TUBA1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)8.28671871
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.97706273
3protein localization to kinetochore (GO:0034501)4.81863752
4cotranslational protein targeting to membrane (GO:0006613)4.73955558
5ATP synthesis coupled proton transport (GO:0015986)4.73234370
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.73234370
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.72239571
8protein targeting to ER (GO:0045047)4.61121330
9cellular protein complex disassembly (GO:0043624)4.56145633
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.40311321
11establishment of protein localization to mitochondrial membrane (GO:0090151)4.35020076
12dopaminergic neuron differentiation (GO:0071542)4.34535078
13protein localization to endoplasmic reticulum (GO:0070972)4.26950017
14viral life cycle (GO:0019058)4.25115609
15primitive streak formation (GO:0090009)4.22918859
16microtubule depolymerization (GO:0007019)4.13057876
17formation of translation preinitiation complex (GO:0001731)4.08748575
18protein localization to chromosome, centromeric region (GO:0071459)4.04228472
19protein complex disassembly (GO:0043241)3.99685260
20positive regulation of gastrulation (GO:2000543)3.93891904
21mitotic sister chromatid segregation (GO:0000070)3.89491046
22mitotic metaphase plate congression (GO:0007080)3.86672630
23establishment of integrated proviral latency (GO:0075713)3.85506247
24mitotic nuclear envelope disassembly (GO:0007077)3.82433035
25macromolecular complex disassembly (GO:0032984)3.81799591
26regulation of spindle organization (GO:0090224)3.78775323
27nuclear envelope disassembly (GO:0051081)3.52829746
28membrane disassembly (GO:0030397)3.52829746
29midbrain development (GO:0030901)3.49972334
30folic acid-containing compound biosynthetic process (GO:0009396)3.49522869
31DNA damage response, detection of DNA damage (GO:0042769)3.48596039
32sister chromatid segregation (GO:0000819)3.46879355
33respiratory electron transport chain (GO:0022904)3.43129926
34inner mitochondrial membrane organization (GO:0007007)3.35707271
35electron transport chain (GO:0022900)3.35135048
36ribosomal small subunit assembly (GO:0000028)3.33628205
37DNA strand elongation involved in DNA replication (GO:0006271)3.28572156
38maturation of SSU-rRNA (GO:0030490)3.28142632
39nuclear pore organization (GO:0006999)3.25780558
40regulation of mitotic spindle organization (GO:0060236)3.25568627
41DNA unwinding involved in DNA replication (GO:0006268)3.25150734
42mitotic chromosome condensation (GO:0007076)3.24580174
43metaphase plate congression (GO:0051310)3.23763984
44DNA replication initiation (GO:0006270)3.22593709
45establishment of chromosome localization (GO:0051303)3.20171111
46nuclear pore complex assembly (GO:0051292)3.17740938
47attachment of spindle microtubules to kinetochore (GO:0008608)3.16733535
48translation (GO:0006412)3.16657937
49protein targeting to membrane (GO:0006612)3.12219078
50neuron fate determination (GO:0048664)3.11381787
51nucleobase biosynthetic process (GO:0046112)3.11060958
52DNA strand elongation (GO:0022616)3.09695103
53negative regulation of microtubule polymerization (GO:0031115)3.08124229
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.07571735
55protein localization to microtubule (GO:0035372)3.02085302
56telomere maintenance via semi-conservative replication (GO:0032201)3.01545482
57DNA replication-dependent nucleosome assembly (GO:0006335)2.99389897
58DNA replication-dependent nucleosome organization (GO:0034723)2.99389897
59kinetochore organization (GO:0051383)2.97288216
60mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96403995
61nuclear-transcribed mRNA catabolic process (GO:0000956)2.94124547
62IMP biosynthetic process (GO:0006188)2.93892230
63ribosome assembly (GO:0042255)2.91860296
64DNA replication checkpoint (GO:0000076)2.90646246
65CENP-A containing nucleosome assembly (GO:0034080)2.88959513
66protein K6-linked ubiquitination (GO:0085020)2.88446502
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.86521689
68negative regulation of ligase activity (GO:0051352)2.86521689
69regulation of gene silencing by RNA (GO:0060966)2.85376920
70regulation of posttranscriptional gene silencing (GO:0060147)2.85376920
71regulation of gene silencing by miRNA (GO:0060964)2.85376920
72purine nucleobase biosynthetic process (GO:0009113)2.82287538
73chromatin remodeling at centromere (GO:0031055)2.81300853
74mRNA catabolic process (GO:0006402)2.81100982
75spliceosomal snRNP assembly (GO:0000387)2.79109453
76positive regulation of chromosome segregation (GO:0051984)2.77241674
77establishment of viral latency (GO:0019043)2.76987477
78ribosome biogenesis (GO:0042254)2.76101530
79anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75883804
80ribosomal large subunit biogenesis (GO:0042273)2.75820820
81spindle checkpoint (GO:0031577)2.75306015
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.74140584
83nuclear envelope organization (GO:0006998)2.72668234
84protein neddylation (GO:0045116)2.71735028
85interferon-gamma secretion (GO:0072643)2.70968482
86response to insecticide (GO:0017085)2.69919458
87telomere maintenance via recombination (GO:0000722)2.69548898
88viral transcription (GO:0019083)2.68713492
89translational termination (GO:0006415)2.67316773
90IMP metabolic process (GO:0046040)2.66729727
91pore complex assembly (GO:0046931)2.66527052
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65480837
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65480837
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.65480837
95ribonucleoprotein complex biogenesis (GO:0022613)2.65373323
96kinetochore assembly (GO:0051382)2.64659811
97protein localization to chromosome (GO:0034502)2.64184193
98mitotic recombination (GO:0006312)2.62492661
99DNA deamination (GO:0045006)2.62438601
100translational initiation (GO:0006413)2.61378891
101spindle assembly checkpoint (GO:0071173)2.60800213
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60240358
103negative regulation of chromosome segregation (GO:0051985)2.60194718
104regulation of chromosome segregation (GO:0051983)2.59477505
105histone-serine phosphorylation (GO:0035404)2.58147834
106telomere maintenance via telomere lengthening (GO:0010833)2.55519449
107somite rostral/caudal axis specification (GO:0032525)2.55481092
108chromosome segregation (GO:0007059)2.55454220
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.55319891
110negative regulation of sister chromatid segregation (GO:0033046)2.55319891
111negative regulation of mitotic sister chromatid separation (GO:2000816)2.55319891
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.55319891
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.54612455
114ventricular cardiac muscle cell development (GO:0055015)2.54593077
115mitotic spindle assembly checkpoint (GO:0007094)2.54139597
116RNA catabolic process (GO:0006401)2.54064173
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54061905
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53676200
119heterochromatin organization (GO:0070828)2.52304049
120DNA replication-independent nucleosome organization (GO:0034724)2.52284738
121DNA replication-independent nucleosome assembly (GO:0006336)2.52284738
122ribosomal small subunit biogenesis (GO:0042274)2.51390555
123translational elongation (GO:0006414)2.50745467
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.49815622
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49809675
126histone exchange (GO:0043486)2.49248123
127mitotic spindle checkpoint (GO:0071174)2.48151909
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45682826
129T cell apoptotic process (GO:0070231)2.45635789
130rRNA modification (GO:0000154)2.45298818
1317-methylguanosine mRNA capping (GO:0006370)2.44508031
132regulation of telomere maintenance via telomerase (GO:0032210)2.44189108
133DNA geometric change (GO:0032392)2.44110374
134neuron fate specification (GO:0048665)2.42551189
135DNA duplex unwinding (GO:0032508)2.42172965
136regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41668328
137regulation of ubiquitin-protein transferase activity (GO:0051438)2.41562429
138dorsal/ventral neural tube patterning (GO:0021904)2.40512136
139cellular component biogenesis (GO:0044085)2.40441220
140meiotic chromosome segregation (GO:0045132)2.40234503
141chaperone-mediated protein complex assembly (GO:0051131)2.39751293
142positive regulation of ligase activity (GO:0051351)2.39154072
143rRNA processing (GO:0006364)2.38995301
144DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38655419
145proteasome assembly (GO:0043248)2.38272450
146mitotic spindle organization (GO:0007052)2.37555751
147RNA capping (GO:0036260)2.37339954
1487-methylguanosine RNA capping (GO:0009452)2.37339954
149intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36900337
150signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36900337
151signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.36850559
152signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.36850559
153signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.36850559
154G1/S transition of mitotic cell cycle (GO:0000082)2.34456772
155cell cycle G1/S phase transition (GO:0044843)2.34456772
156nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.32880349
157folic acid metabolic process (GO:0046655)2.32459137
158regulation of mitotic sister chromatid separation (GO:0010965)2.31619985
159regulation of mitotic sister chromatid segregation (GO:0033047)2.31619985
160regulation of sister chromatid segregation (GO:0033045)2.31619985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.45274535
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.58284557
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.41113700
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.31616266
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.24339066
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11359914
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.89578967
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.78935198
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.61238193
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44518473
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.31483725
12AR_21909140_ChIP-Seq_LNCAP_Human2.30463729
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27202379
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20468638
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18798319
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15841356
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07615420
18EZH2_22144423_ChIP-Seq_EOC_Human1.98531586
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98273867
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97293598
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.94016204
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92340176
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92218349
24* XRN2_22483619_ChIP-Seq_HELA_Human1.84606320
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.83733191
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.83056253
27HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78122410
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77678347
29GABP_17652178_ChIP-ChIP_JURKAT_Human1.76622282
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76027861
31ZNF263_19887448_ChIP-Seq_K562_Human1.74593611
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73601605
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71604371
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69634010
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68404590
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66934042
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63167747
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.58416970
39* DCP1A_22483619_ChIP-Seq_HELA_Human1.52882039
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.52025592
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48443756
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47637202
43* MYC_22102868_ChIP-Seq_BL_Human1.46735662
44NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45804021
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.42439835
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41625872
47VDR_23849224_ChIP-Seq_CD4+_Human1.41415798
48* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.40752350
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38295251
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.37099176
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36636690
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36636690
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36636690
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35610201
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.33160689
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31389786
57* TTF2_22483619_ChIP-Seq_HELA_Human1.30185939
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27598400
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27224785
60MYC_18940864_ChIP-ChIP_HL60_Human1.25842242
61SOX17_20123909_ChIP-Seq_XEN_Mouse1.25618671
62GABP_19822575_ChIP-Seq_HepG2_Human1.25398284
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23517515
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22268520
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21364137
66* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21164530
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19614953
68ELK1_19687146_ChIP-ChIP_HELA_Human1.19529425
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19440686
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18666800
71FOXP3_21729870_ChIP-Seq_TREG_Human1.18650238
72* TFEB_21752829_ChIP-Seq_HELA_Human1.18299609
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15470376
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15379505
75VDR_21846776_ChIP-Seq_THP-1_Human1.13213769
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13193850
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12979612
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12636807
79CBX2_27304074_Chip-Seq_ESCs_Mouse1.11652568
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.10525107
81ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10246041
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09862569
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08977177
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08684202
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08264766
86KDM5A_27292631_Chip-Seq_BREAST_Human1.07852557
87KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06912134
88MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06051993
89* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05974415
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05830933
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04715603
92SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04659261
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03515321
94* ATF3_27146783_Chip-Seq_COLON_Human1.03405348
95ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03130374
96RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02787068
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02132529
98SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01744320
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00356762
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00076107
101YY1_21170310_ChIP-Seq_MESCs_Mouse0.98999889
102ELK3_25401928_ChIP-Seq_HUVEC_Human0.98840708
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98419024
104HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.97887289
105KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97878075
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97088896
107* SPI1_23547873_ChIP-Seq_NB4_Human0.96997086
108CIITA_25753668_ChIP-Seq_RAJI_Human0.96962286
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.96855867
110SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96117692
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96063594
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94976604
113NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94944354
114* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94054387
115* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93687665
116BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93379739
117IRF8_21731497_ChIP-ChIP_J774_Mouse0.92996299
118TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92647955
119* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91463936
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.90502719
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89678441
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.89215149
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87703370
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87343927
125ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87044110
126* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86586992
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86421157
128SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86142933
129* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86028784
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85905877
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.85557667
132EZH2_27304074_Chip-Seq_ESCs_Mouse0.84940866
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81461111
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.78249704
135GATA1_26923725_Chip-Seq_HPCs_Mouse0.77540060
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75867154
137NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73966431
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73584347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.21898931
2MP0003693_abnormal_embryo_hatching3.87034949
3MP0003111_abnormal_nucleus_morphology3.14521971
4MP0004957_abnormal_blastocyst_morpholog3.01446010
5MP0010352_gastrointestinal_tract_polyps2.78195217
6MP0003077_abnormal_cell_cycle2.74570472
7MP0010094_abnormal_chromosome_stability2.60371788
8MP0008007_abnormal_cellular_replicative2.52559808
9MP0001529_abnormal_vocalization2.48413995
10MP0002938_white_spotting2.41943619
11MP0003705_abnormal_hypodermis_morpholog2.39604505
12MP0010030_abnormal_orbit_morphology2.32218973
13MP0002254_reproductive_system_inflammat2.21948234
14MP0003315_abnormal_perineum_morphology2.20086055
15MP0006292_abnormal_olfactory_placode2.10144005
16MP0003806_abnormal_nucleotide_metabolis1.99911517
17MP0005023_abnormal_wound_healing1.99903424
18MP0003136_yellow_coat_color1.98350245
19MP0008057_abnormal_DNA_replication1.95640858
20MP0003566_abnormal_cell_adhesion1.94484176
21MP0004133_heterotaxia1.92785897
22MP0000537_abnormal_urethra_morphology1.89333694
23MP0001346_abnormal_lacrimal_gland1.88480863
24MP0003283_abnormal_digestive_organ1.87017172
25MP0000569_abnormal_digit_pigmentation1.83183660
26MP0003941_abnormal_skin_development1.74187700
27MP0002234_abnormal_pharynx_morphology1.73577061
28MP0000350_abnormal_cell_proliferation1.71029576
29MP0003937_abnormal_limbs/digits/tail_de1.67463826
30MP0000490_abnormal_crypts_of1.64687172
31MP0008932_abnormal_embryonic_tissue1.62469424
32MP0001730_embryonic_growth_arrest1.61669428
33MP0008058_abnormal_DNA_repair1.59814053
34MP0010307_abnormal_tumor_latency1.59443033
35MP0003786_premature_aging1.57892697
36MP0002697_abnormal_eye_size1.56827669
37MP0000579_abnormal_nail_morphology1.56693730
38MP0003186_abnormal_redox_activity1.56455639
39MP0003436_decreased_susceptibility_to1.56334052
40MP0009053_abnormal_anal_canal1.51513733
41MP0005076_abnormal_cell_differentiation1.46891388
42MP0002396_abnormal_hematopoietic_system1.43544616
43MP0003119_abnormal_digestive_system1.41025520
44MP0003938_abnormal_ear_development1.40525111
45MP0001286_abnormal_eye_development1.39198780
46MP0005397_hematopoietic_system_phenotyp1.39015501
47MP0001545_abnormal_hematopoietic_system1.39015501
48MP0004264_abnormal_extraembryonic_tissu1.36701132
49MP0000858_altered_metastatic_potential1.31644848
50MP0001672_abnormal_embryogenesis/_devel1.30068148
51MP0005380_embryogenesis_phenotype1.30068148
52MP0002877_abnormal_melanocyte_morpholog1.29095663
53MP0003959_abnormal_lean_body1.24865807
54MP0003718_maternal_effect1.24046193
55MP0003453_abnormal_keratinocyte_physiol1.23071378
56MP0002086_abnormal_extraembryonic_tissu1.21286495
57MP0003950_abnormal_plasma_membrane1.20799072
58MP0005187_abnormal_penis_morphology1.20382825
59MP0003984_embryonic_growth_retardation1.19861735
60MP0002019_abnormal_tumor_incidence1.18121357
61MP0002277_abnormal_respiratory_mucosa1.18112253
62MP0000647_abnormal_sebaceous_gland1.17911771
63MP0002088_abnormal_embryonic_growth/wei1.17888581
64MP0002282_abnormal_trachea_morphology1.16947797
65MP0001697_abnormal_embryo_size1.16639808
66MP0000467_abnormal_esophagus_morphology1.13109987
67MP0005197_abnormal_uvea_morphology1.12837649
68MP0009278_abnormal_bone_marrow1.09399033
69MP0002210_abnormal_sex_determination1.09259035
70MP0009250_abnormal_appendicular_skeleto1.09163961
71MP0009840_abnormal_foam_cell1.08451334
72MP0002080_prenatal_lethality1.08450491
73MP0003011_delayed_dark_adaptation1.07832739
74MP0003861_abnormal_nervous_system1.07558900
75MP0004808_abnormal_hematopoietic_stem1.07510999
76MP0009333_abnormal_splenocyte_physiolog1.06104509
77MP0003755_abnormal_palate_morphology1.05574301
78MP0004197_abnormal_fetal_growth/weight/1.05189452
79MP0002822_catalepsy1.05058963
80MP0002751_abnormal_autonomic_nervous1.04830991
81MP0008961_abnormal_basal_metabolism1.04649402
82MP0001293_anophthalmia1.03133683
83MP0000049_abnormal_middle_ear1.02993685
84MP0008995_early_reproductive_senescence1.02855352
85MP0002085_abnormal_embryonic_tissue1.02587016
86MP0002102_abnormal_ear_morphology1.02241388
87MP0000313_abnormal_cell_death1.01533408
88MP0003123_paternal_imprinting1.01503994
89MP0000778_abnormal_nervous_system1.00837594
90MP0008438_abnormal_cutaneous_collagen1.00597780
91MP0001905_abnormal_dopamine_level1.00381879
92MP0002796_impaired_skin_barrier1.00224414
93MP0001853_heart_inflammation0.99323356
94MP0002060_abnormal_skin_morphology0.99084148
95MP0005501_abnormal_skin_physiology0.98914909
96MP0003942_abnormal_urinary_system0.98328168
97MP0002132_abnormal_respiratory_system0.98086460
98MP0000462_abnormal_digestive_system0.97702202
99MP0001849_ear_inflammation0.96961329
100MP0008789_abnormal_olfactory_epithelium0.95764894
101MP0002405_respiratory_system_inflammati0.95011838
102MP0004947_skin_inflammation0.93504319
103MP0001216_abnormal_epidermal_layer0.92617182
104MP0002084_abnormal_developmental_patter0.92301313
105MP0003448_altered_tumor_morphology0.91893458
106MP0005257_abnormal_intraocular_pressure0.90304873
107MP0000534_abnormal_ureter_morphology0.90136129
108MP0010234_abnormal_vibrissa_follicle0.89537057
109MP0003935_abnormal_craniofacial_develop0.88745013
110MP0002098_abnormal_vibrissa_morphology0.88225825
111MP0002111_abnormal_tail_morphology0.87483656
112MP0005275_abnormal_skin_tensile0.86523806
113MP0002736_abnormal_nociception_after0.86142931
114MP0000631_abnormal_neuroendocrine_gland0.86019604
115MP0002233_abnormal_nose_morphology0.84434045
116MP0010155_abnormal_intestine_physiology0.83570399
117MP0002722_abnormal_immune_system0.82556161
118MP0009785_altered_susceptibility_to0.82536720
119MP0003699_abnormal_female_reproductive0.82160098
120MP0000372_irregular_coat_pigmentation0.82009144
121MP0001835_abnormal_antigen_presentation0.81987231
122MP0006035_abnormal_mitochondrial_morpho0.81475795
123MP0003880_abnormal_central_pattern0.81312696
124MP0005499_abnormal_olfactory_system0.80984244
125MP0005394_taste/olfaction_phenotype0.80984244
126MP0000477_abnormal_intestine_morphology0.80393449
127MP0001915_intracranial_hemorrhage0.79484989
128MP0000762_abnormal_tongue_morphology0.79011140
129MP0002184_abnormal_innervation0.78470627
130MP0002161_abnormal_fertility/fecundity0.77430603
131MP0001533_abnormal_skeleton_physiology0.76937144
132MP0001243_abnormal_dermal_layer0.76089506
133MP0000689_abnormal_spleen_morphology0.75968532
134MP0000343_altered_response_to0.75312721
135MP0009697_abnormal_copulation0.74633799
136MP0003191_abnormal_cellular_cholesterol0.74492947
137MP0004742_abnormal_vestibular_system0.74421052
138MP0006054_spinal_hemorrhage0.74316548
139MP0004272_abnormal_basement_membrane0.73751045
140MP0002148_abnormal_hypersensitivity_rea0.72624849
141MP0003890_abnormal_embryonic-extraembry0.72071306
142MP0000566_synostosis0.71851101
143MP0005390_skeleton_phenotype0.71605725
144MP0001929_abnormal_gametogenesis0.71504379
145MP0002452_abnormal_antigen_presenting0.71469073
146MP0002398_abnormal_bone_marrow0.71233009
147MP0003656_abnormal_erythrocyte_physiolo0.70799248
148MP0001188_hyperpigmentation0.70633114
149MP0009672_abnormal_birth_weight0.70006028
150MP0002081_perinatal_lethality0.69915806
151MP0005621_abnormal_cell_physiology0.69804737
152MP0003828_pulmonary_edema0.69598233
153MP0001299_abnormal_eye_distance/0.68754357
154MP0000653_abnormal_sex_gland0.68303004
155MP0009931_abnormal_skin_appearance0.68299643
156MP0000026_abnormal_inner_ear0.68162916
157MP0005395_other_phenotype0.67922504
158MP0000685_abnormal_immune_system0.67905204
159MP0005464_abnormal_platelet_physiology0.67850341
160MP0005508_abnormal_skeleton_morphology0.67144599
161MP0003279_aneurysm0.67016617
162MP0002429_abnormal_blood_cell0.65400042
163MP0000377_abnormal_hair_follicle0.65168126
164MP0000627_abnormal_mammary_gland0.64600876
165MP0001800_abnormal_humoral_immune0.64418522
166MP0003091_abnormal_cell_migration0.64079510

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.22813991
2Lipid accumulation in hepatocytes (HP:0006561)3.57775811
3Renal Fanconi syndrome (HP:0001994)3.55663388
4Macrocytic anemia (HP:0001972)3.44811294
5Cortical dysplasia (HP:0002539)3.37681099
6Trismus (HP:0000211)3.00737325
7Congenital, generalized hypertrichosis (HP:0004540)3.00324289
8Selective tooth agenesis (HP:0001592)2.91571608
9Degeneration of anterior horn cells (HP:0002398)2.83620986
10Abnormality of the anterior horn cell (HP:0006802)2.83620986
11Pallor (HP:0000980)2.81431287
12Limb dystonia (HP:0002451)2.80787489
13Absent septum pellucidum (HP:0001331)2.78713757
14Carpal bone hypoplasia (HP:0001498)2.71245895
15Breast hypoplasia (HP:0003187)2.67280908
1611 pairs of ribs (HP:0000878)2.66624542
17Reticulocytopenia (HP:0001896)2.65862018
18Concave nail (HP:0001598)2.61721772
19Multiple enchondromatosis (HP:0005701)2.60049231
20Mitochondrial inheritance (HP:0001427)2.58737189
21Rough bone trabeculation (HP:0100670)2.56947795
22Acute necrotizing encephalopathy (HP:0006965)2.52842566
23Bilateral microphthalmos (HP:0007633)2.52546909
24Birth length less than 3rd percentile (HP:0003561)2.51835645
25Supernumerary spleens (HP:0009799)2.51569740
26Exertional dyspnea (HP:0002875)2.49700033
27Respiratory difficulties (HP:0002880)2.48901695
28Oral leukoplakia (HP:0002745)2.48119183
29Generalized aminoaciduria (HP:0002909)2.46835711
30Metaphyseal cupping (HP:0003021)2.41148234
31Shoulder girdle muscle weakness (HP:0003547)2.40288187
32Nasolacrimal duct obstruction (HP:0000579)2.38607791
33Abnormality of the septum pellucidum (HP:0007375)2.38155887
34Protrusio acetabuli (HP:0003179)2.36941912
35Chromsome breakage (HP:0040012)2.32613709
36Septo-optic dysplasia (HP:0100842)2.31963146
37Abnormal number of incisors (HP:0011064)2.30630154
38Abnormality of the distal phalanges of the toes (HP:0010182)2.30222030
39Short nail (HP:0001799)2.30021721
40Increased CSF lactate (HP:0002490)2.29752865
41Abnormal mitochondria in muscle tissue (HP:0008316)2.28523880
42Hypoplastic pelvis (HP:0008839)2.28314054
43Hepatic necrosis (HP:0002605)2.23888880
44Amniotic constriction ring (HP:0009775)2.22338005
45Abnormality of placental membranes (HP:0011409)2.22338005
46Increased intramyocellular lipid droplets (HP:0012240)2.21205924
47Agnosia (HP:0010524)2.20747081
48Cervical subluxation (HP:0003308)2.18655178
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16974246
50Missing ribs (HP:0000921)2.15369426
51Flat acetabular roof (HP:0003180)2.14928616
52Increased serum pyruvate (HP:0003542)2.13873583
53Abnormality of pyrimidine metabolism (HP:0004353)2.13762656
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11706415
55Irregular epiphyses (HP:0010582)2.10874931
56Acute encephalopathy (HP:0006846)2.10370798
57Hypothermia (HP:0002045)2.09065066
58Abnormality of the lacrimal duct (HP:0011481)2.08042788
59Colon cancer (HP:0003003)2.07051736
60Congenital ichthyosiform erythroderma (HP:0007431)2.06564616
61Hepatocellular necrosis (HP:0001404)2.06366432
62Aplasia of the musculature (HP:0100854)2.04680536
63Abnormality of the phalanges of the hallux (HP:0010057)2.03597852
64Deviation of the thumb (HP:0009603)2.01359722
65Down-sloping shoulders (HP:0200021)1.99928769
66Stillbirth (HP:0003826)1.98747026
67Short tibia (HP:0005736)1.98636144
68Pustule (HP:0200039)1.98144898
69Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96147166
70Vertebral hypoplasia (HP:0008417)1.96147166
71Distal lower limb muscle weakness (HP:0009053)1.95608467
72Abnormality of glycolysis (HP:0004366)1.95436472
73Abnormal trabecular bone morphology (HP:0100671)1.93759734
74Hypoplasia of the pons (HP:0012110)1.93720736
75Glossoptosis (HP:0000162)1.93211701
76Neonatal short-limb short stature (HP:0008921)1.93088459
77Thrombocytosis (HP:0001894)1.90978907
78Abnormality of the nasolacrimal system (HP:0000614)1.90829869
79Osteolytic defects of the phalanges of the hand (HP:0009771)1.90785869
80Osteolytic defects of the hand bones (HP:0009699)1.90785869
81Pelvic girdle muscle weakness (HP:0003749)1.90450808
82Patellar aplasia (HP:0006443)1.89341873
83Absent radius (HP:0003974)1.88519666
84Abnormality of the pons (HP:0007361)1.88407438
85Sparse eyelashes (HP:0000653)1.87861169
86Abnormality of the proximal phalanges of the hand (HP:0009834)1.86262476
87Abnormality of cells of the erythroid lineage (HP:0012130)1.85818472
88Esophageal atresia (HP:0002032)1.85617341
89Premature rupture of membranes (HP:0001788)1.85184703
90Premature ovarian failure (HP:0008209)1.83215729
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82797134
92Abnormality of abdominal situs (HP:0011620)1.82774693
93Abdominal situs inversus (HP:0003363)1.82774693
94Progressive macrocephaly (HP:0004481)1.82247487
95Myelodysplasia (HP:0002863)1.81415006
96Aplastic anemia (HP:0001915)1.81398560
97Spinal muscular atrophy (HP:0007269)1.81113862
98Aplasia/Hypoplasia of the patella (HP:0006498)1.80642126
99Abnormality of renal resorption (HP:0011038)1.80450487
100Abnormality of reticulocytes (HP:0004312)1.79976977
101Eczematoid dermatitis (HP:0000976)1.78176999
102Maternal diabetes (HP:0009800)1.77968737
103Abnormality of the calcaneus (HP:0008364)1.77054678
104Duodenal stenosis (HP:0100867)1.75733248
105Small intestinal stenosis (HP:0012848)1.75733248
106Decreased subcutaneous fat (HP:0001002)1.75720810
107Abnormality of the preputium (HP:0100587)1.75503718
108Microretrognathia (HP:0000308)1.75261660
109Cupped ribs (HP:0000887)1.74860305
110Proximal placement of thumb (HP:0009623)1.74400025
111Increased nuchal translucency (HP:0010880)1.74093544
112Vertebral compression fractures (HP:0002953)1.73800272
113Aplasia/hypoplasia of the humerus (HP:0006507)1.73639894
114Myelomeningocele (HP:0002475)1.72796997
115Triphalangeal thumb (HP:0001199)1.72068625
116Impulsivity (HP:0100710)1.72019935
117Aseptic necrosis (HP:0010885)1.71626501
118Breech presentation (HP:0001623)1.70714220
119Abnormality of urine glucose concentration (HP:0011016)1.70305102
120Glycosuria (HP:0003076)1.70305102
121Abnormal foot bone ossification (HP:0010675)1.69768826
122Fused cervical vertebrae (HP:0002949)1.69713267
123Absent thumb (HP:0009777)1.69702446
124Aplasia involving forearm bones (HP:0009822)1.69685024
125Absent forearm bone (HP:0003953)1.69685024
126Abnormal cartilage morphology (HP:0002763)1.68929138
127Midline defect of the nose (HP:0004122)1.67921294
128Abnormality of the musculature of the pelvis (HP:0001469)1.67873296
129Abnormality of the hip-girdle musculature (HP:0001445)1.67873296
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67411958
131Meckel diverticulum (HP:0002245)1.66897834
132Atresia of the external auditory canal (HP:0000413)1.65776825
133Abnormal number of erythroid precursors (HP:0012131)1.65315505
134Abnormality of the acetabulum (HP:0003170)1.64910922
135Esophageal varix (HP:0002040)1.64668551
136Aplasia/Hypoplasia of the scapulae (HP:0006713)1.64363697
137Hypoplastic scapulae (HP:0000882)1.64363697
138Nail dystrophy (HP:0008404)1.63551266
139Ependymoma (HP:0002888)1.63544298
140Abnormal vertebral ossification (HP:0100569)1.63320708
141Right ventricular cardiomyopathy (HP:0011663)1.62864701
142Abnormality of the umbilical cord (HP:0010881)1.62709732
143Abnormal pupillary function (HP:0007686)1.62707361
144Nausea (HP:0002018)1.62412216
145Hypoplastic left heart (HP:0004383)1.62038601
146Partial duplication of thumb phalanx (HP:0009944)1.61461302
147Peritonitis (HP:0002586)1.61231968
148Malignant gastrointestinal tract tumors (HP:0006749)1.60853507
149Gastrointestinal carcinoma (HP:0002672)1.60853507
150Hyperphosphaturia (HP:0003109)1.60391942
151Partial duplication of the phalanx of hand (HP:0009999)1.60169741
152Rhabdomyosarcoma (HP:0002859)1.59627045
153Duplication of thumb phalanx (HP:0009942)1.59461064
154Broad distal phalanx of finger (HP:0009836)1.57919890
155Recurrent abscess formation (HP:0002722)1.57820757
156Ankle contracture (HP:0006466)1.57788475
157Abnormal lung lobation (HP:0002101)1.57499924
158Increased muscle lipid content (HP:0009058)1.56828096
159Tracheoesophageal fistula (HP:0002575)1.56509297
160Limb-girdle muscle atrophy (HP:0003797)1.55664107
161Abnormalities of placenta or umbilical cord (HP:0001194)1.55416800
162Abnormality of the ileum (HP:0001549)1.55329834
163Blepharitis (HP:0000498)1.55100151
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.54935951
165Abnormality of the duodenum (HP:0002246)1.54252420
166Neoplasm of the pancreas (HP:0002894)1.54167419
167Short humerus (HP:0005792)1.53836468
168Sparse lateral eyebrow (HP:0005338)1.53441577
169Aplasia/Hypoplasia of the sacrum (HP:0008517)1.53307997
170Natal tooth (HP:0000695)1.52435000
171Ureteral duplication (HP:0000073)1.52209557
172Biconcave vertebral bodies (HP:0004586)1.51871519
1733-Methylglutaconic aciduria (HP:0003535)1.51757276
174Increased connective tissue (HP:0009025)1.51743127
175Woolly hair (HP:0002224)1.51321699
176Secondary amenorrhea (HP:0000869)1.51108296
177Stenosis of the external auditory canal (HP:0000402)1.50978654
178Aplasia/Hypoplasia of the uvula (HP:0010293)1.50383995

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.90374829
2PNCK3.26586161
3EPHA22.87530872
4WEE12.86878430
5VRK22.63780699
6STK102.53904066
7MAP3K122.21201099
8TTK2.18993253
9EIF2AK12.15579758
10CDK122.13713749
11MARK12.12863041
12NME22.02409841
13RPS6KB21.99714250
14NEK21.98464915
15CDC71.98360172
16MAP3K31.96997396
17TESK11.96289912
18TESK21.94393012
19NEK11.93593220
20PIM21.87130105
21RPS6KA41.81760915
22ERN11.80909074
23BRSK21.66709399
24MAP3K81.60391787
25PLK11.55012815
26NME11.54891712
27AURKB1.51282343
28DYRK21.47443998
29PAK41.45536633
30CDK71.39969433
31TGFBR11.37997913
32EPHB21.32626959
33ERBB41.30776340
34ZAK1.30248240
35MAP3K111.28735069
36MAPK151.23951949
37PLK41.23080645
38MAP2K31.22595997
39AURKA1.20554115
40MST41.17647290
41MAP3K91.15822219
42TRIM281.15583825
43STK41.13550529
44EIF2AK31.13305759
45PKN21.13272482
46LRRK21.07658481
47MAPKAPK31.06823285
48PDK21.06538319
49PIM11.03206737
50BRSK11.02792454
51PLK31.01993784
52MAP3K101.01748336
53CDK40.98368552
54IRAK30.98282008
55CDK60.98023964
56PASK0.97524905
57EEF2K0.97119325
58TNIK0.95211075
59TRIB30.94926406
60STK38L0.94716410
61TSSK60.94057806
62STK160.91574479
63ATR0.91276502
64TAOK20.89352451
65PBK0.87944038
66CHEK20.87351808
67LMTK20.84583847
68TLK10.83898346
69SIK10.82206465
70EIF2AK20.81755633
71NEK90.81737382
72MELK0.80173947
73MKNK10.80056905
74PAK10.79258095
75MAP2K20.77600963
76LIMK10.77164108
77IKBKB0.76456233
78DYRK30.76297981
79CHEK10.75972996
80STK30.75911076
81ERBB30.74104427
82LATS20.73888196
83TTN0.72299326
84ILK0.72085503
85KDR0.71559088
86VRK10.71225756
87SRPK10.70192898
88SCYL20.69537920
89MAPK130.68673727
90ACVR1B0.68402567
91TYK20.66209724
92BLK0.65680695
93CDK80.65111634
94MST1R0.64915344
95MINK10.63696129
96BMX0.63619815
97MAP4K10.63373547
98UHMK10.63058542
99CHUK0.62973137
100MAPKAPK20.62965539
101PTK20.62679271
102FLT30.61283118
103GRK60.60342208
104KSR10.58798738
105TBK10.55422959
106TAOK10.54996493
107CDK150.54684404
108TRPM70.54626062
109PRKCI0.54530345
110ABL20.54394558
111CDK180.54270390
112ALK0.54044355
113TAF10.53556839
114LATS10.52352243
115CDK11A0.52251648
116WNK30.51700893
117CCNB10.51286034
118MET0.50867533
119PTK60.50260364
120STK240.50256161
121CSNK1E0.49564848
122CAMK2B0.49482585
123MOS0.49339968
124PRKG20.48755362
125CSNK2A20.48350606
126CDK30.47821608
127WNK40.47450381
128CDK140.46705743
129CDK10.45489084
130RIPK10.45375857
131CDK20.44495417
132MTOR0.44444822
133ZAP700.42683543
134BTK0.42634237
135CLK10.42460832
136MAP3K140.41757612
137PAK20.40967736
138ICK0.40817803
139MKNK20.40519245
140CSNK2A10.40232398
141BRAF0.37162615
142MAPKAPK50.36742633
143PRKCG0.36431436
144NTRK30.35473528
145CAMK1D0.32772241
146GRK70.32084922
147MAPK40.29156874

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.79877122
2DNA replication_Homo sapiens_hsa030303.55725701
3Parkinsons disease_Homo sapiens_hsa050123.47331758
4Mismatch repair_Homo sapiens_hsa034302.94195463
5Proteasome_Homo sapiens_hsa030502.90494232
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75738784
7Huntingtons disease_Homo sapiens_hsa050162.66962572
8Base excision repair_Homo sapiens_hsa034102.60002936
9Ribosome_Homo sapiens_hsa030102.54813254
10One carbon pool by folate_Homo sapiens_hsa006702.54130071
11RNA transport_Homo sapiens_hsa030132.36911168
12Alzheimers disease_Homo sapiens_hsa050102.33385038
13Cell cycle_Homo sapiens_hsa041102.32003396
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.17186902
15Spliceosome_Homo sapiens_hsa030402.08634231
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04845511
17Cardiac muscle contraction_Homo sapiens_hsa042602.03463325
18Homologous recombination_Homo sapiens_hsa034401.91246493
19Nucleotide excision repair_Homo sapiens_hsa034201.87802099
20Protein export_Homo sapiens_hsa030601.87501229
21p53 signaling pathway_Homo sapiens_hsa041151.85960918
22RNA polymerase_Homo sapiens_hsa030201.85463123
23Pyrimidine metabolism_Homo sapiens_hsa002401.69732192
24Steroid biosynthesis_Homo sapiens_hsa001001.54705409
25Pyruvate metabolism_Homo sapiens_hsa006201.45581405
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43116407
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.41685775
28* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.40393700
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.39298020
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39150369
31Pentose and glucuronate interconversions_Homo sapiens_hsa000401.38313528
32Glutathione metabolism_Homo sapiens_hsa004801.36941454
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36364965
34Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32515335
35Basal cell carcinoma_Homo sapiens_hsa052171.29779533
36Legionellosis_Homo sapiens_hsa051341.28150612
37Fanconi anemia pathway_Homo sapiens_hsa034601.23947732
38RNA degradation_Homo sapiens_hsa030181.19773779
39Non-homologous end-joining_Homo sapiens_hsa034501.19671364
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08099356
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.07675898
42Epstein-Barr virus infection_Homo sapiens_hsa051691.06869603
43Pentose phosphate pathway_Homo sapiens_hsa000301.05849722
44* Apoptosis_Homo sapiens_hsa042101.05648773
45Viral carcinogenesis_Homo sapiens_hsa052031.04522484
46Systemic lupus erythematosus_Homo sapiens_hsa053221.04359219
47Selenocompound metabolism_Homo sapiens_hsa004501.03319727
48Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00149495
49Basal transcription factors_Homo sapiens_hsa030221.00028226
50Antigen processing and presentation_Homo sapiens_hsa046120.99666283
51Folate biosynthesis_Homo sapiens_hsa007900.98431350
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.95856789
53Herpes simplex infection_Homo sapiens_hsa051680.95766808
54Small cell lung cancer_Homo sapiens_hsa052220.93008082
55Leishmaniasis_Homo sapiens_hsa051400.92188597
56Bladder cancer_Homo sapiens_hsa052190.90148043
57Oocyte meiosis_Homo sapiens_hsa041140.88121376
58Biosynthesis of amino acids_Homo sapiens_hsa012300.87638901
59Chemical carcinogenesis_Homo sapiens_hsa052040.87329506
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87076541
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83607529
62Fructose and mannose metabolism_Homo sapiens_hsa000510.83535640
63Shigellosis_Homo sapiens_hsa051310.83145744
64HTLV-I infection_Homo sapiens_hsa051660.82736621
65Sulfur relay system_Homo sapiens_hsa041220.82270320
66Hedgehog signaling pathway_Homo sapiens_hsa043400.82038022
67Galactose metabolism_Homo sapiens_hsa000520.81950162
68MicroRNAs in cancer_Homo sapiens_hsa052060.81836845
69mRNA surveillance pathway_Homo sapiens_hsa030150.81587725
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.79909164
71N-Glycan biosynthesis_Homo sapiens_hsa005100.78440612
72Phenylalanine metabolism_Homo sapiens_hsa003600.78427699
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77510600
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.76636894
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75077189
76Adherens junction_Homo sapiens_hsa045200.72183891
77Nicotine addiction_Homo sapiens_hsa050330.71787056
78TGF-beta signaling pathway_Homo sapiens_hsa043500.69627207
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68998704
80Thyroid cancer_Homo sapiens_hsa052160.68367167
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67749529
82Hippo signaling pathway_Homo sapiens_hsa043900.63361171
83Wnt signaling pathway_Homo sapiens_hsa043100.62926576
84Arachidonic acid metabolism_Homo sapiens_hsa005900.60081067
85Metabolic pathways_Homo sapiens_hsa011000.59986176
86Axon guidance_Homo sapiens_hsa043600.59707936
87Tyrosine metabolism_Homo sapiens_hsa003500.59107743
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.57454181
89Staphylococcus aureus infection_Homo sapiens_hsa051500.57081829
90Glycosaminoglycan degradation_Homo sapiens_hsa005310.55466327
91Purine metabolism_Homo sapiens_hsa002300.54664953
92Influenza A_Homo sapiens_hsa051640.54535030
93Chronic myeloid leukemia_Homo sapiens_hsa052200.54274268
94Other glycan degradation_Homo sapiens_hsa005110.54108250
95Carbon metabolism_Homo sapiens_hsa012000.53822559
96Malaria_Homo sapiens_hsa051440.52790998
97Hepatitis B_Homo sapiens_hsa051610.52206114
98* Gap junction_Homo sapiens_hsa045400.52133766
99Sulfur metabolism_Homo sapiens_hsa009200.51049468
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50886981
101Alcoholism_Homo sapiens_hsa050340.50766727
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50609433
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50498244
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50149855
105Toxoplasmosis_Homo sapiens_hsa051450.49864241
106Retinol metabolism_Homo sapiens_hsa008300.48917768
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48467822
108TNF signaling pathway_Homo sapiens_hsa046680.48261512
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48074938
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46649261
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46035688
112Measles_Homo sapiens_hsa051620.44975992
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44931804
114Vitamin digestion and absorption_Homo sapiens_hsa049770.44734225
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.44524776
116Renin-angiotensin system_Homo sapiens_hsa046140.43302632
117Proteoglycans in cancer_Homo sapiens_hsa052050.42793786
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.42361134
119Starch and sucrose metabolism_Homo sapiens_hsa005000.41954551
120Viral myocarditis_Homo sapiens_hsa054160.41743763
121Vibrio cholerae infection_Homo sapiens_hsa051100.41450629
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41315123
123Pertussis_Homo sapiens_hsa051330.41146175
124ECM-receptor interaction_Homo sapiens_hsa045120.40749485
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40695664
126Vitamin B6 metabolism_Homo sapiens_hsa007500.39586023
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38986152
128HIF-1 signaling pathway_Homo sapiens_hsa040660.38282051
129Cocaine addiction_Homo sapiens_hsa050300.38037132
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37238042
131Hematopoietic cell lineage_Homo sapiens_hsa046400.37046404
132Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36159248
133Fatty acid elongation_Homo sapiens_hsa000620.35132446
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34761380
135Asthma_Homo sapiens_hsa053100.34350779
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34334901
137Taste transduction_Homo sapiens_hsa047420.33894698
138Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33580145
139Collecting duct acid secretion_Homo sapiens_hsa049660.31711952
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31467313
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.31034011
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30788717
143Pathways in cancer_Homo sapiens_hsa052000.29824035
144Tryptophan metabolism_Homo sapiens_hsa003800.28392252
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27093424
146Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26919145
147Arginine and proline metabolism_Homo sapiens_hsa003300.23002728
148Melanogenesis_Homo sapiens_hsa049160.20701348
149Tight junction_Homo sapiens_hsa045300.17171420
150Renal cell carcinoma_Homo sapiens_hsa052110.16530694

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