TTC8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is involved in the formation of cilia. A mutation in this gene has also been implicated in nonsyndromic retinitis pigmentosa. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)4.72399476
2water-soluble vitamin biosynthetic process (GO:0042364)4.60625869
3intraciliary transport (GO:0042073)4.59627033
4rhodopsin mediated signaling pathway (GO:0016056)4.52206754
5retinal rod cell development (GO:0046548)4.44436379
6photoreceptor cell maintenance (GO:0045494)4.34211594
7photoreceptor cell development (GO:0042461)4.22155593
8axoneme assembly (GO:0035082)4.15478156
9eye photoreceptor cell development (GO:0042462)4.03307316
10ER overload response (GO:0006983)3.94557139
11cellular ketone body metabolic process (GO:0046950)3.90624150
12Golgi transport vesicle coating (GO:0048200)3.86619968
13COPI coating of Golgi vesicle (GO:0048205)3.86619968
14detection of calcium ion (GO:0005513)3.77926981
15synaptic vesicle exocytosis (GO:0016079)3.74600424
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68163333
17retinal cone cell development (GO:0046549)3.67817980
18regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.60647750
19ketone body metabolic process (GO:1902224)3.50034340
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.49690526
21detection of light stimulus involved in sensory perception (GO:0050962)3.48493188
22detection of light stimulus involved in visual perception (GO:0050908)3.48493188
23behavioral response to nicotine (GO:0035095)3.48019267
24dopamine transport (GO:0015872)3.31386253
25respiratory chain complex IV assembly (GO:0008535)3.30626055
26regulation of type B pancreatic cell apoptotic process (GO:2000674)3.28309934
27regulation of synaptic vesicle exocytosis (GO:2000300)3.25935224
28innervation (GO:0060384)3.25139641
29cilium movement (GO:0003341)3.24668484
30neuron cell-cell adhesion (GO:0007158)3.19078023
31inositol phosphate catabolic process (GO:0071545)3.18980444
32GMP metabolic process (GO:0046037)3.14939471
33protein localization to cilium (GO:0061512)3.12596313
34female mating behavior (GO:0060180)3.11014440
35synaptic vesicle docking involved in exocytosis (GO:0016081)3.03949200
36phosphorylated carbohydrate dephosphorylation (GO:0046838)3.02339863
37inositol phosphate dephosphorylation (GO:0046855)3.02339863
38postsynaptic membrane organization (GO:0001941)3.00903939
39vocalization behavior (GO:0071625)2.99413366
40protein localization to synapse (GO:0035418)2.98875024
41presynaptic membrane assembly (GO:0097105)2.98604977
42synaptic vesicle endocytosis (GO:0048488)2.97573086
43synaptic vesicle maturation (GO:0016188)2.97461034
44regulation of hexokinase activity (GO:1903299)2.95920237
45regulation of glucokinase activity (GO:0033131)2.95920237
46startle response (GO:0001964)2.93568124
47striatum development (GO:0021756)2.91981193
48kidney morphogenesis (GO:0060993)2.91665089
49regulation of synaptic vesicle transport (GO:1902803)2.87175549
50* cilium assembly (GO:0042384)2.87024450
51neuron-neuron synaptic transmission (GO:0007270)2.86969871
52* cilium organization (GO:0044782)2.86885301
53glutamate secretion (GO:0014047)2.86638047
54cilium morphogenesis (GO:0060271)2.86041215
55* nonmotile primary cilium assembly (GO:0035058)2.85672673
56synaptic transmission, glutamatergic (GO:0035249)2.85046000
57insulin secretion (GO:0030073)2.83636192
58regulation of cilium movement (GO:0003352)2.83269780
59branched-chain amino acid catabolic process (GO:0009083)2.83056253
60cytochrome complex assembly (GO:0017004)2.81995866
61signal peptide processing (GO:0006465)2.81575905
62epithelial cell fate commitment (GO:0072148)2.79729352
63regulation of vesicle fusion (GO:0031338)2.79638401
64epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79196771
65toxin metabolic process (GO:0009404)2.78637425
66long-term synaptic potentiation (GO:0060291)2.78450426
67peptidyl-histidine modification (GO:0018202)2.76280594
68positive regulation of meiosis (GO:0045836)2.72325979
69epithelial cilium movement (GO:0003351)2.72267596
70protein complex biogenesis (GO:0070271)2.72204154
71gamma-aminobutyric acid signaling pathway (GO:0007214)2.70515639
72mannosylation (GO:0097502)2.69788440
73regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.69373929
74regulation of female receptivity (GO:0045924)2.69123866
75negative regulation of cAMP-mediated signaling (GO:0043951)2.68969431
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68751479
77pharyngeal system development (GO:0060037)2.68464508
78preassembly of GPI anchor in ER membrane (GO:0016254)2.65669499
79glycerophospholipid catabolic process (GO:0046475)2.64123825
80detection of visible light (GO:0009584)2.63698711
81protein prenylation (GO:0018342)2.63170490
82prenylation (GO:0097354)2.63170490
83L-fucose catabolic process (GO:0042355)2.63070804
84fucose catabolic process (GO:0019317)2.63070804
85L-fucose metabolic process (GO:0042354)2.63070804
86sequestering of extracellular ligand from receptor (GO:0035581)2.62141279
87positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.61234290
88nitric oxide mediated signal transduction (GO:0007263)2.60857005
89sensory perception of light stimulus (GO:0050953)2.60439178
90regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.60357302
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.60357302
92behavioral response to cocaine (GO:0048148)2.60037966
93visual perception (GO:0007601)2.60003987
94detection of light stimulus (GO:0009583)2.59685168
95phototransduction (GO:0007602)2.57319466
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56640251
97presynaptic membrane organization (GO:0097090)2.56414909
98estrogen biosynthetic process (GO:0006703)2.56144072
99lactate metabolic process (GO:0006089)2.55134252
100axonemal dynein complex assembly (GO:0070286)2.53802399
101C-terminal protein amino acid modification (GO:0018410)2.53258202
102regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.51763862
103cornea development in camera-type eye (GO:0061303)2.50540212
104C-terminal protein lipidation (GO:0006501)2.50354563
105regulation of neurotransmitter uptake (GO:0051580)2.50198683
106retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.50052073
107mitochondrial respiratory chain complex assembly (GO:0033108)2.49826319
108aldehyde catabolic process (GO:0046185)2.49795590
109catecholamine transport (GO:0051937)2.49460067
110polyol catabolic process (GO:0046174)2.49204054
111establishment of synaptic vesicle localization (GO:0097480)2.48960852
112synaptic vesicle transport (GO:0048489)2.48960852
113somite development (GO:0061053)2.48851907
114phototransduction, visible light (GO:0007603)2.48604644
115dorsal/ventral axis specification (GO:0009950)2.48121185
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.47378263
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46747023
118positive regulation of insulin secretion (GO:0032024)2.45519463
119neurotransmitter-gated ion channel clustering (GO:0072578)2.45411214
120positive regulation of meiotic cell cycle (GO:0051446)2.43738791
121nephron tubule morphogenesis (GO:0072078)2.43254536
122nephron epithelium morphogenesis (GO:0072088)2.43254536
123neurotransmitter secretion (GO:0007269)2.42886210
124endocrine pancreas development (GO:0031018)2.41770539
125glandular epithelial cell differentiation (GO:0002067)2.41710089
126synaptic transmission, dopaminergic (GO:0001963)2.40419963
127neuron fate determination (GO:0048664)2.39579775
128* photoreceptor cell differentiation (GO:0046530)2.39240246
129* eye photoreceptor cell differentiation (GO:0001754)2.39240246
130reflex (GO:0060004)2.38629648
131apical protein localization (GO:0045176)2.38471286
132regulation of insulin secretion (GO:0050796)2.38071962
133auditory receptor cell differentiation (GO:0042491)2.37130729
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.36716577
135regulation of neurotransmitter secretion (GO:0046928)2.35900041
136response to pheromone (GO:0019236)2.35324757
137smoothened signaling pathway (GO:0007224)2.35178332
138glutamate receptor signaling pathway (GO:0007215)2.34225064
139mechanosensory behavior (GO:0007638)2.33782020
140intra-Golgi vesicle-mediated transport (GO:0006891)2.33314166
141substrate-independent telencephalic tangential migration (GO:0021826)2.32621843
142substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.32621843
143neuron recognition (GO:0008038)2.31733025
144retinal ganglion cell axon guidance (GO:0031290)2.31042121
145ionotropic glutamate receptor signaling pathway (GO:0035235)2.30925575
146cilium or flagellum-dependent cell motility (GO:0001539)2.30905107
147lipid particle organization (GO:0034389)2.30825136
148* cellular component assembly involved in morphogenesis (GO:0010927)2.30157599
149neuron fate specification (GO:0048665)2.29567176
150astrocyte differentiation (GO:0048708)2.28874630
151spinal cord motor neuron differentiation (GO:0021522)2.28716699
152regulation of cardioblast proliferation (GO:0003264)2.22793581
153regulation of secondary heart field cardioblast proliferation (GO:0003266)2.22793581
154GPI anchor metabolic process (GO:0006505)2.21642453
155ubiquinone metabolic process (GO:0006743)2.20743707
156platelet dense granule organization (GO:0060155)2.20419138
157regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.19467119
158positive regulation of peptide hormone secretion (GO:0090277)2.19333454
159positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.17889094
160indolalkylamine metabolic process (GO:0006586)2.17356434
161pteridine-containing compound biosynthetic process (GO:0042559)2.15660532
162adaptation of signaling pathway (GO:0023058)2.15352247
163peptidyl-cysteine modification (GO:0018198)2.15142149
164signal transduction involved in regulation of gene expression (GO:0023019)2.13998729
165vitamin biosynthetic process (GO:0009110)2.13202453
166positive regulation of peptide secretion (GO:0002793)2.12798034
167cardiac right ventricle morphogenesis (GO:0003215)2.12083204
168behavioral response to ethanol (GO:0048149)2.11699894
169piRNA metabolic process (GO:0034587)2.11586731
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.11028211
171NADH dehydrogenase complex assembly (GO:0010257)2.11028211

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.15811465
2GBX2_23144817_ChIP-Seq_PC3_Human4.01129559
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75892298
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.01166405
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43601131
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.38797715
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29322191
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.17707882
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.17248296
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17229120
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.15275162
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.12115441
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08597055
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06373918
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04779134
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98317898
17CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97576023
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.97417582
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.97417582
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96953049
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94712727
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92966720
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92370699
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.92169558
25REST_21632747_ChIP-Seq_MESCs_Mouse1.90623344
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89860449
27GABP_17652178_ChIP-ChIP_JURKAT_Human1.87721451
28SMAD4_21799915_ChIP-Seq_A2780_Human1.85453064
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.84100930
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83637709
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.83472773
32* PIAS1_25552417_ChIP-Seq_VCAP_Human1.82392491
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80426732
34P300_19829295_ChIP-Seq_ESCs_Human1.75993962
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74457856
36DROSHA_22980978_ChIP-Seq_HELA_Human1.73211612
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68886497
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.68094190
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66998549
40IGF1R_20145208_ChIP-Seq_DFB_Human1.66615260
41TAF15_26573619_Chip-Seq_HEK293_Human1.65222771
42* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.62354381
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59693779
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.58801263
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53756093
46ELK1_19687146_ChIP-ChIP_HELA_Human1.53036873
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.52719530
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52703243
49FUS_26573619_Chip-Seq_HEK293_Human1.52493567
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51199135
51* REST_18959480_ChIP-ChIP_MESCs_Mouse1.50226068
52STAT3_23295773_ChIP-Seq_U87_Human1.49150543
53RNF2_27304074_Chip-Seq_NSC_Mouse1.46581397
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44235913
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43618462
56VDR_22108803_ChIP-Seq_LS180_Human1.42811382
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42740813
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.41727866
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.41394602
60ER_23166858_ChIP-Seq_MCF-7_Human1.41278569
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40808657
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38828570
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38118892
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.37292962
65TP53_22573176_ChIP-Seq_HFKS_Human1.36864910
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36420507
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35231726
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35145111
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.34276661
70* AR_25329375_ChIP-Seq_VCAP_Human1.34095080
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34036687
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.31626167
73* RARB_27405468_Chip-Seq_BRAIN_Mouse1.31130184
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.28966434
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26889757
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26243193
77* TCF4_23295773_ChIP-Seq_U87_Human1.25390286
78EWS_26573619_Chip-Seq_HEK293_Human1.25341369
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25091408
80RUNX2_22187159_ChIP-Seq_PCA_Human1.23427232
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.23111776
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22850994
83ZNF274_21170338_ChIP-Seq_K562_Hela1.20928935
84PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19900059
85* TCF4_22108803_ChIP-Seq_LS180_Human1.19690497
86BCAT_22108803_ChIP-Seq_LS180_Human1.17640743
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17557199
88SOX2_19829295_ChIP-Seq_ESCs_Human1.17196075
89NANOG_19829295_ChIP-Seq_ESCs_Human1.17196075
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.16403330
91HTT_18923047_ChIP-ChIP_STHdh_Human1.15029510
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14837631
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14625655
94SMAD_19615063_ChIP-ChIP_OVARY_Human1.14489378
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13806134
96CDX2_22108803_ChIP-Seq_LS180_Human1.13347587
97LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13086730
98* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12495788
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12336915
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.11269962
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10276782
102FOXA1_25329375_ChIP-Seq_VCAP_Human1.10023925
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10023925
104SOX9_26525672_Chip-Seq_HEART_Mouse1.08381658
105* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07672256
106* AR_19668381_ChIP-Seq_PC3_Human1.07284021
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.07147631
108MYC_18940864_ChIP-ChIP_HL60_Human1.07111323
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06642715
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.06636720
111P53_22387025_ChIP-Seq_ESCs_Mouse1.06602078
112CBP_20019798_ChIP-Seq_JUKART_Human1.06436782
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06436782
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05956471
115AR_20517297_ChIP-Seq_VCAP_Human1.05118778
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05034956
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.04749429
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04197131
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03519947
120CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03497698
121SRF_21415370_ChIP-Seq_HL-1_Mouse1.03022776
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02766106
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02630385
124CRX_20693478_ChIP-Seq_RETINA_Mouse1.02037902
125* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01934425
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01775291
127SOX2_18555785_Chip-Seq_ESCs_Mouse1.01607685
128RING1B_27294783_Chip-Seq_NPCs_Mouse1.00957536
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.00587786
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.99853329
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98288706
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98252242
133* ARNT_22903824_ChIP-Seq_MCF-7_Human0.97545890
134NCOR_22424771_ChIP-Seq_293T_Human0.97459632
135JUN_21703547_ChIP-Seq_K562_Human0.97234985
136P300_18555785_Chip-Seq_ESCs_Mouse0.97198094
137* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96265888
138SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96175928
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94677119
140* FLI1_21867929_ChIP-Seq_TH2_Mouse0.94492522
141PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94408255
142CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93806278

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog3.64078438
2MP0006072_abnormal_retinal_apoptosis3.14779799
3MP0010386_abnormal_urinary_bladder3.14342925
4MP0004859_abnormal_synaptic_plasticity2.59930706
5MP0005646_abnormal_pituitary_gland2.53541669
6MP0005253_abnormal_eye_physiology2.46625699
7MP0002638_abnormal_pupillary_reflex2.41963380
8MP0009780_abnormal_chondrocyte_physiolo2.38869439
9MP0003880_abnormal_central_pattern2.32824191
10MP0002938_white_spotting2.24449320
11MP0001984_abnormal_olfaction2.24149920
12MP0002909_abnormal_adrenal_gland2.22641035
13MP0003122_maternal_imprinting2.14556251
14MP0004270_analgesia2.13126126
15MP0005645_abnormal_hypothalamus_physiol2.12890634
16MP0003011_delayed_dark_adaptation2.07138996
17MP0000013_abnormal_adipose_tissue2.06203543
18MP0002102_abnormal_ear_morphology2.06004779
19MP0003635_abnormal_synaptic_transmissio2.04470146
20MP0002734_abnormal_mechanical_nocicepti2.02529819
21MP0008877_abnormal_DNA_methylation1.94135899
22MP0002876_abnormal_thyroid_physiology1.92281081
23MP0004043_abnormal_pH_regulation1.83199801
24MP0002063_abnormal_learning/memory/cond1.82305449
25MP0000631_abnormal_neuroendocrine_gland1.81754901
26MP0002163_abnormal_gland_morphology1.80756398
27MP0003183_abnormal_peptide_metabolism1.78395926
28MP0006276_abnormal_autonomic_nervous1.78315158
29MP0002272_abnormal_nervous_system1.67225939
30MP0003787_abnormal_imprinting1.66621387
31MP0002572_abnormal_emotion/affect_behav1.64061409
32MP0000678_abnormal_parathyroid_gland1.63494166
33MP0001502_abnormal_circadian_rhythm1.60965034
34MP0005379_endocrine/exocrine_gland_phen1.60081416
35MP0009745_abnormal_behavioral_response1.59033297
36MP0001188_hyperpigmentation1.54528817
37MP0005423_abnormal_somatic_nervous1.53079461
38MP0000778_abnormal_nervous_system1.52981733
39MP0000427_abnormal_hair_cycle1.52719060
40MP0005195_abnormal_posterior_eye1.48339993
41MP0001486_abnormal_startle_reflex1.48275571
42MP0002064_seizures1.48064164
43MP0002184_abnormal_innervation1.47151855
44MP0008875_abnormal_xenobiotic_pharmacok1.46590044
45MP0004147_increased_porphyrin_level1.43453390
46MP0000049_abnormal_middle_ear1.43118254
47MP0002557_abnormal_social/conspecific_i1.42542799
48MP0001986_abnormal_taste_sensitivity1.40043657
49MP0001177_atelectasis1.38831985
50MP0002653_abnormal_ependyma_morphology1.35883167
51MP0000372_irregular_coat_pigmentation1.35581518
52MP0006292_abnormal_olfactory_placode1.34650737
53MP0001501_abnormal_sleep_pattern1.34646071
54MP0003283_abnormal_digestive_organ1.33438617
55MP0002837_dystrophic_cardiac_calcinosis1.33107539
56MP0002234_abnormal_pharynx_morphology1.31912728
57MP0001944_abnormal_pancreas_morphology1.31340904
58MP0009046_muscle_twitch1.29440699
59MP0002928_abnormal_bile_duct1.29185428
60MP0001968_abnormal_touch/_nociception1.27560253
61MP0002882_abnormal_neuron_morphology1.27339109
62MP0002067_abnormal_sensory_capabilities1.24513410
63MP0008872_abnormal_physiological_respon1.22761798
64MP0002877_abnormal_melanocyte_morpholog1.20379608
65MP0001485_abnormal_pinna_reflex1.19728207
66MP0002229_neurodegeneration1.18909616
67MP0002752_abnormal_somatic_nervous1.18869968
68MP0005389_reproductive_system_phenotype1.18794178
69MP0002090_abnormal_vision1.18508314
70MP0001324_abnormal_eye_pigmentation1.17429046
71MP0000639_abnormal_adrenal_gland1.16247161
72MP0004142_abnormal_muscle_tone1.14654168
73MP0005332_abnormal_amino_acid1.12419867
74MP0003890_abnormal_embryonic-extraembry1.12047151
75MP0005084_abnormal_gallbladder_morpholo1.11754299
76MP0002733_abnormal_thermal_nociception1.11112501
77MP0001970_abnormal_pain_threshold1.10680856
78MP0001299_abnormal_eye_distance/1.10676027
79MP0004924_abnormal_behavior1.10447807
80MP0005386_behavior/neurological_phenoty1.10447807
81MP0004019_abnormal_vitamin_homeostasis1.08605856
82MP0001529_abnormal_vocalization1.08459184
83MP0003195_calcinosis1.07987161
84MP0003121_genomic_imprinting1.07222215
85MP0002736_abnormal_nociception_after1.06662152
86MP0010234_abnormal_vibrissa_follicle1.06414209
87MP0002693_abnormal_pancreas_physiology1.06362761
88MP0005220_abnormal_exocrine_pancreas1.06236262
89MP0010678_abnormal_skin_adnexa1.06100189
90MP0005391_vision/eye_phenotype1.04774604
91MP0005367_renal/urinary_system_phenotyp1.04454333
92MP0000516_abnormal_urinary_system1.04454333
93MP0001756_abnormal_urination1.04441130
94MP0010030_abnormal_orbit_morphology1.03012922
95MP0000003_abnormal_adipose_tissue1.02823032
96MP0000383_abnormal_hair_follicle1.01068299
97MP0005503_abnormal_tendon_morphology0.99535317
98MP0000647_abnormal_sebaceous_gland0.98830802
99MP0003942_abnormal_urinary_system0.98342393
100MP0003136_yellow_coat_color0.98287503
101MP0002751_abnormal_autonomic_nervous0.97914011
102MP0005248_abnormal_Harderian_gland0.96873283
103MP0008789_abnormal_olfactory_epithelium0.95873195
104MP0005394_taste/olfaction_phenotype0.92867379
105MP0005499_abnormal_olfactory_system0.92867379
106MP0004885_abnormal_endolymph0.92090584
107MP0002735_abnormal_chemical_nociception0.91868778
108MP0008995_early_reproductive_senescence0.91111229
109MP0001905_abnormal_dopamine_level0.90914812
110MP0004085_abnormal_heartbeat0.90160417
111MP0002177_abnormal_outer_ear0.89789834
112MP0000026_abnormal_inner_ear0.89069341
113MP0002078_abnormal_glucose_homeostasis0.89034132
114MP0000538_abnormal_urinary_bladder0.88920530
115MP0010329_abnormal_lipoprotein_level0.88685243
116MP0003634_abnormal_glial_cell0.88358328
117MP0005365_abnormal_bile_salt0.88088721
118MP0002254_reproductive_system_inflammat0.87470822
119MP0002896_abnormal_bone_mineralization0.86901819
120MP0000955_abnormal_spinal_cord0.86729576
121MP0003937_abnormal_limbs/digits/tail_de0.85799818
122MP0002069_abnormal_eating/drinking_beha0.85720322
123MP0001440_abnormal_grooming_behavior0.85092753
124MP0002152_abnormal_brain_morphology0.84938343
125MP0000569_abnormal_digit_pigmentation0.84928705
126MP0002160_abnormal_reproductive_system0.84618148
127MP0002295_abnormal_pulmonary_circulatio0.84400181
128MP0003959_abnormal_lean_body0.84209366
129MP0003186_abnormal_redox_activity0.84098876
130MP0004133_heterotaxia0.83890122
131MP0005187_abnormal_penis_morphology0.83732833
132MP0003786_premature_aging0.83690089
133MP0001270_distended_abdomen0.82570932
134MP0008058_abnormal_DNA_repair0.81464134
135MP0001764_abnormal_homeostasis0.81449147
136MP0002066_abnormal_motor_capabilities/c0.81324061
137MP0002233_abnormal_nose_morphology0.81279920
138MP0000462_abnormal_digestive_system0.80966083
139MP0006054_spinal_hemorrhage0.80737750
140MP0008569_lethality_at_weaning0.79613676
141MP0009697_abnormal_copulation0.79591743
142MP0000681_abnormal_thyroid_gland0.79316864
143MP0001963_abnormal_hearing_physiology0.79273189
144MP0009250_abnormal_appendicular_skeleto0.77833555

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)5.79370774
2* Abnormal rod and cone electroretinograms (HP:0008323)4.59181020
3* Bony spicule pigmentary retinopathy (HP:0007737)4.49395511
4Central scotoma (HP:0000603)4.23064222
5Abnormality of macular pigmentation (HP:0008002)4.01559868
6Absent rod-and cone-mediated responses on ERG (HP:0007688)3.97519791
7Pancreatic fibrosis (HP:0100732)3.89440460
8True hermaphroditism (HP:0010459)3.67926781
9Intestinal atresia (HP:0011100)3.67038711
10Scotoma (HP:0000575)3.64533963
11Decreased central vision (HP:0007663)3.52780470
12* Gait imbalance (HP:0002141)3.39853359
13* Congenital primary aphakia (HP:0007707)3.33171915
14Pancreatic cysts (HP:0001737)3.30930732
15Hypothermia (HP:0002045)3.25953908
16Focal motor seizures (HP:0011153)3.25247768
17* Medial flaring of the eyebrow (HP:0010747)3.24544582
18Chorioretinal atrophy (HP:0000533)3.15661496
19Large for gestational age (HP:0001520)3.14035597
20* Nephrogenic diabetes insipidus (HP:0009806)3.12145140
21Abnormality of midbrain morphology (HP:0002418)3.11471819
22Molar tooth sign on MRI (HP:0002419)3.11471819
23Occipital encephalocele (HP:0002085)3.10156506
24Abnormal respiratory motile cilium physiology (HP:0012261)3.06382202
25Hypoglycemic seizures (HP:0002173)3.00912828
26Cystic liver disease (HP:0006706)2.96169892
27Keratoconus (HP:0000563)2.95717383
28Increased corneal curvature (HP:0100692)2.95717383
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.94569026
30Bifid tongue (HP:0010297)2.92901779
31Abnormal ciliary motility (HP:0012262)2.86270226
32Rhinitis (HP:0012384)2.85316845
33* Vaginal atresia (HP:0000148)2.83176453
34* Genital tract atresia (HP:0001827)2.77815840
35Epileptic encephalopathy (HP:0200134)2.74250814
36Severe visual impairment (HP:0001141)2.74214528
37Ketoacidosis (HP:0001993)2.72954728
38* Type II diabetes mellitus (HP:0005978)2.68482673
39* Attenuation of retinal blood vessels (HP:0007843)2.66790048
40Atonic seizures (HP:0010819)2.64497167
41Febrile seizures (HP:0002373)2.59484228
42Bell-shaped thorax (HP:0001591)2.58577264
43Hypoplasia of the fovea (HP:0007750)2.53320796
44Aplasia/Hypoplasia of the fovea (HP:0008060)2.53320796
45Abnormality of the renal cortex (HP:0011035)2.50768298
46Abolished electroretinogram (ERG) (HP:0000550)2.50587412
47* Retinitis pigmentosa (HP:0000510)2.50364785
48Abnormality of the fovea (HP:0000493)2.50212340
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.47787136
50Tubular atrophy (HP:0000092)2.45616559
51Hypoglycemic coma (HP:0001325)2.41752676
52Visual hallucinations (HP:0002367)2.37283179
53Retinal dysplasia (HP:0007973)2.36965632
54Increased hepatocellular lipid droplets (HP:0006565)2.35923505
55Lipid accumulation in hepatocytes (HP:0006561)2.35493079
56Male pseudohermaphroditism (HP:0000037)2.30916843
57Acute necrotizing encephalopathy (HP:0006965)2.29448776
58Chronic hepatic failure (HP:0100626)2.29118143
59* Poor coordination (HP:0002370)2.29010790
60Progressive macrocephaly (HP:0004481)2.28382987
61Anencephaly (HP:0002323)2.27839842
62* Aplasia/Hypoplasia of the lens (HP:0008063)2.26705974
63Nephronophthisis (HP:0000090)2.24205329
64Gastrointestinal atresia (HP:0002589)2.22629210
65Mitochondrial inheritance (HP:0001427)2.21399229
66Dyschromatopsia (HP:0007641)2.20950086
67Decreased circulating renin level (HP:0003351)2.19968759
68Sclerocornea (HP:0000647)2.19450596
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.19384336
70Pigmentary retinal degeneration (HP:0001146)2.17556360
71Renal Fanconi syndrome (HP:0001994)2.16789375
72Hyperglycemia (HP:0003074)2.16634872
73Furrowed tongue (HP:0000221)2.16089873
74* Photophobia (HP:0000613)2.15337108
75Abnormality of the renal medulla (HP:0100957)2.15001943
76Acute encephalopathy (HP:0006846)2.14036572
77Polydipsia (HP:0001959)2.13123056
78Abnormal drinking behavior (HP:0030082)2.13123056
79Abnormality of aromatic amino acid family metabolism (HP:0004338)2.12863584
80Enlarged kidneys (HP:0000105)2.11414049
81Aplasia/hypoplasia of the uterus (HP:0008684)2.09674849
82Chronic bronchitis (HP:0004469)2.07221802
83Abnormality of calcium-phosphate metabolism (HP:0100530)2.05295998
84Mesangial abnormality (HP:0001966)2.04818341
85Median cleft lip (HP:0000161)2.04779332
86Pendular nystagmus (HP:0012043)2.03839025
87Papillary thyroid carcinoma (HP:0002895)2.03591327
88Increased CSF lactate (HP:0002490)1.99735033
89Gaze-evoked nystagmus (HP:0000640)1.98911140
90Abnormality of the labia minora (HP:0012880)1.97940047
91Abnormal respiratory epithelium morphology (HP:0012253)1.97459898
92Abnormal respiratory motile cilium morphology (HP:0005938)1.97459898
93* Postaxial hand polydactyly (HP:0001162)1.95767295
94Oligodactyly (hands) (HP:0001180)1.92996615
95Disproportionate short-trunk short stature (HP:0003521)1.92544590
96Epileptiform EEG discharges (HP:0011182)1.92240426
97Hemiparesis (HP:0001269)1.91941924
98Dynein arm defect of respiratory motile cilia (HP:0012255)1.91676055
99Absent/shortened dynein arms (HP:0200106)1.91676055
100Double outlet right ventricle (HP:0001719)1.91661853
101Congenital malformation of the right heart (HP:0011723)1.91661853
102Type II lissencephaly (HP:0007260)1.89918273
103Tubulointerstitial nephritis (HP:0001970)1.88044651
104EEG with generalized epileptiform discharges (HP:0011198)1.87806478
105Abnormality of renal resorption (HP:0011038)1.87712564
106Abnormal sex determination (HP:0012244)1.86770128
107Sex reversal (HP:0012245)1.86770128
108Limb dystonia (HP:0002451)1.86152340
109Abnormal mitochondria in muscle tissue (HP:0008316)1.85721924
110Hepatic necrosis (HP:0002605)1.85459341
111Focal seizures (HP:0007359)1.85190098
112Adrenal hypoplasia (HP:0000835)1.83117407
113Posterior subcapsular cataract (HP:0007787)1.82370228
114Methylmalonic acidemia (HP:0002912)1.82320567
115Aplasia/Hypoplasia of the tibia (HP:0005772)1.80321153
116Ketosis (HP:0001946)1.79906645
117Hepatoblastoma (HP:0002884)1.79601948
118Congenital hepatic fibrosis (HP:0002612)1.79357357
119Pheochromocytoma (HP:0002666)1.79058972
120Absent eyebrow (HP:0002223)1.78610079
121Progressive cerebellar ataxia (HP:0002073)1.77979480
122Hepatocellular necrosis (HP:0001404)1.77757567
123Absent eyelashes (HP:0000561)1.77717811
124Absence seizures (HP:0002121)1.77600919
125Optic disc pallor (HP:0000543)1.77347113
126Symptomatic seizures (HP:0011145)1.77095649
127Constricted visual fields (HP:0001133)1.75446046
128Abnormality of dentin (HP:0010299)1.75374033
129Hypsarrhythmia (HP:0002521)1.73849067
130Hyperventilation (HP:0002883)1.73451611
131Congenital, generalized hypertrichosis (HP:0004540)1.72945187
132Narrow forehead (HP:0000341)1.72935136
133Short tibia (HP:0005736)1.72501850
134Optic nerve hypoplasia (HP:0000609)1.71366977
135Muscular hypotonia of the trunk (HP:0008936)1.70606236
136Postaxial foot polydactyly (HP:0001830)1.69363778
137Preaxial hand polydactyly (HP:0001177)1.68858960
138Oculomotor apraxia (HP:0000657)1.68742998
139Agitation (HP:0000713)1.68418462
140Absent speech (HP:0001344)1.68020573
141Anophthalmia (HP:0000528)1.67825664
142Abnormality of urine glucose concentration (HP:0011016)1.65334851
143Glycosuria (HP:0003076)1.65334851
144Protruding tongue (HP:0010808)1.65115995
145Morphological abnormality of the middle ear (HP:0008609)1.65069138
146Congenital sensorineural hearing impairment (HP:0008527)1.64956336
147Polyuria (HP:0000103)1.64917027
148Abnormal biliary tract physiology (HP:0012439)1.64335285
149Bile duct proliferation (HP:0001408)1.64335285
150Hyperinsulinemic hypoglycemia (HP:0000825)1.62784896
151Tubulointerstitial abnormality (HP:0001969)1.61819082
152Ectopic anus (HP:0004397)1.61661996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.38930688
2CASK3.28179466
3MAP3K43.22871514
4MAP4K22.94369239
5NTRK32.69433685
6PRKD32.42748598
7MAP2K72.37765354
8FGFR22.26356075
9ERBB32.24636130
10MAPK152.16764575
11PRPF4B2.07227086
12ACVR1B1.98266454
13INSRR1.97611521
14BRAF1.86060736
15SGK21.85562746
16SGK2231.82360067
17SGK4941.82360067
18PINK11.80269416
19MAPK131.78793626
20STK391.68186638
21BMPR21.67983156
22BCR1.67782138
23SIK31.67728676
24EPHA41.67039206
25MAP3K21.66272222
26IRAK21.64437558
27PLK21.61584692
28NUAK11.61543668
29MST41.58708430
30BMPR1B1.57034955
31FRK1.53359699
32IRAK11.52044855
33MARK11.46551037
34ARAF1.46252098
35MUSK1.45395140
36ZAK1.44609061
37MINK11.44545103
38EIF2AK11.41809063
39PASK1.32468281
40CDK31.32228618
41TLK11.29258416
42EIF2AK31.28076058
43MKNK21.28001249
44CDK81.25575413
45TAF11.22616224
46GRK11.20291921
47NTRK21.18177559
48TNIK1.17131644
49WNK41.10768478
50STK161.07839412
51SGK31.07103680
52WNK31.06424371
53PRKCG1.05064025
54DYRK1A1.01768924
55PNCK1.01348966
56PRKCE1.00031701
57CAMK2D0.94873593
58CDC42BPA0.94772041
59MAP2K40.94459755
60STK30.93799722
61TRIM280.89808436
62ICK0.88069856
63MYLK0.87594871
64KSR10.86682651
65NEK60.86133513
66UHMK10.86131846
67CAMK2B0.86077526
68PAK30.84824470
69CAMK2A0.84571940
70NLK0.84403544
71CDK50.83792948
72CSNK1A1L0.83733339
73BRSK20.82456132
74CCNB10.80748092
75EPHA30.75880167
76ADRBK20.75186865
77CAMKK20.74959254
78TSSK60.74820695
79PAK60.74235176
80NTRK10.74081226
81PRKCH0.72386964
82CSNK1G20.71999157
83MAP2K60.71021697
84PHKG20.70488988
85PHKG10.70488988
86RPS6KA20.70059490
87FER0.69748361
88PLK30.69293668
89STK38L0.66586650
90PIK3CG0.66408337
91CSNK1G30.65874077
92HIPK20.64986436
93SGK10.64434760
94TGFBR10.63375948
95LIMK10.62992644
96NEK10.62989686
97NME10.62205719
98GRK50.61494830
99TRPM70.61336448
100SRPK10.59939390
101LMTK20.58170877
102YES10.57979744
103CAMK2G0.55879610
104RPS6KB10.55709483
105PRKCI0.55515316
106PTK2B0.55021109
107ADRBK10.54839209
108WEE10.53862793
109CSNK1G10.52221397
110CAMK1G0.51718808
111VRK10.50546020
112OXSR10.49856071
113MAP3K90.49358411
114PRKACA0.48854549
115DAPK20.48463663
116MKNK10.48233097
117PRKG10.48204195
118CSNK1A10.47212482
119TAOK30.46874621
120TIE10.46088502
121VRK20.45997924
122PLK10.45184626
123DYRK20.45172421
124WNK10.42958246
125PRKCB0.41152007
126MAP3K120.39883796
127PBK0.39578555
128LATS10.39301119
129NEK20.38553187
130ERBB40.37746988
131PRKD20.37465743
132CSNK1E0.35910219
133RPS6KA30.35573032
134MAPK100.35389913
135TNK20.34812453
136CDK140.34759129
137BCKDK0.34313133
138MAP2K10.32815243
139PRKAA20.32223924
140EPHB20.31915262
141CSNK1D0.31865127
142PIK3CA0.31217417
143PRKAA10.31082237
144CHUK0.30192230
145CAMK10.30005648

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.36680436
2Protein export_Homo sapiens_hsa030603.89982025
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.21526704
4Nicotine addiction_Homo sapiens_hsa050333.00806990
5Synaptic vesicle cycle_Homo sapiens_hsa047212.75456604
6Insulin secretion_Homo sapiens_hsa049112.63408045
7GABAergic synapse_Homo sapiens_hsa047272.57489032
8Olfactory transduction_Homo sapiens_hsa047402.50077228
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36088103
10Amphetamine addiction_Homo sapiens_hsa050312.31109788
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.27211899
12Circadian entrainment_Homo sapiens_hsa047132.24873832
13Morphine addiction_Homo sapiens_hsa050322.19063564
14Vibrio cholerae infection_Homo sapiens_hsa051102.07358855
15Vitamin B6 metabolism_Homo sapiens_hsa007502.07128177
16Cocaine addiction_Homo sapiens_hsa050302.06113506
17Taste transduction_Homo sapiens_hsa047422.02824017
18Serotonergic synapse_Homo sapiens_hsa047261.89186391
19Collecting duct acid secretion_Homo sapiens_hsa049661.88147203
20Propanoate metabolism_Homo sapiens_hsa006401.87072391
21Dopaminergic synapse_Homo sapiens_hsa047281.86565664
22Nitrogen metabolism_Homo sapiens_hsa009101.79474453
23Glutamatergic synapse_Homo sapiens_hsa047241.78169143
24Folate biosynthesis_Homo sapiens_hsa007901.75100414
25Cholinergic synapse_Homo sapiens_hsa047251.56195994
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.55885872
27Selenocompound metabolism_Homo sapiens_hsa004501.54652132
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.54155187
29Tryptophan metabolism_Homo sapiens_hsa003801.50690886
30Long-term potentiation_Homo sapiens_hsa047201.47711188
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46919616
32Basal transcription factors_Homo sapiens_hsa030221.45159867
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44469460
34Linoleic acid metabolism_Homo sapiens_hsa005911.44027364
35Fatty acid elongation_Homo sapiens_hsa000621.41911728
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40934375
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32787206
38Peroxisome_Homo sapiens_hsa041461.31293418
39Circadian rhythm_Homo sapiens_hsa047101.30710758
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27201059
41RNA polymerase_Homo sapiens_hsa030201.26422901
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.23204238
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20791183
44Steroid biosynthesis_Homo sapiens_hsa001001.20593560
45Caffeine metabolism_Homo sapiens_hsa002321.20405856
46Renin secretion_Homo sapiens_hsa049241.19837920
47Ether lipid metabolism_Homo sapiens_hsa005651.18668864
48N-Glycan biosynthesis_Homo sapiens_hsa005101.16697048
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13490419
50Sulfur metabolism_Homo sapiens_hsa009201.12781486
51beta-Alanine metabolism_Homo sapiens_hsa004101.12670931
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11869876
53Fatty acid degradation_Homo sapiens_hsa000711.07546423
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06375360
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03194588
56Calcium signaling pathway_Homo sapiens_hsa040201.02770467
57Pentose and glucuronate interconversions_Homo sapiens_hsa000401.02581805
58Alcoholism_Homo sapiens_hsa050340.99513350
59Chemical carcinogenesis_Homo sapiens_hsa052040.99102447
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98585135
61Type I diabetes mellitus_Homo sapiens_hsa049400.97762816
62Oxidative phosphorylation_Homo sapiens_hsa001900.97573224
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97377721
64Fatty acid metabolism_Homo sapiens_hsa012120.96610569
65cAMP signaling pathway_Homo sapiens_hsa040240.96387063
66Proteasome_Homo sapiens_hsa030500.94794694
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94577105
68One carbon pool by folate_Homo sapiens_hsa006700.94406758
69Salivary secretion_Homo sapiens_hsa049700.90083566
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89324917
71Thyroid hormone synthesis_Homo sapiens_hsa049180.88738704
72Retinol metabolism_Homo sapiens_hsa008300.87948873
73Melanogenesis_Homo sapiens_hsa049160.87888837
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.86346001
75Type II diabetes mellitus_Homo sapiens_hsa049300.86312268
76Metabolic pathways_Homo sapiens_hsa011000.86043774
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84702365
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83807822
79Long-term depression_Homo sapiens_hsa047300.83352760
80Glutathione metabolism_Homo sapiens_hsa004800.81611140
81GnRH signaling pathway_Homo sapiens_hsa049120.81097677
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80607551
83Fanconi anemia pathway_Homo sapiens_hsa034600.80098149
84RNA degradation_Homo sapiens_hsa030180.79324019
85Glucagon signaling pathway_Homo sapiens_hsa049220.78728080
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77899141
87Oxytocin signaling pathway_Homo sapiens_hsa049210.75060951
88Gap junction_Homo sapiens_hsa045400.74976208
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73264719
90ABC transporters_Homo sapiens_hsa020100.72001227
91Mineral absorption_Homo sapiens_hsa049780.70859424
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70283719
93Alzheimers disease_Homo sapiens_hsa050100.70078876
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.69023630
95Homologous recombination_Homo sapiens_hsa034400.68501680
96Hedgehog signaling pathway_Homo sapiens_hsa043400.68111439
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67419171
98Wnt signaling pathway_Homo sapiens_hsa043100.65463239
99Basal cell carcinoma_Homo sapiens_hsa052170.65262294
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.64469549
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62783215
102Regulation of autophagy_Homo sapiens_hsa041400.62725986
103Arachidonic acid metabolism_Homo sapiens_hsa005900.61483704
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61187642
105Estrogen signaling pathway_Homo sapiens_hsa049150.60527905
106Sulfur relay system_Homo sapiens_hsa041220.59322288
107Huntingtons disease_Homo sapiens_hsa050160.59039353
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58806992
109Gastric acid secretion_Homo sapiens_hsa049710.58641069
110Cardiac muscle contraction_Homo sapiens_hsa042600.58499496
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57049807
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56736978
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55949519
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55547143
115Axon guidance_Homo sapiens_hsa043600.54514595
116Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53963647
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53938965
118ErbB signaling pathway_Homo sapiens_hsa040120.53638167
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52857292
120Tyrosine metabolism_Homo sapiens_hsa003500.52479884
121Nucleotide excision repair_Homo sapiens_hsa034200.52473402
122Histidine metabolism_Homo sapiens_hsa003400.52071017
123Parkinsons disease_Homo sapiens_hsa050120.51891691
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51127727
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50839474
126Inositol phosphate metabolism_Homo sapiens_hsa005620.50701266
127Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49427089
128Arginine and proline metabolism_Homo sapiens_hsa003300.47612467
129Dilated cardiomyopathy_Homo sapiens_hsa054140.47549140
130Sphingolipid metabolism_Homo sapiens_hsa006000.45411872
131Fat digestion and absorption_Homo sapiens_hsa049750.44212897
132Rheumatoid arthritis_Homo sapiens_hsa053230.43736947
133Endometrial cancer_Homo sapiens_hsa052130.43665143
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43657159
135TGF-beta signaling pathway_Homo sapiens_hsa043500.43316653
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42645443
137Pancreatic secretion_Homo sapiens_hsa049720.42506830
138Dorso-ventral axis formation_Homo sapiens_hsa043200.42174581
139Ras signaling pathway_Homo sapiens_hsa040140.40142405
140Butanoate metabolism_Homo sapiens_hsa006500.36315949
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36048239
142Purine metabolism_Homo sapiens_hsa002300.35941454
143Glioma_Homo sapiens_hsa052140.35451129
144MAPK signaling pathway_Homo sapiens_hsa040100.35431604
145Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34996383
146Melanoma_Homo sapiens_hsa052180.33094324
147Hippo signaling pathway_Homo sapiens_hsa043900.30383590
148Choline metabolism in cancer_Homo sapiens_hsa052310.30080456
149Oocyte meiosis_Homo sapiens_hsa041140.29151809
150Ovarian steroidogenesis_Homo sapiens_hsa049130.28272615
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28195481
152Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24386167
153Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22971614
154Phagosome_Homo sapiens_hsa041450.22252634
155Pyruvate metabolism_Homo sapiens_hsa006200.22109182
156Prostate cancer_Homo sapiens_hsa052150.21361103

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