TTPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)9.38698750
2omega-hydroxylase P450 pathway (GO:0097267)7.90226392
3epoxygenase P450 pathway (GO:0019373)7.64783283
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61874610
5L-phenylalanine catabolic process (GO:0006559)7.61874610
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27137806
7L-phenylalanine metabolic process (GO:0006558)7.27137806
8aromatic amino acid family catabolic process (GO:0009074)6.84348462
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.37191424
10oxidative demethylation (GO:0070989)6.16968978
11indole-containing compound catabolic process (GO:0042436)6.14697338
12indolalkylamine catabolic process (GO:0046218)6.14697338
13tryptophan catabolic process (GO:0006569)6.14697338
14kynurenine metabolic process (GO:0070189)6.03009422
15bile acid biosynthetic process (GO:0006699)5.99045059
16tryptophan metabolic process (GO:0006568)5.79698894
17urea metabolic process (GO:0019627)5.75879900
18urea cycle (GO:0000050)5.75879900
19drug metabolic process (GO:0017144)5.75248344
20glyoxylate metabolic process (GO:0046487)5.73216704
21alpha-linolenic acid metabolic process (GO:0036109)5.71527647
22negative regulation of fibrinolysis (GO:0051918)5.59776900
23high-density lipoprotein particle remodeling (GO:0034375)5.54733245
24cysteine metabolic process (GO:0006534)5.41763625
25regulation of fibrinolysis (GO:0051917)5.37926111
26sulfur amino acid catabolic process (GO:0000098)5.37125903
27protein carboxylation (GO:0018214)5.34343388
28peptidyl-glutamic acid carboxylation (GO:0017187)5.34343388
29complement activation, alternative pathway (GO:0006957)5.33170758
30regulation of protein activation cascade (GO:2000257)5.29459922
31nitrogen cycle metabolic process (GO:0071941)5.29403384
32S-adenosylmethionine metabolic process (GO:0046500)5.26290989
33serine family amino acid catabolic process (GO:0009071)5.15758309
34bile acid metabolic process (GO:0008206)5.13999802
35aromatic amino acid family metabolic process (GO:0009072)4.97003372
36regulation of complement activation (GO:0030449)4.92783027
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.92512315
38homocysteine metabolic process (GO:0050667)4.89160389
39regulation of triglyceride catabolic process (GO:0010896)4.87810347
40regulation of cholesterol esterification (GO:0010872)4.86957764
41tyrosine metabolic process (GO:0006570)4.84646539
42reverse cholesterol transport (GO:0043691)4.84592101
43protein-lipid complex remodeling (GO:0034368)4.79093630
44macromolecular complex remodeling (GO:0034367)4.79093630
45plasma lipoprotein particle remodeling (GO:0034369)4.79093630
46ethanol metabolic process (GO:0006067)4.73492530
47amino-acid betaine metabolic process (GO:0006577)4.70497145
48alpha-amino acid catabolic process (GO:1901606)4.69095135
49lysine catabolic process (GO:0006554)4.63582783
50lysine metabolic process (GO:0006553)4.63582783
51triglyceride homeostasis (GO:0070328)4.61390408
52acylglycerol homeostasis (GO:0055090)4.61390408
53negative regulation of cholesterol transport (GO:0032375)4.58910172
54negative regulation of sterol transport (GO:0032372)4.58910172
55phospholipid efflux (GO:0033700)4.56838746
56phenylpropanoid metabolic process (GO:0009698)4.55634515
57glycine metabolic process (GO:0006544)4.46069909
58cellular ketone body metabolic process (GO:0046950)4.43789635
59bile acid and bile salt transport (GO:0015721)4.42876486
60alkaloid metabolic process (GO:0009820)4.37620202
61plasma lipoprotein particle clearance (GO:0034381)4.36548136
62indolalkylamine metabolic process (GO:0006586)4.35671182
63coenzyme catabolic process (GO:0009109)4.34819209
64imidazole-containing compound metabolic process (GO:0052803)4.33593405
65cellular glucuronidation (GO:0052695)4.33389325
66cellular amino acid catabolic process (GO:0009063)4.31587295
67glutamate metabolic process (GO:0006536)4.27783995
68cellular biogenic amine catabolic process (GO:0042402)4.26315854
69amine catabolic process (GO:0009310)4.26315854
70serine family amino acid metabolic process (GO:0009069)4.23457355
71cholesterol efflux (GO:0033344)4.21479203
72benzene-containing compound metabolic process (GO:0042537)4.13217352
73serine family amino acid biosynthetic process (GO:0009070)4.08485968
74low-density lipoprotein particle remodeling (GO:0034374)4.08466046
75dicarboxylic acid biosynthetic process (GO:0043650)4.08306773
76cellular modified amino acid catabolic process (GO:0042219)4.07637581
77ethanol oxidation (GO:0006069)4.06639422
78arginine metabolic process (GO:0006525)4.04056886
79disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.01032383
80killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.01032383
81drug catabolic process (GO:0042737)4.00367622
82plasma lipoprotein particle assembly (GO:0034377)3.98838544
83aldehyde catabolic process (GO:0046185)3.97953349
84fibrinolysis (GO:0042730)3.97445336
85ketone body metabolic process (GO:1902224)3.84239498
86glucuronate metabolic process (GO:0019585)3.83598586
87uronic acid metabolic process (GO:0006063)3.83598586
88blood coagulation, intrinsic pathway (GO:0007597)3.82895145
89positive regulation of lipid catabolic process (GO:0050996)3.78859293
90positive regulation of triglyceride lipase activity (GO:0061365)3.78263088
91positive regulation of lipoprotein lipase activity (GO:0051006)3.78263088
92carboxylic acid catabolic process (GO:0046395)3.77978237
93organic acid catabolic process (GO:0016054)3.77978237
94very-low-density lipoprotein particle assembly (GO:0034379)3.77244079
95regulation of bile acid biosynthetic process (GO:0070857)3.76491181
96negative regulation of lipase activity (GO:0060192)3.75928810
97cofactor catabolic process (GO:0051187)3.75902927
98phospholipid homeostasis (GO:0055091)3.74935134
99cholesterol homeostasis (GO:0042632)3.74007946
100complement activation, classical pathway (GO:0006958)3.72195787
101complement activation (GO:0006956)3.70816316
102acetyl-CoA metabolic process (GO:0006084)3.69834200
103protein activation cascade (GO:0072376)3.69776734
104behavioral response to nicotine (GO:0035095)3.69776139
105short-chain fatty acid metabolic process (GO:0046459)3.68549779
106sterol homeostasis (GO:0055092)3.67855348
107sodium-independent organic anion transport (GO:0043252)3.67656244
108regulation of plasminogen activation (GO:0010755)3.65769690
109plasma lipoprotein particle organization (GO:0071827)3.62538709
110amino acid salvage (GO:0043102)3.62531490
111L-methionine salvage (GO:0071267)3.62531490
112L-methionine biosynthetic process (GO:0071265)3.62531490
113regulation of cholesterol homeostasis (GO:2000188)3.61015069
114cytolysis (GO:0019835)3.59557894
115negative regulation of protein activation cascade (GO:2000258)3.59252816
116protein-lipid complex assembly (GO:0065005)3.56992305
117flavonoid metabolic process (GO:0009812)3.56801102
118opsonization (GO:0008228)3.52476237
119intestinal cholesterol absorption (GO:0030299)3.50311473
120heme transport (GO:0015886)3.50131036
121negative regulation of hemostasis (GO:1900047)3.47871064
122negative regulation of blood coagulation (GO:0030195)3.47871064
123xenobiotic metabolic process (GO:0006805)3.47329772
124positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40217707
125regulation of humoral immune response (GO:0002920)3.37021687
126pyrimidine nucleobase catabolic process (GO:0006208)3.33006381
127negative regulation of coagulation (GO:0050819)3.25538998
128acute-phase response (GO:0006953)3.23856769
129xenobiotic catabolic process (GO:0042178)3.21415989
130negative regulation of wound healing (GO:0061045)3.12944019
131drug transmembrane transport (GO:0006855)3.08817444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.46645856
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21906350
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07655153
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.53680239
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32975137
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17872530
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.88120640
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.08229042
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01486043
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.99948043
11ZNF274_21170338_ChIP-Seq_K562_Hela2.81789548
12GBX2_23144817_ChIP-Seq_PC3_Human2.62571186
13IGF1R_20145208_ChIP-Seq_DFB_Human2.45164307
14VDR_22108803_ChIP-Seq_LS180_Human2.34420773
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29809526
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16928525
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10051766
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00321023
19* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9724237
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98279014
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94300321
22ER_23166858_ChIP-Seq_MCF-7_Human1.85919488
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82121603
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80952679
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.70073662
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.68588011
27P300_19829295_ChIP-Seq_ESCs_Human1.67805192
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.61064878
29EZH2_22144423_ChIP-Seq_EOC_Human1.60855360
30FOXA2_19822575_ChIP-Seq_HepG2_Human1.60526198
31CLOCK_20551151_ChIP-Seq_293T_Human1.58500093
32HTT_18923047_ChIP-ChIP_STHdh_Human1.58090943
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.54893881
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53559191
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.50584825
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48335085
37GATA1_22025678_ChIP-Seq_K562_Human1.43322549
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43136039
39* FUS_26573619_Chip-Seq_HEK293_Human1.41387257
40IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41252116
41CBP_20019798_ChIP-Seq_JUKART_Human1.41252116
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40310248
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.39442320
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38291400
45SOX2_19829295_ChIP-Seq_ESCs_Human1.35409899
46NANOG_19829295_ChIP-Seq_ESCs_Human1.35409899
47STAT3_23295773_ChIP-Seq_U87_Human1.35239007
48TCF4_23295773_ChIP-Seq_U87_Human1.33337688
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.31988376
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31988376
51* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29696448
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29533145
53* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28565318
54EWS_26573619_Chip-Seq_HEK293_Human1.27159845
55* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.27111833
56SMAD4_21799915_ChIP-Seq_A2780_Human1.25632261
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25445677
58AR_25329375_ChIP-Seq_VCAP_Human1.25334779
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.25310233
60* TCF4_22108803_ChIP-Seq_LS180_Human1.25141833
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24796460
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24390921
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23552679
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22712720
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21843172
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20032468
67RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19396864
68RUNX2_22187159_ChIP-Seq_PCA_Human1.19060750
69* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18549476
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18063847
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16490036
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16024031
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12292428
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12262034
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11102018
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10380615
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.09498527
78P53_22387025_ChIP-Seq_ESCs_Mouse1.08924598
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07809068
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.07589909
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.07447370
82PHF8_20622853_ChIP-Seq_HELA_Human1.05956294
83OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05882932
84TP53_22573176_ChIP-Seq_HFKS_Human1.04652673
85REST_21632747_ChIP-Seq_MESCs_Mouse1.04401703
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.03077686
87CBX2_27304074_Chip-Seq_ESCs_Mouse1.02622844
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.02553203
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.02378101
90EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99014775
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98952234
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98844025
93CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.98755761
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97847223
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97702262
96E2F1_18555785_Chip-Seq_ESCs_Mouse0.97316372
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97006541
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96934864
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96934864
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95540668
101TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92444076
102SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91689600
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85470382
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85329098
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83192945
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.81246037
107GATA4_25053715_ChIP-Seq_YYC3_Human0.80938249
108ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79103086
109KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78825610
110RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78808483
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77227398
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75903179
113RARA_24833708_ChIP-Seq_LIVER_Mouse0.73669834
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72950233
115ZNF263_19887448_ChIP-Seq_K562_Human0.72438345
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71270805
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69737211
118* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.69480316
119SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68028239
120ESR2_21235772_ChIP-Seq_MCF-7_Human0.65584836
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64479565
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64479565
123RARB_24833708_ChIP-Seq_LIVER_Mouse0.62142002
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61375530
125NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60532432
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.59923277
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59271127
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.58818125
129CEBPB_22108803_ChIP-Seq_LS180_Human0.58138292
130NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57674819
131* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57570832
132STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53703273
133FOXA1_25552417_ChIP-Seq_VCAP_Human0.53519727
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52835120
135AR_20517297_ChIP-Seq_VCAP_Human0.52538699
136EGR1_19032775_ChIP-ChIP_M12_Human0.52521521
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51066086
138MYC_19915707_ChIP-ChIP_AK7_Human0.49780251
139TAF15_26573619_Chip-Seq_HEK293_Human0.49714554
140ESET_19884257_ChIP-Seq_ESCs_Mouse0.49543616
141CBP_21632823_ChIP-Seq_H3396_Human0.49473345
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48459665
143LXR_22292898_ChIP-Seq_THP-1_Human0.47916120
144STAT1_17558387_ChIP-Seq_HELA_Human0.47849856
145P53_21459846_ChIP-Seq_SAOS-2_Human0.47242602
146PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46933622
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.45234883
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.43682700
149CDX2_20551321_ChIP-Seq_CACO-2_Human0.43444842
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43221594
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41494797
152PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41213951
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.40577261
154TAF2_19829295_ChIP-Seq_ESCs_Human0.40214897
155BCAT_22108803_ChIP-Seq_LS180_Human0.40196134
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40032616
157FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39191041
158GATA1_19941826_ChIP-Seq_K562_Human0.39149480
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.38650012
160GATA6_25053715_ChIP-Seq_YYC3_Human0.38471276
161GATA2_19941826_ChIP-Seq_K562_Human0.38442357
162IRF1_19129219_ChIP-ChIP_H3396_Human0.38173835
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.38055510
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37880197
165GATA1_19941827_ChIP-Seq_MEL_Mouse0.37678149
166STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36841875
167SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36567189
168LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36414295
169MYC_27129775_Chip-Seq_CORNEA_Mouse0.35637815
170CDX2_22108803_ChIP-Seq_LS180_Human0.34310082
171ERG_20517297_ChIP-Seq_VCAP_Human0.34114906
172NCOR_22424771_ChIP-Seq_293T_Human0.33781762
173FOXH1_21741376_ChIP-Seq_EPCs_Human0.33676370
174SPI1_26923725_Chip-Seq_HPCs_Mouse0.33329636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35740367
2MP0005360_urolithiasis7.48529890
3MP0005085_abnormal_gallbladder_physiolo6.50797093
4MP0005365_abnormal_bile_salt6.24300702
5MP0008875_abnormal_xenobiotic_pharmacok5.24444060
6MP0003806_abnormal_nucleotide_metabolis4.29355267
7MP0003252_abnormal_bile_duct3.94998580
8MP0010329_abnormal_lipoprotein_level3.58801721
9MP0009840_abnormal_foam_cell3.27045061
10MP0005083_abnormal_biliary_tract3.08764469
11MP0005332_abnormal_amino_acid2.78555203
12MP0003195_calcinosis2.75970886
13MP0001666_abnormal_nutrient_absorption2.60514214
14MP0003191_abnormal_cellular_cholesterol2.27929382
15MP0000609_abnormal_liver_physiology2.17631235
16* MP0002118_abnormal_lipid_homeostasis2.08310849
17MP0002138_abnormal_hepatobiliary_system2.01452309
18MP0003868_abnormal_feces_composition1.96992016
19* MP0004019_abnormal_vitamin_homeostasis1.88192299
20MP0005319_abnormal_enzyme/_coenzyme1.83936105
21MP0001764_abnormal_homeostasis1.67646087
22MP0009697_abnormal_copulation1.64657851
23MP0005584_abnormal_enzyme/coenzyme_acti1.57869605
24* MP0005551_abnormal_eye_electrophysiolog1.53930303
25MP0005451_abnormal_body_composition1.50649902
26MP0004043_abnormal_pH_regulation1.46167324
27MP0003011_delayed_dark_adaptation1.40549245
28MP0006292_abnormal_olfactory_placode1.31219469
29MP0003186_abnormal_redox_activity1.29875055
30MP0003656_abnormal_erythrocyte_physiolo1.23451995
31MP0009643_abnormal_urine_homeostasis1.22402050
32MP0005646_abnormal_pituitary_gland1.20451628
33MP0002102_abnormal_ear_morphology1.19585819
34MP0000598_abnormal_liver_morphology1.18813006
35MP0002638_abnormal_pupillary_reflex1.18045121
36MP0003705_abnormal_hypodermis_morpholog1.14843360
37MP0000372_irregular_coat_pigmentation1.14333812
38MP0005647_abnormal_sex_gland1.13482259
39MP0006072_abnormal_retinal_apoptosis1.10670064
40MP0009745_abnormal_behavioral_response1.10417676
41MP0001986_abnormal_taste_sensitivity1.07319310
42MP0000604_amyloidosis1.06573453
43MP0004885_abnormal_endolymph1.05950770
44MP0009764_decreased_sensitivity_to1.05774065
45MP0002254_reproductive_system_inflammat1.04809548
46MP0009763_increased_sensitivity_to1.03033124
47MP0003136_yellow_coat_color0.98980527
48* MP0004142_abnormal_muscle_tone0.97571638
49MP0003646_muscle_fatigue0.96715779
50MP0005253_abnormal_eye_physiology0.93343820
51MP0010368_abnormal_lymphatic_system0.92367950
52MP0005187_abnormal_penis_morphology0.92215365
53MP0005636_abnormal_mineral_homeostasis0.90303050
54MP0008877_abnormal_DNA_methylation0.88680748
55MP0005670_abnormal_white_adipose0.88379066
56MP0008469_abnormal_protein_level0.88310391
57MP0009642_abnormal_blood_homeostasis0.86633234
58MP0001968_abnormal_touch/_nociception0.86603597
59MP0005408_hypopigmentation0.84221458
60MP0006036_abnormal_mitochondrial_physio0.82955572
61MP0002272_abnormal_nervous_system0.81861447
62MP0002736_abnormal_nociception_after0.81491267
63MP0005376_homeostasis/metabolism_phenot0.80160657
64MP0009765_abnormal_xenobiotic_induced0.80104466
65MP0002282_abnormal_trachea_morphology0.79688968
66MP0002078_abnormal_glucose_homeostasis0.77015584
67MP0005084_abnormal_gallbladder_morpholo0.76640635
68MP0001919_abnormal_reproductive_system0.75533666
69MP0006276_abnormal_autonomic_nervous0.75013304
70MP0004133_heterotaxia0.74695445
71MP0002876_abnormal_thyroid_physiology0.74426688
72MP0001485_abnormal_pinna_reflex0.73986615
73MP0005220_abnormal_exocrine_pancreas0.73125933
74MP0002971_abnormal_brown_adipose0.73042517
75MP0001501_abnormal_sleep_pattern0.72706372
76MP0005379_endocrine/exocrine_gland_phen0.72577510
77MP0003567_abnormal_fetal_cardiomyocyte0.72289318
78MP0003690_abnormal_glial_cell0.70342215
79MP0004130_abnormal_muscle_cell0.69931537
80MP0005334_abnormal_fat_pad0.69157195
81MP0001661_extended_life_span0.68932075
82MP0009046_muscle_twitch0.67890596
83MP0002064_seizures0.67628707
84MP0005645_abnormal_hypothalamus_physiol0.66925984
85MP0002938_white_spotting0.66922935
86MP0005535_abnormal_body_temperature0.66868049
87MP0001324_abnormal_eye_pigmentation0.66631027
88MP0005266_abnormal_metabolism0.66139894
89MP0005377_hearing/vestibular/ear_phenot0.66011651
90MP0003878_abnormal_ear_physiology0.66011651
91MP0000569_abnormal_digit_pigmentation0.65641134
92MP0005389_reproductive_system_phenotype0.65490961
93MP0009053_abnormal_anal_canal0.65018464
94MP0001486_abnormal_startle_reflex0.64761326
95MP0002234_abnormal_pharynx_morphology0.64491959
96MP0010386_abnormal_urinary_bladder0.63226775
97MP0000639_abnormal_adrenal_gland0.60941065
98* MP0005195_abnormal_posterior_eye0.60627583
99MP0003329_amyloid_beta_deposits0.60352240
100MP0002132_abnormal_respiratory_system0.60279522
101MP0005386_behavior/neurological_phenoty0.59249344
102MP0004924_abnormal_behavior0.59249344
103MP0006035_abnormal_mitochondrial_morpho0.58789627
104MP0002160_abnormal_reproductive_system0.58678229
105MP0001756_abnormal_urination0.57545984
106MP0002909_abnormal_adrenal_gland0.57540401
107MP0001984_abnormal_olfaction0.56799669
108MP0004742_abnormal_vestibular_system0.56720494
109MP0004147_increased_porphyrin_level0.55679976
110MP0002735_abnormal_chemical_nociception0.54816729
111MP0005448_abnormal_energy_balance0.54503257
112MP0003880_abnormal_central_pattern0.54192623
113MP0000631_abnormal_neuroendocrine_gland0.54047018
114MP0005464_abnormal_platelet_physiology0.53054159
115MP0001440_abnormal_grooming_behavior0.51750556
116MP0005395_other_phenotype0.48988440
117MP0003638_abnormal_response/metabolism_0.47905551
118MP0003718_maternal_effect0.47732855
119MP0002928_abnormal_bile_duct0.46884632
120MP0008873_increased_physiological_sensi0.46720261
121MP0008874_decreased_physiological_sensi0.46505837
122MP0002136_abnormal_kidney_physiology0.44381254
123MP0002822_catalepsy0.43527705
124MP0005248_abnormal_Harderian_gland0.42761699
125MP0004782_abnormal_surfactant_physiolog0.42244191
126MP0003436_decreased_susceptibility_to0.40472578
127MP0003075_altered_response_to0.40121288
128MP0003953_abnormal_hormone_level0.40062074
129MP0005666_abnormal_adipose_tissue0.39846452
130MP0003724_increased_susceptibility_to0.39688656
131MP0008872_abnormal_physiological_respon0.39559171
132MP0002837_dystrophic_cardiac_calcinosis0.38614076
133MP0009672_abnormal_birth_weight0.37800064
134MP0005166_decreased_susceptibility_to0.36294236
135MP0004381_abnormal_hair_follicle0.34970485
136MP0000579_abnormal_nail_morphology0.34443838
137MP0009115_abnormal_fat_cell0.33923764
138MP0001853_heart_inflammation0.32826725
139MP0001881_abnormal_mammary_gland0.32768052
140MP0009384_cardiac_valve_regurgitation0.32202654
141MP0002796_impaired_skin_barrier0.31991843
142MP0000249_abnormal_blood_vessel0.31706802
143MP0000230_abnormal_systemic_arterial0.31454755
144MP0001243_abnormal_dermal_layer0.31040945
145MP0002970_abnormal_white_adipose0.30724448
146MP0004883_abnormal_blood_vessel0.30361423
147MP0002168_other_aberrant_phenotype0.30151177
148MP0006082_CNS_inflammation0.28799152
149MP0001845_abnormal_inflammatory_respons0.27412662
150MP0002060_abnormal_skin_morphology0.24496164
151MP0002090_abnormal_vision0.24245982
152MP0005164_abnormal_response_to0.24120528
153MP0000427_abnormal_hair_cycle0.24062779

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.54680321
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.52391590
3Intrahepatic cholestasis (HP:0001406)7.44569987
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.86443165
5Hypobetalipoproteinemia (HP:0003563)6.67535879
6Prolonged partial thromboplastin time (HP:0003645)6.64557557
7* Xanthomatosis (HP:0000991)5.96008899
8Complement deficiency (HP:0004431)5.36635548
9Hypolipoproteinemia (HP:0010981)4.93429632
10Joint hemorrhage (HP:0005261)4.82961549
11* Hyperlipoproteinemia (HP:0010980)4.79856652
12Hyperammonemia (HP:0001987)4.73467487
13Abnormality of the common coagulation pathway (HP:0010990)4.54229886
14Hyperglycinemia (HP:0002154)4.47818861
15Abnormality of methionine metabolism (HP:0010901)4.45528334
16Abnormality of sulfur amino acid metabolism (HP:0004339)4.35617771
17Ketosis (HP:0001946)4.30769806
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.27795658
19Hypoalphalipoproteinemia (HP:0003233)4.25613591
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.21807298
21Fat malabsorption (HP:0002630)4.21521288
22* Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14328034
23Abnormality of pyrimidine metabolism (HP:0004353)3.98921936
24Hyperglycinuria (HP:0003108)3.96856695
25Abnormality of glycine metabolism (HP:0010895)3.96435734
26Abnormality of serine family amino acid metabolism (HP:0010894)3.96435734
27Hypoglycemic coma (HP:0001325)3.91315445
28Abnormality of complement system (HP:0005339)3.90754350
29Abnormality of the intrinsic pathway (HP:0010989)3.81599108
30Conjugated hyperbilirubinemia (HP:0002908)3.80443651
31* Epidermoid cyst (HP:0200040)3.73954518
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42983825
33Hyperbilirubinemia (HP:0002904)3.40092274
34Abnormality of fatty-acid metabolism (HP:0004359)3.38576727
35* Hypercholesterolemia (HP:0003124)3.20769710
36Steatorrhea (HP:0002570)3.17143986
37Delayed CNS myelination (HP:0002188)3.16554285
38Abnormality of serum amino acid levels (HP:0003112)3.15752044
39Abnormality of nucleobase metabolism (HP:0010932)3.13154020
40Congenital stationary night blindness (HP:0007642)3.10117998
41Spontaneous abortion (HP:0005268)3.09648142
42Ketoacidosis (HP:0001993)3.04811706
43Hepatocellular carcinoma (HP:0001402)3.02450104
44Fair hair (HP:0002286)3.00039568
45Hypochromic microcytic anemia (HP:0004840)2.97446905
46Myocardial infarction (HP:0001658)2.91906799
47Metabolic acidosis (HP:0001942)2.79336534
48Pancreatic cysts (HP:0001737)2.70961423
49Abnormality of purine metabolism (HP:0004352)2.70270062
50Systemic lupus erythematosus (HP:0002725)2.68369018
51Acanthocytosis (HP:0001927)2.66065603
52Lethargy (HP:0001254)2.65777205
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.61077845
54Dicarboxylic aciduria (HP:0003215)2.61077845
55Vascular calcification (HP:0004934)2.59046767
56Spastic diplegia (HP:0001264)2.57463534
57Abnormality of alanine metabolism (HP:0010916)2.57009242
58Hyperalaninemia (HP:0003348)2.57009242
59Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.57009242
60Hypoglycemic seizures (HP:0002173)2.50777310
61Glomerulonephritis (HP:0000099)2.49608996
62Cerebral edema (HP:0002181)2.48390018
63Abnormality of urine glucose concentration (HP:0011016)2.48353463
64Glycosuria (HP:0003076)2.48353463
65Abnormal gallbladder morphology (HP:0012437)2.47366818
66Gout (HP:0001997)2.46365774
67Abnormality of the renal cortex (HP:0011035)2.43122345
68Cholelithiasis (HP:0001081)2.40979672
69Bile duct proliferation (HP:0001408)2.40287492
70Abnormal biliary tract physiology (HP:0012439)2.40287492
71Irritability (HP:0000737)2.40064450
72Arthropathy (HP:0003040)2.39206839
73Cholecystitis (HP:0001082)2.38999791
74Abnormal gallbladder physiology (HP:0012438)2.38999791
75True hermaphroditism (HP:0010459)2.38725142
76Neonatal onset (HP:0003623)2.36801836
77Mitral stenosis (HP:0001718)2.36621386
78Molar tooth sign on MRI (HP:0002419)2.34046901
79Abnormality of midbrain morphology (HP:0002418)2.34046901
80Generalized hypopigmentation of hair (HP:0011358)2.32873687
81Pancreatic fibrosis (HP:0100732)2.31537086
82Amyloidosis (HP:0011034)2.29398324
83Cardiovascular calcification (HP:0011915)2.29324046
84Malnutrition (HP:0004395)2.29022478
85Pendular nystagmus (HP:0012043)2.28839066
86Recurrent gram-negative bacterial infections (HP:0005420)2.26931873
87Chronic hepatic failure (HP:0100626)2.26208282
88Esophageal varix (HP:0002040)2.23984949
89Gingival bleeding (HP:0000225)2.23576096
90Hyperphosphaturia (HP:0003109)2.17918858
91Brushfield spots (HP:0001088)2.17071384
92* Skin nodule (HP:0200036)2.17057978
93Pancreatitis (HP:0001733)2.15740532
94Sensorimotor neuropathy (HP:0007141)2.15249387
95Menorrhagia (HP:0000132)2.14670212
96Late onset (HP:0003584)2.13312932
97Thrombophlebitis (HP:0004418)2.10996427
98Enlarged kidneys (HP:0000105)2.10900760
99Nephronophthisis (HP:0000090)2.10040428
100Vomiting (HP:0002013)2.08342936
101Poikilocytosis (HP:0004447)2.04602617
102Generalized aminoaciduria (HP:0002909)2.04536351
103Hyperinsulinemic hypoglycemia (HP:0000825)2.03700114
104Opisthotonus (HP:0002179)2.03591751
105Decreased central vision (HP:0007663)2.03062979
106Hypothermia (HP:0002045)2.02671843
107Osteomalacia (HP:0002749)2.00571094
108Abnormality of the gallbladder (HP:0005264)2.00201937
109Hemorrhage of the eye (HP:0011885)1.98654641
110Rickets (HP:0002748)1.94333812
1113-Methylglutaconic aciduria (HP:0003535)1.93749275
112Abnormality of iron homeostasis (HP:0011031)1.92219233
113Abnormal cartilage morphology (HP:0002763)1.91051469
114Renal cortical cysts (HP:0000803)1.90235120
115Abnormality of transition element cation homeostasis (HP:0011030)1.89560484
116Alkalosis (HP:0001948)1.87880599
117Abolished electroretinogram (ERG) (HP:0000550)1.87869283
118Abnormality of the renal medulla (HP:0100957)1.85527680
119Status epilepticus (HP:0002133)1.84889650
120Elevated hepatic transaminases (HP:0002910)1.84301976
121Hydroxyprolinuria (HP:0003080)1.84035373
122Abnormality of proline metabolism (HP:0010907)1.84035373
123Abnormal enzyme/coenzyme activity (HP:0012379)1.82098615
124Methylmalonic acidemia (HP:0002912)1.81524791
125Hypophosphatemic rickets (HP:0004912)1.80254377
126Acute encephalopathy (HP:0006846)1.80141155
127Attenuation of retinal blood vessels (HP:0007843)1.80004561
128Abnormal rod and cone electroretinograms (HP:0008323)1.78614995
129Increased corneal curvature (HP:0100692)1.78489333
130Keratoconus (HP:0000563)1.78489333
131Large for gestational age (HP:0001520)1.78161422
132Nephritis (HP:0000123)1.76822905
133Decreased electroretinogram (ERG) amplitude (HP:0000654)1.75424495
134Hyperventilation (HP:0002883)1.72735985
135Cerebral palsy (HP:0100021)1.72103367
136Hyperglycemia (HP:0003074)1.71741694
137Reduced antithrombin III activity (HP:0001976)1.71311439
138Proximal tubulopathy (HP:0000114)1.69672039
139Blue irides (HP:0000635)1.67595295
140* Abnormality of vitamin metabolism (HP:0100508)1.65606037
141Pulmonary embolism (HP:0002204)1.56776655
142Methylmalonic aciduria (HP:0012120)1.56287338
143Cystic liver disease (HP:0006706)1.55126604
144Joint swelling (HP:0001386)1.53631004

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.28034962
2SIK14.56321965
3FGFR44.45341065
4ERN14.23566081
5WNK33.08580862
6ADRBK23.00733418
7INSRR2.98688646
8TAOK32.97308539
9ERBB42.89007285
10ZAK2.51262300
11PKN22.44972773
12BMPR1B2.42274919
13MAP2K42.37103875
14NUAK12.34881054
15CASK2.34398479
16MAP4K22.25893408
17MST1R2.16868286
18FLT32.08521864
19CAMKK21.90303181
20TNIK1.90259977
21MAPK111.88222566
22AKT31.87518637
23PIK3CG1.84683168
24MAPK131.83716024
25LATS11.81284052
26TRIB31.80307064
27PNCK1.77043156
28WNK41.69066439
29TXK1.68524997
30TYK21.66148003
31TAF11.62236427
32FRK1.60168046
33FGFR21.53343779
34ACVR1B1.52822365
35ABL21.50360066
36PTK61.48319294
37PAK31.48278323
38DAPK21.44721789
39NEK91.44043861
40TLK11.42949128
41MAP3K41.42809521
42MARK11.36293029
43DYRK21.32895606
44MUSK1.31018612
45KDR1.30412302
46NTRK31.25192087
47MAP3K71.22582358
48PINK11.21225298
49JAK21.20975333
50TRIM281.16768563
51OXSR11.14834792
52PRKAA21.14664753
53NLK1.14490323
54MAP3K101.04743415
55MAP2K31.04080533
56PRKCE1.03902418
57GRK61.03757984
58MAPK41.02355884
59TBK11.01138973
60ERBB21.00067247
61JAK10.96387162
62MAP3K140.94786297
63NEK20.93406095
64PRKCZ0.91329209
65WEE10.90185136
66STK38L0.87573062
67MET0.87011245
68CDK60.86143266
69ADRBK10.86061718
70MAP3K30.83719950
71STK390.81236477
72LIMK10.80841459
73FER0.80569226
74CAMK1D0.80449709
75MAPK120.80093285
76BRSK20.79880987
77MARK30.79661972
78EPHB10.78336689
79TIE10.76453520
80EPHA30.76299573
81PRKACG0.75677638
82BCR0.75208726
83IRAK40.74780140
84CCNB10.73756287
85ERBB30.73697505
86MKNK20.73113645
87PRKACA0.72834636
88MAP3K110.72100456
89MAPK150.70061851
90MAP2K60.68702590
91CAMK2G0.68124935
92RIPK10.66240214
93SGK30.66178171
94DYRK1B0.66149096
95CSK0.66012138
96FGFR30.65530622
97GSK3A0.65169467
98PLK20.65151615
99PRKAA10.64797417
100TGFBR20.63321409
101CSF1R0.62707718
102PRKCI0.61826952
103CAMK2A0.60720852
104MAP2K70.59790134
105IRAK30.59123549
106MAPK70.59086987
107GRK70.57884364
108TNK20.54614740
109PRKG10.53397103
110MAPKAPK30.51415308
111PRKCQ0.50395791
112PTK20.50256202
113SGK20.49971129
114VRK10.49666693
115EPHA40.49257990
116CSNK1G10.49060540
117IKBKE0.48189180
118PDPK10.48016989
119CAMK10.47710024
120MAPKAPK50.47167220
121IGF1R0.46824791
122MAP3K50.46790182
123STK110.46533329
124TAOK20.46339262
125GRK10.45158977
126RET0.44787564
127GRK50.44386801
128CDK40.42815596
129CSNK1D0.42783690
130RPS6KA50.41547329
131MAP3K60.40572173
132CSNK1A10.40467008
133PHKG20.39873230
134PHKG10.39873230
135MAP2K10.39853026
136CSNK1E0.39833906
137DYRK1A0.38825931
138PDK30.38575668
139PDK40.38575668
140PRKCG0.37904147
141MAP3K130.36893377
142TGFBR10.35117410
143PBK0.34872791
144MTOR0.34214037
145CAMK2B0.34135142
146EGFR0.33370593
147SGK4940.32756860
148SGK2230.32756860
149ICK0.32657335
150PDK10.32416047
151IRAK10.29863478
152CAMK40.29428442
153PKN10.29051651
154LATS20.29043473
155CSNK1G20.27723504
156IRAK20.27636246
157CAMK1G0.27009879
158PRKCA0.25211504
159PIK3CA0.24143017
160CSNK1G30.23649300
161ABL10.23368511
162MAP3K10.21015132
163BMX0.19212241

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.49504220
2Nitrogen metabolism_Homo sapiens_hsa009103.77999941
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.42101178
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.38607966
5Arginine biosynthesis_Homo sapiens_hsa002203.10211945
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.72886209
7Complement and coagulation cascades_Homo sapiens_hsa046102.72312380
8Tryptophan metabolism_Homo sapiens_hsa003802.67388753
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58793224
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53325824
11Fatty acid degradation_Homo sapiens_hsa000712.49281559
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37559893
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26159873
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14344537
15Butanoate metabolism_Homo sapiens_hsa006502.12615374
16Peroxisome_Homo sapiens_hsa041462.07475053
17Chemical carcinogenesis_Homo sapiens_hsa052041.95751600
18Propanoate metabolism_Homo sapiens_hsa006401.94605776
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93799931
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93633990
21Histidine metabolism_Homo sapiens_hsa003401.87462673
22PPAR signaling pathway_Homo sapiens_hsa033201.86781721
23Caffeine metabolism_Homo sapiens_hsa002321.82158245
24Fatty acid metabolism_Homo sapiens_hsa012121.81193187
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.78912079
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.78090614
27Staphylococcus aureus infection_Homo sapiens_hsa051501.72682028
28beta-Alanine metabolism_Homo sapiens_hsa004101.71609729
29Retinol metabolism_Homo sapiens_hsa008301.70558963
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68055833
31Selenocompound metabolism_Homo sapiens_hsa004501.58109670
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56346648
33Phenylalanine metabolism_Homo sapiens_hsa003601.56172940
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51536859
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49347429
36Bile secretion_Homo sapiens_hsa049761.48623217
37Tyrosine metabolism_Homo sapiens_hsa003501.41495255
38Pyruvate metabolism_Homo sapiens_hsa006201.35851989
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35473173
40Fatty acid elongation_Homo sapiens_hsa000621.32692022
41Sulfur metabolism_Homo sapiens_hsa009201.31355358
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27801307
43Biosynthesis of amino acids_Homo sapiens_hsa012301.22841377
44Folate biosynthesis_Homo sapiens_hsa007901.19380825
45ABC transporters_Homo sapiens_hsa020101.18756429
46Steroid biosynthesis_Homo sapiens_hsa001001.16678840
47Fat digestion and absorption_Homo sapiens_hsa049751.15134298
48Carbon metabolism_Homo sapiens_hsa012001.13411423
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02474131
50Cyanoamino acid metabolism_Homo sapiens_hsa004600.97208800
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96633259
52Arginine and proline metabolism_Homo sapiens_hsa003300.95464688
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.95162812
54Vitamin B6 metabolism_Homo sapiens_hsa007500.90492123
55Sulfur relay system_Homo sapiens_hsa041220.90184682
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86817189
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86680785
58Vitamin digestion and absorption_Homo sapiens_hsa049770.84787970
59Lysine degradation_Homo sapiens_hsa003100.81155117
60One carbon pool by folate_Homo sapiens_hsa006700.75521933
61Phototransduction_Homo sapiens_hsa047440.75447949
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69985076
63Glycerolipid metabolism_Homo sapiens_hsa005610.67690978
64Glutathione metabolism_Homo sapiens_hsa004800.64931332
65Pentose phosphate pathway_Homo sapiens_hsa000300.59151650
66Fatty acid biosynthesis_Homo sapiens_hsa000610.58772887
67Nicotine addiction_Homo sapiens_hsa050330.54175865
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51785803
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49211477
70Metabolic pathways_Homo sapiens_hsa011000.45844606
71Oxidative phosphorylation_Homo sapiens_hsa001900.45346251
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44991313
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36690452
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34593605
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34317487
76Serotonergic synapse_Homo sapiens_hsa047260.33588865
77Prion diseases_Homo sapiens_hsa050200.31615282
78Ether lipid metabolism_Homo sapiens_hsa005650.26427564
79Parkinsons disease_Homo sapiens_hsa050120.26373545
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25340349
81Galactose metabolism_Homo sapiens_hsa000520.24786027
82Fructose and mannose metabolism_Homo sapiens_hsa000510.23034714
83Linoleic acid metabolism_Homo sapiens_hsa005910.22705467
84Insulin resistance_Homo sapiens_hsa049310.22330540
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.22166899
86Protein export_Homo sapiens_hsa030600.21343242
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17288308
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.15085638
89Homologous recombination_Homo sapiens_hsa034400.12555542
90GABAergic synapse_Homo sapiens_hsa047270.12491981
91Olfactory transduction_Homo sapiens_hsa047400.11857162
92Taste transduction_Homo sapiens_hsa047420.11317793
93Mineral absorption_Homo sapiens_hsa049780.10730148
94Glucagon signaling pathway_Homo sapiens_hsa049220.09610666
95Basal transcription factors_Homo sapiens_hsa030220.07307928
96Morphine addiction_Homo sapiens_hsa050320.06360860
97RNA polymerase_Homo sapiens_hsa030200.05281610
98Fanconi anemia pathway_Homo sapiens_hsa034600.04701695
99Insulin secretion_Homo sapiens_hsa049110.04663220
100Alzheimers disease_Homo sapiens_hsa050100.02764768
101Pertussis_Homo sapiens_hsa051330.02201249
102AMPK signaling pathway_Homo sapiens_hsa041520.01909159
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.2537770
104Amoebiasis_Homo sapiens_hsa05146-0.2505568
105Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2423106
106Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2377501
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2225863
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2012704
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2000938
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1922556
111Renin-angiotensin system_Homo sapiens_hsa04614-0.1869727
112Hepatitis C_Homo sapiens_hsa05160-0.1867943
113Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1681927
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1640363
115African trypanosomiasis_Homo sapiens_hsa05143-0.1531940
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1520743
117Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1519745
118Regulation of autophagy_Homo sapiens_hsa04140-0.1444115
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1073208
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0994116
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0794395
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0750085
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0598029

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »