TTLL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)8.73329246
2fusion of sperm to egg plasma membrane (GO:0007342)8.05498226
3negative regulation of complement activation (GO:0045916)7.69439716
4cell wall macromolecule metabolic process (GO:0044036)7.56688324
5cell wall macromolecule catabolic process (GO:0016998)7.56688324
6acrosome assembly (GO:0001675)7.54905120
7acrosome reaction (GO:0007340)7.53954673
8multicellular organism reproduction (GO:0032504)6.88831706
9sperm-egg recognition (GO:0035036)6.85316032
10negative regulation of protein activation cascade (GO:2000258)6.44441039
11cell-cell recognition (GO:0009988)6.33537976
12reproduction (GO:0000003)6.14729562
13spermatid development (GO:0007286)6.13004324
14response to pheromone (GO:0019236)6.11690577
15binding of sperm to zona pellucida (GO:0007339)6.07383254
16plasma membrane fusion (GO:0045026)5.93890347
17epithelial cilium movement (GO:0003351)5.81660723
18motile cilium assembly (GO:0044458)5.79455858
19positive regulation of respiratory burst (GO:0060267)5.63909189
20cilium or flagellum-dependent cell motility (GO:0001539)5.60977813
21negative regulation of humoral immune response (GO:0002921)5.38226699
22axonemal dynein complex assembly (GO:0070286)5.33829571
23cellular ketone body metabolic process (GO:0046950)5.26965639
24regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.10253479
25behavioral response to nicotine (GO:0035095)5.03756385
26single fertilization (GO:0007338)5.03057304
27sperm capacitation (GO:0048240)4.95461974
28cilium movement (GO:0003341)4.67261461
29ketone body metabolic process (GO:1902224)4.63652210
30organic cation transport (GO:0015695)4.51198374
31DNA deamination (GO:0045006)4.44757084
32embryonic digestive tract development (GO:0048566)4.29546305
33positive regulation of macrophage activation (GO:0043032)4.28700542
34protein polyglutamylation (GO:0018095)4.27844142
35detection of molecule of bacterial origin (GO:0032490)4.26755665
36piRNA metabolic process (GO:0034587)4.24574272
37hydrogen peroxide catabolic process (GO:0042744)4.22182073
38response to histamine (GO:0034776)4.20867989
39regulation of dendritic cell antigen processing and presentation (GO:0002604)4.11966018
40single strand break repair (GO:0000012)4.10187179
41regulation of cilium movement (GO:0003352)4.08564445
42fertilization (GO:0009566)4.04991955
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04203634
44spermatogenesis (GO:0007283)3.98810771
45negative regulation of mast cell activation (GO:0033004)3.96930699
46neurotransmitter catabolic process (GO:0042135)3.96871753
47male gamete generation (GO:0048232)3.96722330
48negative regulation of telomere maintenance (GO:0032205)3.90524442
49renal absorption (GO:0070293)3.82390527
50regulation of action potential (GO:0098900)3.69165482
51gamete generation (GO:0007276)3.58987251
52sexual reproduction (GO:0019953)3.55372059
53response to hydroperoxide (GO:0033194)3.50701375
54negative regulation of inclusion body assembly (GO:0090084)3.47534736
55opsonization (GO:0008228)3.46320206
56cellular hyperosmotic response (GO:0071474)3.45352591
57male meiosis (GO:0007140)3.45301581
58platelet dense granule organization (GO:0060155)3.44897904
59detection of light stimulus involved in visual perception (GO:0050908)3.43455620
60detection of light stimulus involved in sensory perception (GO:0050962)3.43455620
61L-fucose catabolic process (GO:0042355)3.43140189
62fucose catabolic process (GO:0019317)3.43140189
63L-fucose metabolic process (GO:0042354)3.43140189
64detection of external biotic stimulus (GO:0098581)3.41180396
65synaptonemal complex organization (GO:0070193)3.40166645
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39962556
67establishment of protein localization to Golgi (GO:0072600)3.39261664
68synaptonemal complex assembly (GO:0007130)3.38986101
69protein targeting to Golgi (GO:0000042)3.37394562
70leukocyte migration involved in inflammatory response (GO:0002523)3.37240136
71negative regulation of sodium ion transport (GO:0010766)3.33995599
72calcium ion-dependent exocytosis (GO:0017156)3.33643425
73NIK/NF-kappaB signaling (GO:0038061)3.33214639
74kynurenine metabolic process (GO:0070189)3.30249532
75germ cell development (GO:0007281)3.27755054
76regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.27366370
77water-soluble vitamin biosynthetic process (GO:0042364)3.27049115
78cellular process involved in reproduction in multicellular organism (GO:0022412)3.25810484
79positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.19421743
80seminiferous tubule development (GO:0072520)3.16459391
81cAMP catabolic process (GO:0006198)3.15945098
82interferon-gamma secretion (GO:0072643)3.15900891
83positive regulation of p38MAPK cascade (GO:1900745)3.14666702
84cell recognition (GO:0008037)3.14280891
85glycerophospholipid catabolic process (GO:0046475)3.14090153
86pyrimidine nucleobase catabolic process (GO:0006208)3.11165239
87glycerol ether metabolic process (GO:0006662)3.10903926
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.10768631
89interferon-gamma production (GO:0032609)3.10341400
90regulation of granulocyte chemotaxis (GO:0071622)3.09141682
91tryptophan catabolic process (GO:0006569)3.08113565
92indole-containing compound catabolic process (GO:0042436)3.08113565
93indolalkylamine catabolic process (GO:0046218)3.08113565
94positive regulation of granulocyte chemotaxis (GO:0071624)3.05011875
95detection of biotic stimulus (GO:0009595)3.03702458
96detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.00442924
97positive regulation of fatty acid transport (GO:2000193)2.99990301
98angiotensin maturation (GO:0002003)2.99537707
99axoneme assembly (GO:0035082)2.99286210
100cellular response to cadmium ion (GO:0071276)2.98097204
101neuronal action potential (GO:0019228)2.97036697
102regulation of complement activation (GO:0030449)2.96782741
103regulation of microtubule-based movement (GO:0060632)2.96428707
104nephron tubule morphogenesis (GO:0072078)2.95812290
105nephron epithelium morphogenesis (GO:0072088)2.95812290
106macrophage activation involved in immune response (GO:0002281)2.95389237
107detection of bacterium (GO:0016045)2.95375184
108membrane depolarization during action potential (GO:0086010)2.93741069
109protein localization to Golgi apparatus (GO:0034067)2.93558866
110multicellular organismal reproductive process (GO:0048609)2.93494271
111positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.93042536
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.91227336
113DNA methylation involved in gamete generation (GO:0043046)2.90749384
114RNA destabilization (GO:0050779)2.88230590
115regulation of mononuclear cell migration (GO:0071675)2.87706819
116microtubule depolymerization (GO:0007019)2.85142359
117negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.85062244
118detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83733093
119positive regulation of antigen processing and presentation (GO:0002579)2.82157493
120ether metabolic process (GO:0018904)2.81681712
121gamma-aminobutyric acid transport (GO:0015812)2.81680836
122regulation of lipoprotein particle clearance (GO:0010984)2.81635896
123regulation of telomere maintenance (GO:0032204)2.80696479
124nucleobase catabolic process (GO:0046113)2.80680581
125negative regulation of bone resorption (GO:0045779)2.79413636
126glucocorticoid biosynthetic process (GO:0006704)2.77285230
127regulation of inclusion body assembly (GO:0090083)2.76859926
128kidney morphogenesis (GO:0060993)2.76616615
129hydrogen peroxide metabolic process (GO:0042743)2.76558139
130somite development (GO:0061053)2.76486009
131protein localization to cilium (GO:0061512)2.76124958
132detection of other organism (GO:0098543)2.74478933
133retinal cone cell development (GO:0046549)2.73830656
134cyclic nucleotide catabolic process (GO:0009214)2.73283585
135alditol metabolic process (GO:0019400)2.72946601
136regulation of protein activation cascade (GO:2000257)2.72578873
137ventricular system development (GO:0021591)2.71242806
138protein-cofactor linkage (GO:0018065)2.70705508
139indolalkylamine metabolic process (GO:0006586)2.70528081
140tryptophan metabolic process (GO:0006568)2.66030139
141membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65744940
142response to arsenic-containing substance (GO:0046685)2.64381929
143adhesion of symbiont to host cell (GO:0044650)2.63627789
144virion attachment to host cell (GO:0019062)2.63627789
145proline transport (GO:0015824)2.62964935
146spermatid nucleus differentiation (GO:0007289)2.62866392
147positive regulation of action potential (GO:0045760)2.62202687
148Leydig cell differentiation (GO:0033327)2.61179183
149behavioral response to ethanol (GO:0048149)2.59121102
150alanine transport (GO:0032328)2.54783428
151detection of chemical stimulus involved in sensory perception (GO:0050907)2.54684034
152positive regulation of hair follicle development (GO:0051798)2.54273589
153positive regulation of hair cycle (GO:0042635)2.54273589
154microtubule severing (GO:0051013)2.53097346
155regulation of respiratory burst (GO:0060263)2.52986229
156response to magnesium ion (GO:0032026)2.51641900
157mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51546141
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.51546141
159NADH dehydrogenase complex assembly (GO:0010257)2.51546141
160arginine catabolic process (GO:0006527)2.51112539
161glycerol metabolic process (GO:0006071)2.50994698
162cilium organization (GO:0044782)2.50923987
163negative regulation of interleukin-1 beta production (GO:0032691)2.48779568
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.48310620
165ATP synthesis coupled proton transport (GO:0015986)2.48310620
166protein K11-linked deubiquitination (GO:0035871)2.47900137
167neurofilament cytoskeleton organization (GO:0060052)2.47739417
168positive regulation of icosanoid secretion (GO:0032305)2.45500247
169reflex (GO:0060004)2.45345726
170cilium assembly (GO:0042384)2.44605259
171primary amino compound metabolic process (GO:1901160)2.44044461
172adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.43845500
173centriole replication (GO:0007099)2.43303288

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.45916550
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.06219521
3EZH2_22144423_ChIP-Seq_EOC_Human3.02488093
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75097251
5CTBP1_25329375_ChIP-Seq_LNCAP_Human2.37421557
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.18823044
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17353758
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16143987
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13516617
10GBX2_23144817_ChIP-Seq_PC3_Human2.07807165
11VDR_22108803_ChIP-Seq_LS180_Human2.02339570
12FUS_26573619_Chip-Seq_HEK293_Human2.00900046
13ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93979965
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89067606
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84770438
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81231597
17DROSHA_22980978_ChIP-Seq_HELA_Human1.76760010
18P300_19829295_ChIP-Seq_ESCs_Human1.76599469
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76392637
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74405225
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69508734
22IGF1R_20145208_ChIP-Seq_DFB_Human1.68539515
23ER_23166858_ChIP-Seq_MCF-7_Human1.67894689
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62882885
25STAT1_17558387_ChIP-Seq_HELA_Human1.59538897
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.59422106
27IRF1_19129219_ChIP-ChIP_H3396_Human1.59113133
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.57574918
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54160395
30GATA3_21878914_ChIP-Seq_MCF-7_Human1.53006628
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52313716
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50555277
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.46130882
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.44957633
35NANOG_20526341_ChIP-Seq_ESCs_Human1.44294782
36TAF15_26573619_Chip-Seq_HEK293_Human1.43747843
37AR_25329375_ChIP-Seq_VCAP_Human1.41966747
38TP53_22573176_ChIP-Seq_HFKS_Human1.41517550
39ERA_21632823_ChIP-Seq_H3396_Human1.39557889
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.39062266
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39062266
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36892772
43PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.36477885
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36166020
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36158617
46* STAT3_23295773_ChIP-Seq_U87_Human1.32082614
47MYC_19829295_ChIP-Seq_ESCs_Human1.31084493
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30263973
49ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29876334
50NANOG_19829295_ChIP-Seq_ESCs_Human1.29586368
51SOX2_19829295_ChIP-Seq_ESCs_Human1.29586368
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28772790
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28304903
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27583867
55TAF2_19829295_ChIP-Seq_ESCs_Human1.27578430
56SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27184377
57BCAT_22108803_ChIP-Seq_LS180_Human1.26342957
58* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24799193
59* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24797670
60RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24705867
61SMAD4_21799915_ChIP-Seq_A2780_Human1.24540350
62FOXH1_21741376_ChIP-Seq_EPCs_Human1.23303739
63RUNX2_22187159_ChIP-Seq_PCA_Human1.22731987
64* KDM2B_26808549_Chip-Seq_REH_Human1.21882445
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.21648596
66TCF4_23295773_ChIP-Seq_U87_Human1.21646368
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21573785
68GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20313346
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.20149097
70EWS_26573619_Chip-Seq_HEK293_Human1.19637209
71RNF2_27304074_Chip-Seq_NSC_Mouse1.19507184
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.18913213
73HOXB7_26014856_ChIP-Seq_BT474_Human1.18797899
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18781711
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18590494
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18457369
77NCOR_22424771_ChIP-Seq_293T_Human1.18024404
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.17399281
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16794908
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16021557
81AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15796662
82* OCT4_20526341_ChIP-Seq_ESCs_Human1.15564486
83CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15043252
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.14425012
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13521375
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12720104
87NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12551498
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12403257
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12309249
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12175808
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12004367
92CBP_20019798_ChIP-Seq_JUKART_Human1.12004367
93IRF8_27001747_Chip-Seq_BMDM_Mouse1.11879649
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11079856
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10412508
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10003158
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.09847498
98FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09770657
99TCF4_22108803_ChIP-Seq_LS180_Human1.09374740
100AR_20517297_ChIP-Seq_VCAP_Human1.09271793
101VDR_24787735_ChIP-Seq_THP-1_Human1.09129984
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.09105344
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.09020412
104FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08653135
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08206327
106ZNF274_21170338_ChIP-Seq_K562_Hela1.07399212
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07358315
108RAC3_21632823_ChIP-Seq_H3396_Human1.05477314
109REST_21632747_ChIP-Seq_MESCs_Mouse1.04781428
110THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04622952
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.03508728
112FOXH1_21741376_ChIP-Seq_ESCs_Human1.03311143
113SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03013810
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02512084
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.02186183
116TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02117983
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01811813
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01748887
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01619224
120SOX2_22085726_ChIP-Seq_NPCs_Mouse1.01541425
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00725431
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99981559
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99981559
124MYC_18940864_ChIP-ChIP_HL60_Human0.99552869
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99374037
126SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98880188
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.97999365
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97439370
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97317400
130TCF4_18268006_ChIP-ChIP_LS174T_Human0.96303633
131CTCF_27219007_Chip-Seq_Bcells_Human0.95132364
132LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94992534
133* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.94940777
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94337936
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93889107
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93398888
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.92976852
138STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92786166
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91469863
140EP300_21415370_ChIP-Seq_HL-1_Mouse0.89933576
141GF1_26923725_Chip-Seq_HPCs_Mouse0.89837955
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89535494
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89489079
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88807152
145PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87814821
146SPI1_26923725_Chip-Seq_HPCs_Mouse0.87153380
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86904853
148CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86847697
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86553347
150OCT4_21477851_ChIP-Seq_ESCs_Mouse0.86179920
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.86033716
152EGR1_23403033_ChIP-Seq_LIVER_Mouse0.85292108
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85028328
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.84990123
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.84937244
156AHR_22903824_ChIP-Seq_MCF-7_Human0.84451177
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84383051
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84256668
159CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84220576
160EGR1_19032775_ChIP-ChIP_M12_Human0.83478668
161PIAS1_25552417_ChIP-Seq_VCAP_Human0.83288885
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.83060622
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.82825244
164SOX2_27498859_Chip-Seq_STOMACH_Mouse0.82773127
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.82198357
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82196797
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.81782234
168CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80736088
169GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80293296
170ESET_19884257_ChIP-Seq_ESCs_Mouse0.78949545
171PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78870718
172MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78806433
173GATA3_21867929_ChIP-Seq_CD8_Mouse0.78169595
174OCT4_18555785_Chip-Seq_ESCs_Mouse0.78038503
175TBL1_22424771_ChIP-Seq_293T_Human0.77819028
176CDX2_22108803_ChIP-Seq_LS180_Human0.77764998

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.22956624
2MP0002254_reproductive_system_inflammat7.96999283
3MP0008877_abnormal_DNA_methylation4.06408729
4MP0002876_abnormal_thyroid_physiology3.97034779
5MP0000685_abnormal_immune_system3.77988666
6MP0001346_abnormal_lacrimal_gland2.99986344
7MP0000566_synostosis2.94142467
8MP0000604_amyloidosis2.94121455
9MP0001542_abnormal_bone_strength2.83162563
10MP0005645_abnormal_hypothalamus_physiol2.74351636
11MP0003787_abnormal_imprinting2.66289120
12MP0000569_abnormal_digit_pigmentation2.64732772
13MP0004510_myositis2.62904516
14MP0003879_abnormal_hair_cell2.59495441
15MP0003698_abnormal_male_reproductive2.51327545
16MP0002102_abnormal_ear_morphology2.46968256
17MP0003122_maternal_imprinting2.44367706
18MP0003011_delayed_dark_adaptation2.40150603
19MP0001348_abnormal_lacrimal_gland2.37706637
20MP0005551_abnormal_eye_electrophysiolog2.36889166
21MP0001968_abnormal_touch/_nociception2.16381687
22MP0003283_abnormal_digestive_organ2.15825571
23MP0001929_abnormal_gametogenesis2.15292468
24MP0006082_CNS_inflammation2.05464347
25MP0006072_abnormal_retinal_apoptosis2.04848309
26MP0001986_abnormal_taste_sensitivity2.03690012
27MP0002160_abnormal_reproductive_system1.95541720
28MP0005310_abnormal_salivary_gland1.95411331
29MP0002653_abnormal_ependyma_morphology1.89553540
30MP0005084_abnormal_gallbladder_morpholo1.89469688
31MP0009745_abnormal_behavioral_response1.87790026
32MP0009046_muscle_twitch1.87717036
33MP0002272_abnormal_nervous_system1.85745988
34MP0005360_urolithiasis1.85509504
35MP0002877_abnormal_melanocyte_morpholog1.83848461
36MP0008438_abnormal_cutaneous_collagen1.82727462
37MP0001486_abnormal_startle_reflex1.82111485
38MP0001835_abnormal_antigen_presentation1.74341126
39MP0006276_abnormal_autonomic_nervous1.72928946
40MP0005379_endocrine/exocrine_gland_phen1.69117283
41MP0004142_abnormal_muscle_tone1.68352433
42MP0008872_abnormal_physiological_respon1.67385697
43MP0005253_abnormal_eye_physiology1.67177294
44MP0003567_abnormal_fetal_cardiomyocyte1.65197341
45MP0002837_dystrophic_cardiac_calcinosis1.65145140
46MP0003880_abnormal_central_pattern1.63570072
47MP0010234_abnormal_vibrissa_follicle1.55831155
48MP0003121_genomic_imprinting1.55617924
49MP0000681_abnormal_thyroid_gland1.53484766
50MP0003646_muscle_fatigue1.53239274
51MP0005646_abnormal_pituitary_gland1.51955960
52MP0005647_abnormal_sex_gland1.50292032
53MP0003195_calcinosis1.45947292
54MP0004885_abnormal_endolymph1.41965103
55MP0002572_abnormal_emotion/affect_behav1.41196514
56MP0002733_abnormal_thermal_nociception1.38694613
57MP0002064_seizures1.37522800
58MP0002557_abnormal_social/conspecific_i1.35008673
59MP0001970_abnormal_pain_threshold1.33184643
60MP0006054_spinal_hemorrhage1.33122591
61MP0002735_abnormal_chemical_nociception1.31005452
62MP0002736_abnormal_nociception_after1.30825574
63MP0001440_abnormal_grooming_behavior1.30741982
64MP0005423_abnormal_somatic_nervous1.30596599
65MP0004147_increased_porphyrin_level1.30422406
66MP0005670_abnormal_white_adipose1.29856642
67MP0001984_abnormal_olfaction1.28540730
68MP0002161_abnormal_fertility/fecundity1.26862061
69MP0004742_abnormal_vestibular_system1.26743684
70MP0005164_abnormal_response_to1.25948781
71MP0002998_abnormal_bone_remodeling1.25251981
72MP0002163_abnormal_gland_morphology1.24286897
73MP0005623_abnormal_meninges_morphology1.23167616
74MP0001905_abnormal_dopamine_level1.22243693
75MP0004133_heterotaxia1.22143799
76MP0003635_abnormal_synaptic_transmissio1.21467654
77MP0002067_abnormal_sensory_capabilities1.20153564
78MP0002063_abnormal_learning/memory/cond1.18256629
79MP0006292_abnormal_olfactory_placode1.12501545
80MP0002734_abnormal_mechanical_nocicepti1.12104039
81MP0010678_abnormal_skin_adnexa1.10998365
82MP0005377_hearing/vestibular/ear_phenot1.10544944
83MP0003878_abnormal_ear_physiology1.10544944
84MP0001919_abnormal_reproductive_system1.10032342
85MP0002971_abnormal_brown_adipose1.09828641
86MP0002210_abnormal_sex_determination1.09537309
87MP0004859_abnormal_synaptic_plasticity1.06679020
88MP0009785_altered_susceptibility_to1.06423077
89MP0009840_abnormal_foam_cell1.06184850
90MP0002928_abnormal_bile_duct1.04513713
91MP0000383_abnormal_hair_follicle1.03705223
92MP0004043_abnormal_pH_regulation1.02357615
93MP0000230_abnormal_systemic_arterial1.01823451
94MP0003137_abnormal_impulse_conducting1.00590433
95MP0002229_neurodegeneration0.99148485
96MP0001666_abnormal_nutrient_absorption0.96697068
97MP0005365_abnormal_bile_salt0.96599691
98MP0005167_abnormal_blood-brain_barrier0.95718462
99MP0001765_abnormal_ion_homeostasis0.95041833
100MP0004924_abnormal_behavior0.94982462
101MP0005386_behavior/neurological_phenoty0.94982462
102MP0001873_stomach_inflammation0.92195352
103MP0008995_early_reproductive_senescence0.91420265
104MP0004145_abnormal_muscle_electrophysio0.91270221
105MP0004858_abnormal_nervous_system0.89816147
106MP0005275_abnormal_skin_tensile0.88755387
107MP0001501_abnormal_sleep_pattern0.88560140
108MP0005195_abnormal_posterior_eye0.88455374
109MP0001963_abnormal_hearing_physiology0.88301379
110MP0003172_abnormal_lysosome_physiology0.88045637
111MP0000778_abnormal_nervous_system0.87349646
112MP0003718_maternal_effect0.87200360
113MP0002752_abnormal_somatic_nervous0.86249300
114MP0000538_abnormal_urinary_bladder0.84314047
115MP0002822_catalepsy0.84099413
116MP0010329_abnormal_lipoprotein_level0.83070105
117MP0001145_abnormal_male_reproductive0.83001540
118MP0002184_abnormal_innervation0.82961859
119MP0002796_impaired_skin_barrier0.82857825
120MP0000026_abnormal_inner_ear0.82789051
121MP0001533_abnormal_skeleton_physiology0.82250993
122MP0003183_abnormal_peptide_metabolism0.80488673
123MP0001790_abnormal_immune_system0.79669627
124MP0005387_immune_system_phenotype0.79669627
125MP0000955_abnormal_spinal_cord0.77654242
126MP0006138_congestive_heart_failure0.76455054
127MP0003091_abnormal_cell_migration0.76124670
128MP0005389_reproductive_system_phenotype0.76028357
129MP0002882_abnormal_neuron_morphology0.74114497
130MP0003950_abnormal_plasma_membrane0.73808024
131MP0003119_abnormal_digestive_system0.73281299
132MP0008875_abnormal_xenobiotic_pharmacok0.73140375
133MP0000372_irregular_coat_pigmentation0.72927731
134MP0002419_abnormal_innate_immunity0.71741660
135MP0003329_amyloid_beta_deposits0.70815620
136MP0002269_muscular_atrophy0.70178864
137MP0001485_abnormal_pinna_reflex0.68992261
138MP0000653_abnormal_sex_gland0.68544493
139MP0009115_abnormal_fat_cell0.68494377
140MP0001764_abnormal_homeostasis0.67800097
141MP0004883_abnormal_blood_vessel0.67730605
142MP0003638_abnormal_response/metabolism_0.67380950
143MP0005636_abnormal_mineral_homeostasis0.66574896
144MP0000003_abnormal_adipose_tissue0.65807287
145MP0005671_abnormal_response_to0.63388217
146MP0000049_abnormal_middle_ear0.63087841
147MP0003453_abnormal_keratinocyte_physiol0.62657550
148MP0004947_skin_inflammation0.61543272
149MP0000343_altered_response_to0.60518937
150MP0004036_abnormal_muscle_relaxation0.60482675
151MP0001845_abnormal_inflammatory_respons0.60224815
152MP0009643_abnormal_urine_homeostasis0.59762716
153MP0002693_abnormal_pancreas_physiology0.59689092
154MP0005503_abnormal_tendon_morphology0.59597576
155MP0005448_abnormal_energy_balance0.58233553
156MP0000427_abnormal_hair_cycle0.56825136
157MP0003252_abnormal_bile_duct0.56378531
158MP0000470_abnormal_stomach_morphology0.56273628
159MP0005085_abnormal_gallbladder_physiolo0.55828106
160MP0000858_altered_metastatic_potential0.55777555
161MP0002139_abnormal_hepatobiliary_system0.54831304
162MP0008469_abnormal_protein_level0.54703573
163MP0001299_abnormal_eye_distance/0.53989219
164MP0005025_abnormal_response_to0.53284162
165MP0002138_abnormal_hepatobiliary_system0.53037255
166MP0000613_abnormal_salivary_gland0.52797102
167MP0005376_homeostasis/metabolism_phenot0.52295452
168MP0002909_abnormal_adrenal_gland0.51465584
169MP0000639_abnormal_adrenal_gland0.50576069
170MP0001663_abnormal_digestive_system0.50295622
171MP0002115_abnormal_skeleton_extremities0.49448182

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)7.47416955
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.47416955
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.01073793
4Hydroxyprolinuria (HP:0003080)6.97134659
5Abnormality of proline metabolism (HP:0010907)6.97134659
6Absent frontal sinuses (HP:0002688)5.65098190
7Spondylolisthesis (HP:0003302)4.86944946
8Abnormal respiratory motile cilium physiology (HP:0012261)4.72065302
9Abnormal respiratory motile cilium morphology (HP:0005938)4.70217992
10Abnormal respiratory epithelium morphology (HP:0012253)4.70217992
11Chronic bronchitis (HP:0004469)4.52256109
12Persistence of primary teeth (HP:0006335)4.51170393
13Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46129543
14Pancreatic cysts (HP:0001737)4.27835677
15Osteolytic defects of the phalanges of the hand (HP:0009771)4.23225034
16Osteolytic defects of the hand bones (HP:0009699)4.23225034
17Nasal polyposis (HP:0100582)4.19252315
18Infertility (HP:0000789)4.18506805
19Pancreatic fibrosis (HP:0100732)4.12109146
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.05340978
21Keratoconjunctivitis (HP:0001096)3.90260320
22Chronic hepatic failure (HP:0100626)3.86088748
23Decreased circulating renin level (HP:0003351)3.72251416
24Congenital stationary night blindness (HP:0007642)3.68929146
25True hermaphroditism (HP:0010459)3.68666368
26Abnormal ciliary motility (HP:0012262)3.59811292
27Systemic lupus erythematosus (HP:0002725)3.59406249
28Rhinitis (HP:0012384)3.57515556
29Right ventricular cardiomyopathy (HP:0011663)3.46212167
30Attenuation of retinal blood vessels (HP:0007843)3.38571916
31Abnormal drinking behavior (HP:0030082)3.35779587
32Polydipsia (HP:0001959)3.35779587
33Tongue fasciculations (HP:0001308)3.33905790
34Abnormality of the nasal mucosa (HP:0000433)3.33016522
35Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.28115723
36Abnormality of the frontal sinuses (HP:0002687)3.27646723
37Type II lissencephaly (HP:0007260)3.14218696
38Male infertility (HP:0003251)3.11855752
39Muscle fibrillation (HP:0010546)3.04285279
40Hyperphosphatemia (HP:0002905)2.99693329
41Upper limb muscle weakness (HP:0003484)2.99273245
42Myositis (HP:0100614)2.97074270
43Ridged nail (HP:0001807)2.94362203
44Abnormal rod and cone electroretinograms (HP:0008323)2.92725997
45Abnormality of the renal cortex (HP:0011035)2.87804897
46Humeroradial synostosis (HP:0003041)2.87610555
47Synostosis involving the elbow (HP:0003938)2.87610555
48Cystic liver disease (HP:0006706)2.87442390
49Pendular nystagmus (HP:0012043)2.86465978
50Type I diabetes mellitus (HP:0100651)2.85030404
51Polyuria (HP:0000103)2.82598229
52Abolished electroretinogram (ERG) (HP:0000550)2.80475738
53Abnormality of the neuromuscular junction (HP:0003398)2.70594802
54Fatigable weakness (HP:0003473)2.70594802
55Stomach cancer (HP:0012126)2.70285864
56Chronic mucocutaneous candidiasis (HP:0002728)2.69022277
57Recurrent cutaneous fungal infections (HP:0011370)2.69022277
58Bronchitis (HP:0012387)2.65354883
59Medial flaring of the eyebrow (HP:0010747)2.63767377
60Eczematoid dermatitis (HP:0000976)2.59346132
61Bony spicule pigmentary retinopathy (HP:0007737)2.58688888
62Sclerocornea (HP:0000647)2.58639566
63Choroideremia (HP:0001139)2.55313914
64Abnormal urine output (HP:0012590)2.54168606
65Orchitis (HP:0100796)2.51927294
66Hypoplasia of the uterus (HP:0000013)2.51683644
67Abnormal biliary tract physiology (HP:0012439)2.51423895
68Bile duct proliferation (HP:0001408)2.51423895
69Inability to walk (HP:0002540)2.50928530
70Abnormal pupillary function (HP:0007686)2.49670911
71Optic neuritis (HP:0100653)2.49275172
72Retrobulbar optic neuritis (HP:0100654)2.49275172
73Polyphagia (HP:0002591)2.48508496
74Type 2 muscle fiber atrophy (HP:0003554)2.46475631
75Decreased central vision (HP:0007663)2.46469419
76Gait imbalance (HP:0002141)2.46102204
77Amelogenesis imperfecta (HP:0000705)2.44827065
78Congenital malformation of the right heart (HP:0011723)2.44578189
79Double outlet right ventricle (HP:0001719)2.44578189
80Absent rod-and cone-mediated responses on ERG (HP:0007688)2.42888231
81Abnormality of renal excretion (HP:0011036)2.42146597
82Increased purine levels (HP:0004368)2.39748292
83Hyperuricemia (HP:0002149)2.39748292
84Cervical subluxation (HP:0003308)2.35063202
85Progressive cerebellar ataxia (HP:0002073)2.34088782
86Nephronophthisis (HP:0000090)2.33848189
87Aplasia/hypoplasia of the uterus (HP:0008684)2.33523983
88Ileus (HP:0002595)2.32179822
89Delayed closure of the anterior fontanelle (HP:0001476)2.32100490
90Renal cortical cysts (HP:0000803)2.26424153
91Abnormality of renin-angiotensin system (HP:0000847)2.26183213
92Bronchiectasis (HP:0002110)2.26027316
93Hyperventilation (HP:0002883)2.25077010
94Progressive inability to walk (HP:0002505)2.23615334
95Hyporeflexia of lower limbs (HP:0002600)2.23386555
96Cerebellar dysplasia (HP:0007033)2.21337755
97Congenital primary aphakia (HP:0007707)2.18961165
98Severe visual impairment (HP:0001141)2.18828634
99Large for gestational age (HP:0001520)2.17913508
100Keratoconus (HP:0000563)2.16018937
101Increased corneal curvature (HP:0100692)2.16018937
102Weak cry (HP:0001612)2.15846220
103Mucopolysacchariduria (HP:0008155)2.14473406
104Urinary glycosaminoglycan excretion (HP:0003541)2.14473406
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13246563
106Decreased muscle mass (HP:0003199)2.13235463
107Male pseudohermaphroditism (HP:0000037)2.12313479
108Concave nail (HP:0001598)2.12236011
109Aplasia/Hypoplasia of the tongue (HP:0010295)2.10726167
110Malnutrition (HP:0004395)2.10288767
111Myokymia (HP:0002411)2.09364973
112Lissencephaly (HP:0001339)2.09155775
113Glycosuria (HP:0003076)2.09129816
114Abnormality of urine glucose concentration (HP:0011016)2.09129816
115Easy fatigability (HP:0003388)2.08404234
116Methylmalonic acidemia (HP:0002912)2.07852015
117Ulnar deviation of the wrist (HP:0003049)2.07501716
118Abnormality of calcium-phosphate metabolism (HP:0100530)2.07052583
119Occipital encephalocele (HP:0002085)2.06933631
120Hypoplasia of dental enamel (HP:0006297)2.06889122
121Autoimmune thrombocytopenia (HP:0001973)2.06592759
122Abnormality of purine metabolism (HP:0004352)2.06273799
123Clumsiness (HP:0002312)2.06264423
124Muscle fiber atrophy (HP:0100295)2.04586352
125Anencephaly (HP:0002323)2.04432938
126Agitation (HP:0000713)2.03782036
127Failure to thrive in infancy (HP:0001531)2.01061037
128Abnormality of the gastric mucosa (HP:0004295)2.00809392
129Abnormality of dental color (HP:0011073)1.99818204
130Hypobetalipoproteinemia (HP:0003563)1.99633826
131Broad-based gait (HP:0002136)1.99372075
132Tetraparesis (HP:0002273)1.96856758
133Nephrogenic diabetes insipidus (HP:0009806)1.95491883
134Ketosis (HP:0001946)1.94013635
135Hypomagnesemia (HP:0002917)1.93969204
136Congenital hepatic fibrosis (HP:0002612)1.93646209
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90110832
138Abnormality of polysaccharide metabolism (HP:0011012)1.90110832
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90110832
140Mitochondrial inheritance (HP:0001427)1.89545866
141Intestinal atresia (HP:0011100)1.89534689
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.86965130
143Acute necrotizing encephalopathy (HP:0006965)1.86701777
144Genital tract atresia (HP:0001827)1.86701556
145Postaxial foot polydactyly (HP:0001830)1.85524661
146Hypoplasia of the brainstem (HP:0002365)1.85093145
147Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85093145
148Purpura (HP:0000979)1.85015459
149Gaze-evoked nystagmus (HP:0000640)1.83942902
150Methylmalonic aciduria (HP:0012120)1.83809682
151Tubular atrophy (HP:0000092)1.83807407
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.83661751
153Stomatitis (HP:0010280)1.83125645
154Abnormality of the renal medulla (HP:0100957)1.82669317
155Abnormality of macular pigmentation (HP:0008002)1.82283630
156Increased CSF lactate (HP:0002490)1.82032127
157Neurofibrillary tangles (HP:0002185)1.80661539
158Vaginal atresia (HP:0000148)1.80089575
159Keratoconjunctivitis sicca (HP:0001097)1.76647556
1603-Methylglutaconic aciduria (HP:0003535)1.76344335
161Chorioretinal atrophy (HP:0000533)1.76331071
162Furrowed tongue (HP:0000221)1.75942977
163Disproportionate short-trunk short stature (HP:0003521)1.75314685
164Acute encephalopathy (HP:0006846)1.75019407
165Pachygyria (HP:0001302)1.75016965
166Retinal dysplasia (HP:0007973)1.74847747
167Limb dystonia (HP:0002451)1.74711191
168Hyperalaninemia (HP:0003348)1.73705183
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.73705183
170Abnormality of alanine metabolism (HP:0010916)1.73705183
171Optic disc pallor (HP:0000543)1.72502494
172Hypercortisolism (HP:0001578)1.70950802
173Abnormality of midbrain morphology (HP:0002418)1.70717402
174Molar tooth sign on MRI (HP:0002419)1.70717402
175Congenital sensorineural hearing impairment (HP:0008527)1.70438025
176Thickened calvaria (HP:0002684)1.67617720
177Fragile skin (HP:0001030)1.66572058
178Abnormal hemoglobin (HP:0011902)1.66403510
179Asymmetric septal hypertrophy (HP:0001670)1.66237264
180Abnormality of macrophages (HP:0004311)1.65225317
181Tubulointerstitial fibrosis (HP:0005576)1.63975142
182Hyperglycemia (HP:0003074)1.61565714
183Elevated erythrocyte sedimentation rate (HP:0003565)1.59987116
184Recurrent skin infections (HP:0001581)1.58763108
185Aplasia/Hypoplasia of the spleen (HP:0010451)1.58397141
186Recurrent otitis media (HP:0000403)1.58061643
187Abnormality of primary teeth (HP:0006481)1.57371815
188Premature rupture of membranes (HP:0001788)1.56857382
189Tubulointerstitial abnormality (HP:0001969)1.55996149
190Hypodontia (HP:0000668)1.55866825

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.93945941
2PDK44.93255496
3PDK34.93255496
4PDK24.72427171
5MAP4K24.19246312
6DYRK1B4.03934376
7TLK13.96606779
8NME13.42007304
9PRKD33.36629189
10PINK13.25289964
11ICK2.97146597
12MAP3K142.76233892
13ZAK2.64462694
14ADRBK22.62531436
15PLK42.52406721
16WNK32.42801950
17EPHA32.32964754
18TXK2.19278751
19TRIM282.17526060
20MAP3K41.93557346
21IRAK31.86849063
22OXSR11.82335149
23CAMKK21.82325914
24ERN11.81528101
25FRK1.80211226
26TBK11.78549927
27IRAK41.75069481
28ERBB31.74719453
29IRAK11.72425466
30LMTK21.66657725
31PTK2B1.56549521
32BMPR1B1.53754375
33MARK11.50268020
34DYRK31.44582390
35MAP2K71.44233751
36STK381.40527166
37EPHB11.39330617
38MAP3K131.35032159
39ARAF1.32405395
40PAK41.32286597
41CDK191.27582719
42ACVR1B1.26789841
43PHKG11.20609858
44PHKG21.20609858
45PRKG21.17409179
46MST1R1.15310525
47BRAF1.13206891
48IRAK21.11605896
49TAOK31.10854033
50TNIK1.09672938
51DAPK21.06702775
52MAP3K111.04314440
53MAP3K91.03297245
54PDK11.00751211
55PRKCG0.99035939
56PDPK10.98933569
57NTRK30.97560446
58PTK60.96624234
59BMPR20.96532550
60FES0.91202642
61BCKDK0.89751328
62NUAK10.89266243
63EPHA20.85151654
64WNK40.84664593
65FGFR20.83774734
66CAMKK10.83646077
67TYRO30.82385165
68MAP3K100.81600299
69STK390.78047495
70AKT30.77778389
71GRK70.77454599
72MAP3K70.77318770
73TRPM70.77009479
74BMX0.74829384
75LIMK10.74435638
76EPHA40.73140897
77TIE10.71985616
78CSNK1G20.71010396
79ADRBK10.70496696
80EPHB20.69659069
81PRKCH0.68816841
82MARK30.68740917
83PIK3CA0.67635908
84MINK10.67230223
85CASK0.66694454
86BCR0.65783821
87PRKAA20.64883713
88CHUK0.64464428
89MAP2K40.64270142
90PRKCE0.63958119
91PKN10.63929678
92DDR20.63721422
93CSNK1G30.63484571
94MAP3K120.63167752
95STK110.58656975
96IKBKE0.58491909
97PASK0.58465925
98CAMK10.58140079
99STK160.55370876
100TYK20.54991261
101PRKACA0.52806083
102TNK20.52429008
103GRK10.51841211
104CSNK1G10.51417964
105FGFR40.51389160
106CDK30.51266762
107PLK20.51167974
108CAMK2A0.49780874
109CAMK1G0.49597459
110ROCK20.49057488
111PAK10.47533319
112CSNK1A1L0.46762929
113GRK60.44859866
114ROCK10.44495712
115IKBKB0.44357799
116LATS10.44169390
117MATK0.43308685
118CSNK1A10.40480321
119PRKCQ0.40309618
120MYLK0.39715649
121NEK60.37367367
122PTK20.36937223
123KIT0.36834338
124RPS6KA50.36562350
125NTRK20.36411397
126FGFR30.36145658
127MARK20.36097830
128PAK30.35644155
129NEK20.35441078
130SIK20.35303496
131MKNK20.35228324
132PRKG10.34858753
133PRKCA0.34766808
134WNK10.34424882
135CSNK1D0.33913965
136CDC42BPA0.32751964
137TGFBR10.32564604
138PRKCZ0.31454356
139PIK3CG0.31313100
140VRK10.31190859
141STK38L0.31173069
142DYRK1A0.30968055
143MAPKAPK30.29458547
144RPS6KA10.28644570
145NTRK10.28024963
146MAPKAPK50.27436747
147OBSCN0.26365865
148MAP2K20.25013589
149DYRK20.25004206
150INSR0.24591278
151PRKCD0.24533594
152INSRR0.23882565
153MAPK130.23725557
154IGF1R0.23651338
155KSR20.23527012
156EGFR0.23119044
157JAK10.20975249
158EIF2AK20.19843141
159MAPK150.19801151
160FER0.18675806
161SRC0.17980103
162MAP2K60.16732868
163PRKAA10.16591176
164PDGFRA0.16081760
165MTOR0.15503658
166PNCK0.14784163
167SYK0.13679730
168SCYL20.12305728

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.82896422
2Histidine metabolism_Homo sapiens_hsa003403.69406008
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.54738101
4Linoleic acid metabolism_Homo sapiens_hsa005913.22749583
5Glycosaminoglycan degradation_Homo sapiens_hsa005313.18119661
6Fat digestion and absorption_Homo sapiens_hsa049753.09034512
7Phototransduction_Homo sapiens_hsa047443.05419062
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.97439164
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.59894383
10Butanoate metabolism_Homo sapiens_hsa006502.58089724
11Oxidative phosphorylation_Homo sapiens_hsa001902.28312105
12Arachidonic acid metabolism_Homo sapiens_hsa005902.16541320
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.11866784
14Vitamin digestion and absorption_Homo sapiens_hsa049772.11442858
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.03338355
16Nicotine addiction_Homo sapiens_hsa050332.03044233
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.93101643
18Olfactory transduction_Homo sapiens_hsa047401.89741073
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.87841537
20Ether lipid metabolism_Homo sapiens_hsa005651.86720148
21Cardiac muscle contraction_Homo sapiens_hsa042601.85650817
22Sphingolipid metabolism_Homo sapiens_hsa006001.80914513
23Tryptophan metabolism_Homo sapiens_hsa003801.80136434
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.76721578
25Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76644238
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.71919698
27Mineral absorption_Homo sapiens_hsa049781.68126605
28Morphine addiction_Homo sapiens_hsa050321.68072934
29Parkinsons disease_Homo sapiens_hsa050121.62464415
30Nitrogen metabolism_Homo sapiens_hsa009101.61555023
31PPAR signaling pathway_Homo sapiens_hsa033201.59551603
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56573068
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51513081
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50838108
35Glutathione metabolism_Homo sapiens_hsa004801.46055574
36Fatty acid biosynthesis_Homo sapiens_hsa000611.38176591
37Peroxisome_Homo sapiens_hsa041461.37254865
38Galactose metabolism_Homo sapiens_hsa000521.35228279
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.34638848
40Pyruvate metabolism_Homo sapiens_hsa006201.33471277
41Arginine and proline metabolism_Homo sapiens_hsa003301.30094513
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29968688
43Renin-angiotensin system_Homo sapiens_hsa046141.29734996
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.28853573
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28551497
46Caffeine metabolism_Homo sapiens_hsa002321.25236021
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.21330642
48Antigen processing and presentation_Homo sapiens_hsa046121.19133766
49Circadian entrainment_Homo sapiens_hsa047131.16881889
50Phenylalanine metabolism_Homo sapiens_hsa003601.15121271
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13575566
52Osteoclast differentiation_Homo sapiens_hsa043801.13498878
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12726692
54Rheumatoid arthritis_Homo sapiens_hsa053231.12181722
55Pentose and glucuronate interconversions_Homo sapiens_hsa000401.10970795
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10842971
57Lysosome_Homo sapiens_hsa041421.08186415
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07963314
59Insulin secretion_Homo sapiens_hsa049111.07929360
60GABAergic synapse_Homo sapiens_hsa047271.06239251
61Complement and coagulation cascades_Homo sapiens_hsa046101.05259955
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03484816
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.03021600
64Huntingtons disease_Homo sapiens_hsa050161.02315071
65Alzheimers disease_Homo sapiens_hsa050101.01841226
66Glycerolipid metabolism_Homo sapiens_hsa005611.01760078
67Starch and sucrose metabolism_Homo sapiens_hsa005000.99746538
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99669649
69Staphylococcus aureus infection_Homo sapiens_hsa051500.96809605
70Asthma_Homo sapiens_hsa053100.96755925
71Fatty acid metabolism_Homo sapiens_hsa012120.96327918
72Graft-versus-host disease_Homo sapiens_hsa053320.94895117
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94272183
74Regulation of autophagy_Homo sapiens_hsa041400.90924360
75Glutamatergic synapse_Homo sapiens_hsa047240.90806408
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88602661
77Homologous recombination_Homo sapiens_hsa034400.85269130
78Fanconi anemia pathway_Homo sapiens_hsa034600.84725588
79Serotonergic synapse_Homo sapiens_hsa047260.84321493
80Type I diabetes mellitus_Homo sapiens_hsa049400.83040755
81Allograft rejection_Homo sapiens_hsa053300.83037097
82Salivary secretion_Homo sapiens_hsa049700.80385947
83Autoimmune thyroid disease_Homo sapiens_hsa053200.76783926
84beta-Alanine metabolism_Homo sapiens_hsa004100.75951193
85Protein digestion and absorption_Homo sapiens_hsa049740.75521928
86Thyroid hormone synthesis_Homo sapiens_hsa049180.75292163
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74926635
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.74407437
89Apoptosis_Homo sapiens_hsa042100.73766188
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73701187
91Steroid biosynthesis_Homo sapiens_hsa001000.70657424
92Propanoate metabolism_Homo sapiens_hsa006400.70141567
93Basal transcription factors_Homo sapiens_hsa030220.68487981
94African trypanosomiasis_Homo sapiens_hsa051430.67145725
95Fatty acid elongation_Homo sapiens_hsa000620.65520227
96RNA degradation_Homo sapiens_hsa030180.65211258
97Pentose phosphate pathway_Homo sapiens_hsa000300.64791722
98Protein export_Homo sapiens_hsa030600.64666689
99Chemical carcinogenesis_Homo sapiens_hsa052040.64002942
100Bile secretion_Homo sapiens_hsa049760.63867630
101Amphetamine addiction_Homo sapiens_hsa050310.62973885
102Metabolic pathways_Homo sapiens_hsa011000.62320906
103Other glycan degradation_Homo sapiens_hsa005110.60995365
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60753798
105Dorso-ventral axis formation_Homo sapiens_hsa043200.60671392
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59953918
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59192984
108Purine metabolism_Homo sapiens_hsa002300.58300878
109ABC transporters_Homo sapiens_hsa020100.57948940
110RNA polymerase_Homo sapiens_hsa030200.57798836
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57461326
112Ovarian steroidogenesis_Homo sapiens_hsa049130.57214355
113Dopaminergic synapse_Homo sapiens_hsa047280.56668582
114Ras signaling pathway_Homo sapiens_hsa040140.56228287
115Selenocompound metabolism_Homo sapiens_hsa004500.54765660
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53566286
117Gastric acid secretion_Homo sapiens_hsa049710.52922164
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52685576
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51858307
120Fructose and mannose metabolism_Homo sapiens_hsa000510.51763428
121Tuberculosis_Homo sapiens_hsa051520.50303878
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49915568
123Amoebiasis_Homo sapiens_hsa051460.49367163
124Leishmaniasis_Homo sapiens_hsa051400.47899590
125Retinol metabolism_Homo sapiens_hsa008300.47647084
126TNF signaling pathway_Homo sapiens_hsa046680.47326526
127Legionellosis_Homo sapiens_hsa051340.47025422
128Phagosome_Homo sapiens_hsa041450.46377375
129Hematopoietic cell lineage_Homo sapiens_hsa046400.44903943
130Type II diabetes mellitus_Homo sapiens_hsa049300.44436390
131Cholinergic synapse_Homo sapiens_hsa047250.42922891
132Glucagon signaling pathway_Homo sapiens_hsa049220.42391291
133Toxoplasmosis_Homo sapiens_hsa051450.42145807
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41664948
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40118044
136cAMP signaling pathway_Homo sapiens_hsa040240.39732032
137Primary immunodeficiency_Homo sapiens_hsa053400.39415874
138Synaptic vesicle cycle_Homo sapiens_hsa047210.39109323
139Pertussis_Homo sapiens_hsa051330.38842631
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38827659
141Oxytocin signaling pathway_Homo sapiens_hsa049210.38491218
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.37895645
143Taste transduction_Homo sapiens_hsa047420.37298714
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36692651
145Prion diseases_Homo sapiens_hsa050200.36515399
146Renin secretion_Homo sapiens_hsa049240.35848995
147Fatty acid degradation_Homo sapiens_hsa000710.35616985
148Arginine biosynthesis_Homo sapiens_hsa002200.34783240
149Sulfur relay system_Homo sapiens_hsa041220.34113063
150Collecting duct acid secretion_Homo sapiens_hsa049660.30045338
151Vibrio cholerae infection_Homo sapiens_hsa051100.28753166
152Salmonella infection_Homo sapiens_hsa051320.27748890
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.27326843
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27153325
155Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24311851
156Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22278602
157Sulfur metabolism_Homo sapiens_hsa009200.21879305
158Melanoma_Homo sapiens_hsa052180.21654139
159Calcium signaling pathway_Homo sapiens_hsa040200.21502271

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »