TTLL11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)7.35659732
2muscle filament sliding (GO:0030049)6.35783469
3actin-myosin filament sliding (GO:0033275)6.35783469
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.85357666
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.71715028
6synaptic vesicle maturation (GO:0016188)5.47949109
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.45441678
8skeletal muscle contraction (GO:0003009)5.39124914
9locomotory exploration behavior (GO:0035641)5.22537323
10actin-mediated cell contraction (GO:0070252)5.20256453
11synaptic vesicle exocytosis (GO:0016079)5.15145455
12glutamate secretion (GO:0014047)5.11913580
13synaptic vesicle docking involved in exocytosis (GO:0016081)5.09987073
14vocalization behavior (GO:0071625)4.97217120
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94646581
16regulation of glutamate receptor signaling pathway (GO:1900449)4.74700690
17positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.69148588
18protein localization to synapse (GO:0035418)4.64802568
19regulation of synaptic vesicle exocytosis (GO:2000300)4.61172151
20striated muscle contraction (GO:0006941)4.38802866
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.36034194
22neuronal action potential propagation (GO:0019227)4.35125261
23regulation of synaptic vesicle transport (GO:1902803)4.31753815
24regulation of neuronal synaptic plasticity (GO:0048168)4.27014658
25actin filament-based movement (GO:0030048)4.22785706
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.20978164
27regulation of skeletal muscle contraction (GO:0014819)4.16837962
28neurotransmitter secretion (GO:0007269)4.15038629
29response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.14781795
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.11442620
31synaptic transmission, glutamatergic (GO:0035249)4.07431945
32glutamate receptor signaling pathway (GO:0007215)3.99831644
33exploration behavior (GO:0035640)3.98639566
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98241604
35regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.96179133
36negative regulation of potassium ion transmembrane transport (GO:1901380)3.94814236
37skeletal muscle fiber development (GO:0048741)3.93086440
38myofibril assembly (GO:0030239)3.91280914
39neuron cell-cell adhesion (GO:0007158)3.89714305
40sarcomere organization (GO:0045214)3.89627728
41neuron-neuron synaptic transmission (GO:0007270)3.86461262
42neurotransmitter-gated ion channel clustering (GO:0072578)3.86114966
43positive regulation of myotube differentiation (GO:0010831)3.77780230
44calcium ion-dependent exocytosis (GO:0017156)3.77766571
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72407911
46cardiac muscle contraction (GO:0060048)3.69858631
47regulation of synapse structural plasticity (GO:0051823)3.68030602
48regulation of relaxation of muscle (GO:1901077)3.67162219
49regulation of excitatory postsynaptic membrane potential (GO:0060079)3.65271265
50multicellular organism reproduction (GO:0032504)3.64791340
51positive regulation of membrane potential (GO:0045838)3.62486273
52layer formation in cerebral cortex (GO:0021819)3.62008165
53response to inactivity (GO:0014854)3.61527439
54long-term memory (GO:0007616)3.61263728
55membrane depolarization during action potential (GO:0086010)3.61123732
56piRNA metabolic process (GO:0034587)3.53222542
57regulation of synaptic plasticity (GO:0048167)3.51563542
58acrosome assembly (GO:0001675)3.51063971
59regulation of postsynaptic membrane potential (GO:0060078)3.44053457
60synaptic vesicle endocytosis (GO:0048488)3.42648719
61cytoskeletal anchoring at plasma membrane (GO:0007016)3.41413159
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.40425340
63regulation of dendritic spine morphogenesis (GO:0061001)3.40347368
64sperm motility (GO:0030317)3.38144353
65proline transport (GO:0015824)3.37311914
66dendritic spine morphogenesis (GO:0060997)3.36918750
67neurotransmitter transport (GO:0006836)3.35497053
68plasma membrane repair (GO:0001778)3.34952685
69response to muscle activity (GO:0014850)3.34571407
70gamma-aminobutyric acid transport (GO:0015812)3.33822117
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.33001838
72regulation of skeletal muscle cell differentiation (GO:2001014)3.32960341
73regulation of synaptic transmission, glutamatergic (GO:0051966)3.32071725
74muscle contraction (GO:0006936)3.31750282
75cellular potassium ion homeostasis (GO:0030007)3.30185955
76macroautophagy (GO:0016236)3.28855435
77myotube cell development (GO:0014904)3.28719763
78acrosome reaction (GO:0007340)3.27847846
79regulation of neurotransmitter secretion (GO:0046928)3.27736177
80positive regulation of neurotransmitter transport (GO:0051590)3.27498832
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26597912
82cardiac myofibril assembly (GO:0055003)3.25936587
83activation of protein kinase A activity (GO:0034199)3.24897781
84regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.24279782
85gamma-aminobutyric acid signaling pathway (GO:0007214)3.22346663
86long-term synaptic potentiation (GO:0060291)3.20200160
87sodium ion export (GO:0071436)3.18466094
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.17719035
89membrane depolarization (GO:0051899)3.17519994
90creatine metabolic process (GO:0006600)3.16988665
91regulation of actin filament-based movement (GO:1903115)3.16424833
92negative regulation of synaptic transmission, GABAergic (GO:0032229)3.16307950
93neuromuscular process controlling posture (GO:0050884)3.15806317
94regulation of neurotransmitter transport (GO:0051588)3.14924918
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14841626
96skeletal muscle adaptation (GO:0043501)3.12879717
97neuromuscular process controlling balance (GO:0050885)3.12859232
98regulation of vesicle fusion (GO:0031338)3.11243292
99regulation of ARF protein signal transduction (GO:0032012)3.10859789
100regulation of neurotransmitter levels (GO:0001505)3.10084827
101positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.09834700
102cell-substrate adherens junction assembly (GO:0007045)3.09608908
103focal adhesion assembly (GO:0048041)3.09608908
104actomyosin structure organization (GO:0031032)3.09144201
105regulation of cell communication by electrical coupling (GO:0010649)3.08720277
106cerebellar Purkinje cell differentiation (GO:0021702)3.08238453
107positive regulation of neurotransmitter secretion (GO:0001956)3.07768666
108prepulse inhibition (GO:0060134)3.07317823
109cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05625119
110behavioral defense response (GO:0002209)3.05342691
111behavioral fear response (GO:0001662)3.05342691
112protein targeting to plasma membrane (GO:0072661)3.05024141
113cilium or flagellum-dependent cell motility (GO:0001539)3.04899464
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04567731
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01531752
116reproduction (GO:0000003)3.00871711
117neuron recognition (GO:0008038)2.99217114
118myotube differentiation (GO:0014902)2.99160690
119regulation of calcium ion-dependent exocytosis (GO:0017158)2.98758569
120vesicle transport along microtubule (GO:0047496)2.98158242
121cellular response to epinephrine stimulus (GO:0071872)2.97390223
122positive regulation of synapse maturation (GO:0090129)2.96744076
123striatum development (GO:0021756)2.96711045
124cell wall macromolecule catabolic process (GO:0016998)2.95492994
125cell wall macromolecule metabolic process (GO:0044036)2.95492994
126transmission of nerve impulse (GO:0019226)2.95476348
127response to histamine (GO:0034776)2.94666039
128regulation of NFAT protein import into nucleus (GO:0051532)2.94412908
129intraspecies interaction between organisms (GO:0051703)2.94284337
130social behavior (GO:0035176)2.94284337
131muscle system process (GO:0003012)2.94072008
132negative regulation of cell size (GO:0045792)2.93506011
133regulation of clathrin-mediated endocytosis (GO:2000369)2.93284598
134myoblast fusion (GO:0007520)2.93224192
135neuronal ion channel clustering (GO:0045161)2.93210051
136regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.93085117
137regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.93085117
138positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.92622132
139positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91948678
140fusion of sperm to egg plasma membrane (GO:0007342)2.90187667
141sperm-egg recognition (GO:0035036)2.88191850
142regulation of synaptic transmission (GO:0050804)2.87884689
143behavioral response to cocaine (GO:0048148)2.87707837
144adherens junction assembly (GO:0034333)2.86601314
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86311223
146cerebellar granule cell differentiation (GO:0021707)2.85569277
147cell-substrate junction assembly (GO:0007044)2.84601547
148synaptic transmission (GO:0007268)2.84199384
149cardiac muscle hypertrophy (GO:0003300)2.84047340
150positive regulation of synaptic transmission (GO:0050806)2.83365518
151plasma membrane fusion (GO:0045026)2.82973759
152regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82458070
153syncytium formation by plasma membrane fusion (GO:0000768)2.81695171
154regulation of calcium ion transmembrane transport (GO:1903169)2.78875943
155regulation of calcium ion transmembrane transporter activity (GO:1901019)2.78875943
156muscle fiber development (GO:0048747)2.72055033
157striated muscle adaptation (GO:0014888)2.71756268
158NADH metabolic process (GO:0006734)2.67913001
159skeletal muscle tissue development (GO:0007519)2.67319190
160striated muscle hypertrophy (GO:0014897)2.67126555
161negative regulation of skeletal muscle tissue development (GO:0048642)2.64698294
162stress fiber assembly (GO:0043149)2.62616461
163cell communication by electrical coupling (GO:0010644)2.62179674
164negative regulation of necroptotic process (GO:0060546)2.61922719
165glycogen catabolic process (GO:0005980)2.60521989
166response to epinephrine (GO:0071871)2.53814734
167regulation of the force of heart contraction (GO:0002026)2.53170290
168regulation of early endosome to late endosome transport (GO:2000641)2.47417888
169insulin-like growth factor receptor signaling pathway (GO:0048009)2.46421370
170negative regulation of inclusion body assembly (GO:0090084)2.43456759
171protein localization to endosome (GO:0036010)2.40152411
172regulation of striated muscle contraction (GO:0006942)2.39194750
173striated muscle atrophy (GO:0014891)2.38958151
174phosphorelay signal transduction system (GO:0000160)2.37925708
175regulation of synapse maturation (GO:0090128)2.37475356
176cardiac muscle adaptation (GO:0014887)2.36131083
177cardiac muscle hypertrophy in response to stress (GO:0014898)2.36131083
178muscle hypertrophy in response to stress (GO:0003299)2.36131083
179myelination in peripheral nervous system (GO:0022011)2.34560724
180peripheral nervous system axon ensheathment (GO:0032292)2.34560724
181muscle organ development (GO:0007517)2.34377773
182negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34116171
183glucan catabolic process (GO:0009251)2.33856617
184muscle hypertrophy (GO:0014896)2.32226531
185muscle adaptation (GO:0043500)2.31747960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.56579493
2GBX2_23144817_ChIP-Seq_PC3_Human3.17524010
3REST_21632747_ChIP-Seq_MESCs_Mouse2.71546329
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.65825572
5THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.64360172
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.62987982
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.59723301
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50417613
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.45867878
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.45486715
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44212353
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30248764
13LXR_22292898_ChIP-Seq_THP-1_Human2.28978305
14DROSHA_22980978_ChIP-Seq_HELA_Human2.23320716
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22933401
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.20905209
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.20679390
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17395224
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17395224
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16172977
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.13527187
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04769657
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.01961124
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.00224416
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97001773
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.94937145
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93466278
28* RNF2_27304074_Chip-Seq_ESCs_Mouse1.92774671
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86802691
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86569619
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.86423874
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85614722
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.83134548
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78912049
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.78163462
36BP1_19119308_ChIP-ChIP_Hs578T_Human1.77227581
37* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75188342
38KDM2B_26808549_Chip-Seq_DND41_Human1.74338437
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74149697
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74023135
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.70652830
42* TBX20_22328084_ChIP-Seq_HEART_Mouse1.70381724
43* TBX20_22080862_ChIP-Seq_HEART_Mouse1.70381724
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.69166842
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64007152
46SMAD4_21799915_ChIP-Seq_A2780_Human1.58920157
47TAF15_26573619_Chip-Seq_HEK293_Human1.57876017
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57851242
49CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57599573
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.55426683
51TCF7_22412390_ChIP-Seq_EML_Mouse1.55175085
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.55007842
53P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53525538
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.52558925
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48602668
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48195527
57AR_21572438_ChIP-Seq_LNCaP_Human1.48092973
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47227270
59* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46138417
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45543876
61CTCF_27219007_Chip-Seq_Bcells_Human1.43828120
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43431931
63RACK7_27058665_Chip-Seq_MCF-7_Human1.42736697
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.42472229
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41785929
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.39552349
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39436646
68ZNF274_21170338_ChIP-Seq_K562_Hela1.38655448
69VDR_21846776_ChIP-Seq_THP-1_Human1.38369668
70TP53_23651856_ChIP-Seq_MEFs_Mouse1.38352238
71* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36310375
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35173414
73RNF2_27304074_Chip-Seq_NSC_Mouse1.34391436
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33771361
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33295823
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32094576
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31731531
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.31585249
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30164634
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.29643250
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29418152
82* STAT3_23295773_ChIP-Seq_U87_Human1.27835131
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27407229
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26637498
85SMC4_20622854_ChIP-Seq_HELA_Human1.26571150
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24632616
87ZFP281_27345836_Chip-Seq_ESCs_Mouse1.22494254
88P300_19829295_ChIP-Seq_ESCs_Human1.20934991
89AR_25329375_ChIP-Seq_VCAP_Human1.19408720
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19230545
91GATA1_19941826_ChIP-Seq_K562_Human1.17876514
92* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17335918
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.16624728
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16436123
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.16395088
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.14994506
97CREB1_26743006_Chip-Seq_LNCaP_Human1.14670693
98* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14414795
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14065102
100NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13219673
101* TCF4_23295773_ChIP-Seq_U87_Human1.13000767
102GATA1_26923725_Chip-Seq_HPCs_Mouse1.11991134
103* EP300_21415370_ChIP-Seq_HL-1_Mouse1.11940791
104SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11565694
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11480720
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11113391
107P68_20966046_ChIP-Seq_HELA_Human1.09624044
108RING1B_27294783_Chip-Seq_ESCs_Mouse1.09596826
109AR_19668381_ChIP-Seq_PC3_Human1.09588678
110TP53_20018659_ChIP-ChIP_R1E_Mouse1.09512180
111CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09376187
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09143553
113VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.09126162
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09117622
115TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08662480
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08174106
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.08022394
118WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07896046
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07629378
120VDR_22108803_ChIP-Seq_LS180_Human1.07625485
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07253303
122MYC_22102868_ChIP-Seq_BL_Human1.07198325
123SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06391412
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06103160
125TP63_22573176_ChIP-Seq_HFKS_Human1.05238440
126SA1_27219007_Chip-Seq_ERYTHROID_Human1.05206252
127KDM2B_26808549_Chip-Seq_REH_Human1.05101571
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.04575485
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.04429366
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03719216
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03168450
132* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02874785
133TRIM28_21343339_ChIP-Seq_HEK293_Human1.02768591
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02432569
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01685171
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01665184
137CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00844056
138* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00348642
139GATA2_21666600_ChIP-Seq_HMVEC_Human1.00324696
140P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00201871
141ZNF263_19887448_ChIP-Seq_K562_Human0.99241368
142ELK4_26923725_Chip-Seq_MESODERM_Mouse0.98660956
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98375167
144* SMAD3_21741376_ChIP-Seq_ESCs_Human0.98006392
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.97876243
146POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97506768
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97506768
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97265541
149KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97209015
150OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96179332
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95142198
152FLI1_27457419_Chip-Seq_LIVER_Mouse0.94960558
153IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94439174
154CBP_20019798_ChIP-Seq_JUKART_Human0.94439174
155BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94354186
156PRDM14_20953172_ChIP-Seq_ESCs_Human0.94201350
157GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94142739
158* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93407511
159UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92926049
160POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92608800
161RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91774118
162TET1_21490601_ChIP-Seq_MESCs_Mouse0.91751513
163KDM2B_26808549_Chip-Seq_K562_Human0.90469553
164ARNT_22903824_ChIP-Seq_MCF-7_Human0.90130661
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.90063344
166* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89741183
167* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87502671
168WDR5_24793694_ChIP-Seq_LNCAP_Human0.87021012
169FUS_26573619_Chip-Seq_HEK293_Human0.86522672
170RUNX2_22187159_ChIP-Seq_PCA_Human0.86161398
171CDX2_19796622_ChIP-Seq_MESCs_Mouse0.85789586

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.81792535
2MP0003880_abnormal_central_pattern4.60120885
3MP0000749_muscle_degeneration4.22656601
4MP0003635_abnormal_synaptic_transmissio4.10890167
5MP0004270_analgesia3.66902509
6MP0009745_abnormal_behavioral_response3.33929234
7MP0002063_abnormal_learning/memory/cond3.31468164
8MP0005451_abnormal_body_composition3.30073636
9MP0009046_muscle_twitch3.27200608
10MP0000747_muscle_weakness3.16392838
11MP0002822_catalepsy3.16004637
12MP0005410_abnormal_fertilization3.08544062
13MP0002064_seizures3.00086979
14MP0000759_abnormal_skeletal_muscle2.94977356
15MP0001968_abnormal_touch/_nociception2.86846711
16MP0002572_abnormal_emotion/affect_behav2.78293846
17MP0003705_abnormal_hypodermis_morpholog2.75070556
18MP0004087_abnormal_muscle_fiber2.74877185
19MP0001986_abnormal_taste_sensitivity2.52942289
20MP0004084_abnormal_cardiac_muscle2.49389835
21MP0000733_abnormal_muscle_development2.47238538
22MP0002272_abnormal_nervous_system2.46566601
23MP0004130_abnormal_muscle_cell2.42728053
24MP0002734_abnormal_mechanical_nocicepti2.42531642
25MP0002106_abnormal_muscle_physiology2.35749823
26MP0001486_abnormal_startle_reflex2.35399590
27MP0002736_abnormal_nociception_after2.31400988
28MP0002269_muscular_atrophy2.31156333
29MP0001501_abnormal_sleep_pattern2.29010329
30MP0003646_muscle_fatigue2.27768938
31MP0005423_abnormal_somatic_nervous2.22976748
32MP0002332_abnormal_exercise_endurance2.19441400
33MP0001348_abnormal_lacrimal_gland2.15768894
34MP0003787_abnormal_imprinting2.07652341
35MP0005646_abnormal_pituitary_gland1.99454936
36MP0005369_muscle_phenotype1.95696261
37MP0001440_abnormal_grooming_behavior1.95444273
38MP0000750_abnormal_muscle_regeneration1.92405682
39MP0008877_abnormal_DNA_methylation1.91915803
40MP0005330_cardiomyopathy1.90216463
41MP0003950_abnormal_plasma_membrane1.87244990
42MP0005620_abnormal_muscle_contractility1.86910851
43MP0003329_amyloid_beta_deposits1.81376444
44MP0002733_abnormal_thermal_nociception1.75716466
45MP0001970_abnormal_pain_threshold1.75105176
46MP0002067_abnormal_sensory_capabilities1.72827176
47MP0003879_abnormal_hair_cell1.72112506
48MP0008569_lethality_at_weaning1.69921605
49MP0002735_abnormal_chemical_nociception1.68382506
50MP0001984_abnormal_olfaction1.67963895
51MP0004811_abnormal_neuron_physiology1.67777968
52MP0009780_abnormal_chondrocyte_physiolo1.65903052
53MP0005386_behavior/neurological_phenoty1.63805000
54MP0004924_abnormal_behavior1.63805000
55MP0002653_abnormal_ependyma_morphology1.54345855
56MP0001529_abnormal_vocalization1.52711160
57MP0002184_abnormal_innervation1.51179795
58MP0002909_abnormal_adrenal_gland1.50816945
59MP0002557_abnormal_social/conspecific_i1.49914803
60MP0005409_darkened_coat_color1.47809103
61MP0003698_abnormal_male_reproductive1.47219218
62MP0005670_abnormal_white_adipose1.45743837
63MP0004185_abnormal_adipocyte_glucose1.45014309
64MP0001905_abnormal_dopamine_level1.41872379
65MP0004233_abnormal_muscle_weight1.41525043
66MP0002972_abnormal_cardiac_muscle1.36536489
67MP0000955_abnormal_spinal_cord1.36057855
68MP0006276_abnormal_autonomic_nervous1.34303063
69MP0002882_abnormal_neuron_morphology1.33469856
70MP0002066_abnormal_motor_capabilities/c1.32766525
71MP0000778_abnormal_nervous_system1.31953062
72MP0008438_abnormal_cutaneous_collagen1.31450765
73MP0005551_abnormal_eye_electrophysiolog1.28871549
74MP0005666_abnormal_adipose_tissue1.28788912
75MP0001929_abnormal_gametogenesis1.27868834
76MP0004858_abnormal_nervous_system1.24501062
77MP0000003_abnormal_adipose_tissue1.21686108
78MP0001502_abnormal_circadian_rhythm1.21113191
79MP0002108_abnormal_muscle_morphology1.20329647
80MP0005375_adipose_tissue_phenotype1.19515374
81MP0003656_abnormal_erythrocyte_physiolo1.19479482
82MP0003633_abnormal_nervous_system1.19184287
83MP0000751_myopathy1.17913636
84MP0010630_abnormal_cardiac_muscle1.16296398
85MP0002877_abnormal_melanocyte_morpholog1.15654661
86MP0006138_congestive_heart_failure1.15183419
87MP0004145_abnormal_muscle_electrophysio1.13892220
88MP0004885_abnormal_endolymph1.06476367
89MP0002152_abnormal_brain_morphology1.05411276
90MP0003631_nervous_system_phenotype1.05253096
91MP0005076_abnormal_cell_differentiation1.02191988
92MP0005623_abnormal_meninges_morphology1.00044944
93MP0002161_abnormal_fertility/fecundity0.99973840
94MP0010368_abnormal_lymphatic_system0.99512270
95MP0003045_fibrosis0.98219438
96MP0004142_abnormal_muscle_tone0.97136114
97MP0002837_dystrophic_cardiac_calcinosis0.96152445
98MP0008872_abnormal_physiological_respon0.94344559
99MP0002229_neurodegeneration0.93897473
100MP0003690_abnormal_glial_cell0.93253206
101MP0000920_abnormal_myelination0.93177172
102MP0003091_abnormal_cell_migration0.93149305
103MP0008874_decreased_physiological_sensi0.91815432
104MP0001299_abnormal_eye_distance/0.91472510
105MP0002971_abnormal_brown_adipose0.90128776
106MP0000569_abnormal_digit_pigmentation0.89887418
107MP0001849_ear_inflammation0.88363561
108MP0002127_abnormal_cardiovascular_syste0.88176157
109MP0005645_abnormal_hypothalamus_physiol0.86791577
110MP0010386_abnormal_urinary_bladder0.86379632
111MP0001958_emphysema0.86298849
112MP0005058_abnormal_lysosome_morphology0.83482971
113MP0003075_altered_response_to0.82136786
114MP0003566_abnormal_cell_adhesion0.81861188
115MP0004085_abnormal_heartbeat0.80929120
116MP0004484_altered_response_of0.79901145
117MP0003122_maternal_imprinting0.79779407
118MP0002069_abnormal_eating/drinking_beha0.79063334
119MP0003221_abnormal_cardiomyocyte_apopto0.76888519
120MP0008961_abnormal_basal_metabolism0.76236325
121MP0003123_paternal_imprinting0.75176998
122MP0004510_myositis0.74592128
123MP0009840_abnormal_foam_cell0.74327224
124MP0002752_abnormal_somatic_nervous0.74268116
125MP0000631_abnormal_neuroendocrine_gland0.72771937
126MP0001177_atelectasis0.71053704
127MP0004215_abnormal_myocardial_fiber0.70469991
128MP0000534_abnormal_ureter_morphology0.69916519
129MP0002896_abnormal_bone_mineralization0.69047285
130MP0000604_amyloidosis0.68475062
131MP0001963_abnormal_hearing_physiology0.68321293
132MP0003632_abnormal_nervous_system0.68319243
133MP0000013_abnormal_adipose_tissue0.68057064
134MP0002210_abnormal_sex_determination0.68019174
135MP0008260_abnormal_autophagy0.67665096
136MP0003828_pulmonary_edema0.67211977
137MP0004036_abnormal_muscle_relaxation0.66371076
138MP0002102_abnormal_ear_morphology0.66152576
139MP0001661_extended_life_span0.65429438
140MP0006072_abnormal_retinal_apoptosis0.65210644
141MP0000653_abnormal_sex_gland0.64691544
142MP0005535_abnormal_body_temperature0.63290867
143MP0000762_abnormal_tongue_morphology0.61256895
144MP0004742_abnormal_vestibular_system0.60639122
145MP0001544_abnormal_cardiovascular_syste0.59847428
146MP0005385_cardiovascular_system_phenoty0.59847428
147MP0003121_genomic_imprinting0.58402776
148MP0005394_taste/olfaction_phenotype0.58055086
149MP0005499_abnormal_olfactory_system0.58055086
150MP0004134_abnormal_chest_morphology0.57101347
151MP0001765_abnormal_ion_homeostasis0.57056283
152MP0003861_abnormal_nervous_system0.56855393
153MP0005257_abnormal_intraocular_pressure0.56845872
154MP0003634_abnormal_glial_cell0.56286057
155MP0002638_abnormal_pupillary_reflex0.55127962
156MP0010234_abnormal_vibrissa_follicle0.52665463
157MP0005187_abnormal_penis_morphology0.51978350
158MP0003191_abnormal_cellular_cholesterol0.51777074

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.75635332
2Nemaline bodies (HP:0003798)7.61494617
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.58846822
4Focal motor seizures (HP:0011153)6.84836020
5Type 1 muscle fiber predominance (HP:0003803)6.83719360
6Myokymia (HP:0002411)6.81083496
7Exercise-induced myalgia (HP:0003738)6.27536468
8Focal seizures (HP:0007359)5.06799198
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.99763790
10Round ear (HP:0100830)4.65110895
11Distal arthrogryposis (HP:0005684)4.39250892
12Exercise-induced muscle cramps (HP:0003710)4.38433951
13Epileptic encephalopathy (HP:0200134)4.37691553
14Increased connective tissue (HP:0009025)4.32756603
15Atonic seizures (HP:0010819)4.25438794
16Absent/shortened dynein arms (HP:0200106)4.24884357
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.24884357
18Myopathic facies (HP:0002058)4.18152076
19Hyporeflexia of lower limbs (HP:0002600)4.16187896
20EMG: myopathic abnormalities (HP:0003458)4.15716065
21Visual hallucinations (HP:0002367)4.15551434
22Centrally nucleated skeletal muscle fibers (HP:0003687)4.15417710
23Progressive cerebellar ataxia (HP:0002073)3.96168411
24Febrile seizures (HP:0002373)3.88893430
25Abnormality of skeletal muscle fiber size (HP:0012084)3.85055619
26Muscle hypertrophy of the lower extremities (HP:0008968)3.72517962
27Ulnar deviation of the wrist (HP:0003049)3.72272657
28Abnormal respiratory motile cilium physiology (HP:0012261)3.68468847
29Increased variability in muscle fiber diameter (HP:0003557)3.62497433
30Impaired vibration sensation in the lower limbs (HP:0002166)3.58189379
31Abnormality of the calf musculature (HP:0001430)3.55108806
32Muscle fiber splitting (HP:0003555)3.54380128
33Absence seizures (HP:0002121)3.51379101
34Asymmetric septal hypertrophy (HP:0001670)3.51303199
35Distal lower limb muscle weakness (HP:0009053)3.46390181
36Distal lower limb amyotrophy (HP:0008944)3.44099639
37Action tremor (HP:0002345)3.41779088
38Generalized tonic-clonic seizures (HP:0002069)3.39194933
39Gaze-evoked nystagmus (HP:0000640)3.36132923
40Myoglobinuria (HP:0002913)3.36082613
41Calf muscle hypertrophy (HP:0008981)3.35279709
42Subaortic stenosis (HP:0001682)3.33333705
43Abnormality of the left ventricular outflow tract (HP:0011103)3.33333705
44Neck muscle weakness (HP:0000467)3.30118873
45Infertility (HP:0000789)3.27357074
46Rhabdomyolysis (HP:0003201)3.26028839
47Difficulty running (HP:0009046)3.25968722
48Mildly elevated creatine phosphokinase (HP:0008180)3.16222928
49Frequent falls (HP:0002359)3.10805890
50Dysdiadochokinesis (HP:0002075)3.10770398
51Urinary bladder sphincter dysfunction (HP:0002839)3.09526764
52Dialeptic seizures (HP:0011146)3.09000626
53Abnormal ciliary motility (HP:0012262)3.07637817
54Abnormality of the lower motor neuron (HP:0002366)3.03503145
55Rhinitis (HP:0012384)3.02802659
56Spinal rigidity (HP:0003306)2.97541965
57Dysmetria (HP:0001310)2.96502667
58Broad-based gait (HP:0002136)2.94851875
59Impaired smooth pursuit (HP:0007772)2.92032344
60Male infertility (HP:0003251)2.87432189
61Calcaneovalgus deformity (HP:0001848)2.83823730
62Sudden death (HP:0001699)2.82820697
63Scapular winging (HP:0003691)2.79555541
64Supranuclear gaze palsy (HP:0000605)2.76684693
65Depression (HP:0000716)2.76656068
66Muscle stiffness (HP:0003552)2.76648561
67Truncal ataxia (HP:0002078)2.76481445
68Dysmetric saccades (HP:0000641)2.76368360
69Poor eye contact (HP:0000817)2.75110137
70Ankle clonus (HP:0011448)2.72348673
71Abnormal eating behavior (HP:0100738)2.69320525
72Abnormal respiratory epithelium morphology (HP:0012253)2.68769924
73Abnormal respiratory motile cilium morphology (HP:0005938)2.68769924
74Genetic anticipation (HP:0003743)2.66590013
75Myotonia (HP:0002486)2.65252987
76Postural instability (HP:0002172)2.62473916
77Urinary urgency (HP:0000012)2.61677207
78Amblyopia (HP:0000646)2.61519995
79Abnormality of ocular smooth pursuit (HP:0000617)2.60849038
80EMG: neuropathic changes (HP:0003445)2.58689480
81Impaired vibratory sensation (HP:0002495)2.54462338
82Fetal akinesia sequence (HP:0001989)2.52416762
83Deformed tarsal bones (HP:0008119)2.48713060
84Slender build (HP:0001533)2.48135714
85Torticollis (HP:0000473)2.47768933
86Papilledema (HP:0001085)2.46439575
87Rimmed vacuoles (HP:0003805)2.44910587
88Abnormal social behavior (HP:0012433)2.44097708
89Impaired social interactions (HP:0000735)2.44097708
90Difficulty climbing stairs (HP:0003551)2.43984112
91Bulbar palsy (HP:0001283)2.41458200
92Ventricular tachycardia (HP:0004756)2.41382705
93Anxiety (HP:0000739)2.41184202
94Malignant hyperthermia (HP:0002047)2.35668870
95Mutism (HP:0002300)2.34257158
96Absent phalangeal crease (HP:0006109)2.33927376
97Spastic gait (HP:0002064)2.31915391
98Progressive inability to walk (HP:0002505)2.31459807
99Annular pancreas (HP:0001734)2.30544529
100Ventricular fibrillation (HP:0001663)2.29588693
101Termporal pattern (HP:0011008)2.28736806
102Insidious onset (HP:0003587)2.28736806
103Hyperventilation (HP:0002883)2.28116035
104Foot dorsiflexor weakness (HP:0009027)2.26887772
105Focal dystonia (HP:0004373)2.26125805
106Abnormality of saccadic eye movements (HP:0000570)2.26103278
107Chronic bronchitis (HP:0004469)2.25432273
108Achilles tendon contracture (HP:0001771)2.24116272
109Bundle branch block (HP:0011710)2.22108819
110Abnormal atrioventricular conduction (HP:0005150)2.14395733
111Hyperkalemia (HP:0002153)2.14338322
112Abnormality of the foot musculature (HP:0001436)2.13523922
113Ragged-red muscle fibers (HP:0003200)2.13399851
114Gait imbalance (HP:0002141)2.11264339
115Stereotypic behavior (HP:0000733)2.08555516
116Medial flaring of the eyebrow (HP:0010747)2.08208276
117Obstructive sleep apnea (HP:0002870)2.07079378
118Protrusio acetabuli (HP:0003179)2.04776290
119Bradykinesia (HP:0002067)2.04068560
120Epileptiform EEG discharges (HP:0011182)2.03725283
121Absent speech (HP:0001344)2.03576005
122Generalized muscle weakness (HP:0003324)2.03270105
123Heart block (HP:0012722)2.02285478
124Drooling (HP:0002307)2.02203186
125Excessive salivation (HP:0003781)2.02203186
126Limb-girdle muscle atrophy (HP:0003797)2.01443473
127Pointed chin (HP:0000307)2.00516061
128Hemiparesis (HP:0001269)1.99638856
129Craniofacial dystonia (HP:0012179)1.99624903
130Lower limb muscle weakness (HP:0007340)1.98714667
131Inability to walk (HP:0002540)1.96452541
132Cerebral inclusion bodies (HP:0100314)1.95845554
133Intention tremor (HP:0002080)1.95727433
134Abnormality of the calcaneus (HP:0008364)1.94769392
135Gait ataxia (HP:0002066)1.93625258
136Reduced subcutaneous adipose tissue (HP:0003758)1.93012573
137Scanning speech (HP:0002168)1.92713922
138Abnormality of the Achilles tendon (HP:0005109)1.92021666
139Neurofibrillary tangles (HP:0002185)1.91415606
140Areflexia of lower limbs (HP:0002522)1.90580203
141Abnormality of the corticospinal tract (HP:0002492)1.89679661
142Congenital primary aphakia (HP:0007707)1.88891659
143EEG with generalized epileptiform discharges (HP:0011198)1.88391045
144Status epilepticus (HP:0002133)1.87437549
145Hyperacusis (HP:0010780)1.87233367
146Abnormality of binocular vision (HP:0011514)1.86772573
147Diplopia (HP:0000651)1.86772573
148Abnormal finger flexion creases (HP:0006143)1.85850862
149Generalized amyotrophy (HP:0003700)1.84291572
150Metatarsus adductus (HP:0001840)1.82421631
151Delusions (HP:0000746)1.81324108
152Nephronophthisis (HP:0000090)1.81061896
153Atrophic scars (HP:0001075)1.78765236
154Hypsarrhythmia (HP:0002521)1.78507426
155Hypercortisolism (HP:0001578)1.77991655
156Dilated cardiomyopathy (HP:0001644)1.77695257
157Insomnia (HP:0100785)1.77173176
158Decreased motor nerve conduction velocity (HP:0003431)1.77150935
159Atrioventricular block (HP:0001678)1.76891878
160Generalized myoclonic seizures (HP:0002123)1.76476261
161Incomplete penetrance (HP:0003829)1.75751270
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.75741507
163Lower limb amyotrophy (HP:0007210)1.75261048
164Resting tremor (HP:0002322)1.74832394
165Anosmia (HP:0000458)1.74642664
166Amyotrophic lateral sclerosis (HP:0007354)1.72076898
167Polyphagia (HP:0002591)1.72043847
168Neuronal loss in central nervous system (HP:0002529)1.71807354
169Progressive muscle weakness (HP:0003323)1.71419972
170Gowers sign (HP:0003391)1.71216635
171Molar tooth sign on MRI (HP:0002419)1.71157114
172Abnormality of midbrain morphology (HP:0002418)1.71157114
173Abnormal gallbladder physiology (HP:0012438)1.71028513
174Lipoatrophy (HP:0100578)1.67342232
175Abnormality of the neuromuscular junction (HP:0003398)1.66945828
176Fatigable weakness (HP:0003473)1.66945828
177Hip contracture (HP:0003273)1.66514694
178Waddling gait (HP:0002515)1.66051138
179Rapidly progressive (HP:0003678)1.65365730
180Stridor (HP:0010307)1.64943096
181Aortic aneurysm (HP:0004942)1.63978433
182Bowel incontinence (HP:0002607)1.62635951
183Limb-girdle muscle weakness (HP:0003325)1.62424878
184Abnormality of the shoulder girdle musculature (HP:0001435)1.59272474
185Cerebral aneurysm (HP:0004944)1.58607242
186Reticulocytosis (HP:0001923)1.54998972

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.03566804
2EPHA44.39944118
3NTRK34.19793039
4MAP3K93.98911541
5TTN3.85919482
6PRKD33.56395944
7MAP3K43.14307182
8TRIB32.79263372
9KSR22.75398112
10MAP2K72.55499929
11MINK12.34002400
12PAK62.22885469
13DAPK22.13402078
14NTRK21.90188836
15KSR11.90002599
16PDK41.87160514
17PDK31.87160514
18RIPK11.83093182
19STK381.80252134
20ARAF1.79902231
21MAP3K131.77661666
22RIPK41.77349826
23MAP2K41.71132986
24CAMKK11.68098850
25TAOK11.67285653
26NTRK11.64982931
27MARK11.64279209
28MAP2K31.56923856
29MAPK121.56464676
30IRAK31.51511831
31MAP3K121.46081979
32PTK2B1.42611546
33DDR21.41860018
34LATS21.39519958
35TYRO31.39054975
36DAPK11.37797922
37CDK51.33123235
38SIK11.31782571
39PDGFRA1.31584073
40PIM21.29927603
41PLK21.28325974
42BMPR21.21814221
43RAF11.21752625
44PIK3CG1.21014122
45MAPK131.20880144
46PRPF4B1.20287027
47NEK91.20265980
48SIK21.18376214
49CDK121.15448650
50MAP3K61.14587466
51FES1.13939407
52PNCK1.13656829
53BRAF1.09832611
54PRKCG1.08242506
55CDK191.06768037
56MOS1.03459046
57GRK51.01502045
58PDK20.99977289
59CAMK1G0.98525029
60MAP3K20.97396268
61MET0.96800530
62MTOR0.95184000
63TAOK20.94454762
64CAMK2A0.94110032
65PDK10.94095957
66RET0.91246688
67CDK180.90661439
68MUSK0.89822465
69CDK150.87171337
70MAP3K30.84943621
71PRKCH0.83363307
72ERN10.82829839
73RPS6KA20.82779632
74STK110.81783178
75PINK10.81394459
76CASK0.81144419
77CDK140.80081075
78CDC42BPA0.78755833
79SGK2230.78668259
80SGK4940.78668259
81CAMK2G0.78409804
82PDPK10.76740555
83DYRK1B0.76207462
84MARK20.74696416
85CDK11A0.74610524
86MAPK70.72919982
87CAMK10.72915341
88LIMK10.72077303
89MAP3K10.71502363
90SGK20.71127720
91TRPM70.70908689
92TNIK0.69298680
93CAMK40.68454699
94MAP3K110.67030038
95EEF2K0.64887441
96MAPK40.64324973
97CAMK1D0.64094358
98INSRR0.61613240
99SGK30.61235719
100PTK20.59642938
101AKT20.59358859
102CAMKK20.59258577
103TESK10.59167480
104CCNB10.58373698
105MAPK110.56903268
106SGK10.56148437
107LMTK20.55874692
108ICK0.54706117
109UHMK10.53362385
110BRSK10.52885984
111CAMK2B0.51936305
112TGFBR20.50665798
113OXSR10.49189949
114MST1R0.48472817
115PRKG20.47662333
116PAK30.45524495
117MAPKAPK50.44176169
118DMPK0.44163956
119PRKAA10.44059968
120ROCK10.44049138
121PDGFRB0.43662887
122ABL20.43343597
123RPS6KA30.43127975
124RPS6KL10.42930974
125RPS6KC10.42930974
126WNK10.42678647
127PRKD20.42413597
128ERBB40.41657960
129PKN10.41286956
130ALK0.40860760
131SMG10.40682140
132MAP2K10.39975133
133TNK20.39932025
134NEK10.39676035
135MAPK100.39425185
136CSNK1G20.39399256
137WNK40.39098236
138PRKCZ0.39057153
139DYRK1A0.36913457
140PRKAA20.36574347
141ILK0.36027761
142MAP3K140.35939717
143SIK30.35790849
144PAK20.35366005
145DAPK30.34865360
146PHKG20.34750991
147PHKG10.34750991
148MAP2K20.34229330
149STK390.31909291
150NEK60.31213183
151MAP3K70.31021027
152TTK0.30124693

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.36882712
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27698855
3Olfactory transduction_Homo sapiens_hsa047403.04490413
4Long-term potentiation_Homo sapiens_hsa047202.74557718
5Amphetamine addiction_Homo sapiens_hsa050312.61387665
6Circadian entrainment_Homo sapiens_hsa047132.59946686
7Glutamatergic synapse_Homo sapiens_hsa047242.51354225
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45341702
9Morphine addiction_Homo sapiens_hsa050322.36563834
10GABAergic synapse_Homo sapiens_hsa047272.34526958
11Dopaminergic synapse_Homo sapiens_hsa047282.18290533
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11617184
13Salivary secretion_Homo sapiens_hsa049702.09086124
14Insulin secretion_Homo sapiens_hsa049111.93351535
15Cholinergic synapse_Homo sapiens_hsa047251.83518759
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82011059
17Gastric acid secretion_Homo sapiens_hsa049711.78550140
18Phototransduction_Homo sapiens_hsa047441.75410649
19Oxytocin signaling pathway_Homo sapiens_hsa049211.72919647
20Cocaine addiction_Homo sapiens_hsa050301.69183778
21Renin secretion_Homo sapiens_hsa049241.67750425
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66893029
23Long-term depression_Homo sapiens_hsa047301.64125428
24GnRH signaling pathway_Homo sapiens_hsa049121.57968457
25Calcium signaling pathway_Homo sapiens_hsa040201.57750699
26Taste transduction_Homo sapiens_hsa047421.56568042
27Serotonergic synapse_Homo sapiens_hsa047261.48655919
28Collecting duct acid secretion_Homo sapiens_hsa049661.46211921
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44192866
30Oocyte meiosis_Homo sapiens_hsa041141.40979917
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37231141
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33015735
33cAMP signaling pathway_Homo sapiens_hsa040241.31168757
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30852636
35Chronic myeloid leukemia_Homo sapiens_hsa052201.30686009
36Focal adhesion_Homo sapiens_hsa045101.28944536
37Glioma_Homo sapiens_hsa052141.26775398
38Estrogen signaling pathway_Homo sapiens_hsa049151.25386758
39Gap junction_Homo sapiens_hsa045401.24147787
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.19697016
41Dorso-ventral axis formation_Homo sapiens_hsa043201.13824065
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13516089
43AMPK signaling pathway_Homo sapiens_hsa041521.12419159
44Insulin resistance_Homo sapiens_hsa049311.11956870
45Fatty acid biosynthesis_Homo sapiens_hsa000611.11698561
46Type II diabetes mellitus_Homo sapiens_hsa049301.11207762
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09679965
48ErbB signaling pathway_Homo sapiens_hsa040121.03960011
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00283524
50Prion diseases_Homo sapiens_hsa050200.98437214
51Pentose phosphate pathway_Homo sapiens_hsa000300.98123740
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.96941920
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96270495
54Glucagon signaling pathway_Homo sapiens_hsa049220.92882928
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91315668
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.89129773
57Melanogenesis_Homo sapiens_hsa049160.88941409
58B cell receptor signaling pathway_Homo sapiens_hsa046620.88673920
59VEGF signaling pathway_Homo sapiens_hsa043700.87298816
60Cardiac muscle contraction_Homo sapiens_hsa042600.87108374
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86991634
62Proteoglycans in cancer_Homo sapiens_hsa052050.86423764
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86142279
64Choline metabolism in cancer_Homo sapiens_hsa052310.86074431
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.85208201
66Acute myeloid leukemia_Homo sapiens_hsa052210.84072368
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81322315
68Bladder cancer_Homo sapiens_hsa052190.79868293
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79546404
70Vibrio cholerae infection_Homo sapiens_hsa051100.79023204
71Circadian rhythm_Homo sapiens_hsa047100.77430644
72Axon guidance_Homo sapiens_hsa043600.77138169
73MAPK signaling pathway_Homo sapiens_hsa040100.76924271
74FoxO signaling pathway_Homo sapiens_hsa040680.76298604
75ECM-receptor interaction_Homo sapiens_hsa045120.76039967
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.75073090
77Pancreatic cancer_Homo sapiens_hsa052120.74585576
78Pancreatic secretion_Homo sapiens_hsa049720.74569053
79Ovarian steroidogenesis_Homo sapiens_hsa049130.72895018
80Arginine and proline metabolism_Homo sapiens_hsa003300.72893267
81mTOR signaling pathway_Homo sapiens_hsa041500.72784146
82Carbon metabolism_Homo sapiens_hsa012000.70813365
83Thyroid hormone synthesis_Homo sapiens_hsa049180.70535631
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70038892
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69880927
86Adherens junction_Homo sapiens_hsa045200.69247988
87Tight junction_Homo sapiens_hsa045300.69029936
88Dilated cardiomyopathy_Homo sapiens_hsa054140.68891950
89Inositol phosphate metabolism_Homo sapiens_hsa005620.68286555
90Biosynthesis of amino acids_Homo sapiens_hsa012300.67900691
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65837171
92Ras signaling pathway_Homo sapiens_hsa040140.63797424
93Amoebiasis_Homo sapiens_hsa051460.63786395
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.61355045
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60818516
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60266463
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58230272
98Non-small cell lung cancer_Homo sapiens_hsa052230.57084472
99Fructose and mannose metabolism_Homo sapiens_hsa000510.56587846
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55695511
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55462466
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55137696
103Platelet activation_Homo sapiens_hsa046110.55043126
104Alcoholism_Homo sapiens_hsa050340.54629079
105Endocytosis_Homo sapiens_hsa041440.54371120
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53759173
107Arginine biosynthesis_Homo sapiens_hsa002200.53595663
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.49986623
109Rap1 signaling pathway_Homo sapiens_hsa040150.49685944
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.47652410
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46695705
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45784787
113Nitrogen metabolism_Homo sapiens_hsa009100.45426596
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43659613
115Insulin signaling pathway_Homo sapiens_hsa049100.43438461
116Renal cell carcinoma_Homo sapiens_hsa052110.42698050
117Endometrial cancer_Homo sapiens_hsa052130.42465982
118Vitamin B6 metabolism_Homo sapiens_hsa007500.41115217
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40723295
120Type I diabetes mellitus_Homo sapiens_hsa049400.39745207
121Wnt signaling pathway_Homo sapiens_hsa043100.36368497
122Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35371448
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33314564
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32924388
125Prolactin signaling pathway_Homo sapiens_hsa049170.31765870
126Bile secretion_Homo sapiens_hsa049760.30778290
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.29989619
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29557164
129Colorectal cancer_Homo sapiens_hsa052100.27458920
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26499831
131Chemokine signaling pathway_Homo sapiens_hsa040620.26356397

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