TTYH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-independent, volume-sensitive large conductance chloride(-) channel. Three transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.81279297
2central nervous system myelination (GO:0022010)5.81279297
3L-amino acid import (GO:0043092)5.17715497
4locomotory exploration behavior (GO:0035641)4.80773820
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.71315407
6cellular potassium ion homeostasis (GO:0030007)4.51283604
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45775530
8neuron cell-cell adhesion (GO:0007158)4.39046261
9gamma-aminobutyric acid transport (GO:0015812)4.35415562
10synaptic vesicle maturation (GO:0016188)4.33034520
11amino acid import (GO:0043090)4.25590683
12pyrimidine nucleobase catabolic process (GO:0006208)4.23090200
13neuronal stem cell maintenance (GO:0097150)4.20821613
14neuronal action potential propagation (GO:0019227)4.14821428
15synaptic vesicle exocytosis (GO:0016079)4.11549613
16astrocyte differentiation (GO:0048708)4.08326593
17transmission of nerve impulse (GO:0019226)4.06789367
18sodium ion export (GO:0071436)4.03484499
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.01489816
20vocalization behavior (GO:0071625)4.00330981
21negative regulation of oligodendrocyte differentiation (GO:0048715)3.98369377
22presynaptic membrane assembly (GO:0097105)3.94654481
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.93296619
24glutamate secretion (GO:0014047)3.88552682
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.86459635
26cerebellar granule cell differentiation (GO:0021707)3.82444511
27myelination (GO:0042552)3.82370623
28negative regulation of astrocyte differentiation (GO:0048712)3.80836052
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79260477
30axon ensheathment (GO:0008366)3.75668971
31ensheathment of neurons (GO:0007272)3.75668971
32regulation of synaptic vesicle exocytosis (GO:2000300)3.71238976
33glutamate receptor signaling pathway (GO:0007215)3.64351341
34protein localization to synapse (GO:0035418)3.64081231
35presynaptic membrane organization (GO:0097090)3.63772464
36synaptic transmission, glutamatergic (GO:0035249)3.60698755
37neurotransmitter-gated ion channel clustering (GO:0072578)3.59943154
38dendritic spine morphogenesis (GO:0060997)3.55240813
39layer formation in cerebral cortex (GO:0021819)3.55092805
40establishment of mitochondrion localization (GO:0051654)3.53777036
41mechanosensory behavior (GO:0007638)3.50370792
42response to auditory stimulus (GO:0010996)3.47952056
43regulation of glutamate receptor signaling pathway (GO:1900449)3.47752393
44potassium ion import (GO:0010107)3.47610344
45positive regulation of synapse assembly (GO:0051965)3.46982771
46regulation of neuronal synaptic plasticity (GO:0048168)3.46764761
47regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46161054
48neuronal ion channel clustering (GO:0045161)3.44556887
49potassium ion homeostasis (GO:0055075)3.42299202
50regulation of neurotransmitter uptake (GO:0051580)3.41421232
51nucleobase catabolic process (GO:0046113)3.40338094
52cellular response to cholesterol (GO:0071397)3.39633562
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39520837
54exploration behavior (GO:0035640)3.39272185
55auditory behavior (GO:0031223)3.39245781
56nonmotile primary cilium assembly (GO:0035058)3.39061532
57neurotransmitter secretion (GO:0007269)3.37681272
58neuron-neuron synaptic transmission (GO:0007270)3.35412688
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35128618
60G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.35029274
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34736033
62negative regulation of glial cell differentiation (GO:0045686)3.32575816
63synaptic vesicle endocytosis (GO:0048488)3.32246832
64neurotransmitter uptake (GO:0001504)3.29619602
65C4-dicarboxylate transport (GO:0015740)3.29330027
66regulation of synapse structural plasticity (GO:0051823)3.27941989
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.26369746
68positive regulation of membrane potential (GO:0045838)3.22393587
69long-term memory (GO:0007616)3.20345868
70positive regulation of vascular permeability (GO:0043117)3.19658653
71adult walking behavior (GO:0007628)3.19222125
72retinal rod cell development (GO:0046548)3.18364581
73dendrite morphogenesis (GO:0048813)3.15744063
74central nervous system projection neuron axonogenesis (GO:0021952)3.15427579
75regulation of synaptic vesicle transport (GO:1902803)3.15208436
76negative regulation of neurotransmitter transport (GO:0051589)3.12920271
77negative regulation of cytosolic calcium ion concentration (GO:0051481)3.12167909
78oligodendrocyte differentiation (GO:0048709)3.10844328
79regulation of synaptic transmission, glutamatergic (GO:0051966)3.10107876
80negative regulation of neurotransmitter secretion (GO:0046929)3.09623469
81negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07241958
82regulation of dendritic spine morphogenesis (GO:0061001)3.06968021
83long-term synaptic potentiation (GO:0060291)3.06845492
84cellular sodium ion homeostasis (GO:0006883)3.06613050
85neurotransmitter transport (GO:0006836)3.06238418
86prepulse inhibition (GO:0060134)3.05729721
87calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.05728216
88dendritic spine organization (GO:0097061)3.05257420
89regulation of Rac GTPase activity (GO:0032314)3.03270593
90membrane hyperpolarization (GO:0060081)3.03173413
91postsynaptic membrane organization (GO:0001941)3.01051653
92synaptic vesicle docking involved in exocytosis (GO:0016081)2.99394208
93regulation of neurotransmitter transport (GO:0051588)2.99336765
94epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98291104
95cell communication by electrical coupling (GO:0010644)2.98240026
96neuron recognition (GO:0008038)2.96777129
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96394430
98retinal ganglion cell axon guidance (GO:0031290)2.94714103
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.94339750
100regulation of voltage-gated calcium channel activity (GO:1901385)2.89872155
101tongue development (GO:0043586)2.89755155
102cerebral cortex radially oriented cell migration (GO:0021799)2.89016309
103neuron fate determination (GO:0048664)2.88902440
104regulation of synaptic plasticity (GO:0048167)2.88864302
105appendage development (GO:0048736)2.87658786
106limb development (GO:0060173)2.87658786
107positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86245340
108acidic amino acid transport (GO:0015800)2.85365322
109glial cell differentiation (GO:0010001)2.84672516
110regulation of postsynaptic membrane potential (GO:0060078)2.84050411
111neuromuscular process controlling balance (GO:0050885)2.83688108
112regulation of neurotransmitter levels (GO:0001505)2.83452015
113glycine transport (GO:0015816)2.82542216
114dermatan sulfate biosynthetic process (GO:0030208)2.82439160
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.82018708
116astrocyte development (GO:0014002)2.81444788
117regulation of respiratory system process (GO:0044065)2.80746076
118positive regulation of dendritic spine development (GO:0060999)2.80009964
119peripheral nervous system axon ensheathment (GO:0032292)2.78193317
120myelination in peripheral nervous system (GO:0022011)2.78193317
121L-glutamate transport (GO:0015813)2.78118673
122radial glial cell differentiation (GO:0060019)2.77600672
123forebrain neuron differentiation (GO:0021879)2.77399968
124fatty acid elongation (GO:0030497)2.76242857
125synapse assembly (GO:0007416)2.75622604
126negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.75276535
127regulation of vesicle fusion (GO:0031338)2.75165353
128neurotransmitter catabolic process (GO:0042135)2.73132467
129regulation of dendritic spine development (GO:0060998)2.72777778
130regulation of neurotransmitter secretion (GO:0046928)2.72511036
131axonal fasciculation (GO:0007413)2.71854004
132synapse organization (GO:0050808)2.71577151
133photoreceptor cell differentiation (GO:0046530)2.71449517
134eye photoreceptor cell differentiation (GO:0001754)2.71449517
135mechanoreceptor differentiation (GO:0042490)2.69645179
136regulation of respiratory gaseous exchange (GO:0043576)2.69177364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.46902491
2GBX2_23144817_ChIP-Seq_PC3_Human3.42877970
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06318425
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99722610
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98410686
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67290235
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67290235
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.57202779
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.55023841
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51483581
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51212829
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48173007
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46164961
14DROSHA_22980978_ChIP-Seq_HELA_Human2.45517952
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.42935108
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41194351
17REST_21632747_ChIP-Seq_MESCs_Mouse2.30200935
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.28228757
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25926565
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.23735479
21AR_21572438_ChIP-Seq_LNCaP_Human2.19274959
22* RARB_27405468_Chip-Seq_BRAIN_Mouse2.14359676
23IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83296161
24RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.83273156
25REST_18959480_ChIP-ChIP_MESCs_Mouse1.80691426
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68615318
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67181015
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65127187
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65000485
30IGF1R_20145208_ChIP-Seq_DFB_Human1.60522156
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60026435
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59815910
33RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59581505
34TAF15_26573619_Chip-Seq_HEK293_Human1.56150418
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.54896780
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54835764
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47952829
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46402909
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46075082
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43390894
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43264909
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41142797
43SMAD4_21799915_ChIP-Seq_A2780_Human1.40603188
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40293100
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39158756
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38735769
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.38368831
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.38143617
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.36880201
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.36445474
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33377260
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33296570
53P300_19829295_ChIP-Seq_ESCs_Human1.31858864
54* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26527006
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.25561794
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23843444
57STAT3_23295773_ChIP-Seq_U87_Human1.22306173
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20605463
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19639579
60RING1B_27294783_Chip-Seq_NPCs_Mouse1.17856143
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16945097
62P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16661395
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16135516
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16102030
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.15941889
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13003742
67AR_19668381_ChIP-Seq_PC3_Human1.12562111
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09744879
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08888321
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08824991
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.07888075
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07696016
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07629126
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07596032
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06522295
76AR_25329375_ChIP-Seq_VCAP_Human1.06401754
77E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06121483
78TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05802201
79TCF4_23295773_ChIP-Seq_U87_Human1.04493040
80ER_23166858_ChIP-Seq_MCF-7_Human1.03629909
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02894607
82RNF2_27304074_Chip-Seq_NSC_Mouse1.02814826
83SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02601818
84SOX9_26525672_Chip-Seq_HEART_Mouse1.01983694
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00939251
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00244213
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99698680
88ZNF274_21170338_ChIP-Seq_K562_Hela0.99085962
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98711513
90FUS_26573619_Chip-Seq_HEK293_Human0.98398022
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.98001006
92SMAD_19615063_ChIP-ChIP_OVARY_Human0.96715322
93YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96059099
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95810246
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.95209755
96SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94551659
97POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94313727
98RUNX2_22187159_ChIP-Seq_PCA_Human0.94250969
99VDR_22108803_ChIP-Seq_LS180_Human0.93780299
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.93567794
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93493600
102FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93459269
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93009331
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93006823
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92022294
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92022294
107CTCF_27219007_Chip-Seq_Bcells_Human0.91573537
108AHR_22903824_ChIP-Seq_MCF-7_Human0.90828341
109POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90758487
110SMAD4_21741376_ChIP-Seq_HESCs_Human0.90738221
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89838466
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.89624005
113ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89554682
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89399737
115* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.88991650
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88727631
117MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88582106
118TP53_16413492_ChIP-PET_HCT116_Human0.88370572
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87515919
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.86935943
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.86536883
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86180894
123CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86148180
124RXR_22108803_ChIP-Seq_LS180_Human0.86112763
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.85723199
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85591939
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84711277
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84194445
129RUNX1_26923725_Chip-Seq_HPCs_Mouse0.83896787
130NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82859710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.09215654
2MP0003880_abnormal_central_pattern4.30883179
3MP0004270_analgesia3.79287046
4MP0003635_abnormal_synaptic_transmissio3.46519864
5MP0005423_abnormal_somatic_nervous3.33361048
6MP0002064_seizures3.00690669
7MP0009745_abnormal_behavioral_response2.98886324
8MP0001486_abnormal_startle_reflex2.98245478
9MP0009046_muscle_twitch2.95322059
10MP0004885_abnormal_endolymph2.80959402
11MP0002272_abnormal_nervous_system2.69118188
12MP0002063_abnormal_learning/memory/cond2.67375679
13MP0003690_abnormal_glial_cell2.52716698
14MP0000920_abnormal_myelination2.47341027
15MP0002572_abnormal_emotion/affect_behav2.42034148
16MP0002734_abnormal_mechanical_nocicepti2.36380905
17MP0003329_amyloid_beta_deposits2.22377053
18MP0001968_abnormal_touch/_nociception2.18464527
19MP0000778_abnormal_nervous_system2.14880614
20MP0003122_maternal_imprinting2.02185448
21MP0004858_abnormal_nervous_system1.99563565
22MP0001440_abnormal_grooming_behavior1.97549435
23MP0006292_abnormal_olfactory_placode1.97519133
24MP0002822_catalepsy1.93851536
25MP0008569_lethality_at_weaning1.92082865
26MP0002067_abnormal_sensory_capabilities1.90598341
27MP0001485_abnormal_pinna_reflex1.89350909
28MP0005551_abnormal_eye_electrophysiolog1.87907882
29MP0003634_abnormal_glial_cell1.81902754
30MP0009780_abnormal_chondrocyte_physiolo1.78950912
31MP0004742_abnormal_vestibular_system1.73390166
32MP0005646_abnormal_pituitary_gland1.71289172
33MP0001501_abnormal_sleep_pattern1.70386738
34MP0002736_abnormal_nociception_after1.70095176
35MP0003136_yellow_coat_color1.69672904
36MP0001984_abnormal_olfaction1.66569604
37MP0002733_abnormal_thermal_nociception1.63745107
38MP0004142_abnormal_muscle_tone1.61729951
39MP0001529_abnormal_vocalization1.61547298
40MP0000955_abnormal_spinal_cord1.61337572
41MP0001905_abnormal_dopamine_level1.60936380
42MP0002882_abnormal_neuron_morphology1.59386395
43MP0001970_abnormal_pain_threshold1.57468189
44MP0002557_abnormal_social/conspecific_i1.55862742
45MP0004924_abnormal_behavior1.54502154
46MP0005386_behavior/neurological_phenoty1.54502154
47MP0001502_abnormal_circadian_rhythm1.52945268
48MP0002229_neurodegeneration1.46314233
49MP0005248_abnormal_Harderian_gland1.43269946
50MP0002066_abnormal_motor_capabilities/c1.40877063
51MP0003632_abnormal_nervous_system1.39059121
52MP0003633_abnormal_nervous_system1.38154619
53MP0004133_heterotaxia1.35594830
54MP0005171_absent_coat_pigmentation1.32450313
55MP0003631_nervous_system_phenotype1.31642737
56MP0002184_abnormal_innervation1.30521612
57MP0006072_abnormal_retinal_apoptosis1.25574196
58MP0002090_abnormal_vision1.25189472
59MP0004811_abnormal_neuron_physiology1.23053792
60MP0008789_abnormal_olfactory_epithelium1.21387240
61MP0001293_anophthalmia1.21354358
62MP0002152_abnormal_brain_morphology1.20023700
63MP0001963_abnormal_hearing_physiology1.19875820
64MP0002735_abnormal_chemical_nociception1.18812916
65MP0002249_abnormal_larynx_morphology1.15318105
66MP0005253_abnormal_eye_physiology1.15214279
67MP0005409_darkened_coat_color1.13400573
68MP0005645_abnormal_hypothalamus_physiol1.12033254
69MP0002752_abnormal_somatic_nervous1.10894752
70MP0001346_abnormal_lacrimal_gland1.06029544
71MP0001299_abnormal_eye_distance/1.03490686
72MP0000049_abnormal_middle_ear1.02081678
73MP0004043_abnormal_pH_regulation1.01709224
74MP0000604_amyloidosis0.99454469
75MP0002938_white_spotting0.98753180
76MP0003011_delayed_dark_adaptation0.97558032
77MP0002909_abnormal_adrenal_gland0.96157484
78MP0005623_abnormal_meninges_morphology0.94452328
79MP0001177_atelectasis0.94104237
80MP0000026_abnormal_inner_ear0.93408042
81MP0000631_abnormal_neuroendocrine_gland0.92405127
82MP0003075_altered_response_to0.92248752
83MP0003879_abnormal_hair_cell0.91957218
84MP0003121_genomic_imprinting0.91600530
85MP0010030_abnormal_orbit_morphology0.90115314
86MP0002638_abnormal_pupillary_reflex0.88216894
87MP0005391_vision/eye_phenotype0.87891858
88MP0006276_abnormal_autonomic_nervous0.84212646
89MP0005195_abnormal_posterior_eye0.82754455
90MP0000579_abnormal_nail_morphology0.82627394
91MP0003137_abnormal_impulse_conducting0.81992498
92MP0004145_abnormal_muscle_electrophysio0.80545573
93MP0009379_abnormal_foot_pigmentation0.80244708
94MP0005167_abnormal_blood-brain_barrier0.77492527
95MP0005410_abnormal_fertilization0.76677099
96MP0000566_synostosis0.76013308
97MP0005174_abnormal_tail_pigmentation0.75398458
98MP0002069_abnormal_eating/drinking_beha0.75149485
99MP0002653_abnormal_ependyma_morphology0.73898017
100MP0003787_abnormal_imprinting0.73585002
101MP0001188_hyperpigmentation0.71086912
102MP0000647_abnormal_sebaceous_gland0.70986087
103MP0003283_abnormal_digestive_organ0.70413598
104MP0002092_abnormal_eye_morphology0.69945286
105MP0002233_abnormal_nose_morphology0.69335207
106MP0003950_abnormal_plasma_membrane0.68988269
107MP0003938_abnormal_ear_development0.67822418
108MP0003878_abnormal_ear_physiology0.67462351
109MP0005377_hearing/vestibular/ear_phenot0.67462351
110MP0000462_abnormal_digestive_system0.66791834
111MP0003861_abnormal_nervous_system0.65777159
112MP0008874_decreased_physiological_sensi0.65273218
113MP0004085_abnormal_heartbeat0.61819434
114MP0005499_abnormal_olfactory_system0.59843032
115MP0005394_taste/olfaction_phenotype0.59843032
116MP0001943_abnormal_respiration0.59710233
117MP0000751_myopathy0.59106945
118MP0008872_abnormal_physiological_respon0.58662768
119MP0001664_abnormal_digestion0.57664534
120MP0002089_abnormal_postnatal_growth/wei0.52094066
121MP0010769_abnormal_survival0.50349117

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.40350271
2Myokymia (HP:0002411)5.32905344
3Neurofibrillary tangles (HP:0002185)4.71879507
4Megalencephaly (HP:0001355)4.15960921
5Epileptic encephalopathy (HP:0200134)4.06569808
6Focal seizures (HP:0007359)4.03043998
7Supranuclear gaze palsy (HP:0000605)3.96918018
8Action tremor (HP:0002345)3.76003450
9Atonic seizures (HP:0010819)3.66896091
10Aplasia involving bones of the upper limbs (HP:0009823)3.65961180
11Aplasia of the phalanges of the hand (HP:0009802)3.65961180
12Aplasia involving bones of the extremities (HP:0009825)3.65961180
13Progressive cerebellar ataxia (HP:0002073)3.62830093
14Cerebral inclusion bodies (HP:0100314)3.54825886
15Hemiparesis (HP:0001269)3.54595059
16Dysmetria (HP:0001310)3.44373988
17Dysdiadochokinesis (HP:0002075)3.37306373
18Intention tremor (HP:0002080)3.37017339
19Degeneration of the lateral corticospinal tracts (HP:0002314)3.31062799
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.31062799
21Ankle clonus (HP:0011448)3.17389164
22Diplopia (HP:0000651)3.16737263
23Abnormality of binocular vision (HP:0011514)3.16737263
24Generalized tonic-clonic seizures (HP:0002069)3.16145534
25Spastic gait (HP:0002064)3.15696713
26Peripheral hypomyelination (HP:0007182)3.12568801
27Visual hallucinations (HP:0002367)3.09802144
28Absence seizures (HP:0002121)3.04430938
29Abnormality of the diencephalon (HP:0010662)3.02646799
30True hermaphroditism (HP:0010459)3.01677612
31Abnormality of the corticospinal tract (HP:0002492)3.01204000
32Gait imbalance (HP:0002141)2.97862849
33Hemiplegia (HP:0002301)2.96492195
34Dialeptic seizures (HP:0011146)2.94170571
35Gaze-evoked nystagmus (HP:0000640)2.83124332
36Febrile seizures (HP:0002373)2.75368467
37Split foot (HP:0001839)2.74710912
38Broad-based gait (HP:0002136)2.71748172
39Scanning speech (HP:0002168)2.68225152
40Clumsiness (HP:0002312)2.67729729
41Humeroradial synostosis (HP:0003041)2.65976407
42Synostosis involving the elbow (HP:0003938)2.65976407
43Abnormal eating behavior (HP:0100738)2.64027377
44Postural instability (HP:0002172)2.61317364
45Rib fusion (HP:0000902)2.58994519
46Congenital primary aphakia (HP:0007707)2.54901599
47Medial flaring of the eyebrow (HP:0010747)2.53434179
48Sensory axonal neuropathy (HP:0003390)2.52585373
49Pancreatic fibrosis (HP:0100732)2.51147869
50Oligodactyly (HP:0012165)2.48859884
51Optic nerve hypoplasia (HP:0000609)2.47554956
52Urinary bladder sphincter dysfunction (HP:0002839)2.47495548
53Truncal ataxia (HP:0002078)2.45830049
54Abnormality of the 4th metacarpal (HP:0010012)2.44943055
55Thickened helices (HP:0000391)2.44840084
56Depression (HP:0000716)2.43029836
57Hyperventilation (HP:0002883)2.42794052
58Increased circulating renin level (HP:0000848)2.39397136
59Alacrima (HP:0000522)2.38283201
60Anxiety (HP:0000739)2.37547008
61Akinesia (HP:0002304)2.37146050
62Lower limb muscle weakness (HP:0007340)2.36500530
63Nephrogenic diabetes insipidus (HP:0009806)2.28162827
64Specific learning disability (HP:0001328)2.26971888
65Anophthalmia (HP:0000528)2.25890120
66Impaired vibration sensation in the lower limbs (HP:0002166)2.25519421
67Retinal dysplasia (HP:0007973)2.23200029
68Termporal pattern (HP:0011008)2.22241896
69Insidious onset (HP:0003587)2.22241896
70Trigonocephaly (HP:0000243)2.18905581
71Hyperglycinemia (HP:0002154)2.17496767
72Postaxial foot polydactyly (HP:0001830)2.16404779
73Abnormality of midbrain morphology (HP:0002418)2.16131993
74Molar tooth sign on MRI (HP:0002419)2.16131993
75Partial duplication of thumb phalanx (HP:0009944)2.14047806
76Broad foot (HP:0001769)2.13455876
77Postaxial hand polydactyly (HP:0001162)2.13445778
78Generalized myoclonic seizures (HP:0002123)2.12272218
79Turricephaly (HP:0000262)2.10280803
80Pancreatic cysts (HP:0001737)2.08856980
81Annular pancreas (HP:0001734)2.04726666
82Slow saccadic eye movements (HP:0000514)2.04657886
83Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03840075
84Clonus (HP:0002169)2.03662822
85Genital tract atresia (HP:0001827)2.03365817
86Onion bulb formation (HP:0003383)2.01127957
87Nephronophthisis (HP:0000090)2.00947909
88Pheochromocytoma (HP:0002666)2.00820055
89Vaginal atresia (HP:0000148)2.00643428
90Drooling (HP:0002307)2.00635479
91Excessive salivation (HP:0003781)2.00635479
92Abnormality of the labia minora (HP:0012880)2.00162457
93Fibular hypoplasia (HP:0003038)2.00004068
94Heterochromia iridis (HP:0001100)1.96678255
95Urinary urgency (HP:0000012)1.96431658
96Sclerocornea (HP:0000647)1.96425850
97Absent septum pellucidum (HP:0001331)1.96369136
98Esophageal atresia (HP:0002032)1.95288313
99Progressive inability to walk (HP:0002505)1.94832595
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.94500446
101Absent/shortened dynein arms (HP:0200106)1.94500446
102Genetic anticipation (HP:0003743)1.94220211
103Morphological abnormality of the inner ear (HP:0011390)1.93906998
104Mutism (HP:0002300)1.91138250
105Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91057569
106Short 4th metacarpal (HP:0010044)1.91057569
107Decreased lacrimation (HP:0000633)1.90758894
108Coronal craniosynostosis (HP:0004440)1.90549294
109Polyphagia (HP:0002591)1.89205706
110Cutaneous finger syndactyly (HP:0010554)1.88870533
111Abnormal auditory evoked potentials (HP:0006958)1.88101872
112Mixed hearing impairment (HP:0000410)1.87906535
113Poor eye contact (HP:0000817)1.87271631
114Hemivertebrae (HP:0002937)1.85319445
115Anteriorly placed anus (HP:0001545)1.85233300
116Gastrointestinal atresia (HP:0002589)1.85015565
117Type II lissencephaly (HP:0007260)1.84604362
118Stereotypic behavior (HP:0000733)1.84084902
119Status epilepticus (HP:0002133)1.83245065
120Abnormality of saccadic eye movements (HP:0000570)1.82722722
121Morphological abnormality of the pyramidal tract (HP:0002062)1.80388597
122Hypoplastic pelvis (HP:0008839)1.78868770
123Aplasia/Hypoplasia of the fibula (HP:0006492)1.78591513
124Hypoplasia of the corpus callosum (HP:0002079)1.78462690
125Abnormality of the middle phalanges of the toes (HP:0010183)1.78416983
126Metabolic alkalosis (HP:0200114)1.78329186
127Cystic liver disease (HP:0006706)1.78304372
128Poor coordination (HP:0002370)1.77900947
129Oligodactyly (hands) (HP:0001180)1.77319499
130Maternal diabetes (HP:0009800)1.77311906
131Torticollis (HP:0000473)1.77253419
132EEG with generalized epileptiform discharges (HP:0011198)1.76315119
133Epileptiform EEG discharges (HP:0011182)1.76194819
134Abnormal social behavior (HP:0012433)1.75763057
135Impaired social interactions (HP:0000735)1.75763057
136Cortical dysplasia (HP:0002539)1.75562245
137Neuroendocrine neoplasm (HP:0100634)1.74484221
138Bronchomalacia (HP:0002780)1.74018275
139Vitreoretinal degeneration (HP:0000655)1.73972666
140Fetal akinesia sequence (HP:0001989)1.73843044
141Absent speech (HP:0001344)1.73573017
142Hyperglycinuria (HP:0003108)1.72914029
143Bowel incontinence (HP:0002607)1.72398752
144Neuronal loss in central nervous system (HP:0002529)1.72336321
145Renal dysplasia (HP:0000110)1.71425237
146Sleep apnea (HP:0010535)1.71373995
147Bradykinesia (HP:0002067)1.71107533
148Cutaneous syndactyly (HP:0012725)1.70816831
149Abnormality of glycine metabolism (HP:0010895)1.70144970
150Abnormality of serine family amino acid metabolism (HP:0010894)1.70144970
151Limb dystonia (HP:0002451)1.69935206
152Hypoplastic nipples (HP:0002557)1.69826283
153Partial duplication of the phalanx of hand (HP:0009999)1.69329583
154Confusion (HP:0001289)1.69005322
155Abnormality of macular pigmentation (HP:0008002)1.68879497
156Septo-optic dysplasia (HP:0100842)1.68729877
157Abnormal ciliary motility (HP:0012262)1.68568913
158Supernumerary spleens (HP:0009799)1.67718064
159Hepatoblastoma (HP:0002884)1.67312508
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66506698
161Occipital encephalocele (HP:0002085)1.65409919

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.39154355
2TNIK3.85041251
3STK393.01185266
4NTRK32.83249452
5OXSR12.60917816
6NTRK22.43194192
7PAK62.38633892
8MARK12.31528608
9MAP3K92.31390302
10MAPK152.27240424
11EPHA32.17241934
12PRPF4B2.06500279
13PRKD32.05569786
14CASK1.96876516
15CDK191.95841898
16NTRK11.86777361
17MINK11.84654529
18EPHB21.83461712
19MAP3K41.79532127
20DYRK21.72276431
21TYRO31.67794025
22PHKG21.60465587
23PHKG11.60465587
24NEK61.60012935
25PNCK1.54994738
26UHMK11.50817993
27CDK51.49577663
28BCKDK1.46687871
29MAPK131.43520099
30MAP2K71.41254949
31DAPK21.41086035
32ICK1.37674557
33WNK11.36572596
34KSR21.35366382
35SGK4941.34305802
36SGK2231.34305802
37LMTK21.29326307
38BCR1.25142079
39FES1.23908136
40PKN11.20968307
41WNK41.19249546
42FGFR21.18565692
43WNK31.15191249
44PAK31.09972001
45EPHB11.09566548
46CAMKK11.08569434
47KSR11.07723742
48FGR1.03422370
49ROCK21.03346074
50MAP3K131.02568366
51CAMK2B1.02024709
52CDK141.01914159
53CSNK1G21.01210265
54CDK151.00839315
55CAMK2A0.99600782
56PRKCG0.97699929
57ARAF0.97693008
58CDK180.97611086
59MAP4K20.94051311
60PRKCH0.92544481
61CDK11A0.88750161
62ERBB20.88142675
63CAMK2D0.87206258
64IRAK20.85317512
65STK110.84842095
66CAMK1G0.83745690
67PINK10.83477067
68PLK20.82497848
69MOS0.81805971
70CSNK1A1L0.80845787
71CSNK1G30.79410258
72MAP2K40.77407281
73STK380.76161492
74MARK20.74835454
75DYRK1A0.73357430
76CAMK2G0.72763308
77SGK20.72676143
78GRK50.72127183
79MUSK0.71237401
80RIPK40.69766063
81PDPK10.66758850
82PRKCE0.65110555
83FYN0.64631638
84MAP3K20.64061465
85DYRK1B0.63878652
86BMPR1B0.63604803
87CSNK1G10.62434570
88SGK10.62214734
89PBK0.61219358
90CAMK10.60882087
91ROCK10.59583425
92MET0.59561367
93SGK30.58837054
94CDK30.54543499
95TNK20.53577640
96PRKCQ0.53570577
97TSSK60.53390611
98CAMKK20.52853881
99ERBB30.50537063
100PDK10.48890616
101TRIM280.48006013
102MAPK100.47946557
103RPS6KA30.47492678
104MAPKAPK50.47404326
105LIMK10.46821397
106PRKD20.45081344
107BMX0.43264762
108PRKG10.42772088
109RET0.42589149
110SIK20.42236667
111MKNK20.42152028
112PTK2B0.41911176
113DDR20.41146303
114PRKCZ0.40861201
115CDC42BPA0.39637946
116CSNK1A10.39385627
117CLK10.39171500
118MKNK10.37538029
119BRSK10.35130217
120ADRBK20.34619405
121DYRK30.32527828
122PRKACA0.30407689
123CSNK1D0.28294441
124INSRR0.27685034
125CAMK40.27511485
126WEE10.25865215
127AKT20.25532880
128NEK90.24765430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.39716155
2Nicotine addiction_Homo sapiens_hsa050333.25395962
3GABAergic synapse_Homo sapiens_hsa047272.82216746
4Glutamatergic synapse_Homo sapiens_hsa047242.64886615
5Synaptic vesicle cycle_Homo sapiens_hsa047212.44705023
6Morphine addiction_Homo sapiens_hsa050322.39301308
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.37845957
8Circadian entrainment_Homo sapiens_hsa047132.28562120
9Olfactory transduction_Homo sapiens_hsa047402.20886183
10Salivary secretion_Homo sapiens_hsa049702.09547860
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.93371473
12Long-term potentiation_Homo sapiens_hsa047201.88067466
13Gastric acid secretion_Homo sapiens_hsa049711.82367072
14Insulin secretion_Homo sapiens_hsa049111.78712276
15Amphetamine addiction_Homo sapiens_hsa050311.78221912
16Dopaminergic synapse_Homo sapiens_hsa047281.69381715
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67819859
18Serotonergic synapse_Homo sapiens_hsa047261.64323975
19Cholinergic synapse_Homo sapiens_hsa047251.61048221
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60710465
21Long-term depression_Homo sapiens_hsa047301.57795734
22Axon guidance_Homo sapiens_hsa043601.57633963
23Basal cell carcinoma_Homo sapiens_hsa052171.56494118
24Cocaine addiction_Homo sapiens_hsa050301.55295647
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49653764
26Renin secretion_Homo sapiens_hsa049241.46357014
27Fatty acid biosynthesis_Homo sapiens_hsa000611.45763445
28Taste transduction_Homo sapiens_hsa047421.41358644
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.36260736
30Calcium signaling pathway_Homo sapiens_hsa040201.34443754
31Steroid biosynthesis_Homo sapiens_hsa001001.34068305
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32212077
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.31230528
34Hippo signaling pathway_Homo sapiens_hsa043901.30743946
35Notch signaling pathway_Homo sapiens_hsa043301.29783307
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28641614
37Phototransduction_Homo sapiens_hsa047441.25970826
38Oxytocin signaling pathway_Homo sapiens_hsa049211.25656370
39Vitamin B6 metabolism_Homo sapiens_hsa007501.23059099
40cAMP signaling pathway_Homo sapiens_hsa040241.23012799
41Dorso-ventral axis formation_Homo sapiens_hsa043201.20874541
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19439729
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17440763
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16212076
45Arginine and proline metabolism_Homo sapiens_hsa003301.15791328
46Ether lipid metabolism_Homo sapiens_hsa005651.15019384
47Gap junction_Homo sapiens_hsa045401.13584931
48Propanoate metabolism_Homo sapiens_hsa006401.13021801
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12608976
50Pancreatic secretion_Homo sapiens_hsa049721.11312566
51Phospholipase D signaling pathway_Homo sapiens_hsa040721.08882971
52Cardiac muscle contraction_Homo sapiens_hsa042601.04421208
53beta-Alanine metabolism_Homo sapiens_hsa004101.02992958
54Fatty acid elongation_Homo sapiens_hsa000621.01857012
55GnRH signaling pathway_Homo sapiens_hsa049120.99934052
56Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99551663
57Collecting duct acid secretion_Homo sapiens_hsa049660.98582186
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93643346
59Melanogenesis_Homo sapiens_hsa049160.90692016
60ErbB signaling pathway_Homo sapiens_hsa040120.89832489
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89469477
62Sulfur relay system_Homo sapiens_hsa041220.87997712
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.87668750
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85934586
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85098238
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.81203675
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81010827
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80573628
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80473576
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74725904
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74148137
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73998204
73Peroxisome_Homo sapiens_hsa041460.73469225
74Thyroid hormone synthesis_Homo sapiens_hsa049180.73098924
75Estrogen signaling pathway_Homo sapiens_hsa049150.73012944
76Choline metabolism in cancer_Homo sapiens_hsa052310.72870128
77Bile secretion_Homo sapiens_hsa049760.72179073
78Butanoate metabolism_Homo sapiens_hsa006500.71961835
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.70291681
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68423459
81Ras signaling pathway_Homo sapiens_hsa040140.67298834
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66424241
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65616541
84Mineral absorption_Homo sapiens_hsa049780.65403003
85Sphingolipid metabolism_Homo sapiens_hsa006000.65332452
86Renal cell carcinoma_Homo sapiens_hsa052110.65163887
87Dilated cardiomyopathy_Homo sapiens_hsa054140.64540787
88Vibrio cholerae infection_Homo sapiens_hsa051100.63871242
89Type II diabetes mellitus_Homo sapiens_hsa049300.63309914
90Histidine metabolism_Homo sapiens_hsa003400.62193074
91Parkinsons disease_Homo sapiens_hsa050120.62030940
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61017231
93Glioma_Homo sapiens_hsa052140.59965888
94Circadian rhythm_Homo sapiens_hsa047100.59537135
95Oxidative phosphorylation_Homo sapiens_hsa001900.58742962
96Endocytosis_Homo sapiens_hsa041440.58433704
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.55494015
98MAPK signaling pathway_Homo sapiens_hsa040100.55471470
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54822313
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53817557
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53506974
102PPAR signaling pathway_Homo sapiens_hsa033200.53168259
103Hedgehog signaling pathway_Homo sapiens_hsa043400.52793252
104Ovarian steroidogenesis_Homo sapiens_hsa049130.50842089
105Primary bile acid biosynthesis_Homo sapiens_hsa001200.50707032
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49029807
107Fatty acid metabolism_Homo sapiens_hsa012120.49002490
108Rap1 signaling pathway_Homo sapiens_hsa040150.47815655
109Wnt signaling pathway_Homo sapiens_hsa043100.46846044
110Alcoholism_Homo sapiens_hsa050340.45814894
111Biosynthesis of amino acids_Homo sapiens_hsa012300.45166048
112Tight junction_Homo sapiens_hsa045300.45082342
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44706390
114Folate biosynthesis_Homo sapiens_hsa007900.43920268
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.42691766
116Huntingtons disease_Homo sapiens_hsa050160.41347659
117Lysine degradation_Homo sapiens_hsa003100.39960956
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38142125
119Inositol phosphate metabolism_Homo sapiens_hsa005620.37700733
120Oocyte meiosis_Homo sapiens_hsa041140.37555583
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37180246
122Alzheimers disease_Homo sapiens_hsa050100.36581850
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33603205
124Prion diseases_Homo sapiens_hsa050200.31367592
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31064710
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27764279

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