TTK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.72012288
2protein localization to kinetochore (GO:0034501)5.66989585
3kinetochore organization (GO:0051383)5.23952944
4mitotic chromosome condensation (GO:0007076)5.20548090
5mitotic sister chromatid segregation (GO:0000070)5.17641465
6metaphase plate congression (GO:0051310)5.14813765
7DNA ligation (GO:0006266)5.12600114
8protein localization to chromosome, centromeric region (GO:0071459)5.02837772
9sister chromatid segregation (GO:0000819)4.81216493
10attachment of spindle microtubules to kinetochore (GO:0008608)4.80217111
11DNA topological change (GO:0006265)4.80018899
12establishment of chromosome localization (GO:0051303)4.75078145
13CENP-A containing nucleosome assembly (GO:0034080)4.71592903
14chromatin remodeling at centromere (GO:0031055)4.70192444
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.63887792
16kinetochore assembly (GO:0051382)4.60350526
17meiotic chromosome segregation (GO:0045132)4.51521533
18nuclear pore organization (GO:0006999)4.42670326
19regulation of spindle organization (GO:0090224)4.40749598
20nuclear pore complex assembly (GO:0051292)4.37048428
21mitotic nuclear envelope disassembly (GO:0007077)4.35640060
22DNA replication initiation (GO:0006270)4.33103180
23DNA replication-independent nucleosome organization (GO:0034724)4.30566063
24DNA replication-independent nucleosome assembly (GO:0006336)4.30566063
25establishment of integrated proviral latency (GO:0075713)4.27111447
26DNA unwinding involved in DNA replication (GO:0006268)4.25722894
27DNA replication-dependent nucleosome organization (GO:0034723)4.24579422
28DNA replication-dependent nucleosome assembly (GO:0006335)4.24579422
29DNA strand elongation involved in DNA replication (GO:0006271)4.24460880
30DNA replication checkpoint (GO:0000076)4.16567447
31histone exchange (GO:0043486)4.13598513
32mitotic sister chromatid cohesion (GO:0007064)4.07275899
33nuclear envelope disassembly (GO:0051081)4.06185192
34membrane disassembly (GO:0030397)4.06185192
35DNA strand elongation (GO:0022616)4.05412332
36telomere maintenance via semi-conservative replication (GO:0032201)3.99059130
37regulation of mitotic spindle organization (GO:0060236)3.97952835
38protein localization to chromosome (GO:0034502)3.97041012
39positive regulation of chromosome segregation (GO:0051984)3.93065096
40mitotic G2/M transition checkpoint (GO:0044818)3.87684791
41mitotic recombination (GO:0006312)3.87321500
42chromosome segregation (GO:0007059)3.87146108
43regulation of sister chromatid cohesion (GO:0007063)3.86797434
44* spindle checkpoint (GO:0031577)3.85993456
45* regulation of chromosome segregation (GO:0051983)3.84037764
46telomere maintenance via recombination (GO:0000722)3.82848129
47regulation of centrosome cycle (GO:0046605)3.80089797
48regulation of centriole replication (GO:0046599)3.77745737
49positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77212148
50positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77212148
51positive regulation of mitotic sister chromatid separation (GO:1901970)3.77212148
52protein K6-linked ubiquitination (GO:0085020)3.72618564
53* negative regulation of chromosome segregation (GO:0051985)3.61382693
54* regulation of mitotic metaphase/anaphase transition (GO:0030071)3.60291251
55* negative regulation of mitotic sister chromatid separation (GO:2000816)3.57433418
56* negative regulation of mitotic sister chromatid segregation (GO:0033048)3.57433418
57* negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.57433418
58* negative regulation of sister chromatid segregation (GO:0033046)3.57433418
59* regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.56380099
60* spindle assembly checkpoint (GO:0071173)3.54794809
61* negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.52423669
62* mitotic spindle checkpoint (GO:0071174)3.50044507
63chromatin assembly or disassembly (GO:0006333)3.48640262
64telomere maintenance via telomere lengthening (GO:0010833)3.46977107
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.46023817
66* mitotic spindle assembly checkpoint (GO:0007094)3.45186302
67chromosome condensation (GO:0030261)3.44874292
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.44435191
69* regulation of sister chromatid segregation (GO:0033045)3.43918991
70* regulation of mitotic sister chromatid separation (GO:0010965)3.43918991
71* regulation of mitotic sister chromatid segregation (GO:0033047)3.43918991
72double-strand break repair via nonhomologous end joining (GO:0006303)3.43615638
73non-recombinational repair (GO:0000726)3.43615638
74regulation of double-strand break repair via homologous recombination (GO:0010569)3.41409173
75synapsis (GO:0007129)3.39695924
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.38006918
77regulation of mitotic spindle checkpoint (GO:1903504)3.38006918
78regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32852494
79pore complex assembly (GO:0046931)3.32815426
80regulation of DNA endoreduplication (GO:0032875)3.32471698
81mitotic G2 DNA damage checkpoint (GO:0007095)3.30436516
82microtubule depolymerization (GO:0007019)3.30340202
83resolution of meiotic recombination intermediates (GO:0000712)3.28390655
84mismatch repair (GO:0006298)3.28213364
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.26354930
86regulation of histone H3-K9 methylation (GO:0051570)3.25397090
87DNA geometric change (GO:0032392)3.25180012
88DNA duplex unwinding (GO:0032508)3.24240517
89DNA double-strand break processing (GO:0000729)3.23986510
90ATP-dependent chromatin remodeling (GO:0043044)3.23582494
91ventricular cardiac muscle cell development (GO:0055015)3.23418540
92somatic hypermutation of immunoglobulin genes (GO:0016446)3.20598219
93somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20598219
94negative regulation of DNA-dependent DNA replication (GO:2000104)3.17477172
95* negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.15948830
96DNA packaging (GO:0006323)3.15196700
97* negative regulation of nuclear division (GO:0051784)3.13854818
98regulation of spindle checkpoint (GO:0090231)3.13393466
99establishment of viral latency (GO:0019043)3.13028992
100regulation of telomere maintenance via telomerase (GO:0032210)3.12641701
101negative regulation of histone methylation (GO:0031061)3.12350013
102maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12288950
103nuclear envelope organization (GO:0006998)3.11872141
104* negative regulation of cell division (GO:0051782)3.10822104
105histone-serine phosphorylation (GO:0035404)3.10138192
106nucleobase biosynthetic process (GO:0046112)3.09825080
107DNA conformation change (GO:0071103)3.07754601
108folic acid-containing compound biosynthetic process (GO:0009396)3.06481436
109mitotic cell cycle (GO:0000278)3.05966595
110ribosome assembly (GO:0042255)3.01510755
111maturation of 5.8S rRNA (GO:0000460)2.98708443
112IMP biosynthetic process (GO:0006188)2.97788539
113regulation of centrosome duplication (GO:0010824)2.97397286
114chromosome organization (GO:0051276)2.94379088
115telomere maintenance (GO:0000723)2.91436460
116* negative regulation of mitosis (GO:0045839)2.91151362
117telomere organization (GO:0032200)2.89448060
118regulation of double-strand break repair (GO:2000779)2.88441850
119IMP metabolic process (GO:0046040)2.88411635
120purine nucleobase biosynthetic process (GO:0009113)2.86753354
121replication fork processing (GO:0031297)2.85354713
122regulation of exit from mitosis (GO:0007096)2.85082339

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.64047729
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.81134657
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.42047590
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.80796223
5AR_21909140_ChIP-Seq_LNCAP_Human2.96518183
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.91068927
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73966763
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69012112
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58128309
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52314306
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.50627419
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.46595517
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.46335773
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31023379
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29684327
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.27915504
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16484619
18* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12691573
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.11316934
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08677781
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.05878729
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.01997135
23E2F7_22180533_ChIP-Seq_HELA_Human10.7334092
24XRN2_22483619_ChIP-Seq_HELA_Human1.97360163
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97332451
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94992797
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93937590
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.91412958
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.86230318
30VDR_23849224_ChIP-Seq_CD4+_Human1.80544693
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71731562
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70628103
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.69807771
34FOXP3_21729870_ChIP-Seq_TREG_Human1.66087335
35DCP1A_22483619_ChIP-Seq_HELA_Human1.65611813
36TTF2_22483619_ChIP-Seq_HELA_Human1.64926804
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62148836
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57290574
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55619764
40GABP_19822575_ChIP-Seq_HepG2_Human1.50276518
41ELK1_19687146_ChIP-ChIP_HELA_Human1.44695715
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43339871
43CIITA_25753668_ChIP-Seq_RAJI_Human1.39670065
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37915300
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37527337
46KDM5A_27292631_Chip-Seq_BREAST_Human1.35945025
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34085380
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33570109
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.33185015
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32896080
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32183774
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28889675
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26623142
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23842527
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23649866
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22085755
57EWS_26573619_Chip-Seq_HEK293_Human1.21116018
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19317242
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19277609
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17877874
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17596096
62KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15784164
63MYC_22102868_ChIP-Seq_BL_Human1.15240415
64MYC_18940864_ChIP-ChIP_HL60_Human1.14108400
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12858924
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10947907
67ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10820676
68NANOG_21062744_ChIP-ChIP_HESCs_Human1.08019815
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05491984
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03151621
71SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00719983
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99392857
73* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99363410
74* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98339964
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97488650
76YY1_21170310_ChIP-Seq_MESCs_Mouse0.97306761
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95957883
78FUS_26573619_Chip-Seq_HEK293_Human0.92681857
79TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92031601
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91469448
81TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90268844
82KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90191088
83KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90191088
84KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90191088
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88754123
86TFEB_21752829_ChIP-Seq_HELA_Human0.87106949
87SRF_21415370_ChIP-Seq_HL-1_Mouse0.87092754
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86641887
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85246117
90* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85007892
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83379756
92* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.82604431
93* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81858618
94KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81847218
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.81019257
96CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80133952
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78609230
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.78196169
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77487670
100ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77150668
101CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76538156
102ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76430977
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75111817
104NANOG_16153702_ChIP-ChIP_HESCs_Human0.74161724
105GATA1_26923725_Chip-Seq_HPCs_Mouse0.72383600
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72191893
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.71903720
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70761894
109SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.68993166
110KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67655491
111IRF1_19129219_ChIP-ChIP_H3396_Human0.66755521
112TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65741621
113CHD1_26751641_Chip-Seq_LNCaP_Human0.65281747
114HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.65048055
115FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.62604958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38265873
2MP0010094_abnormal_chromosome_stability5.14045539
3MP0003111_abnormal_nucleus_morphology4.67505098
4MP0004957_abnormal_blastocyst_morpholog4.22426304
5MP0003077_abnormal_cell_cycle4.17315178
6MP0008057_abnormal_DNA_replication3.80876600
7MP0008058_abnormal_DNA_repair3.16553689
8MP0008877_abnormal_DNA_methylation2.92698638
9MP0003123_paternal_imprinting2.74211196
10MP0008932_abnormal_embryonic_tissue2.71387680
11MP0008007_abnormal_cellular_replicative2.71107610
12MP0003718_maternal_effect2.42575148
13MP0001730_embryonic_growth_arrest2.24218958
14MP0000350_abnormal_cell_proliferation2.21475270
15MP0003121_genomic_imprinting2.06186074
16MP0010307_abnormal_tumor_latency1.99404046
17MP0003786_premature_aging1.82968729
18MP0001672_abnormal_embryogenesis/_devel1.81744770
19MP0005380_embryogenesis_phenotype1.81744770
20MP0001697_abnormal_embryo_size1.78747144
21MP0010352_gastrointestinal_tract_polyps1.76992620
22MP0002085_abnormal_embryonic_tissue1.75111944
23MP0002210_abnormal_sex_determination1.71465653
24MP0002396_abnormal_hematopoietic_system1.68938225
25MP0010030_abnormal_orbit_morphology1.65100092
26MP0002084_abnormal_developmental_patter1.64429314
27MP0001929_abnormal_gametogenesis1.54679412
28MP0003984_embryonic_growth_retardation1.52766082
29MP0002088_abnormal_embryonic_growth/wei1.49066839
30MP0002102_abnormal_ear_morphology1.48081624
31MP0002080_prenatal_lethality1.46827398
32MP0006292_abnormal_olfactory_placode1.45830691
33MP0003890_abnormal_embryonic-extraembry1.43672952
34MP0002086_abnormal_extraembryonic_tissu1.43659348
35MP0000490_abnormal_crypts_of1.41106376
36MP0000653_abnormal_sex_gland1.40781113
37MP0001145_abnormal_male_reproductive1.39808716
38MP0001119_abnormal_female_reproductive1.38411823
39MP0004197_abnormal_fetal_growth/weight/1.38001012
40MP0003937_abnormal_limbs/digits/tail_de1.33538490
41MP0000313_abnormal_cell_death1.29913014
42MP0002019_abnormal_tumor_incidence1.28528710
43MP0003941_abnormal_skin_development1.28439834
44MP0005076_abnormal_cell_differentiation1.24165012
45MP0001293_anophthalmia1.24065068
46MP0003315_abnormal_perineum_morphology1.23391592
47MP0003567_abnormal_fetal_cardiomyocyte1.19482741
48MP0004808_abnormal_hematopoietic_stem1.16828119
49MP0002653_abnormal_ependyma_morphology1.16659194
50MP0003787_abnormal_imprinting1.13172162
51MP0000566_synostosis1.09559656
52MP0009053_abnormal_anal_canal1.08574810
53MP0002233_abnormal_nose_morphology1.06876456
54MP0003136_yellow_coat_color1.06323973
55MP0002249_abnormal_larynx_morphology1.01360641
56MP0003699_abnormal_female_reproductive0.99869586
57MP0008789_abnormal_olfactory_epithelium0.99462591
58MP0006035_abnormal_mitochondrial_morpho0.97931956
59MP0003119_abnormal_digestive_system0.96593658
60MP0004264_abnormal_extraembryonic_tissu0.95190802
61MP0001529_abnormal_vocalization0.92810032
62MP0005389_reproductive_system_phenotype0.89658507
63MP0001915_intracranial_hemorrhage0.89170797
64MP0002111_abnormal_tail_morphology0.88382659
65MP0003698_abnormal_male_reproductive0.86163179
66MP0009672_abnormal_birth_weight0.85982497
67MP0000358_abnormal_cell_content/0.85742194
68MP0003705_abnormal_hypodermis_morpholog0.85178461
69MP0006054_spinal_hemorrhage0.84073647
70MP0006072_abnormal_retinal_apoptosis0.82865969
71MP0002160_abnormal_reproductive_system0.82678390
72MP0002161_abnormal_fertility/fecundity0.81301953
73MP0001286_abnormal_eye_development0.79855110
74MP0000432_abnormal_head_morphology0.78649127
75MP0009697_abnormal_copulation0.78054214
76MP0005395_other_phenotype0.76125944
77MP0004133_heterotaxia0.75622876
78MP0001919_abnormal_reproductive_system0.74989438
79MP0000703_abnormal_thymus_morphology0.74768095
80MP0005394_taste/olfaction_phenotype0.73760965
81MP0005499_abnormal_olfactory_system0.73760965
82MP0000537_abnormal_urethra_morphology0.73715178
83MP0005397_hematopoietic_system_phenotyp0.72890180
84MP0001545_abnormal_hematopoietic_system0.72890180
85MP0002009_preneoplasia0.71939735
86MP0003755_abnormal_palate_morphology0.71924357
87MP0005384_cellular_phenotype0.71641495
88MP0000049_abnormal_middle_ear0.71211397
89MP0009703_decreased_birth_body0.70778461
90MP0005621_abnormal_cell_physiology0.69936310
91MP0003385_abnormal_body_wall0.69474706
92MP0005023_abnormal_wound_healing0.69378011
93MP0002092_abnormal_eye_morphology0.68836006
94MP0003935_abnormal_craniofacial_develop0.68323910
95MP0001346_abnormal_lacrimal_gland0.67759989
96MP0003566_abnormal_cell_adhesion0.67304567
97MP0002877_abnormal_melanocyte_morpholog0.66999705
98MP0000647_abnormal_sebaceous_gland0.66271108
99MP0002234_abnormal_pharynx_morphology0.65199939
100MP0002932_abnormal_joint_morphology0.64258586
101MP0001727_abnormal_embryo_implantation0.63823073
102MP0004185_abnormal_adipocyte_glucose0.63676035
103MP0003861_abnormal_nervous_system0.63668265
104MP0001177_atelectasis0.63077614
105MP0002938_white_spotting0.63048460
106MP0005391_vision/eye_phenotype0.62455491
107MP0003763_abnormal_thymus_physiology0.62300333
108MP0001849_ear_inflammation0.61991663
109MP0003806_abnormal_nucleotide_metabolis0.61900983
110MP0003221_abnormal_cardiomyocyte_apopto0.61801990
111MP0003115_abnormal_respiratory_system0.60420513
112MP0002925_abnormal_cardiovascular_devel0.59273611
113MP0005501_abnormal_skin_physiology0.58702892
114MP0002282_abnormal_trachea_morphology0.57946523
115MP0001299_abnormal_eye_distance/0.57783855
116MP0002114_abnormal_axial_skeleton0.57758250
117MP0000428_abnormal_craniofacial_morphol0.57732637
118MP0003936_abnormal_reproductive_system0.56651343
119MP0010234_abnormal_vibrissa_follicle0.55081349
120MP0005451_abnormal_body_composition0.55026219
121MP0000762_abnormal_tongue_morphology0.55003576
122MP0004233_abnormal_muscle_weight0.54754836
123MP0002398_abnormal_bone_marrow0.53836676
124MP0005408_hypopigmentation0.53424763
125MP0006036_abnormal_mitochondrial_physio0.53336514
126MP0003943_abnormal_hepatobiliary_system0.53256083
127MP0002697_abnormal_eye_size0.52451881

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)5.57961129
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.28501436
3Birth length less than 3rd percentile (HP:0003561)4.19056156
4Abnormality of chromosome stability (HP:0003220)3.98173523
5Meckel diverticulum (HP:0002245)3.70798506
6Abnormality of the preputium (HP:0100587)3.69075264
7Patellar aplasia (HP:0006443)3.56034048
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.54544549
9Abnormality of the ileum (HP:0001549)3.51693350
10Breast hypoplasia (HP:0003187)3.51159620
11Small intestinal stenosis (HP:0012848)3.35326783
12Duodenal stenosis (HP:0100867)3.35326783
13Abnormality of the labia minora (HP:0012880)3.34490546
14Medulloblastoma (HP:0002885)3.30116638
15Aplasia/Hypoplasia of the patella (HP:0006498)3.29829050
16Supernumerary spleens (HP:0009799)3.22156720
17Impulsivity (HP:0100710)3.20973999
18Reticulocytopenia (HP:0001896)3.20098504
19Absent radius (HP:0003974)3.18895392
20Ectopic kidney (HP:0000086)3.15571576
21Abnormal lung lobation (HP:0002101)3.15236290
22Myelodysplasia (HP:0002863)3.05029545
23Selective tooth agenesis (HP:0001592)3.01143551
24Aplasia involving forearm bones (HP:0009822)2.98071501
25Absent forearm bone (HP:0003953)2.98071501
26Nephroblastoma (Wilms tumor) (HP:0002667)2.96219887
27Sloping forehead (HP:0000340)2.93976281
28Colon cancer (HP:0003003)2.92192547
29Rhabdomyosarcoma (HP:0002859)2.82675056
30Increased nuchal translucency (HP:0010880)2.79668283
31Embryonal renal neoplasm (HP:0011794)2.79324575
32Ependymoma (HP:0002888)2.78592367
33Oral leukoplakia (HP:0002745)2.76963805
34Volvulus (HP:0002580)2.74886096
35Abnormality of the duodenum (HP:0002246)2.74033246
36Absent thumb (HP:0009777)2.64049109
37Carpal bone hypoplasia (HP:0001498)2.62290610
38Facial hemangioma (HP:0000329)2.60767468
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.60169613
40Embryonal neoplasm (HP:0002898)2.59477689
41Agnosia (HP:0010524)2.57437915
42Abnormality of the carotid arteries (HP:0005344)2.52142643
43Duplicated collecting system (HP:0000081)2.49760812
44Bone marrow hypocellularity (HP:0005528)2.41643660
45Aplasia/Hypoplasia of the sternum (HP:0006714)2.39747380
46Short thumb (HP:0009778)2.36826537
47Clubbing of toes (HP:0100760)2.33855293
48Degeneration of anterior horn cells (HP:0002398)2.31984118
49Abnormality of the anterior horn cell (HP:0006802)2.31984118
50Aplastic anemia (HP:0001915)2.30775869
51Cafe-au-lait spot (HP:0000957)2.29043854
52Abnormality of the renal collecting system (HP:0004742)2.27187284
53Triphalangeal thumb (HP:0001199)2.26897738
54Short 4th metacarpal (HP:0010044)2.26428261
55Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26428261
56Premature ovarian failure (HP:0008209)2.22847203
57Neoplasm of the oral cavity (HP:0100649)2.21324974
58Horseshoe kidney (HP:0000085)2.20945683
59Cortical dysplasia (HP:0002539)2.17715006
60Choanal atresia (HP:0000453)2.17574640
61Proximal placement of thumb (HP:0009623)2.16935616
62Tracheoesophageal fistula (HP:0002575)2.16163310
63Neoplasm of the pancreas (HP:0002894)2.16111088
64Deviation of the thumb (HP:0009603)2.15762166
65Neoplasm of striated muscle (HP:0009728)2.11241188
66Abnormality of DNA repair (HP:0003254)2.10191110
67Neoplasm of the colon (HP:0100273)2.08652423
6811 pairs of ribs (HP:0000878)2.08253136
69Atresia of the external auditory canal (HP:0000413)2.07497370
70Multiple enchondromatosis (HP:0005701)2.07441163
71Abnormal umbilical cord blood vessels (HP:0011403)2.07063917
72Single umbilical artery (HP:0001195)2.07063917
73Abnormality of the fetal cardiovascular system (HP:0010948)2.07063917
74Abnormal number of incisors (HP:0011064)2.05458061
75Shawl scrotum (HP:0000049)2.05013371
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04838149
77Rough bone trabeculation (HP:0100670)2.03151364
78Arteriovenous malformation (HP:0100026)2.03105243
79High pitched voice (HP:0001620)2.01950428
80Abdominal situs inversus (HP:0003363)1.98528001
81Abnormality of abdominal situs (HP:0011620)1.98528001
82Deep philtrum (HP:0002002)1.93644169
83Acute myeloid leukemia (HP:0004808)1.92834794
84Premature graying of hair (HP:0002216)1.92825245
85Hypoplastic pelvis (HP:0008839)1.92019227
86Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91224607
87Septo-optic dysplasia (HP:0100842)1.90941571
88Sandal gap (HP:0001852)1.90720240
89Biliary tract neoplasm (HP:0100574)1.90317389
90Prominent nose (HP:0000448)1.89971141
91Astrocytoma (HP:0009592)1.88777239
92Abnormality of the astrocytes (HP:0100707)1.88777239
93Oligodactyly (HP:0012165)1.88486344
94Abnormality of chromosome segregation (HP:0002916)1.87573623
95Abnormality of the septum pellucidum (HP:0007375)1.86970301
96Rib fusion (HP:0000902)1.86206721
97Duplication of thumb phalanx (HP:0009942)1.84373410
98Secondary amenorrhea (HP:0000869)1.82484134
99Abnormality of glycolysis (HP:0004366)1.81853750
100Basal cell carcinoma (HP:0002671)1.81457915
101Breast aplasia (HP:0100783)1.79815464
102Increased serum pyruvate (HP:0003542)1.79747924
103Aplasia/hypoplasia of the humerus (HP:0006507)1.79661373
104Ovarian neoplasm (HP:0100615)1.78862727
105Squamous cell carcinoma (HP:0002860)1.78700618
106Aplasia/Hypoplasia of the breasts (HP:0010311)1.77902657
107Leiomyosarcoma (HP:0100243)1.77701511
108Uterine leiomyosarcoma (HP:0002891)1.77701511
109Oligodactyly (hands) (HP:0001180)1.77468559
110Absent septum pellucidum (HP:0001331)1.76474121
111Glioma (HP:0009733)1.75864862
112Overlapping toe (HP:0001845)1.75829654
113Missing ribs (HP:0000921)1.75221701
114Malignant gastrointestinal tract tumors (HP:0006749)1.74660171
115Gastrointestinal carcinoma (HP:0002672)1.74660171
116Microvesicular hepatic steatosis (HP:0001414)1.73704782
117Blepharitis (HP:0000498)1.73032409
118Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72653250
119Abnormality of the umbilical cord (HP:0010881)1.72253270
120Capillary hemangiomas (HP:0005306)1.71842052
121Intestinal polyposis (HP:0200008)1.70716206
122Uterine neoplasm (HP:0010784)1.70450838
123Cellular immunodeficiency (HP:0005374)1.69738467
124Pancreatic islet-cell hyperplasia (HP:0004510)1.66778475
125Progressive external ophthalmoplegia (HP:0000590)1.64232251
126Short middle phalanx of the 5th finger (HP:0004220)1.63769033
127Facial cleft (HP:0002006)1.63653043
128Intestinal polyp (HP:0005266)1.63432113
129Abnormality of cochlea (HP:0000375)1.63312406
130Bifid tongue (HP:0010297)1.60560864
131Irregular epiphyses (HP:0010582)1.57861552
132High anterior hairline (HP:0009890)1.56618283
133Abnormality of methionine metabolism (HP:0010901)1.56434676
134Abnormal auditory evoked potentials (HP:0006958)1.54499162
135Combined immunodeficiency (HP:0005387)1.51187961
136Abnormality of the pons (HP:0007361)1.50668203

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.04204185
2BUB14.52858590
3WEE13.92590307
4NEK23.69135623
5PLK43.27552745
6* TTK3.05096685
7PLK12.56819476
8SRPK12.45426294
9NEK12.40051711
10CDK122.39918433
11EIF2AK12.35273043
12BRSK22.25953231
13EEF2K2.20049063
14AURKB2.06785588
15ACVR1B2.03839455
16PLK31.93612833
17ATR1.90760912
18STK101.83001216
19RPS6KB21.73369265
20* CHEK21.72927242
21CDK71.69905616
22MAP3K81.64034364
23VRK11.59913248
24MKNK11.59224791
25BRSK11.51752219
26TRIM281.50927622
27MELK1.50586396
28CHEK11.48616777
29AURKA1.45609568
30LATS11.44165687
31PASK1.44071916
32CDK41.42975189
33VRK21.42332295
34STK41.41716892
35STK31.38826016
36STK38L1.38291545
37TAF11.33476821
38MST41.32457180
39TSSK61.31463721
40CCNB11.27824363
41RPS6KA41.26895287
42ATM1.23699822
43TLK11.19517935
44MKNK21.16132268
45DYRK31.13768041
46MAP3K61.12037897
47CDK81.06933364
48ZAK1.02694979
49EPHA21.02347524
50MAPKAPK31.01703046
51LATS20.98334868
52BRD40.97496144
53TNIK0.96619659
54EIF2AK30.95354537
55* CDK20.93914468
56CDK60.91038815
57CDK10.85115440
58WNK30.84182462
59PAK40.78119221
60TGFBR10.77329702
61ERBB40.75029982
62TESK20.74322592
63ERBB30.72426729
64EIF2AK20.68442843
65PIM10.68141259
66PBK0.65982016
67SCYL20.63947647
68STK160.63280372
69BMPR1B0.61858224
70CDK90.56937146
71BCR0.54877550
72CSNK2A10.53721755
73PAK10.52886888
74CSNK2A20.50789920
75PLK20.49100242
76NME10.47263966
77MAP3K100.46657537
78RAF10.45987981
79NME20.45706461
80PDK40.45105427
81PDK30.45105427
82PRKCI0.43910848
83NEK90.43721850
84FGFR10.43477990
85CLK10.43038530
86MET0.41980658
87CSNK1D0.40922014
88SMG10.40578931
89CDK180.39775718
90PRKDC0.39548459
91FLT30.38940603
92MTOR0.37192642
93RPS6KA50.36433653
94CDK150.36402461
95CDK11A0.35395575
96NEK60.33342657
97MAPK140.32808722
98AKT30.32610820
99ALK0.32584852
100CSNK1E0.32213234
101AKT10.31794495
102MST1R0.31028717
103CDK140.30624777
104TRPM70.29012229
105PDK20.28359421
106AKT20.26574168
107CSNK1G10.26305857
108KSR10.25772078
109NUAK10.25555732
110MAP3K50.24525835
111GSK3B0.24326023
112STK240.23806400
113DYRK20.23349679
114UHMK10.22827268
115MARK30.21553374
116PNCK0.21543136
117* MAPK10.21033458
118YES10.20948725
119LRRK20.19796517
120MAPK110.18975440
121CDK30.17860776
122MUSK0.17666260
123RPS6KB10.16333641
124STK390.15216207

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.90707566
2Mismatch repair_Homo sapiens_hsa034304.56556452
3Homologous recombination_Homo sapiens_hsa034403.59953037
4* Cell cycle_Homo sapiens_hsa041103.59324711
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40853479
6Base excision repair_Homo sapiens_hsa034103.26174696
7RNA transport_Homo sapiens_hsa030133.21390532
8Fanconi anemia pathway_Homo sapiens_hsa034603.07020147
9Spliceosome_Homo sapiens_hsa030403.02029981
10Nucleotide excision repair_Homo sapiens_hsa034203.00727621
11One carbon pool by folate_Homo sapiens_hsa006702.58052195
12RNA polymerase_Homo sapiens_hsa030202.57936468
13Non-homologous end-joining_Homo sapiens_hsa034502.55721337
14RNA degradation_Homo sapiens_hsa030182.45903018
15Basal transcription factors_Homo sapiens_hsa030222.44014859
16Pyrimidine metabolism_Homo sapiens_hsa002402.10525585
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09082812
18p53 signaling pathway_Homo sapiens_hsa041152.05086206
19Ribosome_Homo sapiens_hsa030102.02100196
20mRNA surveillance pathway_Homo sapiens_hsa030151.97914953
21Proteasome_Homo sapiens_hsa030501.91849418
22Oocyte meiosis_Homo sapiens_hsa041141.55943530
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48533022
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46964319
25Systemic lupus erythematosus_Homo sapiens_hsa053221.46361157
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45992773
27Pyruvate metabolism_Homo sapiens_hsa006201.33187077
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31645819
29Steroid biosynthesis_Homo sapiens_hsa001001.27762646
30Protein export_Homo sapiens_hsa030601.24255119
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18537205
32Purine metabolism_Homo sapiens_hsa002301.14866795
33Propanoate metabolism_Homo sapiens_hsa006401.11178039
34Epstein-Barr virus infection_Homo sapiens_hsa051691.10003779
35Viral carcinogenesis_Homo sapiens_hsa052031.08911927
36MicroRNAs in cancer_Homo sapiens_hsa052061.08629992
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07352537
38Herpes simplex infection_Homo sapiens_hsa051681.02121250
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93087368
40Carbon metabolism_Homo sapiens_hsa012000.92885777
41HTLV-I infection_Homo sapiens_hsa051660.92077800
42Vitamin B6 metabolism_Homo sapiens_hsa007500.91202471
43TGF-beta signaling pathway_Homo sapiens_hsa043500.89709148
44Small cell lung cancer_Homo sapiens_hsa052220.78689558
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78577199
46Hippo signaling pathway_Homo sapiens_hsa043900.76101234
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74769967
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73927275
49Basal cell carcinoma_Homo sapiens_hsa052170.72635991
50Thyroid cancer_Homo sapiens_hsa052160.71273021
51Fatty acid elongation_Homo sapiens_hsa000620.70216731
52Selenocompound metabolism_Homo sapiens_hsa004500.70062704
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69816696
54Colorectal cancer_Homo sapiens_hsa052100.68282566
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67576410
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.67406905
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.65573717
58Huntingtons disease_Homo sapiens_hsa050160.64414935
59Antigen processing and presentation_Homo sapiens_hsa046120.62263897
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61685529
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59751257
62Adherens junction_Homo sapiens_hsa045200.58922603
63Alcoholism_Homo sapiens_hsa050340.55783272
64Notch signaling pathway_Homo sapiens_hsa043300.54617760
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52767575
66Parkinsons disease_Homo sapiens_hsa050120.52405298
67Biosynthesis of amino acids_Homo sapiens_hsa012300.50851788
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49819238
69Hedgehog signaling pathway_Homo sapiens_hsa043400.48350346
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46332953
71Linoleic acid metabolism_Homo sapiens_hsa005910.46132158
72Pancreatic cancer_Homo sapiens_hsa052120.45818290
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42656122
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41374071
75Hepatitis B_Homo sapiens_hsa051610.41231774
76Pentose phosphate pathway_Homo sapiens_hsa000300.39387098
77Apoptosis_Homo sapiens_hsa042100.39169527
78Chronic myeloid leukemia_Homo sapiens_hsa052200.38599748
79Pathways in cancer_Homo sapiens_hsa052000.37289056
80Bladder cancer_Homo sapiens_hsa052190.36775950
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36727405
82Folate biosynthesis_Homo sapiens_hsa007900.35985413
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.33720438
84Legionellosis_Homo sapiens_hsa051340.33697898
85Prostate cancer_Homo sapiens_hsa052150.32434393
86Metabolic pathways_Homo sapiens_hsa011000.31897101
87Wnt signaling pathway_Homo sapiens_hsa043100.31065912
88Lysine degradation_Homo sapiens_hsa003100.31047145
89Glutathione metabolism_Homo sapiens_hsa004800.29665469
90FoxO signaling pathway_Homo sapiens_hsa040680.29186302
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28025938
92Oxidative phosphorylation_Homo sapiens_hsa001900.27646235
93Fatty acid metabolism_Homo sapiens_hsa012120.27475562
94Influenza A_Homo sapiens_hsa051640.27291817
95Arachidonic acid metabolism_Homo sapiens_hsa005900.26291360
96Sulfur relay system_Homo sapiens_hsa041220.26064993
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.24327537
98mTOR signaling pathway_Homo sapiens_hsa041500.23560368
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.23537482
100Melanoma_Homo sapiens_hsa052180.23452920
101Shigellosis_Homo sapiens_hsa051310.23217363
102Non-small cell lung cancer_Homo sapiens_hsa052230.22828999
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22791597
104Arginine and proline metabolism_Homo sapiens_hsa003300.21976176
105Endometrial cancer_Homo sapiens_hsa052130.21495900
106Measles_Homo sapiens_hsa051620.20457507
107Ovarian steroidogenesis_Homo sapiens_hsa049130.19656175
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.19256881
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18723988
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18466237
111Tight junction_Homo sapiens_hsa045300.18305653
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.18184897
113HIF-1 signaling pathway_Homo sapiens_hsa040660.17749332
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.17239665
115Viral myocarditis_Homo sapiens_hsa054160.16866172
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16360961
117Primary immunodeficiency_Homo sapiens_hsa053400.13819036
118Hematopoietic cell lineage_Homo sapiens_hsa046400.12620213
119Proteoglycans in cancer_Homo sapiens_hsa052050.11337428
120Alzheimers disease_Homo sapiens_hsa050100.11001724
121N-Glycan biosynthesis_Homo sapiens_hsa005100.10655651
122Ether lipid metabolism_Homo sapiens_hsa005650.10280046
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09762928
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.09341573
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.09195271
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08922832
127Circadian rhythm_Homo sapiens_hsa047100.07388166
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.06139780
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.04310089
130Vitamin digestion and absorption_Homo sapiens_hsa049770.03433463
131Gap junction_Homo sapiens_hsa045400.02285595

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