TTI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)4.82403224
2cytidine metabolic process (GO:0046087)4.82403224
3cytidine catabolic process (GO:0006216)4.82403224
4telomere maintenance via semi-conservative replication (GO:0032201)4.37126043
5DNA strand elongation involved in DNA replication (GO:0006271)4.31589115
6molting cycle (GO:0042303)4.30332869
7hair cycle (GO:0042633)4.30332869
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.30206801
9DNA replication initiation (GO:0006270)4.29910223
10DNA strand elongation (GO:0022616)4.25643530
11IMP biosynthetic process (GO:0006188)4.19561277
12DNA strand renaturation (GO:0000733)4.16362898
13pseudouridine synthesis (GO:0001522)4.14510149
14nuclear pore organization (GO:0006999)4.12067598
15pyrimidine ribonucleoside catabolic process (GO:0046133)4.09232696
16negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.01894833
17regulation of helicase activity (GO:0051095)3.96621042
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.94187151
19mitochondrial respiratory chain complex I assembly (GO:0032981)3.94187151
20NADH dehydrogenase complex assembly (GO:0010257)3.94187151
21nuclear pore complex assembly (GO:0051292)3.86257348
22DNA unwinding involved in DNA replication (GO:0006268)3.83333389
23tryptophan metabolic process (GO:0006568)3.82426996
24nucleobase biosynthetic process (GO:0046112)3.81088168
25protein complex biogenesis (GO:0070271)3.80085601
26purine nucleobase biosynthetic process (GO:0009113)3.80025124
27telomere maintenance via recombination (GO:0000722)3.76445985
28DNA deamination (GO:0045006)3.72199789
29regulation of nuclear cell cycle DNA replication (GO:0033262)3.68729342
30regulation of histone H3-K9 methylation (GO:0051570)3.68370376
31histone H2A acetylation (GO:0043968)3.68240030
32DNA-dependent DNA replication (GO:0006261)3.67438528
33tRNA methylation (GO:0030488)3.66548192
34mitotic sister chromatid cohesion (GO:0007064)3.61240324
35mitochondrial respiratory chain complex assembly (GO:0033108)3.59721218
36proteasome assembly (GO:0043248)3.59069367
37kinetochore organization (GO:0051383)3.58070681
38telomere maintenance via telomere lengthening (GO:0010833)3.57313042
39IMP metabolic process (GO:0046040)3.56517984
40indolalkylamine metabolic process (GO:0006586)3.55934713
41mitotic recombination (GO:0006312)3.54395537
42DNA replication checkpoint (GO:0000076)3.53303656
43ribosome biogenesis (GO:0042254)3.51447610
44water-soluble vitamin biosynthetic process (GO:0042364)3.49112730
45kinetochore assembly (GO:0051382)3.48146294
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.44722393
47kynurenine metabolic process (GO:0070189)3.43577567
48ribosome assembly (GO:0042255)3.42990219
49negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.38836463
50rRNA modification (GO:0000154)3.36653506
51sulfation (GO:0051923)3.35715493
52regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.32367355
53regulation of mitotic spindle checkpoint (GO:1903504)3.32367355
54meiotic chromosome segregation (GO:0045132)3.31237890
55mismatch repair (GO:0006298)3.27843578
56somatic hypermutation of immunoglobulin genes (GO:0016446)3.27154485
57somatic diversification of immune receptors via somatic mutation (GO:0002566)3.27154485
58nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24265012
59negative regulation of telomere maintenance (GO:0032205)3.22803499
60DNA geometric change (GO:0032392)3.22273527
61mitotic nuclear envelope disassembly (GO:0007077)3.21982746
62protein localization to kinetochore (GO:0034501)3.21330736
63DNA duplex unwinding (GO:0032508)3.20999273
64negative regulation by host of viral transcription (GO:0043922)3.20546970
65negative regulation of histone methylation (GO:0031061)3.20388007
66protein K6-linked ubiquitination (GO:0085020)3.19978093
67negative regulation of RNA splicing (GO:0033119)3.18779041
68rRNA methylation (GO:0031167)3.16987751
69folic acid-containing compound biosynthetic process (GO:0009396)3.16547567
70replicative senescence (GO:0090399)3.16221501
71negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15928572
72negative regulation of sister chromatid segregation (GO:0033046)3.15928572
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.15928572
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15928572
75chromatin remodeling at centromere (GO:0031055)3.14980378
76negative regulation of mast cell activation (GO:0033004)3.13744583
77transcription elongation from RNA polymerase I promoter (GO:0006362)3.13353652
78negative regulation of DNA-dependent DNA replication (GO:2000104)3.12106983
79regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11963986
80CENP-A containing nucleosome assembly (GO:0034080)3.11895141
81DNA double-strand break processing (GO:0000729)3.11660841
82translesion synthesis (GO:0019985)3.11239737
83telomere organization (GO:0032200)3.11063689
84negative regulation of chromosome segregation (GO:0051985)3.10874128
85pore complex assembly (GO:0046931)3.10814805
86indole-containing compound catabolic process (GO:0042436)3.08975260
87indolalkylamine catabolic process (GO:0046218)3.08975260
88tryptophan catabolic process (GO:0006569)3.08975260
89spindle assembly checkpoint (GO:0071173)3.08953801
90mitotic metaphase plate congression (GO:0007080)3.07599381
91DNA replication-independent nucleosome organization (GO:0034724)3.07530772
92DNA replication-independent nucleosome assembly (GO:0006336)3.07530772
93telomere maintenance (GO:0000723)3.06300539
94positive regulation of cAMP-mediated signaling (GO:0043950)3.05534912
95mitotic spindle assembly checkpoint (GO:0007094)3.05183586
96otic vesicle formation (GO:0030916)3.04160638
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.03203896
98replication fork processing (GO:0031297)3.03042077
99transcription-coupled nucleotide-excision repair (GO:0006283)3.02680797
100positive regulation of histone H3-K4 methylation (GO:0051571)3.01316340
101sister chromatid cohesion (GO:0007062)3.01289055
102DNA demethylation (GO:0080111)3.00897137
103nuclear envelope disassembly (GO:0051081)2.99858458
104membrane disassembly (GO:0030397)2.99858458
105DNA replication-dependent nucleosome organization (GO:0034723)2.99781312
106DNA replication-dependent nucleosome assembly (GO:0006335)2.99781312
107tRNA modification (GO:0006400)2.99567392
108piRNA metabolic process (GO:0034587)2.99405548
109formation of translation preinitiation complex (GO:0001731)2.98711123
110histone exchange (GO:0043486)2.97778483
111maturation of SSU-rRNA (GO:0030490)2.97662720
112histone mRNA catabolic process (GO:0071044)2.97180112
113recombinational repair (GO:0000725)2.96577329
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95707554
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95707554
116double-strand break repair via homologous recombination (GO:0000724)2.94659808
117somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93804849
118somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93804849
119isotype switching (GO:0045190)2.93804849
120attachment of spindle microtubules to kinetochore (GO:0008608)2.93550857
121positive regulation of T-helper 1 type immune response (GO:0002827)2.92971311
122deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91735432
123negative regulation of mRNA processing (GO:0050686)2.91521970
124negative regulation of systemic arterial blood pressure (GO:0003085)2.91295793
125RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90884643
126positive regulation of histone methylation (GO:0031062)2.90024415
127L-fucose catabolic process (GO:0042355)2.89449140
128fucose catabolic process (GO:0019317)2.89449140
129L-fucose metabolic process (GO:0042354)2.89449140
130mitochondrial DNA replication (GO:0006264)2.87674947
131spliceosomal snRNP assembly (GO:0000387)2.86897241
132metaphase plate congression (GO:0051310)2.86556260
133ribonucleoprotein complex biogenesis (GO:0022613)2.86516569
134mitotic spindle checkpoint (GO:0071174)2.85808046
135protein localization to chromosome, centromeric region (GO:0071459)2.85591686
136regulation of DNA endoreduplication (GO:0032875)2.85580920
137postreplication repair (GO:0006301)2.85090923
138spindle checkpoint (GO:0031577)2.84955636
139spliceosomal complex assembly (GO:0000245)2.83295869
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.81949481
141mRNA export from nucleus (GO:0006406)2.80712573
142DNA catabolic process, exonucleolytic (GO:0000738)2.80419781
143protein polyglutamylation (GO:0018095)2.79508528
144negative regulation of mRNA metabolic process (GO:1903312)2.79189629
145histone mRNA metabolic process (GO:0008334)2.78821414
146RNA modification (GO:0009451)2.78502523
147histone H2A monoubiquitination (GO:0035518)2.78386018
148dosage compensation (GO:0007549)2.77816374
149mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77612114
150RNA export from nucleus (GO:0006405)2.77587728
151rRNA processing (GO:0006364)2.77158506
152DNA synthesis involved in DNA repair (GO:0000731)2.76621887
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.76473938
154DNA replication (GO:0006260)2.75831485
155RNA splicing, via transesterification reactions (GO:0000375)2.74096806
156respiratory chain complex IV assembly (GO:0008535)2.74044822
157DNA dealkylation (GO:0035510)2.72727132
158GPI anchor metabolic process (GO:0006505)2.70818142
159positive regulation of digestive system process (GO:0060456)2.68325560
160termination of RNA polymerase I transcription (GO:0006363)2.67091030
161metallo-sulfur cluster assembly (GO:0031163)2.66086792
162iron-sulfur cluster assembly (GO:0016226)2.66086792
163preassembly of GPI anchor in ER membrane (GO:0016254)2.64390164
164mannosylation (GO:0097502)2.63969232
165behavioral response to nicotine (GO:0035095)2.62855274
166response to pheromone (GO:0019236)2.62362115
167L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55670520
168transcription elongation from RNA polymerase III promoter (GO:0006385)2.52710168
169termination of RNA polymerase III transcription (GO:0006386)2.52710168
170DNA integration (GO:0015074)2.52070237
171positive regulation of T cell chemotaxis (GO:0010820)2.51164233
172regulation of T cell chemotaxis (GO:0010819)2.51164233
173cytochrome complex assembly (GO:0017004)2.50652110
174positive regulation of defense response to virus by host (GO:0002230)2.50019220
175response to UV-C (GO:0010225)2.48269209
176tRNA processing (GO:0008033)2.48243980
177synapsis (GO:0007129)2.46559577
178negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46222589
179T cell mediated immunity (GO:0002456)2.45092622
180reciprocal meiotic recombination (GO:0007131)2.44639680
181reciprocal DNA recombination (GO:0035825)2.44639680
182somatic diversification of immunoglobulins (GO:0016445)2.43949249
183ATP synthesis coupled proton transport (GO:0015986)2.41272807
184energy coupled proton transport, down electrochemical gradient (GO:0015985)2.41272807
185ubiquinone biosynthetic process (GO:0006744)2.41061578
186pyrimidine dimer repair (GO:0006290)2.39266148
187mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.36374904
188nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.36066207
189DNA methylation involved in gamete generation (GO:0043046)2.35750813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.36843385
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.38043148
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.82180656
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.75420297
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.11901050
6ZNF274_21170338_ChIP-Seq_K562_Hela3.11323978
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00421950
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.76733562
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73869710
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.72568953
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.70402156
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.65066598
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.64363986
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63312490
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62594843
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57559004
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.56461684
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53651535
19VDR_23849224_ChIP-Seq_CD4+_Human2.47602794
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34152507
21KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26460423
22FOXP3_21729870_ChIP-Seq_TREG_Human2.25591395
23* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21463973
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21204865
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20079986
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.19144628
27CIITA_25753668_ChIP-Seq_RAJI_Human2.18300652
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17875821
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16298842
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.13588565
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09071141
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08666852
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07218055
34EGR1_19374776_ChIP-ChIP_THP-1_Human2.04604112
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01914995
36XRN2_22483619_ChIP-Seq_HELA_Human2.00864092
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00044587
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93193711
39VDR_22108803_ChIP-Seq_LS180_Human1.91799746
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89778926
41EWS_26573619_Chip-Seq_HEK293_Human1.88755917
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87903097
43GABP_19822575_ChIP-Seq_HepG2_Human1.87691921
44IGF1R_20145208_ChIP-Seq_DFB_Human1.87251123
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83961874
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.82722898
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82035648
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78850998
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78711268
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.78585505
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73811707
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.72999122
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72714521
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72255736
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.61054435
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60204486
57FUS_26573619_Chip-Seq_HEK293_Human1.59627295
58DCP1A_22483619_ChIP-Seq_HELA_Human1.59198054
59MYC_22102868_ChIP-Seq_BL_Human1.57332350
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56940409
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56818767
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.55790820
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.55504616
64KDM5A_27292631_Chip-Seq_BREAST_Human1.55061380
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53976356
66ELK1_19687146_ChIP-ChIP_HELA_Human1.53791022
67TTF2_22483619_ChIP-Seq_HELA_Human1.53201540
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52442511
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51098665
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50244150
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47087701
72ER_23166858_ChIP-Seq_MCF-7_Human1.45857699
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.41223183
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.38624569
75SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37850124
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37773491
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.36406893
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36146831
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34847386
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34229645
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33791164
82AR_21909140_ChIP-Seq_LNCAP_Human1.31271118
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26590630
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26130016
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24740218
86E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22029515
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.20201572
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19526825
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.17583707
90GATA1_22025678_ChIP-Seq_K562_Human1.17426121
91TP53_22573176_ChIP-Seq_HFKS_Human1.16519709
92P300_19829295_ChIP-Seq_ESCs_Human1.16401892
93TAF15_26573619_Chip-Seq_HEK293_Human1.15669480
94PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14061924
95SPI1_23547873_ChIP-Seq_NB4_Human1.13049719
96CBP_20019798_ChIP-Seq_JUKART_Human1.12607787
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12607787
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11793324
99TFEB_21752829_ChIP-Seq_HELA_Human1.11350467
100SALL1_21062744_ChIP-ChIP_HESCs_Human1.10854921
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10610622
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10323602
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06174144
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01724544
105IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01696575
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01045920
107SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00851419
108FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99889741
109FOXA1_25329375_ChIP-Seq_VCAP_Human0.99889741
110PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98690797
111BCAT_22108803_ChIP-Seq_LS180_Human0.97455906
112CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97225410
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96353587
114GBX2_23144817_ChIP-Seq_PC3_Human0.96292303
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95148858
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95121285
117NANOG_19829295_ChIP-Seq_ESCs_Human0.94687580
118SOX2_19829295_ChIP-Seq_ESCs_Human0.94687580
119GATA3_26560356_Chip-Seq_TH2_Human0.93400814
120SCL_19346495_ChIP-Seq_HPC-7_Human0.93103592
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90569548
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89713014
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89342044
124MYB_26560356_Chip-Seq_TH1_Human0.88182909
125HOXB7_26014856_ChIP-Seq_BT474_Human0.87929562
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87670586
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87028635
128NFE2_27457419_Chip-Seq_LIVER_Mouse0.86963962
129MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86019102
130KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85844905
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85400041
132AR_20517297_ChIP-Seq_VCAP_Human0.85376182
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85326213
134MYC_18940864_ChIP-ChIP_HL60_Human0.84515567
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.83431885
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.83016410
137SALL4_22934838_ChIP-ChIP_CD34+_Human0.82568508
138EZH2_27294783_Chip-Seq_NPCs_Mouse0.82487085
139MYB_26560356_Chip-Seq_TH2_Human0.81540441
140FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80331008
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80296588
142FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80125666
143NCOR_22424771_ChIP-Seq_293T_Human0.80008229
144FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77477297
145ELK1_22589737_ChIP-Seq_MCF10A_Human0.77281935
146CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75735180
147AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75691775
148AUTS2_25519132_ChIP-Seq_293T-REX_Human0.74763579
149TCF4_22108803_ChIP-Seq_LS180_Human0.74264720
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73816064
151RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.72817195
152VDR_21846776_ChIP-Seq_THP-1_Human0.72617128
153PKCTHETA_26484144_Chip-Seq_BREAST_Human0.68217649
154IRF1_19129219_ChIP-ChIP_H3396_Human0.67585533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.59681729
2MP0010094_abnormal_chromosome_stability4.58882286
3MP0008057_abnormal_DNA_replication4.47770725
4MP0003693_abnormal_embryo_hatching4.28335242
5MP0008058_abnormal_DNA_repair4.12348210
6MP0003077_abnormal_cell_cycle3.48630598
7MP0004957_abnormal_blastocyst_morpholog3.36366624
8MP0008877_abnormal_DNA_methylation3.26593335
9MP0002396_abnormal_hematopoietic_system3.13644771
10MP0000372_irregular_coat_pigmentation3.07430943
11MP0006292_abnormal_olfactory_placode2.70803525
12MP0005083_abnormal_biliary_tract2.64090324
13MP0008007_abnormal_cellular_replicative2.56803150
14MP0002102_abnormal_ear_morphology2.55372190
15MP0009697_abnormal_copulation2.45463926
16MP0004808_abnormal_hematopoietic_stem2.11913809
17MP0005645_abnormal_hypothalamus_physiol2.09055041
18MP0000490_abnormal_crypts_of2.08368603
19MP0003786_premature_aging2.04904812
20MP0005171_absent_coat_pigmentation1.98031646
21MP0008872_abnormal_physiological_respon1.94196411
22MP0003787_abnormal_imprinting1.92181797
23MP0003763_abnormal_thymus_physiology1.88754853
24MP0003195_calcinosis1.85635158
25MP0000383_abnormal_hair_follicle1.82673215
26MP0003121_genomic_imprinting1.81274192
27MP0000350_abnormal_cell_proliferation1.79722871
28MP0001730_embryonic_growth_arrest1.75234828
29MP0003890_abnormal_embryonic-extraembry1.69167039
30MP0005253_abnormal_eye_physiology1.65206234
31MP0008932_abnormal_embryonic_tissue1.64187668
32MP0001986_abnormal_taste_sensitivity1.64167516
33MP0002254_reproductive_system_inflammat1.58961201
34MP0002398_abnormal_bone_marrow1.57517235
35MP0000703_abnormal_thymus_morphology1.55782235
36MP0002736_abnormal_nociception_after1.55770292
37MP0005671_abnormal_response_to1.52975204
38MP0001545_abnormal_hematopoietic_system1.51847082
39MP0005397_hematopoietic_system_phenotyp1.51847082
40MP0005551_abnormal_eye_electrophysiolog1.49791489
41MP0002095_abnormal_skin_pigmentation1.49396278
42MP0001968_abnormal_touch/_nociception1.48369907
43MP0001188_hyperpigmentation1.45697011
44MP0003718_maternal_effect1.44596586
45MP0010307_abnormal_tumor_latency1.44458574
46MP0004133_heterotaxia1.43683947
47MP0000313_abnormal_cell_death1.42429352
48MP0002722_abnormal_immune_system1.37319973
49MP0005174_abnormal_tail_pigmentation1.37093327
50MP0000689_abnormal_spleen_morphology1.36364358
51MP0001764_abnormal_homeostasis1.35782874
52MP0002019_abnormal_tumor_incidence1.35694511
53MP0003567_abnormal_fetal_cardiomyocyte1.35329047
54MP0001672_abnormal_embryogenesis/_devel1.34408901
55MP0005380_embryogenesis_phenotype1.34408901
56MP0002080_prenatal_lethality1.34281083
57MP0002210_abnormal_sex_determination1.32271276
58MP0000613_abnormal_salivary_gland1.31839525
59MP0001697_abnormal_embryo_size1.30710823
60MP0002938_white_spotting1.27501651
61MP0005410_abnormal_fertilization1.23417488
62MP0003123_paternal_imprinting1.23128697
63MP0002085_abnormal_embryonic_tissue1.21838106
64MP0001929_abnormal_gametogenesis1.20026669
65MP0000427_abnormal_hair_cycle1.18733372
66MP0001919_abnormal_reproductive_system1.18448118
67MP0000015_abnormal_ear_pigmentation1.17337949
68MP0002084_abnormal_developmental_patter1.17252415
69MP0003984_embryonic_growth_retardation1.16482246
70MP0005646_abnormal_pituitary_gland1.15957275
71MP0005084_abnormal_gallbladder_morpholo1.13359195
72MP0001145_abnormal_male_reproductive1.11242001
73MP0001293_anophthalmia1.11143840
74MP0009333_abnormal_splenocyte_physiolog1.10873124
75MP0002088_abnormal_embryonic_growth/wei1.10686193
76MP0009672_abnormal_birth_weight1.09315965
77MP0002429_abnormal_blood_cell1.08135607
78MP0005075_abnormal_melanosome_morpholog1.07695240
79MP0000716_abnormal_immune_system1.07383931
80MP0009703_decreased_birth_body1.06853580
81MP0002163_abnormal_gland_morphology1.06447382
82MP0002282_abnormal_trachea_morphology1.02789939
83MP0006035_abnormal_mitochondrial_morpho1.02358175
84MP0004142_abnormal_muscle_tone1.01673487
85MP0001243_abnormal_dermal_layer1.01012149
86MP0001800_abnormal_humoral_immune1.00645100
87MP0000631_abnormal_neuroendocrine_gland1.00643865
88MP0005220_abnormal_exocrine_pancreas1.00398728
89MP0009278_abnormal_bone_marrow0.99157205
90MP0004197_abnormal_fetal_growth/weight/0.98929487
91MP0003646_muscle_fatigue0.98783386
92MP0004147_increased_porphyrin_level0.98603162
93MP0002089_abnormal_postnatal_growth/wei0.97839144
94MP0002086_abnormal_extraembryonic_tissu0.96310791
95MP0008260_abnormal_autophagy0.96186256
96MP0000685_abnormal_immune_system0.95498688
97MP0000653_abnormal_sex_gland0.95194266
98MP0002075_abnormal_coat/hair_pigmentati0.94015634
99MP0000569_abnormal_digit_pigmentation0.93310236
100MP0005384_cellular_phenotype0.93234718
101MP0003937_abnormal_limbs/digits/tail_de0.92525591
102MP0009764_decreased_sensitivity_to0.92188161
103MP0003866_abnormal_defecation0.91678344
104MP0002166_altered_tumor_susceptibility0.91344604
105MP0000049_abnormal_middle_ear0.90853257
106MP0001485_abnormal_pinna_reflex0.89807170
107MP0000371_diluted_coat_color0.89770328
108MP0010352_gastrointestinal_tract_polyps0.89566596
109MP0008789_abnormal_olfactory_epithelium0.88878861
110MP0004134_abnormal_chest_morphology0.88381841
111MP0006072_abnormal_retinal_apoptosis0.87829161
112MP0002638_abnormal_pupillary_reflex0.87265297
113MP0005621_abnormal_cell_physiology0.85936351
114MP0002928_abnormal_bile_duct0.84815820
115MP0003698_abnormal_male_reproductive0.84256711
116MP0003868_abnormal_feces_composition0.82921443
117MP0002009_preneoplasia0.82844457
118MP0005503_abnormal_tendon_morphology0.81783680
119MP0002837_dystrophic_cardiac_calcinosis0.81623376
120MP0000358_abnormal_cell_content/0.80527200
121MP0001790_abnormal_immune_system0.80061623
122MP0005387_immune_system_phenotype0.80061623
123MP0001873_stomach_inflammation0.79451493
124MP0002420_abnormal_adaptive_immunity0.78593814
125MP0008875_abnormal_xenobiotic_pharmacok0.78577462
126MP0002751_abnormal_autonomic_nervous0.78492419
127MP0008995_early_reproductive_senescence0.76998331
128MP0002160_abnormal_reproductive_system0.76924848
129MP0001819_abnormal_immune_cell0.76455054
130MP0005000_abnormal_immune_tolerance0.75342100
131MP0001984_abnormal_olfaction0.72971101
132MP0002933_joint_inflammation0.72851091
133MP0003283_abnormal_digestive_organ0.71732345
134MP0010678_abnormal_skin_adnexa0.71509709
135MP0002006_tumorigenesis0.71469548
136MP0009785_altered_susceptibility_to0.71312951
137MP0002876_abnormal_thyroid_physiology0.71307211
138MP0005379_endocrine/exocrine_gland_phen0.70950010
139MP0001186_pigmentation_phenotype0.70531640
140MP0002138_abnormal_hepatobiliary_system0.69141954
141MP0001119_abnormal_female_reproductive0.68504459
142MP0002148_abnormal_hypersensitivity_rea0.68355579
143MP0003638_abnormal_response/metabolism_0.67661247
144MP0003252_abnormal_bile_duct0.67342771
145MP0003806_abnormal_nucleotide_metabolis0.67290824
146MP0002653_abnormal_ependyma_morphology0.66732468
147MP0001835_abnormal_antigen_presentation0.66226371
148MP0002139_abnormal_hepatobiliary_system0.66133069
149MP0002723_abnormal_immune_serum0.66096941
150MP0002693_abnormal_pancreas_physiology0.65810136
151MP0005389_reproductive_system_phenotype0.65106480
152MP0005423_abnormal_somatic_nervous0.64856083
153MP0002111_abnormal_tail_morphology0.63601490
154MP0002452_abnormal_antigen_presenting0.63139527
155MP0003136_yellow_coat_color0.63130811
156MP0002132_abnormal_respiratory_system0.61635444

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38769992
2Chromsome breakage (HP:0040012)4.30620136
3Birth length less than 3rd percentile (HP:0003561)4.08437031
4Abnormality of chromosome stability (HP:0003220)3.53187744
5IgM deficiency (HP:0002850)3.52277090
6Meckel diverticulum (HP:0002245)3.32275263
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.27613965
8Myelodysplasia (HP:0002863)3.21819010
9Abnormality of the preputium (HP:0100587)3.20448204
10Medulloblastoma (HP:0002885)3.15479510
11Neoplasm of the heart (HP:0100544)3.11913325
12Abnormality of the ileum (HP:0001549)3.11415282
13Hepatocellular necrosis (HP:0001404)3.10692974
14True hermaphroditism (HP:0010459)3.08154427
15Abolished electroretinogram (ERG) (HP:0000550)3.06117167
163-Methylglutaconic aciduria (HP:0003535)2.95016552
17Volvulus (HP:0002580)2.89440556
18Short phalanx of the thumb (HP:0009660)2.87419359
19Reticulocytopenia (HP:0001896)2.87043886
20Type I transferrin isoform profile (HP:0003642)2.84742338
21Aplastic anemia (HP:0001915)2.83238642
22Mitochondrial inheritance (HP:0001427)2.80682135
23Pendular nystagmus (HP:0012043)2.80054075
24Cerebellar dysplasia (HP:0007033)2.79164569
25Increased nuchal translucency (HP:0010880)2.74948096
26Abnormality of midbrain morphology (HP:0002418)2.74122710
27Molar tooth sign on MRI (HP:0002419)2.74122710
28Hypothermia (HP:0002045)2.74083824
29Bone marrow hypocellularity (HP:0005528)2.73739471
30Oral leukoplakia (HP:0002745)2.71273100
31Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70486511
32Type II lissencephaly (HP:0007260)2.68741700
33Duplicated collecting system (HP:0000081)2.68106331
34Neoplasm of the oral cavity (HP:0100649)2.66532854
35Hepatic necrosis (HP:0002605)2.64672680
36Increased CSF lactate (HP:0002490)2.63521050
37* Prominent nose (HP:0000448)2.62254833
38Short 4th metacarpal (HP:0010044)2.60768262
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60768262
40Selective tooth agenesis (HP:0001592)2.59586958
41Abnormality of the renal cortex (HP:0011035)2.58274631
42Rough bone trabeculation (HP:0100670)2.56753063
43Impulsivity (HP:0100710)2.55818171
44Abnormality of the carotid arteries (HP:0005344)2.54871338
45Absent thumb (HP:0009777)2.50509417
46* Sloping forehead (HP:0000340)2.50078771
47Ectopic kidney (HP:0000086)2.50024293
48Abnormality of DNA repair (HP:0003254)2.48077973
49Colon cancer (HP:0003003)2.47252210
50Abnormal spermatogenesis (HP:0008669)2.46599553
51Abnormal protein N-linked glycosylation (HP:0012347)2.44930249
52Abnormal protein glycosylation (HP:0012346)2.44930249
53Abnormal glycosylation (HP:0012345)2.44930249
54Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.44930249
55Pancreatic cysts (HP:0001737)2.44206551
56Abnormality of the renal collecting system (HP:0004742)2.43857960
57Clubbing of toes (HP:0100760)2.43686753
58Abnormality of the parietal bone (HP:0002696)2.43252890
59Duodenal stenosis (HP:0100867)2.42827322
60Small intestinal stenosis (HP:0012848)2.42827322
61Attenuation of retinal blood vessels (HP:0007843)2.41221335
62Cerebral hypomyelination (HP:0006808)2.40750965
63Medial flaring of the eyebrow (HP:0010747)2.40515906
64Concave nail (HP:0001598)2.40494176
65Lymphoma (HP:0002665)2.39659093
66Hypoplastic pelvis (HP:0008839)2.39538512
67Hypoplasia of the pons (HP:0012110)2.38648980
68Absent radius (HP:0003974)2.37811009
69Cafe-au-lait spot (HP:0000957)2.37645450
70Basal cell carcinoma (HP:0002671)2.35194470
71Abnormality of the pons (HP:0007361)2.34356324
72Lipid accumulation in hepatocytes (HP:0006561)2.33586513
73Anal stenosis (HP:0002025)2.33388302
74Abnormality of the fingertips (HP:0001211)2.33230147
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.29280647
76Hypoproteinemia (HP:0003075)2.28994719
77Thyroiditis (HP:0100646)2.26378829
78Renal cortical cysts (HP:0000803)2.26149515
79Down-sloping shoulders (HP:0200021)2.25153458
80Microretrognathia (HP:0000308)2.24118987
81Increased corneal curvature (HP:0100692)2.23696644
82Keratoconus (HP:0000563)2.23696644
83Abnormality of the labia minora (HP:0012880)2.23236013
84Abnormal number of incisors (HP:0011064)2.23048075
85Increased serum lactate (HP:0002151)2.22987127
86Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21666666
87Patellar aplasia (HP:0006443)2.19048123
88Thyroid-stimulating hormone excess (HP:0002925)2.18784609
89Type 2 muscle fiber atrophy (HP:0003554)2.18708124
90Decreased central vision (HP:0007663)2.18664954
91Nephronophthisis (HP:0000090)2.18292525
92Severe visual impairment (HP:0001141)2.18052379
93Thrombocytosis (HP:0001894)2.17958841
94Congenital stationary night blindness (HP:0007642)2.17521799
95Aplasia involving forearm bones (HP:0009822)2.16968388
96Absent forearm bone (HP:0003953)2.16968388
97Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.16204298
98Acute necrotizing encephalopathy (HP:0006965)2.16100076
99Cellular immunodeficiency (HP:0005374)2.14401041
100Abnormality of the heme biosynthetic pathway (HP:0010472)2.12704054
101Neoplasm of the pancreas (HP:0002894)2.11757837
102Abnormality of the 4th metacarpal (HP:0010012)2.11670106
103CNS hypomyelination (HP:0003429)2.11420440
104Abnormality of the duodenum (HP:0002246)2.11298028
105Deformed sella turcica (HP:0002681)2.11281854
106Methylmalonic acidemia (HP:0002912)2.10737402
107Abnormal number of erythroid precursors (HP:0012131)2.07819622
108Muscle fiber atrophy (HP:0100295)2.07811656
109Abnormal rod and cone electroretinograms (HP:0008323)2.07217881
110Abnormality of abdominal situs (HP:0011620)2.06898175
111Abdominal situs inversus (HP:0003363)2.06898175
112Increased hepatocellular lipid droplets (HP:0006565)2.06005197
113Breast hypoplasia (HP:0003187)2.05822655
114Supernumerary spleens (HP:0009799)2.02726725
115Aplasia/Hypoplasia of the tibia (HP:0005772)2.01600277
116Abnormal mitochondria in muscle tissue (HP:0008316)2.00920230
117Premature graying of hair (HP:0002216)2.00482001
118Short thumb (HP:0009778)1.97664361
119Pancytopenia (HP:0001876)1.97498693
120Abnormality of the proximal phalanges of the hand (HP:0009834)1.97417364
121Azoospermia (HP:0000027)1.97252649
122Ependymoma (HP:0002888)1.97143756
123Stomach cancer (HP:0012126)1.97002370
124Glioma (HP:0009733)1.96250006
125Degeneration of anterior horn cells (HP:0002398)1.95968592
126Abnormality of the anterior horn cell (HP:0006802)1.95968592
127Fibular hypoplasia (HP:0003038)1.94999919
128Abnormal biliary tract physiology (HP:0012439)1.94647967
129Bile duct proliferation (HP:0001408)1.94647967
130Prostate neoplasm (HP:0100787)1.94532645
131Abnormality of T cells (HP:0002843)1.94458973
132Amaurosis fugax (HP:0100576)1.93650005
133Pancreatic fibrosis (HP:0100732)1.93451444
134Acute encephalopathy (HP:0006846)1.92973248
135Decreased electroretinogram (ERG) amplitude (HP:0000654)1.92972190
136Short tibia (HP:0005736)1.91300728
137Methylmalonic aciduria (HP:0012120)1.90988735
138Severe combined immunodeficiency (HP:0004430)1.90817297
139Abnormality of B cell number (HP:0010975)1.90286350
140B lymphocytopenia (HP:0010976)1.90286350
141Aplasia/Hypoplasia of the patella (HP:0006498)1.89960856
142Optic nerve coloboma (HP:0000588)1.89304012
143Vertebral fusion (HP:0002948)1.89143036
144Tubular atrophy (HP:0000092)1.88549975
145Long eyelashes (HP:0000527)1.87399314
146Triphalangeal thumb (HP:0001199)1.86807430
147Abnormality of the renal medulla (HP:0100957)1.86681991
148Hemivertebrae (HP:0002937)1.86313152
149Nephroblastoma (Wilms tumor) (HP:0002667)1.86176171
150Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85948525
151Abnormality of alanine metabolism (HP:0010916)1.85948525
152Hyperalaninemia (HP:0003348)1.85948525
153Abnormality of cells of the erythroid lineage (HP:0012130)1.83764635
154Lymphopenia (HP:0001888)1.82413816
155Reduced antithrombin III activity (HP:0001976)1.81377735
156Panhypogammaglobulinemia (HP:0003139)1.81293786
157Sclerocornea (HP:0000647)1.80020995
158Progressive macrocephaly (HP:0004481)1.79744482
15911 pairs of ribs (HP:0000878)1.79330797
160Lactic acidosis (HP:0003128)1.78436437
161Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78301710
162Hypoalbuminemia (HP:0003073)1.77058220
163Abnormal albumin level (HP:0012116)1.77058220
164Neoplasm of the colon (HP:0100273)1.77001124
165Congenital hepatic fibrosis (HP:0002612)1.76780007
166Tracheoesophageal fistula (HP:0002575)1.76005394
167Abnormal lung lobation (HP:0002101)1.75828502
168Biliary tract neoplasm (HP:0100574)1.75289870
169IgG deficiency (HP:0004315)1.74224641
170Leukopenia (HP:0001882)1.72311702
171Acute myeloid leukemia (HP:0004808)1.72064745
172Horseshoe kidney (HP:0000085)1.69985558

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.09231394
2BMPR1B4.02161113
3SRPK13.82856659
4STK163.79259867
5CDC73.27711313
6WEE12.93452246
7ZAK2.63840644
8MAP4K22.59496029
9TTK2.50217852
10NEK22.47288278
11BUB12.20517755
12FRK2.18436906
13MKNK22.06327984
14MST42.04272058
15IRAK31.98001568
16ATR1.96597921
17TLK11.93310038
18NEK11.89600966
19VRK21.83924877
20PASK1.83627034
21TSSK61.76052781
22SCYL21.74688049
23DYRK31.73797826
24TAOK31.71427523
25BRD41.71205740
26WNK31.70368603
27EIF2AK31.67246777
28MAP4K11.56449359
29CHEK21.56358236
30BRSK21.54525115
31CDK121.46292394
32PLK11.43390403
33MKNK11.43204632
34TNK21.35753189
35CDK191.34249515
36KDR1.33370040
37VRK11.33108946
38ACVR1B1.32564312
39NLK1.31640471
40BCKDK1.31613987
41PBK1.30514266
42CDK71.30231593
43MAP3K41.29319467
44BLK1.28063041
45CCNB11.27666575
46EIF2AK11.27376570
47AURKB1.19854136
48RPS6KB21.18918358
49CHEK11.10027624
50TRIM281.09634070
51RPS6KA41.09420755
52FLT31.02908319
53ATM1.01774077
54IRAK10.97730239
55TXK0.97391832
56BTK0.97321045
57EIF2AK20.97000649
58PLK40.96179708
59TGFBR10.95524696
60YES10.95521625
61PINK10.95366409
62PKN10.95163272
63CAMKK20.93488769
64DAPK30.91050196
65IRAK40.90884599
66TAF10.90550083
67INSRR0.90494451
68CLK10.90256995
69MUSK0.88154002
70CDK40.88028511
71PLK30.85714932
72IKBKB0.85311225
73EPHA20.83896659
74STK40.83697550
75CDK20.83196060
76PRKCQ0.83023432
77TEC0.81107142
78SGK20.80263047
79IRAK20.76806581
80STK38L0.76162635
81TESK20.75718632
82NME20.75616572
83PIM10.73777200
84JAK30.72903407
85CDK80.72385344
86MAP2K70.72380889
87MAPK130.71652474
88STK30.70972190
89AKT20.70128811
90KIT0.69562310
91RPS6KB10.69552193
92CSNK1G20.67972083
93ERBB30.67618398
94CSNK1A1L0.66389736
95CDK10.64439253
96PDK20.64409273
97OXSR10.63529425
98CSF1R0.63114052
99PRKCI0.62604171
100GRK70.62007183
101ALK0.61945090
102DAPK10.61129424
103CSNK2A20.59896537
104AURKA0.59408384
105NME10.59272801
106CDK30.58703366
107ZAP700.58475415
108ADRBK20.58139337
109ITK0.57513636
110GRK10.55303433
111EEF2K0.55296105
112NTRK20.55293036
113BRSK10.54385596
114MAP3K80.54113070
115HIPK20.53658506
116SGK30.52499469
117DYRK20.51862823
118ADRBK10.51147223
119PRKDC0.51027488
120STK390.50778369
121CDK60.50746848
122CSNK1G10.49076877
123MAPKAPK50.48955207
124EPHA30.47989209
125PNCK0.46657818
126SYK0.46420902
127CSNK1G30.46414154
128MAP3K110.45603705
129NUAK10.44188824
130RPS6KA50.43815669
131AKT30.43694127
132WNK40.41437459
133PRKCE0.40129466
134DAPK20.39691900
135GRK60.38564794
136DYRK1A0.38410102
137STK100.37350346
138TAOK20.36891272
139IKBKE0.36654633
140MELK0.36409461
141GSK3B0.36351683
142AKT10.36332743
143CSNK2A10.36266687
144MAPK140.36187699
145PRKCG0.34838385
146TIE10.31939853
147NEK90.30629049
148MARK30.29499781
149OBSCN0.27962934
150LYN0.26863980
151CSNK1A10.26312851

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.68661632
2Mismatch repair_Homo sapiens_hsa034304.47279927
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.65286848
4Homologous recombination_Homo sapiens_hsa034403.37104080
5Spliceosome_Homo sapiens_hsa030403.13701592
6RNA polymerase_Homo sapiens_hsa030203.07618852
7Fanconi anemia pathway_Homo sapiens_hsa034603.04645702
8Base excision repair_Homo sapiens_hsa034102.92726492
9RNA transport_Homo sapiens_hsa030132.72414050
10Nucleotide excision repair_Homo sapiens_hsa034202.68769368
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67960637
12One carbon pool by folate_Homo sapiens_hsa006702.43907741
13Cell cycle_Homo sapiens_hsa041102.40966664
14Pyrimidine metabolism_Homo sapiens_hsa002402.35634949
15Oxidative phosphorylation_Homo sapiens_hsa001902.35100554
16Non-homologous end-joining_Homo sapiens_hsa034502.22934273
17mRNA surveillance pathway_Homo sapiens_hsa030152.15787259
18RNA degradation_Homo sapiens_hsa030182.12701686
19Basal transcription factors_Homo sapiens_hsa030222.03232727
20Parkinsons disease_Homo sapiens_hsa050121.93817775
21Ribosome_Homo sapiens_hsa030101.86848335
22Proteasome_Homo sapiens_hsa030501.60419381
23Systemic lupus erythematosus_Homo sapiens_hsa053221.45714612
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44736598
25p53 signaling pathway_Homo sapiens_hsa041151.44349922
26Purine metabolism_Homo sapiens_hsa002301.42844658
27Huntingtons disease_Homo sapiens_hsa050161.37356704
28Nitrogen metabolism_Homo sapiens_hsa009101.37037233
29Protein export_Homo sapiens_hsa030601.34484667
30N-Glycan biosynthesis_Homo sapiens_hsa005101.27039311
31Herpes simplex infection_Homo sapiens_hsa051681.26988558
32Primary immunodeficiency_Homo sapiens_hsa053401.25745409
33Graft-versus-host disease_Homo sapiens_hsa053321.25185928
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23644914
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22385086
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16295195
37Autoimmune thyroid disease_Homo sapiens_hsa053201.13934940
38Tryptophan metabolism_Homo sapiens_hsa003801.12987061
39Epstein-Barr virus infection_Homo sapiens_hsa051691.12583803
40Propanoate metabolism_Homo sapiens_hsa006401.11217626
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10781348
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09897556
43Allograft rejection_Homo sapiens_hsa053301.09207583
44Alzheimers disease_Homo sapiens_hsa050101.08782458
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07160566
46Linoleic acid metabolism_Homo sapiens_hsa005911.06210705
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04191995
48Caffeine metabolism_Homo sapiens_hsa002321.03846640
49Vitamin B6 metabolism_Homo sapiens_hsa007501.03127654
50Peroxisome_Homo sapiens_hsa041460.99884493
51Viral carcinogenesis_Homo sapiens_hsa052030.99582438
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98947011
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98738193
54Oocyte meiosis_Homo sapiens_hsa041140.96365990
55Thyroid cancer_Homo sapiens_hsa052160.95990566
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92467264
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.91739640
58Butanoate metabolism_Homo sapiens_hsa006500.91728083
59Alcoholism_Homo sapiens_hsa050340.88994583
60Sulfur relay system_Homo sapiens_hsa041220.88081190
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87203243
62Measles_Homo sapiens_hsa051620.86306977
63Type I diabetes mellitus_Homo sapiens_hsa049400.83802570
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.78340057
65Hedgehog signaling pathway_Homo sapiens_hsa043400.77225699
66Antigen processing and presentation_Homo sapiens_hsa046120.76580685
67Acute myeloid leukemia_Homo sapiens_hsa052210.75232724
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72945728
69Selenocompound metabolism_Homo sapiens_hsa004500.72641631
70Fatty acid elongation_Homo sapiens_hsa000620.72150926
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68173425
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66551439
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65298469
74Ether lipid metabolism_Homo sapiens_hsa005650.64870153
75HTLV-I infection_Homo sapiens_hsa051660.63888703
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.61781874
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61469937
78Lysine degradation_Homo sapiens_hsa003100.61402801
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60840238
80Asthma_Homo sapiens_hsa053100.59073596
81Cysteine and methionine metabolism_Homo sapiens_hsa002700.58974045
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58962002
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58878359
84Chemical carcinogenesis_Homo sapiens_hsa052040.58789554
85Hematopoietic cell lineage_Homo sapiens_hsa046400.57232919
86Metabolic pathways_Homo sapiens_hsa011000.56977212
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.55253789
88Regulation of autophagy_Homo sapiens_hsa041400.54643845
89Olfactory transduction_Homo sapiens_hsa047400.54520012
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.54167890
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53107131
92Vitamin digestion and absorption_Homo sapiens_hsa049770.52697039
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51496497
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50662069
95B cell receptor signaling pathway_Homo sapiens_hsa046620.50630953
96Steroid biosynthesis_Homo sapiens_hsa001000.50524800
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50167991
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49895094
99Fat digestion and absorption_Homo sapiens_hsa049750.48508110
100Pentose phosphate pathway_Homo sapiens_hsa000300.48309495
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48262414
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.46035230
103Rheumatoid arthritis_Homo sapiens_hsa053230.45536280
104Prostate cancer_Homo sapiens_hsa052150.43221463
105Retinol metabolism_Homo sapiens_hsa008300.43187579
106MicroRNAs in cancer_Homo sapiens_hsa052060.42397573
107Chronic myeloid leukemia_Homo sapiens_hsa052200.42207293
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40782619
109Inositol phosphate metabolism_Homo sapiens_hsa005620.38296876
110Sulfur metabolism_Homo sapiens_hsa009200.38097265
111Influenza A_Homo sapiens_hsa051640.37459039
112Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37059956
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36526282
114Arachidonic acid metabolism_Homo sapiens_hsa005900.35975010
115Small cell lung cancer_Homo sapiens_hsa052220.35704675
116T cell receptor signaling pathway_Homo sapiens_hsa046600.34611731
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33590485
118Taste transduction_Homo sapiens_hsa047420.31263695
119Colorectal cancer_Homo sapiens_hsa052100.30908276
120Endometrial cancer_Homo sapiens_hsa052130.30857802
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30273329
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30248577
123Apoptosis_Homo sapiens_hsa042100.28231583
124Biosynthesis of amino acids_Homo sapiens_hsa012300.27128919
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26899854
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.26565352
127Basal cell carcinoma_Homo sapiens_hsa052170.26554038
128Circadian rhythm_Homo sapiens_hsa047100.26503649
129Phototransduction_Homo sapiens_hsa047440.25434180
130Non-small cell lung cancer_Homo sapiens_hsa052230.25100174
131mTOR signaling pathway_Homo sapiens_hsa041500.23861337
132Hepatitis B_Homo sapiens_hsa051610.23374945
133Hepatitis C_Homo sapiens_hsa051600.23360255
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22706308
135Folate biosynthesis_Homo sapiens_hsa007900.22655708
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22232286
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21294873
138FoxO signaling pathway_Homo sapiens_hsa040680.20384707
139Prolactin signaling pathway_Homo sapiens_hsa049170.20370522
140Cyanoamino acid metabolism_Homo sapiens_hsa004600.20332017
141Fructose and mannose metabolism_Homo sapiens_hsa000510.19887112
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.14264015
143Wnt signaling pathway_Homo sapiens_hsa043100.13566173
144Pathways in cancer_Homo sapiens_hsa052000.12587747
145Glycosaminoglycan degradation_Homo sapiens_hsa005310.11247912
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11211399
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07888020
148Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07781452

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