TTL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spindle assembly involved in mitosis (GO:0090307)9.81528278
2response to lipoprotein particle (GO:0055094)9.11759752
3positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)7.99752669
4negative regulation of telomerase activity (GO:0051974)7.92391004
5positive regulation of inositol phosphate biosynthetic process (GO:0060732)7.85566901
6microtubule cytoskeleton organization involved in mitosis (GO:1902850)7.62445274
7centrosome duplication (GO:0051298)7.08395109
8anterior/posterior axis specification, embryo (GO:0008595)6.94684311
9inner cell mass cell proliferation (GO:0001833)6.76158903
10regulation of tight junction assembly (GO:2000810)6.58355440
11cell differentiation involved in embryonic placenta development (GO:0060706)6.53797817
12prostate gland growth (GO:0060736)6.34567098
13myelination in peripheral nervous system (GO:0022011)6.34364073
14peripheral nervous system axon ensheathment (GO:0032292)6.34364073
15mitochondrial fusion (GO:0008053)6.08044322
16regulation of syncytium formation by plasma membrane fusion (GO:0060142)6.01933345
17positive regulation of oligodendrocyte differentiation (GO:0048714)5.97962949
18mitochondrion morphogenesis (GO:0070584)5.96728544
19regulation of inositol phosphate biosynthetic process (GO:0010919)5.89327350
20negative regulation of Rho protein signal transduction (GO:0035024)5.78430158
21regulation of cell proliferation involved in kidney development (GO:1901722)5.78144947
22positive regulation of fatty acid oxidation (GO:0046321)5.72028921
23synaptic vesicle maturation (GO:0016188)5.65110733
24white fat cell differentiation (GO:0050872)5.61900469
25cellular response to lithium ion (GO:0071285)5.56307101
26regulation of telomerase activity (GO:0051972)5.54141327
27regulation of energy homeostasis (GO:2000505)5.51532277
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.37663591
29lung-associated mesenchyme development (GO:0060484)5.36392920
30regulation of sequestering of triglyceride (GO:0010889)5.36316678
31gland morphogenesis (GO:0022612)5.32367639
32regulation of short-term neuronal synaptic plasticity (GO:0048172)5.30466493
33response to caffeine (GO:0031000)5.14223544
34positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06009358
35negative regulation of acute inflammatory response (GO:0002674)5.00392996
36glutamate secretion (GO:0014047)4.95962749
37serine family amino acid catabolic process (GO:0009071)4.95623923
38locomotory exploration behavior (GO:0035641)4.91441541
39synaptic vesicle exocytosis (GO:0016079)4.91229918
40synapsis (GO:0007129)4.90938981
41positive regulation of mitochondrial calcium ion concentration (GO:0051561)4.87218591
42layer formation in cerebral cortex (GO:0021819)4.82398727
43positive regulation of mitochondrial fission (GO:0090141)4.72671788
44cell migration in hindbrain (GO:0021535)4.69306319
45regulation of synaptic vesicle exocytosis (GO:2000300)4.66729661
46embryonic camera-type eye development (GO:0031076)4.66493729
47proline transport (GO:0015824)4.64822515
48regulation of cholesterol storage (GO:0010885)4.62466990
49negative regulation of DNA biosynthetic process (GO:2000279)4.60522288
50lipoprotein transport (GO:0042953)4.57894479
51mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.51015935
52vocalization behavior (GO:0071625)4.48919095
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.48143132
54mitochondrial respiratory chain complex I assembly (GO:0032981)4.48143132
55NADH dehydrogenase complex assembly (GO:0010257)4.48143132
56protein kinase C signaling (GO:0070528)4.46410205
57DNA deamination (GO:0045006)4.43071728
58negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.36614854
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.35421651
60regulation of synapse structural plasticity (GO:0051823)4.34710300
61synaptic vesicle docking involved in exocytosis (GO:0016081)4.33623724
62neuronal action potential propagation (GO:0019227)4.29908894
63regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.29127603
64negative regulation of kidney development (GO:0090185)4.26740774
65protein localization to synapse (GO:0035418)4.22011470
66glycine metabolic process (GO:0006544)4.10759561
67exploration behavior (GO:0035640)4.09254895
68ventricular septum development (GO:0003281)4.08050776
69regulation of synaptic vesicle transport (GO:1902803)4.07933259
70regulation of glutamate receptor signaling pathway (GO:1900449)4.01161459
71neuron cell-cell adhesion (GO:0007158)3.96145057
72TOR signaling (GO:0031929)3.93095250
73neurotransmitter secretion (GO:0007269)3.91033180
74peroxisome fission (GO:0016559)3.90815651
75negative regulation of microtubule polymerization (GO:0031115)3.88269742
76activation of protein kinase A activity (GO:0034199)3.86527255
77T cell lineage commitment (GO:0002360)3.78677594
78somite development (GO:0061053)3.77460068
79spinal cord development (GO:0021510)3.76186758
80monocyte differentiation (GO:0030224)3.75847313
81response to vitamin A (GO:0033189)3.70926570
82regulation of neuronal synaptic plasticity (GO:0048168)3.69078563
83neurofilament cytoskeleton organization (GO:0060052)3.68802278
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67987390
85regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.66647215
86negative regulation of dendrite morphogenesis (GO:0050774)3.66142210
87flavonoid metabolic process (GO:0009812)3.64014130
88cell communication by electrical coupling (GO:0010644)3.63181026
89dendritic spine morphogenesis (GO:0060997)3.61220797
90organ growth (GO:0035265)3.60747063
91mitochondrion transport along microtubule (GO:0047497)3.60167178
92establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.60167178
93cell proliferation in forebrain (GO:0021846)3.59153997
94detection of temperature stimulus involved in sensory perception (GO:0050961)3.58173494
95detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.58173494
96membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57211815
97membrane depolarization during action potential (GO:0086010)3.53991381
98regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53540087
99CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.53365029
100dendrite morphogenesis (GO:0048813)3.53046248
101negative regulation of lipid storage (GO:0010888)3.52525854
102regulation of mitochondrial fission (GO:0090140)3.52133010
103positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51451700
104neuromuscular process controlling balance (GO:0050885)3.50684602
105detection of temperature stimulus (GO:0016048)3.48107694
106negative regulation of TOR signaling (GO:0032007)3.47492829
107mitotic spindle organization (GO:0007052)3.45540865
108spindle assembly (GO:0051225)3.44244591
109lateral sprouting from an epithelium (GO:0060601)3.43198299
110axon cargo transport (GO:0008088)3.42554810
111purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.41231919
1123-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.41231919
113organelle transport along microtubule (GO:0072384)3.40227158
114cell communication involved in cardiac conduction (GO:0086065)3.38754451
115neuron recognition (GO:0008038)3.38152667
116establishment of mitochondrion localization (GO:0051654)3.36370045
117regulation of receptor biosynthetic process (GO:0010869)3.35491444
118positive regulation of synapse maturation (GO:0090129)3.34103669
119negative regulation of mast cell activation (GO:0033004)3.33439243
120axonal fasciculation (GO:0007413)3.33383703
121peristalsis (GO:0030432)3.32575180
122cellular potassium ion homeostasis (GO:0030007)3.32569423
123positive regulation of gliogenesis (GO:0014015)3.28950677
124vesicle transport along microtubule (GO:0047496)3.28166450
125regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.28122161
126sodium ion export (GO:0071436)3.26719775
127presynaptic membrane assembly (GO:0097105)3.26419006
128positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.24847569
129negative regulation of dendrite development (GO:2000171)3.23501394
130positive regulation of synaptic transmission, GABAergic (GO:0032230)3.22433123
131apoptotic process involved in morphogenesis (GO:0060561)3.21350980
132neurotransmitter-gated ion channel clustering (GO:0072578)3.20595506
133regulation of receptor binding (GO:1900120)3.19724119
134pyrimidine nucleobase catabolic process (GO:0006208)3.19211428
135regulation of collateral sprouting (GO:0048670)3.18645069
136response to methylmercury (GO:0051597)3.18386696
137plasma membrane repair (GO:0001778)3.15158401
138ionotropic glutamate receptor signaling pathway (GO:0035235)3.14232930
139regulation of transcription involved in cell fate commitment (GO:0060850)3.14098922
140gamma-aminobutyric acid transport (GO:0015812)3.12321550
141lymphangiogenesis (GO:0001946)3.11550631
142positive regulation of glomerulus development (GO:0090193)3.11520769
143T cell differentiation in thymus (GO:0033077)3.11500416
144sulfation (GO:0051923)3.11189906
145cardiac septum development (GO:0003279)3.10470038
146axon extension (GO:0048675)3.09368618
147regulation of fatty acid oxidation (GO:0046320)3.07789333
148regulation of dendritic spine morphogenesis (GO:0061001)3.05270699
149response to lithium ion (GO:0010226)3.04857045
150positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.04730344
151synaptic transmission, glutamatergic (GO:0035249)3.03901532
152positive regulation of axon extension (GO:0045773)3.03873223
153apoptotic process involved in development (GO:1902742)3.03809231
154neurotransmitter transport (GO:0006836)3.03668554
155neuronal action potential (GO:0019228)3.02340868
156innervation (GO:0060384)3.02284811
157regulation of neurotransmitter secretion (GO:0046928)3.01713048
158negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.00884713
159regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.00272726
160dopamine receptor signaling pathway (GO:0007212)3.00140996
161glycerol ether metabolic process (GO:0006662)2.99301371
162positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.99224838
163regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98882567
164regulation of glial cell proliferation (GO:0060251)2.98539146
165positive regulation of potassium ion transmembrane transport (GO:1901381)2.97716186
166cerebellar Purkinje cell differentiation (GO:0021702)2.96617951
167neuron-neuron synaptic transmission (GO:0007270)2.96307929
168chromosome organization involved in meiosis (GO:0070192)2.96022944
169negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.95242331
170regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94364733
171regulation of synaptic plasticity (GO:0048167)2.93496009
172response to auditory stimulus (GO:0010996)2.91583342
173neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.91203528
174positive regulation of alcohol biosynthetic process (GO:1902932)2.90999524
175alanine transport (GO:0032328)2.90834452
176negative regulation of nitric-oxide synthase activity (GO:0051001)2.90765500
177glutamate receptor signaling pathway (GO:0007215)2.90658123
178neuromuscular process (GO:0050905)2.89355359
179calcium-mediated signaling using intracellular calcium source (GO:0035584)2.88941417
180prepulse inhibition (GO:0060134)2.87907468
181regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.87808686
182labyrinthine layer blood vessel development (GO:0060716)2.86554867
183regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86494224
184adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86475248
185neuromuscular process controlling posture (GO:0050884)2.86062978
186postsynaptic membrane organization (GO:0001941)2.85964644
187G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84917217
188neuron projection extension (GO:1990138)2.84665085
189protein complex biogenesis (GO:0070271)2.84647973
190membrane depolarization (GO:0051899)2.84065647
191regulation of cAMP-dependent protein kinase activity (GO:2000479)2.83813303
192positive regulation of membrane potential (GO:0045838)2.83559442
193regulation of vesicle fusion (GO:0031338)2.83035193
194regulation of postsynaptic membrane potential (GO:0060078)2.81891949
195membrane repolarization (GO:0086009)2.80738038
196long-term memory (GO:0007616)2.80136183
197regulation of neurotransmitter levels (GO:0001505)2.80110467
198lung morphogenesis (GO:0060425)2.79625089
199branching involved in labyrinthine layer morphogenesis (GO:0060670)15.1965648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10588500
2E2F7_22180533_ChIP-Seq_HELA_Human5.04203762
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10064699
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00463887
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95619926
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.88454916
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83851125
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83851125
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73504638
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.67770823
11GBX2_23144817_ChIP-Seq_PC3_Human2.64767591
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.56759630
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56353122
14LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.53790424
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51684602
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.49913377
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49253115
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48655270
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43754032
20TDRD3_21172665_ChIP-Seq_MCF-7_Human2.33495362
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32131753
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29458913
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29384547
24DROSHA_22980978_ChIP-Seq_HELA_Human2.24104779
25FUS_26573619_Chip-Seq_HEK293_Human2.21082420
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.18958312
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.18925856
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.17789151
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12944681
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05376629
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.01128014
32STAT6_21828071_ChIP-Seq_BEAS2B_Human10.2891805
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97188959
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92725253
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.86537984
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84763212
37AR_21572438_ChIP-Seq_LNCaP_Human1.83159960
38ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.77826451
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67946662
40CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66599169
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62632123
42MYC_18940864_ChIP-ChIP_HL60_Human1.61807729
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.60905711
44KDM2B_26808549_Chip-Seq_K562_Human1.58858537
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.58274506
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55358936
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54180136
48ZNF274_21170338_ChIP-Seq_K562_Hela1.50642933
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.50577822
50* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49147881
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49082491
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48534289
53ER_23166858_ChIP-Seq_MCF-7_Human1.46239521
54SMAD4_21799915_ChIP-Seq_A2780_Human1.44660015
55RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42583993
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.39758298
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.34925720
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34457023
59* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33853360
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.33303579
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32931650
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32499240
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32212383
64STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.32103010
65TBX3_20139965_ChIP-Seq_MESCs_Mouse1.31927953
66FOXM1_23109430_ChIP-Seq_U2OS_Human1.31579641
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31296697
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31081226
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30116592
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29777796
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.29476972
72ZNF263_19887448_ChIP-Seq_K562_Human1.28501832
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27870953
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27779284
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26549908
76TP53_18474530_ChIP-ChIP_U2OS_Human1.25295189
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23896596
78TAF15_26573619_Chip-Seq_HEK293_Human1.22326038
79IGF1R_20145208_ChIP-Seq_DFB_Human1.22165236
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21471056
81AR_19668381_ChIP-Seq_PC3_Human1.20340445
82TET1_21490601_ChIP-Seq_MESCs_Mouse1.18096450
83IRF1_19129219_ChIP-ChIP_H3396_Human1.17550174
84AHR_22903824_ChIP-Seq_MCF-7_Human1.16206655
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14147247
86SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13700967
87* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12553066
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11360959
89TCF4_23295773_ChIP-Seq_U87_Human1.11159302
90AR_25329375_ChIP-Seq_VCAP_Human1.10484251
91PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09785922
92CTCF_27219007_Chip-Seq_Bcells_Human1.09219325
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08279051
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07617847
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.06838270
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06695254
97SMAD_19615063_ChIP-ChIP_OVARY_Human1.06671278
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.05758334
99P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04532721
100STAT3_23295773_ChIP-Seq_U87_Human1.04446484
101BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04022375
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03926428
103ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03611468
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03196109
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.02171677
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.02165451
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.02148878
108TP53_20018659_ChIP-ChIP_R1E_Mouse1.01026159
109SMAD3_21741376_ChIP-Seq_ESCs_Human1.00734883
110SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.00175048
111ARNT_22903824_ChIP-Seq_MCF-7_Human1.00081047
112BCAT_22108803_ChIP-Seq_LS180_Human0.99811260
113TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99518769
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99194213
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99147872
116FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98953031
117OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98723905
118ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98658224
119MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.98505583
120RXR_22108803_ChIP-Seq_LS180_Human0.95728719
121RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95516096
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.95335100
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95064249
124TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95036838
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94150420
126P300_19829295_ChIP-Seq_ESCs_Human0.93789381
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93738967
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93352186
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93316401
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93099352
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92553505
132MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.91912189
133KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91367393
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.91346247
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91131672
136SOX9_26525672_Chip-Seq_HEART_Mouse0.90184918
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89624560
138CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89514797
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88428454
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87814325
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.87778881
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87530833
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87488485
144RNF2_27304074_Chip-Seq_NSC_Mouse0.87218346
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.86846430
146CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86843802
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86030458
148GATA1_26923725_Chip-Seq_HPCs_Mouse0.85716257
149SMAD3_21741376_ChIP-Seq_HESCs_Human0.84697816
150KLF4_19829295_ChIP-Seq_ESCs_Human0.84631615
151MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84138606
152NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84094932
153CBX2_27304074_Chip-Seq_ESCs_Mouse0.83686274
154SMAD4_21741376_ChIP-Seq_EPCs_Human0.81726384
155NANOG_18692474_ChIP-Seq_MESCs_Mouse0.81448133
156* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81179375
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.81034937
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80601669
159NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79649602
160SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.79527474
161* NANOG_18555785_Chip-Seq_ESCs_Mouse0.76190810
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75514651

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose7.60972109
2MP0004859_abnormal_synaptic_plasticity5.73718735
3MP0000516_abnormal_urinary_system4.50242032
4MP0005367_renal/urinary_system_phenotyp4.50242032
5MP0004270_analgesia4.37232214
6MP0003315_abnormal_perineum_morphology4.25614170
7MP0002653_abnormal_ependyma_morphology4.10500889
8MP0001849_ear_inflammation3.99600576
9MP0002735_abnormal_chemical_nociception3.89126550
10MP0001968_abnormal_touch/_nociception3.86917212
11MP0004185_abnormal_adipocyte_glucose3.69938620
12MP0003693_abnormal_embryo_hatching3.62537974
13MP0003635_abnormal_synaptic_transmissio3.56835211
14MP0003724_increased_susceptibility_to3.52755631
15MP0009053_abnormal_anal_canal3.52399362
16MP0001485_abnormal_pinna_reflex3.51190251
17MP0001661_extended_life_span3.50897742
18MP0003880_abnormal_central_pattern3.48998613
19MP0004858_abnormal_nervous_system3.47186340
20MP0002734_abnormal_mechanical_nocicepti3.24523061
21MP0002736_abnormal_nociception_after3.12778591
22MP0002733_abnormal_thermal_nociception2.91635818
23MP0002063_abnormal_learning/memory/cond2.90881368
24MP0000049_abnormal_middle_ear2.63641525
25MP0009745_abnormal_behavioral_response2.63057708
26MP0005076_abnormal_cell_differentiation2.55497096
27MP0001970_abnormal_pain_threshold2.53781750
28MP0009046_muscle_twitch2.51550752
29MP0002064_seizures2.46289048
30MP0002822_catalepsy2.45130732
31MP0003119_abnormal_digestive_system2.37717002
32MP0006276_abnormal_autonomic_nervous2.36044108
33MP0002572_abnormal_emotion/affect_behav2.26241437
34MP0002272_abnormal_nervous_system2.19222853
35MP0005423_abnormal_somatic_nervous2.18326821
36MP0002184_abnormal_innervation2.13689885
37MP0002160_abnormal_reproductive_system2.11881092
38MP0003329_amyloid_beta_deposits2.09390241
39MP0000778_abnormal_nervous_system2.01588730
40MP0000537_abnormal_urethra_morphology2.00896944
41MP0004811_abnormal_neuron_physiology2.00391382
42MP0003937_abnormal_limbs/digits/tail_de1.97681094
43MP0001440_abnormal_grooming_behavior1.94498828
44MP0001486_abnormal_startle_reflex1.88190805
45MP0002067_abnormal_sensory_capabilities1.86256908
46MP0003890_abnormal_embryonic-extraembry1.85768139
47MP0009780_abnormal_chondrocyte_physiolo1.85634090
48MP0002282_abnormal_trachea_morphology1.85375844
49MP0000955_abnormal_spinal_cord1.79741397
50MP0002909_abnormal_adrenal_gland1.77376568
51MP0000003_abnormal_adipose_tissue1.76598809
52MP0009765_abnormal_xenobiotic_induced1.73866141
53MP0000751_myopathy1.69962882
54MP0009384_cardiac_valve_regurgitation1.68977251
55MP0005386_behavior/neurological_phenoty1.59799830
56MP0004924_abnormal_behavior1.59799830
57MP0002837_dystrophic_cardiac_calcinosis1.59643608
58MP0003172_abnormal_lysosome_physiology1.54975434
59MP0008569_lethality_at_weaning1.54179527
60MP0002138_abnormal_hepatobiliary_system1.49184224
61MP0002557_abnormal_social/conspecific_i1.45602001
62MP0001501_abnormal_sleep_pattern1.41365025
63MP0010094_abnormal_chromosome_stability1.38632317
64* MP0002882_abnormal_neuron_morphology1.37182306
65MP0001984_abnormal_olfaction1.33792427
66MP0003656_abnormal_erythrocyte_physiolo1.32221899
67MP0003936_abnormal_reproductive_system1.30313935
68* MP0002066_abnormal_motor_capabilities/c1.29200134
69MP0006292_abnormal_olfactory_placode1.27552784
70MP0003633_abnormal_nervous_system1.22603964
71MP0001348_abnormal_lacrimal_gland1.20838271
72MP0005623_abnormal_meninges_morphology1.19978424
73MP0003879_abnormal_hair_cell1.19290541
74MP0002102_abnormal_ear_morphology1.12717027
75MP0000015_abnormal_ear_pigmentation1.12180393
76MP0000569_abnormal_digit_pigmentation1.12164390
77MP0001697_abnormal_embryo_size1.11091371
78MP0004145_abnormal_muscle_electrophysio1.10981289
79MP0000383_abnormal_hair_follicle1.10147368
80MP0001299_abnormal_eye_distance/1.05929699
81MP0004381_abnormal_hair_follicle1.04903260
82MP0004215_abnormal_myocardial_fiber1.04873501
83MP0005666_abnormal_adipose_tissue1.03018205
84* MP0002152_abnormal_brain_morphology1.02666252
85MP0005389_reproductive_system_phenotype1.02613169
86MP0004085_abnormal_heartbeat1.02549872
87MP0001188_hyperpigmentation1.01583819
88MP0003136_yellow_coat_color0.99486187
89MP0009250_abnormal_appendicular_skeleto0.98818048
90MP0003631_nervous_system_phenotype0.98674382
91MP0002971_abnormal_brown_adipose0.98032425
92MP0003634_abnormal_glial_cell0.97517756
93MP0004885_abnormal_endolymph0.97338506
94MP0004233_abnormal_muscle_weight0.96078379
95MP0003283_abnormal_digestive_organ0.95213462
96MP0003137_abnormal_impulse_conducting0.95125852
97MP0000604_amyloidosis0.94660803
98MP0005187_abnormal_penis_morphology0.94250213
99MP0003122_maternal_imprinting0.94090719
100MP0002751_abnormal_autonomic_nervous0.92889570
101MP0000534_abnormal_ureter_morphology0.91489833
102MP0008770_decreased_survivor_rate0.90266835
103MP0002876_abnormal_thyroid_physiology0.88997700
104MP0000747_muscle_weakness0.87682214
105MP0005171_absent_coat_pigmentation0.87175647
106MP0004484_altered_response_of0.85846329
107MP0010386_abnormal_urinary_bladder0.85729072
108MP0002132_abnormal_respiratory_system0.85694554
109MP0005174_abnormal_tail_pigmentation0.83342452
110MP0003938_abnormal_ear_development0.82459163
111MP0008932_abnormal_embryonic_tissue0.81565746
112MP0000013_abnormal_adipose_tissue0.80299090
113MP0004130_abnormal_muscle_cell0.79702784
114MP0001905_abnormal_dopamine_level0.77735890
115MP0002229_neurodegeneration0.77026544
116MP0004084_abnormal_cardiac_muscle0.76713121
117MP0002752_abnormal_somatic_nervous0.75312816
118MP0008873_increased_physiological_sensi0.75097567
119MP0000631_abnormal_neuroendocrine_gland0.75054712
120MP0000467_abnormal_esophagus_morphology0.74677622
121MP0001986_abnormal_taste_sensitivity0.74530668
122MP0002111_abnormal_tail_morphology0.73670202
123MP0003646_muscle_fatigue0.73545890
124MP0008874_decreased_physiological_sensi0.72959082
125MP0002069_abnormal_eating/drinking_beha0.72491174
126MP0005394_taste/olfaction_phenotype0.71938964
127MP0005499_abnormal_olfactory_system0.71938964
128MP0008961_abnormal_basal_metabolism0.70909426
129MP0003111_abnormal_nucleus_morphology0.70736543
130MP0003942_abnormal_urinary_system0.70093937
131MP0002972_abnormal_cardiac_muscle0.69877216
132* MP0003861_abnormal_nervous_system0.69847225
133MP0005195_abnormal_posterior_eye0.69586376
134MP0001270_distended_abdomen0.68143447
135MP0000428_abnormal_craniofacial_morphol0.68111539
136MP0005620_abnormal_muscle_contractility0.68053808
137MP0008872_abnormal_physiological_respon0.67030915
138MP0000749_muscle_degeneration0.66813028
139MP0003718_maternal_effect0.66471710
140MP0002116_abnormal_craniofacial_bone0.66351489
141MP0010678_abnormal_skin_adnexa0.66291064
142MP0001502_abnormal_circadian_rhythm0.66259524
143MP0000627_abnormal_mammary_gland0.64608266
144MP0002086_abnormal_extraembryonic_tissu0.64474350
145MP0005645_abnormal_hypothalamus_physiol0.64453761
146MP0004036_abnormal_muscle_relaxation0.64146570
147MP0005535_abnormal_body_temperature0.62249177
148MP0004142_abnormal_muscle_tone0.61924606
149MP0009115_abnormal_fat_cell0.61481514
150MP0008789_abnormal_olfactory_epithelium0.60971015
151MP0001529_abnormal_vocalization0.60685438
152MP0002060_abnormal_skin_morphology0.60116587
153MP0009379_abnormal_foot_pigmentation0.59462994
154MP0005646_abnormal_pituitary_gland0.59046827
155MP0003632_abnormal_nervous_system0.57527812
156MP0004087_abnormal_muscle_fiber0.56821422
157MP0005409_darkened_coat_color0.55838337
158MP0004957_abnormal_blastocyst_morpholog0.55737892
159MP0001177_atelectasis0.55229966
160MP0006035_abnormal_mitochondrial_morpho0.54959031
161MP0001943_abnormal_respiration0.54285872
162MP0000759_abnormal_skeletal_muscle0.54218281
163MP0002269_muscular_atrophy0.53996602
164MP0001340_abnormal_eyelid_morphology0.53202433
165MP0001119_abnormal_female_reproductive0.52952477
166MP0008775_abnormal_heart_ventricle0.51416488
167MP0004197_abnormal_fetal_growth/weight/0.51225369
168MP0010769_abnormal_survival0.50378396
169MP0008877_abnormal_DNA_methylation0.50132358
170MP0001963_abnormal_hearing_physiology0.49820420
171MP0002084_abnormal_developmental_patter0.48864224
172MP0000490_abnormal_crypts_of0.48725907
173MP0002697_abnormal_eye_size0.48405692
174MP0006036_abnormal_mitochondrial_physio0.48202637
175MP0005075_abnormal_melanosome_morpholog0.47756731
176MP0002249_abnormal_larynx_morphology0.47157405
177MP0000477_abnormal_intestine_morphology0.46821195
178MP0000613_abnormal_salivary_gland0.44371109
179MP0000470_abnormal_stomach_morphology0.43546036
180MP0002135_abnormal_kidney_morphology0.41204720
181MP0002095_abnormal_skin_pigmentation0.40761101
182MP0002109_abnormal_limb_morphology0.37378901
183MP0005375_adipose_tissue_phenotype0.36838249

Predicted human phenotypes

RankGene SetZ-score
1Short 1st metacarpal (HP:0010034)8.97009929
2Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)8.97009929
3Abnormality of the 1st metacarpal (HP:0010009)7.88458244
4Stenosis of the external auditory canal (HP:0000402)7.39810753
5Myokymia (HP:0002411)6.58703943
6Ectopic kidney (HP:0000086)6.43311003
7Carpal bone hypoplasia (HP:0001498)6.04603323
8Short phalanx of the thumb (HP:0009660)5.85442267
9Fused cervical vertebrae (HP:0002949)5.46198936
10Rectal fistula (HP:0100590)5.15634860
11Rectovaginal fistula (HP:0000143)5.15634860
12Chromosomal breakage induced by crosslinking agents (HP:0003221)5.15154746
13Focal motor seizures (HP:0011153)5.11793854
14Short hallux (HP:0010109)4.71818413
15Intestinal fistula (HP:0100819)4.69873371
16Absent thumb (HP:0009777)4.68922384
17Focal seizures (HP:0007359)4.58333506
18Abnormality of the renal collecting system (HP:0004742)4.51658430
19Duplicated collecting system (HP:0000081)4.51570213
20Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.48887271
21Vaginal fistula (HP:0004320)4.48518786
22Chromsome breakage (HP:0040012)4.47545479
23Aplasia/Hypoplasia of the hallux (HP:0008362)4.34296691
24Visual hallucinations (HP:0002367)4.32346181
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.27711271
26Action tremor (HP:0002345)4.19104525
27Supranuclear gaze palsy (HP:0000605)4.02767685
28Insidious onset (HP:0003587)4.02604145
29Termporal pattern (HP:0011008)4.02604145
30Ulnar claw (HP:0001178)3.96241860
31Absent radius (HP:0003974)3.94197937
32Oligomenorrhea (HP:0000876)3.90928420
33Short humerus (HP:0005792)3.82208419
34Aplasia/Hypoplasia involving the musculature (HP:0001460)3.82032032
35Synostosis of carpal bones (HP:0005048)3.76141417
36Hypoalphalipoproteinemia (HP:0003233)3.75159774
37Aplasia involving forearm bones (HP:0009822)3.73421636
38Absent forearm bone (HP:0003953)3.73421636
39Abnormality of the parathyroid morphology (HP:0011766)3.60618932
40Abnormality of DNA repair (HP:0003254)3.58219625
41Ankle clonus (HP:0011448)3.57147470
42Horseshoe kidney (HP:0000085)3.51727684
43Aplasia/hypoplasia of the humerus (HP:0006507)3.51161119
44Atonic seizures (HP:0010819)3.42193566
45Epileptic encephalopathy (HP:0200134)3.40590267
46Toxemia of pregnancy (HP:0100603)3.35269780
47Reduced subcutaneous adipose tissue (HP:0003758)3.34034956
48Progressive cerebellar ataxia (HP:0002073)3.27642731
49Decreased subcutaneous fat (HP:0001002)3.25103859
50Short thumb (HP:0009778)3.23685346
51Acanthocytosis (HP:0001927)3.20496810
52Anal stenosis (HP:0002025)3.15155519
53Abnormality of the carotid arteries (HP:0005344)3.12189778
54Reticulocytopenia (HP:0001896)3.10705742
55Absence seizures (HP:0002121)3.08869044
56Febrile seizures (HP:0002373)3.07782294
57Mutism (HP:0002300)3.07648380
58Pheochromocytoma (HP:0002666)3.05651241
59Osteomalacia (HP:0002749)3.01907780
60Generalized tonic-clonic seizures (HP:0002069)2.96384532
61Urinary bladder sphincter dysfunction (HP:0002839)2.88703972
62Urinary urgency (HP:0000012)2.85864348
63Papilledema (HP:0001085)2.85196617
64Insulin-resistant diabetes mellitus (HP:0000831)2.82055458
65Dialeptic seizures (HP:0011146)2.79592886
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.75484437
67Vitreoretinal degeneration (HP:0000655)2.75117072
68Impaired pain sensation (HP:0007328)2.72465266
69Abnormality of pain sensation (HP:0010832)2.72465266
70Maternal diabetes (HP:0009800)2.72306100
71Abnormality of pyrimidine metabolism (HP:0004353)2.71570522
72Optic nerve coloboma (HP:0000588)2.71022329
73Choanal stenosis (HP:0000452)2.69942382
74Abnormality of the lower motor neuron (HP:0002366)2.69691645
75Abnormality of the nasal septum (HP:0000419)2.67698464
76Pendular nystagmus (HP:0012043)2.65414032
77Amblyopia (HP:0000646)2.63495901
78Poor eye contact (HP:0000817)2.62921184
79Depression (HP:0000716)2.62816044
80Abnormality of the corticospinal tract (HP:0002492)2.59309255
81Impaired vibration sensation in the lower limbs (HP:0002166)2.59202772
82Neuroendocrine neoplasm (HP:0100634)2.58875526
83Torticollis (HP:0000473)2.58488665
84Neoplasm of the oral cavity (HP:0100649)2.58038874
85Vertebral fusion (HP:0002948)2.57921613
86Abnormality of the proximal phalanges of the hand (HP:0009834)2.57466006
87Carpal synostosis (HP:0009702)2.56292855
88Megalencephaly (HP:0001355)2.53323993
89Impaired social interactions (HP:0000735)2.53117125
90Abnormal social behavior (HP:0012433)2.53117125
91Ventricular fibrillation (HP:0001663)2.52753513
92Abnormality of subcutaneous fat tissue (HP:0001001)2.52665807
93Hyperuricemia (HP:0002149)2.51192681
94Increased purine levels (HP:0004368)2.51192681
95Truncal ataxia (HP:0002078)2.49933450
96Abnormal eating behavior (HP:0100738)2.49791530
97Preaxial foot polydactyly (HP:0001841)2.49222302
98Hammertoe (HP:0001765)2.49112168
99Limb dystonia (HP:0002451)2.47470128
100Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.39611802
101Spastic gait (HP:0002064)2.34635532
102Amyotrophic lateral sclerosis (HP:0007354)2.31783128
103Broad-based gait (HP:0002136)2.29995885
104Annular pancreas (HP:0001734)2.29932348
105Neoplasm of the peripheral nervous system (HP:0100007)2.28907815
106Anxiety (HP:0000739)2.28572034
107Focal dystonia (HP:0004373)2.28228514
108Cerebral inclusion bodies (HP:0100314)2.27849694
109Triphalangeal thumb (HP:0001199)2.26920193
110Myotonia (HP:0002486)2.26397069
111Bundle branch block (HP:0011710)2.26307817
112Congenital sensorineural hearing impairment (HP:0008527)2.24805377
113Rapidly progressive (HP:0003678)2.23625658
114Renal agenesis (HP:0000104)2.23242194
115Craniofacial dystonia (HP:0012179)2.22438087
116Apathy (HP:0000741)2.21525131
117Lower limb muscle weakness (HP:0007340)2.21500946
118Insomnia (HP:0100785)2.20939327
119Duplication of thumb phalanx (HP:0009942)2.18492939
120Meckel diverticulum (HP:0002245)2.18438183
121Tachypnea (HP:0002789)2.17724755
122Foot dorsiflexor weakness (HP:0009027)2.16991249
123Akinesia (HP:0002304)2.16822066
124Genetic anticipation (HP:0003743)2.14792081
125Postural instability (HP:0002172)2.14664241
126Hypoplasia of the brainstem (HP:0002365)2.14152080
127Aplasia/Hypoplasia of the brainstem (HP:0007362)2.14152080
128Ureteral duplication (HP:0000073)2.13677346
129Morphological abnormality of the middle ear (HP:0008609)2.12338527
130Tented upper lip vermilion (HP:0010804)2.11591711
131Hyperglycemia (HP:0003074)2.10145999
132Hypolipoproteinemia (HP:0010981)2.09951233
133Excessive salivation (HP:0003781)2.09691353
134Drooling (HP:0002307)2.09691353
135Esotropia (HP:0000565)2.09636022
136Polygenic inheritance (HP:0010982)2.09416817
137Segmental peripheral demyelination/remyelination (HP:0003481)2.09189137
138Synostosis involving bones of the hand (HP:0004278)2.07688383
139Abnormality of the ileum (HP:0001549)2.07398970
140Lower limb amyotrophy (HP:0007210)2.06608965
141EEG with generalized epileptiform discharges (HP:0011198)2.06586015
142Polyphagia (HP:0002591)2.06573737
143Sudden death (HP:0001699)2.05929961
144Hypsarrhythmia (HP:0002521)2.05072379
145Neurofibrillary tangles (HP:0002185)2.05049687
146Hypercortisolism (HP:0001578)2.05037715
147Bradykinesia (HP:0002067)2.04925410
148Pointed chin (HP:0000307)2.04524693
149Epileptiform EEG discharges (HP:0011182)2.03775422
150Hypoplasia of the ulna (HP:0003022)2.03457874
151Stereotypic behavior (HP:0000733)2.03239858
152Dysdiadochokinesis (HP:0002075)2.03059379
153Chorioretinal atrophy (HP:0000533)2.02831697
154Hypoventilation (HP:0002791)2.02707557
155Gaze-evoked nystagmus (HP:0000640)2.01340806
156Postural tremor (HP:0002174)1.99929700
157Steppage gait (HP:0003376)1.98985326
158Failure to thrive in infancy (HP:0001531)1.98856246
159Abnormality of the foot musculature (HP:0001436)1.98731160
160Fetal akinesia sequence (HP:0001989)1.97808072
161Diminished motivation (HP:0000745)1.97391337
162Abnormality of the preputium (HP:0100587)1.97316492
163Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.97245179
164Abnormality of chromosome stability (HP:0003220)1.97038596
165Severe muscular hypotonia (HP:0006829)1.96949826
166Progressive inability to walk (HP:0002505)1.96083142
167Agitation (HP:0000713)1.95770541
168Status epilepticus (HP:0002133)1.94677598
169External ophthalmoplegia (HP:0000544)1.92416239
170Resting tremor (HP:0002322)1.91753709
171Onion bulb formation (HP:0003383)1.91244385
172Hyperventilation (HP:0002883)1.90844318
173Lower limb asymmetry (HP:0100559)1.88647981
174Distal sensory impairment (HP:0002936)1.88344842
175Abnormality of the salivary glands (HP:0010286)1.87293785
176Dysmetria (HP:0001310)1.85803382
177Hemiparesis (HP:0001269)1.84936703
178Abnormality of nucleobase metabolism (HP:0010932)1.84327804
179Absent toe (HP:0010760)1.83652641
180Obstructive sleep apnea (HP:0002870)1.83252075
181Abnormality of the musculature of the hand (HP:0001421)1.82721196
182Morphological abnormality of the pyramidal tract (HP:0002062)1.82557939
183Abnormality of the humerus (HP:0003063)1.80236582
184Hypoplastic iliac wings (HP:0002866)1.79771545
185Hypoplasia of the radius (HP:0002984)1.79388147
186Impaired smooth pursuit (HP:0007772)1.79210864
187Clubbing of toes (HP:0100760)1.77349243
188Aqueductal stenosis (HP:0002410)1.76290189
189Clonus (HP:0002169)1.75072619
190Dysmetric saccades (HP:0000641)1.74134337
191Wide intermamillary distance (HP:0006610)1.74109478
192Abnormality of the upper arm (HP:0001454)1.73348316
193Abnormality of the middle phalanges of the toes (HP:0010183)1.72933357
194Facial asymmetry (HP:0000324)1.72403348
195Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68108290
196Paralysis (HP:0003470)1.65477320
197Insulin resistance (HP:0000855)1.63963463
198Small intestinal stenosis (HP:0012848)1.63874229
199Duodenal stenosis (HP:0100867)1.63874229
200Erythroderma (HP:0001019)1.61669328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK96.35529978
2GRK15.53240046
3CDC74.91395260
4MARK14.51914327
5MAP3K94.22458257
6LATS13.99223533
7NTRK33.56233216
8MINK13.22888221
9FRK3.19254053
10NTRK12.80589990
11EPHA42.79386146
12KSR22.72071270
13LATS22.70069918
14STK38L2.67194382
15MAP3K42.61385907
16ACVR1B2.35430701
17PHKG12.32964421
18PHKG22.32964421
19DAPK22.30429493
20PAK62.29596975
21LMTK22.23973273
22ZAK2.13507942
23MAP2K71.98396675
24NTRK21.91153181
25ADRBK21.87232589
26MAP2K41.82338379
27CAMKK11.81455171
28MAP3K21.78195107
29NLK1.73797005
30BMPR1B1.71224093
31ATR1.67723165
32TAF11.66209512
33KSR11.59876071
34GRK51.57824595
35NEK91.57345349
36TLK11.57263763
37PRKD31.47054402
38CLK11.46550004
39RET1.41159655
40MELK1.40514580
41CDK51.39566292
42MAPK131.38529377
43MKNK21.36748361
44AURKA1.35888993
45CSNK1A1L1.30892399
46MAP3K121.29287905
47RIPK41.26634765
48CAMKK21.25160940
49TAOK11.18516465
50SCYL21.18080689
51NEK11.17986712
52SIK21.16873340
53MAPK111.15186598
54PLK21.13655083
55DAPK11.12827969
56STK381.09890819
57LIMK11.08825621
58ARAF1.06705730
59PRKCG1.04627907
60STK31.01497699
61PNCK1.00140768
62CASK0.99036469
63TRIB30.97489998
64PAK30.91185768
65CSNK1D0.90533053
66CDK140.89548782
67UHMK10.89245225
68INSRR0.88537794
69PLK40.88359615
70DYRK30.88168284
71BRSK20.87272854
72PLK10.86038638
73CSNK1G30.85169122
74DYRK20.84218140
75ALK0.83719378
76CSNK1G20.82886301
77RIPK10.82241395
78MAP2K10.80279350
79CSNK1G10.79534035
80CDK180.78495626
81MARK20.78210085
82CDK150.77893592
83BRD40.77633895
84TTK0.77049123
85NEK20.73721435
86TYRO30.72961133
87SGK2230.72312129
88SGK4940.72312129
89RPS6KA20.71836214
90PINK10.70007413
91STK110.69028707
92NUAK10.68739763
93PRKAA20.68204367
94FLT30.67943134
95FER0.66845540
96CSNK1A10.66091297
97CHEK20.65987486
98CDK11A0.65899638
99CAMK2A0.64255371
100CHEK10.63570279
101SGK30.63006968
102MUSK0.62648039
103PRKCZ0.62458166
104ATM0.62403623
105STK390.62378178
106MATK0.62045012
107MAPK80.60677141
108PKN20.58642279
109SGK20.57063348
110GSK3B0.56136485
111PDK30.55775821
112PDK40.55775821
113WNK10.55512111
114PDGFRA0.54611090
115MAP2K20.53776787
116RAF10.53660040
117PDPK10.53575646
118EPHB20.53518177
119PRKCH0.52999133
120TRIM280.52802766
121PTK2B0.52694509
122DDR20.51686175
123MAP3K10.51237988
124RPS6KB10.49571452
125CAMK10.48792836
126PRPF4B0.48261635
127PRKDC0.47980035
128TGFBR10.47971957
129MAP2K60.47890565
130SYK0.46744538
131CDC42BPA0.46594181
132PDK10.46160688
133MAPK140.46091782
134MAPK30.45600803
135CAMK1D0.45468242
136MAPK120.45145309
137MAPK90.44642948
138WEE10.43632603
139PRKCE0.43616012
140SGK10.43289872
141DYRK1A0.42786105
142CAMK1G0.42337263
143AKT30.42072296
144CSK0.41873920
145CDK190.41848865
146BRSK10.40621243
147CCNB10.40583067
148PRKCI0.39864130
149ADRBK10.39425546
150CDK120.39366793
151WNK40.39229892
152MAPK10.39144032
153DAPK30.37430068
154RPS6KA30.37319981
155MAPK100.36998206
156GRK70.35588778
157ERBB30.35362958
158ROCK10.34476878
159CAMK40.33702773
160FYN0.32888928
161CSNK2A10.32875337
162PRKAA10.32452590
163FES0.31745917
164TGFBR20.30129906
165EIF2AK30.28059444
166OXSR10.26851544
167RPS6KA50.26766601
168HIPK20.26181297
169TNIK0.25551640
170WNK30.24932267
171CDK20.23589861
172SMG10.22754147

Predicted pathways (KEGG)

RankGene SetZ-score
1Renin-angiotensin system_Homo sapiens_hsa046144.92179685
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.53951693
3Synaptic vesicle cycle_Homo sapiens_hsa047213.14914253
4Fanconi anemia pathway_Homo sapiens_hsa034603.11279643
5Sulfur metabolism_Homo sapiens_hsa009203.05506257
6Basal cell carcinoma_Homo sapiens_hsa052172.72930214
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.64571683
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.63969556
9Olfactory transduction_Homo sapiens_hsa047402.55207401
10Nicotine addiction_Homo sapiens_hsa050332.43939359
11Long-term potentiation_Homo sapiens_hsa047202.37054164
12Circadian entrainment_Homo sapiens_hsa047132.24623971
13Dopaminergic synapse_Homo sapiens_hsa047282.11285744
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.05356388
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04258769
16GABAergic synapse_Homo sapiens_hsa047272.02089430
17Glutamatergic synapse_Homo sapiens_hsa047242.01896644
18Amphetamine addiction_Homo sapiens_hsa050311.95702937
19Cholinergic synapse_Homo sapiens_hsa047251.92878140
20Homologous recombination_Homo sapiens_hsa034401.92794975
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.91215717
22Insulin secretion_Homo sapiens_hsa049111.90268171
23Selenocompound metabolism_Homo sapiens_hsa004501.90078191
24Morphine addiction_Homo sapiens_hsa050321.87131509
25Salivary secretion_Homo sapiens_hsa049701.80556652
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.79777908
27Gastric acid secretion_Homo sapiens_hsa049711.67688574
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66449829
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.63213270
30Gap junction_Homo sapiens_hsa045401.63064198
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.61966057
32GnRH signaling pathway_Homo sapiens_hsa049121.58615567
33Renin secretion_Homo sapiens_hsa049241.58429954
34Phototransduction_Homo sapiens_hsa047441.57261189
35Oxytocin signaling pathway_Homo sapiens_hsa049211.55854394
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.50348600
37Long-term depression_Homo sapiens_hsa047301.49209111
38Taste transduction_Homo sapiens_hsa047421.47168624
39Glioma_Homo sapiens_hsa052141.45417439
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.44199225
41Systemic lupus erythematosus_Homo sapiens_hsa053221.36175440
42Estrogen signaling pathway_Homo sapiens_hsa049151.34719871
43Axon guidance_Homo sapiens_hsa043601.34537958
44Serotonergic synapse_Homo sapiens_hsa047261.29831456
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.28869530
46Cocaine addiction_Homo sapiens_hsa050301.26743385
47Calcium signaling pathway_Homo sapiens_hsa040201.25729886
48Oocyte meiosis_Homo sapiens_hsa041141.23405888
49Type II diabetes mellitus_Homo sapiens_hsa049301.21861141
50RNA degradation_Homo sapiens_hsa030181.21284977
51TGF-beta signaling pathway_Homo sapiens_hsa043501.20918719
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20233004
53Glycerolipid metabolism_Homo sapiens_hsa005611.18863264
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18478784
55ErbB signaling pathway_Homo sapiens_hsa040121.18134675
56Cardiac muscle contraction_Homo sapiens_hsa042601.16518098
57Galactose metabolism_Homo sapiens_hsa000521.16280754
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15895191
59Melanogenesis_Homo sapiens_hsa049161.14744169
60Dorso-ventral axis formation_Homo sapiens_hsa043201.14321881
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10366664
62Neurotrophin signaling pathway_Homo sapiens_hsa047221.10359955
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08190459
64Collecting duct acid secretion_Homo sapiens_hsa049661.07508685
65cAMP signaling pathway_Homo sapiens_hsa040241.07398766
66Chemical carcinogenesis_Homo sapiens_hsa052041.03102232
67mTOR signaling pathway_Homo sapiens_hsa041501.02564728
68Dilated cardiomyopathy_Homo sapiens_hsa054141.02305897
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01389076
70Lysine degradation_Homo sapiens_hsa003101.00463288
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99489845
72Endometrial cancer_Homo sapiens_hsa052130.99421688
73VEGF signaling pathway_Homo sapiens_hsa043700.98103786
74Pathways in cancer_Homo sapiens_hsa052000.96824366
75Insulin signaling pathway_Homo sapiens_hsa049100.92128131
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.89497731
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.88624209
78PPAR signaling pathway_Homo sapiens_hsa033200.86575474
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.83970086
80DNA replication_Homo sapiens_hsa030300.83254540
81Sphingolipid metabolism_Homo sapiens_hsa006000.80679128
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78081564
83Choline metabolism in cancer_Homo sapiens_hsa052310.77075004
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76634561
85Renal cell carcinoma_Homo sapiens_hsa052110.76530901
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.76016949
87MAPK signaling pathway_Homo sapiens_hsa040100.75443417
88One carbon pool by folate_Homo sapiens_hsa006700.75199927
89Hematopoietic cell lineage_Homo sapiens_hsa046400.74941582
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73880846
91Glucagon signaling pathway_Homo sapiens_hsa049220.72147358
92Rap1 signaling pathway_Homo sapiens_hsa040150.71676783
93p53 signaling pathway_Homo sapiens_hsa041150.70787418
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.70537287
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70075559
96Colorectal cancer_Homo sapiens_hsa052100.69664652
97Vibrio cholerae infection_Homo sapiens_hsa051100.69052081
98Cell cycle_Homo sapiens_hsa041100.68858202
99Endocytosis_Homo sapiens_hsa041440.66658942
100Thyroid hormone synthesis_Homo sapiens_hsa049180.66446858
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66095154
102Starch and sucrose metabolism_Homo sapiens_hsa005000.65507416
103Non-small cell lung cancer_Homo sapiens_hsa052230.64377143
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64338991
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62878149
106Histidine metabolism_Homo sapiens_hsa003400.62131870
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61759038
108Ras signaling pathway_Homo sapiens_hsa040140.61637170
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61572154
110Basal transcription factors_Homo sapiens_hsa030220.61523245
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60568550
112Ether lipid metabolism_Homo sapiens_hsa005650.60517264
113Thyroid cancer_Homo sapiens_hsa052160.60200475
114Prion diseases_Homo sapiens_hsa050200.59776894
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58512115
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57330083
117Pancreatic secretion_Homo sapiens_hsa049720.56323893
118Melanoma_Homo sapiens_hsa052180.54862423
119Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51815654
120Prolactin signaling pathway_Homo sapiens_hsa049170.51160198
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50966927
122Wnt signaling pathway_Homo sapiens_hsa043100.50762154
123FoxO signaling pathway_Homo sapiens_hsa040680.49346095
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48931998
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48415138
126Hedgehog signaling pathway_Homo sapiens_hsa043400.46706592
127Bile secretion_Homo sapiens_hsa049760.46419713
128Alcoholism_Homo sapiens_hsa050340.45911765
129N-Glycan biosynthesis_Homo sapiens_hsa005100.45556835
130Hippo signaling pathway_Homo sapiens_hsa043900.45465386
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45009747
132Tight junction_Homo sapiens_hsa045300.44911091
133ABC transporters_Homo sapiens_hsa020100.41210699
134Tryptophan metabolism_Homo sapiens_hsa003800.40803897
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40485195
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40210518
137Nitrogen metabolism_Homo sapiens_hsa009100.40159814
138AMPK signaling pathway_Homo sapiens_hsa041520.39002667
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38571294
140Alzheimers disease_Homo sapiens_hsa050100.38408978
141MicroRNAs in cancer_Homo sapiens_hsa052060.38123838
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36420897
143Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35360403
144Circadian rhythm_Homo sapiens_hsa047100.34972079
145Fat digestion and absorption_Homo sapiens_hsa049750.34888001
146Retinol metabolism_Homo sapiens_hsa008300.33898889
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33236504
148Nucleotide excision repair_Homo sapiens_hsa034200.31323173
149Mismatch repair_Homo sapiens_hsa034300.28334694
150Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27969180
151Prostate cancer_Homo sapiens_hsa052150.27958228
152mRNA surveillance pathway_Homo sapiens_hsa030150.27118111
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.26509425
154Vitamin digestion and absorption_Homo sapiens_hsa049770.23629823
155Butanoate metabolism_Homo sapiens_hsa006500.23085553
156Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22440944
157Primary immunodeficiency_Homo sapiens_hsa053400.21693318
158RNA polymerase_Homo sapiens_hsa030200.19393100

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