TTC9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains three tetratricopeptide repeats. The gene has been shown to be hormonally regulated in breast cancer cells and may play a role in cancer cell invasion and metastasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)6.38718386
2keratinization (GO:0031424)5.57080054
3motile cilium assembly (GO:0044458)4.94811928
4synaptic vesicle maturation (GO:0016188)4.93141349
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.88605025
6apical protein localization (GO:0045176)4.83468292
7cilium or flagellum-dependent cell motility (GO:0001539)4.81137190
8primary alcohol catabolic process (GO:0034310)4.75768862
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.47853575
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38662302
11regulation of ARF protein signal transduction (GO:0032012)4.35007875
12negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.31242187
13layer formation in cerebral cortex (GO:0021819)4.26729849
14glutamate secretion (GO:0014047)4.26249367
15regulation of synaptic vesicle exocytosis (GO:2000300)4.16853608
16cilium movement (GO:0003341)4.14092183
17synaptic vesicle exocytosis (GO:0016079)4.06636221
18locomotory exploration behavior (GO:0035641)4.06429754
19negative regulation of potassium ion transmembrane transport (GO:1901380)4.03405248
20neuronal action potential propagation (GO:0019227)3.95078546
21positive regulation of microtubule polymerization (GO:0031116)3.92133728
22positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.75769389
23regulation of interleukin-13 production (GO:0032656)3.69438386
24keratinocyte differentiation (GO:0030216)3.66939830
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66357834
26establishment of skin barrier (GO:0061436)3.63188275
27proline transport (GO:0015824)3.60244062
28cell migration in hindbrain (GO:0021535)3.57070189
29vocalization behavior (GO:0071625)3.56599225
30regulation of synapse structural plasticity (GO:0051823)3.56089254
31cellular potassium ion homeostasis (GO:0030007)3.54262816
32plasma membrane repair (GO:0001778)3.53686315
33activation of protein kinase A activity (GO:0034199)3.52987119
34regulation of water loss via skin (GO:0033561)3.52620428
35regulation of synaptic vesicle transport (GO:1902803)3.50680841
36sodium ion export (GO:0071436)3.47589195
37tolerance induction (GO:0002507)3.44678755
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44411144
39multicellular organismal water homeostasis (GO:0050891)3.43417659
40asymmetric protein localization (GO:0008105)3.41346508
41peptide cross-linking (GO:0018149)3.40933281
42histone H3-K36 demethylation (GO:0070544)3.37946081
43neuron cell-cell adhesion (GO:0007158)3.37361397
44protein localization to synapse (GO:0035418)3.36748079
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.32963979
46epithelial cilium movement (GO:0003351)3.31814123
47membrane depolarization during action potential (GO:0086010)3.31371749
48positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30466266
49regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.26516742
50epithelial cell differentiation involved in kidney development (GO:0035850)3.25799099
51regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25529161
52neurofilament cytoskeleton organization (GO:0060052)3.24949607
53vesicle transport along microtubule (GO:0047496)3.23380461
54membrane assembly (GO:0071709)3.23261117
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.22319051
56membrane raft organization (GO:0031579)3.21300738
57cellular response to nerve growth factor stimulus (GO:1990090)3.20173512
58response to nerve growth factor (GO:1990089)3.20173512
59axon cargo transport (GO:0008088)3.19084715
60B cell homeostasis (GO:0001782)3.18452099
61regulation of sarcomere organization (GO:0060297)3.16816066
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15337008
63peptidyl-tyrosine autophosphorylation (GO:0038083)3.15108628
64exploration behavior (GO:0035640)3.14128051
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.13298072
66localization within membrane (GO:0051668)3.13121369
67neurotransmitter secretion (GO:0007269)3.11037179
68striated muscle atrophy (GO:0014891)3.10226099
69positive regulation of tolerance induction (GO:0002645)3.09553425
70neuronal action potential (GO:0019228)3.08538304
71cell communication involved in cardiac conduction (GO:0086065)3.07766306
72cerebellar granule cell differentiation (GO:0021707)3.07168776
73dendrite morphogenesis (GO:0048813)3.05791340
74regulation of neuronal synaptic plasticity (GO:0048168)3.05008339
75detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.04293025
76detection of temperature stimulus involved in sensory perception (GO:0050961)3.04293025
77organelle transport along microtubule (GO:0072384)3.00193391
78positive regulation of myotube differentiation (GO:0010831)2.98921834
79ear development (GO:0043583)2.98079245
80neuromuscular process controlling balance (GO:0050885)2.97601077
81cell communication by electrical coupling (GO:0010644)2.97490283
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.97266220
83detection of temperature stimulus (GO:0016048)2.96274503
84regulation of glutamate receptor signaling pathway (GO:1900449)2.95564372
85regulation of long-term neuronal synaptic plasticity (GO:0048169)2.95238942
86innervation (GO:0060384)2.95079981
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.92358381
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91807438
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91646105
90regulation of germinal center formation (GO:0002634)2.90941832
91glycine transport (GO:0015816)2.90209952
92ventricular cardiac muscle cell action potential (GO:0086005)2.90005338
93regulation of interleukin-5 production (GO:0032674)2.89204408
94response to parathyroid hormone (GO:0071107)2.88927544
95regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88238581
96long-chain fatty acid biosynthetic process (GO:0042759)2.87853025
97negative regulation of muscle hypertrophy (GO:0014741)2.87363729
98negative regulation of cell killing (GO:0031342)2.86627927
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.86627927
100negative regulation of microtubule polymerization (GO:0031115)2.86579129
101regulation of NFAT protein import into nucleus (GO:0051532)2.86413776
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.85748945
103positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.85208553
104calcium ion-dependent exocytosis (GO:0017156)2.83807866
105water homeostasis (GO:0030104)2.83341617
106gamma-aminobutyric acid transport (GO:0015812)2.82908282
107epidermal cell differentiation (GO:0009913)2.82641325
108myotube differentiation (GO:0014902)2.81656446
109regulation of p38MAPK cascade (GO:1900744)2.80989076
110signal complex assembly (GO:0007172)2.80464106
111ethanol metabolic process (GO:0006067)2.80246439
112dendritic spine morphogenesis (GO:0060997)2.79394775
113positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.79128635
114negative regulation of B cell mediated immunity (GO:0002713)2.78835394
115negative regulation of immunoglobulin mediated immune response (GO:0002890)2.78835394
116neuron recognition (GO:0008038)2.78609693
117ionotropic glutamate receptor signaling pathway (GO:0035235)2.77290845
118negative regulation of toll-like receptor signaling pathway (GO:0034122)2.77252213
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.76805963
120cerebellar Purkinje cell differentiation (GO:0021702)2.75053285
121positive regulation of synaptic transmission, GABAergic (GO:0032230)2.74335798
122axonal fasciculation (GO:0007413)2.73343318
123positive regulation of Rap GTPase activity (GO:0032854)2.71931939
124neuromuscular synaptic transmission (GO:0007274)2.71889201
125clathrin coat assembly (GO:0048268)2.71674357
126establishment of planar polarity (GO:0001736)2.71000317
127establishment of tissue polarity (GO:0007164)2.71000317
128production of molecular mediator involved in inflammatory response (GO:0002532)2.70326431
129negative regulation of heart growth (GO:0061117)2.70246869
130negative regulation of cardiac muscle tissue growth (GO:0055022)2.70246869
131regulation of tolerance induction (GO:0002643)2.69778400
132regulation of neurotransmitter secretion (GO:0046928)2.69697698
133negative regulation of inclusion body assembly (GO:0090084)2.69095619
134regulation of vesicle fusion (GO:0031338)2.68982528
135mating behavior (GO:0007617)2.67847946
136negative regulation of protein localization to cell surface (GO:2000009)2.67521500
137intestinal epithelial cell development (GO:0060576)2.67210057
138positive regulation of potassium ion transmembrane transport (GO:1901381)2.67006888
139negative regulation of cation channel activity (GO:2001258)2.66580320
140positive regulation of potassium ion transport (GO:0043268)2.65876930
141negative regulation of dendrite morphogenesis (GO:0050774)2.65469863
142sensory perception of smell (GO:0007608)2.65299622
143desmosome organization (GO:0002934)2.65163561
144O-glycan processing (GO:0016266)2.65143503
145membrane repolarization (GO:0086009)2.65041079
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60014273
147regulation of microtubule polymerization (GO:0031113)2.58293333
148neurotransmitter transport (GO:0006836)2.57936228
149positive regulation of vesicle fusion (GO:0031340)2.57856130
150axoneme assembly (GO:0035082)2.57051696
151detection of bacterium (GO:0016045)2.56465671
152transmission of nerve impulse (GO:0019226)2.55562517
153positive regulation of axon extension (GO:0045773)2.54125518
154dopamine receptor signaling pathway (GO:0007212)2.54075388
155regulation of voltage-gated calcium channel activity (GO:1901385)2.54010056
156prepulse inhibition (GO:0060134)2.53987186
157synaptic transmission, glutamatergic (GO:0035249)2.52941620
158neuromuscular process (GO:0050905)2.52429336
159neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.52213971
160germinal center formation (GO:0002467)2.51160794
161regulation of neurotransmitter transport (GO:0051588)2.50310905
162postsynaptic membrane organization (GO:0001941)2.49860478
163regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.49801933
164neuron-neuron synaptic transmission (GO:0007270)2.49705582
165cytoplasmic microtubule organization (GO:0031122)2.49221492
166regulation of synaptic plasticity (GO:0048167)2.49125185
167synapse assembly (GO:0007416)2.48754285
168membrane depolarization (GO:0051899)2.48134985
169glutamate receptor signaling pathway (GO:0007215)2.48060345
170adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.47595928
171synapse organization (GO:0050808)2.47405178
172potassium ion homeostasis (GO:0055075)2.47404254
173regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.47377594
174negative regulation of organelle assembly (GO:1902116)2.47151873
175nerve growth factor signaling pathway (GO:0038180)2.46879958
176regulation of calcium ion transmembrane transporter activity (GO:1901019)2.46846691
177regulation of calcium ion transmembrane transport (GO:1903169)2.46846691
178regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44754191
179diterpenoid biosynthetic process (GO:0016102)2.42126103
180negative regulation of B cell proliferation (GO:0030889)2.41229016
181negative regulation of lymphocyte mediated immunity (GO:0002707)2.40397831
182muscle atrophy (GO:0014889)2.40185777
183negative regulation of cardiac muscle hypertrophy (GO:0010614)2.39670756
184regulation of Rap GTPase activity (GO:0032317)2.38408944
185regulation of clathrin-mediated endocytosis (GO:2000369)2.37123702
186detection of other organism (GO:0098543)2.35495637

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01143901
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.56928258
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55567372
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39169474
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.38934000
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.38934000
7KDM2B_26808549_Chip-Seq_SUP-B15_Human2.37348876
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.36483642
9* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33524061
10MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29891563
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27204233
12GBX2_23144817_ChIP-Seq_PC3_Human2.20717089
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18488725
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14821789
15DROSHA_22980978_ChIP-Seq_HELA_Human2.09378724
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07895711
17REST_21632747_ChIP-Seq_MESCs_Mouse2.04546374
18SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02816581
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01372241
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00795249
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.00697385
22TCF7_22412390_ChIP-Seq_EML_Mouse2.00526088
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00089861
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00089861
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00089861
26MYC_22102868_ChIP-Seq_BL_Human1.99929518
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.99110022
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.92721487
29KDM2B_26808549_Chip-Seq_DND41_Human1.90730932
30* RARB_27405468_Chip-Seq_BRAIN_Mouse1.89984257
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89751785
32* RNF2_27304074_Chip-Seq_ESCs_Mouse1.86476515
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86293575
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.81323347
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.74990947
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74122857
37STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73199595
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68672229
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67285179
40* RACK7_27058665_Chip-Seq_MCF-7_Human1.66491216
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.64201322
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64179372
43* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64028606
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57363906
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.54107974
46* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.53190688
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51121715
48AR_21572438_ChIP-Seq_LNCaP_Human1.50631731
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50611884
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45751560
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.45429027
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44637915
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44465904
54ZNF274_21170338_ChIP-Seq_K562_Hela1.43343086
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.42848651
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42758237
57ZNF263_19887448_ChIP-Seq_K562_Human1.42474213
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42281902
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.41758649
60AHR_22903824_ChIP-Seq_MCF-7_Human1.41652469
61CREB1_26743006_Chip-Seq_LNCaP_Human1.41630351
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.40145620
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39956457
64KDM2B_26808549_Chip-Seq_K562_Human1.39790160
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.39617045
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.38934584
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.38773146
68* KLF5_25053715_ChIP-Seq_YYC3_Human1.38772773
69* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38420845
70SMAD4_21799915_ChIP-Seq_A2780_Human1.37938319
71TAF15_26573619_Chip-Seq_HEK293_Human1.37202728
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37186633
73ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37165090
74SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37134184
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33110367
76GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30860540
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.28852682
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27182133
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26927416
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26155295
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25306491
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.24798109
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24523052
84SMC4_20622854_ChIP-Seq_HELA_Human1.24151172
85LXR_22292898_ChIP-Seq_THP-1_Human1.24050851
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23016925
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.22821339
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22321939
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21556363
90PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.20845513
91TP63_17297297_ChIP-ChIP_HaCaT_Human1.18379871
92FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.18242147
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14923039
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14320372
95MAF_26560356_Chip-Seq_TH1_Human1.13509769
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.12711880
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.11320077
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11138915
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10115429
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.09851333
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09548160
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08879453
103RUNX_20019798_ChIP-Seq_JUKART_Human1.08044433
104VDR_22108803_ChIP-Seq_LS180_Human1.08019406
105TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07437782
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05742208
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04866075
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03670644
109RING1B_27294783_Chip-Seq_NPCs_Mouse1.03286085
110CTCF_27219007_Chip-Seq_Bcells_Human1.03172975
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02969523
112TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02549797
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.02181627
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01520204
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01462902
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01306420
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00965296
118ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00716633
119* STAT3_23295773_ChIP-Seq_U87_Human1.00276459
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.99962581
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.99437539
122AR_19668381_ChIP-Seq_PC3_Human0.99031449
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98779540
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98692145
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98518689
126TP53_18474530_ChIP-ChIP_U2OS_Human0.98454086
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98161351
128VDR_21846776_ChIP-Seq_THP-1_Human0.97579752
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97509824
130AR_25329375_ChIP-Seq_VCAP_Human0.97087998
131VDR_24763502_ChIP-Seq_THP-1_Human0.96763448
132PIAS1_25552417_ChIP-Seq_VCAP_Human0.95513653
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95154056
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.94726207
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94401146
136* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93406786
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.92071295
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91447553
139TP63_22573176_ChIP-Seq_HFKS_Human0.91101481
140OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.90006004
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.89730444
142BCAT_22108803_ChIP-Seq_LS180_Human0.88899112
143* P300_19829295_ChIP-Seq_ESCs_Human0.88885294
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87891949
145NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86992654
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86546524
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.86294035
148* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85438936
149P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85382776
150ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84537860
151TP53_20018659_ChIP-ChIP_R1E_Mouse0.84290506
152EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84190159
153MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84057237
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.83888768
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.83640883
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.82879601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.83496063
2MP0004270_analgesia4.66047675
3MP0001968_abnormal_touch/_nociception3.77996907
4MP0002735_abnormal_chemical_nociception3.71147752
5MP0002734_abnormal_mechanical_nocicepti3.24579440
6MP0003635_abnormal_synaptic_transmissio3.14232518
7MP0002736_abnormal_nociception_after3.13901387
8MP0003880_abnormal_central_pattern3.02959515
9MP0004858_abnormal_nervous_system3.00283217
10MP0001984_abnormal_olfaction2.74312517
11MP0002733_abnormal_thermal_nociception2.73188903
12MP0001970_abnormal_pain_threshold2.44170013
13MP0009046_muscle_twitch2.42534770
14MP0005501_abnormal_skin_physiology2.38828941
15MP0002063_abnormal_learning/memory/cond2.38641202
16MP0009745_abnormal_behavioral_response2.32168020
17MP0002064_seizures2.24705398
18MP0002272_abnormal_nervous_system2.22331608
19MP0003329_amyloid_beta_deposits2.19808974
20MP0002653_abnormal_ependyma_morphology2.17015402
21MP0002184_abnormal_innervation2.13896645
22MP0003453_abnormal_keratinocyte_physiol2.01540158
23MP0002909_abnormal_adrenal_gland2.01475723
24MP0005423_abnormal_somatic_nervous2.00159371
25MP0010234_abnormal_vibrissa_follicle2.00081609
26MP0010678_abnormal_skin_adnexa1.95561493
27MP0009780_abnormal_chondrocyte_physiolo1.94888954
28MP0002572_abnormal_emotion/affect_behav1.90844890
29MP0004264_abnormal_extraembryonic_tissu1.88676481
30MP0006276_abnormal_autonomic_nervous1.83656679
31MP0001346_abnormal_lacrimal_gland1.83540443
32MP0004811_abnormal_neuron_physiology1.79403730
33MP0002067_abnormal_sensory_capabilities1.75119823
34MP0000778_abnormal_nervous_system1.75030221
35MP0001486_abnormal_startle_reflex1.69259289
36MP0000955_abnormal_spinal_cord1.68046781
37MP0005623_abnormal_meninges_morphology1.67811633
38MP0001440_abnormal_grooming_behavior1.65953899
39MP0000751_myopathy1.64038963
40MP0003303_peritoneal_inflammation1.62700102
41MP0002822_catalepsy1.60337126
42MP0008569_lethality_at_weaning1.60325981
43MP0004145_abnormal_muscle_electrophysio1.54457250
44MP0003763_abnormal_thymus_physiology1.53224438
45MP0002277_abnormal_respiratory_mucosa1.50099784
46MP0000467_abnormal_esophagus_morphology1.49380480
47MP0001348_abnormal_lacrimal_gland1.47081310
48MP0005410_abnormal_fertilization1.43360586
49MP0004043_abnormal_pH_regulation1.42591425
50MP0000537_abnormal_urethra_morphology1.41601093
51MP0002882_abnormal_neuron_morphology1.39957362
52MP0000013_abnormal_adipose_tissue1.38984930
53MP0000566_synostosis1.38134408
54MP0001188_hyperpigmentation1.35658682
55MP0003828_pulmonary_edema1.32938530
56MP0001299_abnormal_eye_distance/1.29372628
57MP0003634_abnormal_glial_cell1.28160517
58MP0000678_abnormal_parathyroid_gland1.27781724
59MP0000747_muscle_weakness1.26922643
60MP0003941_abnormal_skin_development1.26373319
61MP0002557_abnormal_social/conspecific_i1.25173814
62MP0003633_abnormal_nervous_system1.23971068
63MP0004133_heterotaxia1.22537501
64MP0000920_abnormal_myelination1.21369378
65MP0004381_abnormal_hair_follicle1.21268019
66MP0002098_abnormal_vibrissa_morphology1.20939929
67MP0008875_abnormal_xenobiotic_pharmacok1.20219903
68MP0002066_abnormal_motor_capabilities/c1.20116620
69MP0003787_abnormal_imprinting1.19736363
70MP0001501_abnormal_sleep_pattern1.19433111
71MP0001851_eye_inflammation1.19051614
72MP0004885_abnormal_endolymph1.15664177
73MP0003950_abnormal_plasma_membrane1.15612999
74MP0001485_abnormal_pinna_reflex1.15405780
75MP0004924_abnormal_behavior1.14494758
76MP0005386_behavior/neurological_phenoty1.14494758
77MP0000749_muscle_degeneration1.13318873
78MP0001873_stomach_inflammation1.12480763
79MP0005076_abnormal_cell_differentiation1.12066137
80MP0010352_gastrointestinal_tract_polyps1.11848960
81MP0005377_hearing/vestibular/ear_phenot1.10559799
82MP0003878_abnormal_ear_physiology1.10559799
83MP0003879_abnormal_hair_cell1.08571166
84MP0003631_nervous_system_phenotype1.08230922
85MP0001849_ear_inflammation1.06183907
86MP0003938_abnormal_ear_development1.02544828
87MP0000465_gastrointestinal_hemorrhage1.02263289
88MP0000685_abnormal_immune_system1.01559998
89MP0009672_abnormal_birth_weight1.01288390
90MP0001986_abnormal_taste_sensitivity1.01022966
91MP0002254_reproductive_system_inflammat1.00697126
92MP0000377_abnormal_hair_follicle0.99778028
93MP0002249_abnormal_larynx_morphology0.98299901
94MP0000383_abnormal_hair_follicle0.98041404
95MP0003566_abnormal_cell_adhesion0.97838578
96MP0003705_abnormal_hypodermis_morpholog0.96792251
97MP0003122_maternal_imprinting0.96252482
98MP0005387_immune_system_phenotype0.95026875
99MP0001790_abnormal_immune_system0.95026875
100MP0003890_abnormal_embryonic-extraembry0.94677020
101MP0005248_abnormal_Harderian_gland0.94540688
102MP0002229_neurodegeneration0.93847938
103MP0000534_abnormal_ureter_morphology0.92312127
104MP0001216_abnormal_epidermal_layer0.92266342
105MP0004947_skin_inflammation0.91727514
106MP0003045_fibrosis0.90805934
107MP0003632_abnormal_nervous_system0.88458145
108MP0004185_abnormal_adipocyte_glucose0.87754272
109MP0003861_abnormal_nervous_system0.87729656
110MP0002152_abnormal_brain_morphology0.87609978
111MP0005083_abnormal_biliary_tract0.87246290
112MP0002752_abnormal_somatic_nervous0.86232106
113MP0005499_abnormal_olfactory_system0.84904872
114MP0005394_taste/olfaction_phenotype0.84904872
115MP0002089_abnormal_postnatal_growth/wei0.84034452
116MP0002234_abnormal_pharynx_morphology0.83630874
117MP0003123_paternal_imprinting0.82909831
118MP0000604_amyloidosis0.82685565
119MP0005310_abnormal_salivary_gland0.82290818
120MP0004883_abnormal_blood_vessel0.80567715
121MP0001765_abnormal_ion_homeostasis0.79678096
122MP0004142_abnormal_muscle_tone0.79645892
123MP0008961_abnormal_basal_metabolism0.79397682
124MP0002133_abnormal_respiratory_system0.79219126
125MP0005388_respiratory_system_phenotype0.79219126
126MP0004742_abnormal_vestibular_system0.79030591
127MP0002796_impaired_skin_barrier0.78186274
128MP0002751_abnormal_autonomic_nervous0.78044539
129MP0003283_abnormal_digestive_organ0.77706502
130MP0001177_atelectasis0.76737876
131MP0000762_abnormal_tongue_morphology0.76180690
132MP0001800_abnormal_humoral_immune0.74929269
133MP0008874_decreased_physiological_sensi0.73109229
134MP0004085_abnormal_heartbeat0.72973133
135MP0005645_abnormal_hypothalamus_physiol0.71074198
136MP0010630_abnormal_cardiac_muscle0.70652312
137MP0010771_integument_phenotype0.69995249
138MP0000759_abnormal_skeletal_muscle0.69649258
139MP0005646_abnormal_pituitary_gland0.68886289
140MP0001905_abnormal_dopamine_level0.68639596
141MP0003075_altered_response_to0.67726016
142MP0001943_abnormal_respiration0.67312851
143MP0004087_abnormal_muscle_fiber0.64979837
144MP0001502_abnormal_circadian_rhythm0.64943428
145MP0005187_abnormal_penis_morphology0.64625476
146MP0004484_altered_response_of0.64101018
147MP0004272_abnormal_basement_membrane0.63073007
148MP0002837_dystrophic_cardiac_calcinosis0.61895463
149MP0008789_abnormal_olfactory_epithelium0.61615043
150MP0001664_abnormal_digestion0.59392297
151MP0000579_abnormal_nail_morphology0.59212914
152MP0002069_abnormal_eating/drinking_beha0.59199757
153MP0004036_abnormal_muscle_relaxation0.57305829
154MP0005409_darkened_coat_color0.57063495
155MP0003690_abnormal_glial_cell0.56978705
156MP0003183_abnormal_peptide_metabolism0.56946329
157MP0010386_abnormal_urinary_bladder0.55930448
158MP0005275_abnormal_skin_tensile0.55679473
159MP0004233_abnormal_muscle_weight0.55533855
160MP0005620_abnormal_muscle_contractility0.55433464

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)5.77034627
2Abnormal respiratory epithelium morphology (HP:0012253)5.77034627
3Myokymia (HP:0002411)5.67101530
4Abnormal ciliary motility (HP:0012262)5.43661038
5Rhinitis (HP:0012384)5.30139424
6Nasal polyposis (HP:0100582)5.06658572
7Bronchiectasis (HP:0002110)4.93464910
8Action tremor (HP:0002345)4.29149597
9Ulnar claw (HP:0001178)4.17660716
10Termporal pattern (HP:0011008)3.88921677
11Insidious onset (HP:0003587)3.88921677
12Focal motor seizures (HP:0011153)3.87992496
13Abnormality of the nasal mucosa (HP:0000433)3.81741889
14Bronchitis (HP:0012387)3.78405025
15Recurrent sinusitis (HP:0011108)3.68335370
16Supranuclear gaze palsy (HP:0000605)3.66675506
17Focal seizures (HP:0007359)3.64277237
18Obstructive sleep apnea (HP:0002870)3.56842984
19Increased IgE level (HP:0003212)3.47792360
20Hyperactive renin-angiotensin system (HP:0000841)3.46225804
21Fetal akinesia sequence (HP:0001989)3.41720907
22Lip pit (HP:0100267)3.40831934
23Abnormality of the salivary glands (HP:0010286)3.37348348
24Ankle clonus (HP:0011448)3.33119970
25Visual hallucinations (HP:0002367)3.30381623
26Atonic seizures (HP:0010819)3.26611384
27Abnormality of the left ventricular outflow tract (HP:0011103)3.23120355
28Subaortic stenosis (HP:0001682)3.23120355
29Distal lower limb muscle weakness (HP:0009053)3.23088776
30Calf muscle hypertrophy (HP:0008981)3.21721983
31Hyporeflexia of lower limbs (HP:0002600)3.15705615
32Recurrent otitis media (HP:0000403)3.09241022
33Progressive cerebellar ataxia (HP:0002073)3.02029564
34Distal arthrogryposis (HP:0005684)2.94328263
35Neurofibrillary tangles (HP:0002185)2.94033012
36Muscle hypertrophy of the lower extremities (HP:0008968)2.88842026
37Akinesia (HP:0002304)2.81231864
38Segmental peripheral demyelination/remyelination (HP:0003481)2.79236412
39Pheochromocytoma (HP:0002666)2.78292137
40Foot dorsiflexor weakness (HP:0009027)2.73860280
41Cerebral inclusion bodies (HP:0100314)2.68602680
42Sudden death (HP:0001699)2.67804787
43Absence seizures (HP:0002121)2.67302134
44Pustule (HP:0200039)2.59090540
45Eczematoid dermatitis (HP:0000976)2.58288202
46Chronic sinusitis (HP:0011109)2.55941106
47Urinary urgency (HP:0000012)2.54399159
48Infertility (HP:0000789)2.53698924
49Neuroendocrine neoplasm (HP:0100634)2.52915504
50Epileptic encephalopathy (HP:0200134)2.51343550
51Arterial tortuosity (HP:0005116)2.48935136
52Limb dystonia (HP:0002451)2.48023621
53Abnormality of the foot musculature (HP:0001436)2.47642993
54Muscle fiber inclusion bodies (HP:0100299)2.46699281
55Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46695761
56Febrile seizures (HP:0002373)2.46654776
57Hammertoe (HP:0001765)2.44997572
58Difficulty running (HP:0009046)2.43015558
59Myotonia (HP:0002486)2.42895184
60Abnormality of the corticospinal tract (HP:0002492)2.42893105
61Onion bulb formation (HP:0003383)2.41495335
62Nemaline bodies (HP:0003798)2.39292076
63Depression (HP:0000716)2.39049053
64Sleep apnea (HP:0010535)2.38920518
65Generalized tonic-clonic seizures (HP:0002069)2.38691629
66Steppage gait (HP:0003376)2.37050380
67Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.36267043
68Truncal ataxia (HP:0002078)2.36203895
69Mutism (HP:0002300)2.35305399
70Megalencephaly (HP:0001355)2.35065495
71Dialeptic seizures (HP:0011146)2.34370041
72Exercise-induced muscle cramps (HP:0003710)2.34260967
73Hypercortisolism (HP:0001578)2.31977613
74Ventricular fibrillation (HP:0001663)2.31967028
75Parakeratosis (HP:0001036)2.31322187
76Nonprogressive disorder (HP:0003680)2.31312409
77Popliteal pterygium (HP:0009756)2.30607040
78Hyperkalemia (HP:0002153)2.29291539
79Urinary bladder sphincter dysfunction (HP:0002839)2.28516374
80Papilledema (HP:0001085)2.25465751
81Rapidly progressive (HP:0003678)2.22322952
82Chronic otitis media (HP:0000389)2.21659207
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20621023
84Renal salt wasting (HP:0000127)2.18826808
85Lower limb muscle weakness (HP:0007340)2.18567549
86Scanning speech (HP:0002168)2.14355412
87Torticollis (HP:0000473)2.13318406
88Spastic gait (HP:0002064)2.11985375
89Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.11205722
90Dysmetria (HP:0001310)2.09856938
91Asymmetric septal hypertrophy (HP:0001670)2.09295781
92Oral leukoplakia (HP:0002745)2.08338220
93Abnormality of nail color (HP:0100643)2.08300651
94Amblyopia (HP:0000646)2.07194090
95Lower limb amyotrophy (HP:0007210)2.05518206
96Anxiety (HP:0000739)2.04346263
97Sparse scalp hair (HP:0002209)2.04185788
98Retinal dysplasia (HP:0007973)2.02836233
99Impaired vibration sensation in the lower limbs (HP:0002166)2.02227772
100Lower limb asymmetry (HP:0100559)2.00843395
101Recurrent bronchitis (HP:0002837)2.00312201
102Distal sensory impairment (HP:0002936)1.99405809
103Decreased motor nerve conduction velocity (HP:0003431)1.96974973
104Peripheral hypomyelination (HP:0007182)1.95126658
105Abnormality of the lower motor neuron (HP:0002366)1.94470876
106Postural tremor (HP:0002174)1.91691046
107Progressive inability to walk (HP:0002505)1.90434667
108Gaze-evoked nystagmus (HP:0000640)1.89388099
109Postural instability (HP:0002172)1.89343385
110Abnormality of the dental root (HP:0006486)1.88981491
111Taurodontia (HP:0000679)1.88981491
112Abnormality of permanent molar morphology (HP:0011071)1.88981491
113Abnormality of pain sensation (HP:0010832)1.88866637
114Impaired pain sensation (HP:0007328)1.88866637
115Aplasia involving bones of the extremities (HP:0009825)1.88686543
116Aplasia involving bones of the upper limbs (HP:0009823)1.88686543
117Aplasia of the phalanges of the hand (HP:0009802)1.88686543
118Dysdiadochokinesis (HP:0002075)1.87893782
119Congenital ichthyosiform erythroderma (HP:0007431)1.87719910
120Difficulty climbing stairs (HP:0003551)1.87102319
121Intention tremor (HP:0002080)1.86976303
122Vascular tortuosity (HP:0004948)1.86900441
123Turricephaly (HP:0000262)1.85366724
124Insomnia (HP:0100785)1.85139961
125Neoplasm of the peripheral nervous system (HP:0100007)1.85061006
126Abnormality of the vocal cords (HP:0008777)1.83941651
127Exercise-induced myalgia (HP:0003738)1.83731053
128Hypoplasia of the brainstem (HP:0002365)1.82757212
129Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82757212
130Abnormal respiratory motile cilium physiology (HP:0012261)1.82384573
131Increased variability in muscle fiber diameter (HP:0003557)1.82095332
132Bronchomalacia (HP:0002780)1.80562533
133Oligodontia (HP:0000677)1.79491959
134Gowers sign (HP:0003391)1.78689686
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.77979947
136Absent/shortened dynein arms (HP:0200106)1.77979947
137Curly hair (HP:0002212)1.77822567
138Male infertility (HP:0003251)1.75583377
139Hypotrichosis (HP:0001006)1.75242060
140Broad-based gait (HP:0002136)1.74568386
141Sensory axonal neuropathy (HP:0003390)1.73960865
142Abnormal eating behavior (HP:0100738)1.73768537
143Chronic bronchitis (HP:0004469)1.73240271
144Buphthalmos (HP:0000557)1.72617824
145Slow progression (HP:0003677)1.72345630
146Pili torti (HP:0003777)1.71512335
147Focal dystonia (HP:0004373)1.70988606
148Agitation (HP:0000713)1.70616141
149Muscle fiber splitting (HP:0003555)1.70594909
150Abnormality of molar (HP:0011077)1.70091048
151Abnormality of molar morphology (HP:0011070)1.70091048
152Distal upper limb amyotrophy (HP:0007149)1.68408469
153Depressed nasal tip (HP:0000437)1.65181342
154Tubulointerstitial nephritis (HP:0001970)1.63834283
155Right ventricular cardiomyopathy (HP:0011663)1.61469895
156Abnormality of the dental pulp (HP:0006479)1.59891373
157Muscle stiffness (HP:0003552)1.59200761
158Neonatal hypoglycemia (HP:0001998)1.56365284
159Fatigable weakness (HP:0003473)1.55074418
160Abnormality of the neuromuscular junction (HP:0003398)1.55074418
161Abnormal hair whorl (HP:0010721)1.54751559
162Cystic hygroma (HP:0000476)1.54120017
163Verrucae (HP:0200043)1.53964498
164Papilloma (HP:0012740)1.53964498
165Gastrointestinal stroma tumor (HP:0100723)1.52899724
166Papillary thyroid carcinoma (HP:0002895)1.51492516
167Abnormality of incisor morphology (HP:0011063)1.51434906
168Recurrent bacterial skin infections (HP:0005406)1.48323406
169Split foot (HP:0001839)1.46648906
170Labial hypoplasia (HP:0000066)1.46347616
171Abnormality of chloride homeostasis (HP:0011422)1.41843403

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.10876372
2NTRK33.08547993
3MARK13.06705975
4PRPF4B2.88130415
5NTRK12.86024501
6KSR22.74445647
7MINK12.60220097
8MAP3K22.55936951
9SIK22.41222568
10MAPK152.40420449
11PRKD32.25774977
12STK242.24969264
13MAP3K132.22928166
14SMG12.20368993
15PAK62.16130232
16PHKG22.06743318
17PHKG12.06743318
18LATS22.02035623
19LIMK11.97565437
20MAP3K101.94332915
21MAP3K41.94212822
22TNIK1.89720519
23DAPK21.85189820
24LMTK21.79572446
25MAP4K11.79427483
26EPHA41.74657471
27GRK51.72150329
28CAMKK11.60603945
29SGK21.54388966
30RET1.53682772
31MAP2K41.48476558
32MAP3K121.44415768
33FER1.40629600
34MAP3K71.40509708
35CDK121.39654993
36CDK51.33467618
37MAP2K71.32552773
38NTRK21.27548009
39SIK11.27469764
40SIK31.26414202
41ARAF1.26308855
42NME11.25902460
43CSK1.25764952
44RIPK11.18065819
45STK391.17233605
46TESK11.15848157
47PAK31.15560965
48CAMKK21.15322113
49MST41.10232187
50TRIB31.08533989
51MAP2K11.07582886
52CDK141.06123658
53PKN21.06108661
54KSR11.03331893
55MAPK121.01023330
56STK381.00740979
57TAOK10.98566532
58PNCK0.95823861
59ERBB30.95814287
60MELK0.95755137
61EPHB10.94646773
62MAP3K30.94439584
63EPHB20.93286175
64PTK2B0.92244933
65TYRO30.91460835
66MAP3K10.89723135
67MAPK130.88270659
68PLK20.87339845
69RIPK40.86842632
70CSNK1G20.86046969
71PASK0.85602122
72WNK10.85503479
73CDK150.85245428
74CDK180.84384674
75CCNB10.83701845
76UHMK10.83688320
77PDK30.81382024
78PDK40.81382024
79ICK0.81329529
80MARK20.81118912
81SGK2230.80362277
82SGK4940.80362277
83EEF2K0.80172461
84PRKCG0.79152685
85PTK20.78032049
86IKBKE0.77809904
87CAMK2A0.77789570
88CAMK2B0.77650669
89MAPKAPK30.77642321
90PRKCH0.76092887
91EPHA20.76066201
92FGFR20.75733771
93STK110.75452661
94LRRK20.73815336
95CDK11A0.73607891
96FGFR40.72206434
97GRK60.71829991
98CAMK2D0.71753880
99RPS6KA20.71599103
100SCYL20.71379052
101ROCK20.69136209
102CASK0.68814342
103CAMK2G0.67088815
104YES10.66434484
105MOS0.64507223
106PRKCQ0.64370587
107PDPK10.64258497
108NEK60.64232912
109WNK40.63418594
110HIPK20.62434156
111CDK190.61683261
112SGK10.60977879
113PTK60.59289534
114PDK10.58685825
115PRKCE0.57910781
116ALK0.57660508
117TAF10.57303976
118ZAP700.52506283
119DYRK20.51729661
120ILK0.51553120
121BCR0.51042929
122ERN10.51011260
123NLK0.50341969
124DMPK0.49999266
125DAPK10.49591910
126DDR20.48941098
127PRKCZ0.48548603
128OXSR10.48517201
129TNK20.47928862
130IRAK40.47728385
131ROCK10.47177618
132PDGFRA0.46150462
133MUSK0.45800630
134RPS6KB20.45792665
135CDK90.44894674
136MATK0.43341637
137CSNK1A1L0.41474272
138CDC42BPA0.41337794
139FYN0.41171172
140CSNK1G30.40957314
141MAPK70.39949678
142FES0.39293161
143PDK20.38854851
144DYRK1A0.38483839
145PINK10.38344145
146MAPKAPK50.37976960
147SGK30.37877657
148PRKD20.36469314
149HCK0.35380337
150RPS6KB10.33507717

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.03127838
2Synaptic vesicle cycle_Homo sapiens_hsa047212.77559194
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.40552196
4Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.28594866
5B cell receptor signaling pathway_Homo sapiens_hsa046622.07098804
6Circadian entrainment_Homo sapiens_hsa047132.05984096
7Nicotine addiction_Homo sapiens_hsa050332.00092926
8Long-term potentiation_Homo sapiens_hsa047201.99825632
9GABAergic synapse_Homo sapiens_hsa047271.92622142
10Salivary secretion_Homo sapiens_hsa049701.91473064
11Glutamatergic synapse_Homo sapiens_hsa047241.89088294
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.86010724
13Dopaminergic synapse_Homo sapiens_hsa047281.85308064
14Insulin secretion_Homo sapiens_hsa049111.78607840
15Morphine addiction_Homo sapiens_hsa050321.73912959
16Gastric acid secretion_Homo sapiens_hsa049711.72854106
17Amphetamine addiction_Homo sapiens_hsa050311.70743001
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69613515
19Cholinergic synapse_Homo sapiens_hsa047251.66443898
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.65844664
21Adherens junction_Homo sapiens_hsa045201.59127701
22Taste transduction_Homo sapiens_hsa047421.55511576
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.54930304
24Dorso-ventral axis formation_Homo sapiens_hsa043201.41895708
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41771323
26Oxytocin signaling pathway_Homo sapiens_hsa049211.41309087
27Renin secretion_Homo sapiens_hsa049241.40749610
28GnRH signaling pathway_Homo sapiens_hsa049121.40497904
29Gap junction_Homo sapiens_hsa045401.40375264
30Notch signaling pathway_Homo sapiens_hsa043301.37848587
31Histidine metabolism_Homo sapiens_hsa003401.36451343
32Long-term depression_Homo sapiens_hsa047301.33533535
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33194906
34Serotonergic synapse_Homo sapiens_hsa047261.33044506
35T cell receptor signaling pathway_Homo sapiens_hsa046601.33010166
36Axon guidance_Homo sapiens_hsa043601.32956305
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29891567
38Acute myeloid leukemia_Homo sapiens_hsa052211.26963317
39Cocaine addiction_Homo sapiens_hsa050301.26948056
40Estrogen signaling pathway_Homo sapiens_hsa049151.26277152
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21862221
42Phenylalanine metabolism_Homo sapiens_hsa003601.21284030
43Glioma_Homo sapiens_hsa052141.18982045
44Hepatitis C_Homo sapiens_hsa051601.17087262
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14195962
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.14137004
47Dilated cardiomyopathy_Homo sapiens_hsa054141.13925891
48Calcium signaling pathway_Homo sapiens_hsa040201.12576201
49Vibrio cholerae infection_Homo sapiens_hsa051101.12535303
50Melanogenesis_Homo sapiens_hsa049161.10541490
51Viral myocarditis_Homo sapiens_hsa054161.10262839
52Collecting duct acid secretion_Homo sapiens_hsa049661.09388714
53Pancreatic cancer_Homo sapiens_hsa052121.09100279
54Chronic myeloid leukemia_Homo sapiens_hsa052201.08632716
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08518791
56cAMP signaling pathway_Homo sapiens_hsa040241.08158197
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07852045
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05226920
59ErbB signaling pathway_Homo sapiens_hsa040121.04596025
60Cardiac muscle contraction_Homo sapiens_hsa042601.02993084
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97834871
62Vascular smooth muscle contraction_Homo sapiens_hsa042700.96645794
63VEGF signaling pathway_Homo sapiens_hsa043700.95930606
64Tight junction_Homo sapiens_hsa045300.94877668
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94480298
66Prolactin signaling pathway_Homo sapiens_hsa049170.91342191
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90988748
68Chemokine signaling pathway_Homo sapiens_hsa040620.90473330
69Thyroid hormone synthesis_Homo sapiens_hsa049180.90200308
70Endocytosis_Homo sapiens_hsa041440.88636070
71Pancreatic secretion_Homo sapiens_hsa049720.88559759
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.87033655
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.84418388
74Endometrial cancer_Homo sapiens_hsa052130.84356066
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84295748
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83374928
77Type II diabetes mellitus_Homo sapiens_hsa049300.82267416
78Prostate cancer_Homo sapiens_hsa052150.81719988
79Oocyte meiosis_Homo sapiens_hsa041140.80761568
80Renal cell carcinoma_Homo sapiens_hsa052110.79870408
81Osteoclast differentiation_Homo sapiens_hsa043800.79763096
82beta-Alanine metabolism_Homo sapiens_hsa004100.77639804
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76272582
84Rap1 signaling pathway_Homo sapiens_hsa040150.75892267
85MAPK signaling pathway_Homo sapiens_hsa040100.74876019
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.74695861
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74024637
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73596467
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71925846
90Phototransduction_Homo sapiens_hsa047440.70411909
91Inositol phosphate metabolism_Homo sapiens_hsa005620.69150657
92Ras signaling pathway_Homo sapiens_hsa040140.68930712
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68699074
94Circadian rhythm_Homo sapiens_hsa047100.67586234
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67167328
96mTOR signaling pathway_Homo sapiens_hsa041500.67017776
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66444527
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65950802
99Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65046989
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63347367
101Insulin signaling pathway_Homo sapiens_hsa049100.63096771
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62579905
103Choline metabolism in cancer_Homo sapiens_hsa052310.62547493
104Glucagon signaling pathway_Homo sapiens_hsa049220.61646097
105Influenza A_Homo sapiens_hsa051640.59817599
106Tuberculosis_Homo sapiens_hsa051520.59491090
107FoxO signaling pathway_Homo sapiens_hsa040680.59297364
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58980542
109Hippo signaling pathway_Homo sapiens_hsa043900.58073849
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57689984
111Focal adhesion_Homo sapiens_hsa045100.57536759
112Salmonella infection_Homo sapiens_hsa051320.56585233
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56255411
114Hedgehog signaling pathway_Homo sapiens_hsa043400.54403846
115Bile secretion_Homo sapiens_hsa049760.54196274
116Amoebiasis_Homo sapiens_hsa051460.52050813
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51252526
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51097702
119Melanoma_Homo sapiens_hsa052180.50572686
120Proteoglycans in cancer_Homo sapiens_hsa052050.49219617
121Mineral absorption_Homo sapiens_hsa049780.48872285
122Thyroid cancer_Homo sapiens_hsa052160.48593534
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.48253902
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47527509
125Non-small cell lung cancer_Homo sapiens_hsa052230.46420396
126Wnt signaling pathway_Homo sapiens_hsa043100.44915148
127ECM-receptor interaction_Homo sapiens_hsa045120.44894892
128Bladder cancer_Homo sapiens_hsa052190.44673047
129Prion diseases_Homo sapiens_hsa050200.44188836
130Fatty acid biosynthesis_Homo sapiens_hsa000610.41580047
131Platelet activation_Homo sapiens_hsa046110.40886567
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40851697
133Colorectal cancer_Homo sapiens_hsa052100.40544397

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