TTLL12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.49376038
2embryonic process involved in female pregnancy (GO:0060136)5.80686744
3transcription from mitochondrial promoter (GO:0006390)5.72738694
4DNA deamination (GO:0045006)5.49235636
5proline metabolic process (GO:0006560)5.39899179
6replication fork processing (GO:0031297)5.38784079
7establishment of apical/basal cell polarity (GO:0035089)4.88630890
8formation of translation preinitiation complex (GO:0001731)4.87704520
9protein complex localization (GO:0031503)4.81413740
10maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.78275302
11regulation of translational fidelity (GO:0006450)4.77731050
12cellular protein complex localization (GO:0034629)4.76487320
13positive regulation of protein homooligomerization (GO:0032464)4.64923784
14mitotic chromosome condensation (GO:0007076)4.55078107
15regulation of integrin activation (GO:0033623)4.53988272
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.53609937
17somatic hypermutation of immunoglobulin genes (GO:0016446)4.53609937
18mitotic G1 DNA damage checkpoint (GO:0031571)4.52565609
19negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.47355130
20nuclear pore complex assembly (GO:0051292)4.39433092
21mitochondrial DNA metabolic process (GO:0032042)4.35018746
22telomere maintenance via semi-conservative replication (GO:0032201)4.33578070
23establishment of monopolar cell polarity (GO:0061162)4.18079901
24establishment or maintenance of monopolar cell polarity (GO:0061339)4.18079901
25DNA strand elongation involved in DNA replication (GO:0006271)4.15656695
26oxidative demethylation (GO:0070989)4.14661065
27regulation of protein homooligomerization (GO:0032462)4.08998531
28spliceosomal tri-snRNP complex assembly (GO:0000244)4.08756191
29DNA strand renaturation (GO:0000733)4.05934144
30viral mRNA export from host cell nucleus (GO:0046784)4.02526266
31G1 DNA damage checkpoint (GO:0044783)4.01196779
32negative regulation of mRNA processing (GO:0050686)3.96999595
33base-excision repair (GO:0006284)3.95479105
34mRNA cleavage (GO:0006379)3.91942418
35mitotic G1/S transition checkpoint (GO:0044819)3.90629341
36DNA strand elongation (GO:0022616)3.90242671
37dosage compensation (GO:0007549)3.87144530
38L-serine metabolic process (GO:0006563)3.85243483
39nuclear pore organization (GO:0006999)3.80770423
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.79595255
41positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79595255
42positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79595255
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.76892846
44negative regulation of cell cycle arrest (GO:0071157)3.72932955
45negative regulation of RNA splicing (GO:0033119)3.72718429
46regulation of sister chromatid cohesion (GO:0007063)3.72547623
47ribosomal small subunit biogenesis (GO:0042274)3.62354472
48regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59653734
49protein localization to chromosome, centromeric region (GO:0071459)3.59035519
50mitotic sister chromatid segregation (GO:0000070)3.57217985
51DNA unwinding involved in DNA replication (GO:0006268)3.56491636
52telomere maintenance via recombination (GO:0000722)3.56318299
53termination of RNA polymerase II transcription (GO:0006369)3.55626071
54positive regulation of chromosome segregation (GO:0051984)3.51468579
55DNA topological change (GO:0006265)3.50444070
56RNA stabilization (GO:0043489)3.47268363
57mRNA stabilization (GO:0048255)3.47268363
583-UTR-mediated mRNA stabilization (GO:0070935)3.46180354
59negative regulation of JAK-STAT cascade (GO:0046426)3.43772641
60regulation of posttranscriptional gene silencing (GO:0060147)3.43010094
61regulation of gene silencing by miRNA (GO:0060964)3.43010094
62regulation of gene silencing by RNA (GO:0060966)3.43010094
63poly(A)+ mRNA export from nucleus (GO:0016973)3.42752086
64regulation of translational termination (GO:0006449)3.42519648
65histone H4-K12 acetylation (GO:0043983)3.41069993
66meiotic chromosome segregation (GO:0045132)3.40093520
67negative regulation of mRNA metabolic process (GO:1903312)3.38585226
68establishment of integrated proviral latency (GO:0075713)3.38438813
69mitotic nuclear envelope disassembly (GO:0007077)3.36828126
70regulation of RNA export from nucleus (GO:0046831)3.35301473
71trophectodermal cell differentiation (GO:0001829)3.33794296
72nucleosome disassembly (GO:0006337)3.30712812
73protein-DNA complex disassembly (GO:0032986)3.30712812
74positive regulation of DNA-dependent DNA replication (GO:2000105)3.28461702
75rRNA transcription (GO:0009303)3.25078728
76maturation of 5.8S rRNA (GO:0000460)3.24889918
77apoptotic process involved in morphogenesis (GO:0060561)3.23615675
78folic acid metabolic process (GO:0046655)3.21986653
79pore complex assembly (GO:0046931)3.21959332
80kinetochore assembly (GO:0051382)3.21780752
81IMP biosynthetic process (GO:0006188)3.21479919
82mitotic recombination (GO:0006312)3.20706767
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.19695237
84non-recombinational repair (GO:0000726)3.19169293
85double-strand break repair via nonhomologous end joining (GO:0006303)3.19169293
86embryonic placenta development (GO:0001892)3.18776912
87sister chromatid segregation (GO:0000819)3.17153334
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.16893356
89telomere maintenance via telomere lengthening (GO:0010833)3.16454628
90regulation of DNA damage checkpoint (GO:2000001)3.16346064
91heterochromatin organization (GO:0070828)3.13818537
92mitochondrial RNA metabolic process (GO:0000959)3.13600503
93pentose-phosphate shunt (GO:0006098)3.13260613
94chromatin assembly (GO:0031497)3.12938443
95positive regulation by host of viral transcription (GO:0043923)3.12399112
96nuclear envelope reassembly (GO:0031468)3.12037619
97mitotic nuclear envelope reassembly (GO:0007084)3.12037619
98pre-miRNA processing (GO:0031054)3.11943690
99ribosomal small subunit assembly (GO:0000028)3.11158018
100nuclear envelope disassembly (GO:0051081)3.11027773
101membrane disassembly (GO:0030397)3.11027773
102regulation of double-strand break repair (GO:2000779)3.10580619
103COPI coating of Golgi vesicle (GO:0048205)3.09472093
104Golgi transport vesicle coating (GO:0048200)3.09472093
105negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.09239405
106peptidyl-arginine methylation (GO:0018216)3.08328437
107peptidyl-arginine N-methylation (GO:0035246)3.08328437
108kinetochore organization (GO:0051383)3.07168718
109folic acid-containing compound biosynthetic process (GO:0009396)3.07153256
110nodal signaling pathway (GO:0038092)3.06593623
111DNA double-strand break processing (GO:0000729)3.05487142
112ribonucleoprotein complex biogenesis (GO:0022613)3.05486405
113planar cell polarity pathway involved in neural tube closure (GO:0090179)3.03980935
114nucleobase-containing small molecule interconversion (GO:0015949)3.03658623
115positive regulation of protein oligomerization (GO:0032461)3.03193858
116embryonic camera-type eye development (GO:0031076)3.02458855
117histone arginine methylation (GO:0034969)3.01635056
118maturation of SSU-rRNA (GO:0030490)3.00076163
119ribosomal large subunit biogenesis (GO:0042273)2.98401494
120mitotic sister chromatid cohesion (GO:0007064)2.97985775
121negative regulation of cell size (GO:0045792)2.97223785
122mitotic metaphase plate congression (GO:0007080)2.95666963
123DNA replication initiation (GO:0006270)2.94303261
124peptidyl-arginine omega-N-methylation (GO:0035247)2.94036134
125base-excision repair, AP site formation (GO:0006285)2.93423160
126DNA integration (GO:0015074)2.93398122
127pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92672996
128protein export from nucleus (GO:0006611)2.92588413
129protein localization to kinetochore (GO:0034501)2.92259195
130DNA duplex unwinding (GO:0032508)2.89380844
131nucleobase biosynthetic process (GO:0046112)2.88975093
132IMP metabolic process (GO:0046040)2.87487051
133DNA conformation change (GO:0071103)2.87333456
134DNA geometric change (GO:0032392)2.86563786
135NADPH regeneration (GO:0006740)2.86269958
136mRNA export from nucleus (GO:0006406)2.82412395
137ribosome biogenesis (GO:0042254)2.81115891
138pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80909707
139serine family amino acid biosynthetic process (GO:0009070)2.80461919
140regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.80444609
141nuclear envelope organization (GO:0006998)2.79224055
142regulation of hippo signaling (GO:0035330)2.78804311
143translational initiation (GO:0006413)2.78618026
144mRNA transport (GO:0051028)2.77404781
145chromosome condensation (GO:0030261)2.77300163
146pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.76555605
147pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.76189511
148ncRNA 3-end processing (GO:0043628)2.75751689
149glucose catabolic process (GO:0006007)2.73442731
150DNA synthesis involved in DNA repair (GO:0000731)2.72253995
151regulation of translational elongation (GO:0006448)2.70945726
152DNA replication checkpoint (GO:0000076)2.69796353
153activation of Rac GTPase activity (GO:0032863)2.69271243
154pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.69239999
155urea cycle (GO:0000050)2.68664573
156regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.68269144
157ribosome assembly (GO:0042255)2.66902941
158regulation of mitochondrial translation (GO:0070129)2.64629014
159purine nucleobase biosynthetic process (GO:0009113)2.61652691
160regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59920874
161adenine nucleotide transport (GO:0051503)2.59505308
162maternal placenta development (GO:0001893)2.59266152
163chromatin assembly or disassembly (GO:0006333)2.58174627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.58460037
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.60089110
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44729348
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36228973
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74326903
6SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.55614268
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.52714889
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39066507
9MYC_22102868_ChIP-Seq_BL_Human2.36684448
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35071433
11VDR_21846776_ChIP-Seq_THP-1_Human2.28788882
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26817383
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24652491
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.06346848
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.06346848
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.06346848
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.04822955
18KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.91883832
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78384476
20STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76981708
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75245990
22XRN2_22483619_ChIP-Seq_HELA_Human1.73942889
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.70009341
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.69157611
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.66848864
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.64407993
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64133733
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61293171
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61054244
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60388297
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56993228
32KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56992182
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56836504
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56483534
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56369146
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55640048
37NANOG_21062744_ChIP-ChIP_HESCs_Human1.52942590
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52535614
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.52293692
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.50427566
41NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50420357
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.48363845
43LXR_22292898_ChIP-Seq_THP-1_Human1.48164380
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47880211
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46996606
46NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.46739953
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46129240
48POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45805639
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44359961
50* GABP_19822575_ChIP-Seq_HepG2_Human1.44320434
51DCP1A_22483619_ChIP-Seq_HELA_Human1.43519275
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42943474
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40345005
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.39562259
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39495180
56KDM5A_27292631_Chip-Seq_BREAST_Human1.38902481
57TTF2_22483619_ChIP-Seq_HELA_Human1.38526262
58ZNF263_19887448_ChIP-Seq_K562_Human1.37641981
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37604931
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33153816
61ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31302819
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.29743312
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.29142917
64P68_20966046_ChIP-Seq_HELA_Human1.26529446
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26291925
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26032015
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25857029
68KDM2B_26808549_Chip-Seq_DND41_Human1.24760368
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.24752919
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24002383
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23283460
72RACK7_27058665_Chip-Seq_MCF-7_Human1.22943119
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20670496
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20419901
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17891087
76AR_21909140_ChIP-Seq_LNCAP_Human1.16831286
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15108334
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14888525
79TFEB_21752829_ChIP-Seq_HELA_Human1.14047890
80NCOR1_26117541_ChIP-Seq_K562_Human1.13209855
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.13003958
82NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.12702296
83TP63_17297297_ChIP-ChIP_HaCaT_Human1.12441149
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12188268
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11518549
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11386114
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11275811
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10413635
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09804392
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09697369
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09447826
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08675158
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.08518964
94CHD1_26751641_Chip-Seq_LNCaP_Human1.08032370
95VDR_23849224_ChIP-Seq_CD4+_Human1.07482973
96SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07036628
97POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.06986450
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06587023
99TCF7_22412390_ChIP-Seq_EML_Mouse1.06454093
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06357166
101* SA1_27219007_Chip-Seq_ERYTHROID_Human1.06127995
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06089281
103TET1_21451524_ChIP-Seq_MESCs_Mouse1.06062132
104* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05586795
105* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05532071
106* KDM2B_26808549_Chip-Seq_K562_Human1.04326651
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04065913
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.03914800
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03843455
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.03821508
111MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03751495
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02594816
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02377409
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02193898
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02146664
116SMC4_20622854_ChIP-Seq_HELA_Human1.02017084
117RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01766651
118ATF3_27146783_Chip-Seq_COLON_Human1.01115290
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00743762
120P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00466859
121CREB1_26743006_Chip-Seq_LNCaP_Human0.99904061
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99860580
123SOX2_18692474_ChIP-Seq_MESCs_Mouse0.99352078
124* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98846264
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.98357096
126CLOCK_20551151_ChIP-Seq_293T_Human0.97256897
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96603145
128* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94202176
129ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93132723
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91708005

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.03257367
2MP0010030_abnormal_orbit_morphology3.72086684
3MP0009278_abnormal_bone_marrow3.56916892
4MP0010094_abnormal_chromosome_stability3.27871865
5MP0000566_synostosis3.09319236
6MP0004957_abnormal_blastocyst_morpholog3.01890564
7MP0010234_abnormal_vibrissa_follicle3.01810950
8MP0003111_abnormal_nucleus_morphology2.99498517
9MP0010352_gastrointestinal_tract_polyps2.78863926
10MP0004233_abnormal_muscle_weight2.72756329
11MP0004858_abnormal_nervous_system2.67102831
12MP0003693_abnormal_embryo_hatching2.58161089
13MP0003077_abnormal_cell_cycle2.43030185
14MP0005076_abnormal_cell_differentiation2.29428155
15MP0005171_absent_coat_pigmentation2.26560020
16MP0005397_hematopoietic_system_phenotyp2.24015690
17MP0001545_abnormal_hematopoietic_system2.24015690
18MP0004185_abnormal_adipocyte_glucose2.19697930
19MP0005451_abnormal_body_composition2.17660182
20MP0003890_abnormal_embryonic-extraembry2.05818307
21MP0008932_abnormal_embryonic_tissue2.02125682
22MP0008058_abnormal_DNA_repair1.93020447
23MP0003786_premature_aging1.90615404
24MP0001697_abnormal_embryo_size1.90276626
25MP0009672_abnormal_birth_weight1.88798318
26MP0001730_embryonic_growth_arrest1.88432948
27MP0003119_abnormal_digestive_system1.88042787
28MP0002084_abnormal_developmental_patter1.87610714
29MP0000678_abnormal_parathyroid_gland1.86794146
30MP0002086_abnormal_extraembryonic_tissu1.86380741
31MP0004197_abnormal_fetal_growth/weight/1.84388421
32MP0003705_abnormal_hypodermis_morpholog1.82129193
33MP0000350_abnormal_cell_proliferation1.80873826
34MP0000490_abnormal_crypts_of1.77349064
35MP0002085_abnormal_embryonic_tissue1.77286744
36MP0002009_preneoplasia1.76570652
37MP0008995_early_reproductive_senescence1.74240863
38MP0005380_embryogenesis_phenotype1.72178748
39MP0001672_abnormal_embryogenesis/_devel1.72178748
40MP0008877_abnormal_DNA_methylation1.62354375
41MP0001293_anophthalmia1.59128859
42MP0002653_abnormal_ependyma_morphology1.59037961
43MP0003567_abnormal_fetal_cardiomyocyte1.58093035
44MP0003315_abnormal_perineum_morphology1.57213443
45MP0004133_heterotaxia1.56255624
46MP0003283_abnormal_digestive_organ1.53614473
47MP0000467_abnormal_esophagus_morphology1.52525559
48MP0003984_embryonic_growth_retardation1.50020375
49MP0002234_abnormal_pharynx_morphology1.48197085
50MP0002080_prenatal_lethality1.47676247
51MP0002088_abnormal_embryonic_growth/wei1.46092519
52MP0010307_abnormal_tumor_latency1.43626287
53MP0009053_abnormal_anal_canal1.41535771
54MP0008260_abnormal_autophagy1.41504023
55MP0002249_abnormal_larynx_morphology1.39718314
56MP0003453_abnormal_keratinocyte_physiol1.31872372
57MP0001661_extended_life_span1.31505614
58MP0002282_abnormal_trachea_morphology1.28998700
59MP0002396_abnormal_hematopoietic_system1.27220040
60MP0003656_abnormal_erythrocyte_physiolo1.26558641
61MP0002019_abnormal_tumor_incidence1.26249201
62MP0008007_abnormal_cellular_replicative1.26236211
63MP0005174_abnormal_tail_pigmentation1.24113972
64MP0002111_abnormal_tail_morphology1.23351892
65MP0003941_abnormal_skin_development1.18677414
66MP0003718_maternal_effect1.15411744
67MP0002089_abnormal_postnatal_growth/wei1.14451746
68MP0003566_abnormal_cell_adhesion1.11451020
69MP0009333_abnormal_splenocyte_physiolog1.10618659
70MP0000313_abnormal_cell_death1.08815572
71MP0006072_abnormal_retinal_apoptosis1.07601576
72MP0002932_abnormal_joint_morphology1.05546989
73MP0005666_abnormal_adipose_tissue1.04609195
74MP0005623_abnormal_meninges_morphology1.04178338
75MP0009379_abnormal_foot_pigmentation1.02035747
76MP0005023_abnormal_wound_healing1.01995740
77MP0002269_muscular_atrophy1.01595434
78MP0001216_abnormal_epidermal_layer1.01010827
79MP0005621_abnormal_cell_physiology0.96465008
80MP0003935_abnormal_craniofacial_develop0.95727991
81MP0005501_abnormal_skin_physiology0.95475245
82MP0002098_abnormal_vibrissa_morphology0.93153147
83MP0005409_darkened_coat_color0.90546537
84MP0000858_altered_metastatic_potential0.90148445
85MP0003755_abnormal_palate_morphology0.89556750
86MP0000371_diluted_coat_color0.89438379
87MP0000470_abnormal_stomach_morphology0.89038734
88MP0002114_abnormal_axial_skeleton0.86497182
89MP0004264_abnormal_extraembryonic_tissu0.86244532
90MP0001340_abnormal_eyelid_morphology0.85620530
91MP0000432_abnormal_head_morphology0.83964179
92MP0006035_abnormal_mitochondrial_morpho0.83720856
93MP0001873_stomach_inflammation0.83552067
94MP0009931_abnormal_skin_appearance0.82982260
95MP0002697_abnormal_eye_size0.82953120
96MP0002796_impaired_skin_barrier0.82714521
97MP0005384_cellular_phenotype0.82481425
98MP0000477_abnormal_intestine_morphology0.80734733
99MP0003385_abnormal_body_wall0.80628282
100MP0002254_reproductive_system_inflammat0.80235493
101MP0001915_intracranial_hemorrhage0.79986520
102MP0002060_abnormal_skin_morphology0.79142776
103MP0002116_abnormal_craniofacial_bone0.78663881
104MP0000703_abnormal_thymus_morphology0.77478519
105MP0005058_abnormal_lysosome_morphology0.77445665
106MP0001346_abnormal_lacrimal_gland0.76750616
107MP0008770_decreased_survivor_rate0.76086501
108MP0000462_abnormal_digestive_system0.75665833
109MP0002092_abnormal_eye_morphology0.75317096
110MP0001881_abnormal_mammary_gland0.75226911
111MP0000358_abnormal_cell_content/0.74643134
112MP0003123_paternal_imprinting0.74210881
113MP0005508_abnormal_skeleton_morphology0.73292262
114MP0001145_abnormal_male_reproductive0.72646588
115MP0010771_integument_phenotype0.72076279
116MP0003942_abnormal_urinary_system0.71568392
117MP0002925_abnormal_cardiovascular_devel0.71130833
118MP0000377_abnormal_hair_follicle0.70945884
119MP0002075_abnormal_coat/hair_pigmentati0.70868565
120MP0000579_abnormal_nail_morphology0.70769350
121MP0001849_ear_inflammation0.70621597
122MP0000537_abnormal_urethra_morphology0.70217089
123MP0000762_abnormal_tongue_morphology0.68941276
124MP0002877_abnormal_melanocyte_morpholog0.68712463
125MP0003172_abnormal_lysosome_physiology0.68342802
126MP0003115_abnormal_respiratory_system0.68069090
127MP0000003_abnormal_adipose_tissue0.67871393
128MP0010630_abnormal_cardiac_muscle0.67658654
129MP0005375_adipose_tissue_phenotype0.67563085
130MP0004808_abnormal_hematopoietic_stem0.66521235
131MP0000689_abnormal_spleen_morphology0.64773555
132MP0000428_abnormal_craniofacial_morphol0.64613105
133MP0003937_abnormal_limbs/digits/tail_de0.64493433
134MP0009703_decreased_birth_body0.64463739
135MP0001784_abnormal_fluid_regulation0.64210539
136MP0000049_abnormal_middle_ear0.64170777
137MP0000733_abnormal_muscle_development0.63257334
138MP0000627_abnormal_mammary_gland0.61866085

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.89064091
2Facial hemangioma (HP:0000329)4.36537956
3Concave nail (HP:0001598)4.07689263
4Annular pancreas (HP:0001734)3.83281187
5Pustule (HP:0200039)3.83186524
6Poikiloderma (HP:0001029)3.80547108
7Ulnar bowing (HP:0003031)3.78012174
8Selective tooth agenesis (HP:0001592)3.68017631
9Rectovaginal fistula (HP:0000143)3.62042120
10Rectal fistula (HP:0100590)3.62042120
11Short humerus (HP:0005792)3.52120908
12Aplasia/hypoplasia of the humerus (HP:0006507)3.51177378
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.49471614
14Turricephaly (HP:0000262)3.48293175
15Hyperacusis (HP:0010780)3.41486617
16Intestinal fistula (HP:0100819)3.33980307
17Tongue fasciculations (HP:0001308)3.30574305
18Sparse lateral eyebrow (HP:0005338)3.30314166
19Hypochromic microcytic anemia (HP:0004840)3.21943511
20Basal cell carcinoma (HP:0002671)3.21480927
21Vaginal fistula (HP:0004320)3.20986609
22Long palpebral fissure (HP:0000637)3.15136382
23Absent radius (HP:0003974)3.14725877
24Muscle fibrillation (HP:0010546)3.14522705
25Alopecia of scalp (HP:0002293)3.13954594
26Coronal craniosynostosis (HP:0004440)3.05439934
27Squamous cell carcinoma (HP:0002860)3.02646072
28Progressive muscle weakness (HP:0003323)3.00042235
29Patellar aplasia (HP:0006443)2.99867778
30Vertebral hypoplasia (HP:0008417)2.96932247
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.96932247
32Microvesicular hepatic steatosis (HP:0001414)2.96567480
33Orthostatic hypotension (HP:0001278)2.95456508
34Aplasia involving forearm bones (HP:0009822)2.94171703
35Absent forearm bone (HP:0003953)2.94171703
36Absent thumb (HP:0009777)2.90678186
37Abnormal hemoglobin (HP:0011902)2.90401708
38Increased IgM level (HP:0003496)2.84131634
39Congenital hip dislocation (HP:0001374)2.81911377
40Abnormality of the fingertips (HP:0001211)2.79703617
41Aplasia/Hypoplasia of the patella (HP:0006498)2.79596870
42Septate vagina (HP:0001153)2.75586482
43Abnormal gallbladder physiology (HP:0012438)2.75292793
44Cholecystitis (HP:0001082)2.75292793
45Anal stenosis (HP:0002025)2.64490308
46Dysmetric saccades (HP:0000641)2.59941790
47Volvulus (HP:0002580)2.57833842
48Cerebral aneurysm (HP:0004944)2.56917706
49Premature graying of hair (HP:0002216)2.55927479
50Diaphragmatic weakness (HP:0009113)2.54641829
51Abnormality of the astrocytes (HP:0100707)2.52737628
52Astrocytoma (HP:0009592)2.52737628
53Abnormal number of incisors (HP:0011064)2.51076242
54Short chin (HP:0000331)2.48175237
55Abnormality of the aortic arch (HP:0012303)2.46427673
56Reticulocytosis (HP:0001923)2.45751889
57Progressive external ophthalmoplegia (HP:0000590)2.44121081
58Broad alveolar ridges (HP:0000187)2.43733257
59Abnormality of the distal phalanges of the toes (HP:0010182)2.42413309
60Insomnia (HP:0100785)2.42151565
61Short 5th finger (HP:0009237)2.41230284
62Hypochromic anemia (HP:0001931)2.41002679
63Vertebral fusion (HP:0002948)2.40655447
64Abnormality of the labia minora (HP:0012880)2.38717828
65Male infertility (HP:0003251)2.37949826
66Bowing of the arm (HP:0006488)2.37628722
67Bowed forearm bones (HP:0003956)2.37628722
68Anteriorly placed anus (HP:0001545)2.33571214
69Truncus arteriosus (HP:0001660)2.33098797
70Ependymoma (HP:0002888)2.31546363
71Disproportionate tall stature (HP:0001519)2.29982454
72Intestinal atresia (HP:0011100)2.29852012
73Abnormality of reticulocytes (HP:0004312)2.27989058
74Ankyloglossia (HP:0010296)2.27384737
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24549838
76Multiple enchondromatosis (HP:0005701)2.20672677
77Premature skin wrinkling (HP:0100678)2.20637904
78Ragged-red muscle fibers (HP:0003200)2.19517567
79Acute lymphatic leukemia (HP:0006721)2.19469680
80Increased nuchal translucency (HP:0010880)2.18702867
81Urethral obstruction (HP:0000796)2.18054883
82Broad distal phalanx of finger (HP:0009836)2.16326763
83Lip pit (HP:0100267)2.16143583
84Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.15983867
85Neoplasm of the oral cavity (HP:0100649)2.14863077
86Achilles tendon contracture (HP:0001771)2.14199749
87Abnormality of the salivary glands (HP:0010286)2.12170871
88High anterior hairline (HP:0009890)2.09095764
89Self-mutilation (HP:0000742)2.08821156
90Abnormality of male internal genitalia (HP:0000022)2.08622194
91Abnormal number of erythroid precursors (HP:0012131)2.07986825
92Increased number of teeth (HP:0011069)2.06997006
93Abnormality of cells of the erythroid lineage (HP:0012130)2.06499547
94Hypotelorism (HP:0000601)2.05618897
95Choanal stenosis (HP:0000452)2.05452169
96Chromsome breakage (HP:0040012)2.05301076
97Advanced eruption of teeth (HP:0006288)2.04281798
98Ureteral stenosis (HP:0000071)2.03554643
99Dysautonomia (HP:0002459)2.01230056
100Polycythemia (HP:0001901)2.00988710
101Joint stiffness (HP:0001387)2.00303222
102Bifid uvula (HP:0000193)2.00245398
103Albinism (HP:0001022)2.00012205
104Abnormality of the thoracic spine (HP:0100711)1.98366172
105Asymmetry of the thorax (HP:0001555)1.98305404
106Alacrima (HP:0000522)1.97410384
107Hypoplasia of the radius (HP:0002984)1.96425566
108Pili torti (HP:0003777)1.95451989
109Missing ribs (HP:0000921)1.94040567
110Birth length less than 3rd percentile (HP:0003561)1.93861901
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.92698188
112Glioma (HP:0009733)1.92475383
113Spinal muscular atrophy (HP:0007269)1.92068451
114Abnormality of oral frenula (HP:0000190)1.91774649
115Hamartoma (HP:0010566)1.90719069
116Reticulocytopenia (HP:0001896)1.90489748
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90018520
118Distal lower limb amyotrophy (HP:0008944)1.87407526
119Breast hypoplasia (HP:0003187)1.87124661
120Hypotrichosis (HP:0001006)1.87110950
121Broad thumb (HP:0011304)1.87097011
122Abnormality of the calcaneus (HP:0008364)1.86644551
123Pterygium (HP:0001059)1.86340176
124Degeneration of anterior horn cells (HP:0002398)1.85625116
125Abnormality of the anterior horn cell (HP:0006802)1.85625116
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.85491569
127Protrusio acetabuli (HP:0003179)1.85186476
128Capillary hemangiomas (HP:0005306)1.85046563
129Short thumb (HP:0009778)1.84000088
130Abnormality of the Achilles tendon (HP:0005109)1.83789670
131Cholelithiasis (HP:0001081)1.83396869
132Abnormality of the umbilical cord (HP:0010881)1.82904182
133Broad face (HP:0000283)1.82490952
134Generalized amyotrophy (HP:0003700)1.82324355
135Rhabdomyosarcoma (HP:0002859)1.81801438
136Flat acetabular roof (HP:0003180)1.81434742
137Natal tooth (HP:0000695)1.81260058
138Broad hallux (HP:0010055)1.80111172
139Abnormality of the ileum (HP:0001549)1.79747936
140Patellar dislocation (HP:0002999)1.79550686
141Abnormality of glycolysis (HP:0004366)1.79234464
142Abdominal situs inversus (HP:0003363)1.79117192
143Abnormality of abdominal situs (HP:0011620)1.79117192
144Pancreatic islet-cell hyperplasia (HP:0004510)1.78905580
145Hemivertebrae (HP:0002937)1.78883818
146Preauricular skin tag (HP:0000384)1.78607597
147Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78596637
148Short 4th metacarpal (HP:0010044)1.78596637
149Muscle fiber atrophy (HP:0100295)1.77733428
150Bowel incontinence (HP:0002607)1.75546415
151Split hand (HP:0001171)1.74606764
152Ureteral obstruction (HP:0006000)1.74560807
153Hypertensive crisis (HP:0100735)1.73474731
154Proximal placement of thumb (HP:0009623)1.73461147
155Rough bone trabeculation (HP:0100670)1.73137664
156Abnormality of nail color (HP:0100643)1.72520021
157Trismus (HP:0000211)1.72343020
158Deviation of the thumb (HP:0009603)1.71651126
159Thoracic kyphosis (HP:0002942)1.71411921
160Abnormality of the gallbladder (HP:0005264)1.71334000
161Seborrheic dermatitis (HP:0001051)1.71307005
162Abnormal large intestine physiology (HP:0012700)1.68860847
163Hyperthyroidism (HP:0000836)1.67150871
164Testicular atrophy (HP:0000029)1.67140365
165Abnormality of cochlea (HP:0000375)1.67128313
166Leiomyosarcoma (HP:0100243)1.65736687
167Uterine leiomyosarcoma (HP:0002891)1.65736687
168Increased connective tissue (HP:0009025)1.63994635
169Overriding aorta (HP:0002623)1.63856278
170Pointed chin (HP:0000307)1.63746148
171Facial cleft (HP:0002006)1.62405469
172Spastic diplegia (HP:0001264)1.62357217
173Shallow orbits (HP:0000586)1.60873345
174Premature ovarian failure (HP:0008209)1.60012511
175Abnormality of the phalanges of the hallux (HP:0010057)1.57311047
176Abnormality of the tricuspid valve (HP:0001702)1.54862056
177Deep palmar crease (HP:0006191)1.54798861
178Renal cell carcinoma (HP:0005584)1.54441306
179Pallor (HP:0000980)1.54278261
180Atresia of the external auditory canal (HP:0000413)1.52766972
181Abnormally folded helix (HP:0008544)1.52584069
182Neonatal death (HP:0003811)1.51993515
183Pseudobulbar signs (HP:0002200)1.51073897
184Duplication of thumb phalanx (HP:0009942)1.50426426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.17093608
2SMG14.73223780
3DDR24.19627712
4MAP3K113.34178531
5MAP3K63.33506148
6MAPK152.88171580
7IRAK32.46500454
8TYRO32.45087610
9PRPF4B2.41552576
10MATK2.22127377
11BMX2.20407785
12CDK72.18118178
13PIM22.16585158
14MAP3K102.06330955
15FGR2.03475520
16PDGFRA1.99609288
17VRK21.98910015
18SIK11.94429396
19CDC71.91528225
20DAPK11.84389812
21LATS21.79739567
22CDK121.75616531
23MST1R1.71967333
24UHMK11.66598681
25TRIB31.65446735
26PRKD21.65377122
27DYRK1B1.62388526
28CDK61.62153434
29PINK11.60494487
30CAMK1D1.59728150
31EEF2K1.58724580
32BUB11.56210678
33CSK1.50538260
34RPS6KB21.47420978
35STK241.47100466
36NEK21.46600282
37WEE11.45359399
38DYRK31.41613369
39PRKD31.41357899
40PIM11.40981047
41CHEK21.38248022
42PLK11.31349413
43SRPK11.30460267
44TAF11.30369022
45TRPM71.30157994
46YES11.23624862
47PBK1.19055526
48CAMK1G1.18547445
49TSSK61.14207298
50ATR1.12337887
51MTOR1.09302475
52RPS6KL11.08553633
53RPS6KC11.08553633
54EPHA21.08236862
55NEK11.07092303
56STK101.03507109
57MAP3K31.03123168
58ERN11.01491387
59CDK41.00100881
60ARAF0.99978914
61BRAF0.99962018
62MAPK110.95896846
63AURKA0.95885251
64TESK20.93352850
65RPS6KA60.93066228
66ILK0.90568143
67CDC42BPA0.87692263
68TAOK20.87042254
69FGFR40.85876991
70TTK0.85492086
71PKN20.84221674
72PAK40.84073336
73AURKB0.83640770
74GSK3A0.81969232
75CCNB10.80855464
76CHEK10.79240720
77MAP3K80.78739966
78CDK20.76478691
79IRAK20.73945052
80MAP3K20.73479844
81RPS6KA10.72481202
82CDK80.71680680
83CDK90.69670408
84PASK0.69646660
85ALK0.69188236
86NME20.67603149
87PAK20.67344268
88MAP3K90.67088657
89MAPKAPK50.66980517
90SCYL20.66898689
91LMTK20.64514716
92NME10.64197506
93TLK10.63848680
94STK30.63319178
95MET0.61630185
96MAP2K30.61345073
97ATM0.59031619
98ACVR1B0.58759555
99KSR20.58532775
100PTK60.58289457
101TAOK10.56605066
102HIPK20.54725455
103RPS6KA20.54200053
104RIPK10.53677965
105EIF2AK10.52343559
106MAPKAPK30.52170935
107PAK10.51611126
108MAP4K10.50806929
109LRRK20.50589562
110CSNK2A10.50238238
111FGFR10.49533232
112PHKG20.48252325
113PHKG10.48252325
114AKT30.48124198
115RPS6KB10.47643440
116LATS10.47351594
117PTK20.47200829
118BRSK20.46446279
119RPS6KA40.46347379
120CDK10.45753485
121CSNK2A20.45305859
122BRD40.45038766
123NTRK10.43040821
124BRSK10.42554238
125PRKCI0.42407854
126MAP2K20.42255998
127STK40.41781712
128KDR0.40548251
129MAPKAPK20.40162726
130MAPK10.39811482
131TTN0.39283021
132AKT20.38585884
133RAF10.38235666
134FLT30.38197918
135PRKAA10.37596180
136EGFR0.37342394
137MAP3K10.36768702
138MAPK140.35705958
139PDGFRB0.34584987
140CLK10.33784491
141MELK0.33583508
142MAPK30.32379877

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.74128239
2DNA replication_Homo sapiens_hsa030304.64071316
3Base excision repair_Homo sapiens_hsa034104.20156072
4Fatty acid biosynthesis_Homo sapiens_hsa000613.01021502
5Spliceosome_Homo sapiens_hsa030402.86334616
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82049903
7RNA transport_Homo sapiens_hsa030132.76825023
8Nucleotide excision repair_Homo sapiens_hsa034202.58147748
9Cell cycle_Homo sapiens_hsa041102.35785946
10Homologous recombination_Homo sapiens_hsa034402.23380885
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20384671
12mRNA surveillance pathway_Homo sapiens_hsa030152.19557669
13Ribosome_Homo sapiens_hsa030102.13851187
14One carbon pool by folate_Homo sapiens_hsa006701.99377422
15Vitamin B6 metabolism_Homo sapiens_hsa007501.95795700
16p53 signaling pathway_Homo sapiens_hsa041151.95500756
17Fanconi anemia pathway_Homo sapiens_hsa034601.79571060
18Hippo signaling pathway_Homo sapiens_hsa043901.72799953
19Carbon metabolism_Homo sapiens_hsa012001.68882140
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65521796
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.65115067
22Bladder cancer_Homo sapiens_hsa052191.58453876
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57219072
24mTOR signaling pathway_Homo sapiens_hsa041501.55277300
25Sulfur relay system_Homo sapiens_hsa041221.55198803
26Arginine biosynthesis_Homo sapiens_hsa002201.54396450
27Notch signaling pathway_Homo sapiens_hsa043301.53673408
28Hedgehog signaling pathway_Homo sapiens_hsa043401.49231188
29Adherens junction_Homo sapiens_hsa045201.46872182
30Biosynthesis of amino acids_Homo sapiens_hsa012301.41643586
31Basal cell carcinoma_Homo sapiens_hsa052171.27023326
32Pyruvate metabolism_Homo sapiens_hsa006201.25136096
33TGF-beta signaling pathway_Homo sapiens_hsa043501.21245967
34Proteasome_Homo sapiens_hsa030501.17809153
35MicroRNAs in cancer_Homo sapiens_hsa052061.13255754
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12334125
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10474916
38RNA polymerase_Homo sapiens_hsa030201.10168678
39Chronic myeloid leukemia_Homo sapiens_hsa052201.09506560
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08646650
41Shigellosis_Homo sapiens_hsa051311.08255848
42Oocyte meiosis_Homo sapiens_hsa041141.06735235
43Colorectal cancer_Homo sapiens_hsa052101.04547526
44Pyrimidine metabolism_Homo sapiens_hsa002401.03069291
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02412101
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02065456
47Viral carcinogenesis_Homo sapiens_hsa052031.01610495
48Small cell lung cancer_Homo sapiens_hsa052221.00056883
49RNA degradation_Homo sapiens_hsa030180.99377489
50Arginine and proline metabolism_Homo sapiens_hsa003300.96368508
51Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95277658
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95162175
53Lysine degradation_Homo sapiens_hsa003100.93345850
54Thyroid cancer_Homo sapiens_hsa052160.93147792
55Wnt signaling pathway_Homo sapiens_hsa043100.93002364
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90722965
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89281014
58Folate biosynthesis_Homo sapiens_hsa007900.89269715
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87467560
60Non-homologous end-joining_Homo sapiens_hsa034500.84164916
61Circadian rhythm_Homo sapiens_hsa047100.82942886
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82368950
63HTLV-I infection_Homo sapiens_hsa051660.81960295
64Viral myocarditis_Homo sapiens_hsa054160.77551157
65Glioma_Homo sapiens_hsa052140.76504563
66Epstein-Barr virus infection_Homo sapiens_hsa051690.76199245
67Acute myeloid leukemia_Homo sapiens_hsa052210.74244977
68VEGF signaling pathway_Homo sapiens_hsa043700.72630910
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72589459
70Primary immunodeficiency_Homo sapiens_hsa053400.70290473
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.68067532
72Prion diseases_Homo sapiens_hsa050200.65097160
73Tight junction_Homo sapiens_hsa045300.63905080
74Proteoglycans in cancer_Homo sapiens_hsa052050.63849390
75Basal transcription factors_Homo sapiens_hsa030220.62616213
76Renal cell carcinoma_Homo sapiens_hsa052110.61668959
77Purine metabolism_Homo sapiens_hsa002300.60151668
78Herpes simplex infection_Homo sapiens_hsa051680.59835603
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59465093
80Legionellosis_Homo sapiens_hsa051340.58513041
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57817119
82Other glycan degradation_Homo sapiens_hsa005110.56393891
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.55946705
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55840381
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54541878
86Endometrial cancer_Homo sapiens_hsa052130.53706522
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.53641757
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53316834
89Fructose and mannose metabolism_Homo sapiens_hsa000510.52725910
90AMPK signaling pathway_Homo sapiens_hsa041520.51944745
91Phenylalanine metabolism_Homo sapiens_hsa003600.51559687
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51090849
93Selenocompound metabolism_Homo sapiens_hsa004500.50651340
94Hepatitis B_Homo sapiens_hsa051610.49234700
95Alcoholism_Homo sapiens_hsa050340.46632381
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.46136729
97Pathways in cancer_Homo sapiens_hsa052000.45054925
98Systemic lupus erythematosus_Homo sapiens_hsa053220.44579378
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44369264
100Prostate cancer_Homo sapiens_hsa052150.43504577
101Glutathione metabolism_Homo sapiens_hsa004800.43337686
102Pancreatic cancer_Homo sapiens_hsa052120.42815926
103Non-small cell lung cancer_Homo sapiens_hsa052230.42658953
104Galactose metabolism_Homo sapiens_hsa000520.42539057
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.42494363
106Focal adhesion_Homo sapiens_hsa045100.41576845
107Apoptosis_Homo sapiens_hsa042100.40428562
108HIF-1 signaling pathway_Homo sapiens_hsa040660.38447718
109Insulin signaling pathway_Homo sapiens_hsa049100.38222706
110PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37487023
111N-Glycan biosynthesis_Homo sapiens_hsa005100.37363916
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35509795
113Fatty acid metabolism_Homo sapiens_hsa012120.34650679
114Fatty acid elongation_Homo sapiens_hsa000620.34489725
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32787364
116Gap junction_Homo sapiens_hsa045400.30763417
117Melanoma_Homo sapiens_hsa052180.30618876
118Glucagon signaling pathway_Homo sapiens_hsa049220.30338674
119ErbB signaling pathway_Homo sapiens_hsa040120.29613770
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27472982
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27225658
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25313011
123Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24475811
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.24191576
125Pentose phosphate pathway_Homo sapiens_hsa000300.23577313
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.22666676

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