TTC9B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95323555
2synaptic vesicle exocytosis (GO:0016079)5.92569643
3synaptic vesicle maturation (GO:0016188)5.88894353
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.47857586
5vocalization behavior (GO:0071625)5.47004924
6glutamate secretion (GO:0014047)5.45270262
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.42808722
8protein localization to synapse (GO:0035418)5.41777426
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.39783559
10regulation of synaptic vesicle exocytosis (GO:2000300)5.20501870
11neuron cell-cell adhesion (GO:0007158)5.08172222
12locomotory exploration behavior (GO:0035641)5.06287317
13neuronal action potential propagation (GO:0019227)4.97462618
14regulation of glutamate receptor signaling pathway (GO:1900449)4.80620379
15layer formation in cerebral cortex (GO:0021819)4.64347076
16pyrimidine nucleobase catabolic process (GO:0006208)4.58450505
17regulation of synaptic vesicle transport (GO:1902803)4.55925767
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.53755755
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.44811122
20exploration behavior (GO:0035640)4.42885141
21neurotransmitter secretion (GO:0007269)4.39544145
22regulation of neuronal synaptic plasticity (GO:0048168)4.28961127
23dendritic spine morphogenesis (GO:0060997)4.28240608
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.27302438
25establishment of mitochondrion localization (GO:0051654)4.25189883
26neuron recognition (GO:0008038)4.20547736
27glutamate receptor signaling pathway (GO:0007215)4.13796200
28neuronal ion channel clustering (GO:0045161)4.13719291
29synaptic transmission, glutamatergic (GO:0035249)4.09508225
30regulation of synapse structural plasticity (GO:0051823)4.02037643
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.97334743
32axonal fasciculation (GO:0007413)3.91913582
33neuron-neuron synaptic transmission (GO:0007270)3.85244274
34nucleobase catabolic process (GO:0046113)3.84550075
35regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.79150771
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.78977887
37cell migration in hindbrain (GO:0021535)3.78709168
38cerebellar granule cell differentiation (GO:0021707)3.77981699
39proline transport (GO:0015824)3.75910341
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73161562
41neurotransmitter-gated ion channel clustering (GO:0072578)3.72317083
42positive regulation of membrane potential (GO:0045838)3.72069810
43regulation of dendritic spine morphogenesis (GO:0061001)3.69427613
44positive regulation of synapse maturation (GO:0090129)3.67644213
45postsynaptic membrane organization (GO:0001941)3.66942001
46sodium ion export (GO:0071436)3.65728054
47long-term memory (GO:0007616)3.61544656
48regulation of postsynaptic membrane potential (GO:0060078)3.58828714
49regulation of vesicle fusion (GO:0031338)3.57014166
50activation of protein kinase A activity (GO:0034199)3.56002760
51gamma-aminobutyric acid transport (GO:0015812)3.55412385
52regulation of neurotransmitter secretion (GO:0046928)3.55242584
53establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.52059269
54mitochondrion transport along microtubule (GO:0047497)3.52059269
55neurotransmitter transport (GO:0006836)3.51840249
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.48176179
57neuromuscular synaptic transmission (GO:0007274)3.48045195
58regulation of synaptic plasticity (GO:0048167)3.47548460
59synaptic vesicle endocytosis (GO:0048488)3.44792543
60presynaptic membrane assembly (GO:0097105)3.42691847
61central nervous system myelination (GO:0022010)3.39789667
62axon ensheathment in central nervous system (GO:0032291)3.39789667
63neurofilament cytoskeleton organization (GO:0060052)3.37998335
64gamma-aminobutyric acid signaling pathway (GO:0007214)3.37519240
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.35880990
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35219964
67regulation of dendritic spine development (GO:0060998)3.31923026
68positive regulation of dendritic spine development (GO:0060999)3.31207232
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29344356
70positive regulation of neurotransmitter secretion (GO:0001956)3.27103541
71cellular potassium ion homeostasis (GO:0030007)3.26363101
72presynaptic membrane organization (GO:0097090)3.25569641
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24582241
74transmission of nerve impulse (GO:0019226)3.23542432
75regulation of neurotransmitter levels (GO:0001505)3.23016487
76negative regulation of microtubule polymerization (GO:0031115)3.22495009
77dendrite morphogenesis (GO:0048813)3.22332744
78positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21784041
79adult walking behavior (GO:0007628)3.21288958
80regulation of neurotransmitter transport (GO:0051588)3.19122291
81mechanosensory behavior (GO:0007638)3.17496401
82long-term synaptic potentiation (GO:0060291)3.16642944
83behavioral response to nicotine (GO:0035095)3.16479060
84neuromuscular process controlling balance (GO:0050885)3.14476156
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.14272647
86regulation of synaptic transmission, glutamatergic (GO:0051966)3.13823895
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12046996
88potassium ion homeostasis (GO:0055075)3.11360404
89positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09752244
90membrane depolarization (GO:0051899)3.09097865
91negative regulation of dendrite development (GO:2000171)3.08538671
92positive regulation of neurotransmitter transport (GO:0051590)3.08135305
93adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06786396
94negative regulation of dendrite morphogenesis (GO:0050774)3.05982670
95L-amino acid import (GO:0043092)3.04683448
96auditory behavior (GO:0031223)3.04016917
97behavioral defense response (GO:0002209)3.03413504
98behavioral fear response (GO:0001662)3.03413504
99cerebellar Purkinje cell differentiation (GO:0021702)3.03165144
100dendritic spine organization (GO:0097061)3.01927109
101synapse assembly (GO:0007416)3.01310813
102membrane hyperpolarization (GO:0060081)3.00706484
103learning (GO:0007612)2.98821315
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.97353099
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97293606
106regulation of glutamate secretion (GO:0014048)2.96721539
107innervation (GO:0060384)2.95681655
108regulation of synaptic transmission (GO:0050804)2.95476405
109synaptic transmission (GO:0007268)2.94949497
110fear response (GO:0042596)2.94909057
111social behavior (GO:0035176)2.94094819
112intraspecies interaction between organisms (GO:0051703)2.94094819
113positive regulation of synapse assembly (GO:0051965)2.93911608
114synaptic vesicle transport (GO:0048489)2.93485528
115establishment of synaptic vesicle localization (GO:0097480)2.93485528
116response to auditory stimulus (GO:0010996)2.92319829
117membrane depolarization during action potential (GO:0086010)2.90935550
118behavioral response to cocaine (GO:0048148)2.90763091
119regulation of voltage-gated calcium channel activity (GO:1901385)2.90404636
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88237118
121regulation of synapse maturation (GO:0090128)2.87857255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.69974764
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.42746796
3GBX2_23144817_ChIP-Seq_PC3_Human3.36429215
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.34930527
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16687747
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.95071359
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.94804004
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.94804004
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.87930938
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.87051159
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.74150366
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.69952954
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68806132
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63767978
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63230574
16* RARB_27405468_Chip-Seq_BRAIN_Mouse2.56572145
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.50542641
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.48269179
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.42703912
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36703105
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.33676679
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.33430804
23DROSHA_22980978_ChIP-Seq_HELA_Human2.23691083
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19999156
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.19502994
26AR_21572438_ChIP-Seq_LNCaP_Human1.96867028
27TAF15_26573619_Chip-Seq_HEK293_Human1.94773751
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.90990636
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85434469
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80820162
31* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80690665
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76647137
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.69731587
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60850616
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59313594
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56943403
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56908907
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50578800
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.47389998
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46958243
41ZNF274_21170338_ChIP-Seq_K562_Hela1.46258014
42SMAD4_21799915_ChIP-Seq_A2780_Human1.45216350
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39244524
44* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38636591
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36440862
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36079995
47P300_19829295_ChIP-Seq_ESCs_Human1.33959670
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33030324
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.30477564
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26977777
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26626189
52RNF2_27304074_Chip-Seq_NSC_Mouse1.25166349
53IGF1R_20145208_ChIP-Seq_DFB_Human1.24674894
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.23907735
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.23439704
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21586559
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20022436
58* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19652811
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.18407931
60AR_25329375_ChIP-Seq_VCAP_Human1.16332195
61* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.15509291
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13106925
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09055943
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08013823
65AR_19668381_ChIP-Seq_PC3_Human1.07382245
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07271333
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06781765
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06496624
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06414038
70KDM2B_26808549_Chip-Seq_K562_Human1.05906621
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05361237
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02751233
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02679183
74STAT3_23295773_ChIP-Seq_U87_Human1.02082382
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00834628
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.00538527
77OCT4_19829295_ChIP-Seq_ESCs_Human0.99704622
78* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98053844
79ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97528074
80VDR_22108803_ChIP-Seq_LS180_Human0.96523698
81* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95975390
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.94964761
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94726665
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94138464
85FUS_26573619_Chip-Seq_HEK293_Human0.92947536
86ARNT_22903824_ChIP-Seq_MCF-7_Human0.92350939
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92332692
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.92309740
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.91422673
90CTCF_27219007_Chip-Seq_Bcells_Human0.91356183
91JUN_21703547_ChIP-Seq_K562_Human0.91071070
92TCF4_23295773_ChIP-Seq_U87_Human0.90948793
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90754678
94CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90191532
95RUNX2_22187159_ChIP-Seq_PCA_Human0.90023477
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89397693
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89397693
98TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88955307
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.87495346
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86283648
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85170594
102AHR_22903824_ChIP-Seq_MCF-7_Human0.84632048
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83923521
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82666401
105POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82439300
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82317652
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.81896400
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81619751
109* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81457744
110SMAD_19615063_ChIP-ChIP_OVARY_Human0.80393615
111KLF4_19829295_ChIP-Seq_ESCs_Human0.79092719
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77551563
113DPY_21335234_ChIP-Seq_ESCs_Mouse0.74975854
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.74273757
115* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73042923
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71259799
117SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.70824997
118SMC4_20622854_ChIP-Seq_HELA_Human0.69790385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23570461
2MP0003880_abnormal_central_pattern5.04929944
3MP0003635_abnormal_synaptic_transmissio4.09574614
4MP0004270_analgesia4.00669389
5MP0002063_abnormal_learning/memory/cond3.34953528
6MP0009745_abnormal_behavioral_response3.31967583
7MP0001968_abnormal_touch/_nociception3.21315009
8MP0002064_seizures3.09508059
9MP0009046_muscle_twitch2.97108634
10MP0002734_abnormal_mechanical_nocicepti2.85223614
11MP0005423_abnormal_somatic_nervous2.83674483
12MP0002572_abnormal_emotion/affect_behav2.80410066
13MP0002735_abnormal_chemical_nociception2.73819538
14MP0002272_abnormal_nervous_system2.62148299
15MP0001486_abnormal_startle_reflex2.54025457
16MP0002736_abnormal_nociception_after2.52455758
17MP0002733_abnormal_thermal_nociception2.45386009
18MP0001440_abnormal_grooming_behavior2.26804735
19MP0001970_abnormal_pain_threshold2.25978670
20MP0006276_abnormal_autonomic_nervous2.24476385
21MP0000778_abnormal_nervous_system2.18208142
22MP0002184_abnormal_innervation2.08461684
23MP0002067_abnormal_sensory_capabilities2.00471411
24MP0002822_catalepsy1.98587875
25MP0001501_abnormal_sleep_pattern1.97597270
26MP0003329_amyloid_beta_deposits1.96651162
27MP0004858_abnormal_nervous_system1.93941205
28MP0002557_abnormal_social/conspecific_i1.85491839
29MP0003123_paternal_imprinting1.84778459
30MP0004811_abnormal_neuron_physiology1.81350436
31MP0000955_abnormal_spinal_cord1.74307228
32MP0008569_lethality_at_weaning1.72820884
33MP0005386_behavior/neurological_phenoty1.69093036
34MP0004924_abnormal_behavior1.69093036
35MP0001984_abnormal_olfaction1.65984268
36MP0003879_abnormal_hair_cell1.63468617
37MP0004142_abnormal_muscle_tone1.63325577
38MP0009780_abnormal_chondrocyte_physiolo1.61856383
39MP0003121_genomic_imprinting1.59501785
40MP0008877_abnormal_DNA_methylation1.56846275
41MP0002882_abnormal_neuron_morphology1.52358958
42MP0001529_abnormal_vocalization1.47809816
43MP0002909_abnormal_adrenal_gland1.45899404
44MP0002066_abnormal_motor_capabilities/c1.45432981
45MP0001905_abnormal_dopamine_level1.35462024
46MP0003122_maternal_imprinting1.29557720
47MP0001502_abnormal_circadian_rhythm1.27315780
48MP0001986_abnormal_taste_sensitivity1.27050217
49MP0000751_myopathy1.23013411
50MP0004885_abnormal_endolymph1.19769523
51MP0003633_abnormal_nervous_system1.18089224
52MP0002152_abnormal_brain_morphology1.17901521
53MP0005645_abnormal_hypothalamus_physiol1.16360680
54MP0004742_abnormal_vestibular_system1.12475009
55MP0005646_abnormal_pituitary_gland1.12314109
56MP0004145_abnormal_muscle_electrophysio1.07013573
57MP0003631_nervous_system_phenotype1.02827936
58MP0001188_hyperpigmentation1.02344446
59MP0003787_abnormal_imprinting1.01506992
60MP0010386_abnormal_urinary_bladder1.01030740
61MP0002069_abnormal_eating/drinking_beha0.96666274
62MP0002229_neurodegeneration0.95466608
63MP0005499_abnormal_olfactory_system0.94419859
64MP0005394_taste/olfaction_phenotype0.94419859
65MP0002752_abnormal_somatic_nervous0.92468502
66MP0001963_abnormal_hearing_physiology0.88801867
67MP0008872_abnormal_physiological_respon0.88516534
68MP0008874_decreased_physiological_sensi0.88209361
69MP0002837_dystrophic_cardiac_calcinosis0.87364927
70MP0003690_abnormal_glial_cell0.86171531
71MP0005551_abnormal_eye_electrophysiolog0.86077258
72MP0000604_amyloidosis0.84148938
73MP0003634_abnormal_glial_cell0.82788102
74MP0002653_abnormal_ependyma_morphology0.82669239
75MP0006292_abnormal_olfactory_placode0.78340327
76MP0000631_abnormal_neuroendocrine_gland0.77962820
77MP0005535_abnormal_body_temperature0.76943526
78MP0002638_abnormal_pupillary_reflex0.75995364
79MP0004130_abnormal_muscle_cell0.75564250
80MP0004085_abnormal_heartbeat0.75433777
81MP0000920_abnormal_myelination0.75276469
82MP0000569_abnormal_digit_pigmentation0.74137740
83MP0001664_abnormal_digestion0.72921627
84MP0003861_abnormal_nervous_system0.72586908
85MP0001485_abnormal_pinna_reflex0.72219065
86MP0003632_abnormal_nervous_system0.68618030
87MP0005623_abnormal_meninges_morphology0.67975555
88MP0005409_darkened_coat_color0.67706414
89MP0001177_atelectasis0.67306682
90MP0002751_abnormal_autonomic_nervous0.64763663
91MP0000013_abnormal_adipose_tissue0.62626951
92MP0004510_myositis0.60596725
93MP0004133_heterotaxia0.59795168
94MP0003075_altered_response_to0.59564925
95MP0001348_abnormal_lacrimal_gland0.59067236
96MP0000026_abnormal_inner_ear0.59047793
97MP0002876_abnormal_thyroid_physiology0.58705358
98MP0001943_abnormal_respiration0.58677855
99MP0002090_abnormal_vision0.57162486
100MP0003137_abnormal_impulse_conducting0.56721045
101MP0002160_abnormal_reproductive_system0.54421361
102MP0010769_abnormal_survival0.54334794
103MP0004484_altered_response_of0.54295214
104MP0002082_postnatal_lethality0.54086911
105MP0010770_preweaning_lethality0.54086911
106MP0008789_abnormal_olfactory_epithelium0.53200290
107MP0002102_abnormal_ear_morphology0.53162356
108MP0005167_abnormal_blood-brain_barrier0.52514750
109MP0008961_abnormal_basal_metabolism0.52222251
110MP0003956_abnormal_body_size0.51243453
111MP0010768_mortality/aging0.51129321
112MP0003938_abnormal_ear_development0.50453141
113MP0004043_abnormal_pH_regulation0.47992092
114MP0003283_abnormal_digestive_organ0.46419846

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.35577537
2Focal motor seizures (HP:0011153)7.33068499
3Focal seizures (HP:0007359)5.64504216
4Visual hallucinations (HP:0002367)5.54080149
5Epileptic encephalopathy (HP:0200134)4.82416674
6Atonic seizures (HP:0010819)4.68833570
7Febrile seizures (HP:0002373)4.30495928
8Absence seizures (HP:0002121)4.22455311
9Progressive cerebellar ataxia (HP:0002073)4.19681146
10Dialeptic seizures (HP:0011146)3.76918605
11Generalized tonic-clonic seizures (HP:0002069)3.76627730
12Supranuclear gaze palsy (HP:0000605)3.75790629
13Amblyopia (HP:0000646)3.60468723
14Action tremor (HP:0002345)3.49991793
15Broad-based gait (HP:0002136)3.44871850
16Ankle clonus (HP:0011448)3.35100336
17Poor eye contact (HP:0000817)3.31223874
18Mutism (HP:0002300)3.15157355
19Impaired vibration sensation in the lower limbs (HP:0002166)3.14355766
20Limb dystonia (HP:0002451)3.08873462
21Cerebral hypomyelination (HP:0006808)3.07175399
22Abnormal eating behavior (HP:0100738)3.00209473
23Depression (HP:0000716)2.92320890
24Abnormal social behavior (HP:0012433)2.86967232
25Impaired social interactions (HP:0000735)2.86967232
26Urinary bladder sphincter dysfunction (HP:0002839)2.85616263
27Gaze-evoked nystagmus (HP:0000640)2.85231790
28Hyperventilation (HP:0002883)2.84997112
29Polyphagia (HP:0002591)2.84991971
30Dysmetria (HP:0001310)2.80498916
31Cerebral inclusion bodies (HP:0100314)2.77270607
32Dysdiadochokinesis (HP:0002075)2.76314003
33Anxiety (HP:0000739)2.75350931
34Excessive salivation (HP:0003781)2.73880816
35Drooling (HP:0002307)2.73880816
36Urinary urgency (HP:0000012)2.68734521
37Neurofibrillary tangles (HP:0002185)2.68517788
38Truncal ataxia (HP:0002078)2.67179454
39Failure to thrive in infancy (HP:0001531)2.66743495
40Epileptiform EEG discharges (HP:0011182)2.60467235
41Papilledema (HP:0001085)2.59659082
42Spastic gait (HP:0002064)2.59612724
43Progressive inability to walk (HP:0002505)2.57468128
44Spastic tetraplegia (HP:0002510)2.56909705
45Abnormality of the corticospinal tract (HP:0002492)2.56360487
46Megalencephaly (HP:0001355)2.56073060
47Hemiparesis (HP:0001269)2.54554877
48Focal dystonia (HP:0004373)2.53940101
49EEG with generalized epileptiform discharges (HP:0011198)2.53898984
50Morphological abnormality of the pyramidal tract (HP:0002062)2.53361998
51Insidious onset (HP:0003587)2.50136794
52Termporal pattern (HP:0011008)2.50136794
53Abnormality of the lower motor neuron (HP:0002366)2.45688093
54Hyperthyroidism (HP:0000836)2.42979196
55Torticollis (HP:0000473)2.42454146
56Stereotypic behavior (HP:0000733)2.41412845
57Absent speech (HP:0001344)2.41151428
58Abnormality of the labia minora (HP:0012880)2.40000523
59Annular pancreas (HP:0001734)2.39632376
60Clonus (HP:0002169)2.39630348
61Hypsarrhythmia (HP:0002521)2.39470084
62Scanning speech (HP:0002168)2.35566855
63Delusions (HP:0000746)2.35333699
64Genetic anticipation (HP:0003743)2.35196429
65Fetal akinesia sequence (HP:0001989)2.34556146
66Amyotrophic lateral sclerosis (HP:0007354)2.33851157
67Inability to walk (HP:0002540)2.29292818
68Sleep apnea (HP:0010535)2.27763952
69Diplopia (HP:0000651)2.27026480
70Abnormality of binocular vision (HP:0011514)2.27026480
71Generalized myoclonic seizures (HP:0002123)2.26069338
72Postural instability (HP:0002172)2.24027319
73Obstructive sleep apnea (HP:0002870)2.22308579
74Impaired smooth pursuit (HP:0007772)2.15974541
75Akinesia (HP:0002304)2.15369643
76Status epilepticus (HP:0002133)2.15151595
77Tetraplegia (HP:0002445)2.14732703
78Peripheral hypomyelination (HP:0007182)2.14723838
79Bradykinesia (HP:0002067)2.13118252
80Specific learning disability (HP:0001328)2.10706735
81Pheochromocytoma (HP:0002666)2.08248167
82Lower limb muscle weakness (HP:0007340)2.05368674
83Craniofacial dystonia (HP:0012179)2.05024493
84Agitation (HP:0000713)2.04338216
85CNS hypomyelination (HP:0003429)2.03011711
86Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02964091
87Hypoplasia of the brainstem (HP:0002365)2.02964091
88Impaired vibratory sensation (HP:0002495)2.02718877
89Gait imbalance (HP:0002141)2.01411167
90Hypoplasia of the corpus callosum (HP:0002079)2.01346945
91Generalized hypotonia (HP:0001290)2.00283411
92Hypoventilation (HP:0002791)1.99109437
93Spastic tetraparesis (HP:0001285)1.99024892
94Poor suck (HP:0002033)1.97792224
95Retinal dysplasia (HP:0007973)1.93016856
96Esotropia (HP:0000565)1.92539030
97Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.90947306
98Pachygyria (HP:0001302)1.90388300
99Incomplete penetrance (HP:0003829)1.88437837
100Psychosis (HP:0000709)1.87390751
101Ventricular fibrillation (HP:0001663)1.87354149
102Rapidly progressive (HP:0003678)1.86643144
103Intention tremor (HP:0002080)1.86642402
104Truncus arteriosus (HP:0001660)1.86491052
105Intellectual disability, severe (HP:0010864)1.84615559
106Diminished motivation (HP:0000745)1.82900580
107Abnormality of salivation (HP:0100755)1.82874086
108Apathy (HP:0000741)1.80955879
109Paraplegia (HP:0010550)1.80417655
110Abnormality of ocular smooth pursuit (HP:0000617)1.79561879
111Hemiplegia (HP:0002301)1.79481122
112Lissencephaly (HP:0001339)1.79387759
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.79287369
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79287369
115Neuronal loss in central nervous system (HP:0002529)1.78850354
116Prolonged QT interval (HP:0001657)1.69458712
117Muscular hypotonia of the trunk (HP:0008936)1.68984961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.13472815
2MAP3K93.77030149
3MARK13.67971756
4NTRK33.67486001
5MAP3K43.12746374
6MINK12.90750844
7DAPK22.69810088
8MAP2K72.68550111
9RIPK42.47006383
10CASK2.26145422
11PAK62.24486329
12MAP3K122.24315392
13ARAF1.98248625
14KSR21.97583948
15MAP2K41.95591840
16NTRK21.83604264
17NTRK11.77382068
18GRK51.75433414
19SIK21.73174436
20CDK191.67199314
21MAPK131.64251247
22KSR11.63760469
23PNCK1.59859038
24PLK21.59226645
25DAPK11.56998819
26PRKD31.56850099
27CDK51.55576722
28CAMKK11.53940007
29UHMK11.35442226
30PRPF4B1.29374239
31PRKCG1.22376954
32LATS21.20514040
33PHKG21.17401315
34PHKG11.17401315
35CAMKK21.13942624
36TNIK1.13391585
37FES1.05064405
38BMPR21.01022985
39CDK181.00661342
40CDK140.99622739
41CDK150.97888410
42MAP3K20.97760825
43TYRO30.97648120
44NME10.96242064
45CAMK2A0.94225896
46LIMK10.91500231
47MAP3K110.90762760
48DYRK1A0.89423631
49CDK11A0.88199690
50MAP3K130.87468594
51RAF10.86646699
52OXSR10.82798308
53PTK2B0.81324929
54PAK30.80101328
55MARK20.79446805
56CAMK10.79229553
57TAOK10.79091578
58STK380.78202900
59CSNK1G20.77111617
60RET0.73327122
61CAMK2B0.73069076
62STK110.71379184
63BRAF0.71205804
64SGK2230.69492568
65SGK4940.69492568
66BRSK10.68800393
67CSNK1A1L0.67652627
68CCNB10.65869762
69DAPK30.63142115
70DYRK20.61101175
71WNK40.59807031
72PRKCZ0.56993583
73PDPK10.54902356
74SGK30.52959078
75PDK10.51516351
76FGR0.51123596
77PRKCE0.50906836
78PKN10.50771231
79MAP4K20.50392641
80LMTK20.50098717
81SGK10.49767768
82MAP3K10.48608040
83BCR0.47759212
84PRKCH0.47618691
85PINK10.47242020
86CSNK1G10.46814244
87CAMK2G0.46752554
88MAP3K60.45097937
89MAP2K10.44694185
90FER0.43806592
91PRKACA0.42296640
92CSNK1E0.42059143
93ROCK20.40985194
94TESK10.39789157
95DYRK1B0.38358982
96RIPK10.38214281
97PRKCA0.37868522
98CAMK40.37576282
99CAMK2D0.36869785
100FYN0.36863501
101NEK60.36024273
102MAPK120.35993084
103RPS6KA20.35741374
104SIK30.35129546
105ALK0.34988948
106TRIM280.34945870
107SCYL20.34741694
108MAPK100.34688413
109ADRBK10.33716353
110RPS6KA30.33681491
111WNK30.33096098
112CSNK1A10.32930571
113MAPK80.32650357
114CAMK1G0.31783226
115CSNK1G30.31555348
116MAPK40.31401332
117SGK20.31021492
118PRKG10.30539067
119CSNK1D0.28683093
120TNK20.26927697
121PRKAA10.26547569
122ERBB20.26294560
123MAPK150.25665887

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53618353
2Synaptic vesicle cycle_Homo sapiens_hsa047213.51135568
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70416878
4Olfactory transduction_Homo sapiens_hsa047402.65793249
5Long-term potentiation_Homo sapiens_hsa047202.64459774
6Circadian entrainment_Homo sapiens_hsa047132.63036666
7GABAergic synapse_Homo sapiens_hsa047272.60631993
8Glutamatergic synapse_Homo sapiens_hsa047242.59547837
9Morphine addiction_Homo sapiens_hsa050322.48493384
10Amphetamine addiction_Homo sapiens_hsa050312.36699823
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.35383472
12Dopaminergic synapse_Homo sapiens_hsa047282.18851434
13Salivary secretion_Homo sapiens_hsa049702.14637885
14Cholinergic synapse_Homo sapiens_hsa047251.97997482
15Insulin secretion_Homo sapiens_hsa049111.97353286
16Taste transduction_Homo sapiens_hsa047421.93533469
17Gastric acid secretion_Homo sapiens_hsa049711.86150247
18Long-term depression_Homo sapiens_hsa047301.76181924
19Serotonergic synapse_Homo sapiens_hsa047261.75681708
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73628551
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71629670
22Collecting duct acid secretion_Homo sapiens_hsa049661.70075526
23Oxytocin signaling pathway_Homo sapiens_hsa049211.69173517
24Renin secretion_Homo sapiens_hsa049241.67299197
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64643046
26Gap junction_Homo sapiens_hsa045401.57230196
27GnRH signaling pathway_Homo sapiens_hsa049121.55431641
28Calcium signaling pathway_Homo sapiens_hsa040201.47394967
29Cocaine addiction_Homo sapiens_hsa050301.46664135
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39666285
31Cardiac muscle contraction_Homo sapiens_hsa042601.37245500
32Axon guidance_Homo sapiens_hsa043601.36691660
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24377465
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21979977
35Glioma_Homo sapiens_hsa052141.14098889
36Vitamin B6 metabolism_Homo sapiens_hsa007501.14026354
37Melanogenesis_Homo sapiens_hsa049161.14004596
38Estrogen signaling pathway_Homo sapiens_hsa049151.13372052
39Oxidative phosphorylation_Homo sapiens_hsa001901.12529410
40cAMP signaling pathway_Homo sapiens_hsa040241.12526727
41ErbB signaling pathway_Homo sapiens_hsa040121.11231032
42Vibrio cholerae infection_Homo sapiens_hsa051101.08280469
43Alzheimers disease_Homo sapiens_hsa050101.05745266
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04564001
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96274686
46Type II diabetes mellitus_Homo sapiens_hsa049300.96252446
47Oocyte meiosis_Homo sapiens_hsa041140.96045141
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92394265
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.92163073
50Phototransduction_Homo sapiens_hsa047440.91709977
51Parkinsons disease_Homo sapiens_hsa050120.91289978
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89762002
53VEGF signaling pathway_Homo sapiens_hsa043700.84454302
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83692056
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83609065
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.82046384
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78217096
58Choline metabolism in cancer_Homo sapiens_hsa052310.77558646
59Pancreatic secretion_Homo sapiens_hsa049720.76259204
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75466189
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74846216
62Dorso-ventral axis formation_Homo sapiens_hsa043200.74296703
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69689284
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.68648040
65MAPK signaling pathway_Homo sapiens_hsa040100.67794465
66Thyroid hormone synthesis_Homo sapiens_hsa049180.67633609
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64557285
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.64117100
69Ras signaling pathway_Homo sapiens_hsa040140.62653774
70Dilated cardiomyopathy_Homo sapiens_hsa054140.61416050
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60769034
72Huntingtons disease_Homo sapiens_hsa050160.57678092
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55727615
74Regulation of autophagy_Homo sapiens_hsa041400.55139718
75Alcoholism_Homo sapiens_hsa050340.55005637
76Rap1 signaling pathway_Homo sapiens_hsa040150.51744227
77Prion diseases_Homo sapiens_hsa050200.50720322
78Endometrial cancer_Homo sapiens_hsa052130.48882734
79Renal cell carcinoma_Homo sapiens_hsa052110.48102219
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47777768
81Wnt signaling pathway_Homo sapiens_hsa043100.46609236
82Glucagon signaling pathway_Homo sapiens_hsa049220.46503471
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45119937
84Endocytosis_Homo sapiens_hsa041440.45044892
85Insulin signaling pathway_Homo sapiens_hsa049100.43514062
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43370030
87Arginine and proline metabolism_Homo sapiens_hsa003300.43315245
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43064601
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42043114
90Non-small cell lung cancer_Homo sapiens_hsa052230.41028499
91African trypanosomiasis_Homo sapiens_hsa051430.39363804
92mTOR signaling pathway_Homo sapiens_hsa041500.39126246
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39067197
94Butanoate metabolism_Homo sapiens_hsa006500.38884151
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38606754
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38470280
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37055048
98Ether lipid metabolism_Homo sapiens_hsa005650.35488371
99Circadian rhythm_Homo sapiens_hsa047100.35379824
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35327024
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33430302
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33410544
103Bile secretion_Homo sapiens_hsa049760.33372609
104Ovarian steroidogenesis_Homo sapiens_hsa049130.32446411
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31487889
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29343642
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28371255
108Colorectal cancer_Homo sapiens_hsa052100.27515318
109beta-Alanine metabolism_Homo sapiens_hsa004100.27163320
110Inositol phosphate metabolism_Homo sapiens_hsa005620.26326590
111Type I diabetes mellitus_Homo sapiens_hsa049400.25950044
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24437048
113Arginine biosynthesis_Homo sapiens_hsa002200.22233203
114Hippo signaling pathway_Homo sapiens_hsa043900.21906342
115Steroid biosynthesis_Homo sapiens_hsa001000.18691364

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