TTLL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.28039630
2piRNA metabolic process (GO:0034587)8.08232026
3* sperm motility (GO:0030317)7.93416831
4acrosome reaction (GO:0007340)7.69985665
5axonemal dynein complex assembly (GO:0070286)7.37885881
6multicellular organism reproduction (GO:0032504)7.18538057
7acrosome assembly (GO:0001675)7.02244889
8epithelial cilium movement (GO:0003351)6.81552927
9male meiosis (GO:0007140)6.65871784
10sperm-egg recognition (GO:0035036)6.62857384
11motile cilium assembly (GO:0044458)6.39832313
12plasma membrane fusion (GO:0045026)6.34819290
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.19740314
14cilium movement (GO:0003341)6.14326715
15cell-cell recognition (GO:0009988)6.03102580
16spermatid development (GO:0007286)5.99561226
17synaptonemal complex organization (GO:0070193)5.98015009
18binding of sperm to zona pellucida (GO:0007339)5.85386272
19reproduction (GO:0000003)5.75495577
20synaptonemal complex assembly (GO:0007130)5.75093102
21DNA methylation involved in gamete generation (GO:0043046)5.54189346
22negative regulation of inclusion body assembly (GO:0090084)5.53932410
23regulation of cilium movement (GO:0003352)5.52271288
24cell wall macromolecule metabolic process (GO:0044036)5.30675085
25cell wall macromolecule catabolic process (GO:0016998)5.30675085
26sperm capacitation (GO:0048240)4.99896685
27single fertilization (GO:0007338)4.92734684
28male meiosis I (GO:0007141)4.88392742
29ventricular system development (GO:0021591)4.48103564
30calcium ion-dependent exocytosis (GO:0017156)4.36842664
31central nervous system myelination (GO:0022010)4.33508683
32axon ensheathment in central nervous system (GO:0032291)4.33508683
33* fertilization (GO:0009566)4.30987374
34spermatogenesis (GO:0007283)4.25833396
35male gamete generation (GO:0048232)4.24252481
36microtubule severing (GO:0051013)4.16784952
37chromosome organization involved in meiosis (GO:0070192)4.12465837
38microtubule depolymerization (GO:0007019)4.09026682
39gamete generation (GO:0007276)3.98480306
40meiosis I (GO:0007127)3.86570337
41germ cell development (GO:0007281)3.82533231
42protein localization to cilium (GO:0061512)3.82230125
43regulation of DNA endoreduplication (GO:0032875)3.80951233
44meiotic nuclear division (GO:0007126)3.78969386
45* cellular process involved in reproduction in multicellular organism (GO:0022412)3.71150154
46regulation of inclusion body assembly (GO:0090083)3.70995397
47replication fork processing (GO:0031297)3.60794293
48retinal cone cell development (GO:0046549)3.53895023
49meiotic cell cycle (GO:0051321)3.53066656
50recombinational repair (GO:0000725)3.49574019
51double-strand break repair via homologous recombination (GO:0000724)3.49459091
52regulation of meiosis I (GO:0060631)3.42058671
53rRNA catabolic process (GO:0016075)3.41988679
54resolution of meiotic recombination intermediates (GO:0000712)3.38821719
55cell recognition (GO:0008037)3.38513019
56DNA deamination (GO:0045006)3.35787764
57protein K11-linked deubiquitination (GO:0035871)3.33479123
58regulation of microtubule-based movement (GO:0060632)3.33436439
59intraciliary transport (GO:0042073)3.29245867
60rRNA methylation (GO:0031167)3.26898691
61histone exchange (GO:0043486)3.24969367
62rRNA modification (GO:0000154)3.24058573
63cell proliferation in forebrain (GO:0021846)3.21739505
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.19347973
65somatic hypermutation of immunoglobulin genes (GO:0016446)3.19347973
66negative regulation of organelle assembly (GO:1902116)3.14869149
67single strand break repair (GO:0000012)3.13041583
68centriole replication (GO:0007099)3.12771721
69regulation of hippo signaling (GO:0035330)3.10719927
70left/right pattern formation (GO:0060972)3.09781148
71regulation of mesoderm development (GO:2000380)3.09729625
72microtubule-based movement (GO:0007018)3.09085893
73cerebellar Purkinje cell differentiation (GO:0021702)3.08318716
74multicellular organismal reproductive process (GO:0048609)3.07988833
75negative regulation of translation, ncRNA-mediated (GO:0040033)3.00375965
76regulation of translation, ncRNA-mediated (GO:0045974)3.00375965
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.00375965
78microtubule polymerization or depolymerization (GO:0031109)2.99662603
79monoubiquitinated protein deubiquitination (GO:0035520)2.98803829
80centriole assembly (GO:0098534)2.96418811
81seminiferous tubule development (GO:0072520)2.95195864
82lymphangiogenesis (GO:0001946)2.92880504
83behavioral response to nicotine (GO:0035095)2.91884521
84protein targeting to Golgi (GO:0000042)2.89123694
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88866247
86DNA double-strand break processing (GO:0000729)2.88712572
87organic cation transport (GO:0015695)2.87989061
88regulation of protein polyubiquitination (GO:1902914)2.86022562
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85872797
90* protein polyglutamylation (GO:0018095)2.84501834
91cilium organization (GO:0044782)2.84112535
92L-fucose catabolic process (GO:0042355)2.83771444
93fucose catabolic process (GO:0019317)2.83771444
94L-fucose metabolic process (GO:0042354)2.83771444
95cilium morphogenesis (GO:0060271)2.82904399
96retrograde transport, vesicle recycling within Golgi (GO:0000301)2.82474830
97regulation of centriole replication (GO:0046599)2.81500546
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80684524
99isotype switching (GO:0045190)2.80684524
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80684524
101microtubule organizing center organization (GO:0031023)2.79769943
102microtubule nucleation (GO:0007020)2.79109327
103regulation of telomere maintenance (GO:0032204)2.79077531
104cilium assembly (GO:0042384)2.76776111
105DNA replication-dependent nucleosome assembly (GO:0006335)2.76494390
106DNA replication-dependent nucleosome organization (GO:0034723)2.76494390
107membrane depolarization during action potential (GO:0086010)2.76475951
108centrosome organization (GO:0051297)2.75071855
109protein K6-linked ubiquitination (GO:0085020)2.74854801
110establishment of protein localization to Golgi (GO:0072600)2.74392642
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72967818
112regulation of centrosome cycle (GO:0046605)2.71998572
113regulation of gene silencing by RNA (GO:0060966)2.71356881
114regulation of posttranscriptional gene silencing (GO:0060147)2.71356881
115regulation of gene silencing by miRNA (GO:0060964)2.71356881
116regulation of centrosome duplication (GO:0010824)2.71246957
117synapsis (GO:0007129)2.70812614
118preassembly of GPI anchor in ER membrane (GO:0016254)2.68993487
119DNA packaging (GO:0006323)2.68519639
120spermatid nucleus differentiation (GO:0007289)2.68298122
121genitalia morphogenesis (GO:0035112)2.68297451
122regulation of nuclear cell cycle DNA replication (GO:0033262)2.66430146
123negative regulation of DNA-dependent DNA replication (GO:2000104)2.65917161
124regulation of spindle checkpoint (GO:0090231)2.65020509
125chromatin remodeling at centromere (GO:0031055)2.64552532
126calcium ion import (GO:0070509)2.64388008
127* cellular component assembly involved in morphogenesis (GO:0010927)2.64072078
128sulfation (GO:0051923)2.63126815
129otic vesicle formation (GO:0030916)2.63016216
130detection of light stimulus involved in sensory perception (GO:0050962)2.61598126
131detection of light stimulus involved in visual perception (GO:0050908)2.61598126
132double-strand break repair (GO:0006302)2.61459320
133gene silencing by RNA (GO:0031047)2.60101612
134* axoneme assembly (GO:0035082)2.58242192
135myelination (GO:0042552)2.56977018
136CENP-A containing nucleosome assembly (GO:0034080)2.56684795
137ncRNA catabolic process (GO:0034661)2.56480262
138reciprocal meiotic recombination (GO:0007131)2.56275029
139reciprocal DNA recombination (GO:0035825)2.56275029
140photoreceptor cell development (GO:0042461)2.56083494
141eye photoreceptor cell development (GO:0042462)2.55964926
142eye photoreceptor cell differentiation (GO:0001754)2.55100620
143photoreceptor cell differentiation (GO:0046530)2.55100620
144meiotic cell cycle process (GO:1903046)2.54262529
145mitochondrial respiratory chain complex I assembly (GO:0032981)2.54058540
146NADH dehydrogenase complex assembly (GO:0010257)2.54058540
147mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54058540
148ensheathment of neurons (GO:0007272)2.53497620
149axon ensheathment (GO:0008366)2.53497620
150negative regulation of systemic arterial blood pressure (GO:0003085)2.52752954
151detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.51314923
152negative regulation of telomere maintenance (GO:0032205)2.50670701
153L-amino acid import (GO:0043092)2.50538037
154somatic diversification of immunoglobulins (GO:0016445)2.50351152
155DNA methylation (GO:0006306)2.50256506
156DNA alkylation (GO:0006305)2.50256506
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50032612
158response to pheromone (GO:0019236)2.49787392
159centrosome duplication (GO:0051298)2.43463569
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.42123161
161neuron cell-cell adhesion (GO:0007158)2.38259516
162multicellular organismal development (GO:0007275)2.36866903
163mitotic sister chromatid cohesion (GO:0007064)2.36790412
164cerebellar granule cell differentiation (GO:0021707)2.35504777
165cilium or flagellum-dependent cell motility (GO:0001539)10.3847082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.30427167
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.95898097
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62456231
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86995304
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.85033424
6E2F7_22180533_ChIP-Seq_HELA_Human2.64450539
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.64011768
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.62618290
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.56474419
10GBX2_23144817_ChIP-Seq_PC3_Human2.40727256
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.37793248
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.34081654
13EWS_26573619_Chip-Seq_HEK293_Human1.98444532
14* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91471440
15* CBP_20019798_ChIP-Seq_JUKART_Human1.91471440
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87112593
17E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82487559
18DROSHA_22980978_ChIP-Seq_HELA_Human1.81349629
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.79276821
20REST_21632747_ChIP-Seq_MESCs_Mouse1.76543739
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75888300
22IGF1R_20145208_ChIP-Seq_DFB_Human1.74924821
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71641165
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.71288059
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66289886
26IRF1_19129219_ChIP-ChIP_H3396_Human1.66102012
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63850476
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59322999
29ZNF274_21170338_ChIP-Seq_K562_Hela1.58180247
30TCF4_23295773_ChIP-Seq_U87_Human1.57877144
31* SMAD4_21799915_ChIP-Seq_A2780_Human1.54792445
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54247017
33TP63_19390658_ChIP-ChIP_HaCaT_Human1.53789586
34* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.51289119
35VDR_22108803_ChIP-Seq_LS180_Human1.50598565
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50244843
37STAT3_23295773_ChIP-Seq_U87_Human1.48870491
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.48789364
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47211611
40MYC_18940864_ChIP-ChIP_HL60_Human1.46555359
41AR_21572438_ChIP-Seq_LNCaP_Human1.46302405
42AHR_22903824_ChIP-Seq_MCF-7_Human1.45956680
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.44814272
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44762719
45* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44623070
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43789903
47* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43400003
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43028707
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42968540
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41222568
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41222568
52* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40239530
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38854518
54* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37554869
55TAF15_26573619_Chip-Seq_HEK293_Human1.35674308
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35436112
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.35269706
58RNF2_27304074_Chip-Seq_NSC_Mouse1.34013066
59* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.33837527
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.32274268
61TCF4_22108803_ChIP-Seq_LS180_Human1.31441212
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31172440
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.29289554
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29263755
65BCAT_22108803_ChIP-Seq_LS180_Human1.28656919
66TBL1_22424771_ChIP-Seq_293T_Human1.27628086
67EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25544799
68* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24620256
69CMYC_18555785_Chip-Seq_ESCs_Mouse1.24022616
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23872902
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22984579
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22979640
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.22774337
74FUS_26573619_Chip-Seq_HEK293_Human1.22133057
75RUNX2_22187159_ChIP-Seq_PCA_Human1.22124253
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22004591
77* ER_23166858_ChIP-Seq_MCF-7_Human1.21907840
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21765814
79TP53_22573176_ChIP-Seq_HFKS_Human1.21678940
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.21416869
81P53_22387025_ChIP-Seq_ESCs_Mouse1.21324515
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.21061958
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21046732
84KDM2B_26808549_Chip-Seq_REH_Human1.19468582
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.17838724
86ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16722247
87P300_18555785_Chip-Seq_ESCs_Mouse1.16579038
88KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16500099
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.16370703
90NANOG_19829295_ChIP-Seq_ESCs_Human1.16026247
91SOX2_19829295_ChIP-Seq_ESCs_Human1.16026247
92* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15240805
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14700177
94OCT4_18555785_Chip-Seq_ESCs_Mouse1.14430936
95STAT3_18555785_Chip-Seq_ESCs_Mouse1.13904626
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.12570341
97HOXB7_26014856_ChIP-Seq_BT474_Human1.12156169
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11583149
99KLF4_18555785_Chip-Seq_ESCs_Mouse1.11290782
100EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10797405
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.09947216
102CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09569316
103* SMAD3_21741376_ChIP-Seq_EPCs_Human1.09329530
104KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.09302163
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09225812
106PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08510057
107ELK1_19687146_ChIP-ChIP_HELA_Human1.08112589
108GF1_26923725_Chip-Seq_HPCs_Mouse1.08050546
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06824307
110TDRD3_21172665_ChIP-Seq_MCF-7_Human1.06207111
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05822891
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05428392
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.05418329
114RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05020883
115P300_19829295_ChIP-Seq_ESCs_Human1.04845586
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04827960
117NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04740207
118AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04498385
119FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04236020
120* SOX9_26525672_Chip-Seq_HEART_Mouse1.04023551
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.03906153
122NCOR_22424771_ChIP-Seq_293T_Human1.03627873
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.03246618
124CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02393673
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02298665
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02022110
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.02022110
128* FLI1_21867929_ChIP-Seq_TH2_Mouse1.01952833
129SOX2_18555785_Chip-Seq_ESCs_Mouse1.01888465
130TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01797533
131NMYC_18555785_Chip-Seq_ESCs_Mouse1.01319972
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01059300
133AR_25329375_ChIP-Seq_VCAP_Human1.00421231
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.00381419
135CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99990778
136* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99985258
137ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99836216
138WDR5_24793694_ChIP-Seq_LNCAP_Human0.99148085
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98868244
140PU1_27457419_Chip-Seq_LIVER_Mouse0.98281823
141ETV1_20927104_ChIP-Seq_GIST48_Human0.98157652
142NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97944454
143CDX2_22108803_ChIP-Seq_LS180_Human0.97943078
144NFYB_21822215_ChIP-Seq_K562_Human0.97917703
145NOTCH1_21737748_ChIP-Seq_TLL_Human0.97862981
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96609954
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.96266611

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.20157519
2MP0008877_abnormal_DNA_methylation4.65957851
3MP0003698_abnormal_male_reproductive3.90985652
4MP0001929_abnormal_gametogenesis3.44285920
5MP0009046_muscle_twitch2.85208536
6MP0002210_abnormal_sex_determination2.52816375
7MP0005377_hearing/vestibular/ear_phenot2.51858359
8MP0003878_abnormal_ear_physiology2.51858359
9MP0004270_analgesia2.26120919
10MP0005551_abnormal_eye_electrophysiolog2.12141666
11MP0002161_abnormal_fertility/fecundity2.09640535
12MP0004859_abnormal_synaptic_plasticity2.08167063
13MP0001145_abnormal_male_reproductive2.03390280
14MP0003950_abnormal_plasma_membrane2.03101699
15MP0005423_abnormal_somatic_nervous1.98457713
16MP0000569_abnormal_digit_pigmentation1.96220129
17MP0002272_abnormal_nervous_system1.95180086
18MP0003718_maternal_effect1.89498940
19MP0001486_abnormal_startle_reflex1.88241876
20MP0008872_abnormal_physiological_respon1.85670416
21MP0002653_abnormal_ependyma_morphology1.84737481
22MP0000920_abnormal_myelination1.83314638
23MP0000653_abnormal_sex_gland1.83204249
24MP0003787_abnormal_imprinting1.82311614
25MP0005623_abnormal_meninges_morphology1.80813109
26MP0008057_abnormal_DNA_replication1.77294840
27MP0001984_abnormal_olfaction1.76419575
28MP0003693_abnormal_embryo_hatching1.74517395
29MP0008569_lethality_at_weaning1.71997962
30MP0004147_increased_porphyrin_level1.64805382
31MP0005171_absent_coat_pigmentation1.63904169
32MP0000427_abnormal_hair_cycle1.62646237
33MP0003635_abnormal_synaptic_transmissio1.61325434
34MP0004742_abnormal_vestibular_system1.59203026
35MP0003786_premature_aging1.57127622
36MP0003880_abnormal_central_pattern1.55376809
37MP0005083_abnormal_biliary_tract1.55138723
38MP0003195_calcinosis1.52863866
39MP0002160_abnormal_reproductive_system1.52660315
40MP0000383_abnormal_hair_follicle1.51560274
41MP0003937_abnormal_limbs/digits/tail_de1.51496646
42MP0000049_abnormal_middle_ear1.45635687
43MP0002734_abnormal_mechanical_nocicepti1.45016896
44MP0002938_white_spotting1.43353103
45MP0002064_seizures1.40883634
46MP0000372_irregular_coat_pigmentation1.40012156
47MP0005253_abnormal_eye_physiology1.39620431
48MP0001986_abnormal_taste_sensitivity1.37606002
49MP0009697_abnormal_copulation1.31560693
50MP0002067_abnormal_sensory_capabilities1.31195680
51MP0006072_abnormal_retinal_apoptosis1.31066003
52MP0002229_neurodegeneration1.29604822
53MP0000778_abnormal_nervous_system1.25624361
54MP0002282_abnormal_trachea_morphology1.25288221
55MP0005075_abnormal_melanosome_morpholog1.24412486
56MP0001293_anophthalmia1.24345385
57MP0004885_abnormal_endolymph1.23048150
58MP0002572_abnormal_emotion/affect_behav1.22861297
59MP0001968_abnormal_touch/_nociception1.22278095
60MP0009745_abnormal_behavioral_response1.21970806
61MP0009250_abnormal_appendicular_skeleto1.21229582
62MP0005646_abnormal_pituitary_gland1.20733149
63MP0001440_abnormal_grooming_behavior1.19621623
64MP0008995_early_reproductive_senescence1.16541192
65MP0002876_abnormal_thyroid_physiology1.16435594
66MP0003077_abnormal_cell_cycle1.15602894
67MP0005645_abnormal_hypothalamus_physiol1.15438569
68MP0002735_abnormal_chemical_nociception1.14099231
69MP0002234_abnormal_pharynx_morphology1.13975570
70MP0001299_abnormal_eye_distance/1.13829992
71MP0000462_abnormal_digestive_system1.13491068
72MP0000955_abnormal_spinal_cord1.12363083
73MP0002063_abnormal_learning/memory/cond1.11982954
74MP0009053_abnormal_anal_canal1.10477843
75MP0001919_abnormal_reproductive_system1.10374384
76MP0002882_abnormal_neuron_morphology1.09883224
77MP0003111_abnormal_nucleus_morphology1.08883950
78MP0010368_abnormal_lymphatic_system1.08248384
79MP0003119_abnormal_digestive_system1.07847084
80MP0003632_abnormal_nervous_system1.06575319
81MP0002736_abnormal_nociception_after1.05343493
82MP0003634_abnormal_glial_cell1.05020947
83MP0004957_abnormal_blastocyst_morpholog1.03938869
84MP0002102_abnormal_ear_morphology1.03258571
85MP0005174_abnormal_tail_pigmentation1.02397419
86MP0004134_abnormal_chest_morphology1.01695682
87MP0005379_endocrine/exocrine_gland_phen1.00778554
88MP0003890_abnormal_embryonic-extraembry1.00428373
89MP0008932_abnormal_embryonic_tissue0.99226066
90MP0008789_abnormal_olfactory_epithelium0.98588118
91MP0005395_other_phenotype0.98578265
92MP0003690_abnormal_glial_cell0.97512671
93MP0002184_abnormal_innervation0.94476091
94MP0001188_hyperpigmentation0.94189837
95MP0002752_abnormal_somatic_nervous0.94002736
96MP0001485_abnormal_pinna_reflex0.93178983
97MP0003936_abnormal_reproductive_system0.92936381
98MP0004145_abnormal_muscle_electrophysio0.92580295
99MP0001963_abnormal_hearing_physiology0.92576460
100MP0004233_abnormal_muscle_weight0.92552682
101MP0005367_renal/urinary_system_phenotyp0.92538375
102MP0000516_abnormal_urinary_system0.92538375
103MP0009780_abnormal_chondrocyte_physiolo0.91651057
104MP0002557_abnormal_social/conspecific_i0.88521002
105MP0003045_fibrosis0.88390177
106MP0001502_abnormal_circadian_rhythm0.88351586
107MP0002152_abnormal_brain_morphology0.88319934
108MP0004142_abnormal_muscle_tone0.87756738
109MP0002928_abnormal_bile_duct0.87519402
110MP0002163_abnormal_gland_morphology0.86957423
111MP0003011_delayed_dark_adaptation0.86900982
112MP0004811_abnormal_neuron_physiology0.86761423
113MP0003646_muscle_fatigue0.86033785
114MP0003631_nervous_system_phenotype0.85693889
115MP0002138_abnormal_hepatobiliary_system0.84582171
116MP0008260_abnormal_autophagy0.83854139
117MP0008058_abnormal_DNA_repair0.83520405
118MP0001119_abnormal_female_reproductive0.82399436
119MP0002066_abnormal_motor_capabilities/c0.81318923
120MP0003183_abnormal_peptide_metabolism0.80773098
121MP0002932_abnormal_joint_morphology0.79944458
122MP0004043_abnormal_pH_regulation0.79753581
123MP0001970_abnormal_pain_threshold0.78423603
124MP0008007_abnormal_cellular_replicative0.78102743
125MP0010307_abnormal_tumor_latency0.77782110
126MP0000026_abnormal_inner_ear0.77449377
127MP0001286_abnormal_eye_development0.77298224
128MP0004133_heterotaxia0.77295707
129MP0005391_vision/eye_phenotype0.76561479
130MP0003942_abnormal_urinary_system0.76142635
131MP0001529_abnormal_vocalization0.75714058
132MP0002109_abnormal_limb_morphology0.75585889
133MP0005195_abnormal_posterior_eye0.75529329
134MP0000613_abnormal_salivary_gland0.75378914
135MP0002751_abnormal_autonomic_nervous0.75022000
136MP0002733_abnormal_thermal_nociception0.73691200
137MP0005409_darkened_coat_color0.72972346
138MP0000015_abnormal_ear_pigmentation0.71588623
139MP0003879_abnormal_hair_cell0.70648534
140MP0003633_abnormal_nervous_system0.70268097
141MP0003861_abnormal_nervous_system0.68389599
142MP0002108_abnormal_muscle_morphology0.67054634
143MP0010094_abnormal_chromosome_stability0.66790746
144MP0000566_synostosis0.65577884
145MP0000631_abnormal_neuroendocrine_gland0.65407500
146MP0003329_amyloid_beta_deposits0.65166868
147MP0005670_abnormal_white_adipose0.61062598
148MP0005389_reproductive_system_phenotype0.60636710
149MP0003121_genomic_imprinting0.59226580
150MP0005386_behavior/neurological_phenoty0.59155994
151MP0004924_abnormal_behavior0.59155994
152MP0001324_abnormal_eye_pigmentation0.55403773
153MP0006292_abnormal_olfactory_placode0.53276319

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.65678305
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.06971793
3Absent/shortened dynein arms (HP:0200106)9.06971793
4Abnormal respiratory motile cilium physiology (HP:0012261)6.73374428
5Abnormal respiratory motile cilium morphology (HP:0005938)6.06550830
6Abnormal respiratory epithelium morphology (HP:0012253)6.06550830
7Abnormal ciliary motility (HP:0012262)5.53827717
8Rhinitis (HP:0012384)5.45374055
9Chronic bronchitis (HP:0004469)4.48107995
10Infertility (HP:0000789)4.34663551
11Pancreatic cysts (HP:0001737)4.04808230
12Nephronophthisis (HP:0000090)3.73095928
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.36973720
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32658839
15Bronchiectasis (HP:0002110)3.08270766
16Chromsome breakage (HP:0040012)3.06489498
17Degeneration of the lateral corticospinal tracts (HP:0002314)2.97588130
18Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.97588130
19Abnormality of the renal medulla (HP:0100957)2.96649422
20Abnormality of the ileum (HP:0001549)2.93647885
21Tubulointerstitial nephritis (HP:0001970)2.91984599
22Gaze-evoked nystagmus (HP:0000640)2.91325558
23Meckel diverticulum (HP:0002245)2.90709825
24Abnormality of chromosome stability (HP:0003220)2.85689821
25Severe visual impairment (HP:0001141)2.83546724
26Nasal polyposis (HP:0100582)2.81389340
27Male infertility (HP:0003251)2.80231988
28Pendular nystagmus (HP:0012043)2.78256961
29Sclerocornea (HP:0000647)2.75471294
30Abnormality of the lower motor neuron (HP:0002366)2.74798777
31Progressive cerebellar ataxia (HP:0002073)2.74424172
32Cystic liver disease (HP:0006706)2.73990377
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.72187700
34Abolished electroretinogram (ERG) (HP:0000550)2.72162029
35Abnormality of the renal cortex (HP:0011035)2.65226472
36Abnormality of the corticospinal tract (HP:0002492)2.61933065
37Abnormality of the preputium (HP:0100587)2.59690000
38Abnormality of midbrain morphology (HP:0002418)2.51785397
39Molar tooth sign on MRI (HP:0002419)2.51785397
40Medial flaring of the eyebrow (HP:0010747)2.45710214
41Keratoconus (HP:0000563)2.45252909
42Increased corneal curvature (HP:0100692)2.45252909
43Anencephaly (HP:0002323)2.42969165
44Bronchitis (HP:0012387)2.40875140
45Abnormal rod and cone electroretinograms (HP:0008323)2.39845561
46Abnormality of the renal collecting system (HP:0004742)2.39398070
47Dyschromatopsia (HP:0007641)2.39207616
48Absent thumb (HP:0009777)2.38049448
49Fibular hypoplasia (HP:0003038)2.37179320
50Sloping forehead (HP:0000340)2.36680764
51Small hand (HP:0200055)2.36321330
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.33542165
53Clubbing of toes (HP:0100760)2.33182937
54Recurrent otitis media (HP:0000403)2.30327593
55Abnormality of the proximal phalanges of the hand (HP:0009834)2.28973842
56Bell-shaped thorax (HP:0001591)2.28598821
57Abnormality of the carotid arteries (HP:0005344)2.28527985
58Abnormality of DNA repair (HP:0003254)2.28272913
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.27791181
60Small intestinal stenosis (HP:0012848)2.26334459
61Duodenal stenosis (HP:0100867)2.26334459
62Action tremor (HP:0002345)2.25522484
63Congenital stationary night blindness (HP:0007642)2.18840352
64Decreased central vision (HP:0007663)2.15417072
65Choroideremia (HP:0001139)2.13506431
66Spastic gait (HP:0002064)2.13413094
67Postaxial foot polydactyly (HP:0001830)2.12861167
68Peripheral hypomyelination (HP:0007182)2.11591585
69Volvulus (HP:0002580)2.10589773
70Epileptic encephalopathy (HP:0200134)2.10271969
71Abnormal spermatogenesis (HP:0008669)2.08182501
72Preaxial hand polydactyly (HP:0001177)2.05235054
73Methylmalonic acidemia (HP:0002912)2.04013307
74Bony spicule pigmentary retinopathy (HP:0007737)2.03972847
75Duplicated collecting system (HP:0000081)2.01964692
76Asplenia (HP:0001746)2.01105175
77Oligohydramnios (HP:0001562)1.97716790
78Abnormality of ocular smooth pursuit (HP:0000617)1.97142756
79Short tibia (HP:0005736)1.97065053
80Decreased motor nerve conduction velocity (HP:0003431)1.96712992
81Male pseudohermaphroditism (HP:0000037)1.96578903
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.96578874
83Aplasia/Hypoplasia of the spleen (HP:0010451)1.96092733
84Renal cortical cysts (HP:0000803)1.95945621
85Abnormality of the duodenum (HP:0002246)1.95869780
86Thyroiditis (HP:0100646)1.95272287
87Astigmatism (HP:0000483)1.95249688
88Abnormality of the nasal septum (HP:0000419)1.94259217
89Heterotopia (HP:0002282)1.93787187
90Ectopic kidney (HP:0000086)1.93166797
91Amyotrophic lateral sclerosis (HP:0007354)1.88598909
92Atonic seizures (HP:0010819)1.85654944
93Abnormality of macular pigmentation (HP:0008002)1.85221103
94Abnormality of the nasal mucosa (HP:0000433)1.84028020
95Febrile seizures (HP:0002373)1.83241319
96Dysmetria (HP:0001310)1.82186285
97Chronic hepatic failure (HP:0100626)1.81037675
98Occipital encephalocele (HP:0002085)1.80826471
99Retinal dysplasia (HP:0007973)1.80710113
100Intellectual disability, moderate (HP:0002342)1.80111797
101Abnormality of the dental root (HP:0006486)1.79791012
102Taurodontia (HP:0000679)1.79791012
103Abnormality of permanent molar morphology (HP:0011071)1.79791012
104Dysdiadochokinesis (HP:0002075)1.79398619
105Type II lissencephaly (HP:0007260)1.79350666
106Severe combined immunodeficiency (HP:0004430)1.78989787
107Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78526519
108Onion bulb formation (HP:0003383)1.77659549
109Impaired vibration sensation in the lower limbs (HP:0002166)1.77310139
110Impulsivity (HP:0100710)1.76968387
111Abnormality of molar morphology (HP:0011070)1.75938838
112Abnormality of molar (HP:0011077)1.75938838
113Scanning speech (HP:0002168)1.75602149
114Genital tract atresia (HP:0001827)1.74875978
115Gait imbalance (HP:0002141)1.74097155
116Urinary bladder sphincter dysfunction (HP:0002839)1.73708517
117Congenital hepatic fibrosis (HP:0002612)1.73165769
118Absent frontal sinuses (HP:0002688)1.72898179
119Aplasia/Hypoplasia of the lens (HP:0008063)1.72347677
120Tubulointerstitial abnormality (HP:0001969)1.71877735
121Abnormality of the dental pulp (HP:0006479)1.71537158
122Postaxial hand polydactyly (HP:0001162)1.71085868
123Cutaneous finger syndactyly (HP:0010554)1.70650710
124Adactyly (HP:0009776)1.70611123
125Spastic tetraparesis (HP:0001285)1.70414645
126Gonadotropin excess (HP:0000837)1.70192899
127Supernumerary spleens (HP:0009799)1.70118582
128Carpal bone hypoplasia (HP:0001498)1.69641639
129Glioma (HP:0009733)1.69314621
130Genetic anticipation (HP:0003743)1.69113687
131Pancreatic fibrosis (HP:0100732)1.69037107
132Ankle clonus (HP:0011448)1.68934490
133Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.68916311
134Abnormality of saccadic eye movements (HP:0000570)1.68645884
135Hemiparesis (HP:0001269)1.68450668
136Triphalangeal thumb (HP:0001199)1.68369686
137Recurrent sinusitis (HP:0011108)1.66644243
138Attenuation of retinal blood vessels (HP:0007843)1.66624184
139Supranuclear gaze palsy (HP:0000605)1.66196367
140Cone-rod dystrophy (HP:0000548)1.65500948
141Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65466904
142Hypoplasia of the uterus (HP:0000013)1.65412465
143Aplasia/Hypoplasia of the fibula (HP:0006492)1.65190585
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65102489
145Furrowed tongue (HP:0000221)1.64860400
146Congenital primary aphakia (HP:0007707)1.64841353
147Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64700343
148Azoospermia (HP:0000027)1.64426493
149Hypoplastic iliac wings (HP:0002866)1.64354267
150Stage 5 chronic kidney disease (HP:0003774)1.63138512
151Hypoplasia of the capital femoral epiphysis (HP:0003090)1.63014747
152Vaginal atresia (HP:0000148)1.62902179
153Truncal obesity (HP:0001956)1.62585116
154Intention tremor (HP:0002080)1.61617022
155Nephroblastoma (Wilms tumor) (HP:0002667)1.60619019
156Abnormality of the phalanges of the 5th finger (HP:0004213)1.60255813
157Tubular atrophy (HP:0000092)1.58995566
158Abnormality of the astrocytes (HP:0100707)1.58987609
159Impaired vibratory sensation (HP:0002495)1.57747179
160Myokymia (HP:0002411)1.57148545
161Polydipsia (HP:0001959)1.56607125
162Abnormal drinking behavior (HP:0030082)1.56607125
163True hermaphroditism (HP:0010459)1.56131936
164Neurofibrillary tangles (HP:0002185)1.55955979
165Lower limb muscle weakness (HP:0007340)1.55377557
166Absent speech (HP:0001344)1.54778201
167Median cleft lip (HP:0000161)1.54571219
168Abnormal auditory evoked potentials (HP:0006958)1.52559612

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.12903948
2PDK35.12903948
3PLK44.25676476
4STK394.00271889
5FRK3.99039450
6PDK23.98973262
7NUAK13.50343286
8PRKD33.44070652
9ICK3.01902545
10MAP4K22.98506128
11PNCK2.76317878
12TLK12.70887073
13WNK12.66376942
14TESK12.65134209
15CAMK1G2.64112454
16WNK42.56042989
17ACVR1B2.18221724
18ADRBK21.84396811
19PLK21.81178392
20CAMK1D1.80416010
21TIE11.79944464
22NEK61.75222527
23TXK1.71447974
24OXSR11.56127555
25PTK2B1.50578500
26STK381.47984441
27MAPKAPK51.44793569
28TNIK1.42455697
29MST41.41032324
30CAMKK21.35341852
31TRIM281.31912730
32INSRR1.30249182
33VRK21.26726287
34VRK11.22876673
35MKNK21.20852533
36TAOK31.19826056
37WEE11.19188048
38CDK121.18195675
39CASK1.14790910
40TAF11.14108934
41MARK21.14095139
42STK38L1.13283537
43PKN11.12598416
44BMPR1B1.12526166
45TTK1.12278512
46STK31.12133129
47PRPF4B1.06997961
48EIF2AK31.06980993
49SGK4941.06382618
50SGK2231.06382618
51PAK61.06055824
52CDK31.05844801
53BRSK21.04705029
54NEK21.04667658
55PINK11.03315341
56PLK11.02476979
57NTRK21.01479927
58NTRK30.97713408
59TGFBR10.97197157
60MAPK150.93348783
61PLK30.91364039
62MAP2K20.91101180
63MUSK0.91066481
64MAP3K40.90425718
65BUB10.90060231
66EPHB10.88839441
67MAPK130.85685482
68FGFR20.85371242
69GRK10.84239585
70CDK80.81167960
71CLK10.78981377
72CSNK1G20.73948487
73TEC0.73853617
74PRKCE0.72775179
75CAMKK10.72032333
76CAMK10.70664012
77TYRO30.70050809
78SGK20.69880234
79EIF2AK20.68652880
80PDK10.68271040
81PBK0.66720563
82CDC70.66414025
83CSNK1G10.65123932
84CHEK20.64642533
85MAP3K60.64381405
86LMTK20.61709846
87NME10.60684299
88PRKCI0.60067596
89MKNK10.59547205
90CHEK10.59203869
91KDR0.59194179
92IRAK10.59075600
93TSSK60.58972512
94MAP2K70.58781948
95CSNK1A1L0.58257011
96CCNB10.57837224
97CDK70.57548940
98EEF2K0.56654865
99AURKB0.56314973
100SRPK10.54743560
101NEK10.54453461
102AURKA0.50310475
103ATM0.50011769
104TRPM70.49970637
105ZAK0.49899788
106CSNK1G30.48108359
107ATR0.47949486
108FER0.47063219
109DYRK20.46884678
110CDK50.46441927
111SGK30.46383592
112UHMK10.46002427
113BCR0.45433020
114LATS10.44933366
115PAK30.43838813
116PRKAA10.43688524
117BRD40.43581344
118IRAK20.43539174
119CSNK1A10.43136673
120BCKDK0.41754772
121GSK3B0.41400809
122CHUK0.41110532
123MAPK100.40590287
124ERBB30.40514933
125CAMK2D0.40276686
126IGF1R0.39073050
127MINK10.38859958
128CDK20.37782440
129MAP2K10.37722661
130CAMK2B0.37581228
131MTOR0.37533685
132CDC42BPA0.36994757
133MAPK70.36993844
134PIK3CA0.36927554
135CAMK2A0.36540341
136ADRBK10.36402155
137PDPK10.36156055
138PRKCG0.36071588
139PRKG10.35825575
140MARK10.35428698
141EIF2AK10.35381852
142BRSK10.34745160
143CSNK1D0.34066804
144SGK10.33385834
145WNK30.32710838
146STK110.32707494
147IKBKB0.32697162
148CDK150.32602921
149AKT30.32043392
150CDK180.31191214
151CDK10.30812546
152MAPK80.30662243
153RPS6KB10.30600554
154NLK0.29455791
155CDK90.29158040
156RPS6KA50.29097059
157ROCK20.28614921
158CDK11A0.27965776
159TESK20.27340996
160PRKDC0.27207189
161RPS6KA30.26833083

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.14545112
2Vitamin B6 metabolism_Homo sapiens_hsa007503.02658543
3DNA replication_Homo sapiens_hsa030302.54551606
4Dorso-ventral axis formation_Homo sapiens_hsa043202.50415430
5Mismatch repair_Homo sapiens_hsa034302.50404940
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49329200
7Nicotine addiction_Homo sapiens_hsa050332.38573754
8RNA polymerase_Homo sapiens_hsa030202.26810626
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.23911078
10Glutamatergic synapse_Homo sapiens_hsa047242.13111933
11Nucleotide excision repair_Homo sapiens_hsa034202.09898981
12Fanconi anemia pathway_Homo sapiens_hsa034602.02609480
13Taste transduction_Homo sapiens_hsa047421.83841305
14Amphetamine addiction_Homo sapiens_hsa050311.83601915
15RNA transport_Homo sapiens_hsa030131.81988934
16Circadian entrainment_Homo sapiens_hsa047131.81744237
17Fatty acid biosynthesis_Homo sapiens_hsa000611.79263614
18Morphine addiction_Homo sapiens_hsa050321.79075888
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.78897896
20Base excision repair_Homo sapiens_hsa034101.74720649
21RNA degradation_Homo sapiens_hsa030181.74238060
22Basal transcription factors_Homo sapiens_hsa030221.71882237
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.71859360
24One carbon pool by folate_Homo sapiens_hsa006701.70838581
25Synaptic vesicle cycle_Homo sapiens_hsa047211.70032707
26Nitrogen metabolism_Homo sapiens_hsa009101.69216840
27Olfactory transduction_Homo sapiens_hsa047401.66352268
28Salivary secretion_Homo sapiens_hsa049701.66287548
29Insulin secretion_Homo sapiens_hsa049111.65838642
30Selenocompound metabolism_Homo sapiens_hsa004501.61452167
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60534929
32Ether lipid metabolism_Homo sapiens_hsa005651.60436156
33Long-term potentiation_Homo sapiens_hsa047201.59515127
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.55521364
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53984735
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52280445
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51978060
38GABAergic synapse_Homo sapiens_hsa047271.49636936
39Oocyte meiosis_Homo sapiens_hsa041141.44027770
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43953643
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41539635
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39443673
43Linoleic acid metabolism_Homo sapiens_hsa005911.37622133
44Renin secretion_Homo sapiens_hsa049241.36857562
45Inositol phosphate metabolism_Homo sapiens_hsa005621.36799797
46Butanoate metabolism_Homo sapiens_hsa006501.30840749
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30471408
48Pyrimidine metabolism_Homo sapiens_hsa002401.30296683
49Glucagon signaling pathway_Homo sapiens_hsa049221.28424655
50Propanoate metabolism_Homo sapiens_hsa006401.24930879
51Gastric acid secretion_Homo sapiens_hsa049711.24481463
52Calcium signaling pathway_Homo sapiens_hsa040201.20780022
53cAMP signaling pathway_Homo sapiens_hsa040241.20648600
54Glycerophospholipid metabolism_Homo sapiens_hsa005641.20145183
55Dopaminergic synapse_Homo sapiens_hsa047281.17896759
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.15793739
57Chemical carcinogenesis_Homo sapiens_hsa052041.15331146
58Long-term depression_Homo sapiens_hsa047301.15144567
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14283037
60Sphingolipid metabolism_Homo sapiens_hsa006001.11619297
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10936592
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09640311
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07598637
64Maturity onset diabetes of the young_Homo sapiens_hsa049501.07237647
65Spliceosome_Homo sapiens_hsa030401.05588552
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05319650
67Serotonergic synapse_Homo sapiens_hsa047261.02100467
68mRNA surveillance pathway_Homo sapiens_hsa030151.01114839
69Tryptophan metabolism_Homo sapiens_hsa003800.99211320
70Pancreatic secretion_Homo sapiens_hsa049720.99066933
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98535038
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97760189
73Axon guidance_Homo sapiens_hsa043600.97608148
74Mineral absorption_Homo sapiens_hsa049780.97569071
75Cholinergic synapse_Homo sapiens_hsa047250.95588993
76Proteasome_Homo sapiens_hsa030500.94993421
77Oxytocin signaling pathway_Homo sapiens_hsa049210.94560185
78Type II diabetes mellitus_Homo sapiens_hsa049300.93946429
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93867171
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.92859643
81Retinol metabolism_Homo sapiens_hsa008300.91951278
82Caffeine metabolism_Homo sapiens_hsa002320.91789169
83Estrogen signaling pathway_Homo sapiens_hsa049150.90856370
84Systemic lupus erythematosus_Homo sapiens_hsa053220.90097228
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87750775
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.87434635
87Ovarian steroidogenesis_Homo sapiens_hsa049130.85992186
88Thyroid hormone synthesis_Homo sapiens_hsa049180.85488010
89Cocaine addiction_Homo sapiens_hsa050300.85358400
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84017158
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.81630811
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80907116
93Huntingtons disease_Homo sapiens_hsa050160.80243348
94Endocytosis_Homo sapiens_hsa041440.79515647
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79411263
96Hedgehog signaling pathway_Homo sapiens_hsa043400.79311520
97Primary immunodeficiency_Homo sapiens_hsa053400.78246987
98beta-Alanine metabolism_Homo sapiens_hsa004100.77580233
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76849317
100ErbB signaling pathway_Homo sapiens_hsa040120.75296137
101Choline metabolism in cancer_Homo sapiens_hsa052310.75260112
102Pyruvate metabolism_Homo sapiens_hsa006200.75058675
103TGF-beta signaling pathway_Homo sapiens_hsa043500.74571208
104Non-homologous end-joining_Homo sapiens_hsa034500.72693444
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72603830
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72197982
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71740162
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71727001
109Wnt signaling pathway_Homo sapiens_hsa043100.69757382
110ABC transporters_Homo sapiens_hsa020100.69359003
111Alcoholism_Homo sapiens_hsa050340.69348876
112MAPK signaling pathway_Homo sapiens_hsa040100.68859943
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67340234
114Peroxisome_Homo sapiens_hsa041460.66631680
115Circadian rhythm_Homo sapiens_hsa047100.65959948
116Steroid biosynthesis_Homo sapiens_hsa001000.64197017
117p53 signaling pathway_Homo sapiens_hsa041150.64004874
118Cardiac muscle contraction_Homo sapiens_hsa042600.63154842
119Glycerolipid metabolism_Homo sapiens_hsa005610.60395312
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59506148
121Hippo signaling pathway_Homo sapiens_hsa043900.59192553
122Ras signaling pathway_Homo sapiens_hsa040140.58094039
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56683686
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55490029
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53372619
126Melanoma_Homo sapiens_hsa052180.51769453
127Cysteine and methionine metabolism_Homo sapiens_hsa002700.51676161
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51013065
129Vitamin digestion and absorption_Homo sapiens_hsa049770.50643329
130Protein export_Homo sapiens_hsa030600.50301356
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47920760
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.47556998
133Gap junction_Homo sapiens_hsa045400.47523708
134Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47275548
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45489260
136Fatty acid metabolism_Homo sapiens_hsa012120.44814433
137Metabolic pathways_Homo sapiens_hsa011000.44527066
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43031361
139Lysine degradation_Homo sapiens_hsa003100.40415907
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39617355
141Regulation of autophagy_Homo sapiens_hsa041400.38340715
142Basal cell carcinoma_Homo sapiens_hsa052170.37942584
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37855189
144GnRH signaling pathway_Homo sapiens_hsa049120.37741651
145Melanogenesis_Homo sapiens_hsa049160.37583196
146Fatty acid elongation_Homo sapiens_hsa000620.37515937
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.36758325
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36605215
149Cell cycle_Homo sapiens_hsa041100.35141695
150Purine metabolism_Homo sapiens_hsa002300.35140400
151Glioma_Homo sapiens_hsa052140.34238474
152Homologous recombination_Homo sapiens_hsa034400.33537873
153Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33303290
154Tight junction_Homo sapiens_hsa045300.32991721
155AMPK signaling pathway_Homo sapiens_hsa041520.32473883
156Arachidonic acid metabolism_Homo sapiens_hsa005900.32022716

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