TTLL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.22944853
2doxorubicin metabolic process (GO:0044598)9.22944853
3daunorubicin metabolic process (GO:0044597)9.22944853
4sperm capacitation (GO:0048240)6.90448931
5fusion of sperm to egg plasma membrane (GO:0007342)6.74566137
6cilium or flagellum-dependent cell motility (GO:0001539)6.55620362
7maintenance of protein location in nucleus (GO:0051457)6.17400433
8regulation of response to osmotic stress (GO:0047484)6.07463477
9aminoglycoside antibiotic metabolic process (GO:0030647)5.92017498
10response to pheromone (GO:0019236)5.84234421
11axoneme assembly (GO:0035082)5.83251943
12axonemal dynein complex assembly (GO:0070286)5.76231808
13* regulation of cilium movement (GO:0003352)5.64215272
14ventricular system development (GO:0021591)5.59148377
15microtubule depolymerization (GO:0007019)5.55467323
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.55381681
17negative regulation of epidermis development (GO:0045683)5.33469720
18single strand break repair (GO:0000012)5.33380900
19somite rostral/caudal axis specification (GO:0032525)5.33133784
20multicellular organism reproduction (GO:0032504)5.19020884
21sperm motility (GO:0030317)5.18641707
22protein localization to kinetochore (GO:0034501)5.15678563
23acrosome assembly (GO:0001675)5.06290761
24regulation of mammary gland epithelial cell proliferation (GO:0033599)5.05090679
25cilium movement (GO:0003341)5.03393565
26motile cilium assembly (GO:0044458)5.02723979
27epithelial cilium movement (GO:0003351)4.98798547
28negative regulation of cell cycle G2/M phase transition (GO:1902750)4.96683762
29plasma membrane fusion (GO:0045026)4.93557164
30regulation of telomere maintenance via telomerase (GO:0032210)4.93075956
31histone H4-K5 acetylation (GO:0043981)4.86557254
32histone H4-K8 acetylation (GO:0043982)4.86557254
33regulation of nuclear cell cycle DNA replication (GO:0033262)4.82144022
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.80890940
35histone H4-K12 acetylation (GO:0043983)4.72917181
36microtubule polymerization or depolymerization (GO:0031109)4.70111219
37protein localization to chromosome, centromeric region (GO:0071459)4.68431286
38muscle organ morphogenesis (GO:0048644)4.66036429
39sperm-egg recognition (GO:0035036)4.65187580
40calcium ion-dependent exocytosis (GO:0017156)4.60825557
41mitotic sister chromatid segregation (GO:0000070)4.60581141
42cellular ketone body metabolic process (GO:0046950)4.58579236
43heterochromatin organization (GO:0070828)4.54888542
44rRNA transcription (GO:0009303)4.49633567
45acrosome reaction (GO:0007340)4.49055657
46DNA replication-dependent nucleosome organization (GO:0034723)4.44567601
47DNA replication-dependent nucleosome assembly (GO:0006335)4.44567601
48nuclear pore complex assembly (GO:0051292)4.40494250
49negative regulation of telomerase activity (GO:0051974)4.39225557
50cilium organization (GO:0044782)4.36649037
51phosphatidylethanolamine biosynthetic process (GO:0006646)4.33985656
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.31134967
53cilium assembly (GO:0042384)4.30538986
54negative regulation of epidermal cell differentiation (GO:0045605)4.27906842
55establishment of protein localization to Golgi (GO:0072600)4.27503907
56protein targeting to Golgi (GO:0000042)4.26573156
57piRNA metabolic process (GO:0034587)4.26419649
58single fertilization (GO:0007338)4.25247830
59protein localization to cilium (GO:0061512)4.24476834
60spermatid development (GO:0007286)4.24152164
61regulation of MHC class I biosynthetic process (GO:0045343)4.21882250
62binding of sperm to zona pellucida (GO:0007339)4.20373316
63notochord development (GO:0030903)4.18155218
64phosphatidylethanolamine metabolic process (GO:0046337)4.17869899
65hormone catabolic process (GO:0042447)4.12846674
66cell-cell recognition (GO:0009988)4.10731439
67reproduction (GO:0000003)4.09137332
68ketone body metabolic process (GO:1902224)4.07122270
69cell wall macromolecule catabolic process (GO:0016998)4.04368100
70cell wall macromolecule metabolic process (GO:0044036)4.04368100
71left/right pattern formation (GO:0060972)4.04301403
72left/right axis specification (GO:0070986)4.04255660
73rRNA methylation (GO:0031167)3.99001771
74spermatogenesis (GO:0007283)3.93855607
75male gamete generation (GO:0048232)3.93299536
76retrograde transport, vesicle recycling within Golgi (GO:0000301)3.92446262
77spermatid nucleus differentiation (GO:0007289)3.90740588
78chromatin assembly (GO:0031497)3.87589020
79negative regulation of inclusion body assembly (GO:0090084)3.87460588
80centriole assembly (GO:0098534)3.87385335
81centriole replication (GO:0007099)3.87223139
82male meiosis (GO:0007140)3.80733785
83sister chromatid segregation (GO:0000819)3.77825155
84phenol-containing compound catabolic process (GO:0019336)3.74164869
85nuclear pore organization (GO:0006999)3.73889842
86* microtubule bundle formation (GO:0001578)3.72080777
87cytidine deamination (GO:0009972)3.71026221
88cytidine metabolic process (GO:0046087)3.71026221
89cytidine catabolic process (GO:0006216)3.71026221
90cell fate commitment involved in formation of primary germ layer (GO:0060795)3.68376438
91histone H4-K16 acetylation (GO:0043984)3.68263165
92rRNA modification (GO:0000154)3.65555448
93gamete generation (GO:0007276)3.63108823
94intraciliary transport (GO:0042073)3.62215472
95organic cation transport (GO:0015695)3.60364521
96fertilization (GO:0009566)3.58482022
97positive regulation of DNA-dependent DNA replication (GO:2000105)3.56745477
98response to dietary excess (GO:0002021)3.56181180
99negative regulation of telomere maintenance (GO:0032205)3.53998686
100negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.51567979
101pore complex assembly (GO:0046931)3.49577812
102chromosome condensation (GO:0030261)3.49322219
103synaptonemal complex organization (GO:0070193)3.45802345
104synaptonemal complex assembly (GO:0007130)3.45189746
105sexual reproduction (GO:0019953)3.42660983
106sensory perception of smell (GO:0007608)3.42562461
107cellular component assembly involved in morphogenesis (GO:0010927)3.39286950
108protein localization to Golgi apparatus (GO:0034067)3.38270446
109intestinal epithelial cell development (GO:0060576)3.37842148
110branching involved in mammary gland duct morphogenesis (GO:0060444)3.32245321
111* regulation of microtubule-based movement (GO:0060632)3.29897895
112interferon-gamma production (GO:0032609)3.29410280
113germ cell development (GO:0007281)3.26214589
114positive regulation of Rab GTPase activity (GO:0032851)3.25898156
115regulation of Rab GTPase activity (GO:0032313)3.25898156
116regulation of translation in response to stress (GO:0043555)3.24911382
117coenzyme catabolic process (GO:0009109)3.24649586
118DNA replication checkpoint (GO:0000076)3.24628109
119quinone metabolic process (GO:1901661)3.20351642
120maintenance of protein localization in organelle (GO:0072595)3.18703224
121nucleoside transmembrane transport (GO:1901642)3.17924738
122regulation of apoptotic process involved in morphogenesis (GO:1902337)3.16636601
123intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.14299246
124transepithelial transport (GO:0070633)3.14220315
125RNA stabilization (GO:0043489)3.13221754
126mRNA stabilization (GO:0048255)3.13221754
127primitive streak formation (GO:0090009)3.10126733
128cardiovascular system development (GO:0072358)3.08816628
129DNA packaging (GO:0006323)3.07617446
130nonmotile primary cilium assembly (GO:0035058)3.07310911
131* protein polyglutamylation (GO:0018095)3.07175444
132seminiferous tubule development (GO:0072520)3.06550496
133regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.05136364
134icosanoid secretion (GO:0032309)3.03983528
135arachidonic acid secretion (GO:0050482)3.03983528
136cilium morphogenesis (GO:0060271)2.97736881
137cellular process involved in reproduction in multicellular organism (GO:0022412)2.97141158
138microtubule-based movement (GO:0007018)2.93890881
139DNA methylation involved in gamete generation (GO:0043046)2.84967169
140multicellular organismal reproductive process (GO:0048609)2.84867516
141cell projection assembly (GO:0030031)2.83883088
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.82456008
143establishment of monopolar cell polarity (GO:0061162)2.82456008
144lateral ventricle development (GO:0021670)2.81235899
145chromatin silencing (GO:0006342)2.79006627
146spinal cord motor neuron differentiation (GO:0021522)2.77979336
147cell differentiation involved in metanephros development (GO:0072202)2.75403559
148brain morphogenesis (GO:0048854)2.75283236
149regulation of type B pancreatic cell apoptotic process (GO:2000674)2.73753594
150glomerular epithelial cell development (GO:0072310)2.73149194
151nephron epithelium morphogenesis (GO:0072088)2.72823529
152nephron tubule morphogenesis (GO:0072078)2.72823529
153urinary tract smooth muscle contraction (GO:0014848)2.70184745
154photoreceptor cell maintenance (GO:0045494)2.69667650
155ether metabolic process (GO:0018904)2.68321402
156regulation of inclusion body assembly (GO:0090083)2.66517217
157peristalsis (GO:0030432)2.63948515
158RNA destabilization (GO:0050779)2.62869858
159metanephric mesenchyme development (GO:0072075)2.61396493
160positive regulation of action potential (GO:0045760)2.57994888
161regulation of guanylate cyclase activity (GO:0031282)2.54494627
162regulation of transcription involved in cell fate commitment (GO:0060850)2.53915798
163cranial nerve morphogenesis (GO:0021602)2.53638634
164one-carbon compound transport (GO:0019755)2.49958211
165behavioral response to nicotine (GO:0035095)2.48122407
166determination of left/right symmetry (GO:0007368)2.47191017
167positive regulation of guanylate cyclase activity (GO:0031284)2.45708094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.22360717
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.22360717
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.22360717
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.29305416
5BP1_19119308_ChIP-ChIP_Hs578T_Human5.21797425
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.27743757
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.57655623
8EZH2_22144423_ChIP-Seq_EOC_Human3.33341764
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.11227413
10TP63_19390658_ChIP-ChIP_HaCaT_Human3.10307302
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.73122536
12E2F7_22180533_ChIP-Seq_HELA_Human2.68902922
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41039607
14TCF3_18692474_ChIP-Seq_MESCs_Mouse2.40913936
15* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.38411077
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.31816407
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29685471
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.24668054
19ZNF274_21170338_ChIP-Seq_K562_Hela2.20084019
20* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20016311
21DROSHA_22980978_ChIP-Seq_HELA_Human2.09598298
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08854401
23FUS_26573619_Chip-Seq_HEK293_Human2.07265259
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.06313460
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.02135044
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99067967
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97766050
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94890147
29* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.93695036
30TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90147005
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.90147005
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85571248
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84335788
34KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.81118707
35IRF1_19129219_ChIP-ChIP_H3396_Human1.78776162
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.76229054
37* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.74202092
38* CBP_20019798_ChIP-Seq_JUKART_Human1.74202092
39GBX2_23144817_ChIP-Seq_PC3_Human1.73981257
40P300_19829295_ChIP-Seq_ESCs_Human1.72858828
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72495887
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71880063
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71476289
44TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.71429774
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70943029
46POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70783638
47PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.70132014
48REST_21632747_ChIP-Seq_MESCs_Mouse1.67607928
49POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.62281151
50* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62167528
51* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61413504
52ER_23166858_ChIP-Seq_MCF-7_Human1.59458556
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.59171359
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56592763
55AR_25329375_ChIP-Seq_VCAP_Human1.54039830
56E2F1_17053090_ChIP-ChIP_MCF-7_Human1.53354802
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52912671
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52208806
59* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.51979700
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48335423
61SMAD4_21799915_ChIP-Seq_A2780_Human1.48277854
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.44968278
63NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44500896
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43414629
65ERA_21632823_ChIP-Seq_H3396_Human1.43291121
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.42776050
67ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40892130
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.40329964
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.39277820
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39026992
71SMAD3_21741376_ChIP-Seq_ESCs_Human1.38971056
72MYC_19829295_ChIP-Seq_ESCs_Human1.37196581
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.36572345
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36529541
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35208279
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.35204083
77* EZH2_27294783_Chip-Seq_ESCs_Mouse1.34326389
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.34208259
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.34099648
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34068342
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33404629
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.32720518
83AR_21572438_ChIP-Seq_LNCaP_Human1.32572973
84NANOG_20526341_ChIP-Seq_ESCs_Human1.32242455
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31434822
86TAF15_26573619_Chip-Seq_HEK293_Human1.30569784
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.30291669
88SOX2_18692474_ChIP-Seq_MESCs_Mouse1.29505134
89CTCF_27219007_Chip-Seq_Bcells_Human1.29343271
90STAT3_23295773_ChIP-Seq_U87_Human1.28684487
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27134238
92ELK4_26923725_Chip-Seq_MESODERM_Mouse1.26127297
93RNF2_27304074_Chip-Seq_NSC_Mouse1.26057273
94* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.24303606
95ETV1_20927104_ChIP-Seq_GIST48_Human1.24038768
96NANOG_16518401_ChIP-PET_MESCs_Mouse1.23929473
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23243999
98RUNX2_22187159_ChIP-Seq_PCA_Human1.22974589
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22574158
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21925549
101TAF2_19829295_ChIP-Seq_ESCs_Human1.21204474
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21094232
103NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20565613
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20522291
105RBPJ_21746931_ChIP-Seq_IB4_Human1.20132238
106TBL1_22424771_ChIP-Seq_293T_Human1.20120834
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.17989114
108CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17410977
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17357349
110RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17193208
111ERG_20517297_ChIP-Seq_VCAP_Human1.16356314
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.16245289
113NANOG_19829295_ChIP-Seq_ESCs_Human1.15553667
114SOX2_19829295_ChIP-Seq_ESCs_Human1.15553667
115FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15295471
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.15295471
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.15065167
118* STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14927933
119CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14776590
120* OCT4_20526341_ChIP-Seq_ESCs_Human1.14747297
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14727256
122PHF8_20622853_ChIP-Seq_HELA_Human1.14063637
123TCF4_23295773_ChIP-Seq_U87_Human1.13935409
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.13266027
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12770596
126SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12269823
127NFYB_21822215_ChIP-Seq_K562_Human1.11315410
128SALL1_21062744_ChIP-ChIP_HESCs_Human1.11176537
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10807942
130NANOG_21062744_ChIP-ChIP_HESCs_Human1.10648091
131NFYA_21822215_ChIP-Seq_K562_Human1.10259848
132NCOR_22424771_ChIP-Seq_293T_Human1.09169828
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.08828639
134IGF1R_20145208_ChIP-Seq_DFB_Human1.08703831
135TCF4_22108803_ChIP-Seq_LS180_Human1.07473556
136EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07437587
137POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06458094
138ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06401554
139CEBPB_22108803_ChIP-Seq_LS180_Human1.06327235
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06302836
141EZH2_27304074_Chip-Seq_ESCs_Mouse1.05835772
142REST_18959480_ChIP-ChIP_MESCs_Mouse1.05640228
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05457402
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05420527
145AUTS2_25519132_ChIP-Seq_293T-REX_Human1.05253826
146* HOXB7_26014856_ChIP-Seq_BT474_Human1.04929384
147PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04859238
148TP53_18474530_ChIP-ChIP_U2OS_Human1.04785524
149PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.04665581
150SMC4_20622854_ChIP-Seq_HELA_Human1.04111183
151VDR_22108803_ChIP-Seq_LS180_Human1.03687459
152SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03607964
153TP53_22127205_ChIP-Seq_IMR90_Human1.01608410
154RAC3_21632823_ChIP-Seq_H3396_Human1.00611931
155DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99596599
156MYC_19079543_ChIP-ChIP_MESCs_Mouse0.99228237
157ELF1_20517297_ChIP-Seq_JURKAT_Human0.97996880
158KAP1_27257070_Chip-Seq_ESCs_Mouse0.97017831
159* SPI1_26923725_Chip-Seq_HPCs_Mouse0.96513431
160POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96381353
161* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95819089
162MYC_19030024_ChIP-ChIP_MESCs_Mouse0.95343285
163SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93895245
164PHF8_20622854_ChIP-Seq_HELA_Human0.93404243
165CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91378352
166OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91234276
167CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90802068
168ZFP281_18757296_ChIP-ChIP_E14_Mouse0.90724133
169SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90080478
170TBX3_20139965_ChIP-Seq_ESCs_Mouse0.89993933
171BCOR_27268052_Chip-Seq_Bcells_Human0.89518860
172* ESET_19884257_ChIP-Seq_ESCs_Mouse0.89310885
173TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88269626
174CTCF_20526341_ChIP-Seq_ESCs_Human0.85232007
175MYC_18358816_ChIP-ChIP_MESCs_Mouse0.84333541
176NCOR1_26117541_ChIP-Seq_K562_Human0.84094803
177SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83727492
178FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82893163
179* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.82848974
180RXRA_24833708_ChIP-Seq_LIVER_Mouse0.82821373
181SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82277200
182CDX2_20551321_ChIP-Seq_CACO-2_Human0.81912192
183SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81907861
184TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.81111084
185KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79764521
186NANOG_16153702_ChIP-ChIP_HESCs_Human0.77808477
187ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.75701385
188GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75094735
189RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74693371
190GATA3_21867929_ChIP-Seq_CD8_Mouse0.74369652
191RARB_24833708_ChIP-Seq_LIVER_Mouse0.72019206
192MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.69709715
193MYC_18555785_ChIP-Seq_MESCs_Mouse0.69491812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.89533981
2MP0005394_taste/olfaction_phenotype4.04338670
3MP0005499_abnormal_olfactory_system4.04338670
4MP0003011_delayed_dark_adaptation3.90196079
5MP0002653_abnormal_ependyma_morphology3.89870700
6MP0004264_abnormal_extraembryonic_tissu3.78732755
7MP0002254_reproductive_system_inflammat3.63921874
8MP0005377_hearing/vestibular/ear_phenot3.58923772
9MP0003878_abnormal_ear_physiology3.58923772
10MP0006292_abnormal_olfactory_placode3.32411252
11MP0001984_abnormal_olfaction3.08873455
12MP0003890_abnormal_embryonic-extraembry3.01250312
13MP0008057_abnormal_DNA_replication2.90912086
14MP0004858_abnormal_nervous_system2.68612688
15MP0005075_abnormal_melanosome_morpholog2.60581326
16MP0008789_abnormal_olfactory_epithelium2.45632204
17MP0001485_abnormal_pinna_reflex2.39491116
18MP0003698_abnormal_male_reproductive2.31996246
19MP0004957_abnormal_blastocyst_morpholog2.31839021
20MP0002822_catalepsy2.22167189
21MP0002332_abnormal_exercise_endurance2.21661470
22MP0005670_abnormal_white_adipose2.15397669
23MP0005257_abnormal_intraocular_pressure2.08234058
24MP0001929_abnormal_gametogenesis2.06696723
25MP0006035_abnormal_mitochondrial_morpho2.00998781
26MP0003122_maternal_imprinting1.96335414
27MP0001293_anophthalmia1.92155722
28MP0003121_genomic_imprinting1.83107257
29MP0002876_abnormal_thyroid_physiology1.82964690
30MP0006276_abnormal_autonomic_nervous1.81131442
31MP0003705_abnormal_hypodermis_morpholog1.73073878
32MP0005551_abnormal_eye_electrophysiolog1.72345329
33MP0008875_abnormal_xenobiotic_pharmacok1.71014292
34MP0010352_gastrointestinal_tract_polyps1.66564726
35MP0001672_abnormal_embryogenesis/_devel1.65824925
36MP0005380_embryogenesis_phenotype1.65824925
37MP0001849_ear_inflammation1.62822130
38MP0003718_maternal_effect1.60564167
39MP0005379_endocrine/exocrine_gland_phen1.60346722
40MP0002735_abnormal_chemical_nociception1.60117356
41MP0003880_abnormal_central_pattern1.57408264
42MP0005623_abnormal_meninges_morphology1.54948182
43MP0003938_abnormal_ear_development1.53803450
44MP0001145_abnormal_male_reproductive1.53181177
45MP0002210_abnormal_sex_determination1.53117313
46MP0002088_abnormal_embryonic_growth/wei1.49373618
47MP0003984_embryonic_growth_retardation1.48359667
48MP0001765_abnormal_ion_homeostasis1.47956662
49MP0002557_abnormal_social/conspecific_i1.47731994
50MP0001486_abnormal_startle_reflex1.45560432
51MP0002092_abnormal_eye_morphology1.45025757
52MP0000678_abnormal_parathyroid_gland1.43205404
53MP0002277_abnormal_respiratory_mucosa1.40795006
54MP0005423_abnormal_somatic_nervous1.40595195
55MP0005645_abnormal_hypothalamus_physiol1.39511108
56MP0002127_abnormal_cardiovascular_syste1.37263388
57MP0002734_abnormal_mechanical_nocicepti1.36266436
58MP0002272_abnormal_nervous_system1.35447391
59MP0002909_abnormal_adrenal_gland1.35307838
60MP0001188_hyperpigmentation1.34404566
61MP0002233_abnormal_nose_morphology1.32227487
62MP0004133_heterotaxia1.29938225
63MP0002161_abnormal_fertility/fecundity1.29046848
64MP0002138_abnormal_hepatobiliary_system1.28185868
65MP0009745_abnormal_behavioral_response1.27852311
66MP0003183_abnormal_peptide_metabolism1.27301956
67MP0000350_abnormal_cell_proliferation1.26111456
68MP0001970_abnormal_pain_threshold1.25737583
69MP0001968_abnormal_touch/_nociception1.24994697
70MP0009046_muscle_twitch1.24878910
71MP0002160_abnormal_reproductive_system1.22559578
72MP0000026_abnormal_inner_ear1.22494458
73MP0002733_abnormal_thermal_nociception1.22452321
74MP0002572_abnormal_emotion/affect_behav1.22221570
75MP0002234_abnormal_pharynx_morphology1.20856532
76MP0004019_abnormal_vitamin_homeostasis1.20706841
77MP0003136_yellow_coat_color1.20543721
78MP0002132_abnormal_respiratory_system1.20318047
79MP0000955_abnormal_spinal_cord1.18391988
80MP0001905_abnormal_dopamine_level1.17674582
81MP0003077_abnormal_cell_cycle1.17556673
82MP0005253_abnormal_eye_physiology1.17137228
83MP0002085_abnormal_embryonic_tissue1.16486109
84MP0006082_CNS_inflammation1.16096823
85MP0003195_calcinosis1.15794795
86MP0002932_abnormal_joint_morphology1.15790419
87MP0008961_abnormal_basal_metabolism1.15304022
88MP0003111_abnormal_nucleus_morphology1.13915533
89MP0009379_abnormal_foot_pigmentation1.13518780
90MP0001963_abnormal_hearing_physiology1.13207319
91MP0010030_abnormal_orbit_morphology1.13150088
92MP0000049_abnormal_middle_ear1.13051170
93MP0002837_dystrophic_cardiac_calcinosis1.12619614
94MP0010094_abnormal_chromosome_stability1.10699708
95MP0002229_neurodegeneration1.09965322
96MP0002163_abnormal_gland_morphology1.09485180
97MP0002084_abnormal_developmental_patter1.09386742
98MP0003646_muscle_fatigue1.07454506
99MP0008877_abnormal_DNA_methylation1.07425320
100MP0005266_abnormal_metabolism1.07238602
101MP0000653_abnormal_sex_gland1.06786957
102MP0004742_abnormal_vestibular_system1.06506955
103MP0001529_abnormal_vocalization1.06087253
104MP0010386_abnormal_urinary_bladder1.05285034
105MP0002086_abnormal_extraembryonic_tissu1.05192258
106MP0000762_abnormal_tongue_morphology1.05157903
107MP0003879_abnormal_hair_cell1.04393791
108MP0004142_abnormal_muscle_tone1.03927437
109MP0005636_abnormal_mineral_homeostasis1.02912753
110MP0004043_abnormal_pH_regulation1.01223630
111MP0003787_abnormal_imprinting1.00473708
112MP0002184_abnormal_innervation0.99905073
113MP0000566_synostosis0.98106858
114MP0003693_abnormal_embryo_hatching0.97895432
115MP0004270_analgesia0.97597392
116MP0000432_abnormal_head_morphology0.97567307
117MP0002114_abnormal_axial_skeleton0.96961493
118MP0003315_abnormal_perineum_morphology0.96703795
119MP0003123_paternal_imprinting0.95355404
120MP0004885_abnormal_endolymph0.94963947
121MP0005391_vision/eye_phenotype0.94948119
122MP0002067_abnormal_sensory_capabilities0.92077426
123MP0001944_abnormal_pancreas_morphology0.91262896
124MP0002970_abnormal_white_adipose0.90747883
125MP0004859_abnormal_synaptic_plasticity0.90703399
126MP0000631_abnormal_neuroendocrine_gland0.89846991
127MP0002928_abnormal_bile_duct0.88226697
128MP0001730_embryonic_growth_arrest0.88110832
129MP0005248_abnormal_Harderian_gland0.88065186
130MP0002249_abnormal_larynx_morphology0.87767915
131MP0003119_abnormal_digestive_system0.86946816
132MP0005395_other_phenotype0.86219645
133MP0005646_abnormal_pituitary_gland0.85591373
134MP0008058_abnormal_DNA_repair0.85262982
135MP0002882_abnormal_neuron_morphology0.85019423
136MP0000313_abnormal_cell_death0.83507596
137MP0004085_abnormal_heartbeat0.83490140
138MP0003755_abnormal_palate_morphology0.83170484
139MP0003935_abnormal_craniofacial_develop0.82504509
140MP0005365_abnormal_bile_salt0.82006831
141MP0003635_abnormal_synaptic_transmissio0.81583455
142MP0000569_abnormal_digit_pigmentation0.80879489
143MP0004197_abnormal_fetal_growth/weight/0.79860283
144MP0002064_seizures0.79737350
145MP0002638_abnormal_pupillary_reflex0.79483088
146MP0003786_premature_aging0.78949332
147MP0002938_white_spotting0.78093067
148MP0002063_abnormal_learning/memory/cond0.77890781
149MP0002282_abnormal_trachea_morphology0.77239929
150MP0003861_abnormal_nervous_system0.75412326
151MP0000428_abnormal_craniofacial_morphol0.74895522
152MP0001697_abnormal_embryo_size0.74102654
153MP0008770_decreased_survivor_rate0.73334124
154MP0009703_decreased_birth_body0.73247350
155MP0000358_abnormal_cell_content/0.73112550
156MP0000490_abnormal_crypts_of0.72357354
157MP0003283_abnormal_digestive_organ0.71889064
158MP0008932_abnormal_embryonic_tissue0.71087095
159MP0001348_abnormal_lacrimal_gland0.70920465
160MP0008007_abnormal_cellular_replicative0.70653175
161MP0002080_prenatal_lethality0.69740546
162MP0002116_abnormal_craniofacial_bone0.68827900
163MP0003937_abnormal_limbs/digits/tail_de0.67333408
164MP0001286_abnormal_eye_development0.63284392
165MP0002752_abnormal_somatic_nervous0.63283126
166MP0004381_abnormal_hair_follicle0.63055603
167MP0003137_abnormal_impulse_conducting0.60550414
168MP0005389_reproductive_system_phenotype0.59926591
169MP0009115_abnormal_fat_cell0.58117121
170MP0002751_abnormal_autonomic_nervous0.57018003
171MP0002269_muscular_atrophy0.56596004
172MP0002925_abnormal_cardiovascular_devel0.55915214

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.81547556
2Bilateral microphthalmos (HP:0007633)6.41425773
3Hypochromic microcytic anemia (HP:0004840)5.32771770
4Abnormal respiratory motile cilium physiology (HP:0012261)5.31564220
5Absent/shortened dynein arms (HP:0200106)5.29836217
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.29836217
7Abnormality of the lower motor neuron (HP:0002366)4.94557169
8Abnormal ciliary motility (HP:0012262)4.51845749
9Nasal polyposis (HP:0100582)4.50415612
10Hepatoblastoma (HP:0002884)4.43166310
11Rhinitis (HP:0012384)4.41870254
12Tubulointerstitial nephritis (HP:0001970)4.21735078
13Severe visual impairment (HP:0001141)4.20120188
14Chronic bronchitis (HP:0004469)4.16558466
15Abnormal respiratory epithelium morphology (HP:0012253)4.09387874
16Abnormal respiratory motile cilium morphology (HP:0005938)4.09387874
17Multiple enchondromatosis (HP:0005701)4.02398626
18Nephronophthisis (HP:0000090)3.92497260
19Bifid tongue (HP:0010297)3.76635773
20Rib fusion (HP:0000902)3.74599514
21Pancreatic fibrosis (HP:0100732)3.73361592
22Chronic hepatic failure (HP:0100626)3.68090192
23Abnormality of the nasal mucosa (HP:0000433)3.63373459
24Abnormality of macular pigmentation (HP:0008002)3.61406555
25Nephroblastoma (Wilms tumor) (HP:0002667)3.60943424
26Ependymoma (HP:0002888)3.57522437
27Impulsivity (HP:0100710)3.54204198
28Abnormal rod and cone electroretinograms (HP:0008323)3.53356398
29Embryonal renal neoplasm (HP:0011794)3.33060420
30True hermaphroditism (HP:0010459)3.31901524
31Supernumerary spleens (HP:0009799)3.31215259
32Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29140552
33Pancreatic cysts (HP:0001737)3.26233090
34Abnormality of the renal medulla (HP:0100957)3.25190126
35Amyotrophic lateral sclerosis (HP:0007354)3.20770461
36Neoplasm of striated muscle (HP:0009728)3.15399293
37Male infertility (HP:0003251)3.09574770
38Hyperkalemia (HP:0002153)3.04473647
39Testicular atrophy (HP:0000029)2.91189639
40Bony spicule pigmentary retinopathy (HP:0007737)2.90343486
41Occipital encephalocele (HP:0002085)2.89027032
42Rhabdomyosarcoma (HP:0002859)2.88821558
43Short humerus (HP:0005792)2.83622163
44Aplasia/hypoplasia of the humerus (HP:0006507)2.83428915
45Decreased circulating renin level (HP:0003351)2.82125469
46Cystic liver disease (HP:0006706)2.74043932
47Molar tooth sign on MRI (HP:0002419)2.73641428
48Abnormality of midbrain morphology (HP:0002418)2.73641428
49Chromsome breakage (HP:0040012)2.73567321
50Facial cleft (HP:0002006)2.69411546
51Hyperactive renin-angiotensin system (HP:0000841)2.65793414
52Tubular atrophy (HP:0000092)2.65314159
53Hypoplasia of the fovea (HP:0007750)2.59912027
54Aplasia/Hypoplasia of the fovea (HP:0008060)2.59912027
55Abnormal lung lobation (HP:0002101)2.59761159
56Rectal fistula (HP:0100590)2.59705324
57Rectovaginal fistula (HP:0000143)2.59705324
58Abnormality of the phalanges of the hallux (HP:0010057)2.59678600
59Fused cervical vertebrae (HP:0002949)2.58438805
60Abnormality of the astrocytes (HP:0100707)2.51258428
61Astrocytoma (HP:0009592)2.51258428
62Partial duplication of thumb phalanx (HP:0009944)2.50712971
63Attenuation of retinal blood vessels (HP:0007843)2.42986936
64Meckel diverticulum (HP:0002245)2.40198053
65Bronchiectasis (HP:0002110)2.39442378
66Abnormal biliary tract physiology (HP:0012439)2.38906775
67Bile duct proliferation (HP:0001408)2.38906775
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.34951646
69Polydipsia (HP:0001959)2.32731829
70Abnormal drinking behavior (HP:0030082)2.32731829
71Hyperinsulinemic hypoglycemia (HP:0000825)2.32364323
72Anencephaly (HP:0002323)2.31431339
73Abnormality of the salivary glands (HP:0010286)2.29633537
74Horizontal nystagmus (HP:0000666)2.29168637
75Trismus (HP:0000211)2.27406057
76Intestinal fistula (HP:0100819)2.26561870
77Medial flaring of the eyebrow (HP:0010747)2.25998273
78Tubulointerstitial abnormality (HP:0001969)2.25893109
79Abnormality of the ileum (HP:0001549)2.25511885
80Infertility (HP:0000789)2.25121906
81Sensory axonal neuropathy (HP:0003390)2.25097330
82Postaxial foot polydactyly (HP:0001830)2.24689057
83Vaginal fistula (HP:0004320)2.23522002
84Tongue fasciculations (HP:0001308)2.22641330
85Congenital stationary night blindness (HP:0007642)2.21336274
86Bronchitis (HP:0012387)2.21034067
87Anomalous pulmonary venous return (HP:0010772)2.20818473
88Sclerocornea (HP:0000647)2.20196143
89Azoospermia (HP:0000027)2.18852428
90Facial shape deformation (HP:0011334)2.15127104
91Potter facies (HP:0002009)2.15127104
92Median cleft lip (HP:0000161)2.14445941
93Preauricular pit (HP:0004467)2.14357228
94Periauricular skin pits (HP:0100277)2.14357228
95Congenital hepatic fibrosis (HP:0002612)2.14104341
96Pendular nystagmus (HP:0012043)2.14058076
97Dyschromatopsia (HP:0007641)2.13700591
98Partial duplication of the phalanx of hand (HP:0009999)2.13090950
99Ragged-red muscle fibers (HP:0003200)2.12346779
100Hypochromic anemia (HP:0001931)2.11057382
101Abnormality of the fovea (HP:0000493)2.10233741
102Spastic tetraparesis (HP:0001285)2.09810316
103Abnormality of chloride homeostasis (HP:0011422)2.09113431
104Upper motor neuron abnormality (HP:0002127)2.06515433
105Stage 5 chronic kidney disease (HP:0003774)2.05073527
106Neoplasm of the heart (HP:0100544)2.04584122
107Chronic sinusitis (HP:0011109)2.04144216
108Bell-shaped thorax (HP:0001591)2.03601851
109Hyperaldosteronism (HP:0000859)2.03104918
110Cone-rod dystrophy (HP:0000548)2.03101488
111Hypopigmentation of the fundus (HP:0007894)2.02326232
112Genital tract atresia (HP:0001827)2.02149534
113Abnormality of renin-angiotensin system (HP:0000847)2.02086682
114Aplasia/Hypoplasia of the sternum (HP:0006714)2.01290731
115Abnormal cartilage morphology (HP:0002763)2.01280000
116Polyuria (HP:0000103)2.00356370
117Difficulty running (HP:0009046)1.99827085
118Gait imbalance (HP:0002141)1.99812218
119Abnormality of potassium homeostasis (HP:0011042)1.98660275
120Muscle fibrillation (HP:0010546)1.98642918
121Renal dysplasia (HP:0000110)1.98587127
122Congenital primary aphakia (HP:0007707)1.98212729
123Double outlet right ventricle (HP:0001719)1.97695125
124Congenital malformation of the right heart (HP:0011723)1.97695125
125Vaginal atresia (HP:0000148)1.96972379
126Abnormal urine output (HP:0012590)1.96077687
127Preauricular skin tag (HP:0000384)1.95162418
128Tetraplegia (HP:0002445)1.94622733
129Villous atrophy (HP:0011473)1.93682953
130Abnormality of small intestinal villus morphology (HP:0011472)1.93682953
131Abnormality of renal excretion (HP:0011036)1.93587914
132Hyperventilation (HP:0002883)1.93389751
133Abnormality of the renal cortex (HP:0011035)1.93314215
134Reduced antithrombin III activity (HP:0001976)1.92869373
135Male pseudohermaphroditism (HP:0000037)1.92620156
136Duodenal stenosis (HP:0100867)1.92470458
137Small intestinal stenosis (HP:0012848)1.92470458
138Progressive muscle weakness (HP:0003323)1.91734329
139Aplasia/Hypoplasia of the macula (HP:0008059)1.90650668
140Abnormality of the distal phalanx of the thumb (HP:0009617)1.89653838
141Shawl scrotum (HP:0000049)1.88889882
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88684050
143Malnutrition (HP:0004395)1.87796401
144Sloping forehead (HP:0000340)1.87716109
145Abnormality of the pulmonary veins (HP:0011718)1.86038861
146Abnormality of the pubic bones (HP:0003172)1.85648785
147Glioma (HP:0009733)1.84822355
148Embryonal neoplasm (HP:0002898)1.84714303
149Progressive external ophthalmoplegia (HP:0000590)1.84690911
150Generalized hypotonia (HP:0001290)1.84083656
151Recurrent sinusitis (HP:0011108)1.83900653
152Atrophy/Degeneration involving motor neurons (HP:0007373)1.83585642
153Large earlobe (HP:0009748)1.83328380
154Nephrogenic diabetes insipidus (HP:0009806)1.82173061
155Decreased central vision (HP:0007663)1.78528661
156Progressive cerebellar ataxia (HP:0002073)1.72321927
157Intestinal atresia (HP:0011100)1.71909478
158Postaxial hand polydactyly (HP:0001162)1.70873992
159Recurrent otitis media (HP:0000403)1.70105566
160Preaxial hand polydactyly (HP:0001177)1.69672939
161Hyponatremia (HP:0002902)1.68217417
162Abnormality of the aortic arch (HP:0012303)1.66638710
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.63455060
164Myokymia (HP:0002411)1.61983562
165Poor coordination (HP:0002370)1.61468133
166Abnormal spermatogenesis (HP:0008669)1.61371596
167Hypokalemia (HP:0002900)1.59598384
168Glycosuria (HP:0003076)1.59083354
169Abnormality of urine glucose concentration (HP:0011016)1.59083354
170Aplasia/Hypoplasia of the tongue (HP:0010295)1.58507898
171Optic nerve hypoplasia (HP:0000609)1.57690571
172Hypoplastic ischia (HP:0003175)1.57168165
173Abnormal pancreas size (HP:0012094)1.53712917
174Renal salt wasting (HP:0000127)1.46411957
175Anophthalmia (HP:0000528)1.45997105
176Gastrointestinal atresia (HP:0002589)1.45844728
177Osteomalacia (HP:0002749)1.44918602
178Generalized aminoaciduria (HP:0002909)1.44565556
179Amelogenesis imperfecta (HP:0000705)1.41948978
180Atelectasis (HP:0100750)1.41457255

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.72098263
2GRK54.94424074
3GRK63.82531897
4ERN13.64075060
5INSRR3.30992304
6GRK13.13892547
7PDK33.03582247
8PDK43.03582247
9TTK2.90992155
10FRK2.81381746
11ADRBK22.76964268
12TYRO32.70437775
13CASK2.54542079
14CSF1R2.46524360
15MAP4K22.45931676
16TGFBR22.38154232
17WNK12.27189806
18GRK72.13714785
19MAPK72.13460698
20TNIK2.09635559
21LMTK22.00829055
22PDK21.99245759
23STK101.93513065
24BRD41.92894995
25ICK1.92005764
26PLK21.86319695
27NTRK31.86169402
28MATK1.85173521
29WNK31.76805868
30CAMK1G1.71430041
31MOS1.68639194
32DDR21.67835512
33TESK11.66828840
34MST41.60037536
35PRKD31.59604398
36SIK21.47383263
37MAP3K41.47169387
38EPHA21.44989163
39CHEK21.44078415
40OXSR11.41900214
41PRKG21.38043766
42CDK71.37859887
43AKT31.31782800
44NEK21.31361957
45MARK21.28936857
46MAP3K91.28849849
47BMPR1B1.25801398
48ACVR1B1.23207716
49PLK11.20664603
50CAMK41.18154987
51NTRK11.12926547
52PAK41.07690339
53MKNK21.06113336
54MST1R1.02411761
55STK381.02310015
56BCR1.01862245
57MAP2K40.98339584
58PINK10.93013617
59CHEK10.90905946
60MAP2K60.88782076
61ZAK0.83456305
62RPS6KA20.83349658
63ADRBK10.81973551
64DYRK30.81455135
65HIPK20.80808333
66WEE10.78078495
67PRKCE0.76119433
68NME10.75789088
69DAPK20.73682281
70MAP3K100.72628721
71FGFR30.72084024
72MAP2K70.71639815
73PRKAA20.71189302
74CDC70.70944136
75AKT20.68949773
76PASK0.68470698
77PHKG20.68034692
78PHKG10.68034692
79ARAF0.67313870
80PDPK10.67126358
81PRKG10.66720055
82FGFR20.64584964
83DYRK1B0.64504189
84MTOR0.63002302
85MAP3K20.62727844
86SGK4940.62302969
87SGK2230.62302969
88TLK10.61134312
89CAMK1D0.59915876
90PNCK0.59586443
91PRKCZ0.59550895
92CSK0.58971085
93MAP2K20.58158438
94MUSK0.57038814
95PRKCI0.56412215
96BRAF0.55629259
97MINK10.55578799
98MARK10.54682426
99ALK0.54225978
100AURKA0.51002927
101STK110.50902078
102STK38L0.49575172
103NEK60.49388049
104TAF10.48852485
105CAMK10.48820492
106PAK10.48663926
107LATS20.46877523
108STK390.45790136
109ROCK10.45047803
110CDK20.44731551
111ATM0.44657967
112MET0.44639499
113EPHA40.44055071
114RPS6KA60.43907651
115SRPK10.43735074
116PRKCQ0.43395538
117EIF2AK20.43349294
118NUAK10.41708143
119MAPK150.41584011
120WNK40.41425618
121PRKCG0.38832413
122MAPKAPK30.38605223
123BUB10.38184955
124MAPK130.38176952
125CAMK2A0.38012476
126TAOK30.37533853
127SGK10.37087748
128TIE10.36201851
129STK30.35920432
130MAPK120.35642053
131MAP3K70.34556464
132MKNK10.33383143
133MAPK80.33303766
134CSNK1E0.32428490
135NTRK20.32179057
136PRKCH0.31940827
137CDK40.31848504
138CSNK1A10.31832818
139PRKAA10.31620180
140PRKCA0.31559716
141RPS6KA10.30968126
142AURKB0.30661615
143MAPK100.29878754
144PTK2B0.28385788
145CDK10.24996372
146IGF1R0.24349138
147PDK10.23876306
148GSK3B0.23351428
149ERBB20.22843304
150PRKCD0.22019676
151PAK30.20691361
152PTK20.20397014
153RPS6KB20.18725644
154RIPK10.18530828
155DYRK20.17268121
156DYRK1A0.17171168
157INSR0.15623250
158PRKACG0.14912498
159MAPK140.14186588
160PRKD20.13695954
161MAPK10.13178002
162PRKACB0.12859250
163ATR0.11700154
164CDK150.10319008
165PRKACA0.08669147
166CDK11A0.08269253
167PLK40.08191913
168NEK10.08007470
169PAK20.07938842

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.36736929
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.11113181
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.67798788
4Fructose and mannose metabolism_Homo sapiens_hsa000513.85391330
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.59806204
6Arachidonic acid metabolism_Homo sapiens_hsa005902.91718531
7Linoleic acid metabolism_Homo sapiens_hsa005912.83731496
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76416827
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.65310050
10Butanoate metabolism_Homo sapiens_hsa006502.42433989
11Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.34069269
12Phototransduction_Homo sapiens_hsa047442.33313626
13Fanconi anemia pathway_Homo sapiens_hsa034602.11873322
14Olfactory transduction_Homo sapiens_hsa047402.10881347
15RNA transport_Homo sapiens_hsa030132.07065077
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.05061778
17Galactose metabolism_Homo sapiens_hsa000522.03778239
18Phenylalanine metabolism_Homo sapiens_hsa003601.98137308
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93667840
20Histidine metabolism_Homo sapiens_hsa003401.88765412
21mRNA surveillance pathway_Homo sapiens_hsa030151.85791392
22Fatty acid degradation_Homo sapiens_hsa000711.75055549
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.74102797
24ABC transporters_Homo sapiens_hsa020101.68896459
25Retinol metabolism_Homo sapiens_hsa008301.66177710
26Nitrogen metabolism_Homo sapiens_hsa009101.62794686
27Basal transcription factors_Homo sapiens_hsa030221.62655368
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62113601
29Insulin secretion_Homo sapiens_hsa049111.56436508
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56389404
31beta-Alanine metabolism_Homo sapiens_hsa004101.53767268
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51628652
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50135604
34Oxidative phosphorylation_Homo sapiens_hsa001901.47935970
35Fatty acid metabolism_Homo sapiens_hsa012121.44855537
36Nicotine addiction_Homo sapiens_hsa050331.43597139
37Tyrosine metabolism_Homo sapiens_hsa003501.36221966
38Pentose phosphate pathway_Homo sapiens_hsa000301.34280246
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33345190
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.30700633
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29751282
42Ether lipid metabolism_Homo sapiens_hsa005651.29123663
43Tryptophan metabolism_Homo sapiens_hsa003801.27585011
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26728220
45Caffeine metabolism_Homo sapiens_hsa002321.26137759
46mTOR signaling pathway_Homo sapiens_hsa041501.25615871
47Peroxisome_Homo sapiens_hsa041461.25300374
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17596814
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17105687
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.15595504
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14304794
52Serotonergic synapse_Homo sapiens_hsa047261.11204625
53Cell cycle_Homo sapiens_hsa041101.09934698
54Inositol phosphate metabolism_Homo sapiens_hsa005621.04466130
55Hedgehog signaling pathway_Homo sapiens_hsa043401.03883541
56Fat digestion and absorption_Homo sapiens_hsa049751.03358531
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01687365
58Morphine addiction_Homo sapiens_hsa050321.00163178
59Ovarian steroidogenesis_Homo sapiens_hsa049130.99581667
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99093146
61Fatty acid biosynthesis_Homo sapiens_hsa000610.99034571
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98777668
63Chemical carcinogenesis_Homo sapiens_hsa052040.98200387
64Parkinsons disease_Homo sapiens_hsa050120.95228682
65Arginine and proline metabolism_Homo sapiens_hsa003300.94760128
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.93566222
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.93323631
68Other glycan degradation_Homo sapiens_hsa005110.90219679
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90213490
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89404870
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89280738
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89096514
73RNA degradation_Homo sapiens_hsa030180.88680937
74Propanoate metabolism_Homo sapiens_hsa006400.88199035
75Homologous recombination_Homo sapiens_hsa034400.87753577
76Taste transduction_Homo sapiens_hsa047420.86698487
77Thyroid cancer_Homo sapiens_hsa052160.85534753
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84051969
79Salivary secretion_Homo sapiens_hsa049700.83302680
80Circadian entrainment_Homo sapiens_hsa047130.79364426
81Vitamin digestion and absorption_Homo sapiens_hsa049770.79113444
82GABAergic synapse_Homo sapiens_hsa047270.78675557
83Dorso-ventral axis formation_Homo sapiens_hsa043200.78040199
84Collecting duct acid secretion_Homo sapiens_hsa049660.76803483
85Oocyte meiosis_Homo sapiens_hsa041140.76199912
86Glycerolipid metabolism_Homo sapiens_hsa005610.76168605
87Basal cell carcinoma_Homo sapiens_hsa052170.74686790
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73995386
89Synaptic vesicle cycle_Homo sapiens_hsa047210.73733782
90Alzheimers disease_Homo sapiens_hsa050100.72568889
91Cocaine addiction_Homo sapiens_hsa050300.71638018
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70435304
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69156090
94Spliceosome_Homo sapiens_hsa030400.67501660
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.67276039
96Starch and sucrose metabolism_Homo sapiens_hsa005000.67170750
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66988003
98DNA replication_Homo sapiens_hsa030300.65361947
99Regulation of autophagy_Homo sapiens_hsa041400.64794061
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.63864248
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63170911
102Carbon metabolism_Homo sapiens_hsa012000.62964700
103Pancreatic secretion_Homo sapiens_hsa049720.62650214
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62387015
105Type II diabetes mellitus_Homo sapiens_hsa049300.61012059
106Sphingolipid metabolism_Homo sapiens_hsa006000.60925618
107Arginine biosynthesis_Homo sapiens_hsa002200.56884089
108p53 signaling pathway_Homo sapiens_hsa041150.56693264
109AMPK signaling pathway_Homo sapiens_hsa041520.55948809
110Selenocompound metabolism_Homo sapiens_hsa004500.55335666
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53734361
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53033436
113Pyruvate metabolism_Homo sapiens_hsa006200.52966306
114Purine metabolism_Homo sapiens_hsa002300.50138533
115Renin secretion_Homo sapiens_hsa049240.48501847
116Mismatch repair_Homo sapiens_hsa034300.48326362
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47831054
118Base excision repair_Homo sapiens_hsa034100.47423667
119Pathways in cancer_Homo sapiens_hsa052000.47073364
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46846340
121Circadian rhythm_Homo sapiens_hsa047100.46785371
122Glucagon signaling pathway_Homo sapiens_hsa049220.45417704
123Tight junction_Homo sapiens_hsa045300.44835330
124Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44779286
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.44436503
126Gastric acid secretion_Homo sapiens_hsa049710.43769017
127Hippo signaling pathway_Homo sapiens_hsa043900.40803789
128Choline metabolism in cancer_Homo sapiens_hsa052310.40204507
129Dopaminergic synapse_Homo sapiens_hsa047280.40002501
130Rap1 signaling pathway_Homo sapiens_hsa040150.39801539
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39649073
132cAMP signaling pathway_Homo sapiens_hsa040240.39593660
133Sulfur relay system_Homo sapiens_hsa041220.38862322
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.38828093
135Cholinergic synapse_Homo sapiens_hsa047250.38625128
136Axon guidance_Homo sapiens_hsa043600.38602840
137Notch signaling pathway_Homo sapiens_hsa043300.38341937
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37412181
139Wnt signaling pathway_Homo sapiens_hsa043100.36836056
140PPAR signaling pathway_Homo sapiens_hsa033200.35627666
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34555604
142Acute myeloid leukemia_Homo sapiens_hsa052210.34130135
143Pyrimidine metabolism_Homo sapiens_hsa002400.33655696
144Renin-angiotensin system_Homo sapiens_hsa046140.31301944
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30952174
146MicroRNAs in cancer_Homo sapiens_hsa052060.29936584
147Bile secretion_Homo sapiens_hsa049760.28268735
148Biosynthesis of amino acids_Homo sapiens_hsa012300.28140639
149Calcium signaling pathway_Homo sapiens_hsa040200.27702133
150Metabolic pathways_Homo sapiens_hsa011000.27677226
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.27432903
152Viral carcinogenesis_Homo sapiens_hsa052030.25665424
153RNA polymerase_Homo sapiens_hsa030200.25605701
154VEGF signaling pathway_Homo sapiens_hsa043700.24872151
155Protein digestion and absorption_Homo sapiens_hsa049740.24555566
156Mineral absorption_Homo sapiens_hsa049780.23693746
157One carbon pool by folate_Homo sapiens_hsa006700.22559675
158Huntingtons disease_Homo sapiens_hsa050160.22436510
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.22281703
160Cardiac muscle contraction_Homo sapiens_hsa042600.20314542
161Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20245369
162Non-homologous end-joining_Homo sapiens_hsa034500.20121793
163Glutathione metabolism_Homo sapiens_hsa004800.19990257
164Glutamatergic synapse_Homo sapiens_hsa047240.19624477

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