TTF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.36662784
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.11270984
3energy coupled proton transport, down electrochemical gradient (GO:0015985)3.85501728
4ATP synthesis coupled proton transport (GO:0015986)3.85501728
5DNA deamination (GO:0045006)3.80047182
6chaperone-mediated protein transport (GO:0072321)3.79037456
7protein K6-linked ubiquitination (GO:0085020)3.71699881
8telomere maintenance via semi-conservative replication (GO:0032201)3.64970538
9protein complex biogenesis (GO:0070271)3.61538782
10mitochondrial respiratory chain complex assembly (GO:0033108)3.61425697
11behavioral response to nicotine (GO:0035095)3.59628997
12ribosomal small subunit biogenesis (GO:0042274)3.59364827
13kinetochore assembly (GO:0051382)3.55829355
14maturation of SSU-rRNA (GO:0030490)3.55022408
15kinetochore organization (GO:0051383)3.54869986
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54108383
17mitochondrial respiratory chain complex I assembly (GO:0032981)3.54108383
18NADH dehydrogenase complex assembly (GO:0010257)3.54108383
19ribosomal small subunit assembly (GO:0000028)3.52217011
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46943028
21telomere maintenance via recombination (GO:0000722)3.45755400
22DNA strand elongation involved in DNA replication (GO:0006271)3.44597818
23regulation of nuclear cell cycle DNA replication (GO:0033262)3.41220395
24regulation of helicase activity (GO:0051095)3.39916019
25CENP-A containing nucleosome assembly (GO:0034080)3.36683338
26DNA strand elongation (GO:0022616)3.36013094
27chromatin remodeling at centromere (GO:0031055)3.33465841
28DNA double-strand break processing (GO:0000729)3.31112524
29DNA replication initiation (GO:0006270)3.29355737
30water-soluble vitamin biosynthetic process (GO:0042364)3.28834245
31DNA replication checkpoint (GO:0000076)3.27326773
32nonmotile primary cilium assembly (GO:0035058)3.26583782
33mitotic metaphase plate congression (GO:0007080)3.25174613
34mitotic recombination (GO:0006312)3.23964552
35telomere maintenance via telomere lengthening (GO:0010833)3.22910221
36protein neddylation (GO:0045116)3.19015851
37ribosomal large subunit biogenesis (GO:0042273)3.18168941
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.14613708
39regulation of DNA endoreduplication (GO:0032875)3.12079611
40transcription elongation from RNA polymerase III promoter (GO:0006385)3.09444943
41termination of RNA polymerase III transcription (GO:0006386)3.09444943
42recombinational repair (GO:0000725)3.08991615
43histone mRNA metabolic process (GO:0008334)3.08779907
44protein-cofactor linkage (GO:0018065)3.06328004
45rRNA modification (GO:0000154)3.04580509
46double-strand break repair via homologous recombination (GO:0000724)3.03958910
47intra-S DNA damage checkpoint (GO:0031573)3.01613488
48regulation of double-strand break repair via homologous recombination (GO:0010569)3.01080266
49ribonucleoprotein complex biogenesis (GO:0022613)3.00981011
50respiratory electron transport chain (GO:0022904)3.00707948
51transcription-coupled nucleotide-excision repair (GO:0006283)3.00693013
52electron transport chain (GO:0022900)3.00673422
53regulation of mitochondrial translation (GO:0070129)2.99976618
54nucleotide-excision repair, DNA gap filling (GO:0006297)2.96876955
55postreplication repair (GO:0006301)2.96129886
56DNA replication-independent nucleosome organization (GO:0034724)2.95252973
57DNA replication-independent nucleosome assembly (GO:0006336)2.95252973
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95252711
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95252711
60transcription elongation from RNA polymerase I promoter (GO:0006362)2.94970990
61metaphase plate congression (GO:0051310)2.92547168
62poly(A)+ mRNA export from nucleus (GO:0016973)2.92457144
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89203705
64maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89077310
65negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.87775230
66RNA capping (GO:0036260)2.85949761
677-methylguanosine RNA capping (GO:0009452)2.85949761
68mismatch repair (GO:0006298)2.85307210
69DNA ligation (GO:0006266)2.84948348
707-methylguanosine mRNA capping (GO:0006370)2.84498714
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.83997221
72meiotic chromosome segregation (GO:0045132)2.83016612
73telomere maintenance (GO:0000723)2.82634687
74respiratory chain complex IV assembly (GO:0008535)2.82472174
75* termination of RNA polymerase I transcription (GO:0006363)2.81757660
76DNA damage response, detection of DNA damage (GO:0042769)2.80992627
77resolution of meiotic recombination intermediates (GO:0000712)2.80937660
78telomere maintenance via telomerase (GO:0007004)2.80796889
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79589685
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.79589685
81DNA replication-dependent nucleosome organization (GO:0034723)2.79189243
82DNA replication-dependent nucleosome assembly (GO:0006335)2.79189243
83daunorubicin metabolic process (GO:0044597)2.79011050
84polyketide metabolic process (GO:0030638)2.79011050
85doxorubicin metabolic process (GO:0044598)2.79011050
86telomere organization (GO:0032200)2.78717678
87rRNA processing (GO:0006364)2.77590070
88RNA-dependent DNA replication (GO:0006278)2.77419293
89DNA catabolic process, exonucleolytic (GO:0000738)2.75276493
90inner mitochondrial membrane organization (GO:0007007)2.75222926
91somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75201913
92somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75201913
93isotype switching (GO:0045190)2.75201913
94histone exchange (GO:0043486)2.74834529
95* transcription from RNA polymerase I promoter (GO:0006360)2.74831464
96establishment of chromosome localization (GO:0051303)2.72901391
97negative regulation of DNA recombination (GO:0045910)2.72466141
98ribosome biogenesis (GO:0042254)2.70346681
99rRNA methylation (GO:0031167)2.69776436
100cotranslational protein targeting to membrane (GO:0006613)2.69208383
101termination of RNA polymerase II transcription (GO:0006369)2.69129611
102cytochrome complex assembly (GO:0017004)2.68967035
103rRNA metabolic process (GO:0016072)2.68851884
104regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.68566517
105regulation of mitotic spindle checkpoint (GO:1903504)2.68566517
106regulation of centriole replication (GO:0046599)2.67773793
107regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67766866
108centriole assembly (GO:0098534)2.67425731
109attachment of spindle microtubules to kinetochore (GO:0008608)2.66757140
110somatic recombination of immunoglobulin gene segments (GO:0016447)2.64933014
111protein localization to kinetochore (GO:0034501)2.64775654
112regulation of cilium movement (GO:0003352)2.64219977
113protein targeting to ER (GO:0045047)2.63475384
114viral transcription (GO:0019083)2.63020151
115DNA-dependent DNA replication (GO:0006261)2.61830985
116transcription from RNA polymerase III promoter (GO:0006383)2.61569586
117establishment of integrated proviral latency (GO:0075713)2.60680304
118DNA strand renaturation (GO:0000733)2.60548093
119cullin deneddylation (GO:0010388)2.60232888
120cellular component biogenesis (GO:0044085)2.59136503
121protein deneddylation (GO:0000338)2.58748328
122microtubule depolymerization (GO:0007019)2.57940732
123replication fork processing (GO:0031297)2.57330721
124translation (GO:0006412)2.56905624
125mitochondrial RNA metabolic process (GO:0000959)2.56871804
126positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.56580645
127centriole replication (GO:0007099)2.56549116
128tRNA processing (GO:0008033)2.56004900
129DNA synthesis involved in DNA repair (GO:0000731)2.55473481
130translational termination (GO:0006415)2.53162867
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53140904
132transcription elongation from RNA polymerase II promoter (GO:0006368)2.52023424
133somatic diversification of immunoglobulins (GO:0016445)2.50585931
134nucleobase biosynthetic process (GO:0046112)2.49667734
135purine nucleobase biosynthetic process (GO:0009113)2.49131817
136nucleotide-excision repair (GO:0006289)2.48305175
137nuclear pore organization (GO:0006999)2.47851375
138nuclear pore complex assembly (GO:0051292)2.47693824
139somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.47438099
140somatic cell DNA recombination (GO:0016444)2.47438099
141spliceosomal snRNP assembly (GO:0000387)2.46390152
142positive regulation of gamma-delta T cell activation (GO:0046645)2.45760318
143maturation of 5.8S rRNA (GO:0000460)2.45223192
144* transcription initiation from RNA polymerase I promoter (GO:0006361)2.44979870
145nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44885708
146DNA-templated transcription, elongation (GO:0006354)2.43878632
147* DNA-templated transcription, termination (GO:0006353)2.43762993
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41796040
149negative regulation of telomere maintenance (GO:0032205)2.41595118
150proteasome assembly (GO:0043248)2.40819713
151pseudouridine synthesis (GO:0001522)2.40626616
152somatic diversification of immune receptors (GO:0002200)2.38774871
153DNA replication (GO:0006260)2.38670851
154reciprocal DNA recombination (GO:0035825)2.38084036

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30684621
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45563023
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43437132
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.08478588
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.06691502
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.97470045
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83835686
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.82840295
9* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78976256
10EZH2_22144423_ChIP-Seq_EOC_Human2.74914320
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.70762203
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70580464
13ZNF274_21170338_ChIP-Seq_K562_Hela2.57280835
14VDR_23849224_ChIP-Seq_CD4+_Human2.38268597
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.36086752
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35057451
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.32929559
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.26061802
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.22777596
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15576608
21ELK1_19687146_ChIP-ChIP_HELA_Human2.14765633
22* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12213256
23FOXP3_21729870_ChIP-Seq_TREG_Human2.09156243
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.08426898
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03965446
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02952558
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00042952
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98648090
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.98428326
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.98337632
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98244462
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95754220
33EWS_26573619_Chip-Seq_HEK293_Human1.94682128
34* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94425856
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.93475874
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90144846
37VDR_22108803_ChIP-Seq_LS180_Human1.89131643
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.83391379
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.78540098
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78157402
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78146890
42TP63_19390658_ChIP-ChIP_HaCaT_Human1.76560183
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75173960
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72324352
45FUS_26573619_Chip-Seq_HEK293_Human1.72077856
46IGF1R_20145208_ChIP-Seq_DFB_Human1.70547562
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.69667401
48* SRF_21415370_ChIP-Seq_HL-1_Mouse1.68913331
49* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63848135
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60990983
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.60925988
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59719315
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52687325
54* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52233980
55XRN2_22483619_ChIP-Seq_HELA_Human1.52089480
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52067870
57* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51366318
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49591523
59DCP1A_22483619_ChIP-Seq_HELA_Human1.48897901
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48531438
61TTF2_22483619_ChIP-Seq_HELA_Human1.46432291
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44935803
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44445389
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.42518419
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40248728
66SPI1_23547873_ChIP-Seq_NB4_Human1.38112878
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34904675
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31910924
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31632100
70GABP_19822575_ChIP-Seq_HepG2_Human1.30486765
71ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30340054
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28501818
73* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27955527
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27732191
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.27112377
76TAF15_26573619_Chip-Seq_HEK293_Human1.26593171
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26395937
78POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25719681
79P300_19829295_ChIP-Seq_ESCs_Human1.24856241
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23707535
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.23209080
82IRF1_19129219_ChIP-ChIP_H3396_Human1.22910111
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22349001
84TP53_22573176_ChIP-Seq_HFKS_Human1.21227217
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18987106
86MYC_18940864_ChIP-ChIP_HL60_Human1.18851724
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17222605
88CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16766810
89CIITA_25753668_ChIP-Seq_RAJI_Human1.14938122
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13973016
91* NANOG_16153702_ChIP-ChIP_HESCs_Human1.10495600
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09919065
93* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09251319
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08275750
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.08266636
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08105771
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06991681
98FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06247498
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06201973
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05904857
101RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02365542
102KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01783851
103SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00066694
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99137326
105* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98868420
106KDM5A_27292631_Chip-Seq_BREAST_Human0.98164785
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97539805
108AR_21909140_ChIP-Seq_LNCAP_Human0.96886548
109GBX2_23144817_ChIP-Seq_PC3_Human0.95075691
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94973943
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94351363
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94351363
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94351363
114* MYB_26560356_Chip-Seq_TH1_Human0.93787565
115BP1_19119308_ChIP-ChIP_Hs578T_Human0.92804187
116MYB_26560356_Chip-Seq_TH2_Human0.91816773
117TFEB_21752829_ChIP-Seq_HELA_Human0.91615320
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.90095315
119GATA1_22025678_ChIP-Seq_K562_Human0.89801113
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89582512
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89571970
122STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.87706535
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.86805950
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85850989
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85435998
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82743425
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81297229
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80364419
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79221485
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.79221485
131RNF2_27304074_Chip-Seq_NSC_Mouse0.77106708
132CBP_20019798_ChIP-Seq_JUKART_Human0.76974872
133IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76974872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.70960831
2MP0008058_abnormal_DNA_repair3.66035671
3MP0003693_abnormal_embryo_hatching3.61611367
4MP0008057_abnormal_DNA_replication3.44919764
5MP0003111_abnormal_nucleus_morphology3.17882815
6MP0008789_abnormal_olfactory_epithelium3.05166363
7MP0003136_yellow_coat_color2.76770231
8MP0003077_abnormal_cell_cycle2.66278071
9MP0008007_abnormal_cellular_replicative2.51109179
10MP0008877_abnormal_DNA_methylation2.46583915
11MP0005394_taste/olfaction_phenotype2.45687989
12MP0005499_abnormal_olfactory_system2.45687989
13MP0003890_abnormal_embryonic-extraembry2.29241544
14MP0001835_abnormal_antigen_presentation2.23333308
15MP0003763_abnormal_thymus_physiology2.21968300
16MP0006292_abnormal_olfactory_placode2.17235679
17MP0001529_abnormal_vocalization2.15561595
18MP0005671_abnormal_response_to2.13550848
19MP0001968_abnormal_touch/_nociception2.10309352
20MP0002396_abnormal_hematopoietic_system2.05306817
21MP0004957_abnormal_blastocyst_morpholog2.04084260
22MP0003786_premature_aging1.98360362
23MP0002736_abnormal_nociception_after1.98193880
24MP0001986_abnormal_taste_sensitivity1.98132209
25MP0001984_abnormal_olfaction1.96034354
26MP0003941_abnormal_skin_development1.86671282
27MP0009785_altered_susceptibility_to1.79199422
28MP0004381_abnormal_hair_follicle1.72930695
29MP0001800_abnormal_humoral_immune1.72440360
30MP0000566_synostosis1.69684447
31MP0002132_abnormal_respiratory_system1.68247942
32MP0002837_dystrophic_cardiac_calcinosis1.62999574
33MP0002653_abnormal_ependyma_morphology1.62437592
34MP0009333_abnormal_splenocyte_physiolog1.58305336
35MP0000685_abnormal_immune_system1.57574631
36MP0005174_abnormal_tail_pigmentation1.55705804
37MP0003121_genomic_imprinting1.55154855
38MP0002234_abnormal_pharynx_morphology1.54288986
39MP0006072_abnormal_retinal_apoptosis1.53843714
40MP0002638_abnormal_pupillary_reflex1.53715963
41MP0008932_abnormal_embryonic_tissue1.53404640
42MP0002723_abnormal_immune_serum1.52756204
43MP0001790_abnormal_immune_system1.52610688
44MP0005387_immune_system_phenotype1.52610688
45MP0006276_abnormal_autonomic_nervous1.51608706
46MP0002452_abnormal_antigen_presenting1.51162344
47MP0002398_abnormal_bone_marrow1.50082399
48MP0002420_abnormal_adaptive_immunity1.48120158
49MP0001819_abnormal_immune_cell1.47872593
50MP0002277_abnormal_respiratory_mucosa1.47381286
51MP0002148_abnormal_hypersensitivity_rea1.46339878
52MP0003646_muscle_fatigue1.44038378
53MP0005000_abnormal_immune_tolerance1.42470228
54MP0005075_abnormal_melanosome_morpholog1.40168920
55MP0001485_abnormal_pinna_reflex1.39453439
56MP0000569_abnormal_digit_pigmentation1.39404586
57MP0000490_abnormal_crypts_of1.36623943
58MP0003011_delayed_dark_adaptation1.36499105
59MP0005025_abnormal_response_to1.36227199
60MP0001188_hyperpigmentation1.35849242
61MP0004133_heterotaxia1.35236824
62MP0005551_abnormal_eye_electrophysiolog1.35134033
63MP0000716_abnormal_immune_system1.33213728
64MP0000689_abnormal_spleen_morphology1.29077061
65MP0000703_abnormal_thymus_morphology1.28678356
66MP0002405_respiratory_system_inflammati1.28247022
67MP0000015_abnormal_ear_pigmentation1.27368795
68MP0006035_abnormal_mitochondrial_morpho1.26617917
69MP0002210_abnormal_sex_determination1.26027099
70MP0005084_abnormal_gallbladder_morpholo1.25900074
71MP0002722_abnormal_immune_system1.25720077
72MP0002419_abnormal_innate_immunity1.25106344
73MP0002095_abnormal_skin_pigmentation1.23389664
74MP0003724_increased_susceptibility_to1.21722056
75MP0005253_abnormal_eye_physiology1.21647327
76MP0006082_CNS_inflammation1.20686632
77MP0002429_abnormal_blood_cell1.15639062
78MP0005379_endocrine/exocrine_gland_phen1.15097167
79MP0003880_abnormal_central_pattern1.14668530
80MP0004142_abnormal_muscle_tone1.14436587
81MP0003787_abnormal_imprinting1.13106229
82MP0000631_abnormal_neuroendocrine_gland1.13104846
83MP0002009_preneoplasia1.12999413
84MP0002160_abnormal_reproductive_system1.12110337
85MP0002233_abnormal_nose_morphology1.09166118
86MP0002019_abnormal_tumor_incidence1.09075342
87MP0002163_abnormal_gland_morphology1.09061767
88MP0002006_tumorigenesis1.08689499
89MP0000313_abnormal_cell_death1.07877343
90MP0003567_abnormal_fetal_cardiomyocyte1.07218371
91MP0000858_altered_metastatic_potential1.07186986
92MP0003718_maternal_effect1.06814425
93MP0010307_abnormal_tumor_latency1.06692886
94MP0001853_heart_inflammation1.05460197
95MP0000350_abnormal_cell_proliferation1.04791204
96MP0001186_pigmentation_phenotype1.04319151
97MP0002751_abnormal_autonomic_nervous1.03861431
98MP0000778_abnormal_nervous_system1.02003460
99MP0008872_abnormal_physiological_respon1.01397777
100MP0003186_abnormal_redox_activity1.01251071
101MP0004742_abnormal_vestibular_system0.99796156
102MP0008995_early_reproductive_senescence0.99779589
103MP0006036_abnormal_mitochondrial_physio0.98176461
104MP0003937_abnormal_limbs/digits/tail_de0.97617339
105MP0001119_abnormal_female_reproductive0.97137334
106MP0001286_abnormal_eye_development0.96924956
107MP0005645_abnormal_hypothalamus_physiol0.96795542
108MP0002938_white_spotting0.96072614
109MP0005195_abnormal_posterior_eye0.96020418
110MP0000427_abnormal_hair_cycle0.95914091
111MP0001929_abnormal_gametogenesis0.95162456
112MP0000049_abnormal_middle_ear0.95087128
113MP0002184_abnormal_innervation0.94692637
114MP0002272_abnormal_nervous_system0.94037620
115MP0000372_irregular_coat_pigmentation0.93586714
116MP0001145_abnormal_male_reproductive0.93112874
117MP0002102_abnormal_ear_morphology0.93103109
118MP0001293_anophthalmia0.92594462
119MP0003123_paternal_imprinting0.92050457
120MP0005389_reproductive_system_phenotype0.89811797
121MP0008260_abnormal_autophagy0.89693503
122MP0004147_increased_porphyrin_level0.89591678
123MP0009745_abnormal_behavioral_response0.89456056
124MP0005409_darkened_coat_color0.89188355
125MP0001764_abnormal_homeostasis0.88005046
126MP0003448_altered_tumor_morphology0.87902819
127MP0003436_decreased_susceptibility_to0.87843749
128MP0001851_eye_inflammation0.87733586
129MP0003938_abnormal_ear_development0.86603283
130MP0003119_abnormal_digestive_system0.86375217
131MP0010155_abnormal_intestine_physiology0.86243102
132MP0004808_abnormal_hematopoietic_stem0.85668444
133MP0004885_abnormal_endolymph0.85621083
134MP0003878_abnormal_ear_physiology0.85167788
135MP0005377_hearing/vestibular/ear_phenot0.85167788
136MP0002166_altered_tumor_susceptibility0.85160523
137MP0000653_abnormal_sex_gland0.84202315
138MP0005391_vision/eye_phenotype0.83789199
139MP0001873_stomach_inflammation0.82517530
140MP0001324_abnormal_eye_pigmentation0.82507675
141MP0002752_abnormal_somatic_nervous0.81813415
142MP0002075_abnormal_coat/hair_pigmentati0.81515496
143MP0001919_abnormal_reproductive_system0.81372983
144MP0001845_abnormal_inflammatory_respons0.81319942
145MP0001905_abnormal_dopamine_level0.79666832
146MP0005451_abnormal_body_composition0.79506734
147MP0009379_abnormal_foot_pigmentation0.79471415
148MP0009697_abnormal_copulation0.79083567
149MP0003698_abnormal_male_reproductive0.78687142
150MP0005171_absent_coat_pigmentation0.78067299
151MP0010030_abnormal_orbit_morphology0.77539834
152MP0005310_abnormal_salivary_gland0.76992033
153MP0000383_abnormal_hair_follicle0.75779281
154MP0005397_hematopoietic_system_phenotyp0.75442285
155MP0001545_abnormal_hematopoietic_system0.75442285
156MP0002928_abnormal_bile_duct0.74009471
157MP0000613_abnormal_salivary_gland0.73983585
158MP0003861_abnormal_nervous_system0.69058989
159MP0001697_abnormal_embryo_size0.67562280
160MP0003755_abnormal_palate_morphology0.66360868

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.03571864
2Chromsome breakage (HP:0040012)4.82373484
3Acute necrotizing encephalopathy (HP:0006965)3.93514568
4Acute encephalopathy (HP:0006846)3.74085442
5Abnormality of the labia minora (HP:0012880)3.58333055
6Reticulocytopenia (HP:0001896)3.52887606
7Duplicated collecting system (HP:0000081)3.49649805
8Abnormal mitochondria in muscle tissue (HP:0008316)3.41950887
9Molar tooth sign on MRI (HP:0002419)3.25109226
10Abnormality of midbrain morphology (HP:0002418)3.25109226
11Colon cancer (HP:0003003)3.23266269
12Abnormality of the renal collecting system (HP:0004742)3.23078167
13Progressive macrocephaly (HP:0004481)3.20646515
14Increased hepatocellular lipid droplets (HP:0006565)3.18594295
15Abnormality of the preputium (HP:0100587)3.11154537
16Mitochondrial inheritance (HP:0001427)3.10885130
17Birth length less than 3rd percentile (HP:0003561)3.10608147
18Abnormality of chromosome stability (HP:0003220)3.10121501
19Lipid accumulation in hepatocytes (HP:0006561)2.98878304
20Meckel diverticulum (HP:0002245)2.98316983
21Increased CSF lactate (HP:0002490)2.93224263
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.89321800
23Abnormality of the ileum (HP:0001549)2.82284303
24Medial flaring of the eyebrow (HP:0010747)2.74182382
25Hyperglycinemia (HP:0002154)2.73262175
26True hermaphroditism (HP:0010459)2.72775050
27Abnormality of DNA repair (HP:0003254)2.71332915
28Abnormal ciliary motility (HP:0012262)2.67803802
2911 pairs of ribs (HP:0000878)2.66512387
30Pancreatic fibrosis (HP:0100732)2.62925579
31Oligodactyly (hands) (HP:0001180)2.62290486
32Volvulus (HP:0002580)2.60650143
33Pancreatic cysts (HP:0001737)2.59737796
34Type 2 muscle fiber atrophy (HP:0003554)2.58879569
35Clubbing of toes (HP:0100760)2.56370084
36Septo-optic dysplasia (HP:0100842)2.54817242
37Cerebral edema (HP:0002181)2.48454221
38Abnormal respiratory motile cilium morphology (HP:0005938)2.47728014
39Abnormal respiratory epithelium morphology (HP:0012253)2.47728014
40Ectopic kidney (HP:0000086)2.46042419
41Agnosia (HP:0010524)2.43590971
42Renal Fanconi syndrome (HP:0001994)2.43121467
43Nephronophthisis (HP:0000090)2.42512600
44Muscle fiber atrophy (HP:0100295)2.41760936
45Congenital primary aphakia (HP:0007707)2.40633369
46Pendular nystagmus (HP:0012043)2.37116228
47Gait imbalance (HP:0002141)2.36871439
48Type I transferrin isoform profile (HP:0003642)2.33060951
49Abnormal respiratory motile cilium physiology (HP:0012261)2.30451354
50T lymphocytopenia (HP:0005403)2.29694980
51Breast hypoplasia (HP:0003187)2.27432162
52Bone marrow hypocellularity (HP:0005528)2.27161538
53Abnormality of T cell number (HP:0011839)2.25912481
54Myelodysplasia (HP:0002863)2.21904730
55Nephrogenic diabetes insipidus (HP:0009806)2.21160852
56Absent thumb (HP:0009777)2.17126543
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.15363013
58Absent/shortened dynein arms (HP:0200106)2.15363013
59Hepatocellular necrosis (HP:0001404)2.15320280
60Microvesicular hepatic steatosis (HP:0001414)2.15234558
61Cleft eyelid (HP:0000625)2.14702551
62Duodenal stenosis (HP:0100867)2.13854470
63Small intestinal stenosis (HP:0012848)2.13854470
64Genital tract atresia (HP:0001827)2.12761036
653-Methylglutaconic aciduria (HP:0003535)2.12225528
66Amaurosis fugax (HP:0100576)2.11235400
67Sclerocornea (HP:0000647)2.10606712
68Vaginal atresia (HP:0000148)2.08485906
69IgG deficiency (HP:0004315)2.06765027
70Prostate neoplasm (HP:0100787)2.06697997
71Abnormality of cells of the erythroid lineage (HP:0012130)2.06387987
72Respiratory difficulties (HP:0002880)2.04673197
73Lymphoma (HP:0002665)2.04542760
74Premature graying of hair (HP:0002216)2.04256250
75IgM deficiency (HP:0002850)2.04212945
76Supernumerary spleens (HP:0009799)2.03955121
77Methylmalonic acidemia (HP:0002912)2.03830545
78Absent radius (HP:0003974)2.03328683
79Congenital stationary night blindness (HP:0007642)2.03301230
80Macrocytic anemia (HP:0001972)2.02753304
81Parakeratosis (HP:0001036)2.02479636
82Patellar aplasia (HP:0006443)2.02466460
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.02409504
84Recurrent abscess formation (HP:0002722)2.02109252
85Chronic hepatic failure (HP:0100626)2.01844521
86Abnormal number of erythroid precursors (HP:0012131)2.01167939
87Triphalangeal thumb (HP:0001199)2.00093536
88Renal cortical cysts (HP:0000803)2.00013064
89Poor coordination (HP:0002370)1.99302671
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99280341
91Severe combined immunodeficiency (HP:0004430)1.98760135
92Granulocytopenia (HP:0001913)1.98689552
93Horseshoe kidney (HP:0000085)1.98603780
94Optic disc pallor (HP:0000543)1.97293652
95Abnormal lung lobation (HP:0002101)1.96333983
96Abolished electroretinogram (ERG) (HP:0000550)1.96295473
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95055280
98Abnormal spermatogenesis (HP:0008669)1.94991233
99Oligodactyly (HP:0012165)1.94867634
100Leukodystrophy (HP:0002415)1.94232071
101Acute lymphatic leukemia (HP:0006721)1.93282607
102Abnormality of the renal medulla (HP:0100957)1.92341715
103Panhypogammaglobulinemia (HP:0003139)1.92273636
104Absent septum pellucidum (HP:0001331)1.91893165
105Abnormality of T cells (HP:0002843)1.90640198
106Abnormal sex determination (HP:0012244)1.90577211
107Sex reversal (HP:0012245)1.90577211
108Increased serum lactate (HP:0002151)1.90263838
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90227620
110Abnormality of alanine metabolism (HP:0010916)1.90227620
111Hyperalaninemia (HP:0003348)1.90227620
112Pallor (HP:0000980)1.90117814
113Abnormality of the carotid arteries (HP:0005344)1.89264634
114Cheilitis (HP:0100825)1.89148362
115Aplastic anemia (HP:0001915)1.88621654
116Abnormality of the pons (HP:0007361)1.88263388
117Preaxial hand polydactyly (HP:0001177)1.87835809
118Hepatic necrosis (HP:0002605)1.87226654
119Thyroiditis (HP:0100646)1.86848594
120Bronchiectasis (HP:0002110)1.86502397
121Abnormality of the duodenum (HP:0002246)1.83911734
122Absent forearm bone (HP:0003953)1.83003876
123Aplasia involving forearm bones (HP:0009822)1.83003876
124Sloping forehead (HP:0000340)1.82642479
125Aplasia/Hypoplasia of the patella (HP:0006498)1.82559377
126Abnormality of serum amino acid levels (HP:0003112)1.82024264
127Recurrent pneumonia (HP:0006532)1.81947820
128Increased intramyocellular lipid droplets (HP:0012240)1.80891637
129Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80396367
130Recurrent fungal infections (HP:0002841)1.79074608
131Recurrent viral infections (HP:0004429)1.78905428
132Rhinitis (HP:0012384)1.78843130
133Optic nerve hypoplasia (HP:0000609)1.78819805
134Hypoplasia of the pons (HP:0012110)1.77849501
135Abnormality of glycine metabolism (HP:0010895)1.77738613
136Abnormality of serine family amino acid metabolism (HP:0010894)1.77738613
137Impulsivity (HP:0100710)1.77178475
138Abnormality of eosinophils (HP:0001879)1.77170608
139Median cleft lip (HP:0000161)1.77168408
140Esophageal atresia (HP:0002032)1.76726023
141Eosinophilia (HP:0001880)1.76604220
142Recurrent cutaneous fungal infections (HP:0011370)1.76275741
143Chronic mucocutaneous candidiasis (HP:0002728)1.76275741
144Increased IgM level (HP:0003496)1.76129174
145Optic neuritis (HP:0100653)1.76031401
146Retrobulbar optic neuritis (HP:0100654)1.76031401
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.75895521
148Recurrent sinusitis (HP:0011108)1.75748106
149Lactic acidosis (HP:0003128)1.75276593
150Chronic sinusitis (HP:0011109)1.74654786
151Oligohydramnios (HP:0001562)1.74602848
152Medulloblastoma (HP:0002885)1.73977387
153Astigmatism (HP:0000483)1.73865106
154Leukopenia (HP:0001882)1.73594589
155Abnormality of the septum pellucidum (HP:0007375)1.73151777
156Methylmalonic aciduria (HP:0012120)1.72754113
157Hyperglycinuria (HP:0003108)1.72545886
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.72479887
159Congenital, generalized hypertrichosis (HP:0004540)1.71881773
160Postaxial foot polydactyly (HP:0001830)1.70035265
161Carpal bone hypoplasia (HP:0001498)1.68769854
162Abnormality of the prostate (HP:0008775)1.68223283
163Anencephaly (HP:0002323)1.67906867
164Obstructive lung disease (HP:0006536)1.67791255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK32.67179079
2SRPK12.61903517
3IRAK42.56168232
4VRK22.54488537
5PLK42.50803094
6ZAK2.33747789
7EIF2AK32.31463414
8WEE12.20974858
9TXK2.19898637
10WNK32.15339875
11NME12.10426742
12MKNK22.01019215
13TLK12.00473749
14EEF2K1.98062080
15CASK1.94492088
16CDC71.92130353
17MAP3K141.84891489
18STK161.84850544
19MAPKAPK31.83601983
20VRK11.83341787
21EIF2AK11.75694636
22MAP4K21.70948318
23BUB11.70239935
24FRK1.68299929
25BRD41.68251434
26MKNK11.63212629
27NME21.61432756
28TRPM71.52973297
29NEK11.51359808
30EIF2AK21.51064000
31ACVR1B1.50765833
32MAP4K11.47383450
33ATR1.46745020
34RPS6KB21.44790010
35MST41.41498595
36TAF11.41405632
37YES11.38994371
38TTK1.35849465
39CDK71.32151340
40PLK11.30817119
41DYRK31.30172359
42TNIK1.28121846
43IKBKB1.26329492
44TRIM281.24171280
45EPHA21.24145116
46STK41.24089598
47MAP3K31.21083618
48CDK121.20543592
49NEK21.19880695
50BRSK21.19586186
51CLK11.19298724
52CHEK21.18445443
53NLK1.15807642
54PINK11.15040358
55BMPR1B1.13509915
56KIT1.12048171
57AURKB1.09197638
58MAP3K41.08514413
59PBK1.07137960
60JAK31.06296151
61TEC1.05504303
62IRAK11.05132282
63CDK81.04911990
64NUAK11.04905100
65TYK21.04635357
66PNCK1.03289838
67CDK31.02886854
68MAPK151.01594921
69IKBKE1.00140251
70PLK20.96192283
71PASK0.96141089
72WNK40.93458840
73PIM10.92715219
74BTK0.91189691
75CDK40.91185426
76STK38L0.91052118
77IRAK20.90633458
78CSNK1G20.89832320
79NEK90.89028102
80TSSK60.88767932
81PLK30.87232030
82CHEK10.86606021
83OXSR10.84240628
84MAPKAPK50.83977177
85CSNK1G10.82408686
86ADRBK20.81858332
87ATM0.81686497
88ALK0.80732008
89STK390.80571217
90CSNK1G30.77713373
91PAK30.76547082
92TAOK30.76448862
93BCKDK0.75222219
94MAPK130.73968023
95DMPK0.71404159
96BLK0.70690041
97PRKCG0.70103876
98CHUK0.69814636
99RPS6KA50.64408776
100CSNK1E0.62450120
101BCR0.62161291
102LCK0.61673306
103GRK10.60781921
104NEK60.60357006
105LYN0.59397473
106AURKA0.58935507
107BRSK10.57806025
108SGK20.55637762
109CSK0.55571155
110CDK90.55137524
111ITK0.54808227
112SYK0.54076676
113PDK20.53899315
114CSNK2A10.53470256
115CSNK1A1L0.53068660
116STK100.52970112
117CDK190.52219621
118CCNB10.52048695
119INSRR0.51713235
120MARK30.51321997
121CSNK2A20.49840776
122PIM20.48818592
123RPS6KA40.48108304
124STK30.47657235
125CDK20.46797616
126MATK0.45298868
127MAP2K70.44469494
128MUSK0.44204923
129PRKDC0.41938240
130PRKCI0.41156355
131MAP2K30.40581522
132ADRBK10.40358040
133MINK10.40278157
134AKT30.39800913
135NTRK20.39653112
136CDK10.38961177
137EPHA40.38598378
138PKN10.38341917
139TBK10.38083844
140DYRK20.37843754
141CSNK1A10.35916673
142TIE10.35099222
143PRKCQ0.32563515
144STK110.32154898
145BRAF0.32142110

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.71394430
2Mismatch repair_Homo sapiens_hsa034303.63500924
3RNA polymerase_Homo sapiens_hsa030203.37249355
4Homologous recombination_Homo sapiens_hsa034403.16410159
5Oxidative phosphorylation_Homo sapiens_hsa001903.14630514
6Ribosome_Homo sapiens_hsa030102.95481780
7Fanconi anemia pathway_Homo sapiens_hsa034602.82318321
8Parkinsons disease_Homo sapiens_hsa050122.80252438
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78809560
10Spliceosome_Homo sapiens_hsa030402.58373648
11Non-homologous end-joining_Homo sapiens_hsa034502.56569229
12Nucleotide excision repair_Homo sapiens_hsa034202.44997045
13Base excision repair_Homo sapiens_hsa034102.30391820
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.26873395
15Basal transcription factors_Homo sapiens_hsa030222.25999098
16Pyrimidine metabolism_Homo sapiens_hsa002402.19736112
17Proteasome_Homo sapiens_hsa030502.19617782
18Primary immunodeficiency_Homo sapiens_hsa053402.09145932
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.91997500
20One carbon pool by folate_Homo sapiens_hsa006701.85004543
21Cell cycle_Homo sapiens_hsa041101.83581548
22RNA transport_Homo sapiens_hsa030131.80098892
23Alzheimers disease_Homo sapiens_hsa050101.67223983
24RNA degradation_Homo sapiens_hsa030181.66037767
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.59233577
26Protein export_Homo sapiens_hsa030601.54036904
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.53994675
28p53 signaling pathway_Homo sapiens_hsa041151.52194718
29Allograft rejection_Homo sapiens_hsa053301.47534613
30Graft-versus-host disease_Homo sapiens_hsa053321.46585318
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43130295
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42870120
33Cardiac muscle contraction_Homo sapiens_hsa042601.40625104
34Herpes simplex infection_Homo sapiens_hsa051681.37954358
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37339561
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.36564102
37Purine metabolism_Homo sapiens_hsa002301.29429498
38Measles_Homo sapiens_hsa051621.27532308
39Autoimmune thyroid disease_Homo sapiens_hsa053201.23465982
40mRNA surveillance pathway_Homo sapiens_hsa030151.20508830
41Propanoate metabolism_Homo sapiens_hsa006401.15865431
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12748665
43Epstein-Barr virus infection_Homo sapiens_hsa051691.12665920
44Hematopoietic cell lineage_Homo sapiens_hsa046401.10734757
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.10645814
46Antigen processing and presentation_Homo sapiens_hsa046121.10623580
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07461943
48Steroid biosynthesis_Homo sapiens_hsa001001.03218809
49Systemic lupus erythematosus_Homo sapiens_hsa053221.00258261
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98776406
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94039203
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93231783
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90898464
54Nicotine addiction_Homo sapiens_hsa050330.89194085
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87441560
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86942698
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86704768
58Butanoate metabolism_Homo sapiens_hsa006500.82608486
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81864017
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77992839
61Asthma_Homo sapiens_hsa053100.76889240
62Arachidonic acid metabolism_Homo sapiens_hsa005900.76882253
63Other glycan degradation_Homo sapiens_hsa005110.76444105
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76157448
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75905356
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71960030
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69593825
68Basal cell carcinoma_Homo sapiens_hsa052170.67472403
69Sphingolipid metabolism_Homo sapiens_hsa006000.67146449
70Vitamin B6 metabolism_Homo sapiens_hsa007500.66345168
71Nitrogen metabolism_Homo sapiens_hsa009100.66035591
72Folate biosynthesis_Homo sapiens_hsa007900.65977645
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.65551859
74Olfactory transduction_Homo sapiens_hsa047400.63612316
75Viral carcinogenesis_Homo sapiens_hsa052030.62151760
76Leishmaniasis_Homo sapiens_hsa051400.61857294
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61632385
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.61398856
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60939514
80Influenza A_Homo sapiens_hsa051640.60416531
81T cell receptor signaling pathway_Homo sapiens_hsa046600.59408923
82Pyruvate metabolism_Homo sapiens_hsa006200.59167900
83HTLV-I infection_Homo sapiens_hsa051660.59019131
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58361543
85Oocyte meiosis_Homo sapiens_hsa041140.57417460
86Apoptosis_Homo sapiens_hsa042100.56683810
87Linoleic acid metabolism_Homo sapiens_hsa005910.55870658
88Type I diabetes mellitus_Homo sapiens_hsa049400.55770417
89Caffeine metabolism_Homo sapiens_hsa002320.53444745
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53072150
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.52995937
92Selenocompound metabolism_Homo sapiens_hsa004500.51408190
93Malaria_Homo sapiens_hsa051440.51228006
94Legionellosis_Homo sapiens_hsa051340.51018890
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50450304
96Phototransduction_Homo sapiens_hsa047440.49963238
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49743225
98Regulation of autophagy_Homo sapiens_hsa041400.49737151
99Fatty acid elongation_Homo sapiens_hsa000620.49495186
100Peroxisome_Homo sapiens_hsa041460.48934313
101Hedgehog signaling pathway_Homo sapiens_hsa043400.48645413
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48539607
103B cell receptor signaling pathway_Homo sapiens_hsa046620.46431418
104Tryptophan metabolism_Homo sapiens_hsa003800.45030198
105Ether lipid metabolism_Homo sapiens_hsa005650.43458194
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.43184823
107Taste transduction_Homo sapiens_hsa047420.42931363
108Hepatitis B_Homo sapiens_hsa051610.41899504
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41472061
110Morphine addiction_Homo sapiens_hsa050320.39679161
111Small cell lung cancer_Homo sapiens_hsa052220.38749918
112Huntingtons disease_Homo sapiens_hsa050160.37804851
113Wnt signaling pathway_Homo sapiens_hsa043100.37726862
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37184977
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35910529
116Sulfur relay system_Homo sapiens_hsa041220.35242559
117Viral myocarditis_Homo sapiens_hsa054160.33708291
118Notch signaling pathway_Homo sapiens_hsa043300.33668317
119Chemical carcinogenesis_Homo sapiens_hsa052040.30399519
120Osteoclast differentiation_Homo sapiens_hsa043800.29977319
121Collecting duct acid secretion_Homo sapiens_hsa049660.29907896
122Fatty acid metabolism_Homo sapiens_hsa012120.29038657
123Pertussis_Homo sapiens_hsa051330.28979372
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27779734
125Pentose phosphate pathway_Homo sapiens_hsa000300.27557865
126Vitamin digestion and absorption_Homo sapiens_hsa049770.26557286
127MicroRNAs in cancer_Homo sapiens_hsa052060.26310303
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25538377
129Hippo signaling pathway_Homo sapiens_hsa043900.25338688
130TNF signaling pathway_Homo sapiens_hsa046680.24207035
131Rheumatoid arthritis_Homo sapiens_hsa053230.24160921
132Metabolic pathways_Homo sapiens_hsa011000.21305060
133Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21255918
134Glutathione metabolism_Homo sapiens_hsa004800.21187378
135Hepatitis C_Homo sapiens_hsa051600.21157143
136Prostate cancer_Homo sapiens_hsa052150.20939295
137Acute myeloid leukemia_Homo sapiens_hsa052210.20054266
138Tuberculosis_Homo sapiens_hsa051520.19660189
139Toxoplasmosis_Homo sapiens_hsa051450.19066037
140Steroid hormone biosynthesis_Homo sapiens_hsa001400.18702512
141Pathways in cancer_Homo sapiens_hsa052000.18501767
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17879293
143N-Glycan biosynthesis_Homo sapiens_hsa005100.16805936
144Retinol metabolism_Homo sapiens_hsa008300.16581766
145Serotonergic synapse_Homo sapiens_hsa047260.15516410
146Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.14114009
147beta-Alanine metabolism_Homo sapiens_hsa004100.11911093
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.11703688
149Fatty acid degradation_Homo sapiens_hsa000710.10564046
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09716507
151Alcoholism_Homo sapiens_hsa050340.09064511
152Lysine degradation_Homo sapiens_hsa003100.06426833
153Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.06297833

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