TTLL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.84838055
2binding of sperm to zona pellucida (GO:0007339)9.84796998
3cell-cell recognition (GO:0009988)9.76601800
4regulation of cilium movement (GO:0003352)9.54629076
5spermatid development (GO:0007286)9.45568965
6response to pheromone (GO:0019236)9.09409729
7reproduction (GO:0000003)9.07722060
8cilium movement (GO:0003341)9.05880634
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.43127862
10piRNA metabolic process (GO:0034587)7.80623248
11single fertilization (GO:0007338)7.40184500
12sperm capacitation (GO:0048240)7.39454930
13male meiosis (GO:0007140)7.28915498
14rRNA methylation (GO:0031167)7.19955071
15synaptonemal complex organization (GO:0070193)7.14080676
16negative regulation of inclusion body assembly (GO:0090084)6.81356818
17synaptonemal complex assembly (GO:0007130)6.70422638
18phosphatidylethanolamine biosynthetic process (GO:0006646)6.64402256
19organic cation transport (GO:0015695)6.39743831
20fertilization (GO:0009566)6.31333412
21spermatogenesis (GO:0007283)6.27763136
22male gamete generation (GO:0048232)6.25416614
23protein targeting to Golgi (GO:0000042)6.18461375
24phosphatidylethanolamine metabolic process (GO:0046337)6.15621700
25rRNA modification (GO:0000154)6.06881599
26cellular ketone body metabolic process (GO:0046950)5.98976434
27establishment of protein localization to Golgi (GO:0072600)5.94858225
28microtubule depolymerization (GO:0007019)5.94589032
29retrograde transport, vesicle recycling within Golgi (GO:0000301)5.88617496
30ventricular system development (GO:0021591)5.87443809
31regulation of microtubule-based movement (GO:0060632)5.80268093
32gamete generation (GO:0007276)5.73854182
33regulation of inclusion body assembly (GO:0090083)5.65832497
34calcium ion-dependent exocytosis (GO:0017156)5.61371501
35male meiosis I (GO:0007141)5.46810616
36centriole replication (GO:0007099)5.33603460
37germ cell development (GO:0007281)5.31049139
38regulation of Rab GTPase activity (GO:0032313)5.30467723
39positive regulation of Rab GTPase activity (GO:0032851)5.30467723
40ketone body metabolic process (GO:1902224)5.27954842
41cellular process involved in reproduction in multicellular organism (GO:0022412)5.23957187
42microtubule severing (GO:0051013)5.06068732
43DNA methylation involved in gamete generation (GO:0043046)4.88832990
44left/right pattern formation (GO:0060972)4.76040359
45cell recognition (GO:0008037)4.72997315
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.70277598
47regulation of transcription involved in cell fate commitment (GO:0060850)4.60772407
48chromatin silencing (GO:0006342)4.55695348
49multicellular organismal reproductive process (GO:0048609)4.53978402
50chromosome organization involved in meiosis (GO:0070192)4.49537152
51peptidyl-threonine dephosphorylation (GO:0035970)4.48916402
52protein localization to Golgi apparatus (GO:0034067)4.45366262
53seminiferous tubule development (GO:0072520)4.44558231
54meiosis I (GO:0007127)4.34279312
55meiotic nuclear division (GO:0007126)4.26364204
56glycerol ether metabolic process (GO:0006662)4.19463479
57protein localization to cilium (GO:0061512)4.05894547
58coenzyme catabolic process (GO:0009109)3.94476328
59genitalia morphogenesis (GO:0035112)3.90765657
60ether metabolic process (GO:0018904)3.86952620
61negative regulation of Rho protein signal transduction (GO:0035024)3.84531925
62chromosome condensation (GO:0030261)3.81936772
63spermatid nucleus differentiation (GO:0007289)3.78964024
64protein polyglutamylation (GO:0018095)3.77756488
65DNA packaging (GO:0006323)3.77721478
66chaperone-mediated protein complex assembly (GO:0051131)3.72800517
67multicellular organismal movement (GO:0050879)3.72247954
68musculoskeletal movement (GO:0050881)3.72247954
69multicellular organismal development (GO:0007275)3.67077418
70nucleosome disassembly (GO:0006337)3.66313653
71protein-DNA complex disassembly (GO:0032986)3.66313653
72axoneme assembly (GO:0035082)3.60088149
73meiotic cell cycle (GO:0051321)3.58185779
74amino-acid betaine transport (GO:0015838)3.47740837
75carnitine transport (GO:0015879)3.47740837
76polyamine biosynthetic process (GO:0006596)3.40356954
77homeostasis of number of cells within a tissue (GO:0048873)3.36793066
78carnitine transmembrane transport (GO:1902603)3.34528845
79response to acidic pH (GO:0010447)3.32845192
80cerebral cortex neuron differentiation (GO:0021895)3.31771889
81intraciliary transport (GO:0042073)3.24266846
82protein refolding (GO:0042026)3.21700258
83cellular response to pH (GO:0071467)3.21257242
84Golgi to endosome transport (GO:0006895)3.20626587
85microtubule-based movement (GO:0007018)3.19262764
86regulation of interleukin-13 production (GO:0032656)3.15704907
87cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.15419540
88nucleoside diphosphate phosphorylation (GO:0006165)3.14636962
89negative regulation of gene expression, epigenetic (GO:0045814)3.09200521
90membrane protein intracellular domain proteolysis (GO:0031293)3.09141040
91regulation of T-helper 2 cell differentiation (GO:0045628)3.07620376
92monoubiquitinated protein deubiquitination (GO:0035520)3.04531182
93protein depolymerization (GO:0051261)3.04074840
94cilium morphogenesis (GO:0060271)3.00956424
95* cilium organization (GO:0044782)3.00413568
96alditol metabolic process (GO:0019400)2.99006568
97glycolytic process (GO:0006096)2.97087278
98polyol catabolic process (GO:0046174)2.96725446
99DNA conformation change (GO:0071103)2.96598508
100single strand break repair (GO:0000012)2.95364605
101NAD biosynthetic process (GO:0009435)2.93614380
102microtubule nucleation (GO:0007020)2.92828632
103microtubule polymerization or depolymerization (GO:0031109)2.92538808
104sexual reproduction (GO:0019953)2.89950617
105negative regulation of organelle assembly (GO:1902116)2.89903703
106RNA localization (GO:0006403)2.88327543
107negative regulation of histone methylation (GO:0031061)2.87164383
108* cilium assembly (GO:0042384)2.86503446
109positive regulation of guanylate cyclase activity (GO:0031284)2.85909889
110glomerular visceral epithelial cell development (GO:0072015)2.85585362
111histone H3-K9 demethylation (GO:0033169)2.85311948
112regulation of spindle checkpoint (GO:0090231)2.84279886
113mitotic G1 DNA damage checkpoint (GO:0031571)2.83517755
114lactate metabolic process (GO:0006089)2.81638867
115peptidyl-glutamic acid modification (GO:0018200)2.81202017
116mitochondrial fission (GO:0000266)2.80288099
117mesenchymal cell differentiation involved in renal system development (GO:2001012)2.79621984
118mesenchymal cell differentiation involved in kidney development (GO:0072161)2.79621984
119mitotic sister chromatid cohesion (GO:0007064)2.79104672
120GTP biosynthetic process (GO:0006183)2.78999887
121gene silencing by RNA (GO:0031047)2.78952474
122glomerular epithelial cell development (GO:0072310)2.78233492
123negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75302998
124nucleus organization (GO:0006997)2.75108060
125meiotic cell cycle process (GO:1903046)2.74170492
126* cellular component assembly involved in morphogenesis (GO:0010927)2.73101525
127RNA destabilization (GO:0050779)2.70766149
128regulation of meiosis I (GO:0060631)2.61250767
129protein K11-linked deubiquitination (GO:0035871)2.57502885
130regulation of cilium assembly (GO:1902017)2.57450241
131centriole assembly (GO:0098534)2.53783645
132synapsis (GO:0007129)2.52439999
133regulation of protein kinase C signaling (GO:0090036)2.50580680
134quaternary ammonium group transport (GO:0015697)2.47255443
135regulation of centriole replication (GO:0046599)2.46932240
136glycerol metabolic process (GO:0006071)2.45482303
137UTP biosynthetic process (GO:0006228)2.45163643
138sperm motility (GO:0030317)13.4353728
139fusion of sperm to egg plasma membrane (GO:0007342)13.3803890
140acrosome reaction (GO:0007340)12.2123675
141cilium or flagellum-dependent cell motility (GO:0001539)11.9717439
142axonemal dynein complex assembly (GO:0070286)11.0419774
143sperm-egg recognition (GO:0035036)10.9398321
144multicellular organism reproduction (GO:0032504)10.8422818
145cell wall macromolecule metabolic process (GO:0044036)10.4743331
146cell wall macromolecule catabolic process (GO:0016998)10.4743331
147epithelial cilium movement (GO:0003351)10.4466268
148plasma membrane fusion (GO:0045026)10.2110881
149acrosome assembly (GO:0001675)10.1230763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.07475809
2EZH2_22144423_ChIP-Seq_EOC_Human5.29192609
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.51311822
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66642894
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.38858198
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29411037
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.00480040
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81907164
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73811597
10VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.18978194
11VDR_22108803_ChIP-Seq_LS180_Human2.18541547
12DROSHA_22980978_ChIP-Seq_HELA_Human2.13759067
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11477651
14EBNA2_21746931_ChIP-Seq_IB4-LCL_Human2.04708064
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.03578641
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.00935739
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.98562013
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.98041240
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97993110
20RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.96829731
21ERA_21632823_ChIP-Seq_H3396_Human1.95738335
22ZNF274_21170338_ChIP-Seq_K562_Hela1.90482868
23RAC3_21632823_ChIP-Seq_H3396_Human1.85900452
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83155761
25BCL6_27268052_Chip-Seq_Bcells_Human1.80289392
26CTCF_27219007_Chip-Seq_Bcells_Human1.76375294
27ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75826948
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.74019413
29E2F1_20622854_ChIP-Seq_HELA_Human1.72033954
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.70352930
31FUS_26573619_Chip-Seq_HEK293_Human1.70117871
32SMC4_20622854_ChIP-Seq_HELA_Human1.66116984
33MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.65080573
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64544012
35BCOR_27268052_Chip-Seq_Bcells_Human1.64319706
36TAF2_19829295_ChIP-Seq_ESCs_Human1.64053675
37TDRD3_21172665_ChIP-Seq_MCF-7_Human1.62913248
38STAT1_17558387_ChIP-Seq_HELA_Human1.61834856
39PHF8_20622854_ChIP-Seq_HELA_Human1.60983428
40P68_20966046_ChIP-Seq_HELA_Human1.59759326
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.59041091
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56089586
43SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54703564
44FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54667196
45ER_23166858_ChIP-Seq_MCF-7_Human1.54386544
46KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.52202378
47CBP_20019798_ChIP-Seq_JUKART_Human1.51704270
48IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51704270
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.51562429
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.51225554
51P300_27268052_Chip-Seq_Bcells_Human1.50799827
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.50346710
53TP63_22573176_ChIP-Seq_HFKS_Human1.50138909
54OCT4_20526341_ChIP-Seq_ESCs_Human1.49612717
55REST_21632747_ChIP-Seq_MESCs_Mouse1.47351707
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46926128
57GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.43057313
58AR_25329375_ChIP-Seq_VCAP_Human1.40363143
59LXR_22292898_ChIP-Seq_THP-1_Human1.40103394
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39357525
61KDM2B_26808549_Chip-Seq_REH_Human1.38363248
62TAL1_26923725_Chip-Seq_HPCs_Mouse1.38282805
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.37154077
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35418382
65KAP1_22055183_ChIP-Seq_ESCs_Mouse1.34196558
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33378161
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33135891
68RBPJ_21746931_ChIP-Seq_IB4_Human1.32703994
69GATA3_21867929_ChIP-Seq_CD8_Mouse1.32558526
70P53_21459846_ChIP-Seq_SAOS-2_Human1.32465836
71P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.30483346
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.30260250
73HNFA_21074721_ChIP-Seq_CACO-2_Human1.30095677
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.29852991
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.29365781
76FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.28348955
77LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.26677493
78CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26106214
79ETV1_20927104_ChIP-Seq_GIST48_Human1.25577462
80CEBPB_22108803_ChIP-Seq_LS180_Human1.24769313
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24125322
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.22921658
83SMRT_27268052_Chip-Seq_Bcells_Human1.22031459
84CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20901542
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19317259
86ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19146031
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.18716817
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18039907
89SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16941921
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16912459
91GATA3_21867929_ChIP-Seq_TH1_Mouse1.16235706
92* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15599415
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14573895
94P300_19829295_ChIP-Seq_ESCs_Human1.14571259
95FLI1_21867929_ChIP-Seq_TH2_Mouse1.14386695
96GF1_26923725_Chip-Seq_HPCs_Mouse1.13130992
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13006710
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12639646
99TP53_18474530_ChIP-ChIP_U2OS_Human1.12072152
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11562562
101TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11562562
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11395926
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.11148195
104SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09341176
105ERG_20517297_ChIP-Seq_VCAP_Human1.08515117
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.08392937
107CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07984598
108HOXB7_26014856_ChIP-Seq_BT474_Human1.07868612
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06487824
110RUNX_20019798_ChIP-Seq_JUKART_Human1.06360257
111SA1_27219007_Chip-Seq_Bcells_Human1.06284339
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05392549
113EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04715973
114EZH2_27294783_Chip-Seq_ESCs_Mouse1.04338741
115PHF8_20622853_ChIP-Seq_HELA_Human1.04041827
116AR_21572438_ChIP-Seq_LNCaP_Human1.03874875
117OCT4_19829295_ChIP-Seq_ESCs_Human1.03744418
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03731245
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03528850
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03495027
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.03252616
122GATA6_21074721_ChIP-Seq_CACO-2_Human1.02779455
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.02700235
124TAF15_26573619_Chip-Seq_HEK293_Human1.02678211
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02441898
126CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00659144
127* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00283465
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.00119040
129RUNX2_22187159_ChIP-Seq_PCA_Human0.99990065
130SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99720447
131SPI1_20517297_ChIP-Seq_HL60_Human0.99347669
132* MYC_27129775_Chip-Seq_CORNEA_Mouse0.99176980
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98467944
134SPI1_26923725_Chip-Seq_HPCs_Mouse0.98407108
135SOX2_19829295_ChIP-Seq_ESCs_Human0.97926458
136NANOG_19829295_ChIP-Seq_ESCs_Human0.97926458
137NANOG_18555785_Chip-Seq_ESCs_Mouse0.97879625
138NFYA_21822215_ChIP-Seq_K562_Human0.97850431
139SMAD4_21741376_ChIP-Seq_EPCs_Human0.97249704
140CTCF_20526341_ChIP-Seq_ESCs_Human0.96905692
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96418916
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.95684002
143SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95539042
144FOXH1_21741376_ChIP-Seq_ESCs_Human0.95181113
145ESET_19884257_ChIP-Seq_ESCs_Mouse0.94293224
146OCT4_18555785_Chip-Seq_ESCs_Mouse0.94245196
147SOX2_21211035_ChIP-Seq_LN229_Human0.93663953
148CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93038598
149TBL1_22424771_ChIP-Seq_293T_Human0.92772129
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.92738652
151OCT4_21477851_ChIP-Seq_ESCs_Mouse0.92313772
152ELF1_20517297_ChIP-Seq_JURKAT_Human0.91900330
153NFYB_21822215_ChIP-Seq_K562_Human0.90877546
154P53_22387025_ChIP-Seq_ESCs_Mouse0.90626806
155MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90367997
156SMAD3_21741376_ChIP-Seq_ESCs_Human0.90331460
157MYC_19829295_ChIP-Seq_ESCs_Human0.89805783
158* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88961475
159GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88021994
160EZH2_27294783_Chip-Seq_NPCs_Mouse0.87975818
161SOX11_22085726_ChIP-Seq_ESNs_Mouse0.86735137
162NANOG_20526341_ChIP-Seq_ESCs_Human0.86590264
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86442357
164RARA_24833708_ChIP-Seq_LIVER_Mouse0.86067016
165PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85221226
166OCT1_27270436_Chip-Seq_PROSTATE_Human0.85079293
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85068412
168* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.83904868

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.85695114
2MP0001929_abnormal_gametogenesis5.20174476
3MP0008877_abnormal_DNA_methylation4.21509317
4MP0001348_abnormal_lacrimal_gland3.37572701
5MP0002210_abnormal_sex_determination3.30944367
6MP0002161_abnormal_fertility/fecundity3.19957949
7MP0005670_abnormal_white_adipose3.02235436
8MP0002653_abnormal_ependyma_morphology2.81907941
9MP0001145_abnormal_male_reproductive2.75995030
10MP0000653_abnormal_sex_gland2.39724228
11MP0000678_abnormal_parathyroid_gland2.38301752
12MP0003718_maternal_effect2.24305177
13MP0005410_abnormal_fertilization15.7558777
14MP0002132_abnormal_respiratory_system1.97464276
15MP0005310_abnormal_salivary_gland1.89190219
16MP0003878_abnormal_ear_physiology1.83081740
17MP0005377_hearing/vestibular/ear_phenot1.83081740
18MP0005623_abnormal_meninges_morphology1.77555219
19MP0002160_abnormal_reproductive_system1.73247764
20MP0005379_endocrine/exocrine_gland_phen1.72938808
21MP0003646_muscle_fatigue1.62695142
22MP0002822_catalepsy1.47622909
23MP0004233_abnormal_muscle_weight1.40791399
24MP0002249_abnormal_larynx_morphology1.39373542
25MP0002282_abnormal_trachea_morphology1.34920443
26MP0001485_abnormal_pinna_reflex1.31079041
27MP0002138_abnormal_hepatobiliary_system1.29611050
28MP0009046_muscle_twitch1.25741015
29MP0009053_abnormal_anal_canal1.24304977
30MP0005423_abnormal_somatic_nervous1.23094474
31MP0004510_myositis1.22733911
32MP0002735_abnormal_chemical_nociception1.22249114
33MP0001984_abnormal_olfaction1.19006171
34MP0002127_abnormal_cardiovascular_syste1.16008478
35MP0004859_abnormal_synaptic_plasticity1.15874175
36MP0005647_abnormal_sex_gland1.13914543
37MP0001765_abnormal_ion_homeostasis1.10690629
38MP0000534_abnormal_ureter_morphology1.08959652
39MP0003011_delayed_dark_adaptation1.05633559
40MP0001963_abnormal_hearing_physiology1.03009239
41MP0002733_abnormal_thermal_nociception0.99066186
42MP0005395_other_phenotype0.98718461
43MP0000026_abnormal_inner_ear0.96138968
44MP0004270_analgesia0.95729509
45MP0004484_altered_response_of0.92005536
46MP0003136_yellow_coat_color0.90761661
47MP0005451_abnormal_body_composition0.86226527
48MP0001905_abnormal_dopamine_level0.86173314
49MP0008995_early_reproductive_senescence0.86084184
50MP0005389_reproductive_system_phenotype0.83036970
51MP0000955_abnormal_spinal_cord0.79629299
52MP0002557_abnormal_social/conspecific_i0.79075146
53MP0003115_abnormal_respiratory_system0.78924842
54MP0005248_abnormal_Harderian_gland0.74469097
55MP0004085_abnormal_heartbeat0.73674017
56MP0002067_abnormal_sensory_capabilities0.72927394
57MP0000681_abnormal_thyroid_gland0.71875330
58MP0005666_abnormal_adipose_tissue0.71370944
59MP0009764_decreased_sensitivity_to0.70334075
60MP0008058_abnormal_DNA_repair0.70062827
61MP0002139_abnormal_hepatobiliary_system0.69815781
62MP0009745_abnormal_behavioral_response0.69729104
63MP0005365_abnormal_bile_salt0.68552681
64MP0001501_abnormal_sleep_pattern0.64434186
65MP0001970_abnormal_pain_threshold0.64062725
66MP0004885_abnormal_endolymph0.63975579
67MP0003329_amyloid_beta_deposits0.63816627
68MP0001666_abnormal_nutrient_absorption0.63680047
69MP0001324_abnormal_eye_pigmentation0.62734530
70MP0005636_abnormal_mineral_homeostasis0.59070655
71MP0008875_abnormal_xenobiotic_pharmacok0.58908606
72MP0000049_abnormal_middle_ear0.58009992
73MP0001879_abnormal_lymphatic_vessel0.57417797
74MP0005535_abnormal_body_temperature0.57379200
75MP0002928_abnormal_bile_duct0.57373347
76MP0005551_abnormal_eye_electrophysiolog0.57123667
77MP0002234_abnormal_pharynx_morphology0.56866287
78MP0001293_anophthalmia0.56313124
79MP0009115_abnormal_fat_cell0.54384452
80MP0003077_abnormal_cell_cycle0.54154360
81MP0005083_abnormal_biliary_tract0.50506945
82MP0010329_abnormal_lipoprotein_level0.50043112
83MP0000003_abnormal_adipose_tissue0.49696844
84MP0003633_abnormal_nervous_system0.49497724
85MP0003879_abnormal_hair_cell0.49492253
86MP0003699_abnormal_female_reproductive0.47397324
87MP0005174_abnormal_tail_pigmentation0.46471215
88MP0000249_abnormal_blood_vessel0.45832490
89MP0000516_abnormal_urinary_system0.45020921
90MP0005367_renal/urinary_system_phenotyp0.45020921
91MP0001764_abnormal_homeostasis0.44048330
92MP0009697_abnormal_copulation0.43585579
93MP0004133_heterotaxia0.42339399
94MP0000358_abnormal_cell_content/0.41964316
95MP0002269_muscular_atrophy0.41568669
96MP0003631_nervous_system_phenotype0.40912963
97MP0009278_abnormal_bone_marrow0.40372668
98MP0005253_abnormal_eye_physiology0.40073403
99MP0002734_abnormal_mechanical_nocicepti0.39764810
100MP0005360_urolithiasis0.39757161
101MP0002971_abnormal_brown_adipose0.39708990
102MP0000470_abnormal_stomach_morphology0.39437148
103MP0000604_amyloidosis0.39084078
104MP0005332_abnormal_amino_acid0.39021692
105MP0002736_abnormal_nociception_after0.38544276
106MP0000230_abnormal_systemic_arterial0.38129709
107MP0008961_abnormal_basal_metabolism0.37880000
108MP0005645_abnormal_hypothalamus_physiol0.37686263
109MP0004019_abnormal_vitamin_homeostasis0.36357982
110MP0005397_hematopoietic_system_phenotyp0.36324423
111MP0001545_abnormal_hematopoietic_system0.36324423
112MP0003950_abnormal_plasma_membrane0.36270750
113MP0002254_reproductive_system_inflammat0.35398234
114MP0005084_abnormal_gallbladder_morpholo0.34969458
115MP0002152_abnormal_brain_morphology0.34691193
116MP0002572_abnormal_emotion/affect_behav0.34316243
117MP0005391_vision/eye_phenotype0.34197841
118MP0002102_abnormal_ear_morphology0.33019613
119MP0008775_abnormal_heart_ventricle0.32695649
120MP0004811_abnormal_neuron_physiology0.31600158
121MP0001440_abnormal_grooming_behavior0.31573665
122MP0008874_decreased_physiological_sensi0.31474559
123MP0001986_abnormal_taste_sensitivity0.31383038
124MP0000569_abnormal_digit_pigmentation0.30788227
125MP0003137_abnormal_impulse_conducting0.30765729
126MP0003119_abnormal_digestive_system0.30490031
127MP0004742_abnormal_vestibular_system0.30388068
128MP0004036_abnormal_muscle_relaxation0.30386268
129MP0003880_abnormal_central_pattern0.30016577
130MP0000751_myopathy0.29786320
131MP0003252_abnormal_bile_duct0.29463512
132MP0001968_abnormal_touch/_nociception0.29455418
133MP0001119_abnormal_female_reproductive0.29222810
134MP0002118_abnormal_lipid_homeostasis0.29192012
135MP0003942_abnormal_urinary_system0.28792411
136MP0002272_abnormal_nervous_system0.28400584
137MP0002229_neurodegeneration0.28287820
138MP0001486_abnormal_startle_reflex0.28250811
139MP0002295_abnormal_pulmonary_circulatio0.28035186
140MP0001661_extended_life_span0.27766226
141MP0004130_abnormal_muscle_cell0.27623359
142MP0003861_abnormal_nervous_system0.27297761
143MP0003787_abnormal_imprinting0.27213951
144MP0005375_adipose_tissue_phenotype0.27060805
145MP0005085_abnormal_gallbladder_physiolo0.26531768
146MP0004858_abnormal_nervous_system0.26469769
147MP0005167_abnormal_blood-brain_barrier0.25905015
148MP0003948_abnormal_gas_homeostasis0.25415599
149MP0001502_abnormal_circadian_rhythm0.24794466
150MP0001270_distended_abdomen0.24722843
151MP0010094_abnormal_chromosome_stability0.22436331
152MP0008569_lethality_at_weaning0.22297980
153MP0002063_abnormal_learning/memory/cond0.21880743
154MP0003635_abnormal_synaptic_transmissio0.21701455
155MP0002092_abnormal_eye_morphology0.21143673
156MP0004043_abnormal_pH_regulation0.20295291

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.54997111
2Abnormal respiratory motile cilium morphology (HP:0005938)9.54997111
3Abnormal respiratory motile cilium physiology (HP:0012261)9.42347204
4Severe visual impairment (HP:0001141)8.50192445
5Abnormal ciliary motility (HP:0012262)7.78291960
6Rhinitis (HP:0012384)7.69167665
7Chronic bronchitis (HP:0004469)6.74104773
8Infertility (HP:0000789)6.64244319
9Nasal polyposis (HP:0100582)6.25662139
10Bony spicule pigmentary retinopathy (HP:0007737)5.56468321
11Attenuation of retinal blood vessels (HP:0007843)5.53917752
12Abnormality of the nasal mucosa (HP:0000433)5.13753549
13Male infertility (HP:0003251)4.87122975
14Hyperkalemia (HP:0002153)4.79898347
15Abnormal rod and cone electroretinograms (HP:0008323)4.64781701
16Bronchiectasis (HP:0002110)4.60709976
17Chronic hepatic failure (HP:0100626)4.58062466
18Resting tremor (HP:0002322)4.53163294
19Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.49896081
20Bronchitis (HP:0012387)4.48415022
21Nephronophthisis (HP:0000090)4.24741204
22Hypoplastic ischia (HP:0003175)4.12106120
23Abnormality of macular pigmentation (HP:0008002)3.96133194
24Facial shape deformation (HP:0011334)3.89592116
25Potter facies (HP:0002009)3.89592116
26Enlarged epiphyses (HP:0010580)3.71878248
27Abnormality of the ischium (HP:0003174)3.63376731
28Cone-rod dystrophy (HP:0000548)3.35120709
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.31982961
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.31067119
31Abnormal spermatogenesis (HP:0008669)3.30562001
32Recurrent sinusitis (HP:0011108)3.25052000
33Recurrent otitis media (HP:0000403)3.24189767
34Abnormality of the renal medulla (HP:0100957)3.22155478
35Hypoplasia of the thymus (HP:0000778)3.19727033
36Tubulointerstitial nephritis (HP:0001970)3.03721972
37Unilateral renal agenesis (HP:0000122)3.02360203
38Recurrent bronchitis (HP:0002837)2.97955189
39Postural instability (HP:0002172)2.97832713
40Impulsivity (HP:0100710)2.89175276
41Progressive sensorineural hearing impairment (HP:0000408)2.78899629
42Abnormality of potassium homeostasis (HP:0011042)2.69029645
43Abnormality of the aortic arch (HP:0012303)2.66137028
44Double outlet right ventricle (HP:0001719)2.64656115
45Congenital malformation of the right heart (HP:0011723)2.64656115
46Gonadotropin excess (HP:0000837)2.63829819
47Generalized aminoaciduria (HP:0002909)2.55503288
48Portal hypertension (HP:0001409)2.52238013
49Hypoalphalipoproteinemia (HP:0003233)2.50614251
50Abnormality of midbrain morphology (HP:0002418)2.50053507
51Molar tooth sign on MRI (HP:0002419)2.50053507
52Tubulointerstitial abnormality (HP:0001969)2.43700142
53Progressive cerebellar ataxia (HP:0002073)2.43436703
54Amelogenesis imperfecta (HP:0000705)2.38402595
55Tubular atrophy (HP:0000092)2.38010011
56Abnormality of the costochondral junction (HP:0000919)2.32829515
57Polyuria (HP:0000103)2.32755294
58Abnormal gallbladder physiology (HP:0012438)2.31980863
59Cholecystitis (HP:0001082)2.31980863
60Abnormality of the hepatic vasculature (HP:0006707)2.30191670
61Medial flaring of the eyebrow (HP:0010747)2.28031596
62Abnormality of the lower motor neuron (HP:0002366)2.25504948
63Epiphyseal dysplasia (HP:0002656)2.24817890
64Renovascular hypertension (HP:0100817)2.24318984
65Abnormality of dental color (HP:0011073)2.18131914
66Abnormality of the parathyroid morphology (HP:0011766)2.17563442
67Menstrual irregularities (HP:0000858)2.14447364
68Insulin-resistant diabetes mellitus (HP:0000831)2.13163410
69Neoplasm of the heart (HP:0100544)2.11345128
70Abnormal biliary tract physiology (HP:0012439)2.09800066
71Bile duct proliferation (HP:0001408)2.09800066
72Hemiparesis (HP:0001269)2.08880128
73Spastic tetraparesis (HP:0001285)2.07827418
74Widely patent fontanelles and sutures (HP:0004492)2.07810958
75Azoospermia (HP:0000027)2.06412084
76Abnormality of the pubic bones (HP:0003172)2.03724639
77Abnormality of the epiphysis of the femoral head (HP:0010574)2.03496398
78Postaxial foot polydactyly (HP:0001830)2.03371637
79Recurrent pneumonia (HP:0006532)2.02243868
80Myokymia (HP:0002411)2.00157615
81Dynein arm defect of respiratory motile cilia (HP:0012255)13.1862599
82Absent/shortened dynein arms (HP:0200106)13.1862599
83Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7213259
84Hyponatremia (HP:0002902)1.98705711
85Flattened epiphyses (HP:0003071)1.98277062
86Tetany (HP:0001281)1.98060291
87Hypophosphatemic rickets (HP:0004912)1.93770142
88Ventricular tachycardia (HP:0004756)1.93530826
89Hyperthyroidism (HP:0000836)1.92469347
90Heterotopia (HP:0002282)1.89482227
91Abnormality of femoral epiphyses (HP:0006499)1.88946440
92Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.88946440
93Abnormality of chloride homeostasis (HP:0011422)1.87382997
94Optic nerve hypoplasia (HP:0000609)1.85927330
95Dyschromatopsia (HP:0007641)1.85836108
96Protuberant abdomen (HP:0001538)1.85152701
97Congenital hepatic fibrosis (HP:0002612)1.84707901
98Tubulointerstitial fibrosis (HP:0005576)1.84488882
99Photophobia (HP:0000613)1.81905153
100Osteomalacia (HP:0002749)1.81792734
101Stage 5 chronic kidney disease (HP:0003774)1.81589682
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80506027
103Abnormality of the femoral head (HP:0003368)1.79793293
104Chronic sinusitis (HP:0011109)1.77461762
105Increased purine levels (HP:0004368)1.77454501
106Hyperuricemia (HP:0002149)1.77454501
107Decreased central vision (HP:0007663)1.77401199
108Spastic paraparesis (HP:0002313)1.77188352
109Congenital sensorineural hearing impairment (HP:0008527)1.73079715
110Intellectual disability, moderate (HP:0002342)1.72047422
111Fibular hypoplasia (HP:0003038)1.71055126
112Choroideremia (HP:0001139)1.70956371
113Abnormal drinking behavior (HP:0030082)1.68521214
114Polydipsia (HP:0001959)1.68521214
115Abnormality of the dental root (HP:0006486)1.66904342
116Taurodontia (HP:0000679)1.66904342
117Abnormality of permanent molar morphology (HP:0011071)1.66904342
118Bell-shaped thorax (HP:0001591)1.66749329
119Oculomotor apraxia (HP:0000657)1.66058428
120Abnormality of dentin (HP:0010299)1.64634608
121Abnormality of the renal cortex (HP:0011035)1.63441567
122Short ribs (HP:0000773)1.61755590
123Renal dysplasia (HP:0000110)1.59670506
124Abnormality of renal excretion (HP:0011036)1.58619581
125Neurofibrillary tangles (HP:0002185)1.58101367
126Abnormality of the dental pulp (HP:0006479)1.55255057
127Abnormality of molar morphology (HP:0011070)1.54164786
128Abnormality of molar (HP:0011077)1.54164786
129Cystic liver disease (HP:0006706)1.51679871
130Postaxial hand polydactyly (HP:0001162)1.49290596
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.48758267
132Amyotrophic lateral sclerosis (HP:0007354)1.47990655
133Supernumerary spleens (HP:0009799)1.45750378
134Hemorrhage of the eye (HP:0011885)1.44544990
135Impaired proprioception (HP:0010831)1.44426599
136Pancreatic fibrosis (HP:0100732)1.41544611
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.40334646
138Abnormal urine output (HP:0012590)1.39537462
139Facial cleft (HP:0002006)1.38122328
140Absent frontal sinuses (HP:0002688)1.36873072
141Broad distal phalanx of finger (HP:0009836)1.35670884
142Aplasia/Hypoplasia of the lens (HP:0008063)1.35607317
143Microglossia (HP:0000171)1.33529205
144True hermaphroditism (HP:0010459)1.32549387
145Deformed sella turcica (HP:0002681)1.31199380
146Hypercholesterolemia (HP:0003124)1.30707224
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.30174967
148Cerebral inclusion bodies (HP:0100314)1.29366285
149Median cleft lip (HP:0000161)1.26681836
150J-shaped sella turcica (HP:0002680)1.25750821
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.25203957
152Gait imbalance (HP:0002141)1.24853519
153Congenital primary aphakia (HP:0007707)1.24467775
154Asymmetric septal hypertrophy (HP:0001670)1.24429385
155Nephropathy (HP:0000112)1.22256215
156Truncal obesity (HP:0001956)1.20229067
157Occipital encephalocele (HP:0002085)1.19900337
158Loss of speech (HP:0002371)1.19003991
159Short thorax (HP:0010306)1.18447578
160Abnormality of ocular smooth pursuit (HP:0000617)1.15247418
161Pachygyria (HP:0001302)1.14868674
162Abnormality of saccadic eye movements (HP:0000570)1.14170722
163Absent epiphyses (HP:0010577)1.14025465
164Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.14025465
165Bundle branch block (HP:0011710)1.11020195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.69647790
2PDK37.69647790
3PRKD36.56438844
4TESK15.89320154
5DDR25.08837355
6PDK24.88426435
7ICK4.50405291
8MAP4K23.37422300
9INSRR3.31426094
10PLK22.81229265
11BRD42.67925881
12PNCK2.56713439
13PTK2B2.32592163
14WNK42.00754615
15MAP3K91.98486892
16BLK1.93315847
17STK391.83930879
18MAPK151.77373695
19MST1R1.75072357
20STK381.71316386
21DYRK1B1.67067404
22PIK3CG1.60979180
23NEK21.52215670
24CAMK1D1.50535375
25CDK71.25897385
26CAMK1G1.06058198
27PDK10.98828385
28TYRO30.96246991
29KSR20.93553815
30DYRK30.90467261
31WNK10.86585695
32MUSK0.84220974
33MAP3K110.76779599
34RPS6KA20.75751931
35EEF2K0.73620794
36UHMK10.71355704
37TNIK0.67387810
38CCNB10.65696150
39LMTK20.65138206
40CAMK40.61850234
41BRAF0.61440054
42MAP2K60.61383532
43NTRK20.61330108
44AKT30.60851445
45PINK10.59601051
46LATS20.59370708
47MAP3K80.58230030
48ROCK10.57421488
49PASK0.55052584
50PDPK10.54153498
51NEK60.53767425
52FRK0.53049143
53STK30.52657992
54MAP2K20.50677161
55RPS6KA60.49365524
56RPS6KL10.49347255
57RPS6KC10.49347255
58IRAK10.45960288
59TTK0.44790351
60MAP3K20.44569472
61SGK2230.42486293
62SGK4940.42486293
63BMPR1B0.42273746
64PAK20.40584511
65MAPK10.39791406
66CHEK20.38333271
67NTRK30.37513389
68MARK20.37319966
69PRKCG0.37148356
70RIPK40.34798377
71PAK10.34751205
72MAP3K10.33007002
73MTOR0.32725758
74MARK10.32633813
75TESK20.31781217
76CHEK10.30760572
77LATS10.30559057
78ARAF0.30342095
79SGK10.28752870
80PRKAA10.28580571
81PLK40.28189978
82MAPK140.27208528
83RPS6KB10.25211613
84IRAK20.24823978
85ATM0.22458670
86TNK20.21834895
87IKBKB0.21729977
88CAMKK20.21537429
89CAMKK10.20524553
90PRKD20.20325421
91MAPK110.20152365
92PAK40.19683080
93CDK120.19136803
94MET0.19104539
95ATR0.18809445
96OXSR10.18286938
97ZAK0.17886289
98ADRBK20.17328158
99PRKCZ0.17268848
100MAPK100.16552775
101PHKG20.15227946
102PHKG10.15227946
103WEE10.14823116
104TIE10.14290569
105AKT10.14246318
106FER0.13821017
107STK110.13801847
108JAK30.13102828
109MAPKAPK50.11548405
110PRKCQ0.11520267
111CDK90.11008955
112SGK20.10987857
113DYRK20.10792012
114PRKCE0.10526917
115MAP3K100.10141994
116CDK30.10138929
117PAK60.10114421
118CAMK10.09070556
119BRSK10.08925018
120PRKACG0.08337741
121MAPKAPK30.07684334
122PRKAA20.07637886
123RIPK10.07599632
124PRKG10.07500369
125GSK3B0.07454610
126MAP3K40.07180473
127CSNK1D0.06627453
128CSK0.06267071
129CAMK2A0.06106607
130PLK10.04932965
131TAOK10.04659755
132PRKG20.03966218
133CDK150.03920589
134CDK60.03439797
135CDC70.02852280
136STK38L0.02849999
137RPS6KA30.02567747
138PRKCB0.02536271
139PRKACB0.02336577
140CDK40.01902110
141CSF1R0.01666047
142PRKCA0.01398875
143CLK10.01392631
144PKN10.01390836
145CDK180.00885361
146SIK20.00845618
147CSNK2A10.00768635
148CDK10.00510246
149PRKDC0.00505701
150MAPK80.00267964
151CDK11A0.00265208
152PRKACA-0.0085157
153EGFR-0.0075664
154CDK2-0.0059716
155RPS6KA1-0.0020042

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.94024707
2Fatty acid biosynthesis_Homo sapiens_hsa000614.46182439
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.92903341
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.79152140
5Pyruvate metabolism_Homo sapiens_hsa006203.37024292
6Vitamin B6 metabolism_Homo sapiens_hsa007502.95951967
7Propanoate metabolism_Homo sapiens_hsa006402.80441240
8Butanoate metabolism_Homo sapiens_hsa006502.78586789
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.52953275
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46635945
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.44429855
12Glucagon signaling pathway_Homo sapiens_hsa049222.38924857
13Linoleic acid metabolism_Homo sapiens_hsa005912.36364226
14Glycerolipid metabolism_Homo sapiens_hsa005612.19522110
15PPAR signaling pathway_Homo sapiens_hsa033202.16596887
16Dorso-ventral axis formation_Homo sapiens_hsa043202.15143864
17Selenocompound metabolism_Homo sapiens_hsa004502.06781896
18Fatty acid metabolism_Homo sapiens_hsa012121.76029102
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.75302610
20Allograft rejection_Homo sapiens_hsa053301.73185514
21Fatty acid degradation_Homo sapiens_hsa000711.72388350
22Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71622450
23Type I diabetes mellitus_Homo sapiens_hsa049401.67261221
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64875582
25Autoimmune thyroid disease_Homo sapiens_hsa053201.64716889
26Nitrogen metabolism_Homo sapiens_hsa009101.64294824
27Fructose and mannose metabolism_Homo sapiens_hsa000511.62355606
28Mineral absorption_Homo sapiens_hsa049781.60060006
29Basal transcription factors_Homo sapiens_hsa030221.56904600
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55568278
31Type II diabetes mellitus_Homo sapiens_hsa049301.50946672
32Graft-versus-host disease_Homo sapiens_hsa053321.44573621
33Amphetamine addiction_Homo sapiens_hsa050311.44111922
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.40423818
35Phenylalanine metabolism_Homo sapiens_hsa003601.40362392
36Oocyte meiosis_Homo sapiens_hsa041141.39941213
37Phototransduction_Homo sapiens_hsa047441.35367626
38Bile secretion_Homo sapiens_hsa049761.33522308
39Renin secretion_Homo sapiens_hsa049241.23305016
40Carbon metabolism_Homo sapiens_hsa012001.22837682
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22430550
42Fat digestion and absorption_Homo sapiens_hsa049751.21415451
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.15793580
44Pentose phosphate pathway_Homo sapiens_hsa000301.15552633
45Arginine and proline metabolism_Homo sapiens_hsa003301.13214558
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13070583
47Morphine addiction_Homo sapiens_hsa050321.09180980
48Fanconi anemia pathway_Homo sapiens_hsa034601.03767138
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03350736
50Cardiac muscle contraction_Homo sapiens_hsa042601.02378968
51Ether lipid metabolism_Homo sapiens_hsa005650.99728083
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.98800214
53Viral myocarditis_Homo sapiens_hsa054160.98261683
54Insulin secretion_Homo sapiens_hsa049110.97721920
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97080326
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.95185431
57ABC transporters_Homo sapiens_hsa020100.94607373
58Arginine biosynthesis_Homo sapiens_hsa002200.93531323
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91364750
60Chemical carcinogenesis_Homo sapiens_hsa052040.89580211
61Antigen processing and presentation_Homo sapiens_hsa046120.86114014
62Thyroid hormone synthesis_Homo sapiens_hsa049180.83382037
63Huntingtons disease_Homo sapiens_hsa050160.81231015
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.80901830
65Purine metabolism_Homo sapiens_hsa002300.79378721
66Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79209852
67Biosynthesis of amino acids_Homo sapiens_hsa012300.78006568
68mRNA surveillance pathway_Homo sapiens_hsa030150.74829495
69Hedgehog signaling pathway_Homo sapiens_hsa043400.73767834
70Long-term potentiation_Homo sapiens_hsa047200.70467922
71Calcium signaling pathway_Homo sapiens_hsa040200.70211064
72Gastric acid secretion_Homo sapiens_hsa049710.69478416
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69360233
74Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69345592
75Glutathione metabolism_Homo sapiens_hsa004800.68366980
76Serotonergic synapse_Homo sapiens_hsa047260.66972047
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66563968
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.66293174
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65224933
80Regulation of autophagy_Homo sapiens_hsa041400.64949977
81Salivary secretion_Homo sapiens_hsa049700.64795728
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64693788
83Estrogen signaling pathway_Homo sapiens_hsa049150.63262187
84Influenza A_Homo sapiens_hsa051640.61755596
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61271707
86Tyrosine metabolism_Homo sapiens_hsa003500.58946117
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58291827
88Pancreatic secretion_Homo sapiens_hsa049720.57108144
89Renin-angiotensin system_Homo sapiens_hsa046140.56471776
90MAPK signaling pathway_Homo sapiens_hsa040100.55507593
91Vitamin digestion and absorption_Homo sapiens_hsa049770.54973599
92Olfactory transduction_Homo sapiens_hsa047400.54280953
93Taste transduction_Homo sapiens_hsa047420.54178140
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.54147607
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.53510315
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53119298
97Protein digestion and absorption_Homo sapiens_hsa049740.52666731
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50383679
99Arachidonic acid metabolism_Homo sapiens_hsa005900.50191122
100cAMP signaling pathway_Homo sapiens_hsa040240.50031456
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49094693
102Cholinergic synapse_Homo sapiens_hsa047250.48963697
103Circadian entrainment_Homo sapiens_hsa047130.46424367
104RNA transport_Homo sapiens_hsa030130.46315371
105B cell receptor signaling pathway_Homo sapiens_hsa046620.44204389
106AMPK signaling pathway_Homo sapiens_hsa041520.42786340
107GABAergic synapse_Homo sapiens_hsa047270.42367554
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40425977
109Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39864917
110VEGF signaling pathway_Homo sapiens_hsa043700.39711591
111Inositol phosphate metabolism_Homo sapiens_hsa005620.37711264
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36842244
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35635683
114Complement and coagulation cascades_Homo sapiens_hsa046100.33746192
115Cocaine addiction_Homo sapiens_hsa050300.33330822
116Caffeine metabolism_Homo sapiens_hsa002320.33289868
117Legionellosis_Homo sapiens_hsa051340.32430641
118Retinol metabolism_Homo sapiens_hsa008300.32233799
119Collecting duct acid secretion_Homo sapiens_hsa049660.31936296
120Tryptophan metabolism_Homo sapiens_hsa003800.31811226
121Metabolic pathways_Homo sapiens_hsa011000.30529517
122Glutamatergic synapse_Homo sapiens_hsa047240.30463159
123Peroxisome_Homo sapiens_hsa041460.30315089
124Acute myeloid leukemia_Homo sapiens_hsa052210.30314109
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.30072432
126Oxytocin signaling pathway_Homo sapiens_hsa049210.29868710
127Synaptic vesicle cycle_Homo sapiens_hsa047210.28673928
128Endocytosis_Homo sapiens_hsa041440.28300018
129Tight junction_Homo sapiens_hsa045300.28169330
130Viral carcinogenesis_Homo sapiens_hsa052030.24762704
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.21603278
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.20770823
133Nicotine addiction_Homo sapiens_hsa050330.20687710
134Basal cell carcinoma_Homo sapiens_hsa052170.20033997
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19581976
136Sulfur metabolism_Homo sapiens_hsa009200.18802129
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.18634292
138FoxO signaling pathway_Homo sapiens_hsa040680.17431466
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16534129
140Herpes simplex infection_Homo sapiens_hsa051680.15620253

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