TTLL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.11923057
2axon ensheathment in central nervous system (GO:0032291)6.11923057
3neuronal action potential propagation (GO:0019227)5.01196886
4synaptic vesicle maturation (GO:0016188)4.50138219
5postsynaptic membrane organization (GO:0001941)4.36510622
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30383918
7synaptic vesicle exocytosis (GO:0016079)4.19631854
8neuron cell-cell adhesion (GO:0007158)4.14259507
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.13248927
10regulation of synaptic vesicle exocytosis (GO:2000300)4.12130523
11glutamate secretion (GO:0014047)4.02757921
12auditory behavior (GO:0031223)3.78812850
13neurotransmitter-gated ion channel clustering (GO:0072578)3.78640492
14myelination (GO:0042552)3.68887246
15axon ensheathment (GO:0008366)3.68552142
16ensheathment of neurons (GO:0007272)3.68552142
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67416501
18locomotory exploration behavior (GO:0035641)3.54938464
19presynaptic membrane organization (GO:0097090)3.53103727
20long-chain fatty acid biosynthetic process (GO:0042759)3.51573588
21regulation of synaptic vesicle transport (GO:1902803)3.50187639
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.46028793
23protein localization to synapse (GO:0035418)3.44636690
24negative regulation of neurotransmitter transport (GO:0051589)3.44555524
25adult walking behavior (GO:0007628)3.43383883
26startle response (GO:0001964)3.43289751
27transmission of nerve impulse (GO:0019226)3.42909225
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42804617
29presynaptic membrane assembly (GO:0097105)3.41371885
30establishment of mitochondrion localization (GO:0051654)3.39441612
31positive regulation of synapse maturation (GO:0090129)3.36284347
32negative regulation of neurotransmitter secretion (GO:0046929)3.34326191
33vocalization behavior (GO:0071625)3.33994490
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.33426891
35pyrimidine nucleobase catabolic process (GO:0006208)3.28045863
36serotonin metabolic process (GO:0042428)3.25440188
37fatty acid elongation (GO:0030497)3.25097397
38gamma-aminobutyric acid transport (GO:0015812)3.23273634
39positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21993881
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.21035745
41cellular potassium ion homeostasis (GO:0030007)3.20283805
42regulation of neuronal synaptic plasticity (GO:0048168)3.19815669
43neuronal ion channel clustering (GO:0045161)3.16047887
44neuron-neuron synaptic transmission (GO:0007270)3.15445095
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14960963
46regulation of neurotransmitter levels (GO:0001505)3.12363563
47neuromuscular synaptic transmission (GO:0007274)3.11936332
48neurotransmitter secretion (GO:0007269)3.11227142
49mating behavior (GO:0007617)3.10968533
50mechanosensory behavior (GO:0007638)3.10245652
51synaptic transmission, glutamatergic (GO:0035249)3.09870815
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09678295
53L-amino acid import (GO:0043092)3.06327767
54membrane depolarization during action potential (GO:0086010)3.05934717
55neuronal action potential (GO:0019228)3.05300796
56glutamate receptor signaling pathway (GO:0007215)3.05178425
57response to auditory stimulus (GO:0010996)3.04335657
58regulation of synaptic transmission, glutamatergic (GO:0051966)3.03991634
59positive regulation of dendritic spine development (GO:0060999)3.03668519
60potassium ion homeostasis (GO:0055075)3.02073074
61neuron recognition (GO:0008038)3.01178039
62gamma-aminobutyric acid signaling pathway (GO:0007214)2.99683768
63glycine transport (GO:0015816)2.99332035
64neuromuscular process controlling posture (GO:0050884)2.99217353
65detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.97125371
66detection of temperature stimulus involved in sensory perception (GO:0050961)2.97125371
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.97031126
68proline transport (GO:0015824)2.96460389
69primary amino compound metabolic process (GO:1901160)2.95876444
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.95450948
71layer formation in cerebral cortex (GO:0021819)2.94313200
72regulation of voltage-gated calcium channel activity (GO:1901385)2.94197358
73synapse assembly (GO:0007416)2.94016230
74regulation of long-term neuronal synaptic plasticity (GO:0048169)2.92699878
75cerebellar Purkinje cell differentiation (GO:0021702)2.90667901
76nucleobase catabolic process (GO:0046113)2.90568206
77negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89345219
78regulation of glutamate receptor signaling pathway (GO:1900449)2.87659290
79regulation of synapse structural plasticity (GO:0051823)2.87501813
80positive regulation of potassium ion transport (GO:0043268)2.86540479
81neurotransmitter uptake (GO:0001504)2.86231126
82regulation of synapse maturation (GO:0090128)2.86019735
83apical protein localization (GO:0045176)2.85926497
84nerve growth factor signaling pathway (GO:0038180)2.85178800
85vesicle transport along microtubule (GO:0047496)2.84700560
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.84421724
87organelle transport along microtubule (GO:0072384)2.84333168
88cell differentiation in hindbrain (GO:0021533)2.84316479
89cell migration in hindbrain (GO:0021535)2.84187050
90synaptic transmission (GO:0007268)2.84116989
91dendritic spine morphogenesis (GO:0060997)2.83797032
92dendrite morphogenesis (GO:0048813)2.83727679
93neurotransmitter transport (GO:0006836)2.83569726
94detection of calcium ion (GO:0005513)2.83409172
95neurofilament cytoskeleton organization (GO:0060052)2.81878071
96regulation of neurotransmitter secretion (GO:0046928)2.81743031
97positive regulation of dendritic spine morphogenesis (GO:0061003)2.80914609
98regulation of dendritic spine development (GO:0060998)2.80223605
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.78494839
100behavioral defense response (GO:0002209)2.77287161
101behavioral fear response (GO:0001662)2.77287161
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75709583
103positive regulation of membrane potential (GO:0045838)2.74271534
104cellular sodium ion homeostasis (GO:0006883)2.74051822
105membrane hyperpolarization (GO:0060081)2.73856726
106positive regulation of synapse assembly (GO:0051965)2.73213034
107exploration behavior (GO:0035640)2.72906470
108neuromuscular process controlling balance (GO:0050885)2.71637373
109regulation of neurotransmitter uptake (GO:0051580)2.71485154
110adult behavior (GO:0030534)2.71204241
111myelin maintenance (GO:0043217)2.71130572
112detection of temperature stimulus (GO:0016048)2.71000365
113membrane depolarization (GO:0051899)2.68729407
114regulation of vesicle fusion (GO:0031338)2.67340948
115synaptic vesicle docking involved in exocytosis (GO:0016081)2.67226151
116activation of protein kinase A activity (GO:0034199)2.66968566
117potassium ion import (GO:0010107)2.66783739
118axonal fasciculation (GO:0007413)2.66489374
119regulation of synaptic plasticity (GO:0048167)2.66477277
120calcium ion-dependent exocytosis (GO:0017156)2.66258022
121regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.65861389
122cerebellar granule cell differentiation (GO:0021707)2.65757221
123regulation of dendritic spine morphogenesis (GO:0061001)2.65335407
124regulation of neurotransmitter transport (GO:0051588)2.65156262
125regulation of postsynaptic membrane potential (GO:0060078)2.64270809
126long-term memory (GO:0007616)2.63849013
127negative regulation of axonogenesis (GO:0050771)2.63090393
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.62431718
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62406142
130negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.62137670
131behavioral response to cocaine (GO:0048148)2.60075553
132sodium ion export (GO:0071436)2.57855460
133axon cargo transport (GO:0008088)2.57210812
134negative regulation of protein localization to cell surface (GO:2000009)2.56393135
135synaptic vesicle endocytosis (GO:0048488)2.55809254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63513293
2GBX2_23144817_ChIP-Seq_PC3_Human3.58295241
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.91619003
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82114339
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.76651678
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52969022
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52969022
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42556866
9SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39557894
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38388421
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37673233
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33858492
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.27002988
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.22200993
15REST_21632747_ChIP-Seq_MESCs_Mouse2.21189996
16DROSHA_22980978_ChIP-Seq_HELA_Human2.15872975
17* TAF15_26573619_Chip-Seq_HEK293_Human2.12950063
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11686335
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11631749
20RARB_27405468_Chip-Seq_BRAIN_Mouse2.11244661
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.11218469
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.96463994
23REST_18959480_ChIP-ChIP_MESCs_Mouse1.81738177
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79862497
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71977251
26AR_21572438_ChIP-Seq_LNCaP_Human1.70452217
27OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61689213
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60472141
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58895891
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57872352
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56915217
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.53998217
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51138127
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46552460
35CDX2_19796622_ChIP-Seq_MESCs_Mouse1.46414699
36VDR_22108803_ChIP-Seq_LS180_Human1.40581620
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40097042
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39690145
39P300_19829295_ChIP-Seq_ESCs_Human1.38773998
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37629696
41* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35336747
42* SMAD3_21741376_ChIP-Seq_EPCs_Human1.34835637
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34672315
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32781493
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32140660
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32018495
47STAT3_23295773_ChIP-Seq_U87_Human1.30656556
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.28929126
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25540073
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.25272718
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25127706
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23885698
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.23570865
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23514815
55* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20157450
56* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20157450
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19385193
58ER_23166858_ChIP-Seq_MCF-7_Human1.17569605
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17367349
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16781143
61TP53_16413492_ChIP-PET_HCT116_Human1.15694413
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15385168
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14934446
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14794260
65* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14747814
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14415799
67ZNF274_21170338_ChIP-Seq_K562_Hela1.13164173
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12947166
69* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12195771
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11683784
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.11204515
72* TCF4_23295773_ChIP-Seq_U87_Human1.09932752
73* AHR_22903824_ChIP-Seq_MCF-7_Human1.08820877
74CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08533905
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.08407589
76EWS_26573619_Chip-Seq_HEK293_Human1.08016075
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07172360
78BCAT_22108803_ChIP-Seq_LS180_Human1.06702136
79* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05514780
80* P53_22387025_ChIP-Seq_ESCs_Mouse1.05108362
81* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04658280
82AR_25329375_ChIP-Seq_VCAP_Human1.04614475
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04152357
84CBP_20019798_ChIP-Seq_JUKART_Human1.04152357
85* RNF2_27304074_Chip-Seq_NSC_Mouse1.03911398
86* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03348654
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03341432
88* SOX9_26525672_Chip-Seq_HEART_Mouse1.00074917
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99928501
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99735105
91* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98397149
92IGF1R_20145208_ChIP-Seq_DFB_Human0.97657218
93TAL1_26923725_Chip-Seq_HPCs_Mouse0.97642015
94* PRDM14_20953172_ChIP-Seq_ESCs_Human0.97549664
95AR_19668381_ChIP-Seq_PC3_Human0.97414577
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97366500
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97356332
98JUN_21703547_ChIP-Seq_K562_Human0.97064284
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96208496
100RUNX2_22187159_ChIP-Seq_PCA_Human0.95523211
101RING1B_27294783_Chip-Seq_NPCs_Mouse0.95245019
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.94909688
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.92868406
104NANOG_18555785_Chip-Seq_ESCs_Mouse0.92691024
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92189043
106* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91096050
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.90313907
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.89169767
109* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88913599
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88792119
111FUS_26573619_Chip-Seq_HEK293_Human0.87206472
112* SMAD3_21741376_ChIP-Seq_ESCs_Human0.86559344
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86248385
114KDM2B_26808549_Chip-Seq_REH_Human0.85545187
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84495457
116NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83501864
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83501864

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.70412589
2MP0003880_abnormal_central_pattern4.69742394
3MP0004270_analgesia4.40777804
4MP0003635_abnormal_synaptic_transmissio3.29233747
5MP0001968_abnormal_touch/_nociception3.04201364
6MP0002734_abnormal_mechanical_nocicepti2.95079555
7MP0002272_abnormal_nervous_system2.94693725
8MP0009046_muscle_twitch2.91297662
9MP0002064_seizures2.89386076
10MP0002735_abnormal_chemical_nociception2.81336951
11MP0009745_abnormal_behavioral_response2.79851935
12MP0000920_abnormal_myelination2.71486412
13MP0001486_abnormal_startle_reflex2.55304499
14MP0000569_abnormal_digit_pigmentation2.53625852
15MP0002063_abnormal_learning/memory/cond2.50206044
16MP0002736_abnormal_nociception_after2.46453921
17MP0005423_abnormal_somatic_nervous2.45329698
18MP0003329_amyloid_beta_deposits2.36364013
19MP0003787_abnormal_imprinting2.35080620
20MP0002733_abnormal_thermal_nociception2.28079925
21MP0002572_abnormal_emotion/affect_behav2.23975219
22MP0001970_abnormal_pain_threshold2.22606098
23MP0002822_catalepsy2.11301808
24MP0002067_abnormal_sensory_capabilities1.96741531
25MP0001984_abnormal_olfaction1.88634627
26MP0001440_abnormal_grooming_behavior1.83626894
27MP0000778_abnormal_nervous_system1.83590702
28MP0001529_abnormal_vocalization1.79224326
29MP0004885_abnormal_endolymph1.78817598
30MP0006276_abnormal_autonomic_nervous1.78093021
31MP0008569_lethality_at_weaning1.76915970
32MP0001501_abnormal_sleep_pattern1.75746352
33MP0004142_abnormal_muscle_tone1.73744264
34MP0002184_abnormal_innervation1.72361247
35MP0000955_abnormal_spinal_cord1.71792128
36MP0001905_abnormal_dopamine_level1.71554779
37MP0004742_abnormal_vestibular_system1.59112474
38MP0004145_abnormal_muscle_electrophysio1.58447554
39MP0002229_neurodegeneration1.57487346
40MP0003634_abnormal_glial_cell1.56518321
41MP0004924_abnormal_behavior1.56510439
42MP0005386_behavior/neurological_phenoty1.56510439
43MP0003690_abnormal_glial_cell1.56339150
44MP0004858_abnormal_nervous_system1.56322362
45MP0002882_abnormal_neuron_morphology1.53098002
46MP0004811_abnormal_neuron_physiology1.45376411
47MP0002066_abnormal_motor_capabilities/c1.43173682
48MP0003633_abnormal_nervous_system1.41955424
49MP0001485_abnormal_pinna_reflex1.38579189
50MP0002557_abnormal_social/conspecific_i1.34164371
51MP0009780_abnormal_chondrocyte_physiolo1.31093197
52MP0003631_nervous_system_phenotype1.30347134
53MP0008877_abnormal_DNA_methylation1.26965204
54MP0005646_abnormal_pituitary_gland1.25141457
55MP0004043_abnormal_pH_regulation1.23486136
56MP0002638_abnormal_pupillary_reflex1.23182264
57MP0005409_darkened_coat_color1.21332510
58MP0005410_abnormal_fertilization1.21074045
59MP0002909_abnormal_adrenal_gland1.20018078
60MP0005645_abnormal_hypothalamus_physiol1.18955437
61MP0003632_abnormal_nervous_system1.15840926
62MP0005551_abnormal_eye_electrophysiolog1.14896924
63MP0001986_abnormal_taste_sensitivity1.13873615
64MP0005171_absent_coat_pigmentation1.12916226
65MP0001299_abnormal_eye_distance/1.12467971
66MP0003121_genomic_imprinting1.09279389
67MP0000604_amyloidosis1.06791981
68MP0000747_muscle_weakness1.05604870
69MP0003123_paternal_imprinting1.05073712
70MP0002752_abnormal_somatic_nervous1.04950363
71MP0000751_myopathy1.04203381
72MP0003183_abnormal_peptide_metabolism1.01723861
73MP0001963_abnormal_hearing_physiology0.99782978
74MP0000013_abnormal_adipose_tissue0.98887184
75MP0001502_abnormal_circadian_rhythm0.98855035
76MP0005253_abnormal_eye_physiology0.98005147
77MP0002152_abnormal_brain_morphology0.94891308
78MP0003879_abnormal_hair_cell0.90969818
79MP0004133_heterotaxia0.90489804
80MP0008260_abnormal_autophagy0.83637438
81MP0001188_hyperpigmentation0.81425823
82MP0004085_abnormal_heartbeat0.80617712
83MP0008874_decreased_physiological_sensi0.80074622
84MP0004147_increased_porphyrin_level0.79635168
85MP0003950_abnormal_plasma_membrane0.78828961
86MP0000026_abnormal_inner_ear0.77793785
87MP0005187_abnormal_penis_morphology0.77639160
88MP0001348_abnormal_lacrimal_gland0.76614354
89MP0005623_abnormal_meninges_morphology0.76383303
90MP0004036_abnormal_muscle_relaxation0.75341078
91MP0002837_dystrophic_cardiac_calcinosis0.74783199
92MP0004215_abnormal_myocardial_fiber0.74741518
93MP0001177_atelectasis0.74367469
94MP0002102_abnormal_ear_morphology0.72525685
95MP0000749_muscle_degeneration0.72224081
96MP0002069_abnormal_eating/drinking_beha0.71104273
97MP0003861_abnormal_nervous_system0.71089455
98MP0000566_synostosis0.70473028
99MP0003137_abnormal_impulse_conducting0.70357382
100MP0003136_yellow_coat_color0.69562393
101MP0002234_abnormal_pharynx_morphology0.68905845
102MP0001664_abnormal_digestion0.65548322
103MP0005195_abnormal_posterior_eye0.64993632
104MP0000427_abnormal_hair_cycle0.63814596
105MP0003890_abnormal_embryonic-extraembry0.63364228
106MP0005535_abnormal_body_temperature0.63113405
107MP0004130_abnormal_muscle_cell0.62923347
108MP0002653_abnormal_ependyma_morphology0.62659091
109MP0010386_abnormal_urinary_bladder0.62584539
110MP0002876_abnormal_thyroid_physiology0.62022089
111MP0000631_abnormal_neuroendocrine_gland0.61678325
112MP0008872_abnormal_physiological_respon0.61138721
113MP0001943_abnormal_respiration0.58835024
114MP0005379_endocrine/exocrine_gland_phen0.57838481
115MP0002090_abnormal_vision0.57795834
116MP0010770_preweaning_lethality0.57190839
117MP0002082_postnatal_lethality0.57190839
118MP0010769_abnormal_survival0.56807432
119MP0002751_abnormal_autonomic_nervous0.56614492
120MP0003122_maternal_imprinting0.54724097
121MP0000462_abnormal_digestive_system0.54313749
122MP0003283_abnormal_digestive_organ0.53845515
123MP0006072_abnormal_retinal_apoptosis0.52008632
124MP0005394_taste/olfaction_phenotype0.51263670

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.37891651
2Focal motor seizures (HP:0011153)5.46315943
3Neurofibrillary tangles (HP:0002185)4.50746372
4Supranuclear gaze palsy (HP:0000605)4.29992165
5Focal seizures (HP:0007359)4.25581859
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.18195460
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.18195460
8Atonic seizures (HP:0010819)4.14393186
9Action tremor (HP:0002345)4.02209761
10Abnormality of the corticospinal tract (HP:0002492)3.81626126
11Ankle clonus (HP:0011448)3.79422079
12Termporal pattern (HP:0011008)3.78822418
13Insidious onset (HP:0003587)3.78822418
14Pheochromocytoma (HP:0002666)3.56494021
15Cerebral inclusion bodies (HP:0100314)3.56258892
16Peripheral hypomyelination (HP:0007182)3.52222769
17Spastic gait (HP:0002064)3.50727305
18Epileptic encephalopathy (HP:0200134)3.46724203
19Dysmetria (HP:0001310)3.41362495
20Progressive cerebellar ataxia (HP:0002073)3.30530211
21Visual hallucinations (HP:0002367)3.29131310
22Sensory axonal neuropathy (HP:0003390)3.22122734
23Drooling (HP:0002307)3.19718134
24Scanning speech (HP:0002168)3.18941136
25Febrile seizures (HP:0002373)3.15771783
26Onion bulb formation (HP:0003383)3.15537070
27Neuroendocrine neoplasm (HP:0100634)3.14419275
28Absence seizures (HP:0002121)3.07866667
29Dialeptic seizures (HP:0011146)3.02029535
30Excessive salivation (HP:0003781)2.89880326
31Intention tremor (HP:0002080)2.89506091
32Generalized tonic-clonic seizures (HP:0002069)2.88250479
33Diplopia (HP:0000651)2.86056151
34Abnormality of binocular vision (HP:0011514)2.86056151
35Gaze-evoked nystagmus (HP:0000640)2.75426055
36Truncal ataxia (HP:0002078)2.72209489
37Retinal dysplasia (HP:0007973)2.71927739
38Ulnar claw (HP:0001178)2.70936233
39Absent speech (HP:0001344)2.69854376
40Hypsarrhythmia (HP:0002521)2.67859735
41Urinary urgency (HP:0000012)2.61989695
42Lower limb muscle weakness (HP:0007340)2.57556893
43Urinary bladder sphincter dysfunction (HP:0002839)2.55014630
44Limb dystonia (HP:0002451)2.49228302
45Protruding tongue (HP:0010808)2.49129605
46Broad-based gait (HP:0002136)2.47547404
47Dysdiadochokinesis (HP:0002075)2.47425856
48Genetic anticipation (HP:0003743)2.46984609
49Polyphagia (HP:0002591)2.45786392
50Anxiety (HP:0000739)2.43872814
51Megalencephaly (HP:0001355)2.42072343
52Status epilepticus (HP:0002133)2.41239602
53Impaired vibration sensation in the lower limbs (HP:0002166)2.39857926
54Progressive inability to walk (HP:0002505)2.38685055
55Foot dorsiflexor weakness (HP:0009027)2.38054227
56Depression (HP:0000716)2.28755135
57Segmental peripheral demyelination/remyelination (HP:0003481)2.27279556
58Hammertoe (HP:0001765)2.27184027
59Molar tooth sign on MRI (HP:0002419)2.25115237
60Abnormality of midbrain morphology (HP:0002418)2.25115237
61Akinesia (HP:0002304)2.22929618
62Medial flaring of the eyebrow (HP:0010747)2.22042785
63Postural instability (HP:0002172)2.14547499
64Clonus (HP:0002169)2.13523425
65Cerebral hemorrhage (HP:0001342)2.13290289
66Pancreatic fibrosis (HP:0100732)2.13183363
67Hemiplegia (HP:0002301)2.12882810
68Abnormality of the foot musculature (HP:0001436)2.12638103
69Nephronophthisis (HP:0000090)2.12084247
70Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.11998184
71Slow saccadic eye movements (HP:0000514)2.06698178
72Decreased motor nerve conduction velocity (HP:0003431)2.06500628
73Steppage gait (HP:0003376)2.06157276
74Hyperventilation (HP:0002883)2.05500282
75Impaired smooth pursuit (HP:0007772)2.05489577
76Abnormal eating behavior (HP:0100738)2.04714090
77Torticollis (HP:0000473)2.03232276
78Thickened helices (HP:0000391)2.03119818
79Sleep apnea (HP:0010535)2.02907154
80Alacrima (HP:0000522)2.01333761
81Cerebral hypomyelination (HP:0006808)1.99543220
82Hemiparesis (HP:0001269)1.98279155
83Inability to walk (HP:0002540)1.97850250
84True hermaphroditism (HP:0010459)1.97742096
85Distal sensory impairment (HP:0002936)1.97461802
86Neuronal loss in central nervous system (HP:0002529)1.97222737
87Congenital primary aphakia (HP:0007707)1.95202474
88Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.94740246
89Prolonged QT interval (HP:0001657)1.94590156
90Spastic tetraplegia (HP:0002510)1.93556690
91Papilledema (HP:0001085)1.93047700
92Amblyopia (HP:0000646)1.92974109
93Hyporeflexia of lower limbs (HP:0002600)1.92964029
94Aplasia involving bones of the extremities (HP:0009825)1.92535754
95Aplasia involving bones of the upper limbs (HP:0009823)1.92535754
96Aplasia of the phalanges of the hand (HP:0009802)1.92535754
97Abnormal auditory evoked potentials (HP:0006958)1.91662273
98Poor eye contact (HP:0000817)1.91064572
99Pancreatic cysts (HP:0001737)1.90809961
100Genital tract atresia (HP:0001827)1.90463660
101Mutism (HP:0002300)1.88102912
102Vaginal atresia (HP:0000148)1.87980859
103Agitation (HP:0000713)1.85656986
104Fetal akinesia sequence (HP:0001989)1.85206787
105Postural tremor (HP:0002174)1.85103618
106Rapidly progressive (HP:0003678)1.85085985
107Type II lissencephaly (HP:0007260)1.84773661
108Neoplasm of the peripheral nervous system (HP:0100007)1.84693583
109Generalized myoclonic seizures (HP:0002123)1.84466631
110Specific learning disability (HP:0001328)1.83538617
111Parakeratosis (HP:0001036)1.81075884
112Focal dystonia (HP:0004373)1.79966919
113Abnormality of ocular smooth pursuit (HP:0000617)1.78261799
114Impaired vibratory sensation (HP:0002495)1.77893073
115Abnormality of saccadic eye movements (HP:0000570)1.77883267
116Increased circulating renin level (HP:0000848)1.76879809
117Autoamputation (HP:0001218)1.76676883
118Rigidity (HP:0002063)1.76131697
119Epileptiform EEG discharges (HP:0011182)1.74840617
120Abnormality of the renal medulla (HP:0100957)1.74817835
121Nephrogenic diabetes insipidus (HP:0009806)1.74558295
122Abnormal social behavior (HP:0012433)1.73013569
123Impaired social interactions (HP:0000735)1.73013569
124Morphological abnormality of the pyramidal tract (HP:0002062)1.72644883
125Slow progression (HP:0003677)1.72167403
126EEG with generalized epileptiform discharges (HP:0011198)1.72006270
127Gait ataxia (HP:0002066)1.71977220
128Congenital stationary night blindness (HP:0007642)1.71230694
129Craniofacial dystonia (HP:0012179)1.70994953
130Bundle branch block (HP:0011710)1.69668429
131Spastic tetraparesis (HP:0001285)1.68660002
132Lissencephaly (HP:0001339)1.68659720
133Bradykinesia (HP:0002067)1.68116254
134Gait imbalance (HP:0002141)1.68104815
135Polydipsia (HP:0001959)1.67733944
136Abnormal drinking behavior (HP:0030082)1.67733944
137Hypoplasia of the corpus callosum (HP:0002079)1.67715133
138Paraplegia (HP:0010550)1.67683146
139Incomplete penetrance (HP:0003829)1.65559979
140Abnormality of salivation (HP:0100755)1.63726948
141Syncope (HP:0001279)1.61300192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.78869193
2NTRK33.11168602
3OXSR12.91548127
4EPHA42.89901396
5MAP3K92.86548176
6NTRK12.81065366
7FRK2.48944227
8PAK62.18288227
9KSR22.08696380
10CDK192.05555037
11MINK11.99753595
12MAP3K41.95317592
13PNCK1.87689313
14WNK11.84408079
15MARK11.84090556
16ARAF1.77635580
17CASK1.77500539
18WNK41.74849211
19LIMK11.70187436
20UHMK11.63811506
21MAP2K71.62378493
22MAPKAPK51.61256386
23DAPK21.60118516
24PHKG11.57532204
25PHKG21.57532204
26BCR1.50871194
27TNIK1.46761786
28CDK51.46575970
29CAMK2B1.45237668
30WNK31.40217724
31PRKD31.38175661
32SGK4941.34141279
33SGK2231.34141279
34MAP3K21.33635822
35CAMK2D1.30969773
36GRK51.30685243
37PRPF4B1.29751801
38PKN11.28986542
39FGFR21.21895260
40MAP2K41.20210132
41NTRK21.17837956
42EPHB11.17287652
43SGK21.17114204
44CSNK1G21.16635395
45RIPK41.11658825
46CAMK2A1.08102939
47NEK61.06951188
48SIK21.05889470
49CSNK1G31.05536236
50CDK141.04669035
51CAMKK21.03002888
52CAMK2G1.02445549
53MAP4K21.00917482
54ROCK21.00684557
55PAK31.00548500
56CSNK1A1L0.99311811
57MAP3K130.97965440
58LMTK20.97962744
59RET0.97134321
60MAPK130.97038726
61BMPR1B0.96969631
62CAMKK10.96043141
63DYRK20.95157074
64CDK150.92539562
65PINK10.91712883
66CDK180.91448995
67ADRBK20.89645522
68MET0.89300361
69MAP3K120.87422840
70PRKCG0.84889844
71TYRO30.83133231
72PDPK10.80723337
73CDK11A0.80623789
74ICK0.80234660
75FGR0.79069179
76PRKCH0.77220201
77PLK20.75034577
78PTK2B0.74772651
79MARK20.74534763
80PRKCE0.70000696
81CSNK1G10.69716598
82STK110.68733064
83MAP3K10.68706202
84INSRR0.68323373
85SGK30.66221390
86CAMK40.65544908
87FES0.65181880
88DAPK10.63823497
89KSR10.63653338
90PDK10.62307617
91PRKCZ0.62272409
92AKT30.61192950
93GRK10.60570285
94CCNB10.59108793
95MUSK0.55273746
96CAMK1G0.53679612
97FYN0.51716986
98CAMK10.51291282
99BMPR20.48872973
100LATS20.48816497
101PRKD10.46771614
102PRKCQ0.46373376
103ERBB20.46313370
104FER0.46117319
105MAPK100.46062389
106CSNK1D0.45523779
107SGK10.44772030
108CSNK1E0.43758373
109NME10.42900147
110RAF10.41975174
111DMPK0.41928820
112STK380.41540435
113DYRK1A0.41469841
114TRIM280.41295560
115PRKG10.41029914
116CSNK1A10.39946845
117ROCK10.39921002
118ERBB30.39799652
119PIK3CA0.39522930
120PRKCA0.37832049
121MAP2K10.37675612
122PRKACA0.37595923
123TNK20.37013175
124PRKCB0.36411995
125PRKACB0.35761246
126STK38L0.35672904
127RPS6KA30.35478910
128ADRBK10.34484841

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.90295493
2Olfactory transduction_Homo sapiens_hsa047402.70909987
3Nicotine addiction_Homo sapiens_hsa050332.64697913
4GABAergic synapse_Homo sapiens_hsa047272.47218966
5Glutamatergic synapse_Homo sapiens_hsa047242.33018936
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31029498
7Circadian entrainment_Homo sapiens_hsa047132.26347726
8Morphine addiction_Homo sapiens_hsa050322.23248846
9Long-term potentiation_Homo sapiens_hsa047202.03978573
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00245548
11Salivary secretion_Homo sapiens_hsa049701.94447313
12Dopaminergic synapse_Homo sapiens_hsa047281.93410359
13Amphetamine addiction_Homo sapiens_hsa050311.91688887
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.88946457
15Insulin secretion_Homo sapiens_hsa049111.86442689
16Taste transduction_Homo sapiens_hsa047421.85956136
17Serotonergic synapse_Homo sapiens_hsa047261.78765127
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76997219
19Cholinergic synapse_Homo sapiens_hsa047251.71603218
20Gastric acid secretion_Homo sapiens_hsa049711.68774157
21Collecting duct acid secretion_Homo sapiens_hsa049661.63920135
22Long-term depression_Homo sapiens_hsa047301.61308542
23Cocaine addiction_Homo sapiens_hsa050301.50714639
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.50024736
25Renin secretion_Homo sapiens_hsa049241.42768002
26Axon guidance_Homo sapiens_hsa043601.35792832
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34351253
28Oxytocin signaling pathway_Homo sapiens_hsa049211.31761824
29Cardiac muscle contraction_Homo sapiens_hsa042601.31090978
30Vibrio cholerae infection_Homo sapiens_hsa051101.31069659
31Calcium signaling pathway_Homo sapiens_hsa040201.29684962
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28286194
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22919902
34Ether lipid metabolism_Homo sapiens_hsa005651.21406819
35Gap junction_Homo sapiens_hsa045401.21273409
36Fatty acid elongation_Homo sapiens_hsa000621.16779106
37Oxidative phosphorylation_Homo sapiens_hsa001901.15287283
38GnRH signaling pathway_Homo sapiens_hsa049121.14410954
39Dorso-ventral axis formation_Homo sapiens_hsa043201.14290400
40cAMP signaling pathway_Homo sapiens_hsa040241.12959074
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.09011102
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07574389
43Steroid biosynthesis_Homo sapiens_hsa001001.06599975
44Nitrogen metabolism_Homo sapiens_hsa009101.05835237
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05360609
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04732444
47Pancreatic secretion_Homo sapiens_hsa049721.04710848
48Phototransduction_Homo sapiens_hsa047441.04046176
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02700683
50Alzheimers disease_Homo sapiens_hsa050101.01841934
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01479817
52ErbB signaling pathway_Homo sapiens_hsa040120.96764063
53Histidine metabolism_Homo sapiens_hsa003400.93732241
54Parkinsons disease_Homo sapiens_hsa050120.92270646
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.90327474
56Circadian rhythm_Homo sapiens_hsa047100.89755030
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89396081
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88158829
59Estrogen signaling pathway_Homo sapiens_hsa049150.87528424
60SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87474267
61Type II diabetes mellitus_Homo sapiens_hsa049300.85212361
62Melanogenesis_Homo sapiens_hsa049160.84483373
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84238849
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83855453
65beta-Alanine metabolism_Homo sapiens_hsa004100.83334516
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79785265
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.76111739
68Endocytosis_Homo sapiens_hsa041440.75652325
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75586044
70Thyroid hormone synthesis_Homo sapiens_hsa049180.75118962
71Ras signaling pathway_Homo sapiens_hsa040140.71387256
72Renal cell carcinoma_Homo sapiens_hsa052110.70250075
73Glioma_Homo sapiens_hsa052140.66551506
74MAPK signaling pathway_Homo sapiens_hsa040100.63890210
75Dilated cardiomyopathy_Homo sapiens_hsa054140.63548942
76Sphingolipid metabolism_Homo sapiens_hsa006000.62642872
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.62038893
78Choline metabolism in cancer_Homo sapiens_hsa052310.61298024
79Oocyte meiosis_Homo sapiens_hsa041140.59021339
80ABC transporters_Homo sapiens_hsa020100.58829301
81Tight junction_Homo sapiens_hsa045300.54848531
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.54596813
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54200496
84Ovarian steroidogenesis_Homo sapiens_hsa049130.53611806
85Hippo signaling pathway_Homo sapiens_hsa043900.52929713
86Inositol phosphate metabolism_Homo sapiens_hsa005620.52579598
87Sulfur metabolism_Homo sapiens_hsa009200.51141357
88Linoleic acid metabolism_Homo sapiens_hsa005910.50808789
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50273632
90Alcoholism_Homo sapiens_hsa050340.49201263
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47574118
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46368814
93Glucagon signaling pathway_Homo sapiens_hsa049220.46122452
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45651547
95Rap1 signaling pathway_Homo sapiens_hsa040150.45311202
96Regulation of autophagy_Homo sapiens_hsa041400.44993743
97Mineral absorption_Homo sapiens_hsa049780.44848660
98Fatty acid biosynthesis_Homo sapiens_hsa000610.43738740
99Bile secretion_Homo sapiens_hsa049760.43716765
100Butanoate metabolism_Homo sapiens_hsa006500.43655205
101VEGF signaling pathway_Homo sapiens_hsa043700.43554173
102Prion diseases_Homo sapiens_hsa050200.43272337
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43185587
104Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42632632
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42377150
106Rheumatoid arthritis_Homo sapiens_hsa053230.41698553
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40936602
108Arginine and proline metabolism_Homo sapiens_hsa003300.40284290
109Huntingtons disease_Homo sapiens_hsa050160.40171382
110Wnt signaling pathway_Homo sapiens_hsa043100.40018258
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38522136
112Vitamin B6 metabolism_Homo sapiens_hsa007500.36315048
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34552668
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.34342176
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.33672430
116Hedgehog signaling pathway_Homo sapiens_hsa043400.33010802
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26082218
118Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25204602

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