TTF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.61081203
2protein localization to kinetochore (GO:0034501)5.18258022
3nuclear pore organization (GO:0006999)4.97469158
4DNA strand elongation involved in DNA replication (GO:0006271)4.79500346
5DNA replication initiation (GO:0006270)4.76514078
6nuclear pore complex assembly (GO:0051292)4.70913525
7DNA strand elongation (GO:0022616)4.55418049
8DNA replication-dependent nucleosome assembly (GO:0006335)4.43102147
9DNA replication-dependent nucleosome organization (GO:0034723)4.43102147
10telomere maintenance via semi-conservative replication (GO:0032201)4.41698922
11protein localization to chromosome, centromeric region (GO:0071459)4.36301766
12mitotic nuclear envelope disassembly (GO:0007077)4.32889686
13folic acid-containing compound biosynthetic process (GO:0009396)4.27215274
14mitotic chromosome condensation (GO:0007076)4.19943277
15mitotic metaphase plate congression (GO:0007080)4.10809783
16mitotic recombination (GO:0006312)4.06874409
17mitotic sister chromatid segregation (GO:0000070)4.05227251
18telomere maintenance via recombination (GO:0000722)4.03173598
19membrane disassembly (GO:0030397)4.01471440
20nuclear envelope disassembly (GO:0051081)4.01471440
21sister chromatid segregation (GO:0000819)4.00776356
22IMP biosynthetic process (GO:0006188)3.97794639
23attachment of spindle microtubules to kinetochore (GO:0008608)3.95202394
24DNA replication checkpoint (GO:0000076)3.94158722
25kinetochore organization (GO:0051383)3.93878548
26DNA geometric change (GO:0032392)3.89284874
27DNA duplex unwinding (GO:0032508)3.88225362
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.82527833
29chromatin remodeling at centromere (GO:0031055)3.82522369
30CENP-A containing nucleosome assembly (GO:0034080)3.79525649
31regulation of DNA endoreduplication (GO:0032875)3.75342767
32replication fork processing (GO:0031297)3.74635029
33metaphase plate congression (GO:0051310)3.72390815
34formation of translation preinitiation complex (GO:0001731)3.64326196
35pore complex assembly (GO:0046931)3.63091443
36nucleobase biosynthetic process (GO:0046112)3.62982581
37regulation of histone H3-K9 methylation (GO:0051570)3.60211349
38regulation of spindle organization (GO:0090224)3.60021228
39DNA replication-independent nucleosome assembly (GO:0006336)3.57101980
40DNA replication-independent nucleosome organization (GO:0034724)3.57101980
41double-strand break repair via nonhomologous end joining (GO:0006303)3.54595954
42non-recombinational repair (GO:0000726)3.54595954
43maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.53553133
44telomere maintenance via telomere lengthening (GO:0010833)3.50659293
45IMP metabolic process (GO:0046040)3.50635019
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.49266859
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46425682
48meiotic chromosome segregation (GO:0045132)3.45653097
49establishment of integrated proviral latency (GO:0075713)3.44888747
50ribosomal small subunit assembly (GO:0000028)3.43843059
51somatic diversification of immune receptors via somatic mutation (GO:0002566)3.42136098
52somatic hypermutation of immunoglobulin genes (GO:0016446)3.42136098
53mitotic sister chromatid cohesion (GO:0007064)3.39453588
54establishment of chromosome localization (GO:0051303)3.39385565
55regulation of gene silencing by RNA (GO:0060966)3.38856368
56regulation of posttranscriptional gene silencing (GO:0060147)3.38856368
57regulation of gene silencing by miRNA (GO:0060964)3.38856368
58regulation of centrosome duplication (GO:0010824)3.37095217
59maturation of SSU-rRNA (GO:0030490)3.36565244
60negative regulation of DNA-dependent DNA replication (GO:2000104)3.35094748
61negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.33843430
62heterochromatin organization (GO:0070828)3.33812779
63translesion synthesis (GO:0019985)3.32449740
64kinetochore assembly (GO:0051382)3.32402395
65DNA synthesis involved in DNA repair (GO:0000731)3.32236972
66chromatin assembly or disassembly (GO:0006333)3.31630959
67regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31211357
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31012799
69positive regulation of chromosome segregation (GO:0051984)3.26412864
70mitotic spindle checkpoint (GO:0071174)3.25467673
71DNA conformation change (GO:0071103)3.24422017
72regulation of sister chromatid segregation (GO:0033045)3.23931626
73regulation of mitotic sister chromatid separation (GO:0010965)3.23931626
74regulation of mitotic sister chromatid segregation (GO:0033047)3.23931626
75regulation of mitotic spindle organization (GO:0060236)3.23002606
76negative regulation of histone methylation (GO:0031061)3.21959386
77histone exchange (GO:0043486)3.20842115
78purine nucleobase biosynthetic process (GO:0009113)3.16884106
79mitotic spindle assembly checkpoint (GO:0007094)3.16728620
80protein localization to chromosome (GO:0034502)3.15941261
81DNA ligation (GO:0006266)3.14118972
82DNA strand renaturation (GO:0000733)3.12924572
83protein K6-linked ubiquitination (GO:0085020)3.12381946
84sister chromatid cohesion (GO:0007062)3.10809835
85chromatin assembly (GO:0031497)3.10032913
86regulation of centrosome cycle (GO:0046605)3.07663268
87positive regulation of histone H3-K4 methylation (GO:0051571)3.06835314
88mismatch repair (GO:0006298)3.06117757
89regulation of sister chromatid cohesion (GO:0007063)3.05789968
90double-strand break repair via homologous recombination (GO:0000724)3.04541208
91recombinational repair (GO:0000725)3.04379180
92regulation of helicase activity (GO:0051095)3.03847805
93synapsis (GO:0007129)3.03475251
94pre-miRNA processing (GO:0031054)3.03464039
95telomere maintenance (GO:0000723)3.03123026
96DNA double-strand break processing (GO:0000729)3.03117267
97DNA replication (GO:0006260)3.03097139
98regulation of chromosome segregation (GO:0051983)3.02928978
99nuclear envelope organization (GO:0006998)3.02909303
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.02131085
101telomere organization (GO:0032200)3.02131076
102DNA topological change (GO:0006265)3.01950788
103postreplication repair (GO:0006301)3.01845869
104regulation of centriole replication (GO:0046599)2.98956848
105regulation of translational fidelity (GO:0006450)2.98876748
106viral transcription (GO:0019083)2.97501087
107translational termination (GO:0006415)2.96269260
108chromosome condensation (GO:0030261)2.96084427
109spindle checkpoint (GO:0031577)2.95759305
110negative regulation of chromosome segregation (GO:0051985)2.95758871
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.94639103
112positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94639103
113positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94639103
114regulation of nuclear cell cycle DNA replication (GO:0033262)2.92778144
115chromosome segregation (GO:0007059)2.92444546
116spindle assembly checkpoint (GO:0071173)2.89374893
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89346451
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.88911399
119negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88911399
120negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88911399
121negative regulation of sister chromatid segregation (GO:0033046)2.88911399
122ATP-dependent chromatin remodeling (GO:0043044)2.86613842
123negative regulation of RNA splicing (GO:0033119)2.85845997
124dosage compensation (GO:0007549)2.85822226
125ribosome assembly (GO:0042255)2.83925210

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.13080806
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11243513
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.79968924
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.38985211
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.25119093
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.80810540
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.69657958
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55720540
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31559717
10AR_21909140_ChIP-Seq_LNCAP_Human2.28667485
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.26403549
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17573583
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.17143283
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11127748
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01134865
16MYC_22102868_ChIP-Seq_BL_Human2.01129249
17* XRN2_22483619_ChIP-Seq_HELA_Human2.00867055
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00644887
19E2F7_22180533_ChIP-Seq_HELA_Human10.5242660
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93997836
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.93053294
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88014272
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.86823551
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82573246
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.72498083
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71792621
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71163737
28VDR_23849224_ChIP-Seq_CD4+_Human1.70680298
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68979303
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.67993436
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65638231
32FOXP3_21729870_ChIP-Seq_TREG_Human1.63651738
33CIITA_25753668_ChIP-Seq_RAJI_Human1.59425086
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59195903
35DCP1A_22483619_ChIP-Seq_HELA_Human1.56042608
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55777003
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.55175626
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54994909
39TTF2_22483619_ChIP-Seq_HELA_Human1.54990601
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49635768
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46274308
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.44993894
43ELK1_19687146_ChIP-ChIP_HELA_Human1.43716596
44* MYC_18940864_ChIP-ChIP_HL60_Human1.42778544
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40618593
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40386753
47ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.38214793
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37647487
49* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36954466
50GABP_19822575_ChIP-Seq_HepG2_Human1.35192766
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35101449
52VDR_21846776_ChIP-Seq_THP-1_Human1.31079524
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.29826148
54KDM5A_27292631_Chip-Seq_BREAST_Human1.28654667
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27225757
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26857503
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.25559829
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.24126878
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23964608
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23692678
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.22637062
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22601556
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20485091
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19045034
65TFEB_21752829_ChIP-Seq_HELA_Human1.17215417
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15362792
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15027757
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14632616
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11854220
70NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11585708
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10768401
72* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08676179
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07122556
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07122556
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07122556
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04773312
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03618852
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03059446
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01900374
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01803089
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01523641
82YY1_21170310_ChIP-Seq_MESCs_Mouse0.99402722
83ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98913161
84SALL1_21062744_ChIP-ChIP_HESCs_Human0.98859221
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98651609
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.98187274
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97388652
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.96286809
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95132221
90EWS_26573619_Chip-Seq_HEK293_Human0.94002556
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91926516
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89627591
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89326278
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88099237
95SPI1_23547873_ChIP-Seq_NB4_Human0.87769713
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87446275
97RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86702945
98IRF1_19129219_ChIP-ChIP_H3396_Human0.86214120
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85713649
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85039338
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83346525
102* SOX2_16153702_ChIP-ChIP_HESCs_Human0.81663434
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81524384
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.80955865
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80314382
106* NANOG_16153702_ChIP-ChIP_HESCs_Human0.79981969
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78690053
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78413967
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78196749
110HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78139815
111CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78060258
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77684034
113CHD1_26751641_Chip-Seq_LNCaP_Human0.77521420
114FUS_26573619_Chip-Seq_HEK293_Human0.75700719
115CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.69894210
116PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69125773
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.65500312
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.63416815
119POU5F1_16153702_ChIP-ChIP_HESCs_Human0.61262755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62909754
2MP0010094_abnormal_chromosome_stability4.51744352
3MP0003111_abnormal_nucleus_morphology4.25339093
4MP0004957_abnormal_blastocyst_morpholog3.82917856
5MP0003077_abnormal_cell_cycle3.74135249
6MP0008057_abnormal_DNA_replication3.57363932
7MP0008058_abnormal_DNA_repair2.86132226
8MP0010352_gastrointestinal_tract_polyps2.59765799
9MP0010307_abnormal_tumor_latency2.47894982
10MP0008007_abnormal_cellular_replicative2.43057238
11MP0009697_abnormal_copulation2.34333018
12MP0002396_abnormal_hematopoietic_system2.31745164
13MP0008932_abnormal_embryonic_tissue2.31625566
14MP0001730_embryonic_growth_arrest2.25730430
15MP0000350_abnormal_cell_proliferation2.22233243
16MP0006292_abnormal_olfactory_placode1.90872069
17MP0003123_paternal_imprinting1.86397142
18MP0005076_abnormal_cell_differentiation1.82787280
19MP0005380_embryogenesis_phenotype1.79968213
20MP0001672_abnormal_embryogenesis/_devel1.79968213
21MP0001697_abnormal_embryo_size1.69264934
22MP0000490_abnormal_crypts_of1.68295807
23MP0004808_abnormal_hematopoietic_stem1.66549124
24MP0004197_abnormal_fetal_growth/weight/1.65752875
25MP0003984_embryonic_growth_retardation1.65749424
26MP0008877_abnormal_DNA_methylation1.63340062
27MP0002009_preneoplasia1.62963544
28MP0002088_abnormal_embryonic_growth/wei1.62833370
29MP0002085_abnormal_embryonic_tissue1.60289233
30MP0002084_abnormal_developmental_patter1.56506168
31MP0003705_abnormal_hypodermis_morpholog1.56208340
32MP0002086_abnormal_extraembryonic_tissu1.55612947
33MP0002080_prenatal_lethality1.55493835
34MP0000372_irregular_coat_pigmentation1.43595735
35MP0002019_abnormal_tumor_incidence1.43051116
36MP0000313_abnormal_cell_death1.42336901
37MP0001293_anophthalmia1.39837124
38MP0003786_premature_aging1.39258692
39MP0009278_abnormal_bone_marrow1.36922339
40MP0003566_abnormal_cell_adhesion1.32865638
41MP0005397_hematopoietic_system_phenotyp1.32204697
42MP0001545_abnormal_hematopoietic_system1.32204697
43MP0003121_genomic_imprinting1.29946143
44MP0003567_abnormal_fetal_cardiomyocyte1.26981429
45MP0000703_abnormal_thymus_morphology1.21518980
46MP0006054_spinal_hemorrhage1.20089959
47MP0003890_abnormal_embryonic-extraembry1.18970750
48MP0002398_abnormal_bone_marrow1.18044259
49MP0006035_abnormal_mitochondrial_morpho1.17051564
50MP0003941_abnormal_skin_development1.13812495
51MP0002722_abnormal_immune_system1.12058129
52MP0010030_abnormal_orbit_morphology1.11496077
53MP0005023_abnormal_wound_healing1.09890866
54MP0009333_abnormal_splenocyte_physiolog1.09548159
55MP0003763_abnormal_thymus_physiology1.08601222
56MP0003806_abnormal_nucleotide_metabolis1.08582407
57MP0009053_abnormal_anal_canal1.08108296
58MP0001346_abnormal_lacrimal_gland1.07832328
59MP0002938_white_spotting1.07311854
60MP0000689_abnormal_spleen_morphology1.06903956
61MP0001915_intracranial_hemorrhage1.04933550
62MP0002160_abnormal_reproductive_system1.04821061
63MP0000858_altered_metastatic_potential1.04302961
64MP0002163_abnormal_gland_morphology1.03655008
65MP0009672_abnormal_birth_weight1.03357605
66MP0008995_early_reproductive_senescence1.02435416
67MP0001661_extended_life_span0.95328508
68MP0002429_abnormal_blood_cell0.90283105
69MP0002210_abnormal_sex_determination0.89646180
70MP0009703_decreased_birth_body0.89397318
71MP0000537_abnormal_urethra_morphology0.87827709
72MP0002111_abnormal_tail_morphology0.86132075
73MP0002092_abnormal_eye_morphology0.85498215
74MP0003943_abnormal_hepatobiliary_system0.83383065
75MP0000733_abnormal_muscle_development0.83041664
76MP0005174_abnormal_tail_pigmentation0.83011618
77MP0000569_abnormal_digit_pigmentation0.82790421
78MP0004233_abnormal_muscle_weight0.82741361
79MP0000371_diluted_coat_color0.82688216
80MP0001849_ear_inflammation0.82290404
81MP0005621_abnormal_cell_physiology0.81239294
82MP0005384_cellular_phenotype0.81096195
83MP0001145_abnormal_male_reproductive0.80680497
84MP0002877_abnormal_melanocyte_morpholog0.80041753
85MP0001800_abnormal_humoral_immune0.79313499
86MP0004185_abnormal_adipocyte_glucose0.78670512
87MP0001873_stomach_inflammation0.78428908
88MP0000716_abnormal_immune_system0.78406809
89MP0003119_abnormal_digestive_system0.76136313
90MP0002075_abnormal_coat/hair_pigmentati0.75319723
91MP0003699_abnormal_female_reproductive0.75178634
92MP0000358_abnormal_cell_content/0.74298100
93MP0002653_abnormal_ependyma_morphology0.73442859
94MP0002166_altered_tumor_susceptibility0.72681101
95MP0004133_heterotaxia0.72507543
96MP0005408_hypopigmentation0.71975016
97MP0001286_abnormal_eye_development0.71268427
98MP0003698_abnormal_male_reproductive0.70763601
99MP0002697_abnormal_eye_size0.70283242
100MP0003448_altered_tumor_morphology0.69941856
101MP0000428_abnormal_craniofacial_morphol0.69305521
102MP0000477_abnormal_intestine_morphology0.69073712
103MP0005389_reproductive_system_phenotype0.67005211
104MP0002452_abnormal_antigen_presenting0.66927578
105MP0006036_abnormal_mitochondrial_physio0.66775972
106MP0002925_abnormal_cardiovascular_devel0.66689683
107MP0000432_abnormal_head_morphology0.66605141
108MP0000685_abnormal_immune_system0.64916851
109MP0001835_abnormal_antigen_presentation0.64764254
110MP0002420_abnormal_adaptive_immunity0.64061525
111MP0003718_maternal_effect0.63773830
112MP0001119_abnormal_female_reproductive0.63770295
113MP0005647_abnormal_sex_gland0.62855744
114MP0001819_abnormal_immune_cell0.62808081
115MP0003937_abnormal_limbs/digits/tail_de0.62552067
116MP0001929_abnormal_gametogenesis0.61702270
117MP0000653_abnormal_sex_gland0.60518854
118MP0002405_respiratory_system_inflammati0.60501540
119MP0002161_abnormal_fertility/fecundity0.58844717
120MP0006072_abnormal_retinal_apoptosis0.57320324
121MP0000427_abnormal_hair_cycle0.57051886
122MP0003221_abnormal_cardiomyocyte_apopto0.56773444
123MP0005395_other_phenotype0.56525207
124MP0001881_abnormal_mammary_gland0.55337200
125MP0005501_abnormal_skin_physiology0.55091057
126MP0000383_abnormal_hair_follicle0.54634131
127MP0003186_abnormal_redox_activity0.54628705
128MP0003861_abnormal_nervous_system0.54412844
129MP0005075_abnormal_melanosome_morpholog0.54389855
130MP0001919_abnormal_reproductive_system0.54320073
131MP0003136_yellow_coat_color0.53951960
132MP0002006_tumorigenesis0.53462188
133MP0003315_abnormal_perineum_morphology0.52770163
134MP0000627_abnormal_mammary_gland0.52614737
135MP0002095_abnormal_skin_pigmentation0.52183215
136MP0003787_abnormal_imprinting0.51952879
137MP0005083_abnormal_biliary_tract0.51338872

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.21657545
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03381784
3Birth length less than 3rd percentile (HP:0003561)3.84036621
4Reticulocytopenia (HP:0001896)3.75670586
5Ependymoma (HP:0002888)3.75505400
6Selective tooth agenesis (HP:0001592)3.37360809
7Medulloblastoma (HP:0002885)3.28968930
8Abnormality of chromosome stability (HP:0003220)3.24842543
9Colon cancer (HP:0003003)3.21872173
10Abnormal number of incisors (HP:0011064)3.21036765
11Agnosia (HP:0010524)3.07564533
12Patellar aplasia (HP:0006443)2.90017511
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.82813542
14Meckel diverticulum (HP:0002245)2.82354944
15Ectopic kidney (HP:0000086)2.80244833
16Breast hypoplasia (HP:0003187)2.75075008
17Abnormality of the ileum (HP:0001549)2.72552649
18Abnormality of cells of the erythroid lineage (HP:0012130)2.72158341
19Abnormality of DNA repair (HP:0003254)2.70086357
20Degeneration of anterior horn cells (HP:0002398)2.69893051
21Abnormality of the anterior horn cell (HP:0006802)2.69893051
22Aplasia/Hypoplasia of the patella (HP:0006498)2.68790767
23Abnormality of the preputium (HP:0100587)2.68352391
24Rhabdomyosarcoma (HP:0002859)2.67330208
25Myelodysplasia (HP:0002863)2.65136994
26Impulsivity (HP:0100710)2.63792650
27Microvesicular hepatic steatosis (HP:0001414)2.62510629
28Abnormality of the labia minora (HP:0012880)2.57768117
29Increased nuchal translucency (HP:0010880)2.57148967
30Acute lymphatic leukemia (HP:0006721)2.56930600
31Absent thumb (HP:0009777)2.54195188
32Abnormality of the astrocytes (HP:0100707)2.51875610
33Astrocytoma (HP:0009592)2.51875610
34Short 4th metacarpal (HP:0010044)2.51085906
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51085906
36Abnormal number of erythroid precursors (HP:0012131)2.50925341
37Duodenal stenosis (HP:0100867)2.50880380
38Small intestinal stenosis (HP:0012848)2.50880380
39Absent radius (HP:0003974)2.49444912
40Oral leukoplakia (HP:0002745)2.47274960
41Deviation of the thumb (HP:0009603)2.38107528
42Proximal placement of thumb (HP:0009623)2.38058423
43Basal cell carcinoma (HP:0002671)2.30183680
44Neoplasm of the oral cavity (HP:0100649)2.29684575
45Aplasia involving forearm bones (HP:0009822)2.28537481
46Absent forearm bone (HP:0003953)2.28537481
4711 pairs of ribs (HP:0000878)2.27849595
48Glioma (HP:0009733)2.27651031
49High pitched voice (HP:0001620)2.23270867
50Neoplasm of the pancreas (HP:0002894)2.23151031
51Missing ribs (HP:0000921)2.21737311
52Abnormal lung lobation (HP:0002101)2.19385758
53Arteriovenous malformation (HP:0100026)2.19325991
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18692074
55Duplicated collecting system (HP:0000081)2.18134423
56Volvulus (HP:0002580)2.17556743
57Sloping forehead (HP:0000340)2.16226737
58Choanal atresia (HP:0000453)2.15668023
59Cafe-au-lait spot (HP:0000957)2.15627867
60Abnormality of the carotid arteries (HP:0005344)2.14670548
61Abnormality of the duodenum (HP:0002246)2.14246688
62Tracheoesophageal fistula (HP:0002575)2.10575805
63Progressive muscle weakness (HP:0003323)2.09884503
64Neoplasm of striated muscle (HP:0009728)2.09494024
65Bone marrow hypocellularity (HP:0005528)2.09352214
66Amaurosis fugax (HP:0100576)2.08090868
67Supernumerary spleens (HP:0009799)2.07501067
68Carpal bone hypoplasia (HP:0001498)2.07344366
69Abnormality of the pons (HP:0007361)2.07276118
70Hypoplasia of the pons (HP:0012110)2.06928733
71Overlapping toe (HP:0001845)2.05536538
72Progressive external ophthalmoplegia (HP:0000590)2.05393422
73Abnormality of homocysteine metabolism (HP:0010919)2.03637429
74Homocystinuria (HP:0002156)2.03637429
75Neoplasm of the adrenal cortex (HP:0100641)2.02611348
76Embryonal neoplasm (HP:0002898)2.01578366
77IgM deficiency (HP:0002850)2.01411439
78Gastrointestinal carcinoma (HP:0002672)1.99703537
79Malignant gastrointestinal tract tumors (HP:0006749)1.99703537
80Multiple enchondromatosis (HP:0005701)1.99478127
81Thrombocytosis (HP:0001894)1.99345119
82Atresia of the external auditory canal (HP:0000413)1.98266433
83Aplasia/Hypoplasia of the sternum (HP:0006714)1.97125486
84Abnormality of cochlea (HP:0000375)1.96647090
85Cellular immunodeficiency (HP:0005374)1.96525334
86Prominent nose (HP:0000448)1.95371338
87Acute myeloid leukemia (HP:0004808)1.94866309
88Biliary tract neoplasm (HP:0100574)1.94566716
89Premature graying of hair (HP:0002216)1.94478767
90Pallor (HP:0000980)1.93704502
91Short thumb (HP:0009778)1.92615696
92Abnormality of the renal collecting system (HP:0004742)1.92163300
93Ankle contracture (HP:0006466)1.92153867
94Poikiloderma (HP:0001029)1.90728061
95Lymphoma (HP:0002665)1.89861962
96Facial cleft (HP:0002006)1.89475501
97Abnormality of the calcaneus (HP:0008364)1.87732797
98Neoplasm of the colon (HP:0100273)1.86741811
99Facial hemangioma (HP:0000329)1.86085484
100Aplasia/hypoplasia of the humerus (HP:0006507)1.85723561
101Pancytopenia (HP:0001876)1.85659626
102Abnormality of reticulocytes (HP:0004312)1.84882932
103Abnormality of the fingertips (HP:0001211)1.84769950
104Aplastic anemia (HP:0001915)1.84744539
105IgA deficiency (HP:0002720)1.83549517
106Long eyelashes (HP:0000527)1.83289427
107Nephroblastoma (Wilms tumor) (HP:0002667)1.82961172
108Rib fusion (HP:0000902)1.81422845
109Rough bone trabeculation (HP:0100670)1.80190070
110Squamous cell carcinoma (HP:0002860)1.78465614
111Horseshoe kidney (HP:0000085)1.75997915
112Abnormality of pyrimidine metabolism (HP:0004353)1.75704867
113Ovarian neoplasm (HP:0100615)1.75126805
114Cleft eyelid (HP:0000625)1.74752454
115Sandal gap (HP:0001852)1.74685024
116Cortical dysplasia (HP:0002539)1.74677086
117Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.74484241
118Abdominal situs inversus (HP:0003363)1.74410429
119Abnormality of abdominal situs (HP:0011620)1.74410429
120Clubbing of toes (HP:0100760)1.74077626
121Duplication of thumb phalanx (HP:0009942)1.73791913
122Short humerus (HP:0005792)1.72071394
123Increased density of long bones (HP:0006392)1.72069713
124Triphalangeal thumb (HP:0001199)1.70709813
125Abnormality of chromosome segregation (HP:0002916)1.69997052
126Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69489258
127Premature ovarian failure (HP:0008209)1.68579989
128Skull defect (HP:0001362)1.67903687
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.67477792
130Embryonal renal neoplasm (HP:0011794)1.66057365
131High anterior hairline (HP:0009890)1.64573562
132Deep philtrum (HP:0002002)1.60387000
133Partial agenesis of the corpus callosum (HP:0001338)1.59065514
134Macrocytic anemia (HP:0001972)1.56101511
135Pendular nystagmus (HP:0012043)1.52816268
136Facial asymmetry (HP:0000324)1.52602724
137Abnormality of methionine metabolism (HP:0010901)1.51980438
138Septate vagina (HP:0001153)1.51938384

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.78440288
2WEE13.62905004
3NEK23.33956259
4NEK13.14726144
5CDK123.02399808
6BUB13.00225577
7VRK22.54298599
8TTK2.50850387
9EEF2K2.38455426
10PBK2.26100197
11TAF12.19869878
12SRPK12.05830969
13NUAK11.99921305
14PASK1.96507461
15MAP3K101.90125109
16ATR1.89445493
17STK101.86970068
18PLK11.85902819
19RPS6KB21.84179079
20SMG11.77984747
21PKN21.76979365
22AURKB1.76891777
23ACVR1B1.74131538
24EIF2AK11.70991095
25MKNK11.70293301
26CDK71.68047755
27CDK41.63974492
28TSSK61.63033759
29PLK41.61622255
30STK41.56640269
31BRSK21.56556685
32MAP3K81.52606126
33TLK11.51831212
34VRK11.44605003
35BRD41.41534417
36MST41.41509334
37CHEK21.40141652
38FLT31.39293863
39TGFBR11.38968454
40NME21.38737416
41PLK31.38170348
42ZAK1.34054340
43RPS6KA41.33336285
44CHEK11.30321359
45SCYL21.25978125
46EPHA21.21939883
47CAMK1D1.20229305
48NME11.14746359
49PIM11.13620151
50AURKA1.09037812
51MAP4K11.06966340
52CDK61.06829131
53ATM1.06044882
54CAMK1G1.04552485
55CCNB11.02412288
56PAK41.01998878
57BMPR1B1.00823151
58DYRK31.00555328
59LRRK20.99121957
60CDK80.95524842
61TESK20.95099462
62EIF2AK30.93740659
63CDK20.92292014
64ALK0.90682343
65STK30.89220913
66MKNK20.87097319
67JAK30.85454071
68BRSK10.82583344
69PNCK0.82470497
70CLK10.82319123
71TTN0.80331625
72PDK20.79980580
73MELK0.78715854
74MTOR0.70063869
75TRIB30.69848367
76TRIM280.69758065
77BTK0.68615433
78CDK10.67710817
79GRK60.66905623
80MAP2K30.66897171
81TNIK0.66162211
82CSNK2A20.56738892
83PAK20.55305165
84CSF1R0.54788239
85TRPM70.53250446
86AKT20.53008853
87RPS6KA50.50825790
88MAPKAPK50.50805343
89PAK10.50322008
90EIF2AK20.49691662
91CSNK2A10.48707340
92PDGFRA0.47664242
93FRK0.46101025
94MAPK110.44515422
95NEK90.43722946
96LATS10.41141718
97PRKDC0.40493877
98FGFR10.40468064
99CSNK1D0.38659758
100IRAK20.37289879
101TYK20.37050832
102PTK60.36862018
103ZAP700.36351673
104PRKCI0.35974695
105TEC0.34991620
106ITK0.34750239
107CDK30.34353313
108MAPK140.33523854
109IRAK10.33304606
110AKT10.32887898
111STK160.32806385
112CHUK0.32117530
113MAPKAPK30.31871814
114GSK3B0.31300266
115MARK30.30165227
116CDK90.29415296
117OXSR10.28417839
118RPS6KC10.26852918
119RPS6KL10.26852918
120MAPK10.26786477
121CSNK1E0.25694630
122STK390.25201031
123KIT0.25188954
124RPS6KB10.24989463
125DAPK10.23825925
126BRAF0.19706952
127RAF10.19081128
128MST1R0.17748818

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17721002
2Mismatch repair_Homo sapiens_hsa034304.38324466
3Base excision repair_Homo sapiens_hsa034103.22231674
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16622385
5One carbon pool by folate_Homo sapiens_hsa006703.10154804
6Spliceosome_Homo sapiens_hsa030403.06634014
7RNA transport_Homo sapiens_hsa030132.98483575
8Homologous recombination_Homo sapiens_hsa034402.94458794
9Cell cycle_Homo sapiens_hsa041102.87983796
10Nucleotide excision repair_Homo sapiens_hsa034202.67896689
11Ribosome_Homo sapiens_hsa030102.53212445
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43632222
13Fanconi anemia pathway_Homo sapiens_hsa034602.39416585
14Non-homologous end-joining_Homo sapiens_hsa034502.20786171
15RNA polymerase_Homo sapiens_hsa030201.97574209
16Pyrimidine metabolism_Homo sapiens_hsa002401.90238650
17Systemic lupus erythematosus_Homo sapiens_hsa053221.81559362
18Proteasome_Homo sapiens_hsa030501.80262199
19mRNA surveillance pathway_Homo sapiens_hsa030151.79884666
20p53 signaling pathway_Homo sapiens_hsa041151.72405504
21RNA degradation_Homo sapiens_hsa030181.64872364
22Basal transcription factors_Homo sapiens_hsa030221.40617726
23Viral carcinogenesis_Homo sapiens_hsa052031.32556076
24Antigen processing and presentation_Homo sapiens_hsa046121.15840588
25Herpes simplex infection_Homo sapiens_hsa051681.15776433
26Epstein-Barr virus infection_Homo sapiens_hsa051691.14395860
27Protein export_Homo sapiens_hsa030601.03066925
28MicroRNAs in cancer_Homo sapiens_hsa052061.01864935
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01100193
30HTLV-I infection_Homo sapiens_hsa051661.00055252
31Small cell lung cancer_Homo sapiens_hsa052220.96717929
32Selenocompound metabolism_Homo sapiens_hsa004500.94548753
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93177476
34Pyruvate metabolism_Homo sapiens_hsa006200.92265989
35Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90024888
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86056573
37Primary immunodeficiency_Homo sapiens_hsa053400.84497205
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84460782
39Purine metabolism_Homo sapiens_hsa002300.83936887
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81582860
41Oocyte meiosis_Homo sapiens_hsa041140.80078489
42Legionellosis_Homo sapiens_hsa051340.79990007
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.77850425
44Apoptosis_Homo sapiens_hsa042100.77209785
45Chronic myeloid leukemia_Homo sapiens_hsa052200.77081402
46Thyroid cancer_Homo sapiens_hsa052160.73828687
47Propanoate metabolism_Homo sapiens_hsa006400.72882530
48Biosynthesis of amino acids_Homo sapiens_hsa012300.72215058
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.71616710
50Measles_Homo sapiens_hsa051620.62432689
51Lysine degradation_Homo sapiens_hsa003100.62363991
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61462352
53Alcoholism_Homo sapiens_hsa050340.60782769
54Pentose phosphate pathway_Homo sapiens_hsa000300.60771603
55Basal cell carcinoma_Homo sapiens_hsa052170.60439032
56Hepatitis B_Homo sapiens_hsa051610.59651747
57Notch signaling pathway_Homo sapiens_hsa043300.59302454
58Colorectal cancer_Homo sapiens_hsa052100.58981291
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58726807
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.58419649
61TGF-beta signaling pathway_Homo sapiens_hsa043500.56952908
62Huntingtons disease_Homo sapiens_hsa050160.56927966
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.55537549
64Hippo signaling pathway_Homo sapiens_hsa043900.54476769
65Sulfur relay system_Homo sapiens_hsa041220.54190393
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.52650174
67Vitamin B6 metabolism_Homo sapiens_hsa007500.52225120
68HIF-1 signaling pathway_Homo sapiens_hsa040660.52124249
69Viral myocarditis_Homo sapiens_hsa054160.51750580
70Adherens junction_Homo sapiens_hsa045200.51330082
71Steroid biosynthesis_Homo sapiens_hsa001000.50531081
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.50399964
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50307492
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49674330
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48022516
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47832422
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47742595
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47689565
79B cell receptor signaling pathway_Homo sapiens_hsa046620.47225753
80Folate biosynthesis_Homo sapiens_hsa007900.46784969
81Shigellosis_Homo sapiens_hsa051310.46416455
82Hematopoietic cell lineage_Homo sapiens_hsa046400.46059384
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45882365
84Acute myeloid leukemia_Homo sapiens_hsa052210.45096822
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.44866282
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44194449
87Bladder cancer_Homo sapiens_hsa052190.43507929
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42748832
89Pathways in cancer_Homo sapiens_hsa052000.42744795
90Influenza A_Homo sapiens_hsa051640.41499207
91Leishmaniasis_Homo sapiens_hsa051400.40078446
92Parkinsons disease_Homo sapiens_hsa050120.39558592
93Fatty acid elongation_Homo sapiens_hsa000620.38426673
94Proteoglycans in cancer_Homo sapiens_hsa052050.38053518
95Non-small cell lung cancer_Homo sapiens_hsa052230.37746911
96Prostate cancer_Homo sapiens_hsa052150.37542679
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.37003644
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36835716
99Pancreatic cancer_Homo sapiens_hsa052120.36575608
100Carbon metabolism_Homo sapiens_hsa012000.35259859
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35185795
102N-Glycan biosynthesis_Homo sapiens_hsa005100.34662157
103Metabolic pathways_Homo sapiens_hsa011000.33521288
104mTOR signaling pathway_Homo sapiens_hsa041500.33278097
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32889766
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31592209
107Fatty acid metabolism_Homo sapiens_hsa012120.31581089
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30805946
109Oxidative phosphorylation_Homo sapiens_hsa001900.30060355
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.29696101
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29692292
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29223917
113Toxoplasmosis_Homo sapiens_hsa051450.26171019
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26127131
115Glutathione metabolism_Homo sapiens_hsa004800.26084432
116Melanoma_Homo sapiens_hsa052180.25560348
117Hedgehog signaling pathway_Homo sapiens_hsa043400.22785890
118T cell receptor signaling pathway_Homo sapiens_hsa046600.22442118
119Renin-angiotensin system_Homo sapiens_hsa046140.22172050
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.21460245
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.21246155
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21042479
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20293267
124Vitamin digestion and absorption_Homo sapiens_hsa049770.19114083
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16097876
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.08410060
127Butanoate metabolism_Homo sapiens_hsa006500.07880836
128Wnt signaling pathway_Homo sapiens_hsa043100.07777823
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.06437411
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06388601
131Pentose and glucuronate interconversions_Homo sapiens_hsa000400.05352841
132Fructose and mannose metabolism_Homo sapiens_hsa000510.03371732

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