TTR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.53962473
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.53962473
3L-phenylalanine metabolic process (GO:0006558)7.09113878
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.09113878
5aromatic amino acid family catabolic process (GO:0009074)6.14805934
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.81472542
7negative regulation of execution phase of apoptosis (GO:1900118)5.24447815
8alpha-linolenic acid metabolic process (GO:0036109)5.19898342
9high-density lipoprotein particle remodeling (GO:0034375)5.11172087
10bile acid biosynthetic process (GO:0006699)5.03798648
11tryptophan catabolic process (GO:0006569)4.93661393
12indole-containing compound catabolic process (GO:0042436)4.93661393
13indolalkylamine catabolic process (GO:0046218)4.93661393
14kynurenine metabolic process (GO:0070189)4.90341377
15positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.90143782
16peptidyl-glutamic acid carboxylation (GO:0017187)4.88206473
17protein carboxylation (GO:0018214)4.88206473
18tryptophan metabolic process (GO:0006568)4.87438306
19negative regulation of fibrinolysis (GO:0051918)4.85946510
20urea metabolic process (GO:0019627)4.85560482
21urea cycle (GO:0000050)4.85560482
22complement activation, alternative pathway (GO:0006957)4.78386078
23glyoxylate metabolic process (GO:0046487)4.75583036
24reverse cholesterol transport (GO:0043691)4.74416661
25tyrosine metabolic process (GO:0006570)4.72642565
26regulation of protein activation cascade (GO:2000257)4.69822710
27regulation of fibrinolysis (GO:0051917)4.67117065
28sulfur amino acid catabolic process (GO:0000098)4.61666577
29regulation of cholesterol esterification (GO:0010872)4.59015549
30glycerophospholipid catabolic process (GO:0046475)4.50453850
31aromatic amino acid family metabolic process (GO:0009072)4.48435049
32bile acid metabolic process (GO:0008206)4.48364785
33nitrogen cycle metabolic process (GO:0071941)4.46484618
34phospholipid efflux (GO:0033700)4.40153593
35regulation of complement activation (GO:0030449)4.40100764
36cysteine metabolic process (GO:0006534)4.39244401
37protein-lipid complex remodeling (GO:0034368)4.39184723
38macromolecular complex remodeling (GO:0034367)4.39184723
39plasma lipoprotein particle remodeling (GO:0034369)4.39184723
40epithelial cell fate commitment (GO:0072148)4.27484181
41fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.22911749
42serine family amino acid catabolic process (GO:0009071)4.22165872
43insulin secretion (GO:0030073)4.17509404
44regulation of triglyceride catabolic process (GO:0010896)4.17298539
45acylglycerol homeostasis (GO:0055090)4.10032507
46triglyceride homeostasis (GO:0070328)4.10032507
47peptide hormone processing (GO:0016486)4.07975877
48positive regulation of gluconeogenesis (GO:0045722)4.05927502
49cellular ketone body metabolic process (GO:0046950)4.02159513
50bile acid and bile salt transport (GO:0015721)4.01780284
51cholesterol efflux (GO:0033344)4.01513577
52alpha-amino acid catabolic process (GO:1901606)4.00398573
53negative regulation of sterol transport (GO:0032372)3.96863742
54negative regulation of cholesterol transport (GO:0032375)3.96863742
55regulation of type B pancreatic cell apoptotic process (GO:2000674)3.96690196
56endocrine pancreas development (GO:0031018)3.95331021
57plasma lipoprotein particle clearance (GO:0034381)3.88817781
58inositol phosphate catabolic process (GO:0071545)3.86315510
59lysine metabolic process (GO:0006553)3.85672500
60lysine catabolic process (GO:0006554)3.85672500
61auditory receptor cell differentiation (GO:0042491)3.84638494
62plasma lipoprotein particle assembly (GO:0034377)3.82560655
63positive regulation of histone H3-K4 methylation (GO:0051571)3.82300401
64positive regulation of insulin secretion (GO:0032024)3.80108392
65glutamate metabolic process (GO:0006536)3.79041487
66homocysteine metabolic process (GO:0050667)3.78945605
67amino-acid betaine metabolic process (GO:0006577)3.78678949
68cellular amino acid catabolic process (GO:0009063)3.74064136
69dicarboxylic acid biosynthetic process (GO:0043650)3.73125817
70cellular modified amino acid catabolic process (GO:0042219)3.72620516
71indolalkylamine metabolic process (GO:0006586)3.69040647
72inositol phosphate dephosphorylation (GO:0046855)3.66877693
73phosphorylated carbohydrate dephosphorylation (GO:0046838)3.66877693
74low-density lipoprotein particle remodeling (GO:0034374)3.65274033
75respiratory chain complex IV assembly (GO:0008535)3.65207063
76coenzyme catabolic process (GO:0009109)3.64062639
77complement activation, classical pathway (GO:0006958)3.59414517
78negative regulation of lipase activity (GO:0060192)3.50999127
79regulation of cholesterol homeostasis (GO:2000188)3.50936793
80L-alpha-amino acid transmembrane transport (GO:1902475)3.49493029
81protein-lipid complex assembly (GO:0065005)3.49474413
82ketone body metabolic process (GO:1902224)3.48015723
83cytochrome complex assembly (GO:0017004)3.47984102
84phospholipid homeostasis (GO:0055091)3.47751714
85negative regulation of cytosolic calcium ion concentration (GO:0051481)3.46244202
86water-soluble vitamin biosynthetic process (GO:0042364)3.44907304
87imidazole-containing compound metabolic process (GO:0052803)3.44749871
88regulation of extracellular matrix disassembly (GO:0010715)3.43313896
89plasma lipoprotein particle organization (GO:0071827)3.42780087
90nitric oxide biosynthetic process (GO:0006809)3.41979071
91complement activation (GO:0006956)3.38855234
92negative regulation of digestive system process (GO:0060457)3.38409396
93cellular biogenic amine catabolic process (GO:0042402)3.37084263
94amine catabolic process (GO:0009310)3.37084263
95regulation of bile acid biosynthetic process (GO:0070857)3.36044101
96benzene-containing compound metabolic process (GO:0042537)3.35396462
97polyol catabolic process (GO:0046174)3.34811681
98cytolysis (GO:0019835)3.33889920
99fibrinolysis (GO:0042730)3.33557383
100regulation of glucokinase activity (GO:0033131)3.32782745
101regulation of hexokinase activity (GO:1903299)3.32782745
102macroautophagy (GO:0016236)3.32408931
103positive regulation of lipid catabolic process (GO:0050996)3.32157785
104negative regulation of protein activation cascade (GO:2000258)3.31249080
105cellular glucuronidation (GO:0052695)3.31095693
106intestinal cholesterol absorption (GO:0030299)3.30850196
107carboxylic acid catabolic process (GO:0046395)3.30083866
108organic acid catabolic process (GO:0016054)3.30083866
109phenylpropanoid metabolic process (GO:0009698)3.28500907
110short-chain fatty acid metabolic process (GO:0046459)3.28382674
111cholesterol homeostasis (GO:0042632)3.28048269
112detection of calcium ion (GO:0005513)3.27878807
113positive regulation of peptide hormone secretion (GO:0090277)3.27266376
114drug catabolic process (GO:0042737)3.26797254
115very-low-density lipoprotein particle assembly (GO:0034379)3.26424955
116protein-lipid complex subunit organization (GO:0071825)3.26135209
117glandular epithelial cell differentiation (GO:0002067)3.25567938
118positive regulation of calcium ion import (GO:0090280)3.25217043
119protein activation cascade (GO:0072376)3.24981741
120regulation of execution phase of apoptosis (GO:1900117)3.24221552
121lipoprotein metabolic process (GO:0042157)3.23671464
122sterol homeostasis (GO:0055092)3.22395773
123aldehyde catabolic process (GO:0046185)3.22189988
124glycine metabolic process (GO:0006544)3.21603189
125arginine metabolic process (GO:0006525)3.20066034
126monocarboxylic acid catabolic process (GO:0072329)3.14708004
127positive regulation of peptide secretion (GO:0002793)3.14144092
128blood coagulation, intrinsic pathway (GO:0007597)3.13521445
129cofactor catabolic process (GO:0051187)3.13445460
130positive regulation of lipoprotein lipase activity (GO:0051006)3.12537378
131positive regulation of triglyceride lipase activity (GO:0061365)3.12537378
132serine family amino acid metabolic process (GO:0009069)3.10780208
133signal peptide processing (GO:0006465)2.98708656
134lactate metabolic process (GO:0006089)2.96576604
135regulation of neurotransmitter uptake (GO:0051580)2.90384110
136epithelial cilium movement (GO:0003351)2.86917395
137pteridine-containing compound biosynthetic process (GO:0042559)2.85297667
138negative regulation of complement activation (GO:0045916)2.85076628
139axoneme assembly (GO:0035082)2.81961591
140nephron epithelium morphogenesis (GO:0072088)2.80504593
141nephron tubule morphogenesis (GO:0072078)2.80504593
142peptide hormone secretion (GO:0030072)2.79497383
143xenobiotic catabolic process (GO:0042178)2.78514152
144nodal signaling pathway (GO:0038092)2.77525844
145S-adenosylmethionine metabolic process (GO:0046500)2.76959179
146nitric oxide mediated signal transduction (GO:0007263)2.73964440
147regulation of insulin secretion (GO:0050796)2.73765177
148positive regulation of meiosis (GO:0045836)2.73594390
149peptide secretion (GO:0002790)2.72898492
150zinc ion homeostasis (GO:0055069)2.72660320
151alanine transport (GO:0032328)2.71672025
152zinc ion transmembrane transport (GO:0071577)2.71510549
153positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.68367259
154regulation of autophagic vacuole assembly (GO:2000785)2.67906984
155protein complex biogenesis (GO:0070271)2.67712056
156positive regulation of macroautophagy (GO:0016239)2.65287848
157phospholipid catabolic process (GO:0009395)2.64393304
158regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.63111897
159proline transport (GO:0015824)2.63018757
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.61516244
161sphingomyelin metabolic process (GO:0006684)2.57413138
162potassium ion export (GO:0071435)2.56868726
163renal tubule morphogenesis (GO:0061333)2.55260953
164regulation of peptide hormone secretion (GO:0090276)2.54298815
165positive regulation of glycolytic process (GO:0045821)2.54189865
166regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.53990096
167positive regulation of meiotic cell cycle (GO:0051446)2.52569125
168zinc ion transport (GO:0006829)2.51024770
169dendritic spine morphogenesis (GO:0060997)2.49791175
170regulation of acrosome reaction (GO:0060046)2.48216180
171regulation of peptide secretion (GO:0002791)2.47811704
172positive regulation of response to extracellular stimulus (GO:0032106)2.44690777
173positive regulation of response to nutrient levels (GO:0032109)2.44690777
174somite rostral/caudal axis specification (GO:0032525)2.44473196
175negative regulation of hormone biosynthetic process (GO:0032353)2.44263730
176C-terminal protein lipidation (GO:0006501)2.43877138
177astrocyte differentiation (GO:0048708)2.43654886
178positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42386628
179dentate gyrus development (GO:0021542)2.40813475
180heme transport (GO:0015886)2.40673553
181regulation of vacuole organization (GO:0044088)2.40407462
182peptide transport (GO:0015833)2.39964878
183purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.39851684
1843-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.39851684
185cilium movement (GO:0003341)2.38581820
186positive regulation of hormone secretion (GO:0046887)2.38567751
187cellular zinc ion homeostasis (GO:0006882)2.37967425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.25312743
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.23885490
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.84765976
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.45838297
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.80889895
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.28884279
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.96323345
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66208533
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.38917681
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34428190
11GBX2_23144817_ChIP-Seq_PC3_Human2.85403014
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40411541
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33986335
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31029387
15ZNF274_21170338_ChIP-Seq_K562_Hela2.06646605
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.06020251
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.0975692
18GATA1_22025678_ChIP-Seq_K562_Human1.96173020
19IGF1R_20145208_ChIP-Seq_DFB_Human1.95792396
20FOXA2_19822575_ChIP-Seq_HepG2_Human1.85006483
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80334519
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79141398
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71333024
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68783033
25SMAD4_21799915_ChIP-Seq_A2780_Human1.65739706
26P300_19829295_ChIP-Seq_ESCs_Human1.64778518
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62112796
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60496106
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58645896
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57784528
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.55504955
32* FUS_26573619_Chip-Seq_HEK293_Human1.52595187
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50960074
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48846069
35TAF15_26573619_Chip-Seq_HEK293_Human1.48244952
36STAT3_23295773_ChIP-Seq_U87_Human1.45550541
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.45428030
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44548271
39EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44396987
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.44240153
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.43810551
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.43172170
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42936019
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41983038
45CLOCK_20551151_ChIP-Seq_293T_Human1.40943420
46ER_23166858_ChIP-Seq_MCF-7_Human1.40043143
47* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38706931
48AR_25329375_ChIP-Seq_VCAP_Human1.38384481
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35433467
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34255952
51P53_22387025_ChIP-Seq_ESCs_Mouse1.33243196
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.33190137
53TCF4_23295773_ChIP-Seq_U87_Human1.32634072
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.31634934
55VDR_22108803_ChIP-Seq_LS180_Human1.31119934
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30806341
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.30787462
58* HNF4A_19822575_ChIP-Seq_HepG2_Human1.30014226
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29950198
60FOXA1_25329375_ChIP-Seq_VCAP_Human1.29622064
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29622064
62STAT3_18555785_Chip-Seq_ESCs_Mouse1.29583664
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.26818418
64CDX2_22108803_ChIP-Seq_LS180_Human1.25499793
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.23645837
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.23562506
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.22913399
68E2F1_18555785_Chip-Seq_ESCs_Mouse1.22899295
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22490268
70* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22466567
71TP53_22573176_ChIP-Seq_HFKS_Human1.21582841
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18470692
73SOX2_19829295_ChIP-Seq_ESCs_Human1.17498509
74NANOG_19829295_ChIP-Seq_ESCs_Human1.17498509
75* HTT_18923047_ChIP-ChIP_STHdh_Human1.13414531
76NMYC_18555785_Chip-Seq_ESCs_Mouse1.12140487
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11947148
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.11224674
79EWS_26573619_Chip-Seq_HEK293_Human1.10519446
80P300_18555785_Chip-Seq_ESCs_Mouse1.10326703
81CBP_20019798_ChIP-Seq_JUKART_Human1.10232172
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10232172
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08423711
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.08090601
85OCT4_18555785_Chip-Seq_ESCs_Mouse1.06609113
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06528851
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06179179
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05294904
89RUNX2_22187159_ChIP-Seq_PCA_Human1.04753380
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03438673
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02764410
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01503733
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01351574
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.01278582
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00092988
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99333010
97TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99184976
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99127971
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98964282
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.98767921
101CRX_20693478_ChIP-Seq_RETINA_Mouse0.98640267
102FOXA1_25552417_ChIP-Seq_VCAP_Human0.98465676
103SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98139871
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.97926812
105RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96542624
106FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93369038
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92423799
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88206376
109NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87241598
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86285388
111STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85817117
112GATA1_19941826_ChIP-Seq_K562_Human0.80954607
113* GATA4_25053715_ChIP-Seq_YYC3_Human0.80422013
114ESR2_21235772_ChIP-Seq_MCF-7_Human0.80361363
115IRF8_22096565_ChIP-ChIP_GC-B_Human0.79726735
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78025162
117ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78020528
118LXR_22292898_ChIP-Seq_THP-1_Human0.77576420
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.76444050
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76321255
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.74159597
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.71919510
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.70336603
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.69507473
125BCAT_22108803_ChIP-Seq_LS180_Human0.67807504
126* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66606735
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66080383
128NFIB_24661679_ChIP-Seq_LUNG_Mouse0.65405391
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.65307947
130NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64744428
131NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64744428
132ESR1_21235772_ChIP-Seq_MCF-7_Human0.63004533
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.62949811
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.62900469
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.62846316
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.61968817
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.61744902
138TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60822801
139AR_20517297_ChIP-Seq_VCAP_Human0.60788921
140SOX2_20726797_ChIP-Seq_SW620_Human0.59036458
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.58915615
142RARG_19884340_ChIP-ChIP_MEFs_Mouse0.58686320
143P53_21459846_ChIP-Seq_SAOS-2_Human0.57767665
144GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.56705343
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.55027449
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53487427
147PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53424830
148REST_21632747_ChIP-Seq_MESCs_Mouse0.53270820
149FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52693805
150CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.52439738
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.52047630
152KLF4_19829295_ChIP-Seq_ESCs_Human0.51926991
153SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51837351
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.51767406
155DROSHA_22980978_ChIP-Seq_HELA_Human0.51546929
156CBP_21632823_ChIP-Seq_H3396_Human0.50923227
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.50141828
158SOX2_21211035_ChIP-Seq_LN229_Gbm0.49454308
159BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.49361410
160RAD21_21589869_ChIP-Seq_MESCs_Mouse0.49012209
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.48768570
162EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.48711921
163GATA2_19941826_ChIP-Seq_K562_Human0.47055225
164ERG_20517297_ChIP-Seq_VCAP_Human0.46631075
165MYC_19915707_ChIP-ChIP_AK7_Human0.46221364
166ERG_21242973_ChIP-ChIP_JURKAT_Human0.45973316
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.44981546
168FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.43427713
169FOXH1_21741376_ChIP-Seq_ESCs_Human0.43146594
170MTF2_20144788_ChIP-Seq_MESCs_Mouse0.42507303
171GATA3_24758297_ChIP-Seq_MCF-7_Human0.41807719
172P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.41325147
173SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.41233731
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.40510667
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.40510667
176TCF4_22108803_ChIP-Seq_LS180_Human0.40020770

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.23359056
2MP0005360_urolithiasis6.11120754
3MP0005365_abnormal_bile_salt5.77555658
4MP0005085_abnormal_gallbladder_physiolo5.57261862
5MP0008875_abnormal_xenobiotic_pharmacok4.21614449
6MP0003252_abnormal_bile_duct3.90273303
7MP0003195_calcinosis3.85015102
8MP0003806_abnormal_nucleotide_metabolis3.34610581
9MP0009840_abnormal_foam_cell3.27732796
10MP0010329_abnormal_lipoprotein_level3.24193705
11MP0002163_abnormal_gland_morphology3.08208437
12MP0005332_abnormal_amino_acid2.71003247
13MP0010234_abnormal_vibrissa_follicle2.50999611
14MP0005083_abnormal_biliary_tract2.47669225
15MP0003787_abnormal_imprinting2.45735263
16MP0000013_abnormal_adipose_tissue2.41867036
17MP0003191_abnormal_cellular_cholesterol2.37125407
18* MP0004019_abnormal_vitamin_homeostasis2.33058564
19MP0001666_abnormal_nutrient_absorption2.25777120
20MP0002138_abnormal_hepatobiliary_system2.11710552
21MP0003011_delayed_dark_adaptation2.09845435
22MP0006072_abnormal_retinal_apoptosis2.06991841
23MP0003122_maternal_imprinting2.06372981
24MP0002118_abnormal_lipid_homeostasis2.01640542
25MP0009046_muscle_twitch1.90632388
26MP0000609_abnormal_liver_physiology1.90567957
27MP0008877_abnormal_DNA_methylation1.87047141
28MP0003183_abnormal_peptide_metabolism1.77363677
29MP0003868_abnormal_feces_composition1.76716670
30MP0001764_abnormal_homeostasis1.73396177
31MP0005551_abnormal_eye_electrophysiolog1.58991842
32MP0005379_endocrine/exocrine_gland_phen1.58701429
33MP0001984_abnormal_olfaction1.50844700
34MP0003283_abnormal_digestive_organ1.48366668
35MP0005319_abnormal_enzyme/_coenzyme1.48281426
36MP0002837_dystrophic_cardiac_calcinosis1.46733212
37MP0005220_abnormal_exocrine_pancreas1.46452426
38MP0009643_abnormal_urine_homeostasis1.43468504
39MP0001944_abnormal_pancreas_morphology1.42226093
40MP0005584_abnormal_enzyme/coenzyme_acti1.41931491
41MP0002078_abnormal_glucose_homeostasis1.41852949
42MP0001501_abnormal_sleep_pattern1.38897373
43MP0005253_abnormal_eye_physiology1.37940683
44MP0005084_abnormal_gallbladder_morpholo1.36718711
45MP0002909_abnormal_adrenal_gland1.34512989
46MP0002638_abnormal_pupillary_reflex1.33250123
47MP0008004_abnormal_stomach_pH1.32383423
48MP0001756_abnormal_urination1.26516186
49MP0004133_heterotaxia1.26344188
50MP0009745_abnormal_behavioral_response1.24593060
51MP0000003_abnormal_adipose_tissue1.22659118
52MP0009697_abnormal_copulation1.20853946
53MP0002938_white_spotting1.20529463
54MP0005058_abnormal_lysosome_morphology1.19081241
55MP0002928_abnormal_bile_duct1.17985181
56MP0000372_irregular_coat_pigmentation1.17158517
57MP0000631_abnormal_neuroendocrine_gland1.16934912
58MP0005636_abnormal_mineral_homeostasis1.16760670
59MP0005174_abnormal_tail_pigmentation1.15679758
60MP0004043_abnormal_pH_regulation1.09883602
61MP0002693_abnormal_pancreas_physiology1.07411030
62MP0005535_abnormal_body_temperature1.07165882
63MP0004885_abnormal_endolymph1.05520759
64MP0000604_amyloidosis1.04624066
65MP0002064_seizures1.03901742
66MP0005645_abnormal_hypothalamus_physiol1.03810883
67MP0003879_abnormal_hair_cell1.03726175
68MP0002971_abnormal_brown_adipose1.03073027
69MP0005408_hypopigmentation1.00893734
70MP0005248_abnormal_Harderian_gland1.00816226
71MP0002734_abnormal_mechanical_nocicepti1.00445936
72MP0005670_abnormal_white_adipose0.98963192
73MP0002272_abnormal_nervous_system0.98579232
74MP0003186_abnormal_redox_activity0.97462825
75MP0003172_abnormal_lysosome_physiology0.97406346
76MP0006054_spinal_hemorrhage0.97196811
77MP0000639_abnormal_adrenal_gland0.97004047
78MP0001905_abnormal_dopamine_level0.96742257
79MP0000598_abnormal_liver_morphology0.96187976
80MP0000569_abnormal_digit_pigmentation0.94452025
81MP0000427_abnormal_hair_cycle0.94114370
82MP0005375_adipose_tissue_phenotype0.92344595
83MP0003121_genomic_imprinting0.92323829
84MP0003656_abnormal_erythrocyte_physiolo0.91788791
85MP0002557_abnormal_social/conspecific_i0.91672489
86* MP0009642_abnormal_blood_homeostasis0.90907068
87MP0001970_abnormal_pain_threshold0.90583965
88MP0003690_abnormal_glial_cell0.89842805
89MP0000516_abnormal_urinary_system0.89464876
90MP0005367_renal/urinary_system_phenotyp0.89464876
91MP0001765_abnormal_ion_homeostasis0.89361882
92MP0008961_abnormal_basal_metabolism0.86397741
93MP0010678_abnormal_skin_adnexa0.86080161
94MP0009780_abnormal_chondrocyte_physiolo0.85301263
95MP0001986_abnormal_taste_sensitivity0.83759758
96MP0004142_abnormal_muscle_tone0.83656981
97* MP0003953_abnormal_hormone_level0.83597700
98MP0005334_abnormal_fat_pad0.82434282
99MP0000538_abnormal_urinary_bladder0.82181560
100MP0005666_abnormal_adipose_tissue0.81803432
101MP0000015_abnormal_ear_pigmentation0.81571908
102MP0005448_abnormal_energy_balance0.79979608
103MP0004215_abnormal_myocardial_fiber0.79237371
104MP0002229_neurodegeneration0.79089900
105MP0002733_abnormal_thermal_nociception0.78760006
106MP0003329_amyloid_beta_deposits0.77929213
107MP0002295_abnormal_pulmonary_circulatio0.77913519
108MP0004924_abnormal_behavior0.77904031
109MP0005386_behavior/neurological_phenoty0.77904031
110MP0004130_abnormal_muscle_cell0.77047325
111MP0009763_increased_sensitivity_to0.76458144
112MP0001968_abnormal_touch/_nociception0.76270298
113MP0010368_abnormal_lymphatic_system0.75527966
114MP0003123_paternal_imprinting0.75434418
115MP0001661_extended_life_span0.74744589
116* MP0008469_abnormal_protein_level0.74149587
117MP0003633_abnormal_nervous_system0.73011204
118MP0004085_abnormal_heartbeat0.72831644
119MP0002168_other_aberrant_phenotype0.72515496
120MP0005647_abnormal_sex_gland0.69713867
121MP0005451_abnormal_body_composition0.69474986
122MP0006036_abnormal_mitochondrial_physio0.67340924
123MP0003959_abnormal_lean_body0.65248985
124MP0003300_gastrointestinal_ulcer0.64930026
125MP0002090_abnormal_vision0.64438855
126MP0002876_abnormal_thyroid_physiology0.62009824
127MP0005376_homeostasis/metabolism_phenot0.61779866
128MP0000230_abnormal_systemic_arterial0.60017621
129MP0003638_abnormal_response/metabolism_0.56845528
130MP0002254_reproductive_system_inflammat0.54579778
131MP0004264_abnormal_extraembryonic_tissu0.54235586
132MP0009764_decreased_sensitivity_to0.52588917
133MP0003075_altered_response_to0.52244178
134MP0010386_abnormal_urinary_bladder0.50166747
135MP0001502_abnormal_circadian_rhythm0.50059335
136MP0009765_abnormal_xenobiotic_induced0.49498423
137MP0002136_abnormal_kidney_physiology0.48239947
138MP0006082_CNS_inflammation0.46735159
139MP0002069_abnormal_eating/drinking_beha0.43591972
140MP0005395_other_phenotype0.43352351
141MP0009672_abnormal_birth_weight0.42961158
142MP0002970_abnormal_white_adipose0.42643294
143MP0005266_abnormal_metabolism0.42485528
144MP0003631_nervous_system_phenotype0.42315565
145MP0005646_abnormal_pituitary_gland0.41691079
146MP0004270_analgesia0.41122908
147MP0005075_abnormal_melanosome_morpholog0.40699649
148MP0003705_abnormal_hypodermis_morpholog0.38703182
149MP0002877_abnormal_melanocyte_morpholog0.38649105

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.27081502
2Deep venous thrombosis (HP:0002625)6.09373574
3Intrahepatic cholestasis (HP:0001406)5.94957378
4Prolonged partial thromboplastin time (HP:0003645)5.50448833
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.44837714
6Complement deficiency (HP:0004431)5.36260048
7Hypoglycemic coma (HP:0001325)5.33916370
8Xanthomatosis (HP:0000991)5.31388801
9Hypobetalipoproteinemia (HP:0003563)5.07521393
10Hyperlipoproteinemia (HP:0010980)4.77941973
11Ketosis (HP:0001946)4.55721596
12Hypoglycemic seizures (HP:0002173)4.43679809
13Ketoacidosis (HP:0001993)4.40377996
14Hyperinsulinemic hypoglycemia (HP:0000825)4.29417637
15Hypolipoproteinemia (HP:0010981)4.27024321
16Hypoalphalipoproteinemia (HP:0003233)4.14932792
17Abnormality of the common coagulation pathway (HP:0010990)4.05173243
18Intestinal atresia (HP:0011100)3.94407060
19Joint hemorrhage (HP:0005261)3.87476015
20Double outlet right ventricle (HP:0001719)3.86886053
21Congenital malformation of the right heart (HP:0011723)3.86886053
22Abnormality of complement system (HP:0005339)3.80585395
23Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.79964606
24Epidermoid cyst (HP:0200040)3.76113930
25Abnormality of the intrinsic pathway (HP:0010989)3.71458842
26Hyperammonemia (HP:0001987)3.64666576
27Hyperglycemia (HP:0003074)3.64559169
28Hyperglycinemia (HP:0002154)3.56981981
29Retinal atrophy (HP:0001105)3.55316398
30Conjugated hyperbilirubinemia (HP:0002908)3.48021034
31Systemic lupus erythematosus (HP:0002725)3.45512035
32Abnormality of sulfur amino acid metabolism (HP:0004339)3.41652168
33Hypothermia (HP:0002045)3.39518365
34Late onset (HP:0003584)3.37263359
35Symptomatic seizures (HP:0011145)3.37061266
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.28064058
37Abnormality of methionine metabolism (HP:0010901)3.25859132
38Hyperglycinuria (HP:0003108)3.24425958
39Fat malabsorption (HP:0002630)3.22740015
40Vascular calcification (HP:0004934)3.16476236
41Abnormality of fatty-acid metabolism (HP:0004359)3.09826608
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.09588439
43Abnormality of glutamine family amino acid metabolism (HP:0010902)3.05124391
44Hyperbilirubinemia (HP:0002904)3.04441055
45Abnormality of glycine metabolism (HP:0010895)3.00926796
46Abnormality of serine family amino acid metabolism (HP:0010894)3.00926796
47Abnormality of endocrine pancreas physiology (HP:0012093)3.00728695
48Abnormality of the pancreatic islet cells (HP:0006476)3.00728695
49Pancreatic islet-cell hyperplasia (HP:0004510)2.96436911
50Glomerulonephritis (HP:0000099)2.95944596
51Large for gestational age (HP:0001520)2.92542240
52Hypercholesterolemia (HP:0003124)2.87683683
53Abnormality of the renal cortex (HP:0011035)2.81670033
54Enlarged penis (HP:0000040)2.80065552
55Medial flaring of the eyebrow (HP:0010747)2.76449914
56Cardiovascular calcification (HP:0011915)2.76383691
57Progressive macrocephaly (HP:0004481)2.73642737
58Skin nodule (HP:0200036)2.71249583
59Gout (HP:0001997)2.65506075
60Congenital sensorineural hearing impairment (HP:0008527)2.61616698
61Pancreatic fibrosis (HP:0100732)2.57673846
62Nephronophthisis (HP:0000090)2.57209416
63Renal cortical cysts (HP:0000803)2.56873308
64Delayed CNS myelination (HP:0002188)2.55479244
65Postural tremor (HP:0002174)2.54751192
66Irritability (HP:0000737)2.49814647
67Abnormality of pyrimidine metabolism (HP:0004353)2.49782641
68Mitral stenosis (HP:0001718)2.49373631
69Abnormal gallbladder morphology (HP:0012437)2.48425701
70Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46944740
71Abnormality of nucleobase metabolism (HP:0010932)2.46080288
72Progressive neurologic deterioration (HP:0002344)2.44376868
73Abnormality of purine metabolism (HP:0004352)2.44229111
74Pancreatic cysts (HP:0001737)2.43129805
75Abnormal albumin level (HP:0012116)2.42842495
76Hypoalbuminemia (HP:0003073)2.42842495
77Acute necrotizing encephalopathy (HP:0006965)2.42659320
78Tubular atrophy (HP:0000092)2.38977739
79Methylmalonic acidemia (HP:0002912)2.37637715
80Generalized aminoaciduria (HP:0002909)2.36741068
81Hepatocellular carcinoma (HP:0001402)2.35385730
82Metabolic acidosis (HP:0001942)2.34938948
83Attenuation of retinal blood vessels (HP:0007843)2.34274078
84Enlarged kidneys (HP:0000105)2.31801107
85Gaze-evoked nystagmus (HP:0000640)2.27124963
86Congenital stationary night blindness (HP:0007642)2.26114510
87Myocardial infarction (HP:0001658)2.23248248
88Sensorimotor neuropathy (HP:0007141)2.22270703
89Furrowed tongue (HP:0000221)2.21821855
90Tongue fasciculations (HP:0001308)2.20853415
91Dysostosis multiplex (HP:0000943)2.19194452
92Mitochondrial inheritance (HP:0001427)2.18274899
93Vacuolated lymphocytes (HP:0001922)2.16492736
943-Methylglutaconic aciduria (HP:0003535)2.15447204
95Conjunctival hamartoma (HP:0100780)2.14848819
96Amyloidosis (HP:0011034)2.14446430
97True hermaphroditism (HP:0010459)2.14402750
98Abnormality of the renal medulla (HP:0100957)2.14304688
99Abnormal rod and cone electroretinograms (HP:0008323)2.12704032
100Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11423088
101Dicarboxylic aciduria (HP:0003215)2.11423088
102Recurrent gram-negative bacterial infections (HP:0005420)2.10988968
103Abnormality of serum amino acid levels (HP:0003112)2.09165045
104Acute encephalopathy (HP:0006846)2.09007392
105Lethargy (HP:0001254)2.08403824
106Hematochezia (HP:0002573)2.08042324
107Aqueductal stenosis (HP:0002410)2.07870540
108Aplasia/Hypoplasia of the fovea (HP:0008060)2.07472701
109Hypoplasia of the fovea (HP:0007750)2.07472701
110Hypomagnesemia (HP:0002917)2.06973558
111Molar tooth sign on MRI (HP:0002419)2.06277089
112Abnormality of midbrain morphology (HP:0002418)2.06277089
113Cholelithiasis (HP:0001081)2.05591122
114Steatorrhea (HP:0002570)2.04589595
115Testicular neoplasm (HP:0010788)2.04235479
116Abnormal drinking behavior (HP:0030082)2.02795116
117Polydipsia (HP:0001959)2.02795116
118Increased CSF lactate (HP:0002490)2.02537811
119Hypochromic microcytic anemia (HP:0004840)2.02203930
120Spontaneous abortion (HP:0005268)2.01611523
121EEG with generalized epileptiform discharges (HP:0011198)2.00180095
122Bony spicule pigmentary retinopathy (HP:0007737)1.99905220
123Hepatic necrosis (HP:0002605)1.98364417
124Poor suck (HP:0002033)1.98333954
125Hyperthyroidism (HP:0000836)1.98062395
126Methylmalonic aciduria (HP:0012120)1.97658630
127Insulin-resistant diabetes mellitus (HP:0000831)1.95702072
128Brushfield spots (HP:0001088)1.94694153
129Muscular hypotonia of the trunk (HP:0008936)1.94120249
130Hypokinesia (HP:0002375)1.94101192
131Abnormality of abdominal situs (HP:0011620)1.94057951
132Abdominal situs inversus (HP:0003363)1.94057951
133Urinary glycosaminoglycan excretion (HP:0003541)1.93571856
134Mucopolysacchariduria (HP:0008155)1.93571856
135Urethral obstruction (HP:0000796)1.93275824
136Abnormality of the gallbladder (HP:0005264)1.92685376
137Epileptiform EEG discharges (HP:0011182)1.92297721
138Congenital primary aphakia (HP:0007707)1.91586363
139Neuroendocrine neoplasm (HP:0100634)1.89962039
140Renal Fanconi syndrome (HP:0001994)1.89433604
141Gait imbalance (HP:0002141)1.89315614
142Abnormal mitochondria in muscle tissue (HP:0008316)1.88676708
143Aplasia/hypoplasia of the uterus (HP:0008684)1.88232433
144Pancreatitis (HP:0001733)1.88163570
145Abnormal sex determination (HP:0012244)1.87682384
146Sex reversal (HP:0012245)1.87682384
147Anxiety (HP:0000739)1.87173957
148Lipid accumulation in hepatocytes (HP:0006561)1.86407162
149Progressive cerebellar ataxia (HP:0002073)1.86382342
150Proximal tubulopathy (HP:0000114)1.86179460
151Hypsarrhythmia (HP:0002521)1.85910585
152Insulin resistance (HP:0000855)1.85612500
153Abnormality of renal resorption (HP:0011038)1.85476660
154Acanthocytosis (HP:0001927)1.84916783
155Hamartoma of the eye (HP:0010568)1.84686682
156Pheochromocytoma (HP:0002666)1.84472600
157Gastrointestinal atresia (HP:0002589)1.84291341
158Agitation (HP:0000713)1.83904360
159Status epilepticus (HP:0002133)1.83903834
160Menorrhagia (HP:0000132)1.83742745
161Abnormality of calcium-phosphate metabolism (HP:0100530)1.79035785
162Esophageal varix (HP:0002040)1.78541317
163Nephritis (HP:0000123)1.78520644
164Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77927631
165Abnormality of polysaccharide metabolism (HP:0011012)1.77927631
166Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77927631
167Cerebral edema (HP:0002181)1.75736398
168Abnormality of urine glucose concentration (HP:0011016)1.75435584
169Glycosuria (HP:0003076)1.75435584
170Cholecystitis (HP:0001082)1.75339677
171Abnormal gallbladder physiology (HP:0012438)1.75339677
172Neonatal onset (HP:0003623)1.74129754
173Rickets (HP:0002748)1.72357729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.70404657
2WNK35.34211703
3PIK3CG4.65581117
4INSRR3.64704216
5MST43.39106798
6BCKDK3.28202824
7PHKG13.15438323
8PHKG23.15438323
9ERN12.98719284
10WNK42.94940528
11MAP4K22.92611327
12TAOK32.64521465
13SIK12.35776550
14FRK2.28055847
15MAP2K62.25017125
16FGFR42.19480321
17CASK2.04639759
18ADRBK22.00012032
19PTK61.96066419
20FGFR31.83793830
21MAP3K21.61478157
22TGFBR21.59004851
23MAP3K121.57060125
24TRPM71.49688185
25ACVR1B1.43765334
26STK31.43566766
27BMPR1B1.42142791
28PRKCE1.41437192
29NLK1.37711287
30STK241.33059388
31ERBB41.31259903
32STK38L1.30512858
33PRKD31.30291382
34UHMK11.28910530
35TRIB31.25771499
36MAP2K41.23884506
37CSNK1G11.17826619
38PNCK1.16675453
39FLT31.14326364
40DAPK21.10809577
41JAK21.10164949
42TNIK1.09729592
43PKN21.09269161
44TNK21.06888478
45RIPK11.05991720
46DYRK1B1.05763400
47PTK2B1.02287464
48STK391.02281460
49PLK21.01915296
50WNK11.00949856
51KSR20.99791097
52NEK90.99603397
53CAMK2D0.95751522
54MAPK110.91674016
55GRK70.91547503
56ERBB30.91058251
57CSNK1G30.90500166
58CSNK1G20.90106553
59MKNK20.88646520
60OXSR10.87966648
61PRKCI0.87461526
62CAMKK10.87337550
63PAK30.84527554
64MAP3K10.83207659
65CAMKK20.83103290
66JAK10.79728669
67CSK0.79679714
68HIPK20.79334973
69TYK20.78876531
70RET0.77688995
71IRAK30.75893725
72PINK10.75567422
73PRKAA20.72255642
74PTK20.71483789
75MST1R0.71451174
76EPHA30.69463129
77PRKCH0.68542668
78CAMK1D0.68422272
79TAOK10.67790653
80STK110.65559275
81PDPK10.64896817
82PRKAA10.63903226
83STK40.60213841
84GSK3A0.59913572
85NTRK10.59416406
86PRKCZ0.59380331
87YES10.59308470
88ZAK0.58922716
89SGK30.58524524
90PDK10.54464620
91PRKG10.53746580
92SGK20.53092023
93SGK2230.53046269
94SGK4940.53046269
95CSNK1A1L0.53002824
96CSF1R0.52411146
97LMTK20.52214142
98PRKACG0.51916554
99MAPK130.51001353
100MAP3K30.49439795
101EIF2AK30.48705085
102PRKCG0.48440631
103EPHB10.46547102
104MAP3K70.46468559
105AKT30.46035924
106MAP2K70.45063796
107CAMK2A0.43486991
108CAMK1G0.43223063
109ERBB20.43213285
110MAPK70.43090788
111CAMK40.41739520
112PRKACB0.41653497
113CSNK1D0.41543728
114ITK0.41147981
115TLK10.40780277
116IGF1R0.40264394
117MUSK0.40253406
118EIF2AK10.39866745
119NUAK10.38519898
120MAP3K90.37254507
121MAP2K20.36853203
122CAMK2G0.36757635
123ADRBK10.36722702
124FGFR20.36508552
125IRAK10.36484540
126MTOR0.35741540
127GRK10.35375366
128NTRK30.35086680
129STK380.34706471
130RPS6KB10.33445197
131MAP2K10.33358150
132LIMK10.32070809
133MAPKAPK30.31728937
134MYLK0.31607488
135TBK10.31012859
136BMPR20.30436056
137PRKCQ0.30118440
138CDC42BPA0.29685696
139MAPK40.29303756
140EPHA40.29283595
141AKT20.28696555
142MET0.28580650
143STK160.28169568
144PAK60.28076359
145MAP3K130.28053746
146FGFR10.27918273
147PRKCA0.27883952
148ROCK10.27273515
149CSNK1E0.26760432
150FER0.25961809
151CHUK0.25920997
152MAPK120.25520424
153RPS6KA30.24676112
154ABL20.24351116
155MAP3K40.23905800
156PDGFRA0.21880786
157PRKG20.21199392
158PRKD10.20661788
159PRKD20.20470108
160PRKACA0.20045591
161CSNK1A10.19572119
162SGK10.18649809

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.16728970
2Nitrogen metabolism_Homo sapiens_hsa009104.12323107
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.01701995
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.97260120
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.96574468
6Arginine biosynthesis_Homo sapiens_hsa002202.93730357
7Complement and coagulation cascades_Homo sapiens_hsa046102.67781617
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66766704
9Tryptophan metabolism_Homo sapiens_hsa003802.54702639
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.38306159
11Fatty acid degradation_Homo sapiens_hsa000712.36607052
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32438276
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31183918
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19274651
15Oxidative phosphorylation_Homo sapiens_hsa001902.13593750
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12853380
17Butanoate metabolism_Homo sapiens_hsa006502.12024996
18Peroxisome_Homo sapiens_hsa041461.94038367
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.87153859
20Collecting duct acid secretion_Homo sapiens_hsa049661.79175715
21Propanoate metabolism_Homo sapiens_hsa006401.78005093
22Fatty acid metabolism_Homo sapiens_hsa012121.77661964
23Staphylococcus aureus infection_Homo sapiens_hsa051501.74761977
24PPAR signaling pathway_Homo sapiens_hsa033201.72188768
25Bile secretion_Homo sapiens_hsa049761.70599813
26Histidine metabolism_Homo sapiens_hsa003401.69321916
27Chemical carcinogenesis_Homo sapiens_hsa052041.64011521
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.61123554
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58619068
30Sulfur metabolism_Homo sapiens_hsa009201.58519526
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56720888
32Retinol metabolism_Homo sapiens_hsa008301.54297887
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.51666577
34ABC transporters_Homo sapiens_hsa020101.50961244
35Starch and sucrose metabolism_Homo sapiens_hsa005001.47364878
36Selenocompound metabolism_Homo sapiens_hsa004501.46674503
37beta-Alanine metabolism_Homo sapiens_hsa004101.45555454
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43276235
39Caffeine metabolism_Homo sapiens_hsa002321.38766924
40Phenylalanine metabolism_Homo sapiens_hsa003601.36141608
41Phototransduction_Homo sapiens_hsa047441.35871257
42Tyrosine metabolism_Homo sapiens_hsa003501.31562359
43Sphingolipid metabolism_Homo sapiens_hsa006001.30711836
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29968392
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.28528003
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27215680
47Folate biosynthesis_Homo sapiens_hsa007901.25790598
48Fat digestion and absorption_Homo sapiens_hsa049751.24052846
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.22137539
50Fatty acid elongation_Homo sapiens_hsa000621.22065077
51Parkinsons disease_Homo sapiens_hsa050121.15785253
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12056565
53Pyruvate metabolism_Homo sapiens_hsa006201.07791696
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.03291539
55Mineral absorption_Homo sapiens_hsa049781.01560099
56Alzheimers disease_Homo sapiens_hsa050100.99151461
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.94835827
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94576511
59Synaptic vesicle cycle_Homo sapiens_hsa047210.93770568
60Prion diseases_Homo sapiens_hsa050200.93647915
61Renin secretion_Homo sapiens_hsa049240.93000774
62Circadian entrainment_Homo sapiens_hsa047130.87733423
63Carbon metabolism_Homo sapiens_hsa012000.84786552
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.83272749
65Vitamin digestion and absorption_Homo sapiens_hsa049770.83029682
66Biosynthesis of amino acids_Homo sapiens_hsa012300.82317613
67Serotonergic synapse_Homo sapiens_hsa047260.82172653
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81835308
69Vibrio cholerae infection_Homo sapiens_hsa051100.80757078
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79031345
71Arginine and proline metabolism_Homo sapiens_hsa003300.77889093
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76741913
73Steroid biosynthesis_Homo sapiens_hsa001000.76334298
74Lysine degradation_Homo sapiens_hsa003100.76064440
75Cardiac muscle contraction_Homo sapiens_hsa042600.75762923
76Amphetamine addiction_Homo sapiens_hsa050310.74842542
77Arachidonic acid metabolism_Homo sapiens_hsa005900.74618348
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73146563
79Dopaminergic synapse_Homo sapiens_hsa047280.72863208
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69474176
81Insulin secretion_Homo sapiens_hsa049110.67467040
82Glutamatergic synapse_Homo sapiens_hsa047240.66504343
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63591901
84Huntingtons disease_Homo sapiens_hsa050160.63075073
85Pancreatic secretion_Homo sapiens_hsa049720.60051746
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58434397
87Glycerolipid metabolism_Homo sapiens_hsa005610.53907401
88Salivary secretion_Homo sapiens_hsa049700.53300330
89Glucagon signaling pathway_Homo sapiens_hsa049220.51958726
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51825695
91Long-term depression_Homo sapiens_hsa047300.50865127
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50471145
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49897572
94Dorso-ventral axis formation_Homo sapiens_hsa043200.46128176
95Sulfur relay system_Homo sapiens_hsa041220.45686337
96Protein export_Homo sapiens_hsa030600.43933900
97Ovarian steroidogenesis_Homo sapiens_hsa049130.43730258
98Morphine addiction_Homo sapiens_hsa050320.43012235
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42392006
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41092585
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.40683098
102Metabolic pathways_Homo sapiens_hsa011000.39963235
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.39867890
104Lysosome_Homo sapiens_hsa041420.39343701
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38218732
106Vitamin B6 metabolism_Homo sapiens_hsa007500.38039224
107Glutathione metabolism_Homo sapiens_hsa004800.37358470
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36987681
109Nicotine addiction_Homo sapiens_hsa050330.35915944
110Insulin resistance_Homo sapiens_hsa049310.34424998
111Other glycan degradation_Homo sapiens_hsa005110.34273983
112Type II diabetes mellitus_Homo sapiens_hsa049300.32173901
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.31629550
114Linoleic acid metabolism_Homo sapiens_hsa005910.30681598
115Regulation of autophagy_Homo sapiens_hsa041400.28526911
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28109282
117Pentose phosphate pathway_Homo sapiens_hsa000300.26295263
118Galactose metabolism_Homo sapiens_hsa000520.23932182
119Fatty acid biosynthesis_Homo sapiens_hsa000610.22371411
120Thyroid hormone synthesis_Homo sapiens_hsa049180.22100197
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.21226546
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.20503667
123Adipocytokine signaling pathway_Homo sapiens_hsa049200.20096202
124Fructose and mannose metabolism_Homo sapiens_hsa000510.19862581
125Circadian rhythm_Homo sapiens_hsa047100.14548065
126GABAergic synapse_Homo sapiens_hsa047270.13387225
127One carbon pool by folate_Homo sapiens_hsa006700.13254547
128Type I diabetes mellitus_Homo sapiens_hsa049400.13229383
129Cocaine addiction_Homo sapiens_hsa050300.10941139
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08878487
131Ether lipid metabolism_Homo sapiens_hsa005650.07612699
132AMPK signaling pathway_Homo sapiens_hsa041520.07433166
133Insulin signaling pathway_Homo sapiens_hsa049100.04351006
134N-Glycan biosynthesis_Homo sapiens_hsa005100.01084291
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01069910

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