TUBA4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.09489445
2tricarboxylic acid cycle (GO:0006099)4.61960003
3glutamate secretion (GO:0014047)4.57146935
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.57071707
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.54615220
6synaptic vesicle exocytosis (GO:0016079)4.44622300
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.44087027
8NADH metabolic process (GO:0006734)4.39747526
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.38002790
10synaptic vesicle maturation (GO:0016188)4.35753384
11negative regulation of cell killing (GO:0031342)4.25796220
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.25796220
13neuronal action potential propagation (GO:0019227)4.23882362
14oxaloacetate metabolic process (GO:0006107)4.15002892
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.04371884
16regulation of acyl-CoA biosynthetic process (GO:0050812)4.01081524
17regulation of platelet aggregation (GO:0090330)3.93301050
18G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.92813863
19regulation of cofactor metabolic process (GO:0051193)3.91584089
20regulation of coenzyme metabolic process (GO:0051196)3.91584089
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90839996
22hemidesmosome assembly (GO:0031581)3.89234326
23positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.88352203
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.87200838
25vocalization behavior (GO:0071625)3.81013022
26regulation of synaptic vesicle exocytosis (GO:2000300)3.78462297
27locomotory exploration behavior (GO:0035641)3.76687974
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.76102597
29regulation of synaptic vesicle transport (GO:1902803)3.75429306
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.71368923
31neurotransmitter secretion (GO:0007269)3.69910566
32antigen processing and presentation of endogenous antigen (GO:0019883)3.69223838
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.69204206
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.62918647
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62715549
36establishment of skin barrier (GO:0061436)3.60855107
37positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60084809
38succinate metabolic process (GO:0006105)3.57361441
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55674516
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.51854866
41regulation of synapse structural plasticity (GO:0051823)3.48754011
42regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48041712
43regulation of glutamate receptor signaling pathway (GO:1900449)3.47225140
44sodium ion export (GO:0071436)3.46300321
45killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.41975903
46disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.41975903
47regulation of cell communication by electrical coupling (GO:0010649)3.41851545
48neutrophil activation (GO:0042119)3.39016747
49G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.37374964
50regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.37147575
51regulation of water loss via skin (GO:0033561)3.35477751
52oxidative phosphorylation (GO:0006119)3.34696007
53lipoxygenase pathway (GO:0019372)3.34640899
54activation of protein kinase A activity (GO:0034199)3.32854569
55sarcoplasmic reticulum calcium ion transport (GO:0070296)3.31900459
56cardiac muscle contraction (GO:0060048)3.31307223
57signal complex assembly (GO:0007172)3.29190713
58regulation of B cell receptor signaling pathway (GO:0050855)3.29171070
59regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.23896825
60detection of bacterium (GO:0016045)3.23759557
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.23229949
62adenosine receptor signaling pathway (GO:0001973)3.22173915
63G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21089692
642-oxoglutarate metabolic process (GO:0006103)3.20119687
65cellular potassium ion homeostasis (GO:0030007)3.19245595
66energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18728807
67ATP synthesis coupled proton transport (GO:0015986)3.18728807
68regulation of long-term neuronal synaptic plasticity (GO:0048169)3.17841416
69regulation of oxidative phosphorylation (GO:0002082)3.17738273
70negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.14744548
71regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.11589760
72leukocyte migration involved in inflammatory response (GO:0002523)3.11564885
73leukocyte degranulation (GO:0043299)3.10607203
74sarcomere organization (GO:0045214)3.10109246
75granulocyte activation (GO:0036230)3.09052956
76respiratory electron transport chain (GO:0022904)3.08672289
77cell communication by electrical coupling (GO:0010644)3.08158967
78positive regulation of gamma-delta T cell activation (GO:0046645)3.07947189
79regulation of sodium ion transmembrane transporter activity (GO:2000649)3.07872104
80positive regulation of neurotransmitter secretion (GO:0001956)3.07823257
81regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07229606
82regulation of calcium ion transmembrane transport (GO:1903169)3.07229606
83negative regulation of T cell mediated immunity (GO:0002710)3.06860188
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.06145245
85platelet aggregation (GO:0070527)3.05745471
86neurotransmitter-gated ion channel clustering (GO:0072578)3.04572596
87gluconeogenesis (GO:0006094)3.03422285
88detection of other organism (GO:0098543)3.02701251
89negative regulation of homotypic cell-cell adhesion (GO:0034111)3.01747782
90electron transport chain (GO:0022900)3.01549910
91regulation of neuronal synaptic plasticity (GO:0048168)3.01516361
92mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99844767
93cellular response to interleukin-15 (GO:0071350)2.98272409
94positive regulation of interleukin-4 production (GO:0032753)2.97780477
95cell communication involved in cardiac conduction (GO:0086065)2.97758523
96positive regulation of mast cell activation (GO:0033005)2.97116086
97oxygen transport (GO:0015671)2.96477412
98regulation of sodium ion transmembrane transport (GO:1902305)2.95587666
99aspartate family amino acid catabolic process (GO:0009068)2.95329053
100positive regulation of neurotransmitter transport (GO:0051590)2.94399700
101plasma membrane repair (GO:0001778)2.94388327
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.94340978
103striated muscle contraction (GO:0006941)2.94011746
104ionotropic glutamate receptor signaling pathway (GO:0035235)2.93953168
105neuromuscular process controlling posture (GO:0050884)2.90924327
106myeloid cell activation involved in immune response (GO:0002275)2.90051678
107desmosome organization (GO:0002934)2.89278644
108regulation of sulfur metabolic process (GO:0042762)2.88821606
109response to interleukin-15 (GO:0070672)2.88595807
110regulation of neurotransmitter levels (GO:0001505)2.88576315
111thrombin receptor signaling pathway (GO:0070493)2.87977790
112positive regulation of macrophage differentiation (GO:0045651)2.87849494
113regulation of cellular respiration (GO:0043457)2.86840667
114porphyrin-containing compound biosynthetic process (GO:0006779)2.86632453
115actin-myosin filament sliding (GO:0033275)2.84634016
116muscle filament sliding (GO:0030049)2.84634016
117protein localization to synapse (GO:0035418)2.84237938
118regulation of relaxation of muscle (GO:1901077)2.84147555
119hexose biosynthetic process (GO:0019319)2.83400974
120neurotransmitter transport (GO:0006836)2.83165413
121dicarboxylic acid biosynthetic process (GO:0043650)2.81958167
122positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80554301
123positive regulation of synapse maturation (GO:0090129)2.79279586
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.78793168
125regulation of homotypic cell-cell adhesion (GO:0034110)2.78573085
126lysine metabolic process (GO:0006553)2.78521872
127lysine catabolic process (GO:0006554)2.78521872
128ATP hydrolysis coupled proton transport (GO:0015991)2.77730744
129energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.77730744
130megakaryocyte development (GO:0035855)2.77678849
131glycogen catabolic process (GO:0005980)2.77227527
132negative regulation of potassium ion transmembrane transport (GO:1901380)2.76370551
133neuron-neuron synaptic transmission (GO:0007270)2.75824187
134potassium ion import (GO:0010107)2.75420110
135exploration behavior (GO:0035640)2.73744599
136membrane depolarization during action potential (GO:0086010)2.73359064
137mast cell activation (GO:0045576)2.73127124
138positive regulation of membrane potential (GO:0045838)2.72699190
139regulation of platelet activation (GO:0010543)2.72267288
140regulation of ion transmembrane transporter activity (GO:0032412)2.72204360
141regulation of regulatory T cell differentiation (GO:0045589)2.72090110
142long-term memory (GO:0007616)2.71728447
143negative regulation of lymphocyte mediated immunity (GO:0002707)2.70184572
144leukocyte aggregation (GO:0070486)2.68653268
145regulation of hypersensitivity (GO:0002883)2.64452501
146regulation of T cell mediated cytotoxicity (GO:0001914)2.63740584
147negative T cell selection (GO:0043383)2.63057788
148purinergic nucleotide receptor signaling pathway (GO:0035590)2.62585365
149regulated secretory pathway (GO:0045055)2.61998165
150B cell receptor signaling pathway (GO:0050853)2.61688545
151keratinization (GO:0031424)2.60855967
152negative thymic T cell selection (GO:0045060)2.59751613
153protein neddylation (GO:0045116)2.59717869
154purinergic receptor signaling pathway (GO:0035587)2.58183224
155citrulline biosynthetic process (GO:0019240)2.58130591
156positive regulation of granulocyte differentiation (GO:0030854)2.57677317
157antigen processing and presentation via MHC class Ib (GO:0002475)2.57434914
158positive regulation of T cell mediated cytotoxicity (GO:0001916)2.57031881
159tolerance induction (GO:0002507)2.56503661
160regulation of mast cell degranulation (GO:0043304)2.56312298
161negative regulation of leukocyte mediated immunity (GO:0002704)2.54089806
162angiogenesis involved in wound healing (GO:0060055)2.53230966
163positive regulation of humoral immune response (GO:0002922)2.52268102
164immunoglobulin mediated immune response (GO:0016064)2.51266173
165positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.49438586
166B cell mediated immunity (GO:0019724)2.49011373
167macrophage activation involved in immune response (GO:0002281)2.48717497
168regulation of alpha-beta T cell proliferation (GO:0046640)2.46262254
169negative regulation of thymocyte apoptotic process (GO:0070244)2.44161142
170homotypic cell-cell adhesion (GO:0034109)2.43859475
171membrane tubulation (GO:0097320)2.43163169
172regulation of gamma-delta T cell activation (GO:0046643)2.40838493
173germinal center formation (GO:0002467)2.39757111
174positive regulation of protein dephosphorylation (GO:0035307)2.37324871
175skeletal muscle tissue regeneration (GO:0043403)2.36025743
176negative regulation of T-helper cell differentiation (GO:0045623)2.35014975
177negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35014975
178regulation of natural killer cell mediated immunity (GO:0002715)2.34484273
179regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.34484273
180positive regulation of alpha-beta T cell proliferation (GO:0046641)2.34063913
181regulation of T-helper 2 cell differentiation (GO:0045628)2.33127430
182negative regulation of erythrocyte differentiation (GO:0045647)2.31646977
183cell-substrate junction assembly (GO:0007044)2.30833921
184cytidine metabolic process (GO:0046087)2.30437393
185cytidine catabolic process (GO:0006216)2.30437393
186cytidine deamination (GO:0009972)2.30437393
187negative regulation of interleukin-17 production (GO:0032700)2.30040024
188regulation of mast cell activation involved in immune response (GO:0033006)2.29839967
189actin filament polymerization (GO:0030041)2.28960718
190regulation of T cell mediated immunity (GO:0002709)2.28660531
191regulation of leukocyte degranulation (GO:0043300)2.28460537
192regulation of gamma-delta T cell differentiation (GO:0045586)2.28412502
193positive regulation of B cell mediated immunity (GO:0002714)2.28080980
194positive regulation of immunoglobulin mediated immune response (GO:0002891)2.28080980
195negative regulation of T cell apoptotic process (GO:0070233)2.27325545
196modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.25050369

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41505340
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.67823494
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.56590075
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.81517713
5GATA1_22025678_ChIP-Seq_K562_Human3.76018132
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.44174850
7RARB_27405468_Chip-Seq_BRAIN_Mouse3.35586087
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.18295471
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.89382222
10* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.84189927
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82547256
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.58977284
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.56375013
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.50164207
15REST_21632747_ChIP-Seq_MESCs_Mouse2.40512732
16ZNF263_19887448_ChIP-Seq_K562_Human2.35176736
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30504722
18DNAJC2_21179169_ChIP-ChIP_NT2_Human2.28505323
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.18845823
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14349900
21GATA1_19941827_ChIP-Seq_MEL_Mouse2.13089736
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06669754
23RUNX1_22412390_ChIP-Seq_EML_Mouse2.05548907
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03148267
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.01537629
26* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99071584
27MAF_26560356_Chip-Seq_TH1_Human1.97250913
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97170796
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.90066221
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.89654077
31LXR_22292898_ChIP-Seq_THP-1_Human1.89102636
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88989029
33DROSHA_22980978_ChIP-Seq_HELA_Human1.87540784
34* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82665782
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82541396
36RUNX_20019798_ChIP-Seq_JUKART_Human1.79339387
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.77565790
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74082172
39UTX_26944678_Chip-Seq_JUKART_Human1.73462806
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73132518
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.70750437
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66289610
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.66231200
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66222495
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65896316
46BCL6_27268052_Chip-Seq_Bcells_Human1.65340537
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63908267
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62411953
49SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61666344
50VDR_21846776_ChIP-Seq_THP-1_Human1.61055164
51MYB_26560356_Chip-Seq_TH2_Human1.60332916
52* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.59940348
53GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59261192
54* IRF8_27001747_Chip-Seq_BMDM_Mouse1.58693246
55* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.57812440
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57630726
57EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.56870107
58P68_20966046_ChIP-Seq_HELA_Human1.56613145
59VDR_24763502_ChIP-Seq_THP-1_Human1.54834804
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.50940356
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.46430131
62GATA1_19941826_ChIP-Seq_K562_Human1.46185590
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.42958965
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.42922923
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.41716638
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.41051405
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40045318
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39795842
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39632810
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37733081
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37312439
72TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.36928355
73MYB_26560356_Chip-Seq_TH1_Human1.36488877
74SMC4_20622854_ChIP-Seq_HELA_Human1.36414496
75CTCF_27219007_Chip-Seq_Bcells_Human1.34861337
76SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33119600
77MAF_26560356_Chip-Seq_TH2_Human1.32909553
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.32548298
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32228987
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.31929523
81BCOR_27268052_Chip-Seq_Bcells_Human1.31752541
82SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31639602
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30477720
84SPI1_23547873_ChIP-Seq_NB4_Human1.29870759
85RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29745435
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.28557737
87MTF2_20144788_ChIP-Seq_MESCs_Mouse1.26187010
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24590553
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24475061
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.23386898
91YY1_22570637_ChIP-Seq_MALME-3M_Human1.22422715
92MYC_22102868_ChIP-Seq_BL_Human1.21911813
93CTCF_21964334_ChIP-Seq_BJAB-B_Human1.21646381
94KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21098652
95GATA3_27048872_Chip-Seq_THYMUS_Human1.20996184
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19761632
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19608871
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18852101
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17848520
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17708590
101TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16858348
102SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15621824
103SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15621824
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15211883
105SCL_19346495_ChIP-Seq_HPC-7_Human1.15069286
106ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14836389
107* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.13697241
108ESR2_21235772_ChIP-Seq_MCF-7_Human1.13666637
109FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13286712
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12907469
111* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12378915
112RACK7_27058665_Chip-Seq_MCF-7_Human1.11172283
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10555472
114KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10451623
115SA1_27219007_Chip-Seq_Bcells_Human1.10393881
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10375846
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09354968
118SPI1_20517297_ChIP-Seq_HL60_Human1.08683022
119* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08585431
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08239191
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08119526
122TCF7_22412390_ChIP-Seq_EML_Mouse1.06494498
123JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06288794
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05292495
125GATA2_19941826_ChIP-Seq_K562_Human1.04382434
126NCOR1_26117541_ChIP-Seq_K562_Human1.03804295
127GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03511221
128* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03141579
129CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03068067
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.02827006
131KDM2B_26808549_Chip-Seq_DND41_Human1.02764802
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02565228
133CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01524868
134TAF2_19829295_ChIP-Seq_ESCs_Human1.01422737
135TET1_21451524_ChIP-Seq_MESCs_Mouse1.00972658
136E2F1_20622854_ChIP-Seq_HELA_Human1.00746376
137CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00081147
138BP1_19119308_ChIP-ChIP_Hs578T_Human0.99646840
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99625981
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99269728
141PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99125140
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98813179
143YY1_21170310_ChIP-Seq_MESCs_Mouse0.97680816
144SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97529478
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97009257
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96899104
147PHF8_20622854_ChIP-Seq_HELA_Human0.96516538
148* RXR_22158963_ChIP-Seq_LIVER_Mouse0.95258266
149NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95049808
150SPI1_23127762_ChIP-Seq_K562_Human0.94740950
151CTCF_21964334_Chip-Seq_Bcells_Human0.94626925
152KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93772255
153JARID2_20075857_ChIP-Seq_MESCs_Mouse0.93349565
154* TP63_22573176_ChIP-Seq_HFKS_Human0.92570830
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91490258
156OCT4_19829295_ChIP-Seq_ESCs_Human0.90885289
157PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90739285
158* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90501548
159CIITA_25753668_ChIP-Seq_RAJI_Human0.90487720
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90217456
161FOXH1_21741376_ChIP-Seq_ESCs_Human0.89965363
162NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88871180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.02927638
2MP0005464_abnormal_platelet_physiology4.65545319
3MP0003646_muscle_fatigue4.11087639
4MP0002837_dystrophic_cardiac_calcinosis4.06798742
5MP0000751_myopathy3.44802655
6MP0003880_abnormal_central_pattern3.34609277
7MP0003635_abnormal_synaptic_transmissio3.01286843
8MP0002822_catalepsy2.98548455
9MP0000579_abnormal_nail_morphology2.93686602
10MP0003436_decreased_susceptibility_to2.70333035
11MP0005671_abnormal_response_to2.63342861
12MP0004215_abnormal_myocardial_fiber2.61216659
13MP0000749_muscle_degeneration2.54218498
14MP0000685_abnormal_immune_system2.53695584
15MP0009745_abnormal_behavioral_response2.53113316
16MP0001835_abnormal_antigen_presentation2.41062060
17MP0004270_analgesia2.39745853
18MP0009046_muscle_twitch2.38555418
19MP0002064_seizures2.36629471
20MP0003724_increased_susceptibility_to2.36263846
21MP0004084_abnormal_cardiac_muscle2.34955543
22MP0004036_abnormal_muscle_relaxation2.34761498
23MP0003763_abnormal_thymus_physiology2.32773889
24MP0004947_skin_inflammation2.31624237
25MP0005000_abnormal_immune_tolerance2.29565320
26MP0006036_abnormal_mitochondrial_physio2.28778042
27MP0003656_abnormal_erythrocyte_physiolo2.28066817
28MP0002063_abnormal_learning/memory/cond2.25909156
29MP0001968_abnormal_touch/_nociception2.24805862
30MP0004145_abnormal_muscle_electrophysio2.13633230
31MP0004381_abnormal_hair_follicle2.05461199
32MP0008260_abnormal_autophagy1.99906175
33MP0005387_immune_system_phenotype1.96062123
34MP0001790_abnormal_immune_system1.96062123
35MP0003566_abnormal_cell_adhesion1.94244449
36MP0003303_peritoneal_inflammation1.92322484
37MP0002736_abnormal_nociception_after1.91283600
38MP0001800_abnormal_humoral_immune1.90827850
39MP0000465_gastrointestinal_hemorrhage1.90210817
40MP0000747_muscle_weakness1.86900990
41MP0008004_abnormal_stomach_pH1.84965851
42MP0002272_abnormal_nervous_system1.83689305
43MP0002572_abnormal_emotion/affect_behav1.83062376
44MP0004130_abnormal_muscle_cell1.82511996
45MP0008569_lethality_at_weaning1.79391456
46MP0002723_abnormal_immune_serum1.78983758
47MP0003300_gastrointestinal_ulcer1.78728293
48MP0004147_increased_porphyrin_level1.76926212
49MP0005330_cardiomyopathy1.74355288
50MP0009333_abnormal_splenocyte_physiolog1.73752937
51MP0002148_abnormal_hypersensitivity_rea1.72810690
52MP0002420_abnormal_adaptive_immunity1.71448669
53MP0002269_muscular_atrophy1.70672947
54MP0003453_abnormal_keratinocyte_physiol1.70558350
55MP0006035_abnormal_mitochondrial_morpho1.68784938
56MP0001819_abnormal_immune_cell1.68656307
57MP0003329_amyloid_beta_deposits1.67869669
58MP0005451_abnormal_body_composition1.67451146
59MP0002909_abnormal_adrenal_gland1.67229448
60MP0004484_altered_response_of1.66932255
61MP0005025_abnormal_response_to1.64354046
62MP0002398_abnormal_bone_marrow1.64331822
63MP0002452_abnormal_antigen_presenting1.63665783
64MP0001501_abnormal_sleep_pattern1.63095551
65MP0002735_abnormal_chemical_nociception1.60873754
66MP0004087_abnormal_muscle_fiber1.58341100
67MP0001440_abnormal_grooming_behavior1.58281067
68MP0003045_fibrosis1.57709927
69MP0010155_abnormal_intestine_physiology1.56350257
70MP0009785_altered_susceptibility_to1.53019532
71MP0002419_abnormal_innate_immunity1.52668043
72MP0002106_abnormal_muscle_physiology1.52282688
73MP0001851_eye_inflammation1.50789496
74MP0002734_abnormal_mechanical_nocicepti1.50423206
75MP0005501_abnormal_skin_physiology1.48889806
76MP0005620_abnormal_muscle_contractility1.48638177
77MP0003879_abnormal_hair_cell1.46420321
78MP0003191_abnormal_cellular_cholesterol1.40454903
79MP0008872_abnormal_physiological_respon1.39128613
80MP0003866_abnormal_defecation1.38525256
81MP0008874_decreased_physiological_sensi1.38237755
82MP0001970_abnormal_pain_threshold1.35882987
83MP0002972_abnormal_cardiac_muscle1.34406392
84MP0004924_abnormal_behavior1.32578741
85MP0005386_behavior/neurological_phenoty1.32578741
86MP0000716_abnormal_immune_system1.31348682
87MP0005166_decreased_susceptibility_to1.28911676
88MP0000759_abnormal_skeletal_muscle1.28477642
89MP0002067_abnormal_sensory_capabilities1.28161673
90MP0001529_abnormal_vocalization1.28012402
91MP0002733_abnormal_thermal_nociception1.27618209
92MP0001486_abnormal_startle_reflex1.26714871
93MP0001216_abnormal_epidermal_layer1.24656833
94MP0004085_abnormal_heartbeat1.23386020
95MP0003137_abnormal_impulse_conducting1.22125481
96MP0003633_abnormal_nervous_system1.21678730
97MP0005535_abnormal_body_temperature1.20279233
98MP0001845_abnormal_inflammatory_respons1.18635267
99MP0004811_abnormal_neuron_physiology1.17435237
100MP0002722_abnormal_immune_system1.17272659
101MP0001533_abnormal_skeleton_physiology1.15824986
102MP0002429_abnormal_blood_cell1.14454938
103MP0003075_altered_response_to1.14149867
104MP0005369_muscle_phenotype1.13957047
105MP0003806_abnormal_nucleotide_metabolis1.13542961
106MP0000689_abnormal_spleen_morphology1.12954805
107MP0000703_abnormal_thymus_morphology1.12552768
108MP0004233_abnormal_muscle_weight1.10792908
109MP0000750_abnormal_muscle_regeneration1.10361239
110MP0004142_abnormal_muscle_tone1.08110621
111MP0005266_abnormal_metabolism1.07134232
112MP0005083_abnormal_biliary_tract1.06114931
113MP0005423_abnormal_somatic_nervous1.05904039
114MP0004510_myositis1.04863795
115MP0008775_abnormal_heart_ventricle1.04118246
116MP0000858_altered_metastatic_potential1.03977798
117MP0005085_abnormal_gallbladder_physiolo1.03488994
118MP0009780_abnormal_chondrocyte_physiolo1.03161585
119MP0000343_altered_response_to1.02341511
120MP0004043_abnormal_pH_regulation1.01107639
121MP0008961_abnormal_basal_metabolism1.00690288
122MP0003221_abnormal_cardiomyocyte_apopto1.00659936
123MP0003638_abnormal_response/metabolism_1.00505714
124MP0002332_abnormal_exercise_endurance1.00141239
125MP0001544_abnormal_cardiovascular_syste0.99167160
126MP0005385_cardiovascular_system_phenoty0.99167160
127MP0002166_altered_tumor_susceptibility0.98852052
128MP0001905_abnormal_dopamine_level0.97391659
129MP0005584_abnormal_enzyme/coenzyme_acti0.96761751
130MP0002066_abnormal_motor_capabilities/c0.93778817
131MP0005310_abnormal_salivary_gland0.93270262
132MP0004858_abnormal_nervous_system0.93109939
133MP0005646_abnormal_pituitary_gland0.92806612
134MP0001765_abnormal_ion_homeostasis0.92167144
135MP0005409_darkened_coat_color0.91102883
136MP0010771_integument_phenotype0.90148685
137MP0010234_abnormal_vibrissa_follicle0.87281047
138MP0002405_respiratory_system_inflammati0.86441476
139MP0003631_nervous_system_phenotype0.85310794
140MP0003828_pulmonary_edema0.85105729
141MP0008875_abnormal_xenobiotic_pharmacok0.85033172
142MP0002138_abnormal_hepatobiliary_system0.83682919
143MP0000013_abnormal_adipose_tissue0.82418539
144MP0010678_abnormal_skin_adnexa0.81581961
145MP0005023_abnormal_wound_healing0.80156443
146MP0005165_increased_susceptibility_to0.78276851
147MP0010329_abnormal_lipoprotein_level0.77372017
148MP0002006_tumorigenesis0.77257690
149MP0000467_abnormal_esophagus_morphology0.76491015
150MP0002557_abnormal_social/conspecific_i0.73721283
151MP0010630_abnormal_cardiac_muscle0.73514411
152MP0009931_abnormal_skin_appearance0.73029853
153MP0009763_increased_sensitivity_to0.72669254
154MP0000604_amyloidosis0.72255368
155MP0005058_abnormal_lysosome_morphology0.71431955
156MP0002796_impaired_skin_barrier0.70495999
157MP0001984_abnormal_olfaction0.70475590
158MP0006138_congestive_heart_failure0.69576052
159MP0002693_abnormal_pancreas_physiology0.68792049
160MP0006276_abnormal_autonomic_nervous0.68719570
161MP0008469_abnormal_protein_level0.68620894
162MP0005360_urolithiasis0.68329945
163MP0003183_abnormal_peptide_metabolism0.67137117
164MP0005319_abnormal_enzyme/_coenzyme0.66630107
165MP0005410_abnormal_fertilization0.66190297
166MP0005636_abnormal_mineral_homeostasis0.65804036
167MP0002078_abnormal_glucose_homeostasis0.65707676

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.62479952
2Petechiae (HP:0000967)5.21119091
3Focal motor seizures (HP:0011153)4.99753255
4Exercise-induced myalgia (HP:0003738)4.76724467
5Menorrhagia (HP:0000132)4.74700809
6Abnormal platelet volume (HP:0011876)4.64346564
7Increased mean platelet volume (HP:0011877)4.54436917
8Purpura (HP:0000979)4.29089585
9Exercise-induced muscle cramps (HP:0003710)4.25268819
10Visual hallucinations (HP:0002367)4.20703278
11Sudden death (HP:0001699)4.17914421
12Myokymia (HP:0002411)4.16489868
13Epistaxis (HP:0000421)3.98409861
14Onycholysis (HP:0001806)3.87892619
15Calf muscle hypertrophy (HP:0008981)3.72169063
16Abnormality of nail color (HP:0100643)3.68341185
17Muscle hypertrophy of the lower extremities (HP:0008968)3.67291931
18Focal seizures (HP:0007359)3.65002047
19Myoglobinuria (HP:0002913)3.63350909
20Plantar hyperkeratosis (HP:0007556)3.52456123
21Gingival bleeding (HP:0000225)3.48380514
22Milia (HP:0001056)3.47583743
23Thick nail (HP:0001805)3.37708445
24Epileptic encephalopathy (HP:0200134)3.32148656
25Dysmetric saccades (HP:0000641)3.27361937
26Bundle branch block (HP:0011710)3.27306237
27Poor eye contact (HP:0000817)3.25273402
28Eczematoid dermatitis (HP:0000976)3.24918184
29Ventricular fibrillation (HP:0001663)3.15925236
30Increased IgE level (HP:0003212)3.07436569
31Hyperlipoproteinemia (HP:0010980)3.06965649
32Generalized tonic-clonic seizures (HP:0002069)3.05182819
33Ventricular tachycardia (HP:0004756)3.03155178
34Hepatocellular necrosis (HP:0001404)3.02917205
35Myotonia (HP:0002486)2.97175647
36Stomatitis (HP:0010280)2.96759112
37Febrile seizures (HP:0002373)2.92215455
38Abnormal mitochondria in muscle tissue (HP:0008316)2.92027183
39Hepatic necrosis (HP:0002605)2.91587094
40Impaired social interactions (HP:0000735)2.90439503
41Abnormal social behavior (HP:0012433)2.90439503
42Palmoplantar hyperkeratosis (HP:0000972)2.88717010
43Abnormality of macrophages (HP:0004311)2.83399154
44Atonic seizures (HP:0010819)2.82648305
45Cholelithiasis (HP:0001081)2.76826775
46Acute necrotizing encephalopathy (HP:0006965)2.74037090
47Impaired platelet aggregation (HP:0003540)2.71880903
48Abnormal platelet function (HP:0011869)2.71880903
49EMG: myopathic abnormalities (HP:0003458)2.70693948
50Abnormality of the calf musculature (HP:0001430)2.70175188
51Fragile nails (HP:0001808)2.70013210
52Absence seizures (HP:0002121)2.69802058
53Hyporeflexia of lower limbs (HP:0002600)2.65900463
54Rhabdomyolysis (HP:0003201)2.64671846
55Cholecystitis (HP:0001082)2.64483813
56Abnormal gallbladder physiology (HP:0012438)2.64483813
57Abnormal blistering of the skin (HP:0008066)2.64466982
58Muscle fiber inclusion bodies (HP:0100299)2.63346417
59Mitochondrial inheritance (HP:0001427)2.61977386
60Muscle stiffness (HP:0003552)2.61345780
61Ridged nail (HP:0001807)2.60242223
62Nail dystrophy (HP:0008404)2.59979690
63Abnormality of binocular vision (HP:0011514)2.58855158
64Diplopia (HP:0000651)2.58855158
65Recurrent bacterial skin infections (HP:0005406)2.58057578
66Depression (HP:0000716)2.57774827
67Resting tremor (HP:0002322)2.57515658
68Palmar hyperkeratosis (HP:0010765)2.56941748
69Paralysis (HP:0003470)2.52977588
70Increased CSF lactate (HP:0002490)2.51366755
71Dialeptic seizures (HP:0011146)2.50172343
72Acute encephalopathy (HP:0006846)2.49255524
73Impaired vibration sensation in the lower limbs (HP:0002166)2.48499180
74Palpitations (HP:0001962)2.47813297
75Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46835554
76Status epilepticus (HP:0002133)2.45540408
77Alopecia of scalp (HP:0002293)2.45534885
78Atrial fibrillation (HP:0005110)2.45426472
79Testicular atrophy (HP:0000029)2.44374716
80Syncope (HP:0001279)2.43610962
81Abnormal gallbladder morphology (HP:0012437)2.42710022
82Supraventricular tachycardia (HP:0004755)2.41979871
83Ragged-red muscle fibers (HP:0003200)2.41853644
84Distal lower limb muscle weakness (HP:0009053)2.41344689
85Increased muscle lipid content (HP:0009058)2.40356629
86Heart block (HP:0012722)2.40189065
87Primary atrial arrhythmia (HP:0001692)2.39507542
88Increased intramyocellular lipid droplets (HP:0012240)2.39081254
89Anxiety (HP:0000739)2.38305273
90Lactic acidosis (HP:0003128)2.33688083
91Erythema (HP:0010783)2.31141070
92Pustule (HP:0200039)2.30835865
93Supraventricular arrhythmia (HP:0005115)2.30136280
94Difficulty running (HP:0009046)2.29166678
95Postural instability (HP:0002172)2.28113617
96Centrally nucleated skeletal muscle fibers (HP:0003687)2.27428366
97Distal lower limb amyotrophy (HP:0008944)2.26993024
98Progressive macrocephaly (HP:0004481)2.26641888
99Ventricular arrhythmia (HP:0004308)2.25397551
100Muscle fiber splitting (HP:0003555)2.25022811
101Areflexia of lower limbs (HP:0002522)2.24459807
102Poikilocytosis (HP:0004447)2.24408012
103Pheochromocytoma (HP:0002666)2.24372200
104Gout (HP:0001997)2.23906667
105Abnormal atrioventricular conduction (HP:0005150)2.22856800
106Elevated erythrocyte sedimentation rate (HP:0003565)2.22383881
107Spontaneous hematomas (HP:0007420)2.22146203
108Hyperventilation (HP:0002883)2.21469980
109Progressive muscle weakness (HP:0003323)2.21434118
110Urticaria (HP:0001025)2.21036696
111Neuroendocrine neoplasm (HP:0100634)2.19269512
112Papilledema (HP:0001085)2.18766192
113Abnormal pupillary function (HP:0007686)2.17928261
114Recurrent abscess formation (HP:0002722)2.17174693
115Ketoacidosis (HP:0001993)2.16811098
116Chronic obstructive pulmonary disease (HP:0006510)2.14885774
117Obstructive lung disease (HP:0006536)2.14885774
118Nemaline bodies (HP:0003798)2.14669143
119Dysdiadochokinesis (HP:0002075)2.14540224
120Subaortic stenosis (HP:0001682)2.12372500
121Abnormality of the left ventricular outflow tract (HP:0011103)2.12372500
122Autoimmune hemolytic anemia (HP:0001890)2.11739678
123Right ventricular cardiomyopathy (HP:0011663)2.09756524
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.09341859
125Abnormality of alanine metabolism (HP:0010916)2.09341859
126Hyperalaninemia (HP:0003348)2.09341859
127Increased IgM level (HP:0003496)2.06566596
128Cerebral edema (HP:0002181)2.06545932
129Bradykinesia (HP:0002067)2.06351146
130Oral leukoplakia (HP:0002745)2.04615342
131Emotional lability (HP:0000712)2.04381193
132Atrioventricular block (HP:0001678)2.04259301
133Asymmetric septal hypertrophy (HP:0001670)2.04192263
134Exercise intolerance (HP:0003546)2.03832826
135Limb-girdle muscle atrophy (HP:0003797)2.03342930
136Reticulocytosis (HP:0001923)2.01848967
137Abnormal EKG (HP:0003115)2.00393124
138Ketosis (HP:0001946)2.00240353
139Conjunctival hamartoma (HP:0100780)2.00232013
140Verrucae (HP:0200043)1.99722654
141Papilloma (HP:0012740)1.99722654
142Unsteady gait (HP:0002317)1.99357992
143Urinary urgency (HP:0000012)1.99191882
144Distal arthrogryposis (HP:0005684)1.98478744
145Meningitis (HP:0001287)1.96088158
146Inflammation of the large intestine (HP:0002037)1.95214911
147Broad-based gait (HP:0002136)1.93569846
148Abnormality of the heme biosynthetic pathway (HP:0010472)1.93508224
149Encephalitis (HP:0002383)1.93267254
150Lower limb amyotrophy (HP:0007210)1.92449676
151Gastrointestinal stroma tumor (HP:0100723)1.92445622
152Delusions (HP:0000746)1.92282790
153Increased serum lactate (HP:0002151)1.92028718
154Myopathic facies (HP:0002058)1.92021778
155Lipoatrophy (HP:0100578)1.91875247
156Hypotrichosis (HP:0001006)1.89673147
157Myositis (HP:0100614)1.87292278
158Vasculitis (HP:0002633)1.86572198
159Abnormality of the neuromuscular junction (HP:0003398)1.85586338
160Fatigable weakness (HP:0003473)1.85586338
161Joint swelling (HP:0001386)1.85468971
162Gastrointestinal inflammation (HP:0004386)1.84791094
163Abnormality of skeletal muscle fiber size (HP:0012084)1.84252696
164Supranuclear gaze palsy (HP:0000605)1.81472287
165Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.80731836
166Pili torti (HP:0003777)1.79226071
167Episodic fever (HP:0001954)1.77904218
168Bruising susceptibility (HP:0000978)1.76995528
169Agammaglobulinemia (HP:0004432)1.76902345
170Skin ulcer (HP:0200042)1.75900094
171Skin rash (HP:0000988)1.71793176
172Cellulitis (HP:0100658)1.71605898
173Amniotic constriction ring (HP:0009775)1.70987484
174Abnormality of placental membranes (HP:0011409)1.70987484
175Hyperthyroidism (HP:0000836)1.67945536
176Hypergammaglobulinemia (HP:0010702)1.66838290
177Chest pain (HP:0100749)1.66487816
178Abnormality of T cell physiology (HP:0011840)1.66449644
179Orchitis (HP:0100796)1.65764992
180Palmoplantar keratoderma (HP:0000982)1.64599376
181Recurrent fungal infections (HP:0002841)1.64505116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K123.83124678
2EPHA43.36192155
3MST43.21630369
4NEK12.78250534
5NTRK32.76293487
6CDK192.69461189
7MAP3K92.66724021
8DAPK12.48703279
9MAP2K42.40844792
10DAPK22.39258986
11MAP3K42.33097385
12RIPK42.28300119
13MAP4K12.18266361
14TTN2.03075453
15MAP2K71.99599204
16MINK11.95815370
17PHKG21.95106231
18PHKG11.95106231
19PDK31.89264961
20PDK41.89264961
21IRAK41.83073646
22BMX1.80840544
23ZAP701.78275228
24OBSCN1.77146972
25PINK11.75561651
26BTK1.75396584
27CAMKK11.75266448
28NME11.69437488
29KSR21.68238252
30TAOK11.65284591
31CAMKK21.57852734
32MAPKAPK31.56024366
33BCKDK1.55111817
34LMTK21.49421784
35TRIB31.48626422
36EPHB11.48361503
37ERN11.47449061
38FES1.47080791
39BMPR21.44617802
40CCNB11.41600704
41* SYK1.37849637
42TXK1.37011734
43MAP3K111.29904062
44PKN21.29465362
45MAP3K31.27235864
46GRK61.27146985
47ARAF1.25775694
48GRK51.25149924
49CSF1R1.21368978
50BLK1.19631217
51HCK1.19203833
52MYLK1.16345902
53MST1R1.15356407
54TAOK21.14166947
55PAK61.13763222
56MAP3K71.12109687
57TESK21.09705329
58TEC1.08185671
59STK241.06649383
60RAF11.06519201
61CAMK11.04433199
62JAK11.03119435
63MARK31.01712513
64MAP2K31.01184574
65EIF2AK11.00008395
66MAP3K10.99991999
67PDK10.98534584
68TESK10.98118115
69STK380.97837084
70IKBKB0.96487395
71EEF2K0.94705200
72CDK50.92825485
73MUSK0.92682763
74MAP2K60.90165603
75ITK0.89150646
76SIK30.88313175
77DAPK30.85734286
78TLK10.85420576
79CASK0.84627368
80MAP3K60.84391179
81CSK0.83977982
82SCYL20.83034619
83MAPK120.82610421
84PRKCG0.82578740
85TRPM70.82519439
86PDPK10.82044910
87TNK20.80933159
88PAK10.80545824
89IRAK30.80463569
90MAP3K50.78882058
91PTK2B0.78880807
92PIM20.74368592
93BRSK10.73625897
94FGR0.72847925
95JAK30.72099476
96CAMK40.70943265
97LYN0.70884328
98NTRK10.70154181
99CAMK2A0.69831196
100MOS0.69003861
101SMG10.68936082
102STK100.67784983
103MAP3K130.67574869
104PLK20.66970538
105MAP3K140.66909481
106TBK10.66816975
107PRKD30.66138399
108PIK3CG0.62691129
109IKBKE0.62540901
110PRKCQ0.61551684
111JAK20.61283627
112PDK20.58577071
113TAOK30.58080117
114STK110.57953903
115ALK0.56779167
116DMPK0.56334348
117CDK180.56214304
118CDK150.55894090
119SGK30.55063004
120IRAK20.54694087
121TSSK60.53340321
122LCK0.53139971
123CDK11A0.52282758
124RET0.51484437
125BRAF0.50796528
126HIPK20.50331732
127PRKCI0.49913752
128STK160.49379388
129SIK10.49148478
130CAMK2G0.48449213
131FYN0.48324503
132KSR10.47079759
133TNIK0.46543720
134UHMK10.46492226
135MAPKAPK50.46243461
136GRK70.45883748
137NTRK20.45762320
138CAMK2D0.45543025
139MAP2K10.45200445
140SGK20.44114813
141TYK20.43404141
142CDK140.41500373
143PRKG20.40213033
144PRPF4B0.39350651
145MAP3K80.38263764
146RIPK10.37599566
147ILK0.37434951
148SGK10.37197343
149PIM10.37143253
150MAPK110.36902768
151MAP3K20.35336542
152MAPK40.34850266
153RPS6KA30.34508929
154CAMK2B0.33982081

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.95484160
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46324595
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.20881043
4Synaptic vesicle cycle_Homo sapiens_hsa047212.93603394
5Platelet activation_Homo sapiens_hsa046112.79204742
6Cardiac muscle contraction_Homo sapiens_hsa042602.39466688
7Nicotine addiction_Homo sapiens_hsa050332.33492417
8Primary immunodeficiency_Homo sapiens_hsa053402.25913128
9Oxidative phosphorylation_Homo sapiens_hsa001902.23510890
10Long-term potentiation_Homo sapiens_hsa047202.21677010
11B cell receptor signaling pathway_Homo sapiens_hsa046622.20780533
12Parkinsons disease_Homo sapiens_hsa050122.16716304
13Olfactory transduction_Homo sapiens_hsa047402.15501209
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04869630
15SNARE interactions in vesicular transport_Homo sapiens_hsa041302.02277944
16Carbon metabolism_Homo sapiens_hsa012001.95260479
17Circadian entrainment_Homo sapiens_hsa047131.88737716
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88130574
19Amphetamine addiction_Homo sapiens_hsa050311.87891522
20T cell receptor signaling pathway_Homo sapiens_hsa046601.86904983
21* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79224819
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72777090
23Alzheimers disease_Homo sapiens_hsa050101.72478749
24Salivary secretion_Homo sapiens_hsa049701.72403674
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71853107
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68348129
27Gastric acid secretion_Homo sapiens_hsa049711.67034247
28Collecting duct acid secretion_Homo sapiens_hsa049661.63860426
29GABAergic synapse_Homo sapiens_hsa047271.62278652
30Hematopoietic cell lineage_Homo sapiens_hsa046401.61974101
31Biosynthesis of amino acids_Homo sapiens_hsa012301.60300008
32Calcium signaling pathway_Homo sapiens_hsa040201.57618678
33Chemokine signaling pathway_Homo sapiens_hsa040621.55845915
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55156297
35Nitrogen metabolism_Homo sapiens_hsa009101.54261041
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50674322
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49944565
38Glutamatergic synapse_Homo sapiens_hsa047241.47520703
39Morphine addiction_Homo sapiens_hsa050321.47302100
40Osteoclast differentiation_Homo sapiens_hsa043801.45051969
41Insulin secretion_Homo sapiens_hsa049111.43573015
42Pyruvate metabolism_Homo sapiens_hsa006201.42714100
43Shigellosis_Homo sapiens_hsa051311.40827110
44Arginine biosynthesis_Homo sapiens_hsa002201.39942757
45Oxytocin signaling pathway_Homo sapiens_hsa049211.39816494
46Dopaminergic synapse_Homo sapiens_hsa047281.37859175
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.35304714
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35107632
49Endocytosis_Homo sapiens_hsa041441.34037713
50Propanoate metabolism_Homo sapiens_hsa006401.30078370
51Graft-versus-host disease_Homo sapiens_hsa053321.28290287
52Allograft rejection_Homo sapiens_hsa053301.21278967
53Fructose and mannose metabolism_Homo sapiens_hsa000511.20944241
54Renin secretion_Homo sapiens_hsa049241.20201147
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19217070
56Type I diabetes mellitus_Homo sapiens_hsa049401.17720439
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.17706575
58Dilated cardiomyopathy_Homo sapiens_hsa054141.16919181
59Autoimmune thyroid disease_Homo sapiens_hsa053201.14924777
60Huntingtons disease_Homo sapiens_hsa050161.13560494
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11413769
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.10820498
63Tuberculosis_Homo sapiens_hsa051521.09757061
64Leishmaniasis_Homo sapiens_hsa051401.07988939
65Glucagon signaling pathway_Homo sapiens_hsa049221.07803706
66Pentose phosphate pathway_Homo sapiens_hsa000301.07538576
67Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05974813
68Fatty acid degradation_Homo sapiens_hsa000711.04093039
69Cholinergic synapse_Homo sapiens_hsa047251.03195891
70Taste transduction_Homo sapiens_hsa047421.03049751
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02289966
72GnRH signaling pathway_Homo sapiens_hsa049121.01053876
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00328060
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.98396699
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.98289547
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97005027
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.93117614
78Long-term depression_Homo sapiens_hsa047300.91728904
79Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90909355
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89470623
81Toxoplasmosis_Homo sapiens_hsa051450.89222953
82Measles_Homo sapiens_hsa051620.88962264
83Viral myocarditis_Homo sapiens_hsa054160.88444771
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87556025
85Alcoholism_Homo sapiens_hsa050340.87438250
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86908178
87Acute myeloid leukemia_Homo sapiens_hsa052210.82086197
88cAMP signaling pathway_Homo sapiens_hsa040240.80858910
89Galactose metabolism_Homo sapiens_hsa000520.80620375
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.80019152
91Antigen processing and presentation_Homo sapiens_hsa046120.76587209
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76389076
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75903478
94Insulin signaling pathway_Homo sapiens_hsa049100.75723639
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74705158
96Arachidonic acid metabolism_Homo sapiens_hsa005900.72699396
97Pancreatic secretion_Homo sapiens_hsa049720.70580657
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.70579001
99Pancreatic cancer_Homo sapiens_hsa052120.70074588
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69746953
101Cocaine addiction_Homo sapiens_hsa050300.68523635
102Systemic lupus erythematosus_Homo sapiens_hsa053220.66848197
103* Gap junction_Homo sapiens_hsa045400.65987365
104Starch and sucrose metabolism_Homo sapiens_hsa005000.65867485
105Vibrio cholerae infection_Homo sapiens_hsa051100.64567288
106Viral carcinogenesis_Homo sapiens_hsa052030.64344385
107VEGF signaling pathway_Homo sapiens_hsa043700.64282553
108Serotonergic synapse_Homo sapiens_hsa047260.64138425
109Type II diabetes mellitus_Homo sapiens_hsa049300.63785032
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63700468
111Bile secretion_Homo sapiens_hsa049760.63211381
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62397222
113Renal cell carcinoma_Homo sapiens_hsa052110.62282776
114Thyroid cancer_Homo sapiens_hsa052160.61720256
115Influenza A_Homo sapiens_hsa051640.59726045
116Oocyte meiosis_Homo sapiens_hsa041140.59522558
117* Apoptosis_Homo sapiens_hsa042100.58420628
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.57721287
119Glioma_Homo sapiens_hsa052140.56327066
120Estrogen signaling pathway_Homo sapiens_hsa049150.56081414
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.55595207
122Butanoate metabolism_Homo sapiens_hsa006500.55026253
123Malaria_Homo sapiens_hsa051440.54109483
124Fatty acid metabolism_Homo sapiens_hsa012120.54027588
125Salmonella infection_Homo sapiens_hsa051320.53573523
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53547486
127MAPK signaling pathway_Homo sapiens_hsa040100.52426613
128ErbB signaling pathway_Homo sapiens_hsa040120.51745788
129* Phagosome_Homo sapiens_hsa041450.49916930
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.48743714
131Circadian rhythm_Homo sapiens_hsa047100.48085449
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.46822712
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42939045
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42912359
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.42355956
136Thyroid hormone synthesis_Homo sapiens_hsa049180.41267879
137Phenylalanine metabolism_Homo sapiens_hsa003600.41071828
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37191164
139Sulfur relay system_Homo sapiens_hsa041220.35616986
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.35339964
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.35160787
142HIF-1 signaling pathway_Homo sapiens_hsa040660.33419092
143beta-Alanine metabolism_Homo sapiens_hsa004100.33063429
144Non-small cell lung cancer_Homo sapiens_hsa052230.32811896
145Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32158949
146Inositol phosphate metabolism_Homo sapiens_hsa005620.32083413
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31953767
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31599066
149Insulin resistance_Homo sapiens_hsa049310.30307410
150Vitamin B6 metabolism_Homo sapiens_hsa007500.28162151
151mTOR signaling pathway_Homo sapiens_hsa041500.27597904

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