TTLL13P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-8 production (GO:0032717)7.08651984
2hematopoietic stem cell proliferation (GO:0071425)6.46990615
3serotonin receptor signaling pathway (GO:0007210)6.35506612
4lymphangiogenesis (GO:0001946)5.69612301
5positive regulation of osteoblast proliferation (GO:0033690)5.69299726
6establishment of protein localization to Golgi (GO:0072600)5.61876044
7sperm motility (GO:0030317)5.38131754
8positive regulation of hair follicle development (GO:0051798)5.22068765
9positive regulation of hair cycle (GO:0042635)5.22068765
10negative regulation of circadian rhythm (GO:0042754)5.19596361
11detection of light stimulus involved in visual perception (GO:0050908)5.09570604
12detection of light stimulus involved in sensory perception (GO:0050962)5.09570604
13negative regulation of calcium ion transport into cytosol (GO:0010523)5.03181200
14protein K63-linked deubiquitination (GO:0070536)5.01536326
15cilium or flagellum-dependent cell motility (GO:0001539)5.00148746
16interferon-gamma production (GO:0032609)4.99890013
17protein K48-linked deubiquitination (GO:0071108)4.81513142
18organic cation transport (GO:0015695)4.70892616
19regulation of appetite (GO:0032098)4.67040809
20protein targeting to Golgi (GO:0000042)4.65768336
21mucosal immune response (GO:0002385)4.61451747
22cysteine metabolic process (GO:0006534)4.57584650
23angiogenesis involved in wound healing (GO:0060055)4.52677523
24regulation of Cdc42 GTPase activity (GO:0043088)4.51883707
25acrosome reaction (GO:0007340)4.51584890
26organ or tissue specific immune response (GO:0002251)4.37589976
27cellular ketone body metabolic process (GO:0046950)4.26172697
28carnitine transmembrane transport (GO:1902603)4.25041616
29sulfate transmembrane transport (GO:1902358)4.19913820
30retrograde transport, vesicle recycling within Golgi (GO:0000301)4.14277358
31thyroid hormone metabolic process (GO:0042403)3.95067411
32sperm capacitation (GO:0048240)3.93986327
33indole-containing compound catabolic process (GO:0042436)3.89625887
34indolalkylamine catabolic process (GO:0046218)3.89625887
35tryptophan catabolic process (GO:0006569)3.89625887
36amino-acid betaine transport (GO:0015838)3.79899373
37carnitine transport (GO:0015879)3.79899373
38sulfation (GO:0051923)3.78159342
39disruption of cells of other organism (GO:0044364)3.77053232
40killing of cells of other organism (GO:0031640)3.77053232
41carnitine metabolic process (GO:0009437)3.76355532
42cholesterol catabolic process (GO:0006707)3.72558884
43sterol catabolic process (GO:0016127)3.72558884
44spermatid development (GO:0007286)3.71314382
45sex differentiation (GO:0007548)3.70926739
46regulation of apoptotic process involved in morphogenesis (GO:1902337)3.70353825
47ketone body metabolic process (GO:1902224)3.68354294
48protein localization to Golgi apparatus (GO:0034067)3.67537672
49glycoprotein catabolic process (GO:0006516)3.61617573
50activated T cell proliferation (GO:0050798)3.60066714
51homocysteine metabolic process (GO:0050667)3.59783806
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59431227
53nuclear pore organization (GO:0006999)3.58568247
54NAD biosynthetic process (GO:0009435)3.53846665
55multicellular organism reproduction (GO:0032504)3.53170742
56glycerophospholipid catabolic process (GO:0046475)3.51959495
57omega-hydroxylase P450 pathway (GO:0097267)3.51838682
58DNA integration (GO:0015074)3.51030855
59sulfate transport (GO:0008272)3.47663729
60signal peptide processing (GO:0006465)3.38421779
61protein-cofactor linkage (GO:0018065)3.36447633
62regulation of B cell receptor signaling pathway (GO:0050855)3.33048833
63zinc ion homeostasis (GO:0055069)3.29910725
64negative regulation of mast cell activation (GO:0033004)3.29814151
65fusion of sperm to egg plasma membrane (GO:0007342)3.24494525
66filopodium assembly (GO:0046847)3.23799672
67positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.21518100
68regulation of female gonad development (GO:2000194)3.14560145
69flavonoid metabolic process (GO:0009812)3.14258601
70granulocyte differentiation (GO:0030851)3.08476742
71phospholipid translocation (GO:0045332)3.06889959
72lipid translocation (GO:0034204)3.06889959
73peptidyl-threonine dephosphorylation (GO:0035970)3.04509798
74negative regulation of metanephros development (GO:0072217)3.03014991
75regulation of sarcomere organization (GO:0060297)3.02161134
76tryptophan metabolic process (GO:0006568)2.99738155
77negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.96898422
78RNA localization (GO:0006403)2.95310907
79protein K6-linked ubiquitination (GO:0085020)2.94184405
80cellular zinc ion homeostasis (GO:0006882)2.93971595
81indolalkylamine metabolic process (GO:0006586)2.91208796
82defense response to fungus (GO:0050832)2.89654349
83amine catabolic process (GO:0009310)2.88295057
84cellular biogenic amine catabolic process (GO:0042402)2.88295057
85positive regulation of cAMP-mediated signaling (GO:0043950)2.88266071
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.87475208
87rRNA methylation (GO:0031167)2.82832762
88regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.79411291
89negative regulation of neurotransmitter secretion (GO:0046929)2.78645286
90amino-acid betaine metabolic process (GO:0006577)2.78334277
91quaternary ammonium group transport (GO:0015697)2.76926337
92androgen biosynthetic process (GO:0006702)2.75358857
93photoreceptor cell maintenance (GO:0045494)2.74994077
94reproduction (GO:0000003)2.74265134
95retinal cone cell development (GO:0046549)2.72647851
96regulation of hair follicle development (GO:0051797)2.71903290
97regulation of cilium movement (GO:0003352)2.71419286
98single strand break repair (GO:0000012)2.71117939
99regulation of establishment of cell polarity (GO:2000114)2.68529996
100protein K11-linked deubiquitination (GO:0035871)11.7324858

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse6.47943424
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.47651221
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.13030681
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.96038380
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.94029512
6GBX2_23144817_ChIP-Seq_PC3_Human2.79008476
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.75573437
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.74650020
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.72046826
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.36259494
11DROSHA_22980978_ChIP-Seq_HELA_Human2.24561839
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse10.3412680
13ER_23166858_ChIP-Seq_MCF-7_Human1.95963948
14NOTCH1_21737748_ChIP-Seq_TLL_Human1.73090358
15TAF15_26573619_Chip-Seq_HEK293_Human1.69755145
16LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53464458
17ERA_21632823_ChIP-Seq_H3396_Human1.47955313
18ZNF274_21170338_ChIP-Seq_K562_Hela1.44627916
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.42984655
20JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39087832
21IRF8_21731497_ChIP-ChIP_J774_Mouse1.37710017
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36958663
23AR_25329375_ChIP-Seq_VCAP_Human1.33827734
24TP53_22573176_ChIP-Seq_HFKS_Human1.33117362
25GATA3_21878914_ChIP-Seq_MCF-7_Human1.32636306
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.30787015
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.29378729
28PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29180587
29FOXA1_21572438_ChIP-Seq_LNCaP_Human1.27581911
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27512888
31VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.26733892
32DCP1A_22483619_ChIP-Seq_HELA_Human1.26361525
33AR_21572438_ChIP-Seq_LNCaP_Human1.22430404
34IGF1R_20145208_ChIP-Seq_DFB_Human1.20285100
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19638815
36ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19605839
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18416936
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17396120
39CTCF_20526341_ChIP-Seq_ESCs_Human1.15996874
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15647966
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13259051
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12324837
43CBP_20019798_ChIP-Seq_JUKART_Human1.12324837
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11578502
45ERG_20517297_ChIP-Seq_VCAP_Human1.11050285
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10215269
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.10215269
48EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10165904
49STAT1_20625510_ChIP-Seq_HELA_Human1.09189691
50CJUN_26792858_Chip-Seq_BT549_Human1.07110836
51PHF8_20622853_ChIP-Seq_HELA_Human1.07106938
52STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05721000
53HOXB7_26014856_ChIP-Seq_BT474_Human1.03556623
54SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03029620
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02838161
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.02806819
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.02329990
58ELF5_23300383_ChIP-Seq_T47D_Human1.01555420
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99615272
60ELK1_22589737_ChIP-Seq_MCF10A_Human0.99426860
61JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98901339
62HNFA_21074721_ChIP-Seq_CACO-2_Human0.98713231
63MYC_19829295_ChIP-Seq_ESCs_Human0.98606569
64GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98349306
65WDR5_24793694_ChIP-Seq_LNCAP_Human0.97410344
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96934692
67STAT3_23295773_ChIP-Seq_U87_Human0.96530941
68RBPJ_21746931_ChIP-Seq_IB4_Human0.95700175
69BCL6_27268052_Chip-Seq_Bcells_Human0.95250465
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93043791
71CEBPB_22108803_ChIP-Seq_LS180_Human0.91985945
72AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91795487
73CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91783381
74E2F1_20622854_ChIP-Seq_HELA_Human0.90860667
75CDX2_22108803_ChIP-Seq_LS180_Human0.90182016
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90129240
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89952081
78TP53_18474530_ChIP-ChIP_U2OS_Human0.89519698
79KDM5A_27292631_Chip-Seq_BREAST_Human0.88765258
80GABP_17652178_ChIP-ChIP_JURKAT_Human0.87584439
81E2F1_21310950_ChIP-Seq_MCF-7_Human0.87388365
82IRF8_22096565_ChIP-ChIP_GC-B_Human0.86664263
83ETV1_20927104_ChIP-Seq_GIST48_Human0.85681707
84P53_21459846_ChIP-Seq_SAOS-2_Human0.85362036
85ETS1_21867929_ChIP-Seq_TH2_Mouse0.85148740
86PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84335443
87NCOR_22424771_ChIP-Seq_293T_Human0.84198979
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84024540
89YY1_22570637_ChIP-Seq_MALME-3M_Human0.83515163
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82551092
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.81691507
92VDR_23849224_ChIP-Seq_CD4+_Human0.81221581
93BCOR_27268052_Chip-Seq_Bcells_Human0.80803497
94TAF2_19829295_ChIP-Seq_ESCs_Human0.79405103
95NANOG_20526341_ChIP-Seq_ESCs_Human0.78543732
96P300_27268052_Chip-Seq_Bcells_Human0.77424233
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.77324017
98FOXP3_21729870_ChIP-Seq_TREG_Human0.76863932
99ARNT_22903824_ChIP-Seq_MCF-7_Human0.76816587
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.76315826

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.96248134
2MP0003183_abnormal_peptide_metabolism4.92812195
3MP0008875_abnormal_xenobiotic_pharmacok4.30813333
4MP0005410_abnormal_fertilization4.14639407
5MP0002138_abnormal_hepatobiliary_system3.94788956
6MP0005310_abnormal_salivary_gland3.64479461
7MP0002254_reproductive_system_inflammat3.57395940
8MP0005360_urolithiasis3.20259670
9MP0003878_abnormal_ear_physiology2.63970740
10MP0005377_hearing/vestibular/ear_phenot2.63970740
11MP0001984_abnormal_olfaction2.45448335
12MP0002653_abnormal_ependyma_morphology2.08989806
13MP0002006_tumorigenesis2.05615518
14MP0005551_abnormal_eye_electrophysiolog1.97496786
15MP0005647_abnormal_sex_gland1.94235830
16MP0008004_abnormal_stomach_pH1.93717422
17MP0000013_abnormal_adipose_tissue1.90438644
18MP0002139_abnormal_hepatobiliary_system1.86380952
19MP0001879_abnormal_lymphatic_vessel1.79959044
20MP0002009_preneoplasia1.78874412
21MP0003315_abnormal_perineum_morphology1.77516011
22MP0001873_stomach_inflammation1.74736078
23MP0001502_abnormal_circadian_rhythm1.69284625
24MP0004043_abnormal_pH_regulation1.66884164
25MP0003698_abnormal_male_reproductive1.66054526
26MP0001919_abnormal_reproductive_system1.63915126
27MP0001986_abnormal_taste_sensitivity1.61041000
28MP0000613_abnormal_salivary_gland1.56194899
29MP0001348_abnormal_lacrimal_gland1.53940863
30MP0004264_abnormal_extraembryonic_tissu1.50521145
31MP0001764_abnormal_homeostasis1.46690808
32MP0001929_abnormal_gametogenesis1.45296369
33MP0006082_CNS_inflammation1.43209649
34MP0003718_maternal_effect1.38071432
35MP0004233_abnormal_muscle_weight1.36646004
36MP0005365_abnormal_bile_salt1.34713803
37MP0002132_abnormal_respiratory_system1.27398558
38MP0000538_abnormal_urinary_bladder1.25332632
39MP0008961_abnormal_basal_metabolism1.23238275
40MP0002736_abnormal_nociception_after1.22576597
41MP0005332_abnormal_amino_acid1.22388843
42MP0005083_abnormal_biliary_tract1.22186685
43MP0001968_abnormal_touch/_nociception1.20684081
44MP0003045_fibrosis1.20310421
45MP0002970_abnormal_white_adipose1.16993942
46MP0006276_abnormal_autonomic_nervous1.16523106
47MP0002210_abnormal_sex_determination1.15415288
48MP0004145_abnormal_muscle_electrophysio1.15272626
49MP0008877_abnormal_DNA_methylation1.15240601
50MP0003806_abnormal_nucleotide_metabolis1.15076233
51MP0001485_abnormal_pinna_reflex1.14214075
52MP0009745_abnormal_behavioral_response1.05044812
53MP0000003_abnormal_adipose_tissue1.03623874
54MP0001501_abnormal_sleep_pattern1.02022562
55MP0002837_dystrophic_cardiac_calcinosis1.02010576
56MP0000371_diluted_coat_color1.00444326
57MP0005389_reproductive_system_phenotype0.99904511
58MP0000470_abnormal_stomach_morphology0.97388317
59MP0008873_increased_physiological_sensi0.93768135
60MP0005623_abnormal_meninges_morphology0.92782963
61MP0002928_abnormal_bile_duct0.90654548
62MP0005253_abnormal_eye_physiology0.88970649
63MP0002161_abnormal_fertility/fecundity0.88885687
64MP0004142_abnormal_muscle_tone0.88345191
65MP0001145_abnormal_male_reproductive0.87624499
66MP0003252_abnormal_bile_duct0.87290505
67MP0003936_abnormal_reproductive_system0.87171074
68MP0009278_abnormal_bone_marrow0.83811890
69MP0002064_seizures0.82930439
70MP0002971_abnormal_brown_adipose0.82209921
71MP0009046_muscle_twitch0.80446837
72MP0005423_abnormal_somatic_nervous0.79227596
73MP0000653_abnormal_sex_gland0.78610097
74MP0002166_altered_tumor_susceptibility0.76117856
75MP0002735_abnormal_chemical_nociception0.74333358
76MP0001486_abnormal_startle_reflex0.71598107
77MP0000627_abnormal_mammary_gland0.71536684
78MP0001664_abnormal_digestion0.71065957
79MP0001270_distended_abdomen0.70542641
80MP0000230_abnormal_systemic_arterial0.70229333
81MP0009643_abnormal_urine_homeostasis0.68896104
82MP0003693_abnormal_embryo_hatching0.67676844
83MP0005452_abnormal_adipose_tissue0.66566592
84MP0003638_abnormal_response/metabolism_0.65768520
85MP0001324_abnormal_eye_pigmentation0.64829598
86MP0002090_abnormal_vision0.63869547
87MP0002572_abnormal_emotion/affect_behav0.63584643
88MP0002277_abnormal_respiratory_mucosa0.63337577
89MP0004147_increased_porphyrin_level0.62628234
90MP0010155_abnormal_intestine_physiology0.60173112
91MP0002118_abnormal_lipid_homeostasis0.59626464
92MP0002135_abnormal_kidney_morphology0.59610648
93MP0002136_abnormal_kidney_physiology0.59217401
94MP0010368_abnormal_lymphatic_system0.58758847
95MP0010329_abnormal_lipoprotein_level0.58355859
96MP0000609_abnormal_liver_physiology0.57966029
97MP0003646_muscle_fatigue0.57569467
98MP0000569_abnormal_digit_pigmentation0.57462065
99MP0002160_abnormal_reproductive_system0.54859306
100MP0009764_decreased_sensitivity_to0.54716515

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)4.73112582
2Congenital sensorineural hearing impairment (HP:0008527)4.48071273
3Attenuation of retinal blood vessels (HP:0007843)4.38825572
4Bony spicule pigmentary retinopathy (HP:0007737)3.83255655
5Bilateral sensorineural hearing impairment (HP:0008619)3.78671797
6Poikiloderma (HP:0001029)3.77124146
7Abnormal spermatogenesis (HP:0008669)3.65974141
8Pancreatic fibrosis (HP:0100732)3.55037996
9Retrobulbar optic neuritis (HP:0100654)3.53565953
10Optic neuritis (HP:0100653)3.53565953
11True hermaphroditism (HP:0010459)3.40901729
12Pancreatic cysts (HP:0001737)3.39892287
13Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.38957423
14Lower limb hyperreflexia (HP:0002395)3.33214614
15Polydipsia (HP:0001959)3.32806074
16Abnormal drinking behavior (HP:0030082)3.32806074
17Orchitis (HP:0100796)3.29582839
18Congenital stationary night blindness (HP:0007642)3.25947580
19Infertility (HP:0000789)3.04609868
20Severe visual impairment (HP:0001141)3.04563407
21Prostate neoplasm (HP:0100787)3.03936570
22Clumsiness (HP:0002312)3.03508458
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.02718056
24Gonadotropin excess (HP:0000837)2.91441074
25Bile duct proliferation (HP:0001408)2.90807619
26Abnormal biliary tract physiology (HP:0012439)2.90807619
27Abnormality of dental color (HP:0011073)2.89754553
28Abnormality of the renal cortex (HP:0011035)2.86876408
29Chronic hepatic failure (HP:0100626)2.86078790
30Keratoconjunctivitis (HP:0001096)2.84977084
31Abolished electroretinogram (ERG) (HP:0000550)2.84849696
32Abnormality of the pericardium (HP:0001697)2.80596626
33Tubular atrophy (HP:0000092)2.76167421
34Polyuria (HP:0000103)2.71533441
35Abnormality of DNA repair (HP:0003254)2.71109793
36Male pseudohermaphroditism (HP:0000037)2.68987809
37Decreased circulating renin level (HP:0003351)2.60515819
38Nephronophthisis (HP:0000090)2.60128526
39Abnormality of the renal medulla (HP:0100957)2.59643827
40Unilateral renal agenesis (HP:0000122)2.58802302
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.51733524
42Absent/shortened dynein arms (HP:0200106)2.51733524
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48876695
44Male infertility (HP:0003251)2.47010542
45Abnormal urine output (HP:0012590)2.39976588
46Absent speech (HP:0001344)2.36613343
47Testicular atrophy (HP:0000029)2.36288425
48Hyperkalemia (HP:0002153)2.35758133
49Hypoplasia of the uterus (HP:0000013)2.34466534
50Increased cerebral lipofuscin (HP:0011813)2.33130428
51Myositis (HP:0100614)2.32791510
52Generalized hypopigmentation of hair (HP:0011358)2.30837996
53Recurrent corneal erosions (HP:0000495)2.30396145
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.28573458
55J-shaped sella turcica (HP:0002680)2.27812119
56Horizontal nystagmus (HP:0000666)2.27736642
57Cystic liver disease (HP:0006706)2.27484496
58Abnormality of chloride homeostasis (HP:0011422)2.26327228
59Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20507685
60Hyperglycinuria (HP:0003108)2.12559899
61Tinnitus (HP:0000360)2.12414048
62Abnormal ciliary motility (HP:0012262)2.08636651
63Abnormality of midbrain morphology (HP:0002418)2.07773960
64Molar tooth sign on MRI (HP:0002419)2.07773960
65Abnormal respiratory epithelium morphology (HP:0012253)2.07191912
66Abnormal respiratory motile cilium morphology (HP:0005938)2.07191912
67Keratoconjunctivitis sicca (HP:0001097)2.06893193
68Amelogenesis imperfecta (HP:0000705)2.06546598
69Abnormal pancreas size (HP:0012094)2.05207719
70Anorexia (HP:0002039)2.04234445
71Abnormal respiratory motile cilium physiology (HP:0012261)2.02966615
72Chorioretinal coloboma (HP:0000567)2.02116895
73Deformed sella turcica (HP:0002681)2.00670978
74Bicuspid aortic valve (HP:0001647)2.00045393
75Mesangial abnormality (HP:0001966)1.99251264
76Potter facies (HP:0002009)1.95924439
77Facial shape deformation (HP:0011334)1.95924439
78Stage 5 chronic kidney disease (HP:0003774)1.95363408
79Hyperaldosteronism (HP:0000859)1.94388559
80Abnormality of renal excretion (HP:0011036)1.94197464
81Alveolar cell carcinoma (HP:0006519)1.93832522
82Keratitis (HP:0000491)1.92797894
83Photophobia (HP:0000613)1.90611158
84Abnormality of glutamine family amino acid metabolism (HP:0010902)1.87983057
85Occipital encephalocele (HP:0002085)1.87020916
86Abnormal rod and cone electroretinograms (HP:0008323)1.82958291
87Chronic bronchitis (HP:0004469)1.82518528
88Genetic anticipation (HP:0003743)1.82500156
89Flat capital femoral epiphysis (HP:0003370)1.81056216
90Bulbous nose (HP:0000414)1.78167907
91Renal cortical cysts (HP:0000803)1.77311677
92Abnormality of the sella turcica (HP:0002679)1.75484719
93Generalized aminoaciduria (HP:0002909)1.74719496
94Ileus (HP:0002595)1.73845253
95Esotropia (HP:0000565)1.73506622
96Prominent supraorbital ridges (HP:0000336)1.72155884
97Abnormality of the prostate (HP:0008775)1.71297391
98Hemoptysis (HP:0002105)1.70780699
99Bicornuate uterus (HP:0000813)1.68448094
100Abnormality of male internal genitalia (HP:0000022)1.66651099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK7.42134477
2TLK17.28289721
3FRK5.56348961
4WNK33.31916257
5STK38L2.40370206
6EPHA22.37021978
7CDK122.28197920
8TXK2.25672931
9TNK21.95481044
10STK161.91516442
11BLK1.89602716
12MST41.76440221
13EEF2K1.74881939
14MAPKAPK31.73295806
15FER1.67235936
16PINK11.53191916
17BCKDK1.50562683
18CASK1.44496967
19RPS6KA51.41854699
20VRK11.40478183
21STK241.34303556
22IKBKB1.33766375
23MAPK111.27176366
24PDK21.22940207
25WNK41.19859295
26GRK11.10665504
27BMPR21.09969266
28ADRBK21.08283516
29STK391.02541058
30MAPK131.01740888
31BRSK20.99900402
32NTRK30.98033389
33PDK10.97712029
34PDPK10.95932759
35MAPK150.95883825
36PLK40.94249833
37CHEK20.85500784
38WEE10.80415781
39PRKCQ0.78613181
40STK380.74604737
41MAPKAPK50.74023476
42NEK60.71783183
43TRPM70.70453258
44BRD40.69265910
45PRKCZ0.68696752
46OXSR10.67886113
47FLT30.67210206
48PKN10.65976947
49ICK0.65612610
50PIM20.64633059
51ABL20.64308390
52MET0.63607519
53IRAK10.58523020
54TAOK30.58416439
55MAP3K80.51343128
56MST1R0.50090568
57AURKA0.49711852
58MAP3K110.49421142
59AKT30.48088438
60PIM10.46957308
61TEC0.46183946
62SIK30.45425494
63MTOR0.43374114
64GSK3A0.40127664
65MAP3K10.39739616
66MKNK20.39580213
67YES10.37192650
68PRKAA10.35158211
69NEK20.34250668
70ADRBK10.34182204
71SIK20.33773058
72TAOK20.33344806
73CDK70.33264929
74TRIB30.32549189
75MAPK140.32447033
76ERBB40.30679756
77GSK3B0.30117274
78EIF2AK30.29754800
79INSRR0.25591118
80MAP3K30.24976777
81PRKCA0.24333242
82MAP2K10.23384644
83STK30.21890840
84CAMK2G0.21293019
85AKT20.20864567
86CSK0.20538398
87MAPK10.20494532
88ROCK10.20433581
89DAPK20.20327343
90CSNK1A10.20167476
91CAMK10.20032391
92PRKCB0.19426028
93LATS20.18931382
94BRSK10.18192637
95CDK30.18081327
96CDK10.17738433
97IRAK20.17069227
98PIK3CA0.16644837
99JAK10.16636784
100JAK20.16507386

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.12695464
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.90425833
3Systemic lupus erythematosus_Homo sapiens_hsa053223.44701579
4Selenocompound metabolism_Homo sapiens_hsa004503.42404089
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.72877454
6Butanoate metabolism_Homo sapiens_hsa006502.52921140
7Fatty acid biosynthesis_Homo sapiens_hsa000612.51564514
8Alcoholism_Homo sapiens_hsa050342.43917706
9Mineral absorption_Homo sapiens_hsa049782.23177373
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03754557
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91599321
12Dorso-ventral axis formation_Homo sapiens_hsa043201.86614561
13Olfactory transduction_Homo sapiens_hsa047401.84873922
14Linoleic acid metabolism_Homo sapiens_hsa005911.84793227
15Base excision repair_Homo sapiens_hsa034101.67669289
16Phototransduction_Homo sapiens_hsa047441.67410039
17Tryptophan metabolism_Homo sapiens_hsa003801.62697175
18Lysine degradation_Homo sapiens_hsa003101.61340813
19Nitrogen metabolism_Homo sapiens_hsa009101.60202905
20Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.53895950
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49936665
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.49856385
23RNA transport_Homo sapiens_hsa030131.48937740
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.40270742
25Propanoate metabolism_Homo sapiens_hsa006401.39063139
26Calcium signaling pathway_Homo sapiens_hsa040201.35526380
27Salivary secretion_Homo sapiens_hsa049701.35398649
28RNA polymerase_Homo sapiens_hsa030201.31876667
29N-Glycan biosynthesis_Homo sapiens_hsa005101.26899423
30Histidine metabolism_Homo sapiens_hsa003401.25849920
31Glutathione metabolism_Homo sapiens_hsa004801.19664451
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.17662177
33Fanconi anemia pathway_Homo sapiens_hsa034601.17172046
34Ether lipid metabolism_Homo sapiens_hsa005651.16627929
35Glycerolipid metabolism_Homo sapiens_hsa005611.16617297
36Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12065313
37Primary immunodeficiency_Homo sapiens_hsa053401.05388197
38Sulfur relay system_Homo sapiens_hsa041221.01108482
39Fatty acid degradation_Homo sapiens_hsa000711.00623002
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95871561
41Serotonergic synapse_Homo sapiens_hsa047260.94714193
42Nicotine addiction_Homo sapiens_hsa050330.92993126
43Arginine biosynthesis_Homo sapiens_hsa002200.92931902
44Fat digestion and absorption_Homo sapiens_hsa049750.90302734
45cAMP signaling pathway_Homo sapiens_hsa040240.86771132
46Peroxisome_Homo sapiens_hsa041460.86500539
47Arachidonic acid metabolism_Homo sapiens_hsa005900.85512543
48Homologous recombination_Homo sapiens_hsa034400.83869477
49ABC transporters_Homo sapiens_hsa020100.83788932
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82576685
51Taste transduction_Homo sapiens_hsa047420.82409671
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81910440
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78497879
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78057481
55Circadian rhythm_Homo sapiens_hsa047100.75140850
56Fatty acid metabolism_Homo sapiens_hsa012120.71956158
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71250435
58Vitamin digestion and absorption_Homo sapiens_hsa049770.71223109
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70346011
60PPAR signaling pathway_Homo sapiens_hsa033200.69254046
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68651238
62Cholinergic synapse_Homo sapiens_hsa047250.68272650
63Caffeine metabolism_Homo sapiens_hsa002320.67794919
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.67427896
65Proteasome_Homo sapiens_hsa030500.66776846
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66173429
67Morphine addiction_Homo sapiens_hsa050320.64974217
68Viral carcinogenesis_Homo sapiens_hsa052030.64161855
69Retinol metabolism_Homo sapiens_hsa008300.63462959
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59854531
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59218515
72Chemical carcinogenesis_Homo sapiens_hsa052040.57941507
73TNF signaling pathway_Homo sapiens_hsa046680.57735295
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57549923
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57009537
76Fructose and mannose metabolism_Homo sapiens_hsa000510.56157282
77Ovarian steroidogenesis_Homo sapiens_hsa049130.55644229
78Arginine and proline metabolism_Homo sapiens_hsa003300.52811542
79Nucleotide excision repair_Homo sapiens_hsa034200.51845767
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50624832
81Metabolic pathways_Homo sapiens_hsa011000.50427745
82Gastric acid secretion_Homo sapiens_hsa049710.49565345
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48127776
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41824666
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.41208233
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39546692
87Oxytocin signaling pathway_Homo sapiens_hsa049210.39038719
88Bile secretion_Homo sapiens_hsa049760.38744056
89Pyrimidine metabolism_Homo sapiens_hsa002400.37883170
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35665320
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.35039051
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.33972877
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32803538
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.32500222
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31536900
96Basal transcription factors_Homo sapiens_hsa030220.31072389
97T cell receptor signaling pathway_Homo sapiens_hsa046600.30976389
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30330929
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29200067
100Insulin resistance_Homo sapiens_hsa049310.26141055

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