TTLL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)7.23274412
2axonemal dynein complex assembly (GO:0070286)7.09015927
3cilium or flagellum-dependent cell motility (GO:0001539)6.49003240
4epithelial cilium movement (GO:0003351)6.22688160
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.88782656
6motile cilium assembly (GO:0044458)5.12997369
7* axoneme assembly (GO:0035082)5.11098999
8ventricular system development (GO:0021591)5.05810923
9cellular potassium ion homeostasis (GO:0030007)4.79398121
10positive regulation of gamma-delta T cell activation (GO:0046645)4.69282735
11sodium ion export (GO:0071436)4.63276822
12mannose metabolic process (GO:0006013)4.50428911
13negative regulation of erythrocyte differentiation (GO:0045647)4.36224484
14sperm motility (GO:0030317)4.23587595
15negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.05110006
16regulation of gamma-delta T cell activation (GO:0046643)3.98363134
17response to pheromone (GO:0019236)3.96324860
18regulation of gamma-delta T cell differentiation (GO:0045586)3.95245220
19regulation of cilium movement (GO:0003352)3.93491573
20acrosome reaction (GO:0007340)3.85140830
21regulation of beta-amyloid formation (GO:1902003)3.74091455
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67822327
23left/right axis specification (GO:0070986)3.52511963
24positive regulation of cellular amide metabolic process (GO:0034250)3.51968682
25multicellular organism reproduction (GO:0032504)3.45910279
26tolerance induction (GO:0002507)3.43659395
27cerebellar granule cell differentiation (GO:0021707)3.40607025
28response to auditory stimulus (GO:0010996)3.40092285
29locomotory exploration behavior (GO:0035641)3.39577498
30cerebellar Purkinje cell differentiation (GO:0021702)3.36912316
31negative regulation of lymphocyte mediated immunity (GO:0002707)3.35480235
32regulation of inclusion body assembly (GO:0090083)3.34903218
33potassium ion import (GO:0010107)3.34367178
34germinal center formation (GO:0002467)3.33978412
35regulation of B cell receptor signaling pathway (GO:0050855)3.33792074
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.33117783
37cellular extravasation (GO:0045123)3.31580029
38antigen processing and presentation of endogenous antigen (GO:0019883)3.30968981
39microtubule severing (GO:0051013)3.26982651
40regulation of translation, ncRNA-mediated (GO:0045974)3.24980355
41negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.24980355
42negative regulation of translation, ncRNA-mediated (GO:0040033)3.24980355
43fusion of sperm to egg plasma membrane (GO:0007342)3.23034597
44activated T cell proliferation (GO:0050798)3.18996675
45negative regulation of inclusion body assembly (GO:0090084)3.18435106
46positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.16141721
47glial cell proliferation (GO:0014009)3.15339802
48positive regulation of protein kinase C signaling (GO:0090037)3.15314884
49negative regulation of cell killing (GO:0031342)3.15147183
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15147183
51B cell receptor signaling pathway (GO:0050853)3.14877263
52potassium ion homeostasis (GO:0055075)3.13914754
53positive regulation of histone deacetylation (GO:0031065)3.13827984
54regulation of ARF GTPase activity (GO:0032312)3.10834416
55response to muramyl dipeptide (GO:0032495)3.09788271
56* cilium organization (GO:0044782)3.09564922
57cellular sodium ion homeostasis (GO:0006883)3.08646210
58negative thymic T cell selection (GO:0045060)3.04804122
59ionotropic glutamate receptor signaling pathway (GO:0035235)3.02569861
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00742562
61acrosome assembly (GO:0001675)2.96753791
62negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96725598
63negative regulation of B cell mediated immunity (GO:0002713)2.95469395
64negative regulation of immunoglobulin mediated immune response (GO:0002890)2.95469395
65* cilium assembly (GO:0042384)2.94436195
66nonmotile primary cilium assembly (GO:0035058)2.91381799
67histone H3-K4 trimethylation (GO:0080182)2.91283807
68thymic T cell selection (GO:0045061)2.90441861
69positive regulation of granulocyte differentiation (GO:0030854)2.90365419
70modulation by virus of host process (GO:0019054)2.89128969
71negative T cell selection (GO:0043383)2.88412006
72positive thymic T cell selection (GO:0045059)2.87403120
73cell wall macromolecule metabolic process (GO:0044036)2.86147395
74cell wall macromolecule catabolic process (GO:0016998)2.86147395
75positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84031540
76detection of bacterium (GO:0016045)2.83834579
77membrane depolarization during action potential (GO:0086010)2.83758833
78sensory perception of smell (GO:0007608)2.81898195
79reproduction (GO:0000003)2.81359666
80regulation of short-term neuronal synaptic plasticity (GO:0048172)2.79484776
81retinal rod cell development (GO:0046548)2.78318178
82modulation by symbiont of host cellular process (GO:0044068)2.78040296
83negative regulation of leukocyte mediated immunity (GO:0002704)2.77398879
84detection of other organism (GO:0098543)2.77025063
85positive regulation of CREB transcription factor activity (GO:0032793)2.76493644
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76294133
87positive regulation by symbiont of host defense response (GO:0052509)2.75291981
88modulation by symbiont of host defense response (GO:0052031)2.75291981
89modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.75291981
90modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.75291981
91positive regulation by organism of defense response of other organism involved in symbiotic interact2.75291981
92modulation by symbiont of host immune response (GO:0052553)2.75291981
93response to interleukin-15 (GO:0070672)2.73648661
94T cell selection (GO:0045058)2.73376739
95negative regulation of T cell mediated immunity (GO:0002710)2.73267595
96L-amino acid import (GO:0043092)2.72317708
97positive regulation of protein deacetylation (GO:0090312)2.71977577
98regulation of cellular amide metabolic process (GO:0034248)2.71376408
99sperm-egg recognition (GO:0035036)2.71349298
100single fertilization (GO:0007338)2.71041651
101regulation of amyloid precursor protein catabolic process (GO:1902991)2.70397401
102histone H3-K9 modification (GO:0061647)2.69472044
103glutamate receptor signaling pathway (GO:0007215)2.69121414
104negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68957599
105cell-cell recognition (GO:0009988)2.68847265
106cilium morphogenesis (GO:0060271)2.68526214
107cell differentiation in hindbrain (GO:0021533)2.68128526
108spermatid development (GO:0007286)2.67966561
109negative regulation of granulocyte differentiation (GO:0030853)2.67950961
110regulation of granulocyte differentiation (GO:0030852)2.66335333
111cell communication by electrical coupling (GO:0010644)2.64400643
112negative regulation of interleukin-8 production (GO:0032717)2.64029316
113positive regulation of B cell differentiation (GO:0045579)2.64027601
114positive T cell selection (GO:0043368)2.63846746
115regulation of interferon-beta biosynthetic process (GO:0045357)2.62758902
116cellular response to exogenous dsRNA (GO:0071360)2.62750049
117negative regulation of adaptive immune response (GO:0002820)2.62443586
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62043057
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.60946405
120macrophage activation involved in immune response (GO:0002281)2.59233423
121regulation of tolerance induction (GO:0002643)2.56604164
122* microtubule bundle formation (GO:0001578)2.54834054
123negative regulation of oligodendrocyte differentiation (GO:0048715)2.54126299
124protein localization to cilium (GO:0061512)2.53853080
125long-term synaptic potentiation (GO:0060291)2.53797797
126exploration behavior (GO:0035640)2.52929492
127regulation of hydrogen peroxide metabolic process (GO:0010310)2.52479216
128regulation of microtubule-based movement (GO:0060632)2.52175290
129gamma-aminobutyric acid transport (GO:0015812)2.51438045
130detection of external biotic stimulus (GO:0098581)2.51243177
131regulation of response to osmotic stress (GO:0047484)2.48829084
132protein polyglutamylation (GO:0018095)2.48559693
133phosphatidylethanolamine biosynthetic process (GO:0006646)2.48174310
134mucosal-associated lymphoid tissue development (GO:0048537)2.48026930
135Peyers patch development (GO:0048541)2.48026930
136sperm capacitation (GO:0048240)2.47528695
137histone H4 deacetylation (GO:0070933)2.47408224
138regulation of germinal center formation (GO:0002634)2.47201386
139microglial cell activation (GO:0001774)2.46709247
140* cellular component assembly involved in morphogenesis (GO:0010927)2.46514246
141regulation of mast cell degranulation (GO:0043304)2.46242134
142histone H3-K36 demethylation (GO:0070544)2.46195403
143microtubule-based movement (GO:0007018)2.45928757
144negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.45718164
145negative regulation of T-helper cell differentiation (GO:0045623)2.45718164
146regulation of chemokine-mediated signaling pathway (GO:0070099)2.45474701
147plasma membrane fusion (GO:0045026)2.45022970
148G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43748016
149regulation of histone H3-K27 methylation (GO:0061085)2.43658654
150intraciliary transport (GO:0042073)2.43382061
151positive regulation of Rap GTPase activity (GO:0032854)2.41737872
152negative regulation of sodium ion transport (GO:0010766)2.41668518
153phosphatidylglycerol biosynthetic process (GO:0006655)2.41361449
154positive regulation of tolerance induction (GO:0002645)2.41196893
155response to peptidoglycan (GO:0032494)2.40749845
156regulation of B cell differentiation (GO:0045577)2.39866003
157histone H3-K9 demethylation (GO:0033169)2.39731461
158histone H3 deacetylation (GO:0070932)2.38857772
159nerve growth factor signaling pathway (GO:0038180)2.38578852
160activation of adenylate cyclase activity (GO:0007190)2.38409162
161glutamate secretion (GO:0014047)2.35509304
162long-term memory (GO:0007616)2.34541061
163regulation of mast cell activation involved in immune response (GO:0033006)2.34251257
164synaptic vesicle maturation (GO:0016188)2.34185958
165detection of molecule of bacterial origin (GO:0032490)2.33261151
166negative regulation of interleukin-6 production (GO:0032715)2.32932288
167cellular response to cholesterol (GO:0071397)2.31580494
168negative regulation of alpha-beta T cell activation (GO:0046636)2.31537217
169G-protein coupled receptor internalization (GO:0002031)2.31435293
170regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30908598
171neuroblast proliferation (GO:0007405)2.30887002
172response to type I interferon (GO:0034340)2.30484781
173regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.30295591
174regulation of ARF protein signal transduction (GO:0032012)2.30058750
175calcium ion-dependent exocytosis (GO:0017156)2.30037189
176protein localization to synapse (GO:0035418)2.29621323
177defense response to protozoan (GO:0042832)2.28653915
178regulation of myeloid leukocyte mediated immunity (GO:0002886)2.28227408
179histone H3-K9 methylation (GO:0051567)2.27864025
180negative regulation of innate immune response (GO:0045824)2.26749398
181negative regulation of type 2 immune response (GO:0002829)2.26048334
182interferon-gamma production (GO:0032609)2.25860001
183* cell projection assembly (GO:0030031)2.25716945
184amino acid import (GO:0043090)2.24614048
185synaptic transmission, glutamatergic (GO:0035249)2.24105564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88484744
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.41262725
3IKZF1_21737484_ChIP-ChIP_HCT116_Human2.92603371
4VDR_21846776_ChIP-Seq_THP-1_Human2.72979949
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.57580606
6* DROSHA_22980978_ChIP-Seq_HELA_Human2.45229001
7E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18764090
8* LXR_22292898_ChIP-Seq_THP-1_Human2.18048466
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12797046
10KDM2B_26808549_Chip-Seq_DND41_Human2.06942974
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.05893175
12SCL_19346495_ChIP-Seq_HPC-7_Human1.98056108
13KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.97790098
14VDR_24763502_ChIP-Seq_THP-1_Human1.96897056
15TCF7_22412390_ChIP-Seq_EML_Mouse1.96557576
16REST_21632747_ChIP-Seq_MESCs_Mouse1.96494907
17SPI1_23127762_ChIP-Seq_K562_Human1.89136655
18MAF_26560356_Chip-Seq_TH1_Human1.88197497
19MYC_22102868_ChIP-Seq_BL_Human1.85960478
20GATA1_19941826_ChIP-Seq_K562_Human1.80211982
21* P68_20966046_ChIP-Seq_HELA_Human1.78825218
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.78605438
23* MAF_26560356_Chip-Seq_TH2_Human1.76877627
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75053363
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74478655
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73403824
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.73096378
28UTX_26944678_Chip-Seq_JUKART_Human1.71387921
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71250909
30GBX2_23144817_ChIP-Seq_PC3_Human1.70688405
31SMC4_20622854_ChIP-Seq_HELA_Human1.67594929
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.65372442
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.64956446
34STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64480624
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.64454426
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.64300817
37BCL6_27268052_Chip-Seq_Bcells_Human1.64047435
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62967614
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62031973
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.61196965
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.60498140
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.59361784
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58824761
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56233560
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53965974
46BCOR_27268052_Chip-Seq_Bcells_Human1.53907310
47AR_21572438_ChIP-Seq_LNCaP_Human1.51851859
48KDM2B_26808549_Chip-Seq_JURKAT_Human1.50306961
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49211312
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49211312
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49107092
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49087133
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46495260
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46207797
55MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45980192
56EED_16625203_ChIP-ChIP_MESCs_Mouse1.45541672
57* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.45365029
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44417100
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.43423401
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40862833
61E2F1_20622854_ChIP-Seq_HELA_Human1.39871729
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.39419259
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.38638021
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.37502117
65RARB_27405468_Chip-Seq_BRAIN_Mouse1.34908497
66SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.34879759
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34644922
68NCOR1_26117541_ChIP-Seq_K562_Human1.33996581
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33620697
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33283583
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33283583
72* PHF8_20622854_ChIP-Seq_HELA_Human1.32806847
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.32362286
74CREB1_26743006_Chip-Seq_LNCaP_Human1.31949837
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30808977
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29471127
77CTCF_27219007_Chip-Seq_Bcells_Human1.28401692
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.27050773
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26052229
80SMAD4_21799915_ChIP-Seq_A2780_Human1.25889954
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.25235681
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24597428
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23456586
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22160286
85MYB_26560356_Chip-Seq_TH1_Human1.21852943
86OCT4_19829295_ChIP-Seq_ESCs_Human1.21795025
87TP63_22573176_ChIP-Seq_HFKS_Human1.21736546
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20757094
89GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19658372
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18728313
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18596010
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.16523477
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.16350100
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.15691919
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.15284157
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15276165
97MYB_26560356_Chip-Seq_TH2_Human1.15173959
98RUNX_20019798_ChIP-Seq_JUKART_Human1.14484720
99RARG_19884340_ChIP-ChIP_MEFs_Mouse1.14466489
100GATA2_19941826_ChIP-Seq_K562_Human1.14391304
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.14151621
102RACK7_27058665_Chip-Seq_MCF-7_Human1.13777027
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.13665161
104AHR_22903824_ChIP-Seq_MCF-7_Human1.13510193
105GATA1_26923725_Chip-Seq_HPCs_Mouse1.13043892
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11927455
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11155405
108P300_27268052_Chip-Seq_Bcells_Human1.10521086
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10121588
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09357883
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09333578
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09155910
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09095300
114GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08894906
115SMAD3_21741376_ChIP-Seq_ESCs_Human1.07819997
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07384839
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06919798
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.05923892
119GATA3_27048872_Chip-Seq_THYMUS_Human1.05280125
120KDM2B_26808549_Chip-Seq_K562_Human1.05039550
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04660033
122SA1_27219007_Chip-Seq_Bcells_Human1.04201974
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.04180035
124RNF2_27304074_Chip-Seq_NSC_Mouse1.03668113
125CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02921735
126EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.02539808
127RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01870628
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01860347
129AR_19668381_ChIP-Seq_PC3_Human1.01016395
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00952727
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99616800
132KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99609069
133TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99298587
134ERA_21632823_ChIP-Seq_H3396_Human0.99204914
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.98521977
136* STAT3_23295773_ChIP-Seq_U87_Human0.98476431
137AR_25329375_ChIP-Seq_VCAP_Human0.97419204
138RING1B_27294783_Chip-Seq_ESCs_Mouse0.97240906
139ESR2_21235772_ChIP-Seq_MCF-7_Human0.96784122
140P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.96748120
141CBX2_27304074_Chip-Seq_ESCs_Mouse0.96339491
142BP1_19119308_ChIP-ChIP_Hs578T_Human0.96229154
143P300_19829295_ChIP-Seq_ESCs_Human0.96086510
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95965268
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.95947237
146CBP_20019798_ChIP-Seq_JUKART_Human0.95947237
147TCF4_23295773_ChIP-Seq_U87_Human0.95843939
148CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95449031
149VDR_24787735_ChIP-Seq_THP-1_Human0.95313364
150RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94525954
151NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93405097
152STAT1_20625510_ChIP-Seq_HELA_Human0.93311035
153ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93128300
154STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92763065
155SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92168668
156TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92128292
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91815669
158CTCF_20526341_ChIP-Seq_ESCs_Human0.91611662
159LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91158337
160KLF4_19829295_ChIP-Seq_ESCs_Human0.91156249
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.91143631
162TBL1_22424771_ChIP-Seq_293T_Human0.91050787
163STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90986796
164WDR5_24793694_ChIP-Seq_LNCAP_Human0.90637108
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.89546153
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88377471
167NANOG_18555785_Chip-Seq_ESCs_Mouse0.87710026
168PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87665721
169IRF8_27001747_Chip-Seq_BMDM_Mouse0.86871054
170TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86541075
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85479215
172NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.84443540
173CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83461415
174ZNF274_21170338_ChIP-Seq_K562_Hela0.83076402
175EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83066013
176RING1B_27294783_Chip-Seq_NPCs_Mouse0.83050261
177RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81940706
178ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81445901
179SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81181496
180CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79591917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.34257211
2MP0001984_abnormal_olfaction4.19507868
3MP0005410_abnormal_fertilization4.05477478
4MP0003436_decreased_susceptibility_to3.44002461
5MP0004859_abnormal_synaptic_plasticity3.13581782
6MP0004858_abnormal_nervous_system2.85137940
7MP0009046_muscle_twitch2.73772049
8MP0002653_abnormal_ependyma_morphology2.71355794
9MP0003303_peritoneal_inflammation2.67838067
10MP0003724_increased_susceptibility_to2.54491103
11MP0001835_abnormal_antigen_presentation2.49498570
12MP0005646_abnormal_pituitary_gland2.42038134
13MP0002638_abnormal_pupillary_reflex2.41019382
14MP0001986_abnormal_taste_sensitivity2.34619101
15MP0005645_abnormal_hypothalamus_physiol2.29847825
16MP0004885_abnormal_endolymph2.28801703
17MP0005423_abnormal_somatic_nervous2.23313259
18MP0003329_amyloid_beta_deposits2.21366318
19MP0003878_abnormal_ear_physiology2.20804811
20MP0005377_hearing/vestibular/ear_phenot2.20804811
21MP0005025_abnormal_response_to2.14148464
22MP0002419_abnormal_innate_immunity2.10058686
23MP0001502_abnormal_circadian_rhythm2.10021601
24MP0003635_abnormal_synaptic_transmissio2.07844742
25MP0002132_abnormal_respiratory_system2.06627107
26MP0002723_abnormal_immune_serum2.05001404
27MP0004043_abnormal_pH_regulation1.95772313
28MP0001486_abnormal_startle_reflex1.94848124
29MP0002420_abnormal_adaptive_immunity1.91260680
30MP0002933_joint_inflammation1.90527280
31MP0005000_abnormal_immune_tolerance1.90141711
32MP0001819_abnormal_immune_cell1.88736773
33MP0002452_abnormal_antigen_presenting1.88129187
34MP0004130_abnormal_muscle_cell1.86464918
35MP0001440_abnormal_grooming_behavior1.86372086
36MP0004742_abnormal_vestibular_system1.83223849
37MP0002405_respiratory_system_inflammati1.82539775
38MP0000778_abnormal_nervous_system1.77724324
39MP0008569_lethality_at_weaning1.77593374
40MP0005551_abnormal_eye_electrophysiolog1.76372370
41MP0002064_seizures1.74829867
42MP0003698_abnormal_male_reproductive1.72653985
43MP0003183_abnormal_peptide_metabolism1.68070292
44MP0005499_abnormal_olfactory_system1.67318099
45MP0005394_taste/olfaction_phenotype1.67318099
46MP0009745_abnormal_behavioral_response1.61600163
47MP0002572_abnormal_emotion/affect_behav1.61551681
48MP0003690_abnormal_glial_cell1.60934397
49MP0002396_abnormal_hematopoietic_system1.60871910
50MP0002063_abnormal_learning/memory/cond1.59499541
51MP0001501_abnormal_sleep_pattern1.58710565
52MP0001958_emphysema1.57765146
53MP0002272_abnormal_nervous_system1.55245300
54MP0005397_hematopoietic_system_phenotyp1.55074544
55MP0001545_abnormal_hematopoietic_system1.55074544
56MP0003136_yellow_coat_color1.54608738
57MP0002398_abnormal_bone_marrow1.52058482
58MP0000604_amyloidosis1.51398584
59MP0000716_abnormal_immune_system1.50577048
60MP0001533_abnormal_skeleton_physiology1.49758711
61MP0002557_abnormal_social/conspecific_i1.48639645
62MP0005174_abnormal_tail_pigmentation1.47814016
63MP0005503_abnormal_tendon_morphology1.43991115
64MP0002067_abnormal_sensory_capabilities1.42955855
65MP0005083_abnormal_biliary_tract1.42247679
66MP0002736_abnormal_nociception_after1.40479281
67MP0004947_skin_inflammation1.36814654
68MP0003172_abnormal_lysosome_physiology1.36134156
69MP0002735_abnormal_chemical_nociception1.35498982
70MP0003880_abnormal_central_pattern1.35298571
71MP0003634_abnormal_glial_cell1.34912476
72MP0005409_darkened_coat_color1.32418107
73MP0010155_abnormal_intestine_physiology1.32338380
74MP0001485_abnormal_pinna_reflex1.32164753
75MP0009785_altered_susceptibility_to1.31368887
76MP0000015_abnormal_ear_pigmentation1.30817863
77MP0001968_abnormal_touch/_nociception1.28888164
78MP0004510_myositis1.28861525
79MP0008995_early_reproductive_senescence1.26927169
80MP0001348_abnormal_lacrimal_gland1.25912261
81MP0003866_abnormal_defecation1.25899141
82MP0002254_reproductive_system_inflammat1.25715186
83MP0005253_abnormal_eye_physiology1.24552356
84MP0000678_abnormal_parathyroid_gland1.22975111
85MP0008789_abnormal_olfactory_epithelium1.22700677
86MP0006072_abnormal_retinal_apoptosis1.20493218
87MP0002882_abnormal_neuron_morphology1.20260074
88MP0002249_abnormal_larynx_morphology1.20194864
89MP0006082_CNS_inflammation1.16694552
90MP0000703_abnormal_thymus_morphology1.16457382
91MP0005623_abnormal_meninges_morphology1.16361824
92MP0005076_abnormal_cell_differentiation1.16081240
93MP0003045_fibrosis1.15500025
94MP0002429_abnormal_blood_cell1.15416799
95MP0002184_abnormal_innervation1.14888255
96MP0002734_abnormal_mechanical_nocicepti1.14437345
97MP0000689_abnormal_spleen_morphology1.13304824
98MP0002722_abnormal_immune_system1.12081621
99MP0004270_analgesia1.11974982
100MP0004883_abnormal_blood_vessel1.11575530
101MP0003279_aneurysm1.10124026
102MP0002152_abnormal_brain_morphology1.09818486
103MP0001845_abnormal_inflammatory_respons1.08224730
104MP0004811_abnormal_neuron_physiology1.07624986
105MP0001929_abnormal_gametogenesis1.05837877
106MP0002138_abnormal_hepatobiliary_system1.05648237
107MP0000955_abnormal_spinal_cord1.05620167
108MP0003632_abnormal_nervous_system1.05339040
109MP0002909_abnormal_adrenal_gland1.04594926
110MP0000013_abnormal_adipose_tissue1.03564004
111MP0009333_abnormal_splenocyte_physiolog1.03115412
112MP0003656_abnormal_erythrocyte_physiolo1.02259826
113MP0002148_abnormal_hypersensitivity_rea1.01986705
114MP0005167_abnormal_blood-brain_barrier1.01566447
115MP0001663_abnormal_digestive_system1.01095351
116MP0000003_abnormal_adipose_tissue1.00916409
117MP0009115_abnormal_fat_cell1.00430713
118MP0000685_abnormal_immune_system0.99913137
119MP0005464_abnormal_platelet_physiology0.98767261
120MP0002229_neurodegeneration0.98267946
121MP0003633_abnormal_nervous_system0.96630323
122MP0009384_cardiac_valve_regurgitation0.96623341
123MP0001270_distended_abdomen0.96493652
124MP0002998_abnormal_bone_remodeling0.95709348
125MP0003763_abnormal_thymus_physiology0.95588860
126MP0005375_adipose_tissue_phenotype0.95355331
127MP0008469_abnormal_protein_level0.93445416
128MP0003631_nervous_system_phenotype0.92865890
129MP0001963_abnormal_hearing_physiology0.91823283
130MP0005671_abnormal_response_to0.91419739
131MP0001970_abnormal_pain_threshold0.91325001
132MP0002090_abnormal_vision0.91223742
133MP0003879_abnormal_hair_cell0.90732081
134MP0008875_abnormal_xenobiotic_pharmacok0.87738496
135MP0001765_abnormal_ion_homeostasis0.87201350
136MP0005535_abnormal_body_temperature0.86747111
137MP0001299_abnormal_eye_distance/0.86134541
138MP0001853_heart_inflammation0.85152343
139MP0002752_abnormal_somatic_nervous0.83254688
140MP0005670_abnormal_white_adipose0.83016602
141MP0000249_abnormal_blood_vessel0.82860862
142MP0001790_abnormal_immune_system0.82654968
143MP0005387_immune_system_phenotype0.82654968
144MP0001851_eye_inflammation0.82521715
145MP0005666_abnormal_adipose_tissue0.81980171
146MP0003300_gastrointestinal_ulcer0.81594832
147MP0002066_abnormal_motor_capabilities/c0.81535463
148MP0002161_abnormal_fertility/fecundity0.81208184
149MP0000920_abnormal_myelination0.80918325
150MP0005195_abnormal_posterior_eye0.80300311
151MP0002928_abnormal_bile_duct0.79895437
152MP0002136_abnormal_kidney_physiology0.79451324
153MP0009764_decreased_sensitivity_to0.79161694
154MP0001873_stomach_inflammation0.77912138
155MP0004808_abnormal_hematopoietic_stem0.77795068
156MP0005391_vision/eye_phenotype0.76863177
157MP0005390_skeleton_phenotype0.76377751
158MP0008961_abnormal_basal_metabolism0.75938864
159MP0002277_abnormal_respiratory_mucosa0.74554327
160MP0005164_abnormal_response_to0.74416100
161MP0003828_pulmonary_edema0.72911507
162MP0000026_abnormal_inner_ear0.72405206
163MP0003075_altered_response_to0.72368237
164MP0001324_abnormal_eye_pigmentation0.72155088
165MP0002733_abnormal_thermal_nociception0.72074108
166MP0001346_abnormal_lacrimal_gland0.71593640
167MP0005310_abnormal_salivary_gland0.71307586
168MP0009278_abnormal_bone_marrow0.70956094
169MP0005058_abnormal_lysosome_morphology0.70033830
170MP0002971_abnormal_brown_adipose0.69448943
171MP0001800_abnormal_humoral_immune0.69077194
172MP0004381_abnormal_hair_follicle0.68683212
173MP0005448_abnormal_energy_balance0.68065770
174MP0010329_abnormal_lipoprotein_level0.66571696

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.99893736
2Abnormal respiratory motile cilium physiology (HP:0012261)7.94347107
3Abnormal ciliary motility (HP:0012262)7.01918032
4Absent/shortened dynein arms (HP:0200106)6.73357182
5Dynein arm defect of respiratory motile cilia (HP:0012255)6.73357182
6Rhinitis (HP:0012384)6.62376642
7Abnormal respiratory epithelium morphology (HP:0012253)5.97161290
8Abnormal respiratory motile cilium morphology (HP:0005938)5.97161290
9Chronic bronchitis (HP:0004469)5.09150517
10Nasal polyposis (HP:0100582)3.94574227
11Bronchiectasis (HP:0002110)3.87177696
12Myositis (HP:0100614)3.52043033
13Obstructive sleep apnea (HP:0002870)3.29389967
14Abnormal delayed hypersensitivity skin test (HP:0002963)3.18417603
15Eczematoid dermatitis (HP:0000976)3.07971014
16Abnormality of midbrain morphology (HP:0002418)3.05580780
17Molar tooth sign on MRI (HP:0002419)3.05580780
18Abnormality of the nasal mucosa (HP:0000433)2.96440996
19Colitis (HP:0002583)2.92354657
20Recurrent sinusitis (HP:0011108)2.91464056
21Bronchitis (HP:0012387)2.90623144
22Nephronophthisis (HP:0000090)2.82102356
23Gastrointestinal infarctions (HP:0005244)2.81362498
24Orchitis (HP:0100796)2.81304797
25Supranuclear gaze palsy (HP:0000605)2.80579846
26Hemiplegia (HP:0002301)2.78527411
27Retrobulbar optic neuritis (HP:0100654)2.76615913
28Optic neuritis (HP:0100653)2.76615913
29Recurrent otitis media (HP:0000403)2.69944196
30Megalencephaly (HP:0001355)2.67817759
31Elevated erythrocyte sedimentation rate (HP:0003565)2.67221023
32Atelectasis (HP:0100750)2.66648052
33Abnormality of binocular vision (HP:0011514)2.63717262
34Diplopia (HP:0000651)2.63717262
35Recurrent cutaneous fungal infections (HP:0011370)2.63337827
36Chronic mucocutaneous candidiasis (HP:0002728)2.63337827
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61720464
38Panhypogammaglobulinemia (HP:0003139)2.60720489
39Increased IgE level (HP:0003212)2.60245508
40Medial flaring of the eyebrow (HP:0010747)2.59671942
41Pancreatic fibrosis (HP:0100732)2.56798300
42Prolonged bleeding time (HP:0003010)2.53446235
43Neurofibrillary tangles (HP:0002185)2.44082648
44Hemiparesis (HP:0001269)2.43427025
45Progressive cerebellar ataxia (HP:0002073)2.42875307
46Chronic sinusitis (HP:0011109)2.39810051
47Meningitis (HP:0001287)2.38020983
48Abnormality of the renal medulla (HP:0100957)2.36598940
49Chronic obstructive pulmonary disease (HP:0006510)2.33010698
50Obstructive lung disease (HP:0006536)2.33010698
51True hermaphroditism (HP:0010459)2.30197108
52Gait imbalance (HP:0002141)2.28130079
53Papilledema (HP:0001085)2.27573995
54Inflammation of the large intestine (HP:0002037)2.27419318
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.26695604
56Recurrent gram-negative bacterial infections (HP:0005420)2.25687054
57Congenital primary aphakia (HP:0007707)2.25574549
58Thin bony cortex (HP:0002753)2.24807021
59Hemoptysis (HP:0002105)2.24195107
60Infertility (HP:0000789)2.22764883
61Gastrointestinal inflammation (HP:0004386)2.21212192
62Cystic liver disease (HP:0006706)2.21195945
63Chronic otitis media (HP:0000389)2.16006885
64Hemorrhage of the eye (HP:0011885)2.15351244
65Polyphagia (HP:0002591)2.12966129
66Pustule (HP:0200039)2.12569590
67Nephrogenic diabetes insipidus (HP:0009806)2.12517646
68Spontaneous hematomas (HP:0007420)2.11999513
69Hypochromic anemia (HP:0001931)2.11661041
70Abnormality of polysaccharide metabolism (HP:0011012)2.09542264
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09542264
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09542264
73Agammaglobulinemia (HP:0004432)2.08107257
74Recurrent skin infections (HP:0001581)2.06559526
75Mediastinal lymphadenopathy (HP:0100721)2.05382832
76Genetic anticipation (HP:0003743)2.03511509
77Hypoplastic ischia (HP:0003175)2.02588416
78Mucopolysacchariduria (HP:0008155)2.01035655
79Urinary glycosaminoglycan excretion (HP:0003541)2.01035655
80Emphysema (HP:0002097)2.00669628
81Vasculitis (HP:0002633)2.00240164
82Chronic hepatic failure (HP:0100626)1.98600488
83Congenital hepatic fibrosis (HP:0002612)1.97560580
84Dysostosis multiplex (HP:0000943)1.95688987
85Postaxial foot polydactyly (HP:0001830)1.94714628
86Febrile seizures (HP:0002373)1.94557144
87Epileptic encephalopathy (HP:0200134)1.94281159
88Median cleft lip (HP:0000161)1.94025224
89Polydipsia (HP:0001959)1.93873481
90Abnormal drinking behavior (HP:0030082)1.93873481
91Bell-shaped thorax (HP:0001591)1.93594688
92Pulmonary infiltrates (HP:0002113)1.93123993
93Abnormality of macrophages (HP:0004311)1.91043330
94Abnormality of liposaccharide metabolism (HP:0010968)1.89677669
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.89677669
96Abnormality of glycolipid metabolism (HP:0010969)1.89677669
97Encephalitis (HP:0002383)1.89065640
98Keratoconjunctivitis sicca (HP:0001097)1.88420274
99Cervical subluxation (HP:0003308)1.86996768
100Abnormality of saccadic eye movements (HP:0000570)1.86894288
101Tubular atrophy (HP:0000092)1.85500146
102Postaxial hand polydactyly (HP:0001162)1.85465915
103Clumsiness (HP:0002312)1.84896957
104Joint stiffness (HP:0001387)1.84416630
105Decreased circulating renin level (HP:0003351)1.83767839
106Slow saccadic eye movements (HP:0000514)1.83526980
107Gingivitis (HP:0000230)1.82855662
108Keratoconjunctivitis (HP:0001096)1.79048103
109Pancreatic cysts (HP:0001737)1.78985055
110Pulmonary embolism (HP:0002204)1.78656000
111Split foot (HP:0001839)1.78107685
112Broad face (HP:0000283)1.77237036
113Neoplasm of the heart (HP:0100544)1.77158814
114Aplasia/Hypoplasia of the lens (HP:0008063)1.76660286
115Metaphyseal cupping (HP:0003021)1.76247530
116Postural instability (HP:0002172)1.76155848
117Peritonitis (HP:0002586)1.75900301
118Increased neuronal autofluorescent lipopigment (HP:0002074)1.74822473
119Focal seizures (HP:0007359)1.74698693
120Tubulointerstitial nephritis (HP:0001970)1.74488643
121Cerebral inclusion bodies (HP:0100314)1.73709251
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73489809
123Bile duct proliferation (HP:0001408)1.73442163
124Abnormal biliary tract physiology (HP:0012439)1.73442163
125Granulocytopenia (HP:0001913)1.72528936
126Abnormal eating behavior (HP:0100738)1.72403654
127Broad distal phalanx of finger (HP:0009836)1.71837770
128Annular pancreas (HP:0001734)1.71789426
129Segmental peripheral demyelination/remyelination (HP:0003481)1.71196732
130Abnormality of the peritoneum (HP:0002585)1.70474658
131Epistaxis (HP:0000421)1.70138064
132Central scotoma (HP:0000603)1.69097770
133Hip dysplasia (HP:0001385)1.67060820
134Cellulitis (HP:0100658)1.66866651
135Recurrent abscess formation (HP:0002722)1.66502349
136Acne (HP:0001061)1.66442686
137Hypertensive crisis (HP:0100735)1.65025832
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.64012250
139Abnormality of ocular smooth pursuit (HP:0000617)1.62782233
140Increased cerebral lipofuscin (HP:0011813)1.62665618
141Chest pain (HP:0100749)1.62275730
142Action tremor (HP:0002345)1.61690221
143Occipital encephalocele (HP:0002085)1.58410913
144Dysdiadochokinesis (HP:0002075)1.57923416
145Focal motor seizures (HP:0011153)1.56421769
146Abnormality of macular pigmentation (HP:0008002)1.56226676
147Genital tract atresia (HP:0001827)1.56120480
148Poor coordination (HP:0002370)1.55627067
149Polyuria (HP:0000103)1.52127502
150Recurrent fungal infections (HP:0002841)1.52117916
151Abnormal urine output (HP:0012590)1.51488659
152Vaginal atresia (HP:0000148)1.51356081
153Impaired smooth pursuit (HP:0007772)1.51290013
154Bony spicule pigmentary retinopathy (HP:0007737)1.51068992
155Recurrent bacterial skin infections (HP:0005406)1.50719446
156J-shaped sella turcica (HP:0002680)1.50066697
157Anencephaly (HP:0002323)1.49149631
158Abnormality of the renal cortex (HP:0011035)1.47161779
159Gaze-evoked nystagmus (HP:0000640)1.46571489
160Recurrent bronchitis (HP:0002837)1.44938228
161Abnormality of the dental root (HP:0006486)1.44315423
162Taurodontia (HP:0000679)1.44315423
163Abnormality of permanent molar morphology (HP:0011071)1.44315423
164Oculomotor apraxia (HP:0000657)1.43892378
165Truncal ataxia (HP:0002078)1.42891734
166Nephropathy (HP:0000112)1.42380584
167Heterotopia (HP:0002282)1.40526103
168Hypotelorism (HP:0000601)1.39098066
169Abnormality of the fingertips (HP:0001211)1.38893439
170Abnormality of the dental pulp (HP:0006479)1.38076424
171Oligodactyly (hands) (HP:0001180)1.38051130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK3.56564449
2ICK3.44004338
3NTRK23.42413166
4TRIB33.11535800
5MAPK152.90918565
6TNIK2.75005065
7PRKD32.56667135
8ERN12.53324842
9MAP3K132.51060126
10SIK22.42737429
11BLK2.29080785
12CAMK1G2.17239975
13IRAK41.99899308
14MAP3K141.98846933
15IRAK21.98303880
16RIPK41.96094649
17SIK11.82775986
18IRAK11.72171814
19MAP2K31.67686371
20TAOK31.65234202
21SGK21.61225674
22JAK31.53309682
23EPHB11.52992717
24MAP2K61.46080095
25PHKG11.45065834
26PHKG21.45065834
27SIK31.42674803
28EEF2K1.40025501
29TXK1.36635397
30NTRK31.34617903
31PRPF4B1.32693692
32STK381.32277220
33FRK1.30553268
34SGK31.29541913
35PAK61.26078549
36HCK1.20117836
37SGK2231.18818450
38SGK4941.18818450
39CAMK1D1.17904998
40CAMKK21.15016659
41WNK41.14550436
42IKBKE1.10473685
43JAK11.09476687
44MAP3K61.08802316
45MAP4K11.07540112
46LMTK21.04626353
47RIPK11.02470078
48TYK21.00414225
49WNK11.00295380
50MAPK120.99564733
51FGFR30.92621885
52FES0.90363255
53PRKCH0.87702616
54PDPK10.87331825
55PRKCG0.86392032
56PDK10.86329713
57CAMKK10.85201624
58LCK0.83854995
59MAPK70.83013052
60MARK20.82426291
61TNK20.81318882
62LYN0.81222919
63MARK30.80970642
64PKN20.79425693
65MAP3K90.79059197
66INSRR0.76670051
67FGR0.75592013
68KIT0.73499595
69CSF1R0.73459436
70HIPK20.73312118
71PRKCQ0.72858317
72PTK60.72857605
73RET0.72848856
74PRKD20.71616376
75RPS6KA20.71525285
76TBK10.70712086
77TEC0.70483106
78RPS6KA60.70367891
79IKBKB0.69482358
80MAP3K110.68831206
81EPHA40.67981724
82ERBB30.67764123
83BRD40.67556006
84MAP3K20.67501313
85ZAP700.66383122
86DDR20.65719102
87GRK10.65527182
88MAP3K40.65044254
89ITK0.64817724
90GRK60.64679486
91NLK0.63031292
92AKT30.62852134
93KSR20.62683829
94SGK10.62436201
95MARK10.61677390
96RPS6KC10.61500263
97RPS6KL10.61500263
98MTOR0.61269271
99CDK120.61233625
100MINK10.60915708
101MAPK110.60773649
102CDK50.60487575
103ERBB20.59663856
104TRPM70.59516167
105CDC42BPA0.58877599
106MAPKAPK30.58521309
107MAPK100.57191165
108CAMK40.57164501
109CSK0.56887656
110PDGFRB0.55914805
111MAP3K10.55692563
112DAPK20.55636179
113DYRK1A0.55045765
114FGFR20.54252787
115STK110.54186741
116PTK2B0.53440977
117BMX0.52272456
118FYN0.50584029
119CAMK10.50371053
120MATK0.49680237
121MAPK80.48226365
122MAPK30.48145368
123MAP3K100.47613981
124DYRK1B0.47188562
125FGFR40.47183056
126JAK20.46831263
127EPHA30.45524681
128MAPK130.44238389
129TYRO30.44202004
130ALK0.42300931
131PRKCZ0.42214854
132CHUK0.41575338
133PRKG10.41569923
134SYK0.40374089
135ROCK20.39467569
136SRC0.38399958
137PRKAA20.37607067
138MAP3K70.37412721
139BMPR20.34846778
140BTK0.34568636

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.88225641
2Nicotine addiction_Homo sapiens_hsa050332.33715796
3Glutamatergic synapse_Homo sapiens_hsa047242.06807845
4Circadian entrainment_Homo sapiens_hsa047131.89132851
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.88926260
6Staphylococcus aureus infection_Homo sapiens_hsa051501.85825408
7Insulin secretion_Homo sapiens_hsa049111.82759577
8Fatty acid biosynthesis_Homo sapiens_hsa000611.81245081
9Morphine addiction_Homo sapiens_hsa050321.78361573
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.77589719
11Gastric acid secretion_Homo sapiens_hsa049711.73006474
12Dorso-ventral axis formation_Homo sapiens_hsa043201.71108736
13Salivary secretion_Homo sapiens_hsa049701.69880804
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68667413
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.67033489
16Graft-versus-host disease_Homo sapiens_hsa053321.66556735
17Acute myeloid leukemia_Homo sapiens_hsa052211.62696971
18GABAergic synapse_Homo sapiens_hsa047271.61643929
19Phototransduction_Homo sapiens_hsa047441.54855724
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49841736
21Long-term potentiation_Homo sapiens_hsa047201.49787790
22Autoimmune thyroid disease_Homo sapiens_hsa053201.45848446
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45058854
24Synaptic vesicle cycle_Homo sapiens_hsa047211.44159719
25Taste transduction_Homo sapiens_hsa047421.36651649
26VEGF signaling pathway_Homo sapiens_hsa043701.35311971
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30800477
28cAMP signaling pathway_Homo sapiens_hsa040241.25019226
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22848927
30Amphetamine addiction_Homo sapiens_hsa050311.21004457
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18894863
32Calcium signaling pathway_Homo sapiens_hsa040201.17939562
33Cholinergic synapse_Homo sapiens_hsa047251.17265936
34Type II diabetes mellitus_Homo sapiens_hsa049301.16193777
35Osteoclast differentiation_Homo sapiens_hsa043801.13668216
36Primary immunodeficiency_Homo sapiens_hsa053401.11743872
37Dopaminergic synapse_Homo sapiens_hsa047281.11355162
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09842579
39TNF signaling pathway_Homo sapiens_hsa046681.09804036
40Renin secretion_Homo sapiens_hsa049241.09774691
41Thyroid hormone synthesis_Homo sapiens_hsa049181.06601695
42Type I diabetes mellitus_Homo sapiens_hsa049401.05604560
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05468764
44mTOR signaling pathway_Homo sapiens_hsa041501.05021084
45B cell receptor signaling pathway_Homo sapiens_hsa046621.03619669
46Hematopoietic cell lineage_Homo sapiens_hsa046401.03549074
47Estrogen signaling pathway_Homo sapiens_hsa049151.02850362
48Influenza A_Homo sapiens_hsa051641.01873167
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01487657
50Platelet activation_Homo sapiens_hsa046110.98843700
51Cocaine addiction_Homo sapiens_hsa050300.98493389
52Prolactin signaling pathway_Homo sapiens_hsa049170.96923287
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96713925
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93681040
55Serotonergic synapse_Homo sapiens_hsa047260.93672276
56Circadian rhythm_Homo sapiens_hsa047100.93632337
57Non-small cell lung cancer_Homo sapiens_hsa052230.93423104
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.92877723
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92249387
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.91743415
61Hepatitis C_Homo sapiens_hsa051600.91554739
62Mineral absorption_Homo sapiens_hsa049780.89783965
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89458172
64T cell receptor signaling pathway_Homo sapiens_hsa046600.88667848
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88601205
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88302301
67Chemokine signaling pathway_Homo sapiens_hsa040620.87753616
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87288278
69Chronic myeloid leukemia_Homo sapiens_hsa052200.86704847
70Pancreatic secretion_Homo sapiens_hsa049720.85267425
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84002097
72GnRH signaling pathway_Homo sapiens_hsa049120.83549532
73Long-term depression_Homo sapiens_hsa047300.81781877
74Linoleic acid metabolism_Homo sapiens_hsa005910.81540308
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.81078078
76Notch signaling pathway_Homo sapiens_hsa043300.80384772
77African trypanosomiasis_Homo sapiens_hsa051430.78886921
78Oxytocin signaling pathway_Homo sapiens_hsa049210.77543645
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76688833
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75999227
81Choline metabolism in cancer_Homo sapiens_hsa052310.74728740
82Herpes simplex infection_Homo sapiens_hsa051680.74503170
83Axon guidance_Homo sapiens_hsa043600.71711120
84Inositol phosphate metabolism_Homo sapiens_hsa005620.71631623
85FoxO signaling pathway_Homo sapiens_hsa040680.71095217
86Glucagon signaling pathway_Homo sapiens_hsa049220.70324502
87Sphingolipid metabolism_Homo sapiens_hsa006000.70238606
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.70212256
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70151934
90Malaria_Homo sapiens_hsa051440.70112731
91MAPK signaling pathway_Homo sapiens_hsa040100.69279524
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.68666673
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.68518051
94Hepatitis B_Homo sapiens_hsa051610.68091635
95Bile secretion_Homo sapiens_hsa049760.66395644
96Antigen processing and presentation_Homo sapiens_hsa046120.65859432
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64385966
98Lysine degradation_Homo sapiens_hsa003100.63883911
99Melanogenesis_Homo sapiens_hsa049160.63352273
100Pertussis_Homo sapiens_hsa051330.62844112
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62827085
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62434571
103Glycosaminoglycan degradation_Homo sapiens_hsa005310.61764715
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61566150
105Pancreatic cancer_Homo sapiens_hsa052120.61010220
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.60954435
107Ovarian steroidogenesis_Homo sapiens_hsa049130.60810548
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60755214
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.60682364
110Renal cell carcinoma_Homo sapiens_hsa052110.60619219
111Collecting duct acid secretion_Homo sapiens_hsa049660.59386646
112Gap junction_Homo sapiens_hsa045400.59106990
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58500857
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58458961
115Allograft rejection_Homo sapiens_hsa053300.58063443
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57895752
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57666532
118Glycerolipid metabolism_Homo sapiens_hsa005610.57071031
119Histidine metabolism_Homo sapiens_hsa003400.55268876
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55113914
121Asthma_Homo sapiens_hsa053100.54964922
122Other glycan degradation_Homo sapiens_hsa005110.53648100
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53515056
124Toxoplasmosis_Homo sapiens_hsa051450.53303034
125Viral myocarditis_Homo sapiens_hsa054160.52777639
126Tuberculosis_Homo sapiens_hsa051520.52680214
127ABC transporters_Homo sapiens_hsa020100.52460058
128Adipocytokine signaling pathway_Homo sapiens_hsa049200.52410909
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51974896
130Ras signaling pathway_Homo sapiens_hsa040140.51526063
131Insulin resistance_Homo sapiens_hsa049310.50336121
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.50004515
133Measles_Homo sapiens_hsa051620.49989011
134Complement and coagulation cascades_Homo sapiens_hsa046100.48886383
135Leishmaniasis_Homo sapiens_hsa051400.47790472
136ErbB signaling pathway_Homo sapiens_hsa040120.47332179
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47010278
138Ether lipid metabolism_Homo sapiens_hsa005650.46780443
139Lysosome_Homo sapiens_hsa041420.46363771
140Vascular smooth muscle contraction_Homo sapiens_hsa042700.46312894
141Glioma_Homo sapiens_hsa052140.45790946

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