ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	left/right pattern formation (GO:0060972)	8.88982516
2	regulation of cilium movement (GO:0003352)	8.01636159
3	primary alcohol catabolic process (GO:0034310)	7.60164037
4	vitamin transmembrane transport (GO:0035461)	7.00635721
5	left/right axis specification (GO:0070986)	6.87546532
6	ventricular system development (GO:0021591)	6.43690037
7	diterpenoid biosynthetic process (GO:0016102)	6.31893133
8	microtubule bundle formation (GO:0001578)	6.28217814
9	pyrimidine-containing compound transmembrane transport (GO:0072531)	6.23612296
10	ethanol metabolic process (GO:0006067)	6.22721584
11	intraciliary transport (GO:0042073)	6.02252372
12	cilium organization (GO:0044782)	5.88272694
13	cilium assembly (GO:0042384)	5.66770838
14	tolerance induction (GO:0002507)	5.55528205
15	centriole assembly (GO:0098534)	5.46108188
16	response to xenobiotic stimulus (GO:0009410)	5.25006466
17	one-carbon compound transport (GO:0019755)	5.21561923
18	negative regulation of T cell differentiation in thymus (GO:0033085)	5.01517666
19	protein localization to cilium (GO:0061512)	4.99270231
20	regulation of microtubule-based movement (GO:0060632)	4.87948653
21	lung epithelium development (GO:0060428)	4.87697541
22	sperm capacitation (GO:0048240)	4.76745963
23	ethanol oxidation (GO:0006069)	4.66574335
24	microtubule-based movement (GO:0007018)	4.57390032
25	regulation of germinal center formation (GO:0002634)	4.56887755
26	terpenoid biosynthetic process (GO:0016114)	4.48593312
27	negative regulation of B cell mediated immunity (GO:0002713)	4.47057699
28	negative regulation of immunoglobulin mediated immune response (GO:0002890)	4.47057699
29	cellular component assembly involved in morphogenesis (GO:0010927)	4.46697054
30	positive regulation of tolerance induction (GO:0002645)	4.41005944
31	glomerular epithelial cell development (GO:0072310)	4.34793431
32	regulation of interleukin-5 production (GO:0032674)	4.34295258
33	negative regulation of humoral immune response (GO:0002921)	4.31885306
34	retinoic acid metabolic process (GO:0042573)	4.23399301
35	establishment of apical/basal cell polarity (GO:0035089)	4.22252440
36	cilium morphogenesis (GO:0060271)	4.19856475
37	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.19080243
38	cell projection assembly (GO:0030031)	4.13866179
39	microtubule depolymerization (GO:0007019)	4.03669518
40	regulation of interleukin-13 production (GO:0032656)	3.97300221
41	nucleoside diphosphate phosphorylation (GO:0006165)	3.87607366
42	cytoplasmic microtubule organization (GO:0031122)	3.87603970
43	exogenous drug catabolic process (GO:0042738)	3.81611168
44	microtubule polymerization or depolymerization (GO:0031109)	3.79224592
45	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.78618580
46	establishment of monopolar cell polarity (GO:0061162)	3.60541429
47	establishment or maintenance of monopolar cell polarity (GO:0061339)	3.60541429
48	retinal cone cell development (GO:0046549)	3.44421487
49	primary alcohol metabolic process (GO:0034308)	3.40283102
50	O-glycan processing (GO:0016266)	3.34195485
51	retinol metabolic process (GO:0042572)	3.30565905
52	regulation of tolerance induction (GO:0002643)	3.26069181
53	multicellular organism reproduction (GO:0032504)	3.22950889
54	centriole replication (GO:0007099)	3.21700380
55	glutathione derivative metabolic process (GO:1901685)	3.13602252
56	glutathione derivative biosynthetic process (GO:1901687)	3.13602252
57	regulation of microtubule depolymerization (GO:0031114)	3.13142502
58	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.11265501
59	establishment of planar polarity (GO:0001736)	3.09903511
60	establishment of tissue polarity (GO:0007164)	3.09903511
61	lateral ventricle development (GO:0021670)	3.09102954
62	regulation of female gonad development (GO:2000194)	3.05352852
63	negative regulation of inclusion body assembly (GO:0090084)	3.05194936
64	multicellular organismal water homeostasis (GO:0050891)	3.02951186
65	sperm motility (GO:0030317)	3.01767413
66	axonemal dynein complex assembly (GO:0070286)	21.8951845
67	hydrogen peroxide biosynthetic process (GO:0050665)	2.99961438
68	drug catabolic process (GO:0042737)	2.92906997
69	aldehyde catabolic process (GO:0046185)	2.91103449
70	oligosaccharide biosynthetic process (GO:0009312)	2.85580203
71	determination of left/right symmetry (GO:0007368)	2.85274241
72	regulation of autophagic vacuole assembly (GO:2000785)	2.78449914
73	retinal rod cell development (GO:0046548)	2.76100705
74	lateral sprouting from an epithelium (GO:0060601)	2.75467322
75	determination of bilateral symmetry (GO:0009855)	2.73234911
76	positive regulation of smoothened signaling pathway (GO:0045880)	2.69767744
77	* microtubule-based process (GO:0007017)	2.67859953
78	water homeostasis (GO:0030104)	2.67178156
79	specification of symmetry (GO:0009799)	2.66525193
80	reactive oxygen species biosynthetic process (GO:1903409)	2.63586764
81	progesterone metabolic process (GO:0042448)	2.61650992
82	hypotonic response (GO:0006971)	2.59084950
83	organelle assembly (GO:0070925)	2.56755553
84	smoothened signaling pathway (GO:0007224)	2.55891283
85	excretion (GO:0007588)	2.55079320
86	carnitine metabolic process (GO:0009437)	2.54487161
87	negative regulation of microtubule depolymerization (GO:0007026)	2.52456652
88	regulation of vacuole organization (GO:0044088)	2.50496624
89	single fertilization (GO:0007338)	2.50495083
90	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	2.47866924
91	phosphatidylcholine biosynthetic process (GO:0006656)	2.46359476
92	protein O-linked glycosylation (GO:0006493)	2.46187079
93	sodium ion homeostasis (GO:0055078)	2.41113948
94	establishment or maintenance of apical/basal cell polarity (GO:0035088)	2.39969829
95	cilium or flagellum-dependent cell motility (GO:0001539)	17.8619222
96	cilium movement (GO:0003341)	15.6468226
97	motile cilium assembly (GO:0044458)	15.0096517
98	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	14.6424008
99	epithelial cilium movement (GO:0003351)	13.6469437
100	axoneme assembly (GO:0035082)	10.2991585

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.11500738
2	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.03881674
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.64864936
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.52563804
5	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.50218246
6	DROSHA_22980978_ChIP-Seq_HELA_Human	3.26912613
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.15208578
8	* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	3.00563071
9	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.15528199
10	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.08052851
11	STAT1_20625510_ChIP-Seq_HELA_Human	1.97173919
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.95844627
13	AHR_22903824_ChIP-Seq_MCF-7_Human	1.87758386
14	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.82559027
15	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.73022769
16	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.69655910
17	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.68799082
18	VDR_22108803_ChIP-Seq_LS180_Human	1.68584027
19	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.66139885
20	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.66020925
21	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.64212004
22	SMC4_20622854_ChIP-Seq_HELA_Human	1.63735685
23	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.61074239
24	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.60976270
25	RAD21_21589869_ChIP-Seq_MESCs_Mouse	1.59284970
26	TP63_23658742_ChIP-Seq_EP156T_Human	1.58805015
27	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.58347947
28	EZH2_22144423_ChIP-Seq_EOC_Human	1.58231457
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.54635821
30	SMRT_27268052_Chip-Seq_Bcells_Human	1.54004386
31	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.52351124
32	TP63_22573176_ChIP-Seq_HFKS_Human	1.49476670
33	* SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.45167582
34	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.44620769
35	ETV1_20927104_ChIP-Seq_GIST48_Human	1.44154452
36	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.40675145
37	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.39819595
38	CTCF_20526341_ChIP-Seq_ESCs_Human	1.38293659
39	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.37098496
40	PHF8_20622853_ChIP-Seq_HELA_Human	1.34514368
41	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.33689026
42	KLF5_25053715_ChIP-Seq_YYC3_Human	1.33592694
43	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.33448514
44	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.33160861
45	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29565671
46	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.29129006
47	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.28225841
48	RBPJ_21746931_ChIP-Seq_IB4_Human	1.27724633
49	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.25935089
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.25052504
51	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.23007716
52	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.22593452
53	GATA4_25053715_ChIP-Seq_YYC3_Human	1.22364641
54	SOX2_20726797_ChIP-Seq_SW620_Human	1.21347148
55	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.21059852
56	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19650925
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.19259716
58	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.17355316
59	TP53_18474530_ChIP-ChIP_U2OS_Human	1.16988998
60	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.16170264
61	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.16059798
62	CEBPB_22108803_ChIP-Seq_LS180_Human	1.15980384
63	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.15389112
64	SOX2_21211035_ChIP-Seq_LN229_Human	1.14605356
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14555086
66	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.11698388
67	AR_20517297_ChIP-Seq_VCAP_Human	1.11302593
68	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.10511199
69	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.10439598
70	* YY1_22570637_ChIP-Seq_MALME-3M_Human	1.09892410
71	* P68_20966046_ChIP-Seq_HELA_Human	1.09822952
72	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.09453703
73	* P300_27268052_Chip-Seq_Bcells_Human	1.08139679
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08026529
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08026529
76	* PHF8_20622854_ChIP-Seq_HELA_Human	1.06719562
77	GATA1_19941826_ChIP-Seq_K562_Human	1.06361902
78	NFYA_21822215_ChIP-Seq_K562_Human	1.05200282
79	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.03358664
80	NFYB_21822215_ChIP-Seq_K562_Human	1.03087707
81	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.02692762
82	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.02420067
83	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.98793600
84	* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98201262
85	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96833485
86	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.96683965
87	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	0.96349661
88	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.96309586
89	CBP_21632823_ChIP-Seq_H3396_Human	0.96057489
90	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.95924159
91	AR_21572438_ChIP-Seq_LNCaP_Human	0.95896896
92	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.95286952
93	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.95164280
94	TBL1_22424771_ChIP-Seq_293T_Human	0.94521784
95	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94269862
96	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.93809971
97	ERG_20517297_ChIP-Seq_VCAP_Human	0.93359269
98	CTCF_27219007_Chip-Seq_Bcells_Human	0.93024509
99	OCT4_20526341_ChIP-Seq_ESCs_Human	0.93007932
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92477204

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008875_abnormal_xenobiotic_pharmacok	6.90472867
2	MP0002653_abnormal_ependyma_morphology	5.87746609
3	MP0002132_abnormal_respiratory_system	4.94167496
4	MP0008789_abnormal_olfactory_epithelium	4.17569502
5	MP0001984_abnormal_olfaction	4.08871635
6	MP0004043_abnormal_pH_regulation	3.91541946
7	MP0002277_abnormal_respiratory_mucosa	3.53582194
8	MP0009780_abnormal_chondrocyte_physiolo	3.39683282
9	MP0005394_taste/olfaction_phenotype	2.95146069
10	MP0005499_abnormal_olfactory_system	2.95146069
11	MP0004133_heterotaxia	2.93245724
12	MP0005623_abnormal_meninges_morphology	2.69489406
13	MP0003718_maternal_effect	2.69010606
14	MP0000566_synostosis	2.54166855
15	MP0010234_abnormal_vibrissa_follicle	2.36959358
16	MP0010678_abnormal_skin_adnexa	2.17828850
17	MP0005395_other_phenotype	2.17819301
18	MP0002160_abnormal_reproductive_system	2.10084540
19	MP0000383_abnormal_hair_follicle	2.08822855
20	MP0002139_abnormal_hepatobiliary_system	2.04325703
21	MP0004019_abnormal_vitamin_homeostasis	2.02411425
22	MP0005377_hearing/vestibular/ear_phenot	2.00297341
23	MP0003878_abnormal_ear_physiology	2.00297341
24	MP0001765_abnormal_ion_homeostasis	1.86383219
25	MP0002168_other_aberrant_phenotype	1.80442008
26	MP0005083_abnormal_biliary_tract	1.77182410
27	MP0003656_abnormal_erythrocyte_physiolo	1.75306044
28	MP0002282_abnormal_trachea_morphology	1.58806006
29	MP0000678_abnormal_parathyroid_gland	1.52107089
30	MP0000465_gastrointestinal_hemorrhage	1.44589601
31	MP0001346_abnormal_lacrimal_gland	1.41383680
32	MP0010155_abnormal_intestine_physiology	1.37671848
33	MP0001929_abnormal_gametogenesis	1.32642700
34	MP0005389_reproductive_system_phenotype	1.30389058
35	MP0005636_abnormal_mineral_homeostasis	1.22625851
36	MP0010030_abnormal_orbit_morphology	1.20834825
37	MP0002909_abnormal_adrenal_gland	1.16931388
38	MP0002876_abnormal_thyroid_physiology	1.13373786
39	MP0005165_increased_susceptibility_to	1.12052035
40	MP0005085_abnormal_gallbladder_physiolo	1.09536788
41	MP0002233_abnormal_nose_morphology	1.07346922
42	MP0009379_abnormal_foot_pigmentation	0.99866934
43	MP0003950_abnormal_plasma_membrane	0.98019780
44	MP0003195_calcinosis	0.93084415
45	MP0002638_abnormal_pupillary_reflex	0.92643859
46	MP0002735_abnormal_chemical_nociception	0.92624013
47	MP0005248_abnormal_Harderian_gland	0.90984632
48	MP0005365_abnormal_bile_salt	0.90579330
49	MP0002249_abnormal_larynx_morphology	0.89675586
50	MP0002734_abnormal_mechanical_nocicepti	0.89005304
51	MP0005646_abnormal_pituitary_gland	0.88810900
52	MP0003698_abnormal_male_reproductive	0.88207655
53	MP0003890_abnormal_embryonic-extraembry	0.86453732
54	MP0009643_abnormal_urine_homeostasis	0.86020921
55	MP0003866_abnormal_defecation	0.85195873
56	MP0002136_abnormal_kidney_physiology	0.84354915
57	MP0002405_respiratory_system_inflammati	0.84178963
58	MP0005408_hypopigmentation	0.82729661
59	MP0002161_abnormal_fertility/fecundity	0.73284482
60	MP0001664_abnormal_digestion	0.72923159
61	MP0001666_abnormal_nutrient_absorption	0.72467684
62	MP0002098_abnormal_vibrissa_morphology	0.71892373
63	MP0001293_anophthalmia	0.69698384
64	MP0005387_immune_system_phenotype	0.68890171
65	MP0001790_abnormal_immune_system	0.68890171
66	MP0005551_abnormal_eye_electrophysiolog	0.68395779
67	MP0005310_abnormal_salivary_gland	0.67242889
68	MP0009765_abnormal_xenobiotic_induced	0.65876812
69	MP0001502_abnormal_circadian_rhythm	0.65687249
70	MP0000681_abnormal_thyroid_gland	0.64875907
71	MP0005164_abnormal_response_to	0.64546734
72	MP0003879_abnormal_hair_cell	0.63788188
73	MP0001485_abnormal_pinna_reflex	0.63585893
74	MP0009763_increased_sensitivity_to	0.61915385
75	MP0001324_abnormal_eye_pigmentation	0.61701131
76	MP0003699_abnormal_female_reproductive	0.60969133
77	MP0003303_peritoneal_inflammation	0.58436821
78	MP0003252_abnormal_bile_duct	0.57567372
79	MP0000026_abnormal_inner_ear	0.56960486
80	MP0000653_abnormal_sex_gland	0.53243788
81	MP0004264_abnormal_extraembryonic_tissu	0.53092305
82	MP0000467_abnormal_esophagus_morphology	0.53052849
83	MP0006082_CNS_inflammation	0.52660185
84	MP0010368_abnormal_lymphatic_system	0.52465192
85	MP0005253_abnormal_eye_physiology	0.52200131
86	MP0008872_abnormal_physiological_respon	0.51844054
87	MP0002928_abnormal_bile_duct	0.50325365
88	MP0003453_abnormal_keratinocyte_physiol	0.49388249
89	MP0003136_yellow_coat_color	0.48945069
90	MP0001963_abnormal_hearing_physiology	0.48539244
91	MP0001944_abnormal_pancreas_morphology	0.47466736
92	MP0000631_abnormal_neuroendocrine_gland	0.47248461
93	MP0005220_abnormal_exocrine_pancreas	0.46717005
94	MP0002210_abnormal_sex_determination	0.45643490
95	MP0005503_abnormal_tendon_morphology	0.44948978
96	MP0001879_abnormal_lymphatic_vessel	0.44619594
97	MP0009046_muscle_twitch	0.43400338
98	MP0002229_neurodegeneration	0.42911488
99	MP0000858_altered_metastatic_potential	0.42200415
100	MP0006036_abnormal_mitochondrial_physio	0.39772902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	8.06061253
2	Bronchiectasis (HP:0002110)	7.44963760
3	Nasal polyposis (HP:0100582)	6.74038094
4	Abnormality of the nasal mucosa (HP:0000433)	5.61932356
5	Infertility (HP:0000789)	4.62716863
6	Bronchitis (HP:0012387)	4.49144152
7	Recurrent sinusitis (HP:0011108)	4.38979337
8	Male infertility (HP:0003251)	4.20163564
9	Chronic sinusitis (HP:0011109)	4.14706524
10	Recurrent otitis media (HP:0000403)	3.91711024
11	Occipital encephalocele (HP:0002085)	3.41463036
12	Pancreatic fibrosis (HP:0100732)	3.35026320
13	True hermaphroditism (HP:0010459)	3.23494265
14	Hyperactive renin-angiotensin system (HP:0000841)	3.20157785
15	Chronic otitis media (HP:0000389)	2.94955060
16	Atelectasis (HP:0100750)	2.94312528
17	Molar tooth sign on MRI (HP:0002419)	2.76545919
18	Abnormality of midbrain morphology (HP:0002418)	2.76545919
19	Pancreatic cysts (HP:0001737)	2.75315173
20	Cystic liver disease (HP:0006706)	2.72404864
21	Nephronophthisis (HP:0000090)	2.63000868
22	Chronic hepatic failure (HP:0100626)	2.42271446
23	Postaxial foot polydactyly (HP:0001830)	2.36017802
24	Tubulointerstitial nephritis (HP:0001970)	2.17760833
25	Abnormality of the renal medulla (HP:0100957)	2.06391758
26	Recurrent bronchitis (HP:0002837)	2.03763646
27	Decreased circulating renin level (HP:0003351)	2.03282479
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	12.5412694
29	Abnormal respiratory motile cilium morphology (HP:0005938)	11.2044852
30	Abnormal respiratory epithelium morphology (HP:0012253)	11.2044852
31	Abnormal respiratory motile cilium physiology (HP:0012261)	11.0535523
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	11.0284620
33	Absent/shortened dynein arms (HP:0200106)	11.0284620
34	Abnormal ciliary motility (HP:0012262)	10.8019721
35	Rhinitis (HP:0012384)	10.2703842
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.99332609
37	Congenital hepatic fibrosis (HP:0002612)	1.96201573
38	Anencephaly (HP:0002323)	1.94118690
39	Renal salt wasting (HP:0000127)	1.86853005
40	Medial flaring of the eyebrow (HP:0010747)	1.83148050
41	Male pseudohermaphroditism (HP:0000037)	1.82462205
42	Bell-shaped thorax (HP:0001591)	1.73467942
43	Asplenia (HP:0001746)	1.65742758
44	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.65656365
45	Congenital primary aphakia (HP:0007707)	1.63847100
46	Hyperaldosteronism (HP:0000859)	1.61630893
47	Gait imbalance (HP:0002141)	1.60379800
48	Tubular atrophy (HP:0000092)	1.58591226
49	Absent frontal sinuses (HP:0002688)	1.57969922
50	Sclerocornea (HP:0000647)	1.57475894
51	Hyperkalemia (HP:0002153)	1.56239164
52	Nephropathy (HP:0000112)	1.55830071
53	Furrowed tongue (HP:0000221)	1.54579363
54	Oculomotor apraxia (HP:0000657)	1.54191040
55	Postaxial hand polydactyly (HP:0001162)	1.53900807
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.51812830
57	Median cleft lip (HP:0000161)	1.49833439
58	Abnormality of renin-angiotensin system (HP:0000847)	1.45220567
59	Nephrogenic diabetes insipidus (HP:0009806)	1.42747873
60	Supernumerary spleens (HP:0009799)	1.39848836
61	Lip pit (HP:0100267)	1.39302671
62	Abnormality of chloride homeostasis (HP:0011422)	1.30770738
63	Hypokalemic alkalosis (HP:0001949)	1.30136994
64	Aplasia of the musculature (HP:0100854)	1.29697383
65	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.28936154
66	Preaxial hand polydactyly (HP:0001177)	1.28729135
67	Cone-rod dystrophy (HP:0000548)	1.26335378
68	Abnormality of the distal phalanges of the toes (HP:0010182)	1.25759607
69	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	1.24682059
70	Hyponatremia (HP:0002902)	1.24194616
71	Decreased central vision (HP:0007663)	1.23804986
72	Tubulointerstitial abnormality (HP:0001969)	1.21540434
73	Glucose intolerance (HP:0000833)	1.17994978
74	Abdominal situs inversus (HP:0003363)	1.17727753
75	Abnormality of abdominal situs (HP:0011620)	1.17727753
76	Bifid scrotum (HP:0000048)	1.14941606
77	Fetal akinesia sequence (HP:0001989)	1.11916625
78	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.10980786
79	Short thorax (HP:0010306)	1.10850087
80	Hand muscle atrophy (HP:0009130)	1.10702482
81	Carpal bone hypoplasia (HP:0001498)	1.10432670
82	Genital tract atresia (HP:0001827)	1.07385345
83	Stage 5 chronic kidney disease (HP:0003774)	1.06934699
84	Poor coordination (HP:0002370)	1.05701333
85	Vaginal atresia (HP:0000148)	1.04150794
86	Popliteal pterygium (HP:0009756)	1.02203841
87	Vascular calcification (HP:0004934)	1.02181230
88	Abnormality of the renal cortex (HP:0011035)	1.01562653
89	Bile duct proliferation (HP:0001408)	1.01475227
90	Abnormal biliary tract physiology (HP:0012439)	1.01475227
91	Spinal muscular atrophy (HP:0007269)	1.01363970
92	Taurodontia (HP:0000679)	1.00354335
93	Abnormality of permanent molar morphology (HP:0011071)	1.00354335
94	Abnormality of the dental root (HP:0006486)	1.00354335
95	Short femoral neck (HP:0100864)	1.00166775
96	Abnormality of the frontal sinuses (HP:0002687)	0.99064567
97	Obstructive sleep apnea (HP:0002870)	0.99055731
98	Abnormal rod and cone electroretinograms (HP:0008323)	0.98211513
99	Retinitis pigmentosa (HP:0000510)	0.97711721
100	Spinal cord compression (HP:0002176)	0.97663995

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST4	6.11029477
2	EPHA2	4.50881745
3	MAPKAPK3	2.55240367
4	NME1	2.41258225
5	STK24	2.35706137
6	TTK	2.19129035
7	MAPK15	11.4554485
8	SMG1	1.85377018
9	TLK1	1.83748605
10	NEK6	1.71837154
11	CSK	1.59380731
12	ARAF	1.43927756
13	MAP3K2	1.40992880
14	BCR	1.39514610
15	MAP3K3	1.37035954
16	EEF2K	1.35058253
17	EPHB1	1.32304891
18	TESK1	1.31355560
19	PTK2B	1.29725409
20	PRKCI	1.23926526
21	STK10	1.12740137
22	AURKA	1.12357428
23	GRK6	1.11161556
24	LRRK2	1.10138918
25	EPHA3	1.06360252
26	MAP3K13	0.96639151
27	TBK1	0.95556275
28	TRPM7	0.92466965
29	STK16	0.84013516
30	MST1R	0.76232593
31	MAP3K12	0.73694108
32	MAP3K7	0.72955457
33	PRKCQ	0.72681172
34	STK38	0.69336102
35	CAMKK1	0.67903318
36	RIPK4	0.67184133
37	MARK2	0.63484132
38	ERBB3	0.56633846
39	CDK9	0.55956558
40	BRSK2	0.54594675
41	MAP3K4	0.53011715
42	ERBB2	0.51838727
43	ZAP70	0.49847921
44	IRAK1	0.47182672
45	CAMK2G	0.43363474
46	MET	0.42953714
47	PLK1	0.42491991
48	MAP2K2	0.41764838
49	PRKCD	0.40593446
50	GRK1	0.39932764
51	NLK	0.39273617
52	TXK	0.38858574
53	MAP4K2	0.35738107
54	MAP2K7	0.35734829
55	PAK1	0.35292663
56	PRKAA2	0.34538844
57	NEK9	0.33857702
58	MYLK	0.33267728
59	PDPK1	0.32671398
60	PRKACA	0.29088598
61	MAP3K9	0.28797611
62	LATS1	0.28689921
63	TAOK3	0.27737653
64	SGK1	0.27177437
65	IKBKE	0.25754001
66	PRKCA	0.25567484
67	OXSR1	0.24205467
68	CDC42BPA	0.23935929
69	PBK	0.23455515
70	AKT2	0.22798329
71	STK39	0.21975414
72	PIM2	0.21753906
73	PNCK	0.21702425
74	CHUK	0.20538397
75	CDK12	0.20408054
76	EGFR	0.20320209
77	MAPKAPK5	0.19603148
78	FER	0.19169486
79	LMTK2	0.18444650
80	ABL1	0.17828449
81	CAMK2A	0.17629266
82	ROCK1	0.17627040
83	DYRK1B	0.17498727
84	MUSK	0.16868140
85	RPS6KB2	0.16847287
86	FYN	0.16629293
87	TAOK1	0.16198115
88	IGF1R	0.15938252
89	MELK	0.15419098
90	WNK4	0.14944865
91	MAP3K8	0.14426310
92	PRKCZ	0.13910682
93	HIPK2	0.13119315
94	PDK1	0.12659974
95	LIMK1	0.12294179
96	MATK	0.12223493
97	CHEK2	0.10813965
98	RIPK1	0.10398831
99	STK38L	0.10023243
100	CAMKK2	0.09647018

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	5.59710142
2	Phenylalanine metabolism_Homo sapiens_hsa00360	4.96783131
3	Histidine metabolism_Homo sapiens_hsa00340	4.64909696
4	Chemical carcinogenesis_Homo sapiens_hsa05204	4.64286082
5	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	4.29631717
6	Tyrosine metabolism_Homo sapiens_hsa00350	3.95685348
7	beta-Alanine metabolism_Homo sapiens_hsa00410	3.08464875
8	Caffeine metabolism_Homo sapiens_hsa00232	2.96896227
9	Huntingtons disease_Homo sapiens_hsa05016	2.80133393
10	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.70097375
11	Retinol metabolism_Homo sapiens_hsa00830	2.55206125
12	Glutathione metabolism_Homo sapiens_hsa00480	2.47598561
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.17245932
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.95772737
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.59425541
16	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.57626197
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.50457940
18	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.44125558
19	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.43666488
20	Circadian rhythm_Homo sapiens_hsa04710	1.39551393
21	ABC transporters_Homo sapiens_hsa02010	1.37973086
22	Sphingolipid metabolism_Homo sapiens_hsa00600	1.34855153
23	Peroxisome_Homo sapiens_hsa04146	1.22848797
24	Fatty acid degradation_Homo sapiens_hsa00071	1.12765490
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.12175681
26	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07048718
27	Tight junction_Homo sapiens_hsa04530	1.05920647
28	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.04899991
29	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.96360056
30	Salivary secretion_Homo sapiens_hsa04970	0.88165734
31	Olfactory transduction_Homo sapiens_hsa04740	0.84590453
32	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81587973
33	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.81551044
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.78498114
35	Taste transduction_Homo sapiens_hsa04742	0.76335427
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.72327416
37	Collecting duct acid secretion_Homo sapiens_hsa04966	0.70582876
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.69270630
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.66237297
40	Phototransduction_Homo sapiens_hsa04744	0.65337226
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59296077
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.58441284
43	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.51707320
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.47643258
45	Notch signaling pathway_Homo sapiens_hsa04330	0.46033579
46	Hepatitis C_Homo sapiens_hsa05160	0.45643064
47	Complement and coagulation cascades_Homo sapiens_hsa04610	0.45579246
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.45030009
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.43826360
50	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.38951961
51	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.38940324
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.37179403
53	Metabolic pathways_Homo sapiens_hsa01100	0.37020202
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36854778
55	Nicotine addiction_Homo sapiens_hsa05033	0.35443899
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.35201337
57	Choline metabolism in cancer_Homo sapiens_hsa05231	0.34284132
58	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.33346994
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.31993598
60	Allograft rejection_Homo sapiens_hsa05330	0.31531662
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.30464996
62	Antigen processing and presentation_Homo sapiens_hsa04612	0.29591771
63	Graft-versus-host disease_Homo sapiens_hsa05332	0.29458854
64	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.29364427
65	Basal transcription factors_Homo sapiens_hsa03022	0.28582476
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.28334525
67	Bile secretion_Homo sapiens_hsa04976	0.28019905
68	Serotonergic synapse_Homo sapiens_hsa04726	0.27773378
69	Type I diabetes mellitus_Homo sapiens_hsa04940	0.27662305
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27616940
71	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26326605
72	PPAR signaling pathway_Homo sapiens_hsa03320	0.25155774
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24705336
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23849057
75	Cocaine addiction_Homo sapiens_hsa05030	0.22875339
76	p53 signaling pathway_Homo sapiens_hsa04115	0.22785908
77	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.21865438
78	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.21713575
79	Purine metabolism_Homo sapiens_hsa00230	0.20812182
80	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.20482138
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.19107707
82	cAMP signaling pathway_Homo sapiens_hsa04024	0.18547037
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18418944
84	Adherens junction_Homo sapiens_hsa04520	0.18163927
85	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.17936792
86	Phagosome_Homo sapiens_hsa04145	0.17896926
87	Primary immunodeficiency_Homo sapiens_hsa05340	0.14901858
88	Asthma_Homo sapiens_hsa05310	0.14414110
89	Pyruvate metabolism_Homo sapiens_hsa00620	0.13097944
90	Butanoate metabolism_Homo sapiens_hsa00650	0.13097918
91	Regulation of autophagy_Homo sapiens_hsa04140	0.13070567
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.11218110
93	Arginine biosynthesis_Homo sapiens_hsa00220	0.11033450
94	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.10725294
95	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.10623448
96	Nitrogen metabolism_Homo sapiens_hsa00910	0.08668137
97	Cardiac muscle contraction_Homo sapiens_hsa04260	0.08028247
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.07133481
99	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.07082726
100	Amphetamine addiction_Homo sapiens_hsa05031	0.06846458

TUBA4B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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