TTYH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tweety family of proteins. Members of this family function as chloride anion channels. The encoded protein functions as a calcium(2+)-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.13301980
2central nervous system myelination (GO:0022010)9.13301980
3fatty acid elongation (GO:0030497)6.28728068
4myelin maintenance (GO:0043217)5.44276250
5synaptic vesicle maturation (GO:0016188)5.44220153
6cellular potassium ion homeostasis (GO:0030007)5.24390564
7sodium ion export (GO:0071436)5.10684257
8synaptic vesicle docking involved in exocytosis (GO:0016081)4.88342652
9synaptic vesicle exocytosis (GO:0016079)4.87522971
10ensheathment of neurons (GO:0007272)4.86064203
11axon ensheathment (GO:0008366)4.86064203
12myelination (GO:0042552)4.85446703
13response to lipoprotein particle (GO:0055094)4.68753012
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.67936143
15L-phenylalanine catabolic process (GO:0006559)4.67936143
16response to redox state (GO:0051775)4.66973109
17locomotory exploration behavior (GO:0035641)4.65769991
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.63925686
19glutamate secretion (GO:0014047)4.61903681
20regulation of synaptic vesicle exocytosis (GO:2000300)4.56976109
21potassium ion import (GO:0010107)4.44246683
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.11539767
23neuronal ion channel clustering (GO:0045161)4.08248709
24postsynaptic membrane organization (GO:0001941)4.04769188
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.03633950
26L-phenylalanine metabolic process (GO:0006558)4.03633950
27potassium ion homeostasis (GO:0055075)3.98329014
28regulation of synaptic vesicle transport (GO:1902803)3.91870318
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.88648811
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83561536
31long-chain fatty acid biosynthetic process (GO:0042759)3.82472278
32cerebellar granule cell differentiation (GO:0021707)3.80020472
33cholesterol biosynthetic process (GO:0006695)3.79885385
34regulation of neuronal synaptic plasticity (GO:0048168)3.78364180
35oligodendrocyte differentiation (GO:0048709)3.77900448
36amyloid precursor protein catabolic process (GO:0042987)3.77884427
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72422835
38very long-chain fatty acid metabolic process (GO:0000038)3.67237824
39negative regulation of neurotransmitter secretion (GO:0046929)3.64549200
40amyloid precursor protein metabolic process (GO:0042982)3.59909815
41regulation of synapse structural plasticity (GO:0051823)3.58590656
42negative regulation of execution phase of apoptosis (GO:1900118)3.57880535
43eye photoreceptor cell differentiation (GO:0001754)3.57642061
44photoreceptor cell differentiation (GO:0046530)3.57642061
45fatty-acyl-CoA biosynthetic process (GO:0046949)3.56705755
46creatine metabolic process (GO:0006600)3.55436743
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.54991055
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.52584053
49exploration behavior (GO:0035640)3.51249652
50neurotransmitter secretion (GO:0007269)3.50381801
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48453476
52import into cell (GO:0098657)3.47429394
53regulation of ARF protein signal transduction (GO:0032012)3.46712341
54neuromuscular process controlling balance (GO:0050885)3.43292923
55neurotransmitter uptake (GO:0001504)3.40310464
56presynaptic membrane assembly (GO:0097105)3.39730164
57response to methylmercury (GO:0051597)3.38008170
58regulation of cholesterol esterification (GO:0010872)3.37570686
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.36826705
60sterol biosynthetic process (GO:0016126)3.35009597
61regulation of lipoprotein metabolic process (GO:0050746)3.31687141
62neuron cell-cell adhesion (GO:0007158)3.30583875
63negative regulation of inclusion body assembly (GO:0090084)3.29907690
64astrocyte differentiation (GO:0048708)3.25397843
65long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.24333253
66regulation of long-term neuronal synaptic plasticity (GO:0048169)3.24014512
67negative regulation of neurotransmitter transport (GO:0051589)3.23800958
68neurotransmitter-gated ion channel clustering (GO:0072578)3.23791029
69regulation of glutamate receptor signaling pathway (GO:1900449)3.23417500
70cell communication by electrical coupling (GO:0010644)3.21810677
71positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.21058340
72nucleotide transmembrane transport (GO:1901679)3.16598890
73negative regulation of protein localization to cell surface (GO:2000009)3.16406212
74acidic amino acid transport (GO:0015800)3.14935552
75cellular sodium ion homeostasis (GO:0006883)3.12503403
76positive regulation of Rap GTPase activity (GO:0032854)3.11951802
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.11542679
78signal peptide processing (GO:0006465)3.11036549
79adenosine receptor signaling pathway (GO:0001973)3.10906276
80regulation of cholesterol biosynthetic process (GO:0045540)3.10324092
81regulation of synaptic plasticity (GO:0048167)3.07421413
82neuronal action potential propagation (GO:0019227)3.07067703
83vocalization behavior (GO:0071625)3.05661540
84L-amino acid import (GO:0043092)3.04270337
85synaptic transmission, glutamatergic (GO:0035249)3.03489855
86fatty-acyl-CoA metabolic process (GO:0035337)3.02776843
87regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.99538443
88aromatic amino acid family catabolic process (GO:0009074)2.99422320
89positive regulation of synapse maturation (GO:0090129)2.98070030
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96185669
91polyol transport (GO:0015791)2.96050428
92peptidyl-tyrosine autophosphorylation (GO:0038083)2.95593358
93low-density lipoprotein particle remodeling (GO:0034374)2.95411200
94neurotransmitter transport (GO:0006836)2.94771784
95regulation of neurotransmitter secretion (GO:0046928)2.94570015
96auditory behavior (GO:0031223)2.93455607
97presynaptic membrane organization (GO:0097090)2.93447273
98long-term synaptic potentiation (GO:0060291)2.92357534
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.91855931
100glycerophospholipid catabolic process (GO:0046475)2.91638046
101cholesterol efflux (GO:0033344)2.90965387
102positive regulation of macrophage cytokine production (GO:0060907)2.89576649
103dendritic spine morphogenesis (GO:0060997)2.89233319
104cerebellar Purkinje cell differentiation (GO:0021702)2.87987241
105omega-hydroxylase P450 pathway (GO:0097267)2.87531393
106positive regulation of dendritic spine development (GO:0060999)2.87332814
107activation of protein kinase A activity (GO:0034199)2.87257430
108regulation of Rap GTPase activity (GO:0032317)2.85771893
109regulation of voltage-gated calcium channel activity (GO:1901385)2.84791908
110response to auditory stimulus (GO:0010996)2.82748799
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.82698730
112L-glutamate transport (GO:0015813)2.80612201
113ER overload response (GO:0006983)2.79821681
114regulation of neurotransmitter transport (GO:0051588)2.79625403
115substantia nigra development (GO:0021762)2.78282972
116astrocyte development (GO:0014002)2.77588474
117nucleotide transport (GO:0006862)2.72831804
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72605439
119regulation of neurotransmitter levels (GO:0001505)2.72563331
120long-term memory (GO:0007616)2.71924866
121regulation of cholesterol metabolic process (GO:0090181)2.70836754
122regulation of collateral sprouting (GO:0048670)2.70107869
123positive regulation of membrane potential (GO:0045838)2.69722027
124synaptic vesicle endocytosis (GO:0048488)2.67036381
125regulation of inclusion body assembly (GO:0090083)2.66804590
126myelination in peripheral nervous system (GO:0022011)2.66162222
127peripheral nervous system axon ensheathment (GO:0032292)2.66162222
128regulation of female receptivity (GO:0045924)2.65259995
129regulation of beta-amyloid formation (GO:1902003)2.65244427
130thioester biosynthetic process (GO:0035384)2.65099417
131acyl-CoA biosynthetic process (GO:0071616)2.65099417
132purine ribonucleotide transport (GO:0015868)2.65040592
133negative regulation of axonogenesis (GO:0050771)2.63332355
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.61189117
135neuron-neuron synaptic transmission (GO:0007270)2.60532539
136high-density lipoprotein particle remodeling (GO:0034375)2.60256475
137apical protein localization (GO:0045176)2.59543685
138negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57416164
139GPI anchor metabolic process (GO:0006505)2.57239820
140regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.57166128
141regulation of synaptic transmission (GO:0050804)2.57077524
142neuromuscular process controlling posture (GO:0050884)2.56724181
143signal complex assembly (GO:0007172)2.56581045
144bile acid biosynthetic process (GO:0006699)2.55914519
145response to lead ion (GO:0010288)2.55402191
146positive regulation of cellular amine metabolic process (GO:0033240)2.54768050
147tyrosine metabolic process (GO:0006570)2.54429131
148heme transport (GO:0015886)2.54425035
149positive regulation of oligodendrocyte differentiation (GO:0048714)2.53827559
150cholesterol metabolic process (GO:0008203)2.53570431
151coenzyme catabolic process (GO:0009109)2.53528488
152asymmetric protein localization (GO:0008105)2.52556009
153positive regulation of neurotransmitter secretion (GO:0001956)2.52503265
154isoprenoid biosynthetic process (GO:0008299)2.52123628
155positive regulation of cellular amide metabolic process (GO:0034250)2.51833390
156layer formation in cerebral cortex (GO:0021819)2.51571968
157peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.51319167
158reverse cholesterol transport (GO:0043691)2.51160320
159glycosylceramide metabolic process (GO:0006677)2.50411858
160purine nucleotide transport (GO:0015865)2.49065452
161amino acid import (GO:0043090)2.47904008
162GPI anchor biosynthetic process (GO:0006506)2.46014476
163very-low-density lipoprotein particle assembly (GO:0034379)2.42905595
164negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.41773332
165establishment of mitochondrion localization (GO:0051654)2.41690153
166glyoxylate metabolic process (GO:0046487)2.41566291
167protein carboxylation (GO:0018214)2.38596645
168peptidyl-glutamic acid carboxylation (GO:0017187)2.38596645
169sterol metabolic process (GO:0016125)2.36766905
170negative regulation of JUN kinase activity (GO:0043508)2.35610168
171bile acid metabolic process (GO:0008206)2.35166337
172L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.34666505
173mannosylation (GO:0097502)2.34374611
174myelin assembly (GO:0032288)2.32873637
175phospholipid efflux (GO:0033700)2.32669199
176cellular response to cholesterol (GO:0071397)2.32562207
177sperm capacitation (GO:0048240)2.31991564
178positive regulation of triglyceride lipase activity (GO:0061365)2.31886970
179positive regulation of lipoprotein lipase activity (GO:0051006)2.31886970
180carbohydrate derivative transport (GO:1901264)2.31831798
181steroid biosynthetic process (GO:0006694)2.30727238
182L-serine metabolic process (GO:0006563)2.29277020
183amino acid salvage (GO:0043102)2.29042403
184L-methionine salvage (GO:0071267)2.29042403
185L-methionine biosynthetic process (GO:0071265)2.29042403
186alpha-linolenic acid metabolic process (GO:0036109)2.28325704
187regulation of bile acid biosynthetic process (GO:0070857)2.26211169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58814080
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.06353885
3* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.77204230
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.64321871
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.55937044
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.49303934
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.39718674
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.38533375
9* RXR_22158963_ChIP-Seq_LIVER_Mouse2.37694654
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.33676280
11GBX2_23144817_ChIP-Seq_PC3_Human2.28758473
12REST_21632747_ChIP-Seq_MESCs_Mouse2.27380114
13SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.18329797
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12454912
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07835077
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.04641248
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02965363
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01747410
19KDM2B_26808549_Chip-Seq_K562_Human2.00360714
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.85902987
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.85191590
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82045734
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79529206
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.74698660
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73870512
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70465967
27AR_21572438_ChIP-Seq_LNCaP_Human1.70264957
28* LXR_22292898_ChIP-Seq_THP-1_Human1.69299884
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65462294
30NRF2_20460467_ChIP-Seq_MEFs_Mouse1.65458686
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.65458686
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.65336335
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62884041
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58782729
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.58438098
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57059287
37KDM2B_26808549_Chip-Seq_DND41_Human1.56185936
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50042655
39* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49555933
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48006259
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.47297373
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.45595653
43SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41775927
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.40456337
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40259421
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39782031
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.38506201
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38264144
49EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.36336231
50* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35726498
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34549977
52RING1B_27294783_Chip-Seq_ESCs_Mouse1.32704306
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31828065
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30459189
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28934161
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27491902
57* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26660492
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26405537
59OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25891862
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25650451
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25026885
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23917767
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23917767
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23665905
65ER_23166858_ChIP-Seq_MCF-7_Human1.23032963
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.21858584
67FOXA2_19822575_ChIP-Seq_HepG2_Human1.20768101
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20243159
69FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20072640
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.19205328
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18437568
72* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17505600
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17028419
74DROSHA_22980978_ChIP-Seq_HELA_Human1.16550874
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.15999602
76SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14548738
77SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14415553
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13571761
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12938609
80JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12387575
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12260613
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11108980
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.11065636
84TCF7_22412390_ChIP-Seq_EML_Mouse1.09847578
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09458908
86STAT3_23295773_ChIP-Seq_U87_Human1.09119898
87CTCF_27219007_Chip-Seq_Bcells_Human1.08029535
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.06953871
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.06837808
90* OCT4_19829295_ChIP-Seq_ESCs_Human1.06442931
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06390374
92P300_18555785_Chip-Seq_ESCs_Mouse1.06299394
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05936856
94KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05826787
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05683853
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04052606
97EZH2_27304074_Chip-Seq_ESCs_Mouse1.03878789
98SMC4_20622854_ChIP-Seq_HELA_Human1.03411277
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02600713
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02123796
101CBP_21632823_ChIP-Seq_H3396_Human1.01920192
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.01070025
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00015576
104EZH2_27294783_Chip-Seq_NPCs_Mouse0.99872524
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99422998
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.99018712
107NANOG_18555785_Chip-Seq_ESCs_Mouse0.98634986
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98574482
109POU3F2_20337985_ChIP-ChIP_501MEL_Human0.97318906
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97067759
111TAF15_26573619_Chip-Seq_HEK293_Human0.96914379
112HTT_18923047_ChIP-ChIP_STHdh_Human0.96690673
113SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96552378
114NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96429545
115EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96339393
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96102811
117STAT3_18555785_Chip-Seq_ESCs_Mouse0.96072849
118KLF4_18555785_Chip-Seq_ESCs_Mouse0.95820229
119NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95431745
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95339111
121AHR_22903824_ChIP-Seq_MCF-7_Human0.95224693
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95204495
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.95201642
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94878626
125SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94294454
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94007154
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93030226
128PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93023290
129ESR2_21235772_ChIP-Seq_MCF-7_Human0.92955069
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92612098
131SCL_19346495_ChIP-Seq_HPC-7_Human0.91998672
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91474070
133JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91014221
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.90742384
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89776298
136TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89768663
137ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89541764
138VDR_21846776_ChIP-Seq_THP-1_Human0.89521189
139SMAD1_18555785_Chip-Seq_ESCs_Mouse0.88667978
140MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88602956
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88252735
142P300_19829295_ChIP-Seq_ESCs_Human0.88247118
143TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87854678
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.87679216
145P53_22387025_ChIP-Seq_ESCs_Mouse0.87248681
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87208457
147PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.86996094
148TBL1_22424771_ChIP-Seq_293T_Human0.86967690
149SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86286077
150SOX2_20726797_ChIP-Seq_SW620_Human0.86232452
151CJUN_26792858_Chip-Seq_BT549_Human0.86075610
152KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86047402
153RUNX1_27457419_Chip-Seq_LIVER_Mouse0.85947064
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.85898688
155E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84994092
156DPY_21335234_ChIP-Seq_ESCs_Mouse0.84453235
157* KLF4_19829295_ChIP-Seq_ESCs_Human0.83845305
158* MITF_21258399_ChIP-Seq_MELANOMA_Human0.83061811
159DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81983250
160SPI1_23127762_ChIP-Seq_K562_Human0.80809794
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.79246061
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78065736
163AR_19668381_ChIP-Seq_PC3_Human0.77743697
164P68_20966046_ChIP-Seq_HELA_Human0.77717739
165SA1_27219007_Chip-Seq_ERYTHROID_Human0.77290334
166EGR1_19032775_ChIP-ChIP_M12_Human0.76779508
167GATA1_26923725_Chip-Seq_HPCs_Mouse0.76531420
168NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.75969566
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75624139
170GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75061518
171TBX20_22328084_ChIP-Seq_HEART_Mouse0.74994704
172TBX20_22080862_ChIP-Seq_HEART_Mouse0.74994704
173CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73348177
174UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72896143
175SMAD4_21741376_ChIP-Seq_ESCs_Human0.72796600

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.30822778
2MP0000920_abnormal_myelination4.42105141
3MP0009840_abnormal_foam_cell4.32547699
4MP0005360_urolithiasis4.01978209
5MP0002139_abnormal_hepatobiliary_system3.62437896
6MP0003195_calcinosis3.50899894
7MP0003635_abnormal_synaptic_transmissio3.29926290
8MP0003950_abnormal_plasma_membrane3.20289309
9MP0003690_abnormal_glial_cell3.16171701
10MP0005171_absent_coat_pigmentation2.89490154
11MP0004043_abnormal_pH_regulation2.70818419
12MP0002063_abnormal_learning/memory/cond2.69076663
13MP0003806_abnormal_nucleotide_metabolis2.68759602
14MP0009745_abnormal_behavioral_response2.59662777
15MP0003136_yellow_coat_color2.56981922
16MP0004885_abnormal_endolymph2.25209786
17MP0003191_abnormal_cellular_cholesterol2.13814622
18MP0005167_abnormal_blood-brain_barrier2.13769733
19MP0005085_abnormal_gallbladder_physiolo2.10452046
20MP0002572_abnormal_emotion/affect_behav2.09832091
21MP0003634_abnormal_glial_cell2.09204824
22MP0008438_abnormal_cutaneous_collagen2.08803162
23MP0003303_peritoneal_inflammation2.02563950
24MP0005365_abnormal_bile_salt1.96752460
25MP0003329_amyloid_beta_deposits1.91911182
26MP0003879_abnormal_hair_cell1.86038013
27MP0001970_abnormal_pain_threshold1.82876655
28MP0001905_abnormal_dopamine_level1.82815281
29MP0009046_muscle_twitch1.82572557
30MP0003075_altered_response_to1.81610784
31MP0002735_abnormal_chemical_nociception1.79570117
32MP0001968_abnormal_touch/_nociception1.78909013
33MP0005058_abnormal_lysosome_morphology1.77996784
34MP0001502_abnormal_circadian_rhythm1.72729621
35MP0001501_abnormal_sleep_pattern1.72419659
36MP0002229_neurodegeneration1.71202365
37MP0005551_abnormal_eye_electrophysiolog1.68070886
38MP0008260_abnormal_autophagy1.63890498
39MP0002733_abnormal_thermal_nociception1.62695651
40MP0005409_darkened_coat_color1.60152245
41MP0005645_abnormal_hypothalamus_physiol1.58287946
42MP0004270_analgesia1.56110857
43MP0005408_hypopigmentation1.54747432
44MP0004742_abnormal_vestibular_system1.49298440
45MP0005332_abnormal_amino_acid1.48235390
46MP0002067_abnormal_sensory_capabilities1.47753833
47MP0001666_abnormal_nutrient_absorption1.47682622
48MP0004811_abnormal_neuron_physiology1.46544527
49MP0003632_abnormal_nervous_system1.46457248
50MP0004381_abnormal_hair_follicle1.42457189
51MP0008875_abnormal_xenobiotic_pharmacok1.42160465
52MP0002118_abnormal_lipid_homeostasis1.38507262
53MP0004142_abnormal_muscle_tone1.37952449
54MP0005410_abnormal_fertilization1.37254962
55MP0003252_abnormal_bile_duct1.34384784
56MP0002272_abnormal_nervous_system1.33325255
57MP0004510_myositis1.31047026
58MP0002877_abnormal_melanocyte_morpholog1.30601398
59MP0002066_abnormal_motor_capabilities/c1.30445417
60MP0001486_abnormal_startle_reflex1.28487918
61MP0000604_amyloidosis1.28191605
62MP0001984_abnormal_olfaction1.25584134
63MP0009278_abnormal_bone_marrow1.24045705
64MP0004134_abnormal_chest_morphology1.21254185
65MP0001440_abnormal_grooming_behavior1.16499626
66MP0003631_nervous_system_phenotype1.16393313
67MP0008874_decreased_physiological_sensi1.14814035
68MP0003172_abnormal_lysosome_physiology1.13080879
69MP0005253_abnormal_eye_physiology1.11698527
70MP0004782_abnormal_surfactant_physiolog1.11256556
71MP0002557_abnormal_social/conspecific_i1.10153471
72MP0001177_atelectasis1.09218748
73MP0002822_catalepsy1.07899158
74MP0003787_abnormal_imprinting1.07466624
75MP0003011_delayed_dark_adaptation1.06634878
76MP0001661_extended_life_span1.05602404
77MP0005166_decreased_susceptibility_to1.05363303
78MP0005670_abnormal_white_adipose1.05327745
79MP0005451_abnormal_body_composition1.04762477
80MP0005195_abnormal_posterior_eye1.03722056
81MP0009780_abnormal_chondrocyte_physiolo1.03107308
82MP0000372_irregular_coat_pigmentation1.02253321
83MP0001346_abnormal_lacrimal_gland1.02021596
84MP0005646_abnormal_pituitary_gland1.01125991
85MP0001299_abnormal_eye_distance/1.00801141
86MP0004130_abnormal_muscle_cell1.00764575
87MP0000647_abnormal_sebaceous_gland0.99635938
88MP0000462_abnormal_digestive_system0.99282109
89MP0003633_abnormal_nervous_system0.99163078
90MP0000747_muscle_weakness0.97193676
91MP0010329_abnormal_lipoprotein_level0.97193576
92MP0000566_synostosis0.95874690
93MP0002736_abnormal_nociception_after0.95505018
94MP0002638_abnormal_pupillary_reflex0.95476200
95MP0004924_abnormal_behavior0.95205368
96MP0005386_behavior/neurological_phenoty0.95205368
97MP0001529_abnormal_vocalization0.94742576
98MP0002152_abnormal_brain_morphology0.94198068
99MP0002295_abnormal_pulmonary_circulatio0.92751748
100MP0003183_abnormal_peptide_metabolism0.92516740
101MP0002090_abnormal_vision0.90661450
102MP0001485_abnormal_pinna_reflex0.90461938
103MP0006276_abnormal_autonomic_nervous0.89322643
104MP0000579_abnormal_nail_morphology0.89046796
105MP0002876_abnormal_thyroid_physiology0.88685365
106MP0001986_abnormal_taste_sensitivity0.87778613
107MP0000778_abnormal_nervous_system0.84403311
108MP0005083_abnormal_biliary_tract0.82503193
109MP0000003_abnormal_adipose_tissue0.79398650
110MP0008569_lethality_at_weaning0.79233214
111MP0005647_abnormal_sex_gland0.77797117
112MP0003724_increased_susceptibility_to0.75254590
113MP0002653_abnormal_ependyma_morphology0.75189864
114MP0001963_abnormal_hearing_physiology0.74132709
115MP0009643_abnormal_urine_homeostasis0.73779049
116MP0000639_abnormal_adrenal_gland0.72468341
117MP0005164_abnormal_response_to0.71554726
118MP0002064_seizures0.71486198
119MP0004019_abnormal_vitamin_homeostasis0.71425384
120MP0006082_CNS_inflammation0.71120340
121MP0002882_abnormal_neuron_morphology0.70831387
122MP0000749_muscle_degeneration0.70104954
123MP0001324_abnormal_eye_pigmentation0.69819340
124MP0002734_abnormal_mechanical_nocicepti0.69217275
125MP0004858_abnormal_nervous_system0.67944453
126MP0003186_abnormal_redox_activity0.67759060
127MP0000383_abnormal_hair_follicle0.66778008
128MP0005535_abnormal_body_temperature0.66445974
129MP0006072_abnormal_retinal_apoptosis0.66161709
130MP0010678_abnormal_skin_adnexa0.65690341
131MP0003880_abnormal_central_pattern0.64344852
132MP0002419_abnormal_innate_immunity0.64128921
133MP0000026_abnormal_inner_ear0.64111163
134MP0003453_abnormal_keratinocyte_physiol0.63964898
135MP0005671_abnormal_response_to0.63877782
136MP0005000_abnormal_immune_tolerance0.63733494
137MP0002752_abnormal_somatic_nervous0.63266664
138MP0000343_altered_response_to0.63260907
139MP0009384_cardiac_valve_regurgitation0.63040961
140MP0005423_abnormal_somatic_nervous0.62811560
141MP0000955_abnormal_spinal_cord0.62591516
142MP0003300_gastrointestinal_ulcer0.62249320
143MP0000609_abnormal_liver_physiology0.62115657
144MP0005379_endocrine/exocrine_gland_phen0.62104934
145MP0001764_abnormal_homeostasis0.62066426
146MP0003436_decreased_susceptibility_to0.61745867
147MP0005025_abnormal_response_to0.60154802
148MP0000751_myopathy0.58368075
149MP0003137_abnormal_impulse_conducting0.52706789
150MP0005174_abnormal_tail_pigmentation0.51169545
151MP0001851_eye_inflammation0.51033835
152MP0002184_abnormal_innervation0.50826981
153MP0003045_fibrosis0.50452635

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.45128308
2Neurofibrillary tangles (HP:0002185)5.27818775
3Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.93186581
4Abnormality of binocular vision (HP:0011514)4.72291738
5Diplopia (HP:0000651)4.72291738
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.61037885
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.61037885
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.48505019
9Focal motor seizures (HP:0011153)4.45908308
10Ankle clonus (HP:0011448)4.40448705
11Action tremor (HP:0002345)4.24597427
12Abnormal auditory evoked potentials (HP:0006958)4.04858784
13Intrahepatic cholestasis (HP:0001406)3.90870038
14Scanning speech (HP:0002168)3.71670949
15Focal seizures (HP:0007359)3.63533076
16Onion bulb formation (HP:0003383)3.62839349
17Segmental peripheral demyelination/remyelination (HP:0003481)3.59562346
18Hemiplegia (HP:0002301)3.53706001
19Mutism (HP:0002300)3.48280668
20Axonal loss (HP:0003447)3.44938641
21Neuronal loss in central nervous system (HP:0002529)3.37506747
22Cerebral inclusion bodies (HP:0100314)3.36482196
23Abnormal eating behavior (HP:0100738)3.33671375
24Obstructive sleep apnea (HP:0002870)3.32420590
25Xanthomatosis (HP:0000991)3.32167885
26Abnormality of the corticospinal tract (HP:0002492)3.23346354
27Postural instability (HP:0002172)3.14611989
28Papilledema (HP:0001085)2.99174237
29Parakeratosis (HP:0001036)2.97619419
30Prolonged neonatal jaundice (HP:0006579)2.97073232
31Epileptic encephalopathy (HP:0200134)2.93122645
32Febrile seizures (HP:0002373)2.89593062
33Supranuclear gaze palsy (HP:0000605)2.89458125
34Symptomatic seizures (HP:0011145)2.84382337
35Prolonged partial thromboplastin time (HP:0003645)2.83550205
36Annular pancreas (HP:0001734)2.82377699
37Hypoglycemic seizures (HP:0002173)2.79232071
38Abolished electroretinogram (ERG) (HP:0000550)2.77576341
39Urinary bladder sphincter dysfunction (HP:0002839)2.69037982
40Generalized tonic-clonic seizures (HP:0002069)2.67688178
41Apathy (HP:0000741)2.67208801
42Epidermoid cyst (HP:0200040)2.65557762
43Rapidly progressive (HP:0003678)2.64429312
44Truncal ataxia (HP:0002078)2.64348070
45Cerebral hypomyelination (HP:0006808)2.63846009
46Hyperlipoproteinemia (HP:0010980)2.62910289
47Atonic seizures (HP:0010819)2.62865181
48Visual hallucinations (HP:0002367)2.62499346
49Peripheral hypomyelination (HP:0007182)2.62462496
50Aplasia involving bones of the upper limbs (HP:0009823)2.61368732
51Aplasia of the phalanges of the hand (HP:0009802)2.61368732
52Aplasia involving bones of the extremities (HP:0009825)2.61368732
53Muscle fiber splitting (HP:0003555)2.61284257
54Abnormality of the periventricular white matter (HP:0002518)2.61225807
55Lower limb muscle weakness (HP:0007340)2.60979940
56Peripheral demyelination (HP:0011096)2.60100044
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.58942763
58Akinesia (HP:0002304)2.58393212
59Paraparesis (HP:0002385)2.55713669
60Hyperinsulinemic hypoglycemia (HP:0000825)2.52761187
61Rigidity (HP:0002063)2.50044253
62Diminished motivation (HP:0000745)2.48698770
63Premature rupture of membranes (HP:0001788)2.48606842
64Hyporeflexia of lower limbs (HP:0002600)2.46109692
65Tetraplegia (HP:0002445)2.44891917
66Intention tremor (HP:0002080)2.42569839
67Pigmentary retinal degeneration (HP:0001146)2.39270936
68Urinary urgency (HP:0000012)2.36144378
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.35825255
70Ocular albinism (HP:0001107)2.33447570
71Torticollis (HP:0000473)2.32686302
72Hemiparesis (HP:0001269)2.29680035
73Depression (HP:0000716)2.29432477
74Hypoglycemic coma (HP:0001325)2.28822553
75Bundle branch block (HP:0011710)2.26235969
76Bowel incontinence (HP:0002607)2.25896401
77Abnormality of glycine metabolism (HP:0010895)2.25511788
78Abnormality of serine family amino acid metabolism (HP:0010894)2.25511788
79Increased corneal curvature (HP:0100692)2.23776362
80Keratoconus (HP:0000563)2.23776362
81Hypokalemic alkalosis (HP:0001949)2.22749928
82Sensory axonal neuropathy (HP:0003390)2.22061077
83Foot dorsiflexor weakness (HP:0009027)2.22038366
84Retinal dysplasia (HP:0007973)2.20943307
85Hepatosplenomegaly (HP:0001433)2.20682267
86Abnormality of methionine metabolism (HP:0010901)2.20661816
87Conjugated hyperbilirubinemia (HP:0002908)2.19994209
88Increased cerebral lipofuscin (HP:0011813)2.18787225
89Dysdiadochokinesis (HP:0002075)2.18557959
90Memory impairment (HP:0002354)2.18151333
91Split foot (HP:0001839)2.17647995
92Insomnia (HP:0100785)2.16482813
93Pheochromocytoma (HP:0002666)2.15362074
94Clonus (HP:0002169)2.15299301
95Progressive neurologic deterioration (HP:0002344)2.13993062
96Hypophosphatemic rickets (HP:0004912)2.13832221
97Abnormal large intestine physiology (HP:0012700)2.13338105
98Fat malabsorption (HP:0002630)2.13133639
99Spastic paraparesis (HP:0002313)2.12679747
100Iris hypopigmentation (HP:0007730)2.11058136
101Premature skin wrinkling (HP:0100678)2.10201541
102Clumsiness (HP:0002312)2.09802933
103Thickened helices (HP:0000391)2.09448271
104Anomalous pulmonary venous return (HP:0010772)2.09230393
105Polyphagia (HP:0002591)2.08408128
106Abnormality of the foot musculature (HP:0001436)2.08266398
107Metabolic alkalosis (HP:0200114)2.07917244
108Bradykinesia (HP:0002067)2.07324268
109Fetal akinesia sequence (HP:0001989)2.06886743
110Progressive cerebellar ataxia (HP:0002073)2.06025824
111Dysostosis multiplex (HP:0000943)2.04973541
112Stereotypic behavior (HP:0000733)2.04181713
113Stridor (HP:0010307)2.04178048
114Choreoathetosis (HP:0001266)2.03670813
115Dementia (HP:0000726)2.01829497
116Termporal pattern (HP:0011008)2.01317666
117Insidious onset (HP:0003587)2.01317666
118Impaired vibration sensation in the lower limbs (HP:0002166)2.00208749
119Difficulty running (HP:0009046)1.99372547
120Vacuolated lymphocytes (HP:0001922)1.98688219
121Slow saccadic eye movements (HP:0000514)1.98067054
122Decreased motor nerve conduction velocity (HP:0003431)1.97938224
123Megalencephaly (HP:0001355)1.97536503
124Spastic tetraparesis (HP:0001285)1.97353794
125Protuberant abdomen (HP:0001538)1.96402238
126Focal dystonia (HP:0004373)1.96358128
127Abnormality of glycolipid metabolism (HP:0010969)1.96130194
128Abnormality of liposaccharide metabolism (HP:0010968)1.96130194
129Abnormality of glycosphingolipid metabolism (HP:0004343)1.96130194
130Patchy hypopigmentation of hair (HP:0011365)1.95753654
131White forelock (HP:0002211)1.95507547
132Sleep apnea (HP:0010535)1.94074545
133Ventricular fibrillation (HP:0001663)1.93615610
134Joint hemorrhage (HP:0005261)1.92022832
135Pancreatic islet-cell hyperplasia (HP:0004510)1.91029421
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90789140
137Deep venous thrombosis (HP:0002625)1.90020616
138Delusions (HP:0000746)1.89725122
139Craniofacial dystonia (HP:0012179)1.88006235
140Global brain atrophy (HP:0002283)1.87764242
141Increased circulating renin level (HP:0000848)1.87424616
142Urinary incontinence (HP:0000020)1.86603369
143Limb dystonia (HP:0002451)1.86187397
144Hypomagnesemia (HP:0002917)1.85422580
145Increased neuronal autofluorescent lipopigment (HP:0002074)1.85374568
146Abnormality of monocarboxylic acid metabolism (HP:0010996)1.84527885
147Heart block (HP:0012722)1.84381080
148Turricephaly (HP:0000262)1.83084194
149Hypoplasia of the iris (HP:0007676)1.82626780
150Dysmetria (HP:0001310)1.82489622
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82442775
152Hyperglycinuria (HP:0003108)1.81854797
153Absence seizures (HP:0002121)1.81553049
154Morphological abnormality of the inner ear (HP:0011390)1.81493368
155Amyotrophic lateral sclerosis (HP:0007354)1.80486577
156Spastic paraplegia (HP:0001258)1.80122822
157Abnormality of the intrinsic pathway (HP:0010989)1.79111893
158Submucous cleft hard palate (HP:0000176)1.79083311
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.79015766
160Hypoplasia of the fovea (HP:0007750)1.79015766
161Amyloidosis (HP:0011034)1.78630184
162Leukodystrophy (HP:0002415)1.78213902
163Hyperglycinemia (HP:0002154)1.78148019
164Confusion (HP:0001289)1.77846680
165Septo-optic dysplasia (HP:0100842)1.77669620
166Congenital sensorineural hearing impairment (HP:0008527)1.77509368
167Absent septum pellucidum (HP:0001331)1.77182732
168Rickets (HP:0002748)1.76996445
169Generalized aminoaciduria (HP:0002909)1.76819664
170Alacrima (HP:0000522)1.76230496
171Spastic gait (HP:0002064)1.75792302
172Abnormality of the pulmonary veins (HP:0011718)1.75141691
173Anxiety (HP:0000739)1.75012781
174Congenital ichthyosiform erythroderma (HP:0007431)1.74433662
175Bell-shaped thorax (HP:0001591)1.73969843
176Alkalosis (HP:0001948)1.73146532
177Large for gestational age (HP:0001520)1.72815853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B7.69956607
2STK394.46095973
3NTRK33.73828024
4EPHA43.22305322
5EPHB13.17411857
6NTRK23.09750520
7RIPK42.82818407
8MARK12.81106105
9OXSR12.78773129
10PBK2.31145237
11DAPK22.25830451
12WNK42.25275161
13PKN12.23294875
14TYRO32.12663164
15MAPKAPK52.11314567
16FGFR22.09001583
17INSRR2.02483483
18RIPK11.91078542
19MET1.90301982
20SGK4941.87241625
21SGK2231.87241625
22CAMKK11.81000709
23AKT31.71227871
24BCR1.68991869
25NEK61.68783205
26KSR21.64176254
27MAP3K111.61367981
28YES11.58238112
29MAPK151.56361201
30FES1.48560089
31MAP3K131.46681243
32WNK11.46430549
33CSNK1A1L1.45617437
34BMPR21.41612266
35PINK11.41273313
36MINK11.38849900
37ARAF1.37752420
38GSK3A1.33740965
39UHMK11.29093188
40MAP3K91.17256957
41DYRK21.13432876
42CAMK2B1.12214265
43CAMK2D1.10110301
44IRAK31.09799271
45ROCK21.09474691
46CSNK1G31.08163374
47PHKG11.08026887
48PHKG21.08026887
49LIMK11.05828578
50SIK21.03548941
51NTRK11.02666307
52CLK11.01690868
53CSNK1G10.99463808
54IRAK20.97989940
55PRKD30.97191880
56CAMK10.96768191
57EPHA30.91497641
58CAMK2G0.90956420
59TRPM70.88014747
60MAP3K10.86303859
61TESK20.85523789
62MAP4K10.85276001
63MAPK100.85010080
64MAP3K140.83617653
65CASK0.83105813
66STK110.81928921
67PRKCE0.81728681
68CDK150.78421726
69JAK20.78231931
70PDK10.77162020
71GRK10.76791126
72KSR10.76661582
73MOS0.75131468
74MAPK130.74989742
75MAPK70.73978401
76CDK11A0.73863193
77CDK190.71328123
78PRKCH0.71140877
79CDK180.70338586
80FYN0.69819249
81MUSK0.69234967
82GRK50.68856644
83BLK0.67556336
84CDK140.66314512
85ALK0.65818443
86CSNK1G20.65270267
87IRAK10.64407246
88TNIK0.64303456
89PIK3CA0.64222698
90CAMK40.62402949
91BCKDK0.61979809
92FRK0.60495962
93CSNK1A10.60231435
94PAK60.59799886
95RET0.58699155
96ERBB40.58659418
97MKNK10.58353128
98LATS20.58105295
99ICK0.57799027
100CDK50.57369585
101IRAK40.57320925
102CAMK2A0.56798310
103JAK10.56708879
104MAPK40.55574395
105PRKD10.55507411
106PRKCQ0.55465439
107PAK30.55439838
108PLK20.54549410
109TYK20.54030958
110SIK10.53971739
111PRKCG0.53652548
112MAP3K20.53493829
113TRIB30.51177174
114SYK0.51074024
115TAOK20.50588049
116MAP2K20.50522266
117BMPR1B0.48998704
118SGK30.46549267
119RAF10.46465253
120CAMK1G0.46028314
121RPS6KA30.45604098
122ZAP700.45036364
123CAMK1D0.44805848
124HIPK20.44432359
125MKNK20.43724717
126CAMKK20.43673286
127PRKACB0.43300212
128SGK20.41721484
129FGR0.41682724
130ROCK10.41636171
131PRKG10.40694353
132DYRK1A0.40605937
133DAPK30.39358911
134MAPK120.38233409
135INSR0.38190229
136PDGFRA0.38062361
137PRKCZ0.37841160
138TNK20.37601191
139PRKG20.35161002
140DDR20.34954413
141CDC42BPA0.34282922
142ITK0.33696988
143SGK10.33660745
144PRKACA0.33270056
145MST40.33025665
146PRKAA10.32614723
147PDPK10.32533007
148WNK30.31974474
149DYRK1B0.31141610
150PRKAA20.29763342
151CSK0.29731186
152CDK30.29578070
153CSNK1D0.29399008
154ZAK0.29085833
155ERBB20.28869359
156MARK20.28436455
157PRKACG0.27997475
158BMX0.27366424

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001003.94297367
2Fatty acid elongation_Homo sapiens_hsa000623.85412489
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.60510360
4Vitamin B6 metabolism_Homo sapiens_hsa007503.24111845
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.17322435
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.96122774
7Nitrogen metabolism_Homo sapiens_hsa009102.88022734
8Sulfur metabolism_Homo sapiens_hsa009202.83654002
9Synaptic vesicle cycle_Homo sapiens_hsa047212.67713898
10Histidine metabolism_Homo sapiens_hsa003402.46022141
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.45355362
12Nicotine addiction_Homo sapiens_hsa050332.29571808
13Long-term potentiation_Homo sapiens_hsa047202.26535711
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.25982712
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15283963
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13938365
17Circadian entrainment_Homo sapiens_hsa047132.13799502
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09101245
19Protein export_Homo sapiens_hsa030602.01503173
20Morphine addiction_Homo sapiens_hsa050322.00612566
21Ether lipid metabolism_Homo sapiens_hsa005651.95393811
22Gastric acid secretion_Homo sapiens_hsa049711.94835163
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88980240
24Insulin secretion_Homo sapiens_hsa049111.81694486
25Amphetamine addiction_Homo sapiens_hsa050311.80406732
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79399277
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73668023
28Sphingolipid metabolism_Homo sapiens_hsa006001.66778254
29Folate biosynthesis_Homo sapiens_hsa007901.61179576
30Butanoate metabolism_Homo sapiens_hsa006501.60162296
31Vitamin digestion and absorption_Homo sapiens_hsa049771.55655632
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54930511
33Peroxisome_Homo sapiens_hsa041461.52857249
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51002509
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.46236641
36Cholinergic synapse_Homo sapiens_hsa047251.44850594
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44233861
38Arginine and proline metabolism_Homo sapiens_hsa003301.42783335
39Fatty acid metabolism_Homo sapiens_hsa012121.41547928
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.40651601
41Dopaminergic synapse_Homo sapiens_hsa047281.39821070
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.37982654
43Renin secretion_Homo sapiens_hsa049241.36075352
44Oxytocin signaling pathway_Homo sapiens_hsa049211.35234116
45Estrogen signaling pathway_Homo sapiens_hsa049151.34781667
46Salivary secretion_Homo sapiens_hsa049701.33297783
47cAMP signaling pathway_Homo sapiens_hsa040241.31374740
48Lysosome_Homo sapiens_hsa041421.30016330
49GnRH signaling pathway_Homo sapiens_hsa049121.29830669
50beta-Alanine metabolism_Homo sapiens_hsa004101.25251961
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22882346
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22288738
53Linoleic acid metabolism_Homo sapiens_hsa005911.21030557
54Tryptophan metabolism_Homo sapiens_hsa003801.20867249
55Complement and coagulation cascades_Homo sapiens_hsa046101.19061782
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17957279
57PPAR signaling pathway_Homo sapiens_hsa033201.17323092
58Osteoclast differentiation_Homo sapiens_hsa043801.16385723
59Retinol metabolism_Homo sapiens_hsa008301.15733572
60Propanoate metabolism_Homo sapiens_hsa006401.15561994
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15378317
62Calcium signaling pathway_Homo sapiens_hsa040201.14349216
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12845442
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12633410
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.10669374
66Fatty acid degradation_Homo sapiens_hsa000711.10272925
67Arginine biosynthesis_Homo sapiens_hsa002201.09294359
68Glioma_Homo sapiens_hsa052141.09217114
69ABC transporters_Homo sapiens_hsa020101.09013909
70Long-term depression_Homo sapiens_hsa047301.02514086
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02245605
72SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01553904
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00651703
74ErbB signaling pathway_Homo sapiens_hsa040120.98933229
75Gap junction_Homo sapiens_hsa045400.98107317
76VEGF signaling pathway_Homo sapiens_hsa043700.97251233
77Chemical carcinogenesis_Homo sapiens_hsa052040.95697706
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95184513
79Leishmaniasis_Homo sapiens_hsa051400.93469152
80Notch signaling pathway_Homo sapiens_hsa043300.92828038
81Arachidonic acid metabolism_Homo sapiens_hsa005900.91156882
82Melanogenesis_Homo sapiens_hsa049160.90391290
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90018625
84Tyrosine metabolism_Homo sapiens_hsa003500.89385939
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87989142
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87108649
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85766731
88MAPK signaling pathway_Homo sapiens_hsa040100.85194635
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85166673
90Rap1 signaling pathway_Homo sapiens_hsa040150.84458764
91Endocytosis_Homo sapiens_hsa041440.83853842
92Mineral absorption_Homo sapiens_hsa049780.83573448
93Tuberculosis_Homo sapiens_hsa051520.83317740
94Chemokine signaling pathway_Homo sapiens_hsa040620.82427311
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.82236844
96Dorso-ventral axis formation_Homo sapiens_hsa043200.82118406
97Pancreatic secretion_Homo sapiens_hsa049720.81548938
98Fat digestion and absorption_Homo sapiens_hsa049750.77541350
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76898729
100Choline metabolism in cancer_Homo sapiens_hsa052310.76277488
101B cell receptor signaling pathway_Homo sapiens_hsa046620.76024594
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75089146
103Olfactory transduction_Homo sapiens_hsa047400.74647571
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72514245
105Bile secretion_Homo sapiens_hsa049760.70886978
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70437440
107Staphylococcus aureus infection_Homo sapiens_hsa051500.70052679
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.69652676
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.69378877
110African trypanosomiasis_Homo sapiens_hsa051430.69051628
111Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66659353
112Glutathione metabolism_Homo sapiens_hsa004800.65522649
113Type II diabetes mellitus_Homo sapiens_hsa049300.64019983
114Thyroid hormone synthesis_Homo sapiens_hsa049180.63681213
115Fatty acid biosynthesis_Homo sapiens_hsa000610.62042232
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58977798
117Phenylalanine metabolism_Homo sapiens_hsa003600.58924521
118Renal cell carcinoma_Homo sapiens_hsa052110.58878718
119Ovarian steroidogenesis_Homo sapiens_hsa049130.58219682
120Dilated cardiomyopathy_Homo sapiens_hsa054140.57408644
121Taste transduction_Homo sapiens_hsa047420.56499424
122Endometrial cancer_Homo sapiens_hsa052130.56490414
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56241693
124Vibrio cholerae infection_Homo sapiens_hsa051100.56155984
125Salmonella infection_Homo sapiens_hsa051320.55770140
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55758652
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55073354
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53976170
129Pertussis_Homo sapiens_hsa051330.53693801
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.52475101
131Toxoplasmosis_Homo sapiens_hsa051450.52320232
132Metabolic pathways_Homo sapiens_hsa011000.52212469
133Selenocompound metabolism_Homo sapiens_hsa004500.51892050
134Non-small cell lung cancer_Homo sapiens_hsa052230.51343184
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50993529
136Allograft rejection_Homo sapiens_hsa053300.50354991
137Phototransduction_Homo sapiens_hsa047440.50352762
138Prion diseases_Homo sapiens_hsa050200.49707754
139Other glycan degradation_Homo sapiens_hsa005110.49124012
140Cardiac muscle contraction_Homo sapiens_hsa042600.49107182
141mTOR signaling pathway_Homo sapiens_hsa041500.48252258
142Starch and sucrose metabolism_Homo sapiens_hsa005000.47540779
143T cell receptor signaling pathway_Homo sapiens_hsa046600.44658466
144Phagosome_Homo sapiens_hsa041450.44071704
145GABAergic synapse_Homo sapiens_hsa047270.43930846
146Axon guidance_Homo sapiens_hsa043600.43830864
147Glycerolipid metabolism_Homo sapiens_hsa005610.43539562
148Regulation of autophagy_Homo sapiens_hsa041400.41554343
149Rheumatoid arthritis_Homo sapiens_hsa053230.40671999
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32591284
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31949524
152Cocaine addiction_Homo sapiens_hsa050300.31660927
153Cysteine and methionine metabolism_Homo sapiens_hsa002700.30733970
154Serotonergic synapse_Homo sapiens_hsa047260.28379580
155Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25836561
156Sphingolipid signaling pathway_Homo sapiens_hsa040710.25249259
157Tight junction_Homo sapiens_hsa045300.24907052
158Collecting duct acid secretion_Homo sapiens_hsa049660.24517306
159Circadian rhythm_Homo sapiens_hsa047100.22586783
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20704851
161Inositol phosphate metabolism_Homo sapiens_hsa005620.20605891
162Drug metabolism - other enzymes_Homo sapiens_hsa009830.19957137
163Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19024791
164Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17699804
165Autoimmune thyroid disease_Homo sapiens_hsa053200.16883049
166ECM-receptor interaction_Homo sapiens_hsa045120.16265610
167Malaria_Homo sapiens_hsa051440.15878953
168Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15822981
169Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15242684
170Ras signaling pathway_Homo sapiens_hsa040140.15098664
171Protein digestion and absorption_Homo sapiens_hsa049740.13936180
172Glutamatergic synapse_Homo sapiens_hsa047240.13851312
173Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13270467
174Pyruvate metabolism_Homo sapiens_hsa006200.12139155

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