TUBAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.26646156
2water-soluble vitamin biosynthetic process (GO:0042364)5.82499349
3DNA deamination (GO:0045006)4.73923311
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03863800
5establishment of protein localization to mitochondrial membrane (GO:0090151)3.91192126
6protein complex biogenesis (GO:0070271)3.87777104
7ATP synthesis coupled proton transport (GO:0015986)3.83408380
8energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83408380
9coenzyme catabolic process (GO:0009109)3.82932769
10cullin deneddylation (GO:0010388)3.80995164
11negative regulation of telomere maintenance (GO:0032205)3.79828418
12platelet dense granule organization (GO:0060155)3.79142600
13sulfation (GO:0051923)3.74275080
14nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67836215
15positive regulation of growth hormone secretion (GO:0060124)3.65447809
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.65308471
17NADH dehydrogenase complex assembly (GO:0010257)3.65308471
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.65308471
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58731825
20mitochondrial respiratory chain complex assembly (GO:0033108)3.58052019
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.54254654
22response to pheromone (GO:0019236)3.53336223
23DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.42633916
24kynurenine metabolic process (GO:0070189)3.41792966
25protein deneddylation (GO:0000338)3.41642958
26DNA damage response, detection of DNA damage (GO:0042769)3.41093951
27adaptation of signaling pathway (GO:0023058)3.38007959
28growth hormone secretion (GO:0030252)3.33739519
29inositol phosphate catabolic process (GO:0071545)3.33151250
30respiratory chain complex IV assembly (GO:0008535)3.31587969
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31462095
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31462095
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31462095
34regulation of cellular amino acid metabolic process (GO:0006521)3.30096618
35positive regulation of prostaglandin secretion (GO:0032308)3.29699708
36signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29618690
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29618690
38DNA ligation (GO:0006266)3.28112785
39cytidine metabolic process (GO:0046087)3.27488876
40cytidine catabolic process (GO:0006216)3.27488876
41cytidine deamination (GO:0009972)3.27488876
42termination of RNA polymerase III transcription (GO:0006386)3.24943220
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.24943220
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22994043
45DNA catabolic process, exonucleolytic (GO:0000738)3.18179988
46regulation of chronic inflammatory response (GO:0002676)3.18072415
47somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13974425
48somatic hypermutation of immunoglobulin genes (GO:0016446)3.13974425
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.10703854
50signal transduction involved in DNA integrity checkpoint (GO:0072401)3.10627697
51signal transduction involved in DNA damage checkpoint (GO:0072422)3.10627697
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07202655
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.06805157
54DNA double-strand break processing (GO:0000729)3.05595471
55maturation of 5.8S rRNA (GO:0000460)3.01464634
56protein-cofactor linkage (GO:0018065)2.99769148
57opioid receptor signaling pathway (GO:0038003)2.95147062
58RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93087807
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92886956
60phosphorylated carbohydrate dephosphorylation (GO:0046838)2.92407668
61inositol phosphate dephosphorylation (GO:0046855)2.92407668
62electron transport chain (GO:0022900)2.86787356
63respiratory electron transport chain (GO:0022904)2.86454721
64tryptophan catabolic process (GO:0006569)2.82564569
65indole-containing compound catabolic process (GO:0042436)2.82564569
66indolalkylamine catabolic process (GO:0046218)2.82564569
67rRNA modification (GO:0000154)2.82383291
68sequestering of actin monomers (GO:0042989)2.81866452
69mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77383666
70GTP biosynthetic process (GO:0006183)2.74462362
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74259533
72protein localization to cilium (GO:0061512)2.72143638
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.70890788
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.70635065
75negative regulation of ligase activity (GO:0051352)2.70635065
76proton transport (GO:0015992)2.70281658
77transmission of nerve impulse (GO:0019226)2.69112179
78intracellular protein transmembrane import (GO:0044743)2.68139586
79RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.67070470
80tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.67070470
81positive regulation of ligase activity (GO:0051351)2.65975200
82organelle disassembly (GO:1903008)2.65973554
83cytochrome complex assembly (GO:0017004)2.65811210
84establishment of integrated proviral latency (GO:0075713)2.65554775
85DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64880446
86hydrogen transport (GO:0006818)2.63967129
87negative regulation of membrane potential (GO:0045837)2.63308185
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.62066551
89resolution of meiotic recombination intermediates (GO:0000712)2.61794453
90regulation of prostaglandin secretion (GO:0032306)2.59964249
91positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.59323237
92telomere maintenance via telomerase (GO:0007004)2.58862174
93protein neddylation (GO:0045116)2.57958137
94hydrogen ion transmembrane transport (GO:1902600)2.57706699
95protein localization to mitochondrion (GO:0070585)2.57161945
96mannosylation (GO:0097502)2.55182042
97replication fork processing (GO:0031297)2.54705665
98tryptophan metabolic process (GO:0006568)2.54659295
99ribosome assembly (GO:0042255)2.54094210
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.53521704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human4.68148617
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44428847
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.86056680
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.84187753
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.52184364
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11262116
7ZNF274_21170338_ChIP-Seq_K562_Hela3.01769908
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.61006170
9VDR_22108803_ChIP-Seq_LS180_Human2.46317364
10TAF15_26573619_Chip-Seq_HEK293_Human2.39463670
11VDR_23849224_ChIP-Seq_CD4+_Human2.38687438
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.34051662
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29209517
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.24844371
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08579669
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97343200
17ELK1_19687146_ChIP-ChIP_HELA_Human1.94234511
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91845674
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89653084
20IGF1R_20145208_ChIP-Seq_DFB_Human1.89237685
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.87698491
22MYC_18940864_ChIP-ChIP_HL60_Human1.86143873
23EWS_26573619_Chip-Seq_HEK293_Human1.85844447
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84202690
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.82589236
26YY1_21170310_ChIP-Seq_MESCs_Mouse1.77835095
27FOXP3_21729870_ChIP-Seq_TREG_Human1.76436318
28P300_19829295_ChIP-Seq_ESCs_Human1.68050276
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66684045
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62526651
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57826107
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56405217
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50608949
34FUS_26573619_Chip-Seq_HEK293_Human1.47972555
35HTT_18923047_ChIP-ChIP_STHdh_Human1.47803952
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44406115
37GBX2_23144817_ChIP-Seq_PC3_Human1.42701813
38TP53_22573176_ChIP-Seq_HFKS_Human1.40195224
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39772097
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.39688094
41DCP1A_22483619_ChIP-Seq_HELA_Human1.38433988
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38243681
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32945830
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31228599
45CBP_20019798_ChIP-Seq_JUKART_Human1.29711257
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29711257
47GABP_19822575_ChIP-Seq_HepG2_Human1.28728227
48ER_23166858_ChIP-Seq_MCF-7_Human1.26881465
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.26606091
50SALL4_22934838_ChIP-ChIP_CD34+_Human1.25771033
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24819101
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24234266
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.23570727
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23570727
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22375217
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21815853
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16782352
58AR_20517297_ChIP-Seq_VCAP_Human1.16705678
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16008904
60FOXH1_21741376_ChIP-Seq_EPCs_Human1.13326386
61IRF1_19129219_ChIP-ChIP_H3396_Human1.11651852
62NANOG_19829295_ChIP-Seq_ESCs_Human1.11304488
63SOX2_19829295_ChIP-Seq_ESCs_Human1.11304488
64BCAT_22108803_ChIP-Seq_LS180_Human1.10395903
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.10301434
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.07759234
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07695347
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07205825
69NCOR_22424771_ChIP-Seq_293T_Human1.05407587
70IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02919029
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01971781
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.01306755
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00359287
74PHF8_20622853_ChIP-Seq_HELA_Human1.00274832
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.00032952
76GATA3_21878914_ChIP-Seq_MCF-7_Human0.99733768
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99358818
78NOTCH1_21737748_ChIP-Seq_TLL_Human0.98681882
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97908942
80NFE2_27457419_Chip-Seq_LIVER_Mouse0.97010643
81PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96721309
82TCF4_22108803_ChIP-Seq_LS180_Human0.96009095
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95484829
84ELK1_22589737_ChIP-Seq_MCF10A_Human0.94793579
85RBPJ_21746931_ChIP-Seq_IB4_Human0.93972395
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93517595
87SALL1_21062744_ChIP-ChIP_HESCs_Human0.91494417
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91312243
89AR_25329375_ChIP-Seq_VCAP_Human0.90614532
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90359771
91JUN_21703547_ChIP-Seq_K562_Human0.90110384
92REST_21632747_ChIP-Seq_MESCs_Mouse0.89159641
93ETV1_20927104_ChIP-Seq_GIST48_Human0.89133722
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88566438
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87935568
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87860589
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86937709
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86921842
99GATA3_26560356_Chip-Seq_TH2_Human0.86785518
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.86204578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.45178145
2MP0001529_abnormal_vocalization3.22049453
3MP0002736_abnormal_nociception_after3.13192420
4MP0001501_abnormal_sleep_pattern3.08117352
5MP0001968_abnormal_touch/_nociception2.84647773
6MP0002822_catalepsy2.82877441
7MP0008875_abnormal_xenobiotic_pharmacok2.82763854
8MP0000015_abnormal_ear_pigmentation2.79398287
9MP0003787_abnormal_imprinting2.60549878
10MP0010386_abnormal_urinary_bladder2.51990686
11MP0008058_abnormal_DNA_repair2.41520294
12MP0001984_abnormal_olfaction2.40085408
13MP0006276_abnormal_autonomic_nervous2.34020660
14MP0002909_abnormal_adrenal_gland2.25331628
15MP0000372_irregular_coat_pigmentation2.09771302
16MP0008872_abnormal_physiological_respon2.09715932
17MP0005551_abnormal_eye_electrophysiolog2.05649984
18MP0003011_delayed_dark_adaptation2.01802022
19MP0006072_abnormal_retinal_apoptosis1.97319868
20MP0008877_abnormal_DNA_methylation1.94281158
21MP0006035_abnormal_mitochondrial_morpho1.90705493
22MP0005084_abnormal_gallbladder_morpholo1.82834823
23MP0005253_abnormal_eye_physiology1.80385099
24MP0006036_abnormal_mitochondrial_physio1.76049200
25MP0005171_absent_coat_pigmentation1.72942010
26MP0003718_maternal_effect1.72049559
27MP0008789_abnormal_olfactory_epithelium1.71839397
28MP0009046_muscle_twitch1.66654626
29MP0003136_yellow_coat_color1.65563582
30MP0003786_premature_aging1.64397252
31MP0001764_abnormal_homeostasis1.44374629
32MP0005085_abnormal_gallbladder_physiolo1.42796972
33MP0004145_abnormal_muscle_electrophysio1.42591743
34MP0009745_abnormal_behavioral_response1.42148170
35MP0002837_dystrophic_cardiac_calcinosis1.41701486
36MP0002638_abnormal_pupillary_reflex1.38786087
37MP0001485_abnormal_pinna_reflex1.36804729
38MP0002277_abnormal_respiratory_mucosa1.34344796
39MP0005499_abnormal_olfactory_system1.32790303
40MP0005394_taste/olfaction_phenotype1.32790303
41MP0002272_abnormal_nervous_system1.31771300
42MP0005408_hypopigmentation1.26319876
43MP0002938_white_spotting1.24909235
44MP0003693_abnormal_embryo_hatching1.23897190
45MP0001905_abnormal_dopamine_level1.22451982
46MP0001486_abnormal_startle_reflex1.20687948
47MP0000569_abnormal_digit_pigmentation1.17957011
48MP0004924_abnormal_behavior1.16065521
49MP0005386_behavior/neurological_phenoty1.16065521
50MP0004142_abnormal_muscle_tone1.13931590
51MP0005671_abnormal_response_to1.13515512
52MP0002095_abnormal_skin_pigmentation1.10464004
53MP0004084_abnormal_cardiac_muscle1.09247471
54MP0005646_abnormal_pituitary_gland1.08961415
55MP0010094_abnormal_chromosome_stability1.08870562
56MP0002557_abnormal_social/conspecific_i1.04890852
57MP0004885_abnormal_endolymph1.03359857
58MP0005174_abnormal_tail_pigmentation1.01226247
59MP0002876_abnormal_thyroid_physiology1.00356567
60MP0002229_neurodegeneration1.00074519
61MP0004381_abnormal_hair_follicle0.95893687
62MP0004215_abnormal_myocardial_fiber0.95140308
63MP0003186_abnormal_redox_activity0.94945081
64MP0005075_abnormal_melanosome_morpholog0.94742157
65MP0003880_abnormal_central_pattern0.92950300
66MP0003635_abnormal_synaptic_transmissio0.92003838
67MP0002733_abnormal_thermal_nociception0.91118778
68MP0004742_abnormal_vestibular_system0.87908523
69MP0000631_abnormal_neuroendocrine_gland0.86251055
70MP0003119_abnormal_digestive_system0.85510189
71MP0003806_abnormal_nucleotide_metabolis0.85149276
72MP0003137_abnormal_impulse_conducting0.83074941
73MP0001348_abnormal_lacrimal_gland0.82930133
74MP0002572_abnormal_emotion/affect_behav0.81926832
75MP0005248_abnormal_Harderian_gland0.81618549
76MP0002064_seizures0.80369809
77MP0002693_abnormal_pancreas_physiology0.78626244
78MP0001970_abnormal_pain_threshold0.78410780
79MP0002067_abnormal_sensory_capabilities0.77759762
80MP0001502_abnormal_circadian_rhythm0.77662044
81MP0004147_increased_porphyrin_level0.74839635
82MP0003111_abnormal_nucleus_morphology0.72796719
83MP0002090_abnormal_vision0.72419970
84MP0001664_abnormal_digestion0.70418366
85MP0005332_abnormal_amino_acid0.69266616
86MP0008004_abnormal_stomach_pH0.68536711
87MP0005410_abnormal_fertilization0.67476210
88MP0001929_abnormal_gametogenesis0.67093095
89MP0003195_calcinosis0.67078425
90MP0003121_genomic_imprinting0.66927687
91MP0001881_abnormal_mammary_gland0.66850282
92MP0008995_early_reproductive_senescence0.66792353
93MP0002734_abnormal_mechanical_nocicepti0.65002490
94MP0000358_abnormal_cell_content/0.64547043
95MP0002177_abnormal_outer_ear0.64459182
96MP0004957_abnormal_blastocyst_morpholog0.64362487
97MP0002751_abnormal_autonomic_nervous0.63994599
98MP0000639_abnormal_adrenal_gland0.63499843
99MP0001963_abnormal_hearing_physiology0.63153028
100MP0003252_abnormal_bile_duct0.63041288

Predicted human phenotypes

RankGene SetZ-score
1Renal cortical cysts (HP:0000803)4.06305142
2Sensory axonal neuropathy (HP:0003390)3.92060301
3Abnormality of the renal cortex (HP:0011035)3.84055550
4Acute necrotizing encephalopathy (HP:0006965)3.67755799
5Hepatocellular necrosis (HP:0001404)3.67752529
6Hepatic necrosis (HP:0002605)3.61950226
7Abnormal mitochondria in muscle tissue (HP:0008316)3.45557244
8Mitochondrial inheritance (HP:0001427)3.39904023
9Acute encephalopathy (HP:0006846)3.37704134
10Methylmalonic acidemia (HP:0002912)3.34774111
11Progressive macrocephaly (HP:0004481)3.33602667
12Increased CSF lactate (HP:0002490)3.19621243
13Hyperglycinemia (HP:0002154)3.18818531
14Retinal dysplasia (HP:0007973)3.07658984
15Cerebral hypomyelination (HP:0006808)3.05111091
16Pancreatic cysts (HP:0001737)2.85743178
17Abolished electroretinogram (ERG) (HP:0000550)2.75556648
18Nephronophthisis (HP:0000090)2.73470336
19Volvulus (HP:0002580)2.70617558
20Increased hepatocellular lipid droplets (HP:0006565)2.70394368
21Lipid accumulation in hepatocytes (HP:0006561)2.69272783
22Degeneration of anterior horn cells (HP:0002398)2.68808841
23Abnormality of the anterior horn cell (HP:0006802)2.68808841
24Congenital sensorineural hearing impairment (HP:0008527)2.65791701
25Leukodystrophy (HP:0002415)2.63522456
26Optic disc pallor (HP:0000543)2.58273535
27Methylmalonic aciduria (HP:0012120)2.55290251
28Progressive inability to walk (HP:0002505)2.54726782
29Inability to walk (HP:0002540)2.51294090
30Cerebral edema (HP:0002181)2.51120236
31Lissencephaly (HP:0001339)2.50451297
32Renal Fanconi syndrome (HP:0001994)2.48872144
33Pancytopenia (HP:0001876)2.46728370
34Cerebellar dysplasia (HP:0007033)2.43784964
35Abnormality of the renal medulla (HP:0100957)2.42248923
36Increased serum lactate (HP:0002151)2.38668023
37Palpebral edema (HP:0100540)2.35106887
38Adrenal hypoplasia (HP:0000835)2.34585191
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31540946
40Focal motor seizures (HP:0011153)2.29243080
41CNS hypomyelination (HP:0003429)2.29226999
42Delayed CNS myelination (HP:0002188)2.22099677
43Cutaneous melanoma (HP:0012056)2.19509510
44Lactic acidosis (HP:0003128)2.19185343
45Abnormality of the labia minora (HP:0012880)2.18486359
46Type II lissencephaly (HP:0007260)2.18443481
47Aplastic anemia (HP:0001915)2.17482212
48Prostate neoplasm (HP:0100787)2.15080413
49Tubulointerstitial fibrosis (HP:0005576)2.12189720
50Abnormal drinking behavior (HP:0030082)2.10758707
51Polydipsia (HP:0001959)2.10758707
52Abnormality of midbrain morphology (HP:0002418)2.10551931
53Molar tooth sign on MRI (HP:0002419)2.10551931
54Hypoplastic pelvis (HP:0008839)2.09447238
55Abnormality of glycine metabolism (HP:0010895)2.08139076
56Abnormality of serine family amino acid metabolism (HP:0010894)2.08139076
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.07608009
58Hypoplasia of the fovea (HP:0007750)2.07608009
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.07485543
60Oral leukoplakia (HP:0002745)2.05253231
61Attenuation of retinal blood vessels (HP:0007843)2.03559598
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01713652
63Abnormality of alanine metabolism (HP:0010916)2.01713652
64Hyperalaninemia (HP:0003348)2.01713652
65Tubular atrophy (HP:0000092)2.01539211
66CNS demyelination (HP:0007305)2.00106392
67Pancreatic fibrosis (HP:0100732)1.99683524
68Abnormality of serum amino acid levels (HP:0003112)1.97011462
693-Methylglutaconic aciduria (HP:0003535)1.94911536
70Abnormality of the vitamin B12 metabolism (HP:0004341)1.94618043
71True hermaphroditism (HP:0010459)1.94354380
72Aplasia/hypoplasia of the uterus (HP:0008684)1.92889880
73Increased intramyocellular lipid droplets (HP:0012240)1.92618456
74Limb hypertonia (HP:0002509)1.92592845
75Congenital stationary night blindness (HP:0007642)1.91006516
76IgG deficiency (HP:0004315)1.90617993
77Generalized aminoaciduria (HP:0002909)1.89610443
78Exertional dyspnea (HP:0002875)1.88503642
79Tinnitus (HP:0000360)1.85662109
80Neuroendocrine neoplasm (HP:0100634)1.85368915
81Lethargy (HP:0001254)1.84456899
82Pheochromocytoma (HP:0002666)1.84150883
83Respiratory failure (HP:0002878)1.83410180
84Abnormality of vitamin B metabolism (HP:0004340)1.82931595
85Neoplasm of the adrenal gland (HP:0100631)1.82626522
86Hypothermia (HP:0002045)1.81769356
87Pendular nystagmus (HP:0012043)1.81483126
88Polyuria (HP:0000103)1.81328065
89Abnormality of the fovea (HP:0000493)1.81207379
90Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79380306
91Delayed gross motor development (HP:0002194)1.79346182
92Decreased central vision (HP:0007663)1.79012315
93Glycosuria (HP:0003076)1.78530920
94Abnormality of urine glucose concentration (HP:0011016)1.78530920
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.76603588
96Epileptic encephalopathy (HP:0200134)1.71365453
97Albinism (HP:0001022)1.70611128
98Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70597029
99Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70597029
100Hypoproteinemia (HP:0003075)1.69995253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.36630973
2MAP3K123.22266287
3VRK23.21297569
4BCKDK2.90110503
5BUB12.74723450
6PBK2.51809459
7TSSK62.42938628
8STK162.35715834
9EIF2AK12.29655061
10VRK12.28847980
11TLK12.23989001
12WNK32.22115209
13EIF2AK32.21952562
14ZAK2.08859305
15DAPK12.08119141
16MST41.99009875
17FRK1.97903729
18TRIM281.80813717
19PINK11.80739480
20MAP4K21.77070426
21DYRK21.76834044
22SRPK11.56789711
23CSNK1G31.51329218
24BMPR1B1.49897939
25MYLK1.47532201
26PLK31.45704794
27MARK11.43035048
28PLK21.39401713
29CSNK1G21.38278552
30MAPK131.37102120
31BCR1.36189398
32TAF11.32074865
33CSNK1A1L1.31381425
34MAP3K41.30729575
35CCNB11.30141901
36GRK11.26850140
37WNK41.24796083
38CSNK1G11.23490283
39NUAK11.20306298
40TXK1.17603081
41INSRR1.10153729
42STK391.00128966
43TAOK30.98223045
44PAK30.95628370
45ERBB30.91662927
46CDK80.90240458
47NEK10.88628987
48TESK20.88541741
49OXSR10.85698222
50RPS6KA40.78216325
51SIK30.77195784
52AKT30.77061199
53STK40.76973117
54TNIK0.75549311
55PRKCE0.75336633
56PHKG20.72762884
57PHKG10.72762884
58CAMKK20.72626517
59TIE10.67027864
60ADRBK10.66983643
61MAPKAPK50.63303264
62MINK10.61490211
63KDR0.60130427
64RPS6KA50.60077252
65DAPK20.57548991
66MAPKAPK30.57356224
67PLK10.56879657
68MARK30.56443448
69EIF2AK20.55632472
70BRSK20.54772105
71LIMK10.53856303
72BRSK10.53309854
73CASK0.52892219
74PTK2B0.52847032
75PDK20.51389242
76ATR0.49662179
77MAP2K70.49428393
78FER0.48721972
79PRKCG0.46246464
80PRKCI0.43827721
81GRK50.42021494
82IKBKE0.40938005
83IGF1R0.39579475
84PKN10.39423200
85TGFBR10.38902199
86MET0.38645188
87MAP3K60.36430301
88IKBKB0.35778097
89SYK0.34942574
90CAMK2A0.34256733
91PLK40.34078797
92PIM20.33153864
93MKNK10.32729568
94CSNK2A10.31285860
95DAPK30.30952028
96NEK90.30638335
97CSNK1A10.28796722
98KIT0.28523554
99PRKG10.27010410
100STK38L0.25836734

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29265438
2Oxidative phosphorylation_Homo sapiens_hsa001903.19935490
3Non-homologous end-joining_Homo sapiens_hsa034502.83082579
4Parkinsons disease_Homo sapiens_hsa050122.75609494
5Protein export_Homo sapiens_hsa030602.74616140
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39277254
7RNA polymerase_Homo sapiens_hsa030202.21419253
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.15492457
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11913127
10Propanoate metabolism_Homo sapiens_hsa006401.87797331
11Basal transcription factors_Homo sapiens_hsa030221.86995776
12Asthma_Homo sapiens_hsa053101.86958497
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.72119689
14RNA degradation_Homo sapiens_hsa030181.70283753
15Steroid biosynthesis_Homo sapiens_hsa001001.68964695
16Huntingtons disease_Homo sapiens_hsa050161.68836849
17Base excision repair_Homo sapiens_hsa034101.62516571
18Fatty acid elongation_Homo sapiens_hsa000621.61713412
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59703713
20One carbon pool by folate_Homo sapiens_hsa006701.57702308
21Allograft rejection_Homo sapiens_hsa053301.54852363
22Mismatch repair_Homo sapiens_hsa034301.53174197
23Autoimmune thyroid disease_Homo sapiens_hsa053201.51869288
24Alzheimers disease_Homo sapiens_hsa050101.48697632
25Fanconi anemia pathway_Homo sapiens_hsa034601.43648516
26Phototransduction_Homo sapiens_hsa047441.42404734
27Collecting duct acid secretion_Homo sapiens_hsa049661.38720895
28Linoleic acid metabolism_Homo sapiens_hsa005911.34813347
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34339161
30Homologous recombination_Homo sapiens_hsa034401.33124541
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29812799
32Pyrimidine metabolism_Homo sapiens_hsa002401.22721530
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21323062
34Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18094285
35Type I diabetes mellitus_Homo sapiens_hsa049401.15994258
36Butanoate metabolism_Homo sapiens_hsa006501.13713534
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09933529
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09725601
39Tryptophan metabolism_Homo sapiens_hsa003801.09577483
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09095721
41Regulation of autophagy_Homo sapiens_hsa041401.07533360
42Peroxisome_Homo sapiens_hsa041461.05648030
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05490195
44Nicotine addiction_Homo sapiens_hsa050331.05323503
45Cardiac muscle contraction_Homo sapiens_hsa042601.01864303
46Spliceosome_Homo sapiens_hsa030400.99110726
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99092369
48Caffeine metabolism_Homo sapiens_hsa002320.96947970
49DNA replication_Homo sapiens_hsa030300.93224649
50RNA transport_Homo sapiens_hsa030130.92906660
51Arachidonic acid metabolism_Homo sapiens_hsa005900.92394631
52Taste transduction_Homo sapiens_hsa047420.92168899
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88883813
54Purine metabolism_Homo sapiens_hsa002300.87931286
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87615031
56Chemical carcinogenesis_Homo sapiens_hsa052040.85107622
57Glutathione metabolism_Homo sapiens_hsa004800.84311322
58Graft-versus-host disease_Homo sapiens_hsa053320.84181981
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83399607
60Nucleotide excision repair_Homo sapiens_hsa034200.82839601
61Sulfur metabolism_Homo sapiens_hsa009200.82502473
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82198552
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78908494
64Rheumatoid arthritis_Homo sapiens_hsa053230.75317621
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75164569
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74650372
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71584278
68Fat digestion and absorption_Homo sapiens_hsa049750.71262595
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68917482
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.68345155
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.67585489
72Metabolic pathways_Homo sapiens_hsa011000.64436999
73Pyruvate metabolism_Homo sapiens_hsa006200.63165786
74Primary immunodeficiency_Homo sapiens_hsa053400.63076512
75Nitrogen metabolism_Homo sapiens_hsa009100.62994687
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59188790
77Folate biosynthesis_Homo sapiens_hsa007900.59030655
78Antigen processing and presentation_Homo sapiens_hsa046120.57385020
79GABAergic synapse_Homo sapiens_hsa047270.56780266
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56363184
81Olfactory transduction_Homo sapiens_hsa047400.54958884
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52744552
83Morphine addiction_Homo sapiens_hsa050320.52035034
84Selenocompound metabolism_Homo sapiens_hsa004500.51833436
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51826150
86Ether lipid metabolism_Homo sapiens_hsa005650.50505233
87Circadian rhythm_Homo sapiens_hsa047100.50278214
88Retinol metabolism_Homo sapiens_hsa008300.49989645
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48344714
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46514730
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42986801
92beta-Alanine metabolism_Homo sapiens_hsa004100.42384362
93Ribosome_Homo sapiens_hsa030100.40904821
94Sulfur relay system_Homo sapiens_hsa041220.40667689
95Hematopoietic cell lineage_Homo sapiens_hsa046400.39105313
96Renin-angiotensin system_Homo sapiens_hsa046140.37834529
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37580114
98Oocyte meiosis_Homo sapiens_hsa041140.36591534
99Vitamin B6 metabolism_Homo sapiens_hsa007500.36262771
100Arginine and proline metabolism_Homo sapiens_hsa003300.34806088

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