TTLL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.95878562
2positive regulation of mitochondrial fission (GO:0090141)4.64033972
3proline biosynthetic process (GO:0006561)4.51843394
4transcription from mitochondrial promoter (GO:0006390)4.50691768
5neuron cell-cell adhesion (GO:0007158)4.36795819
6sequestering of actin monomers (GO:0042989)4.29912828
7presynaptic membrane organization (GO:0097090)4.16658496
8vocalization behavior (GO:0071625)4.15823439
9synaptic vesicle exocytosis (GO:0016079)4.12488372
10synaptic vesicle endocytosis (GO:0048488)4.03460244
11* epithelial cilium movement (GO:0003351)4.00006574
12regulation of cAMP-dependent protein kinase activity (GO:2000479)3.99443942
13intraciliary transport (GO:0042073)3.97763270
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.97164315
15axonemal dynein complex assembly (GO:0070286)3.83470246
16behavioral response to nicotine (GO:0035095)3.81555352
17axonal fasciculation (GO:0007413)3.76272337
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.73584405
19cullin deneddylation (GO:0010388)3.69347063
20* cilium movement (GO:0003341)3.66310388
21regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64330298
22pyrimidine nucleobase catabolic process (GO:0006208)3.61197574
23regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.58039555
24protein localization to synapse (GO:0035418)3.57605253
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.56245989
26establishment of mitochondrion localization (GO:0051654)3.53985515
27mitochondrion transport along microtubule (GO:0047497)3.53625510
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.53625510
29response to pheromone (GO:0019236)3.53336165
30regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.53273388
31nonmotile primary cilium assembly (GO:0035058)3.52628203
32neuron recognition (GO:0008038)3.50932879
33positive regulation of synapse maturation (GO:0090129)3.50484857
34retinal ganglion cell axon guidance (GO:0031290)3.46775515
35cilium or flagellum-dependent cell motility (GO:0001539)3.46766501
36gamma-aminobutyric acid transport (GO:0015812)3.36322975
37regulation of respiratory system process (GO:0044065)3.35670635
38cerebral cortex radially oriented cell migration (GO:0021799)3.35508438
39neuronal ion channel clustering (GO:0045161)3.34819084
40glycosphingolipid biosynthetic process (GO:0006688)3.32497593
41* protein polyglutamylation (GO:0018095)3.32135732
42postsynaptic membrane organization (GO:0001941)3.30837911
43regulation of synaptic vesicle exocytosis (GO:2000300)3.29635569
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.28021037
45replication fork processing (GO:0031297)3.26948906
46regulation of glutamate receptor signaling pathway (GO:1900449)3.24867436
47sperm motility (GO:0030317)3.23956694
48negative regulation of microtubule polymerization (GO:0031115)3.23373326
49calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.21276111
50glutamate secretion (GO:0014047)3.21122848
51protein deneddylation (GO:0000338)3.20974864
52negative regulation of JAK-STAT cascade (GO:0046426)3.19722398
53cilium morphogenesis (GO:0060271)3.16791195
54dendritic spine morphogenesis (GO:0060997)3.15616116
55cilium assembly (GO:0042384)3.14267353
56cilium organization (GO:0044782)3.13322822
57oxidative demethylation (GO:0070989)3.13034619
58transmission of nerve impulse (GO:0019226)3.11477684
59regulation of membrane depolarization (GO:0003254)3.11117252
60regulation of synapse maturation (GO:0090128)3.10337475
61positive regulation of synapse assembly (GO:0051965)3.10158774
62negative regulation of heart rate (GO:0010459)3.10157433
63spinal cord development (GO:0021510)3.09687884
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.07617020
65regulation of protein homooligomerization (GO:0032462)3.06164997
66membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05718083
67positive regulation of protein homooligomerization (GO:0032464)3.05060872
68proline metabolic process (GO:0006560)3.04380545
69protein localization to cilium (GO:0061512)3.04111157
70neuromuscular process controlling posture (GO:0050884)3.03932966
71neurotransmitter-gated ion channel clustering (GO:0072578)3.02955630
72regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.02591970
73positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00711122
74positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.00176609
75mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.00176609
76synapse assembly (GO:0007416)2.99352597
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99196476
78protein neddylation (GO:0045116)2.95729095
79DNA strand renaturation (GO:0000733)2.95139018
80acrosome reaction (GO:0007340)2.94839166
81positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92983527
82regulation of NFAT protein import into nucleus (GO:0051532)2.91748821
83presynaptic membrane assembly (GO:0097105)2.91691685
84histone arginine methylation (GO:0034969)2.91060301
85regulation of mitochondrial fission (GO:0090140)2.89722830
86cerebellar Purkinje cell differentiation (GO:0021702)2.88131622
87* axoneme assembly (GO:0035082)2.87944396
88negative regulation of dendrite morphogenesis (GO:0050774)2.87637025
89regulation of microtubule-based movement (GO:0060632)2.86271660
90establishment or maintenance of monopolar cell polarity (GO:0061339)2.86164532
91establishment of monopolar cell polarity (GO:0061162)2.86164532
92auditory receptor cell stereocilium organization (GO:0060088)2.85584516
93regulation of synaptic vesicle transport (GO:1902803)2.84955172
94auditory behavior (GO:0031223)2.84700436
95regulation of neuronal synaptic plasticity (GO:0048168)2.84653854
96regulation of respiratory gaseous exchange (GO:0043576)2.83525323
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.82819531
98microtubule severing (GO:0051013)2.82044651
99platelet dense granule organization (GO:0060155)2.81478889
100piRNA metabolic process (GO:0034587)2.80038308
101respiratory system process (GO:0003016)2.79079139
102peptidyl-arginine omega-N-methylation (GO:0035247)2.78716386
103motile cilium assembly (GO:0044458)2.78437013
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.78419227
105mechanosensory behavior (GO:0007638)2.75818873
106spermatid nucleus differentiation (GO:0007289)2.75011604
107neuromuscular synaptic transmission (GO:0007274)2.75000162
108metallo-sulfur cluster assembly (GO:0031163)2.72522126
109iron-sulfur cluster assembly (GO:0016226)2.72522126
110establishment of melanosome localization (GO:0032401)2.72213738
111synaptic vesicle maturation (GO:0016188)2.71522671
112regulation of development, heterochronic (GO:0040034)2.71362163
113L-serine transport (GO:0015825)2.70177508
114mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.69853766
115positive regulation of action potential (GO:0045760)2.69489663
116inner ear receptor stereocilium organization (GO:0060122)2.69318456
117cytoskeleton-dependent intracellular transport (GO:0030705)2.68843360
118behavioral response to ethanol (GO:0048149)2.67402267
119opioid receptor signaling pathway (GO:0038003)2.64858779
120neurotransmitter secretion (GO:0007269)2.64452233
121microtubule-based transport (GO:0010970)2.64415442
122DNA double-strand break processing (GO:0000729)2.64088909
123DNA integration (GO:0015074)2.64076704
124neuromuscular process (GO:0050905)2.64052151
125locomotory exploration behavior (GO:0035641)2.64014656
126regulation of synapse structural plasticity (GO:0051823)2.63371861
127embryonic process involved in female pregnancy (GO:0060136)2.62977603
128pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62883655
129negative regulation of protein oligomerization (GO:0032460)2.62577833
130regulation of collateral sprouting (GO:0048670)2.61846256
131C4-dicarboxylate transport (GO:0015740)2.60058239
132axon extension involved in axon guidance (GO:0048846)2.60029914
133neuron projection extension involved in neuron projection guidance (GO:1902284)2.60029914
134seminiferous tubule development (GO:0072520)2.59147207
135sialylation (GO:0097503)2.58639138
136negative regulation of Ras GTPase activity (GO:0034261)2.58052241
137establishment of pigment granule localization (GO:0051905)2.57787557
138negative regulation of dendrite development (GO:2000171)2.57063334
139regulation of microtubule polymerization (GO:0031113)2.55984432
140neuron-neuron synaptic transmission (GO:0007270)2.55896026
141nucleobase catabolic process (GO:0046113)2.55206368
142melanosome transport (GO:0032402)2.55033298
143protein targeting to Golgi (GO:0000042)2.54841637
144anterograde axon cargo transport (GO:0008089)2.54299162
145synaptic vesicle transport (GO:0048489)2.53557988
146establishment of synaptic vesicle localization (GO:0097480)2.53557988
147substrate-independent telencephalic tangential migration (GO:0021826)2.52739006
148substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.52739006
149pyrimidine nucleotide catabolic process (GO:0006244)2.52251971
150melanosome localization (GO:0032400)2.52011758
151hippocampus development (GO:0021766)2.51795043
152central nervous system projection neuron axonogenesis (GO:0021952)2.50920604
153peptidyl-arginine N-methylation (GO:0035246)2.50566471
154peptidyl-arginine methylation (GO:0018216)2.50566471
155regulation of synapse assembly (GO:0051963)2.50012885
156forebrain neuron differentiation (GO:0021879)2.49260223
157negative regulation of response to food (GO:0032096)2.48511961
158negative regulation of appetite (GO:0032099)2.48511961
159exploration behavior (GO:0035640)2.47444885
160microtubule depolymerization (GO:0007019)2.46971060
161regulation of excitatory postsynaptic membrane potential (GO:0060079)2.46698058
162cerebral cortex cell migration (GO:0021795)2.46547539
163dendritic spine organization (GO:0097061)2.46426987
164regulation of cilium movement (GO:0003352)2.46307170
165pyrimidine dimer repair (GO:0006290)2.45044793
166synaptic transmission, glutamatergic (GO:0035249)2.44603835
167cell communication by electrical coupling (GO:0010644)2.44040692
168regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.43432527
169layer formation in cerebral cortex (GO:0021819)2.42839605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83124005
2IGF1R_20145208_ChIP-Seq_DFB_Human3.72828003
3GBX2_23144817_ChIP-Seq_PC3_Human2.90889269
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.83639434
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.78347603
6REST_21632747_ChIP-Seq_MESCs_Mouse2.61084844
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.50628081
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.50013670
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45077865
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.41276301
11* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29085119
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.26642478
13ERG_21242973_ChIP-ChIP_JURKAT_Human2.22470696
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22276415
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21983601
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.19767403
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16637808
18FUS_26573619_Chip-Seq_HEK293_Human2.08449828
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.06349577
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03545436
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.00902927
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.98137498
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93746693
24* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93364085
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.93084684
26SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.93003232
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91298671
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87467609
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86303184
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86303184
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79344261
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78569102
33RNF2_27304074_Chip-Seq_NSC_Mouse1.76356553
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.75338388
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73823385
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71503023
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.70826295
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70825123
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.70145293
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69815256
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.65743712
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.63072195
43* CBX2_27304074_Chip-Seq_ESCs_Mouse1.62021727
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61535868
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59400317
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57676150
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57178598
48* GABP_17652178_ChIP-ChIP_JURKAT_Human1.52760613
49IRF1_19129219_ChIP-ChIP_H3396_Human1.51638102
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.51464648
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50169827
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.43771110
53RING1B_27294783_Chip-Seq_NPCs_Mouse1.42355173
54ZNF274_21170338_ChIP-Seq_K562_Hela1.38871887
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.37652221
56AR_21572438_ChIP-Seq_LNCaP_Human1.37645309
57EWS_26573619_Chip-Seq_HEK293_Human1.36367736
58VDR_22108803_ChIP-Seq_LS180_Human1.35918117
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35814551
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35386477
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33796919
62CBP_20019798_ChIP-Seq_JUKART_Human1.32410832
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32410832
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.31979182
65DROSHA_22980978_ChIP-Seq_HELA_Human1.29371540
66TAF15_26573619_Chip-Seq_HEK293_Human1.29158303
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28270033
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27347187
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25627368
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.24765088
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24533039
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24460013
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23747045
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23587159
75TP53_22573176_ChIP-Seq_HFKS_Human1.20904527
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20827350
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.20058774
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19440762
79AR_25329375_ChIP-Seq_VCAP_Human1.17381730
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.16593919
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15639844
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14075693
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12074599
84* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11751295
85CTCF_27219007_Chip-Seq_Bcells_Human1.11629687
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.11472890
87TET1_21490601_ChIP-Seq_MESCs_Mouse1.11460306
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08420108
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.08190818
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.07604600
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07282172
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.05298748
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05076185
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04996518
95STAT3_23295773_ChIP-Seq_U87_Human1.04957832
96ER_23166858_ChIP-Seq_MCF-7_Human1.04381863
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03953783
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03562667
99SALL1_21062744_ChIP-ChIP_HESCs_Human1.02778261
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02359426
101ETS1_20019798_ChIP-Seq_JURKAT_Human1.02197457
102MYC_18940864_ChIP-ChIP_HL60_Human1.01468268
103IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01288542
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00870947
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00679112
106RUNX2_22187159_ChIP-Seq_PCA_Human1.00205114
107CREB1_15753290_ChIP-ChIP_HEK293T_Human0.99609870
108SOX2_16153702_ChIP-ChIP_HESCs_Human0.98515736
109HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98247625
110POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97567054
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96896401
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96896401
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96892726
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96349033
115KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95537133
116* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95474834
117MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95338028
118NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95019276
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94430707
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.94373731
121PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93109826
122SMAD4_21799915_ChIP-Seq_A2780_Human0.93024639
123VDR_23849224_ChIP-Seq_CD4+_Human0.93013990
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.91620133
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91379099
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.91303047
127* SOX2_21211035_ChIP-Seq_LN229_Gbm0.91140896
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91129407
129EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90461282
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90124205
131CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89161884
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87686156
133RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87418419
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87377970
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87377970
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87377970
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87343710
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87336081
139NANOG_21062744_ChIP-ChIP_HESCs_Human0.86254133
140NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.85982889
141DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85506643
142CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85384730
143P300_19829295_ChIP-Seq_ESCs_Human0.85016695
144SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84384885
145ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.81897758
146SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81557848
147KDM2B_26808549_Chip-Seq_K562_Human0.80707377
148SOX9_26525672_Chip-Seq_HEART_Mouse0.80701386
149PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80661036
150TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80480430
151POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80380718
152NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.80024240
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79270930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.43540061
2MP0005423_abnormal_somatic_nervous3.41763966
3MP0003880_abnormal_central_pattern3.08497804
4MP0003635_abnormal_synaptic_transmissio2.56438090
5MP0005645_abnormal_hypothalamus_physiol2.49446231
6MP0002063_abnormal_learning/memory/cond2.47722542
7MP0002653_abnormal_ependyma_morphology2.42136924
8MP0002735_abnormal_chemical_nociception2.39959752
9MP0001968_abnormal_touch/_nociception2.36406279
10MP0000751_myopathy2.35245844
11MP0009046_muscle_twitch2.34700808
12MP0005171_absent_coat_pigmentation2.31565347
13MP0004233_abnormal_muscle_weight2.30070469
14MP0002572_abnormal_emotion/affect_behav2.27651454
15MP0000778_abnormal_nervous_system2.26743299
16MP0008995_early_reproductive_senescence2.25063851
17MP0006276_abnormal_autonomic_nervous2.21912751
18MP0004270_analgesia2.18631902
19MP0002102_abnormal_ear_morphology2.16231192
20MP0002733_abnormal_thermal_nociception2.15574322
21MP0002064_seizures2.14450068
22MP0003011_delayed_dark_adaptation2.10167105
23MP0009745_abnormal_behavioral_response2.05228346
24MP0002184_abnormal_innervation1.99727559
25MP0010030_abnormal_orbit_morphology1.97874302
26MP0002736_abnormal_nociception_after1.95421380
27MP0002638_abnormal_pupillary_reflex1.91156384
28MP0001970_abnormal_pain_threshold1.88599875
29MP0002734_abnormal_mechanical_nocicepti1.85956962
30MP0003122_maternal_imprinting1.84951825
31MP0002837_dystrophic_cardiac_calcinosis1.81012801
32MP0003137_abnormal_impulse_conducting1.79985223
33MP0005646_abnormal_pituitary_gland1.78552287
34MP0001529_abnormal_vocalization1.75754835
35MP0003646_muscle_fatigue1.68160127
36MP0002272_abnormal_nervous_system1.65864293
37MP0002067_abnormal_sensory_capabilities1.63520577
38MP0004811_abnormal_neuron_physiology1.61886847
39MP0001984_abnormal_olfaction1.60129192
40MP0000955_abnormal_spinal_cord1.55365074
41MP0001440_abnormal_grooming_behavior1.51317700
42MP0002751_abnormal_autonomic_nervous1.49753532
43MP0000049_abnormal_middle_ear1.49208745
44MP0006072_abnormal_retinal_apoptosis1.48417881
45MP0001486_abnormal_startle_reflex1.48100807
46MP0004142_abnormal_muscle_tone1.46573053
47MP0004924_abnormal_behavior1.44142821
48MP0005386_behavior/neurological_phenoty1.44142821
49MP0002882_abnormal_neuron_morphology1.38933400
50MP0005248_abnormal_Harderian_gland1.37353195
51MP0002234_abnormal_pharynx_morphology1.32589785
52MP0001502_abnormal_circadian_rhythm1.31846530
53MP0005084_abnormal_gallbladder_morpholo1.31402746
54MP0002557_abnormal_social/conspecific_i1.28876499
55MP0004215_abnormal_myocardial_fiber1.28825007
56MP0004133_heterotaxia1.28710457
57MP0005410_abnormal_fertilization1.27708357
58MP0008877_abnormal_DNA_methylation1.24870323
59MP0002066_abnormal_motor_capabilities/c1.19496492
60MP0003787_abnormal_imprinting1.18871041
61MP0002233_abnormal_nose_morphology1.17145182
62MP0003698_abnormal_male_reproductive1.13827249
63MP0008057_abnormal_DNA_replication1.13647351
64MP0000631_abnormal_neuroendocrine_gland1.12300518
65MP0001986_abnormal_taste_sensitivity1.12150489
66MP0004858_abnormal_nervous_system1.11318933
67MP0001485_abnormal_pinna_reflex1.10109849
68MP0002152_abnormal_brain_morphology1.08384051
69MP0003786_premature_aging1.06878591
70MP0002752_abnormal_somatic_nervous1.05842514
71MP0003119_abnormal_digestive_system1.03420760
72MP0008569_lethality_at_weaning1.02185308
73MP0001293_anophthalmia1.02150737
74MP0004084_abnormal_cardiac_muscle1.00676913
75MP0001188_hyperpigmentation0.97491926
76MP0003890_abnormal_embryonic-extraembry0.97357753
77MP0004085_abnormal_heartbeat0.95386418
78MP0001905_abnormal_dopamine_level0.93599331
79MP0005253_abnormal_eye_physiology0.93100585
80MP0002909_abnormal_adrenal_gland0.93026616
81MP0004134_abnormal_chest_morphology0.90652575
82MP0002332_abnormal_exercise_endurance0.89961055
83MP0002822_catalepsy0.89434738
84MP0001299_abnormal_eye_distance/0.89380558
85* MP0001929_abnormal_gametogenesis0.89353772
86MP0002160_abnormal_reproductive_system0.88661234
87MP0005391_vision/eye_phenotype0.88281617
88MP0003861_abnormal_nervous_system0.87107606
89MP0002269_muscular_atrophy0.86868815
90MP0005195_abnormal_posterior_eye0.86738400
91MP0003283_abnormal_digestive_organ0.86638163
92MP0000749_muscle_degeneration0.85306049
93MP0003938_abnormal_ear_development0.84216364
94MP0004145_abnormal_muscle_electrophysio0.84014603
95MP0005551_abnormal_eye_electrophysiolog0.83799073
96MP0002069_abnormal_eating/drinking_beha0.82984670
97MP0001501_abnormal_sleep_pattern0.82611252
98MP0001177_atelectasis0.82576582
99MP0003329_amyloid_beta_deposits0.82317650
100MP0000015_abnormal_ear_pigmentation0.82310254
101MP0008775_abnormal_heart_ventricle0.82095791
102MP0006292_abnormal_olfactory_placode0.81360994
103MP0003121_genomic_imprinting0.80498484
104MP0009278_abnormal_bone_marrow0.79908375
105MP0000566_synostosis0.79353269
106MP0000569_abnormal_digit_pigmentation0.77862449
107MP0002210_abnormal_sex_determination0.77374848
108MP0003879_abnormal_hair_cell0.77370287
109MP0005394_taste/olfaction_phenotype0.77352365
110MP0005499_abnormal_olfactory_system0.77352365
111MP0010386_abnormal_urinary_bladder0.76732597
112MP0008058_abnormal_DNA_repair0.75947016
113MP0004742_abnormal_vestibular_system0.75856139
114MP0000026_abnormal_inner_ear0.75143284
115MP0003878_abnormal_ear_physiology0.75065680
116MP0005377_hearing/vestibular/ear_phenot0.75065680
117MP0003385_abnormal_body_wall0.74794470
118MP0005330_cardiomyopathy0.74660744
119MP0003172_abnormal_lysosome_physiology0.74581357
120MP0001963_abnormal_hearing_physiology0.72488149
121MP0003718_maternal_effect0.72083518
122MP0004484_altered_response_of0.70925533
123MP0003942_abnormal_urinary_system0.69180495
124MP0000372_irregular_coat_pigmentation0.68725853
125MP0002106_abnormal_muscle_physiology0.68365967
126MP0005623_abnormal_meninges_morphology0.67605065
127MP0002229_neurodegeneration0.67056289
128* MP0002282_abnormal_trachea_morphology0.67028128
129MP0008789_abnormal_olfactory_epithelium0.65012860
130MP0010768_mortality/aging0.64878191
131MP0005367_renal/urinary_system_phenotyp0.63912759
132MP0000516_abnormal_urinary_system0.63912759

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.97711524
2Febrile seizures (HP:0002373)4.45514317
3Myokymia (HP:0002411)4.03160594
4Atonic seizures (HP:0010819)3.98701067
5True hermaphroditism (HP:0010459)3.93630133
6Epileptic encephalopathy (HP:0200134)3.93031515
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.90840121
8Pancreatic fibrosis (HP:0100732)3.86792701
9Failure to thrive in infancy (HP:0001531)3.74263862
10Pancreatic cysts (HP:0001737)3.61209778
11Amyotrophic lateral sclerosis (HP:0007354)3.55579460
12Pheochromocytoma (HP:0002666)3.55566876
13Neuroendocrine neoplasm (HP:0100634)3.40846666
14Retinal dysplasia (HP:0007973)3.40040822
15Fetal akinesia sequence (HP:0001989)3.37456166
16Focal seizures (HP:0007359)3.35600468
17Nephronophthisis (HP:0000090)3.34419345
18Abnormality of midbrain morphology (HP:0002418)3.31193801
19Molar tooth sign on MRI (HP:0002419)3.31193801
20Absence seizures (HP:0002121)3.24403809
21Abnormal ciliary motility (HP:0012262)3.12714207
22Occipital encephalocele (HP:0002085)3.09352925
23Abnormal respiratory motile cilium physiology (HP:0012261)3.03019259
24Visual hallucinations (HP:0002367)2.97674761
25Gait imbalance (HP:0002141)2.90330304
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.89313294
27Absent/shortened dynein arms (HP:0200106)2.89313294
28Narrow nasal bridge (HP:0000446)2.88998943
29Abnormality of the labia minora (HP:0012880)2.88466852
30Drooling (HP:0002307)2.85845228
31Tubulointerstitial nephritis (HP:0001970)2.84715943
32Aplasia/Hypoplasia of the tongue (HP:0010295)2.82642369
33Cortical dysplasia (HP:0002539)2.81101257
34Annular pancreas (HP:0001734)2.80236294
35Dialeptic seizures (HP:0011146)2.78797965
36Atrophy/Degeneration involving motor neurons (HP:0007373)2.71277789
37Chronic hepatic failure (HP:0100626)2.69518666
38Rhinitis (HP:0012384)2.68342799
39Hyperglycinemia (HP:0002154)2.67265546
40Lissencephaly (HP:0001339)2.65706223
41Abnormal eating behavior (HP:0100738)2.64568035
42Poor suck (HP:0002033)2.63195956
43Concave nail (HP:0001598)2.62920585
44Polyphagia (HP:0002591)2.61399455
45Excessive salivation (HP:0003781)2.59906822
46Hyperventilation (HP:0002883)2.59852517
47Cystic liver disease (HP:0006706)2.56278694
48Exercise-induced myalgia (HP:0003738)2.55877078
49Aplasia of the musculature (HP:0100854)2.55579328
50Congenital primary aphakia (HP:0007707)2.53469882
51Sclerocornea (HP:0000647)2.51224805
52Medial flaring of the eyebrow (HP:0010747)2.48830882
53Postaxial foot polydactyly (HP:0001830)2.48715819
54Abnormality of the renal medulla (HP:0100957)2.48509838
55Anencephaly (HP:0002323)2.47884858
56Limb dystonia (HP:0002451)2.41302200
57Colon cancer (HP:0003003)2.39305546
58Postaxial hand polydactyly (HP:0001162)2.38632034
59Nephrogenic diabetes insipidus (HP:0009806)2.35039727
60Absent speech (HP:0001344)2.34614462
61Abnormality of the corticospinal tract (HP:0002492)2.34194361
62Short tibia (HP:0005736)2.29014813
63Abnormal hair whorl (HP:0010721)2.28366252
64Specific learning disability (HP:0001328)2.27532915
65Broad-based gait (HP:0002136)2.27419828
66Broad foot (HP:0001769)2.26856828
67Abnormality of the aortic arch (HP:0012303)2.26788801
68Rectovaginal fistula (HP:0000143)2.26772457
69Rectal fistula (HP:0100590)2.26772457
70Sudden death (HP:0001699)2.25353602
71Acute encephalopathy (HP:0006846)2.25346650
72Primary atrial arrhythmia (HP:0001692)2.22392345
73Tongue fasciculations (HP:0001308)2.21644803
74Muscle fibrillation (HP:0010546)2.20248264
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18302191
76Abnormal respiratory epithelium morphology (HP:0012253)2.18238918
77Abnormal respiratory motile cilium morphology (HP:0005938)2.18238918
78Pachygyria (HP:0001302)2.16710721
79Congenital hepatic fibrosis (HP:0002612)2.16077366
80Progressive cerebellar ataxia (HP:0002073)2.15206419
81Spastic tetraplegia (HP:0002510)2.14679260
82Type II lissencephaly (HP:0007260)2.13370130
83Supraventricular tachycardia (HP:0004755)2.12553260
84Increased IgM level (HP:0003496)2.12378452
85Facial hemangioma (HP:0000329)2.11693182
86Atrial fibrillation (HP:0005110)2.11452669
87Abnormality of the lower motor neuron (HP:0002366)2.10620150
88Acute necrotizing encephalopathy (HP:0006965)2.10263210
89Neoplasm of the peripheral nervous system (HP:0100007)2.08754859
90Hepatocellular necrosis (HP:0001404)2.08413004
91Narrow forehead (HP:0000341)2.07895488
92Preaxial hand polydactyly (HP:0001177)2.07808607
93Generalized tonic-clonic seizures (HP:0002069)2.07708816
94Spastic gait (HP:0002064)2.07631712
95High anterior hairline (HP:0009890)2.05509102
96Rib fusion (HP:0000902)2.04448920
97Left ventricular hypertrophy (HP:0001712)2.03628314
98Orthostatic hypotension (HP:0001278)2.03403588
99Impaired vibration sensation in the lower limbs (HP:0002166)2.02821800
100Hamartoma (HP:0010566)2.02740206
101Supraventricular arrhythmia (HP:0005115)2.02705562
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.02400711
103Abnormal mitochondria in muscle tissue (HP:0008316)2.02196710
104Urinary urgency (HP:0000012)2.01467851
105Abnormal EKG (HP:0003115)2.00519605
106Intestinal fistula (HP:0100819)1.99681080
107Sleep apnea (HP:0010535)1.97606060
108Progressive sensorineural hearing impairment (HP:0000408)1.96101062
109Chronic bronchitis (HP:0004469)1.95638841
110Alacrima (HP:0000522)1.95179200
111Hand muscle atrophy (HP:0009130)1.92155153
112Male pseudohermaphroditism (HP:0000037)1.91836769
113Bifid uvula (HP:0000193)1.91388912
114Poor coordination (HP:0002370)1.90742815
115Esotropia (HP:0000565)1.89938486
116Broad alveolar ridges (HP:0000187)1.89346619
117Increased CSF lactate (HP:0002490)1.89291465
118Decreased testicular size (HP:0008734)1.89090084
119Amblyopia (HP:0000646)1.87907704
120Diminished movement (HP:0002374)1.86907219
121Dysautonomia (HP:0002459)1.86593663
122Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85661725
123Hypoplasia of the brainstem (HP:0002365)1.85661725
124Degeneration of the lateral corticospinal tracts (HP:0002314)1.85628720
125Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85628720
126Oligomenorrhea (HP:0000876)1.85366386
127Vaginal atresia (HP:0000148)1.84936306
128Genital tract atresia (HP:0001827)1.83434340
129Hypercortisolism (HP:0001578)1.82959038
130Male infertility (HP:0003251)1.82926688
131Hypsarrhythmia (HP:0002521)1.82293800
132Myotonia (HP:0002486)1.81837916
133Bifid tongue (HP:0010297)1.81566323
134Progressive macrocephaly (HP:0004481)1.79162826
135Akinesia (HP:0002304)1.78008296
136Morphological abnormality of the pyramidal tract (HP:0002062)1.77101747
137Bulbar palsy (HP:0001283)1.76866722
138Intellectual disability, moderate (HP:0002342)1.76689869
139Vaginal fistula (HP:0004320)1.76614914
140Optic nerve coloboma (HP:0000588)1.76572571
141Abnormality of the motor neurons (HP:0002450)1.74535789
142Abnormal neuron morphology (HP:0012757)1.74535789
143Renal dysplasia (HP:0000110)1.74142607
144Dysdiadochokinesis (HP:0002075)1.74129285
145Hepatic necrosis (HP:0002605)1.73962926
146Coronal craniosynostosis (HP:0004440)1.73699761
147Abnormality of the vocal cords (HP:0008777)1.72968770
148Type 2 muscle fiber atrophy (HP:0003554)1.72846468
149Short chin (HP:0000331)1.72835273
150Intestinal atresia (HP:0011100)1.71773529
151Growth hormone excess (HP:0000845)1.71753417
152Epileptiform EEG discharges (HP:0011182)1.71439643
153Severe visual impairment (HP:0001141)1.70929765
154Aplasia/Hypoplasia of the lens (HP:0008063)1.70685971
155Progressive inability to walk (HP:0002505)1.70262095
156Abnormality of the calf musculature (HP:0001430)1.69854150
157Anophthalmia (HP:0000528)1.69646622
158Oligodactyly (hands) (HP:0001180)1.69429486
159Poikiloderma (HP:0001029)1.69136280
160Abnormality of glycolysis (HP:0004366)1.69125979
161Increased serum pyruvate (HP:0003542)1.69125979
162Anteriorly placed anus (HP:0001545)1.69107125
163Hip dysplasia (HP:0001385)1.68582926
164Optic nerve hypoplasia (HP:0000609)1.68236906
165Congenital hip dislocation (HP:0001374)1.65864561
166EEG with generalized epileptiform discharges (HP:0011198)1.64019899
167Poor eye contact (HP:0000817)1.63668720
168Mitochondrial inheritance (HP:0001427)1.63006697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.84216812
2CASK4.01902198
3ICK3.45037519
4PRPF4B3.11226970
5MARK12.90689798
6BCKDK2.83659241
7MAP3K62.73955324
8TESK12.69202435
9PINK12.68251712
10DDR22.62539834
11SIK32.61689207
12TRIM282.55840797
13UHMK12.50090672
14DAPK12.47820408
15PHKG22.33868990
16PHKG12.33868990
17WNK32.28408051
18AKT32.17258172
19MAP3K42.07993609
20MAPK152.06163120
21MAP2K71.97586159
22NTRK31.97323603
23EPHA31.87597737
24MAP3K121.84071464
25TYRO31.76043476
26MINK11.74864167
27MAP3K111.74130763
28CSNK1G31.68523141
29MAP3K91.66456673
30CSNK1G21.66246043
31FGR1.62289775
32LATS21.61628335
33NTRK21.54651929
34MATK1.45986104
35DYRK31.45131843
36MAPK131.41356223
37DYRK21.40880726
38CSNK1A1L1.40016733
39YES11.38834391
40EPHA41.36913813
41CSNK1G11.30846723
42TESK21.20834591
43RPS6KL11.18232929
44RPS6KC11.18232929
45VRK21.11734520
46ERBB31.10570875
47PIM21.10422334
48TAOK21.09475864
49EPHB21.08387378
50PAK61.08364027
51KSR11.07653774
52PDK31.03591332
53PDK41.03591332
54PLK20.96515709
55NEK10.93901757
56CAMK2A0.93486794
57CDC42BPA0.93072618
58PRKD20.92728628
59RPS6KA60.92097542
60INSRR0.91378364
61PLK40.89643098
62MAP2K40.87546468
63DAPK20.86154394
64CDK50.85829006
65GRK50.83634905
66NUAK10.80807423
67CAMK2B0.78784993
68CDK180.78184041
69PDGFRA0.78101716
70DYRK1B0.77669750
71CCNB10.77514430
72LIMK10.76360567
73BCR0.76190739
74CDK190.76141515
75RPS6KA20.75537991
76IRAK20.73214358
77MAP3K50.72630378
78TIE10.72119447
79SRPK10.71759705
80BMX0.71406837
81RPS6KA40.70905425
82ADRBK20.70611656
83VRK10.70459893
84SIK20.65234479
85CDK150.65233852
86TNIK0.64687577
87PRKCG0.64493150
88CDK140.64445441
89CAMK2D0.64267831
90PNCK0.62775404
91LMTK20.61974122
92DYRK1A0.60693125
93ZAK0.59951094
94TNK20.59638327
95SGK20.57324099
96PRKAA10.57086258
97BRAF0.56157765
98OXSR10.54625626
99CDK11A0.54591772
100CAMK2G0.54517980
101PAK30.53644892
102MYLK0.51873630
103PRKCZ0.51596348
104SGK4940.51429849
105SGK2230.51429849
106AURKA0.50055316
107WNK40.48430560
108PKN10.48121656
109CDK80.45190538
110KDR0.45173303
111STK390.44082321
112BRSK10.43151596
113ARAF0.42962077
114NTRK10.42506108
115STK160.42400053
116SGK10.41158168
117RPS6KA10.40691188
118CAMK40.40069707
119PRKCE0.40060834
120PRKD30.39484345
121STK38L0.39193458
122BMPR1B0.39146143
123STK380.39087454
124TRPM70.38088009
125MARK20.37872591
126ADRBK10.37677869
127GRK10.37214688
128CAMKK20.37036838
129RAF10.35446450
130TSSK60.35400059
131MUSK0.34660374
132CSNK1A10.34354415
133RPS6KB10.34226611
134PRKACA0.34019970
135PDK20.33483385
136SGK30.33123679
137MAPK100.30763604
138RPS6KA50.30134597
139GRK70.30092259
140ATR0.29098535
141RPS6KA30.28637539
142ROCK20.28284547
143BRD40.25414039
144PLK10.24904524
145NME10.23391918

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.35668577
2Nicotine addiction_Homo sapiens_hsa050333.09533982
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.49055317
4Oxidative phosphorylation_Homo sapiens_hsa001902.41827678
5Cardiac muscle contraction_Homo sapiens_hsa042602.37828340
6Olfactory transduction_Homo sapiens_hsa047402.31738385
7Collecting duct acid secretion_Homo sapiens_hsa049662.23707625
8Parkinsons disease_Homo sapiens_hsa050122.18146513
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16793451
10Fatty acid biosynthesis_Homo sapiens_hsa000612.13302805
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07054888
12GABAergic synapse_Homo sapiens_hsa047272.05842520
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92042570
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91878801
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90599024
16Morphine addiction_Homo sapiens_hsa050321.88017820
17Steroid biosynthesis_Homo sapiens_hsa001001.81425352
18Protein export_Homo sapiens_hsa030601.74642765
19Circadian entrainment_Homo sapiens_hsa047131.70869548
20Huntingtons disease_Homo sapiens_hsa050161.69652936
21Dopaminergic synapse_Homo sapiens_hsa047281.67629528
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65061099
23Propanoate metabolism_Homo sapiens_hsa006401.62342110
24Butanoate metabolism_Homo sapiens_hsa006501.61243740
25Circadian rhythm_Homo sapiens_hsa047101.59522450
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59153053
27Taste transduction_Homo sapiens_hsa047421.56622965
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.56080918
29Alzheimers disease_Homo sapiens_hsa050101.53473556
30Amphetamine addiction_Homo sapiens_hsa050311.52515689
31Axon guidance_Homo sapiens_hsa043601.51406408
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51074709
33Glutamatergic synapse_Homo sapiens_hsa047241.47468641
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47152778
35Gap junction_Homo sapiens_hsa045401.46855707
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43869194
37Peroxisome_Homo sapiens_hsa041461.42824003
38Phototransduction_Homo sapiens_hsa047441.42474434
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40727305
40Long-term potentiation_Homo sapiens_hsa047201.38624700
41Serotonergic synapse_Homo sapiens_hsa047261.36642734
42Base excision repair_Homo sapiens_hsa034101.34569516
43Insulin secretion_Homo sapiens_hsa049111.32877502
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32407127
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.30001557
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.29187398
47Hedgehog signaling pathway_Homo sapiens_hsa043401.26606517
48Vibrio cholerae infection_Homo sapiens_hsa051101.25848040
49Fatty acid elongation_Homo sapiens_hsa000621.24640010
50Oocyte meiosis_Homo sapiens_hsa041141.22209243
51RNA polymerase_Homo sapiens_hsa030201.21376252
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15875070
53Dilated cardiomyopathy_Homo sapiens_hsa054141.13348474
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12921312
55Cholinergic synapse_Homo sapiens_hsa047251.12760375
56ErbB signaling pathway_Homo sapiens_hsa040121.11094780
57Hippo signaling pathway_Homo sapiens_hsa043901.07086819
58Oxytocin signaling pathway_Homo sapiens_hsa049211.04460531
59Basal transcription factors_Homo sapiens_hsa030221.02954482
60Calcium signaling pathway_Homo sapiens_hsa040201.02926145
61mTOR signaling pathway_Homo sapiens_hsa041501.02017091
62Salivary secretion_Homo sapiens_hsa049701.01234608
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.98043252
64Long-term depression_Homo sapiens_hsa047300.97967487
65Wnt signaling pathway_Homo sapiens_hsa043100.95182827
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93633022
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93306793
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93235092
69Fanconi anemia pathway_Homo sapiens_hsa034600.92693344
70mRNA surveillance pathway_Homo sapiens_hsa030150.90119026
71GnRH signaling pathway_Homo sapiens_hsa049120.89379956
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88955047
73Fatty acid metabolism_Homo sapiens_hsa012120.88788131
74Sulfur relay system_Homo sapiens_hsa041220.86620488
75Endometrial cancer_Homo sapiens_hsa052130.84705146
76RNA degradation_Homo sapiens_hsa030180.84205909
77RNA transport_Homo sapiens_hsa030130.84123843
78Mismatch repair_Homo sapiens_hsa034300.82402589
79Colorectal cancer_Homo sapiens_hsa052100.79736496
80Renin secretion_Homo sapiens_hsa049240.79625237
81beta-Alanine metabolism_Homo sapiens_hsa004100.79203081
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78108196
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77670313
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77658158
85Alcoholism_Homo sapiens_hsa050340.76893773
86Cocaine addiction_Homo sapiens_hsa050300.76409061
87Gastric acid secretion_Homo sapiens_hsa049710.72858716
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72255819
89MAPK signaling pathway_Homo sapiens_hsa040100.71681605
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71403822
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70818960
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70598251
93Insulin signaling pathway_Homo sapiens_hsa049100.70294798
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70230299
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69956509
96Phagosome_Homo sapiens_hsa041450.68838723
97Metabolic pathways_Homo sapiens_hsa011000.68332582
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.66696930
99cAMP signaling pathway_Homo sapiens_hsa040240.66013812
100Purine metabolism_Homo sapiens_hsa002300.64547898
101Fructose and mannose metabolism_Homo sapiens_hsa000510.64420383
102Basal cell carcinoma_Homo sapiens_hsa052170.63324951
103Melanogenesis_Homo sapiens_hsa049160.62870261
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62776943
105Estrogen signaling pathway_Homo sapiens_hsa049150.60558117
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60072955
107Notch signaling pathway_Homo sapiens_hsa043300.56665284
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55735436
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55425368
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.54349542
111VEGF signaling pathway_Homo sapiens_hsa043700.52356696
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51790862
113Glioma_Homo sapiens_hsa052140.51044529
114Glucagon signaling pathway_Homo sapiens_hsa049220.51030158
115Carbon metabolism_Homo sapiens_hsa012000.51011842
116Tyrosine metabolism_Homo sapiens_hsa003500.49932730
117Proteasome_Homo sapiens_hsa030500.49705037
118Pyrimidine metabolism_Homo sapiens_hsa002400.47695662
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47489095
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47376554
121Melanoma_Homo sapiens_hsa052180.47237382
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46582097
123Glutathione metabolism_Homo sapiens_hsa004800.46580795
124Choline metabolism in cancer_Homo sapiens_hsa052310.46487646
125Ras signaling pathway_Homo sapiens_hsa040140.45936642
126Folate biosynthesis_Homo sapiens_hsa007900.44943258
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.43804916
128Regulation of autophagy_Homo sapiens_hsa041400.43626164
129Pyruvate metabolism_Homo sapiens_hsa006200.43059265
130Biosynthesis of amino acids_Homo sapiens_hsa012300.42365325
131Nucleotide excision repair_Homo sapiens_hsa034200.42354265
132Dorso-ventral axis formation_Homo sapiens_hsa043200.42104760
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.41201884
134Arginine and proline metabolism_Homo sapiens_hsa003300.40687754
135Non-homologous end-joining_Homo sapiens_hsa034500.40318197
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.40197923
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38956968
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38490898
139Tight junction_Homo sapiens_hsa045300.36459093
140Phenylalanine metabolism_Homo sapiens_hsa003600.36012975
141Type II diabetes mellitus_Homo sapiens_hsa049300.35798127
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.33741072
143Endocytosis_Homo sapiens_hsa041440.33518427

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