674
82neuronal action potential (GO:0019228)3.11983345
83gamma-aminobutyric acid signaling pathway (GO:0007214)3.11429136
84regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05478394
85negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04803850
86regulation of neurotransmitter levels (GO:0001505)3.04370710
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03988124
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.03451867
89vesicle transport along microtubule (GO:0047496)3.03160850
90plasma membrane repair (GO:0001778)3.02310140
91regulation of calcium ion transmembrane transport (GO:1903169)3.01875204
92regulation of calcium ion transmembrane transporter activity (GO:1901019)3.01875204
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.01485246
94synaptic vesicle endocytosis (GO:0048488)3.00227030
95regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.99922196
96regulation of voltage-gated calcium channel activity (GO:1901385)2.97190737
97regulation of neurotransmitter transport (GO:0051588)2.95821733
98cell communication involved in cardiac conduction (GO:0086065)2.95784298
99regulation of ion transmembrane transporter activity (GO:0032412)2.95708486
100interkinetic nuclear migration (GO:0022027)2.94993271
101establishment of nucleus localization (GO:0040023)2.92471068
102negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91045640
103nerve growth factor signaling pathway (GO:0038180)2.90993462
104positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90426690
105regulation of sodium ion transmembrane transporter activity (GO:2000649)2.89255102
106sulfation (GO:0051923)2.88950968
107alanine transport (GO:0032328)2.88480577
108regulation of sarcomere organization (GO:0060297)2.86332727
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85464772
110membrane depolarization (GO:0051899)2.85345885
111long-term synaptic potentiation (GO:0060291)2.85119896
112regulation of transmembrane transporter activity (GO:0022898)2.85086567
113regulation of membrane repolarization (GO:0060306)2.84050086
114L-amino acid import (GO:0043092)2.83413464
115positive regulation of sodium ion transport (GO:0010765)2.81907384
116regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81730981
117neuromuscular synaptic transmission (GO:0007274)2.81372063
118cellular sodium ion homeostasis (GO:0006883)2.80018092
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.79846673
120central nervous system myelination (GO:0022010)2.79667527
121axon ensheathment in central nervous system (GO:0032291)2.79667527
122negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79055226
123regulation of dendritic spine development (GO:0060998)2.78811587
124NAD biosynthetic process (GO:0009435)2.77548237
125chemosensory behavior (GO:0007635)2.77399417
126potassium ion transmembrane transport (GO:0071805)2.76850392
127cellular potassium ion transport (GO:0071804)2.76850392
128negative regulation of potassium ion transmembrane transport (GO:1901380)2.76801698
129auditory receptor cell stereocilium organization (GO:0060088)2.76458598
130fucose catabolic process (GO:0019317)2.74842405
131L-fucose metabolic process (GO:0042354)2.74842405
132L-fucose catabolic process (GO:0042355)2.74842405
133regulation of neurotransmitter uptake (GO:0051580)2.74734474
134negative regulation of translation, ncRNA-mediated (GO:0040033)2.72944713
135regulation of translation, ncRNA-mediated (GO:0045974)2.72944713
136negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.72944713
137positive regulation of synaptic transmission (GO:0050806)2.72833355
138neuromuscular process (GO:0050905)2.72590709
139long term synaptic depression (GO:0060292)2.72219203
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.71827514
141startle response (GO:0001964)2.70563609
142cAMP catabolic process (GO:0006198)2.69961399
143positive regulation of potassium ion transmembrane transport (GO:1901381)2.69753165
144cellular biogenic amine catabolic process (GO:0042402)2.68904408
145amine catabolic process (GO:0009310)2.68904408
146cyclic nucleotide catabolic process (GO:0009214)2.66204331
147cellular response to ATP (GO:0071318)2.65916075
148regulation of female receptivity (GO:0045924)2.63880142
149behavioral response to ethanol (GO:0048149)2.63195413
150protein K48-linked deubiquitination (GO:0071108)2.59820692
151righting reflex (GO:0060013)2.59070063
152potassium ion transport (GO:0006813)2.58830222
153cilium or flagellum-dependent cell motility (GO:0001539)2.57978709
154action potential (GO:0001508)2.57516474
155detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56755760
156regulation of skeletal muscle contraction (GO:0014819)2.56753987
157regulation of pigment cell differentiation (GO:0050932)2.55362129
158positive regulation of sodium ion transmembrane transport (GO:1902307)2.53255324
159negative regulation of protein localization to cell surface (GO:2000009)2.51984804
160multicellular organismal signaling (GO:0035637)2.51936907
161cellular ketone body metabolic process (GO:0046950)2.48611830
162phosphorelay signal transduction system (GO:0000160)2.43598547
163auditory behavior (GO:0031223)2.42655125
164signal peptide processing (GO:0006465)2.40665462
165negative regulation of sodium ion transport (GO:0010766)2.40339839
166calcium ion import (GO:0070509)2.39741120
167urinary tract smooth muscle contraction (GO:0014848)2.39215865
168regulation of synapse maturation (GO:0090128)2.38558956
169protein K11-linked deubiquitination (GO:0035871)2.37949755
170positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.36224892
171regulation of action potential (GO:0098900)2.36223534
172negative regulation of systemic arterial blood pressure (GO:0003085)2.35109987
173neuron cell-cell adhesion (GO:0007158)2.34769583
174regulation of calcium ion-dependent exocytosis (GO:0017158)2.33843188

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.92130663
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.18991246
3DROSHA_22980978_ChIP-Seq_HELA_Human2.87359161
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.65255892
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62803623
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60079641
7MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.58089681
8VDR_22108803_ChIP-Seq_LS180_Human2.57069167
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.52798643
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42527683
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.42078589
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.42078589
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.37930282
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.32169394
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24214831
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.23191078
17GBX2_23144817_ChIP-Seq_PC3_Human2.21194477
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14046187
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12176408
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04314392
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.99426261
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.99376052
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98150036
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.92078444
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88049313
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.86874764
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83494836
28IGF1R_20145208_ChIP-Seq_DFB_Human1.79374091
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79166014
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.78635652
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.78427363
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.78395985
33KDM2B_26808549_Chip-Seq_K562_Human1.77198173
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75759683
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.72243483
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69580819
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68676075
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66501618
39P300_19829295_ChIP-Seq_ESCs_Human1.66233421
40TAF15_26573619_Chip-Seq_HEK293_Human1.65723879
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.64910963
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.64449457
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64409058
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.63991987
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.63610166
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58858808
47TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58286242
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58286242
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56916223
50ER_23166858_ChIP-Seq_MCF-7_Human1.56223234
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55365609
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54195422
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.54137510
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53605814
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.45846741
56AR_21572438_ChIP-Seq_LNCaP_Human1.45492440
57BCAT_22108803_ChIP-Seq_LS180_Human1.43785621
58* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42802012
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42429454
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.42196745
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41893808
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41460216
63RNF2_27304074_Chip-Seq_NSC_Mouse1.36845721
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36611652
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36446443
66FUS_26573619_Chip-Seq_HEK293_Human1.36266716
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36168590
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.35397013
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34598435
70AR_19668381_ChIP-Seq_PC3_Human1.32329330
71KDM2B_26808549_Chip-Seq_DND41_Human1.32152041
72* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30401213
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.30307348
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30040850
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.29420494
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27621262
77TP53_16413492_ChIP-PET_HCT116_Human1.27575782
78SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26706713
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24615174
80NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24347930
81* EWS_26573619_Chip-Seq_HEK293_Human1.23646814
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22388110
83* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22137054
84* SMAD4_21799915_ChIP-Seq_A2780_Human1.21646598
85CBP_20019798_ChIP-Seq_JUKART_Human1.21544921
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21544921
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20459823
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.20390442
89LXR_22292898_ChIP-Seq_THP-1_Human1.20179675
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.17383311
91RXR_22108803_ChIP-Seq_LS180_Human1.15627561
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.15239092
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.14451025
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.14160866
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13012543
96RUNX2_22187159_ChIP-Seq_PCA_Human1.12333407
97* FLI1_21867929_ChIP-Seq_TH2_Mouse1.11126370
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11101585
99ZNF274_21170338_ChIP-Seq_K562_Hela1.10964113
100ZNF263_19887448_ChIP-Seq_K562_Human1.10903607
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10655514
102* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09723657
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09487090
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09400831
105TCF4_22108803_ChIP-Seq_LS180_Human1.08479972
106KDM2B_26808549_Chip-Seq_JURKAT_Human1.07874832
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07768961
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06717767
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06101071
110P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05741582
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.05615446
112KDM2B_26808549_Chip-Seq_REH_Human1.05105436
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04337040
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.04152763
115RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04057161
116KLF4_19829295_ChIP-Seq_ESCs_Human1.03808334
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03339074
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02795037
119CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02527785
120SMC4_20622854_ChIP-Seq_HELA_Human1.02238659
121CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01901056
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01611008
123EP300_21415370_ChIP-Seq_HL-1_Mouse1.01154478
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00807399
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99152139
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98967092
127* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.98761762
128NANOG_19829295_ChIP-Seq_ESCs_Human0.98197138
129SOX2_19829295_ChIP-Seq_ESCs_Human0.98197138
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98156503
131STAT3_23295773_ChIP-Seq_U87_Human0.98106315
132CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97106734
133CTCF_27219007_Chip-Seq_Bcells_Human0.96964178
134AHR_22903824_ChIP-Seq_MCF-7_Human0.96183712
135KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96070593
136* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95605735
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94405641
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94131419
139* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93072413
140VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91943714
141YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91569125
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.91124223
143AR_25329375_ChIP-Seq_VCAP_Human0.90351630
144CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89933596
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.89714322
146ARNT_22903824_ChIP-Seq_MCF-7_Human0.89109740
147OCT4_19829295_ChIP-Seq_ESCs_Human0.88068253
148CREB1_26743006_Chip-Seq_LNCaP_Human0.87774010
149PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.87715180
150SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86805103
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.86095398
152* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85721999
153* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85462151
154TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85079547
155* TCF4_23295773_ChIP-Seq_U87_Human0.82011362

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.86252919
2MP0003635_abnormal_synaptic_transmissio3.83972724
3MP0003880_abnormal_central_pattern3.28752122
4MP0004270_analgesia3.24126336
5MP0002822_catalepsy3.08778678
6MP0009745_abnormal_behavioral_response2.98440438
7MP0002063_abnormal_learning/memory/cond2.96083080
8MP0002064_seizures2.84147439
9MP0009046_muscle_twitch2.82694719
10MP0000751_myopathy2.64559057
11MP0002837_dystrophic_cardiac_calcinosis2.47513929
12MP0003646_muscle_fatigue2.36977775
13MP0002909_abnormal_adrenal_gland2.29478565
14MP0002572_abnormal_emotion/affect_behav2.25287244
15MP0002272_abnormal_nervous_system2.18245347
16MP0001968_abnormal_touch/_nociception2.15584805
17MP0003195_calcinosis2.10046506
18MP0005423_abnormal_somatic_nervous2.08919252
19MP0009780_abnormal_chondrocyte_physiolo2.07888160
20MP0004130_abnormal_muscle_cell2.05091507
21MP0001486_abnormal_startle_reflex2.05043480
22MP0001501_abnormal_sleep_pattern2.03913027
23MP0005551_abnormal_eye_electrophysiolog2.02550361
24MP0008569_lethality_at_weaning1.96702715
25MP0002734_abnormal_mechanical_nocicepti1.95615389
26MP0004215_abnormal_myocardial_fiber1.91843814
27MP0001485_abnormal_pinna_reflex1.89819544
28MP0004858_abnormal_nervous_system1.87340834
29MP0004145_abnormal_muscle_electrophysio1.85004403
30MP0005167_abnormal_blood-brain_barrier1.72251174
31MP0004142_abnormal_muscle_tone1.66848671
32MP0001440_abnormal_grooming_behavior1.65018958
33MP0008961_abnormal_basal_metabolism1.64036308
34MP0004084_abnormal_cardiac_muscle1.61311696
35MP0004811_abnormal_neuron_physiology1.59961425
36MP0003633_abnormal_nervous_system1.59035172
37MP0002067_abnormal_sensory_capabilities1.54075452
38MP0004924_abnormal_behavior1.54021937
39MP0005386_behavior/neurological_phenoty1.54021937
40MP0004036_abnormal_muscle_relaxation1.50612780
41MP0008877_abnormal_DNA_methylation1.50456194
42MP0000569_abnormal_digit_pigmentation1.46503223
43MP0004510_myositis1.46193594
44MP0001970_abnormal_pain_threshold1.45966881
45MP0002733_abnormal_thermal_nociception1.44732847
46MP0002735_abnormal_chemical_nociception1.44101620
47MP0003329_amyloid_beta_deposits1.41807130
48MP0003136_yellow_coat_color1.41632364
49MP0005645_abnormal_hypothalamus_physiol1.41524729
50MP0002736_abnormal_nociception_after1.39323328
51MP0004484_altered_response_of1.38879669
52MP0000749_muscle_degeneration1.38499614
53MP0000747_muscle_weakness1.36724607
54MP0000631_abnormal_neuroendocrine_gland1.36692286
55MP0004087_abnormal_muscle_fiber1.34885713
56MP0003879_abnormal_hair_cell1.32752718
57MP0004147_increased_porphyrin_level1.32054842
58MP0004085_abnormal_heartbeat1.31353025
59MP0000013_abnormal_adipose_tissue1.29314733
60MP0003075_altered_response_to1.27288971
61MP0002638_abnormal_pupillary_reflex1.26351774
62MP0004233_abnormal_muscle_weight1.25460569
63MP0004742_abnormal_vestibular_system1.23985966
64MP0002066_abnormal_motor_capabilities/c1.23749859
65MP0003631_nervous_system_phenotype1.23080174
66MP0005620_abnormal_muscle_contractility1.21612385
67MP0002102_abnormal_ear_morphology1.21258815
68MP0000955_abnormal_spinal_cord1.21115495
69MP0002876_abnormal_thyroid_physiology1.20202739
70MP0003045_fibrosis1.18688229
71MP0000230_abnormal_systemic_arterial1.17819874
72MP0002557_abnormal_social/conspecific_i1.16828587
73MP0003787_abnormal_imprinting1.16782942
74MP0005535_abnormal_body_temperature1.16048934
75MP0002653_abnormal_ependyma_morphology1.15416499
76MP0002184_abnormal_innervation1.15096408
77MP0001905_abnormal_dopamine_level1.15053448
78MP0002269_muscular_atrophy1.13940240
79MP0004885_abnormal_endolymph1.13794771
80MP0005330_cardiomyopathy1.13424531
81MP0003690_abnormal_glial_cell1.11523771
82MP0003137_abnormal_impulse_conducting1.09544867
83MP0006292_abnormal_olfactory_placode1.08097172
84MP0010386_abnormal_urinary_bladder1.07145845
85MP0005646_abnormal_pituitary_gland1.06607323
86MP0001963_abnormal_hearing_physiology1.06094160
87MP0008874_decreased_physiological_sensi1.05361153
88MP0002972_abnormal_cardiac_muscle1.05154005
89MP0002882_abnormal_neuron_morphology1.03555211
90MP0001986_abnormal_taste_sensitivity1.01886795
91MP0005174_abnormal_tail_pigmentation1.00759103
92MP0006138_congestive_heart_failure1.00712552
93MP0000383_abnormal_hair_follicle1.00034038
94MP0002106_abnormal_muscle_physiology0.99431209
95MP0000759_abnormal_skeletal_muscle0.98240906
96MP0005623_abnormal_meninges_morphology0.97873893
97MP0005377_hearing/vestibular/ear_phenot0.97768655
98MP0003878_abnormal_ear_physiology0.97768655
99MP0005253_abnormal_eye_physiology0.97151171
100MP0008775_abnormal_heart_ventricle0.95012231
101MP0002160_abnormal_reproductive_system0.91859740
102MP0005448_abnormal_energy_balance0.91389441
103MP0001502_abnormal_circadian_rhythm0.90284153
104MP0001984_abnormal_olfaction0.89676562
105MP0002928_abnormal_bile_duct0.89279479
106MP0002234_abnormal_pharynx_morphology0.88433349
107MP0003283_abnormal_digestive_organ0.88252598
108MP0000427_abnormal_hair_cycle0.87615597
109MP0000026_abnormal_inner_ear0.87206283
110MP0005385_cardiovascular_system_phenoty0.86697702
111MP0001544_abnormal_cardiovascular_syste0.86697702
112MP0002752_abnormal_somatic_nervous0.85513062
113MP0004133_heterotaxia0.85471625
114MP0000003_abnormal_adipose_tissue0.84201713
115MP0002229_neurodegeneration0.83368130
116MP0003172_abnormal_lysosome_physiology0.81709614
117MP0005369_muscle_phenotype0.81346050
118MP0000778_abnormal_nervous_system0.81180363
119MP0003123_paternal_imprinting0.81107601
120MP0008872_abnormal_physiological_respon0.80843692
121MP0002069_abnormal_eating/drinking_beha0.80316909
122MP0002152_abnormal_brain_morphology0.80067766
123MP0005375_adipose_tissue_phenotype0.79945712
124MP0004043_abnormal_pH_regulation0.79294947
125MP0004185_abnormal_adipocyte_glucose0.79151753
126MP0002090_abnormal_vision0.78911653
127MP0005666_abnormal_adipose_tissue0.78796680
128MP0003122_maternal_imprinting0.78254047
129MP0008875_abnormal_xenobiotic_pharmacok0.77877646
130MP0005670_abnormal_white_adipose0.76122381
131MP0010234_abnormal_vibrissa_follicle0.75571914
132MP0003119_abnormal_digestive_system0.74983647
133MP0002332_abnormal_exercise_endurance0.74552495
134MP0003632_abnormal_nervous_system0.73324829
135MP0005171_absent_coat_pigmentation0.72475021
136MP0005410_abnormal_fertilization0.71047930
137MP0008057_abnormal_DNA_replication0.69119752
138MP0010630_abnormal_cardiac_muscle0.68995082
139MP0002938_white_spotting0.68889717
140MP0006276_abnormal_autonomic_nervous0.67002065

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.20589653
2Focal motor seizures (HP:0011153)6.14277704
3Focal seizures (HP:0007359)4.70121507
4Visual hallucinations (HP:0002367)4.62944175
5Bundle branch block (HP:0011710)3.85754356
6Action tremor (HP:0002345)3.83360990
7Pancreatic cysts (HP:0001737)3.78179064
8Dysmetric saccades (HP:0000641)3.76667161
9Epileptic encephalopathy (HP:0200134)3.66555002
10Atonic seizures (HP:0010819)3.60388850
11Urinary bladder sphincter dysfunction (HP:0002839)3.58081239
12Congenital stationary night blindness (HP:0007642)3.53536822
13Febrile seizures (HP:0002373)3.51050020
14Progressive cerebellar ataxia (HP:0002073)3.50475054
15Ventricular fibrillation (HP:0001663)3.47501507
16Exercise-induced myalgia (HP:0003738)3.43533830
17Clumsiness (HP:0002312)3.40829142
18Pancreatic fibrosis (HP:0100732)3.35957779
19Absence seizures (HP:0002121)3.35488990
20Impaired vibration sensation in the lower limbs (HP:0002166)3.34009510
21Generalized tonic-clonic seizures (HP:0002069)3.32920422
22Postural instability (HP:0002172)3.31722701
23Sudden death (HP:0001699)3.24976317
24True hermaphroditism (HP:0010459)3.21062698
25Protruding tongue (HP:0010808)3.19971608
26Depression (HP:0000716)3.18815528
27Poor eye contact (HP:0000817)3.18526322
28Abnormality of the lower motor neuron (HP:0002366)3.18487765
29Dysdiadochokinesis (HP:0002075)3.17195151
30Impaired social interactions (HP:0000735)3.17062401
31Abnormal social behavior (HP:0012433)3.17062401
32Hemiplegia (HP:0002301)3.09638189
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.07735308
34Ankle clonus (HP:0011448)3.04174644
35Dialeptic seizures (HP:0011146)3.02294631
36Abnormality of midbrain morphology (HP:0002418)2.96408778
37Molar tooth sign on MRI (HP:0002419)2.96408778
38Broad-based gait (HP:0002136)2.95511013
39Annular pancreas (HP:0001734)2.94531099
40Gaze-evoked nystagmus (HP:0000640)2.92055158
41Type II lissencephaly (HP:0007260)2.88122210
42Attenuation of retinal blood vessels (HP:0007843)2.86686198
43Nephronophthisis (HP:0000090)2.86653432
44Exercise-induced muscle cramps (HP:0003710)2.85528288
45Papilledema (HP:0001085)2.81718289
46Genetic anticipation (HP:0003743)2.79746750
47Supranuclear gaze palsy (HP:0000605)2.78658687
48Chronic hepatic failure (HP:0100626)2.75934742
49Abnormality of alanine metabolism (HP:0010916)2.75783357
50Hyperalaninemia (HP:0003348)2.75783357
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.75783357
52Truncal ataxia (HP:0002078)2.74071450
53Cystic liver disease (HP:0006706)2.72580469
54Dysmetria (HP:0001310)2.70645228
55Urinary urgency (HP:0000012)2.69213239
56Abnormal eating behavior (HP:0100738)2.68581800
57Decreased central vision (HP:0007663)2.67870149
58Difficulty running (HP:0009046)2.67443871
59Polydipsia (HP:0001959)2.66837224
60Abnormal drinking behavior (HP:0030082)2.66837224
61Abnormality of the renal cortex (HP:0011035)2.65855414
62Inability to walk (HP:0002540)2.64415417
63Abolished electroretinogram (ERG) (HP:0000550)2.64136504
64Abnormality of the renal medulla (HP:0100957)2.58657934
65Resting tremor (HP:0002322)2.54547513
66Anxiety (HP:0000739)2.49297852
67Abnormal EKG (HP:0003115)2.49199783
68Syncope (HP:0001279)2.47302085
69Impaired smooth pursuit (HP:0007772)2.47067796
70Heart block (HP:0012722)2.46564607
71Absent speech (HP:0001344)2.45933425
72Congenital sensorineural hearing impairment (HP:0008527)2.45699253
73Increased neuronal autofluorescent lipopigment (HP:0002074)2.44286377
74Atrial fibrillation (HP:0005110)2.43894729
75Prolonged QT interval (HP:0001657)2.43197734
76Myotonia (HP:0002486)2.40813309
77Primary atrial arrhythmia (HP:0001692)2.39149751
78Bradykinesia (HP:0002067)2.38867594
79Status epilepticus (HP:0002133)2.35507098
80Decreased circulating renin level (HP:0003351)2.35195845
81Aplasia/Hypoplasia of the tibia (HP:0005772)2.33889103
82Calf muscle hypertrophy (HP:0008981)2.32596911
83Pointed chin (HP:0000307)2.32225138
84Keratoconus (HP:0000563)2.31767465
85Increased corneal curvature (HP:0100692)2.31767465
86Impaired vibratory sensation (HP:0002495)2.29754967
87Large for gestational age (HP:0001520)2.29731788
88Myoglobinuria (HP:0002913)2.24649328
89Torticollis (HP:0000473)2.24405681
90Supraventricular tachycardia (HP:0004755)2.22468140
91Tubular atrophy (HP:0000092)2.22392783
92Abnormal atrioventricular conduction (HP:0005150)2.22319836
93Amblyopia (HP:0000646)2.21732035
94Hyporeflexia of lower limbs (HP:0002600)2.19891157
95Supraventricular arrhythmia (HP:0005115)2.19779250
96Ventricular arrhythmia (HP:0004308)2.18493475
97Atrioventricular block (HP:0001678)2.18393667
98Intention tremor (HP:0002080)2.18043188
99Abnormality of ocular smooth pursuit (HP:0000617)2.17145308
100Muscle hypertrophy of the lower extremities (HP:0008968)2.16867189
101Furrowed tongue (HP:0000221)2.15966823
102Fair hair (HP:0002286)2.15478771
103Birth length less than 3rd percentile (HP:0003561)2.14816524
104Bony spicule pigmentary retinopathy (HP:0007737)2.14174940
105Rapidly progressive (HP:0003678)2.13659479
106Lower limb amyotrophy (HP:0007210)2.11965813
107Focal dystonia (HP:0004373)2.11090368
108Lower limb asymmetry (HP:0100559)2.10941016
109Mutism (HP:0002300)2.10327845
110Absent/shortened dynein arms (HP:0200106)2.09436859
111Dynein arm defect of respiratory motile cilia (HP:0012255)2.09436859
112Stereotypic behavior (HP:0000733)2.09043712
113Sclerocornea (HP:0000647)2.08164962
114Hypoplastic ischia (HP:0003175)2.05912568
115Cerebellar dysplasia (HP:0007033)2.04983440
116Medial flaring of the eyebrow (HP:0010747)2.04318028
117Increased variability in muscle fiber diameter (HP:0003557)2.03281095
118Bulbous nose (HP:0000414)2.02008431
119Abnormality of the calf musculature (HP:0001430)2.01241049
120Spastic gait (HP:0002064)2.00935460
121Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97436482
122Lower limb muscle weakness (HP:0007340)1.96535738
123Polyuria (HP:0000103)1.94963883
124Abnormality of the periventricular white matter (HP:0002518)1.94760050
125Insomnia (HP:0100785)1.94688646
126Epileptiform EEG discharges (HP:0011182)1.94009007
127Progressive inability to walk (HP:0002505)1.93814962
128Scanning speech (HP:0002168)1.92725896
129Achilles tendon contracture (HP:0001771)1.91539825
130Upper limb amyotrophy (HP:0009129)1.91122298
131Distal upper limb amyotrophy (HP:0007149)1.91122298
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.90100423
133Abnormality of the ischium (HP:0003174)1.88041880
134Obstructive sleep apnea (HP:0002870)1.87927415
135Drooling (HP:0002307)1.87725013
136Patellar aplasia (HP:0006443)1.87537403
137Hyperventilation (HP:0002883)1.87525181
138Pheochromocytoma (HP:0002666)1.87091062
139EMG: myopathic abnormalities (HP:0003458)1.86047888
140Difficulty climbing stairs (HP:0003551)1.84941147
141Congenital hepatic fibrosis (HP:0002612)1.84460301
142Congenital, generalized hypertrichosis (HP:0004540)1.83966565
143Termporal pattern (HP:0011008)1.83029887
144Insidious onset (HP:0003587)1.83029887
145Generalized hypopigmentation of hair (HP:0011358)1.82500542
146Hemiparesis (HP:0001269)1.82028224
147Rigidity (HP:0002063)1.81942975
148Lissencephaly (HP:0001339)1.81902145
149Aplasia/Hypoplasia of the patella (HP:0006498)1.81148313
150Craniofacial dystonia (HP:0012179)1.80887672
151Abnormality of binocular vision (HP:0011514)1.80421353
152Diplopia (HP:0000651)1.80421353
153Abnormality of saccadic eye movements (HP:0000570)1.80418753
154Retinal dysplasia (HP:0007973)1.80352105
155Central scotoma (HP:0000603)1.79234996
156Muscle fiber splitting (HP:0003555)1.78338583
157Incomplete penetrance (HP:0003829)1.78232442
158Widely spaced teeth (HP:0000687)1.76731660
159Gait imbalance (HP:0002141)1.76315233
160Male pseudohermaphroditism (HP:0000037)1.75912101
161Abnormal ciliary motility (HP:0012262)1.75770084
162EEG with generalized epileptiform discharges (HP:0011198)1.75597889
163Agitation (HP:0000713)1.75322893
164Optic nerve hypoplasia (HP:0000609)1.71347564
165Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.70760097
166Hypsarrhythmia (HP:0002521)1.69653573
167Increased cerebral lipofuscin (HP:0011813)1.66995963
168Aplasia/Hypoplasia of the tongue (HP:0010295)1.65184710
169Chorioretinal atrophy (HP:0000533)1.64553224
170Anencephaly (HP:0002323)1.62763417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.82857487
2NTRK33.82736209
3MAP3K93.81451158
4EPHA43.76684884
5DAPK22.96038334
6PRKD32.82741687
7ADRBK22.68786480
8INSRR2.67757105
9BMPR1B2.64953634
10KSR22.60239724
11PAK62.46969004
12CAMKK12.44285184
13ACVR1B2.35377383
14MAP3K42.35317000
15MINK12.17499029
16TRIB32.08757062
17STK381.93762713
18MAP2K41.86575284
19GRK11.83036176
20CASK1.82748854
21MAP3K131.70756415
22TAOK11.70683600
23RIPK11.65715073
24DAPK11.64422166
25NEK11.64077926
26PHKG21.58214185
27PHKG11.58214185
28NTRK21.56266105
29KSR11.54403221
30MARK11.50291033
31CAMKK21.47270883
32NTRK11.47029716
33TAOK31.42937256
34TLK11.41630151
35PINK11.41445847
36PKN21.38743292
37ZAK1.35658792
38MAP2K71.35080143
39TNIK1.34711633
40WNK41.33632287
41WNK31.32471079
42ADRBK11.31788693
43PRPF4B1.30938578
44TYRO31.29641208
45CDK51.29155408
46AKT31.28319126
47RIPK41.24994544
48PRKCH1.24864108
49ALK1.24626853
50MAP3K21.20003722
51LMTK21.17185727
52SGK31.16465590
53OXSR11.14857877
54DMPK1.09762804
55MAP3K71.08934143
56CDK191.07930929
57PDK11.07197688
58GRK51.06855049
59STK111.05620759
60LATS21.05020205
61CAMK11.01862887
62MKNK20.99075134
63PDPK10.98574087
64RET0.97990631
65ARAF0.96995562
66FES0.95852997
67TTN0.95833667
68SGK20.95069529
69NUAK10.94259528
70MAP3K120.93480812
71SGK2230.91442472
72SGK4940.91442472
73PIK3CA0.89964674
74CAMK1G0.89359881
75SIK20.89129851
76STK390.88201512
77PKN10.87502035
78RAF10.87047973
79PRKCG0.86837097
80MAP4K20.85777937
81PDK30.85154259
82PDK40.85154259
83SCYL20.84429017
84PLK20.83790780
85PIK3CG0.81826927
86MAPKAPK30.81593085
87PTK2B0.80896405
88TIE10.79595945
89MAP2K60.79502851
90MAP3K10.79289068
91SGK10.77192491
92PRKAA20.73048248
93PRKCE0.72750126
94CDC42BPA0.72502832
95WNK10.70862389
96CAMK40.69566125
97TGFBR10.67179182
98TEC0.66555249
99PDGFRA0.66322013
100PAK30.65768313
101STK38L0.64525465
102UHMK10.64168445
103CDK150.63975243
104CDK180.63381523
105CAMK2A0.63235844
106RPS6KA30.60978020
107CAMK1D0.59893874
108CDK140.57584917
109MAPK120.56821798
110TNK20.56722511
111TXK0.56470700
112MARK20.56056737
113FGFR20.55957759
114CDK11A0.53954099
115ERBB20.53408501
116BRSK10.53120416
117OBSCN0.52594816
118STK30.50205987
119DAPK30.50016941
120PRKACA0.49544908
121MUSK0.48326935
122DYRK1A0.47313515
123TRPM70.46094929
124MAPKAPK50.45755203
125BMX0.45698656
126MAPK100.44594803
127PRKD10.44360972
128PRKCA0.42778879
129PRKAA10.42659705
130PRKG10.42428622
131PNCK0.42295582
132PRKCZ0.42083574
133MAPK150.41985930
134CAMK2D0.40976304
135PDK20.40158368
136RPS6KA60.40030462
137MAP2K10.39826217
138KIT0.39309628
139ICK0.37355244
140CSNK1D0.35866718
141MAPK130.35132765
142PRKD20.34944034
143CSNK1A10.33512803
144RPS6KA20.32833049
145PRKACG0.31319825
146SYK0.31074060
147MELK0.30783095
148CAMK2B0.30583369
149FYN0.29301062

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.87113428
2Olfactory transduction_Homo sapiens_hsa047402.76742479
3Nicotine addiction_Homo sapiens_hsa050332.51923480
4Long-term potentiation_Homo sapiens_hsa047202.42907333
5Circadian entrainment_Homo sapiens_hsa047132.31016436
6GABAergic synapse_Homo sapiens_hsa047272.23067940
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22108309
8Nitrogen metabolism_Homo sapiens_hsa009102.16095328
9Glutamatergic synapse_Homo sapiens_hsa047242.11516474
10Morphine addiction_Homo sapiens_hsa050322.09710111
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.07146060
12Amphetamine addiction_Homo sapiens_hsa050312.02957186
13Linoleic acid metabolism_Homo sapiens_hsa005911.91441974
14Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91108991
15Salivary secretion_Homo sapiens_hsa049701.87062902
16Insulin secretion_Homo sapiens_hsa049111.86922874
17Gastric acid secretion_Homo sapiens_hsa049711.83425635
18Dopaminergic synapse_Homo sapiens_hsa047281.82575681
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81659681
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80359736
21Oxytocin signaling pathway_Homo sapiens_hsa049211.69691912
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67941830
23Butanoate metabolism_Homo sapiens_hsa006501.67823338
24ABC transporters_Homo sapiens_hsa020101.67751560
25Cholinergic synapse_Homo sapiens_hsa047251.67671428
26Tryptophan metabolism_Homo sapiens_hsa003801.66481528
27Renin secretion_Homo sapiens_hsa049241.54748904
28Type II diabetes mellitus_Homo sapiens_hsa049301.52566005
29Calcium signaling pathway_Homo sapiens_hsa040201.49749378
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.47613050
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44405022
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42559307
33GnRH signaling pathway_Homo sapiens_hsa049121.37143453
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36204556
35Dilated cardiomyopathy_Homo sapiens_hsa054141.35606361
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32682816
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31604247
38Long-term depression_Homo sapiens_hsa047301.30613047
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.30563128
40cAMP signaling pathway_Homo sapiens_hsa040241.28282207
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24779769
42Cocaine addiction_Homo sapiens_hsa050301.22804794
43Glioma_Homo sapiens_hsa052141.22552620
44Ether lipid metabolism_Homo sapiens_hsa005651.21606940
45Ovarian steroidogenesis_Homo sapiens_hsa049131.20747646
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19742930
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18819242
48Taste transduction_Homo sapiens_hsa047421.15777399
49Estrogen signaling pathway_Homo sapiens_hsa049151.13911204
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13669654
51Glycerolipid metabolism_Homo sapiens_hsa005611.12985047
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12833380
53Gap junction_Homo sapiens_hsa045401.12447194
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.09688720
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06982355
56Histidine metabolism_Homo sapiens_hsa003401.05859940
57Cardiac muscle contraction_Homo sapiens_hsa042601.05567457
58mTOR signaling pathway_Homo sapiens_hsa041501.03645292
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.99164446
60Caffeine metabolism_Homo sapiens_hsa002320.98745344
61Glucagon signaling pathway_Homo sapiens_hsa049220.98200868
62Serotonergic synapse_Homo sapiens_hsa047260.96877773
63Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92353982
64Selenocompound metabolism_Homo sapiens_hsa004500.91816368
65Dorso-ventral axis formation_Homo sapiens_hsa043200.91762509
66Oocyte meiosis_Homo sapiens_hsa041140.88743297
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.88013845
68Insulin signaling pathway_Homo sapiens_hsa049100.87378298
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.86963557
70ErbB signaling pathway_Homo sapiens_hsa040120.85788524
71VEGF signaling pathway_Homo sapiens_hsa043700.85363523
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84336168
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83397788
74Melanogenesis_Homo sapiens_hsa049160.82902625
75Collecting duct acid secretion_Homo sapiens_hsa049660.82125066
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81428829
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.81156488
78Pancreatic secretion_Homo sapiens_hsa049720.80423655
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80144555
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78435192
81Arginine biosynthesis_Homo sapiens_hsa002200.76899715
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75884263
83beta-Alanine metabolism_Homo sapiens_hsa004100.75644645
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75087643
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73464811
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72815379
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71038043
88MAPK signaling pathway_Homo sapiens_hsa040100.70109845
89Arachidonic acid metabolism_Homo sapiens_hsa005900.69432345
90Bile secretion_Homo sapiens_hsa049760.68958231
91Lysine degradation_Homo sapiens_hsa003100.68631052
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67468354
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.66670956
94Thyroid hormone synthesis_Homo sapiens_hsa049180.66496569
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66319067
96Homologous recombination_Homo sapiens_hsa034400.65278922
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64874707
98Choline metabolism in cancer_Homo sapiens_hsa052310.64397123
99Non-small cell lung cancer_Homo sapiens_hsa052230.61222109
100Chemical carcinogenesis_Homo sapiens_hsa052040.61103627
101Insulin resistance_Homo sapiens_hsa049310.60170742
102Retinol metabolism_Homo sapiens_hsa008300.58669947
103Rap1 signaling pathway_Homo sapiens_hsa040150.58447159
104Inositol phosphate metabolism_Homo sapiens_hsa005620.57858641
105AMPK signaling pathway_Homo sapiens_hsa041520.57682595
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57254458
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55797515
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.55271307
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55214316
110Fatty acid biosynthesis_Homo sapiens_hsa000610.54504898
111Endocytosis_Homo sapiens_hsa041440.54092095
112Circadian rhythm_Homo sapiens_hsa047100.52005174
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.51968718
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50091180
115Endometrial cancer_Homo sapiens_hsa052130.48817894
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48505194
117HIF-1 signaling pathway_Homo sapiens_hsa040660.48369767
118Phototransduction_Homo sapiens_hsa047440.48027454
119Axon guidance_Homo sapiens_hsa043600.46815273
120Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45642352
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.44844754
122Renal cell carcinoma_Homo sapiens_hsa052110.44274201
123Ras signaling pathway_Homo sapiens_hsa040140.44223964
124Platelet activation_Homo sapiens_hsa046110.43288524
125Vibrio cholerae infection_Homo sapiens_hsa051100.42959884
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42698180
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41983669
128Chemokine signaling pathway_Homo sapiens_hsa040620.41169306
129Prion diseases_Homo sapiens_hsa050200.40910000
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40284760
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39751025
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36623014
133Prolactin signaling pathway_Homo sapiens_hsa049170.34849296
134Melanoma_Homo sapiens_hsa052180.34362543
135Mineral absorption_Homo sapiens_hsa049780.31790444
136Fanconi anemia pathway_Homo sapiens_hsa034600.31108424
137Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29470087
138Fat digestion and absorption_Homo sapiens_hsa049750.28126160
139Arginine and proline metabolism_Homo sapiens_hsa003300.25522454

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