TUBB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1porphyrin-containing compound metabolic process (GO:0006778)9.31801402
2heme metabolic process (GO:0042168)9.02156726
3thrombin receptor signaling pathway (GO:0070493)7.61655879
4erythrocyte maturation (GO:0043249)7.56145163
5neutrophil activation involved in immune response (GO:0002283)7.43826902
6hemoglobin metabolic process (GO:0020027)7.10596295
7response to methylmercury (GO:0051597)6.77064445
8protein neddylation (GO:0045116)6.30894021
9regulation of platelet aggregation (GO:0090330)6.12034056
10tetrapyrrole metabolic process (GO:0033013)6.03056588
11erythrocyte development (GO:0048821)5.90744836
12regulation of platelet activation (GO:0010543)5.62921851
13leukocyte migration involved in inflammatory response (GO:0002523)5.45163068
14positive regulation of mast cell activation (GO:0033005)5.18824397
15erythrocyte differentiation (GO:0030218)5.07347263
16response to lead ion (GO:0010288)4.98127721
17response to insecticide (GO:0017085)4.97374454
18adenosine receptor signaling pathway (GO:0001973)4.96075544
19myeloid cell development (GO:0061515)4.95517888
20negative regulation of norepinephrine secretion (GO:0010700)4.92660661
21pigment biosynthetic process (GO:0046148)4.89557688
22megakaryocyte development (GO:0035855)4.68473155
23negative regulation of homotypic cell-cell adhesion (GO:0034111)4.67250525
24neutrophil activation (GO:0042119)4.67201070
25G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.63631331
26positive regulation of endothelial cell differentiation (GO:0045603)4.46719374
27regulation of integrin-mediated signaling pathway (GO:2001044)4.46452782
28negative regulation of platelet activation (GO:0010544)4.32011951
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29802099
30negative regulation of viral entry into host cell (GO:0046597)4.26557608
31regulation of lipoprotein metabolic process (GO:0050746)4.22496309
32negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.20862387
33pigment metabolic process (GO:0042440)4.19237152
34plasma lipoprotein particle assembly (GO:0034377)4.15559468
35L-alpha-amino acid transmembrane transport (GO:1902475)4.13148526
36granulocyte activation (GO:0036230)4.12099771
37triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09742233
38very-low-density lipoprotein particle assembly (GO:0034379)4.09575468
39granulocyte differentiation (GO:0030851)4.08642122
40platelet degranulation (GO:0002576)4.02286040
41embryonic hemopoiesis (GO:0035162)4.00879912
42regulation of integrin activation (GO:0033623)3.99154824
43lipoxygenase pathway (GO:0019372)3.93861750
44negative regulation of thymocyte apoptotic process (GO:0070244)3.92811497
45homotypic cell-cell adhesion (GO:0034109)3.90658248
46purinergic nucleotide receptor signaling pathway (GO:0035590)3.88916437
47platelet formation (GO:0030220)3.84081652
48definitive hemopoiesis (GO:0060216)3.77100843
49purine-containing compound salvage (GO:0043101)3.76108954
50response to arsenic-containing substance (GO:0046685)3.75461643
51positive regulation of macrophage differentiation (GO:0045651)3.75007100
52negative regulation of erythrocyte differentiation (GO:0045647)3.72748332
53protein-lipid complex assembly (GO:0065005)3.72376669
54platelet activation (GO:0030168)3.70642978
55negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.65046198
56negative regulation of T-helper cell differentiation (GO:0045623)3.65046198
57regulation of homotypic cell-cell adhesion (GO:0034110)3.64180623
58positive regulation of receptor recycling (GO:0001921)3.54201025
59regulation of Golgi to plasma membrane protein transport (GO:0042996)3.54136231
60negative regulation of heart rate (GO:0010459)3.49987916
61heme transport (GO:0015886)3.48401466
62regulation of mast cell activation (GO:0033003)3.48152412
63regulation of MHC class II biosynthetic process (GO:0045346)3.45897811
64G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.45216704
65negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.44111521
66positive regulation of coagulation (GO:0050820)3.41282289
67positive regulation of Rho protein signal transduction (GO:0035025)3.37495252
68positive regulation of cAMP-mediated signaling (GO:0043950)3.35412994
69positive regulation of granulocyte differentiation (GO:0030854)3.33326124
70regulation of regulatory T cell differentiation (GO:0045589)3.31447314
71low-density lipoprotein particle remodeling (GO:0034374)3.29576622
72leukocyte degranulation (GO:0043299)3.28815693
73purinergic receptor signaling pathway (GO:0035587)3.28652076
74receptor recycling (GO:0001881)3.26262558
75regulation of erythrocyte differentiation (GO:0045646)3.25829555
76positive regulation of systemic arterial blood pressure (GO:0003084)3.23483289
77regulation of macrophage derived foam cell differentiation (GO:0010743)3.22589845
78microglial cell activation (GO:0001774)3.19920235
79regulation of mast cell degranulation (GO:0043304)3.19876596
80cofactor biosynthetic process (GO:0051188)3.18439923
81iron ion import (GO:0097286)3.17346290
82negative regulation of monooxygenase activity (GO:0032769)3.13449460
83polyamine biosynthetic process (GO:0006596)3.13342521
84regulation of viral entry into host cell (GO:0046596)3.10475354
85regulation of cytokine secretion involved in immune response (GO:0002739)3.10210395
86positive regulation of mast cell activation involved in immune response (GO:0033008)3.09215574
87positive regulation of mast cell degranulation (GO:0043306)3.09215574
88positive regulation of B cell mediated immunity (GO:0002714)3.08578717
89positive regulation of immunoglobulin mediated immune response (GO:0002891)3.08578717
90negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.08010665
91myeloid cell activation involved in immune response (GO:0002275)3.06709345
92regulation of mast cell activation involved in immune response (GO:0033006)3.06186091
93negative regulation of protein localization to cell surface (GO:2000009)3.06123883
94actin filament capping (GO:0051693)3.05889541
95termination of G-protein coupled receptor signaling pathway (GO:0038032)3.05832895
96negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.05727985
97negative regulation of heart contraction (GO:0045822)3.03927117
98negative regulation of T cell apoptotic process (GO:0070233)3.03727562
99termination of signal transduction (GO:0023021)3.03697572
100negative regulation of response to food (GO:0032096)3.01487877
101negative regulation of appetite (GO:0032099)3.01487877
102mesodermal cell differentiation (GO:0048333)3.01039559
103autophagic vacuole fusion (GO:0000046)3.00981981
104ovulation from ovarian follicle (GO:0001542)3.00067621
105water-soluble vitamin biosynthetic process (GO:0042364)2.99919513
106negative regulation of catecholamine secretion (GO:0033604)2.98588585
107regulation of memory T cell differentiation (GO:0043380)2.98138905
108fusion of sperm to egg plasma membrane (GO:0007342)2.97366168
109dendritic cell chemotaxis (GO:0002407)2.96510110
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.95870467
111positive regulation of gamma-delta T cell activation (GO:0046645)2.95598804
112N-acetylneuraminate metabolic process (GO:0006054)2.95037252
113cellular response to thyroid hormone stimulus (GO:0097067)2.94840598
114negative regulation of interleukin-17 production (GO:0032700)2.94131945
115phagocytosis, engulfment (GO:0006911)2.93828762
116negative regulation of bone mineralization (GO:0030502)2.93778263
117regulation of endothelial cell differentiation (GO:0045601)2.92111017
118regulation of blood coagulation (GO:0030193)2.91153843
119regulation of hemostasis (GO:1900046)2.91153843
120positive regulation of uterine smooth muscle contraction (GO:0070474)2.87388567
121negative regulation of neural precursor cell proliferation (GO:2000178)2.85717996
122negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82261392
123negative regulation of cell killing (GO:0031342)2.82261392
124cellular extravasation (GO:0045123)2.81531856
125regulation of T-helper 2 cell differentiation (GO:0045628)2.79705618
126negative regulation of stress fiber assembly (GO:0051497)2.79620507
127regulation of response to osmotic stress (GO:0047484)2.78789428
1283-UTR-mediated mRNA stabilization (GO:0070935)2.76408134
129plasma lipoprotein particle organization (GO:0071827)2.75658227
130regulation of T-helper 1 cell differentiation (GO:0045625)2.75216776
131positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73524824
132mitochondrial calcium ion transport (GO:0006851)2.72002690
133positive regulation of isotype switching (GO:0045830)2.71810732
134hepatocyte apoptotic process (GO:0097284)2.71709870
135bicarbonate transport (GO:0015701)2.71362491
136regulation of B cell receptor signaling pathway (GO:0050855)2.70916560
137negative regulation of nitric-oxide synthase activity (GO:0051001)2.70060830
138response to thyroid hormone (GO:0097066)2.69581011
139negative regulation of glycoprotein biosynthetic process (GO:0010561)2.68372855
140blood coagulation, intrinsic pathway (GO:0007597)2.68369763
141regulation of female receptivity (GO:0045924)2.67505558
142hemopoiesis (GO:0030097)2.65586792
143positive regulation of erythrocyte differentiation (GO:0045648)2.64229797
144positive regulation of B cell differentiation (GO:0045579)2.63314028
145protein-lipid complex subunit organization (GO:0071825)2.59610231
146hydrogen peroxide catabolic process (GO:0042744)2.59417773
147protein-cofactor linkage (GO:0018065)2.58374781
148positive regulation of histone deacetylation (GO:0031065)2.58340831
149cellular response to dexamethasone stimulus (GO:0071549)2.57018380
150cysteine metabolic process (GO:0006534)2.55660467
151one-carbon compound transport (GO:0019755)2.50592462
152lipopolysaccharide biosynthetic process (GO:0009103)2.49727105
153negative regulation of fibrinolysis (GO:0051918)2.49611190
154negative regulation of biomineral tissue development (GO:0070168)2.47076245
155regulation of uterine smooth muscle contraction (GO:0070472)2.46148342
156response to dexamethasone (GO:0071548)2.45660483
157activation of MAPKKK activity (GO:0000185)2.45290836
158regulation of norepinephrine secretion (GO:0014061)2.42220307
159immunoglobulin mediated immune response (GO:0016064)2.39636172
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.37794778
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.37794778
162negative regulation of actin filament depolymerization (GO:0030835)2.36665653
163angiogenesis involved in wound healing (GO:0060055)2.34389217
164gas transport (GO:0015669)2.32494255
165negative regulation of nitric oxide biosynthetic process (GO:0045019)2.31573231
166positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.29555583
167negative regulation of glycoprotein metabolic process (GO:1903019)2.27815490
168CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.27605791
169phospholipid efflux (GO:0033700)2.27084247
170antigen processing and presentation via MHC class Ib (GO:0002475)2.27024814
171iron ion homeostasis (GO:0055072)2.26703240
172histone H3-K36 demethylation (GO:0070544)2.22308959
173Golgi transport vesicle coating (GO:0048200)2.21801116
174COPI coating of Golgi vesicle (GO:0048205)2.21801116
175protein autoprocessing (GO:0016540)2.19014049
176platelet aggregation (GO:0070527)2.18911319
177import into cell (GO:0098657)2.16323962
178maternal placenta development (GO:0001893)2.16081372
179adrenergic receptor signaling pathway (GO:0071875)2.15543005
180lipopolysaccharide metabolic process (GO:0008653)2.13548635
181purine nucleotide salvage (GO:0032261)2.13291173
182positive regulation of blood coagulation (GO:0030194)2.12272461
183positive regulation of hemostasis (GO:1900048)2.12272461
184positive regulation of chemokine biosynthetic process (GO:0045080)2.09691844
185protoporphyrinogen IX metabolic process (GO:0046501)18.0340418
186protoporphyrinogen IX biosynthetic process (GO:0006782)16.9949842
187porphyrin-containing compound biosynthetic process (GO:0006779)11.6048169
188heme biosynthetic process (GO:0006783)11.2706479
189tetrapyrrole biosynthetic process (GO:0033014)10.2491046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human6.00919254
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.89178225
3E2F7_22180533_ChIP-Seq_HELA_Human4.82244980
4* GATA1_19941826_ChIP-Seq_K562_Human4.20602752
5SCL_19346495_ChIP-Seq_HPC-7_Human4.03172860
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93050204
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.83976853
8TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse3.69484807
9* GATA1_19941827_ChIP-Seq_MEL_Mouse3.37939065
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.07057197
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.97871135
12KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.70520469
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.69183640
14* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.64075503
15* GATA2_19941826_ChIP-Seq_K562_Human2.57234608
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.52342104
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.13747806
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.12114811
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.02139066
20MYC_22102868_ChIP-Seq_BL_Human2.00960301
21RUNX_20019798_ChIP-Seq_JUKART_Human2.00698942
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00270393
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.00023775
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.96984770
25VDR_21846776_ChIP-Seq_THP-1_Human1.95974526
26BP1_19119308_ChIP-ChIP_Hs578T_Human1.88256355
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84009098
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82135775
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80154788
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.79626199
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.78603293
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.71216946
33* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.67412754
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66183416
35GATA1_19941827_ChIP-Seq_MEL86_Mouse1.65365218
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64296079
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.64035643
38* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.63670305
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.62268895
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61666769
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.60627340
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59590770
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54594470
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53405372
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52588013
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52245388
47ZNF263_19887448_ChIP-Seq_K562_Human1.51280159
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50632156
49MAF_26560356_Chip-Seq_TH1_Human1.50300885
50HTT_18923047_ChIP-ChIP_STHdh_Human1.47595281
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42903194
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.42891333
53RUNX1_22412390_ChIP-Seq_EML_Mouse1.42777819
54EZH2_22144423_ChIP-Seq_EOC_Human1.42690853
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41218028
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41155232
57TFEB_21752829_ChIP-Seq_HELA_Human1.40887238
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40561980
59* NCOR1_26117541_ChIP-Seq_K562_Human1.40405643
60GBX2_23144817_ChIP-Seq_PC3_Human1.39239787
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.38252433
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38124618
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37611815
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36873724
65BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36670737
66UTX_26944678_Chip-Seq_JUKART_Human1.32525574
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31668694
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30196827
69TCF7_22412390_ChIP-Seq_EML_Mouse1.29241330
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29021625
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28964484
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28808326
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28627276
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27976377
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27230645
76* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27031795
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26600568
78VDR_24763502_ChIP-Seq_THP-1_Human1.26502968
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25473891
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24767609
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23744791
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.21698459
83* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19002229
84STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18888502
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.17645023
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16497529
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16303162
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13835509
89SPI1_23127762_ChIP-Seq_K562_Human1.13050980
90TAF15_26573619_Chip-Seq_HEK293_Human1.12014810
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.11938951
92* GATA3_27048872_Chip-Seq_THYMUS_Human1.11861519
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.11667075
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.10651764
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.09604206
96PU_27001747_Chip-Seq_BMDM_Mouse1.08413695
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.07862686
98CLOCK_20551151_ChIP-Seq_293T_Human1.07467217
99MYC_18555785_ChIP-Seq_MESCs_Mouse1.07446989
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07285566
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06291932
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.05746840
103NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05027713
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05027713
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.04527539
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03190460
107MYB_26560356_Chip-Seq_TH2_Human1.02034612
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01980471
109ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01890881
110SPI1_23547873_ChIP-Seq_NB4_Human1.01732372
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01393641
112CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99987020
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97942617
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.96205122
115KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96057654
116CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95310392
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.95047450
118SPI1_20517297_ChIP-Seq_HL60_Human0.94579383
119VDR_24787735_ChIP-Seq_THP-1_Human0.93164082
120MAF_26560356_Chip-Seq_TH2_Human0.92877351
121IRF8_27001747_Chip-Seq_BMDM_Mouse0.92432595
122VDR_23849224_ChIP-Seq_CD4+_Human0.91850141
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91828214
124BCOR_27268052_Chip-Seq_Bcells_Human0.91603971
125EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91115722
126* GATA3_26560356_Chip-Seq_TH2_Human0.90949308
127TCF4_18268006_ChIP-ChIP_LS174T_Human0.90258749
128CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90068918
129POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88644252
130MYB_26560356_Chip-Seq_TH1_Human0.88478621
131E2F1_21310950_ChIP-Seq_MCF-7_Human0.88051826
132EST1_17652178_ChIP-ChIP_JURKAT_Human0.87314306
133NELFA_20434984_ChIP-Seq_ESCs_Mouse0.86560815
134CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86356571
135KDM2B_26808549_Chip-Seq_DND41_Human0.84950789
136FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84692030
137XRN2_22483619_ChIP-Seq_HELA_Human0.84404814
138FOXP3_21729870_ChIP-Seq_TREG_Human0.83847154
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83796672
140MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83685963
141SMRT_27268052_Chip-Seq_Bcells_Human0.82377516
142LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81911539
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80465835
144GF1_26923725_Chip-Seq_HPCs_Mouse0.77256972
145CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75000850
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74964288
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74639439
148CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.74601847
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74494443
150RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.74437027
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.71945541
152EZH2_27294783_Chip-Seq_NPCs_Mouse0.71776913
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71734459
154JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71547359
155TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71316546
156OCT1_27270436_Chip-Seq_PROSTATE_Human0.70762807
157AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.70098662
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69390565
159OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68565433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level9.06441825
2MP0003656_abnormal_erythrocyte_physiolo8.97285180
3MP0008004_abnormal_stomach_pH5.34891690
4MP0005083_abnormal_biliary_tract2.79292481
5MP0000685_abnormal_immune_system2.26212984
6* MP0005464_abnormal_platelet_physiology2.24422940
7MP0006054_spinal_hemorrhage2.24292939
8MP0004084_abnormal_cardiac_muscle2.22140596
9MP0002877_abnormal_melanocyte_morpholog2.15667015
10MP0003300_gastrointestinal_ulcer2.13122718
11MP0003828_pulmonary_edema2.05301587
12MP0001545_abnormal_hematopoietic_system1.97357840
13MP0005397_hematopoietic_system_phenotyp1.97357840
14MP0005636_abnormal_mineral_homeostasis1.95110181
15MP0003111_abnormal_nucleus_morphology1.83268430
16MP0010368_abnormal_lymphatic_system1.81265749
17MP0002148_abnormal_hypersensitivity_rea1.76284142
18MP0001851_eye_inflammation1.74888807
19MP0000230_abnormal_systemic_arterial1.72016407
20MP0003191_abnormal_cellular_cholesterol1.70541159
21MP0005671_abnormal_response_to1.70409393
22MP0004510_myositis1.65105896
23MP0002138_abnormal_hepatobiliary_system1.61200811
24MP0002736_abnormal_nociception_after1.59769560
25MP0004130_abnormal_muscle_cell1.58744012
26* MP0002398_abnormal_bone_marrow1.53778720
27MP0002139_abnormal_hepatobiliary_system1.53425659
28MP0002396_abnormal_hematopoietic_system1.52484520
29MP0003638_abnormal_response/metabolism_1.51946062
30MP0004036_abnormal_muscle_relaxation1.51020963
31MP0005084_abnormal_gallbladder_morpholo1.47769678
32MP0001533_abnormal_skeleton_physiology1.47709109
33MP0000689_abnormal_spleen_morphology1.46548910
34MP0002722_abnormal_immune_system1.43873730
35MP0003303_peritoneal_inflammation1.43498443
36MP0006036_abnormal_mitochondrial_physio1.41714073
37MP0000858_altered_metastatic_potential1.38193004
38MP0001835_abnormal_antigen_presentation1.37897916
39MP0002132_abnormal_respiratory_system1.37640244
40MP0000249_abnormal_blood_vessel1.36932007
41MP0009785_altered_susceptibility_to1.34680090
42MP0001663_abnormal_digestive_system1.31316855
43MP0003436_decreased_susceptibility_to1.30152307
44MP0004808_abnormal_hematopoietic_stem1.28337775
45* MP0002429_abnormal_blood_cell1.26333619
46MP0009765_abnormal_xenobiotic_induced1.25624360
47MP0000465_gastrointestinal_hemorrhage1.24697785
48MP0005310_abnormal_salivary_gland1.20410455
49MP0005025_abnormal_response_to1.20384983
50MP0000609_abnormal_liver_physiology1.18394372
51MP0003186_abnormal_redox_activity1.16342415
52MP0005409_darkened_coat_color1.12875603
53MP0005000_abnormal_immune_tolerance1.12365957
54MP0004883_abnormal_blood_vessel1.09871083
55MP0001790_abnormal_immune_system1.09364445
56MP0005387_immune_system_phenotype1.09364445
57MP0010329_abnormal_lipoprotein_level1.09350886
58MP0000015_abnormal_ear_pigmentation1.09314634
59MP0003879_abnormal_hair_cell1.08903756
60MP0005085_abnormal_gallbladder_physiolo1.08757641
61MP0003195_calcinosis1.07191778
62MP0000490_abnormal_crypts_of1.06856094
63MP0009763_increased_sensitivity_to1.06678802
64MP0002998_abnormal_bone_remodeling1.06310100
65MP0002419_abnormal_innate_immunity1.04658534
66MP0004484_altered_response_of1.04224414
67MP0009333_abnormal_splenocyte_physiolog1.03856112
68MP0005410_abnormal_fertilization1.03758876
69MP0003724_increased_susceptibility_to1.03126943
70MP0008260_abnormal_autophagy1.01428643
71MP0000598_abnormal_liver_morphology1.00264529
72MP0009697_abnormal_copulation1.00087987
73MP0008874_decreased_physiological_sensi0.98492077
74MP0010155_abnormal_intestine_physiology0.98262928
75MP0003077_abnormal_cell_cycle0.97926765
76MP0003566_abnormal_cell_adhesion0.97899911
77MP0001879_abnormal_lymphatic_vessel0.97862694
78MP0005167_abnormal_blood-brain_barrier0.97734452
79MP0009931_abnormal_skin_appearance0.96488013
80MP0003866_abnormal_defecation0.95988394
81MP0001800_abnormal_humoral_immune0.95950348
82MP0009840_abnormal_foam_cell0.94751423
83MP0002452_abnormal_antigen_presenting0.94402582
84MP0008469_abnormal_protein_level0.94176290
85MP0002420_abnormal_adaptive_immunity0.92904859
86MP0003183_abnormal_peptide_metabolism0.92593820
87MP0008775_abnormal_heart_ventricle0.92459250
88MP0001968_abnormal_touch/_nociception0.92026616
89MP0004947_skin_inflammation0.91280702
90MP0001819_abnormal_immune_cell0.90901781
91MP0000716_abnormal_immune_system0.90860540
92MP0002405_respiratory_system_inflammati0.89000746
93MP0001845_abnormal_inflammatory_respons0.88982725
94MP0002723_abnormal_immune_serum0.88891689
95MP0002733_abnormal_thermal_nociception0.88585492
96MP0005023_abnormal_wound_healing0.87896188
97MP0005058_abnormal_lysosome_morphology0.87611980
98MP0000343_altered_response_to0.86073326
99MP0002693_abnormal_pancreas_physiology0.85399025
100MP0008872_abnormal_physiological_respon0.85288208
101MP0009643_abnormal_urine_homeostasis0.83163636
102MP0003091_abnormal_cell_migration0.83066572
103MP0005174_abnormal_tail_pigmentation0.82159826
104* MP0009642_abnormal_blood_homeostasis0.81837545
105MP0004381_abnormal_hair_follicle0.79736294
106MP0005360_urolithiasis0.79528427
107MP0003448_altered_tumor_morphology0.79437961
108MP0003172_abnormal_lysosome_physiology0.78958840
109MP0000313_abnormal_cell_death0.78685781
110MP0001765_abnormal_ion_homeostasis0.78666335
111MP0010094_abnormal_chromosome_stability0.78559952
112MP0005381_digestive/alimentary_phenotyp0.77392817
113MP0003693_abnormal_embryo_hatching0.76751826
114MP0009764_decreased_sensitivity_to0.76741825
115MP0000703_abnormal_thymus_morphology0.75604103
116MP0003453_abnormal_keratinocyte_physiol0.75526281
117MP0005165_increased_susceptibility_to0.74749173
118MP0010307_abnormal_tumor_latency0.74163922
119MP0005646_abnormal_pituitary_gland0.74116262
120MP0001873_stomach_inflammation0.73876163
121MP0001853_heart_inflammation0.73564746
122MP0005595_abnormal_vascular_smooth0.72858625
123MP0005365_abnormal_bile_salt0.72382381
124MP0005319_abnormal_enzyme/_coenzyme0.71523026
125MP0001764_abnormal_homeostasis0.69921143
126MP0002972_abnormal_cardiac_muscle0.69698161
127MP0001664_abnormal_digestion0.69555276
128MP0005385_cardiovascular_system_phenoty0.68732047
129MP0001544_abnormal_cardiovascular_syste0.68732047
130MP0002332_abnormal_exercise_endurance0.67770031
131MP0003806_abnormal_nucleotide_metabolis0.67642100
132MP0008770_decreased_survivor_rate0.67484825
133MP0003252_abnormal_bile_duct0.66952730
134MP0002078_abnormal_glucose_homeostasis0.66590820
135MP0000749_muscle_degeneration0.65259196
136MP0004957_abnormal_blastocyst_morpholog0.65168030
137MP0005666_abnormal_adipose_tissue0.65083401
138MP0003763_abnormal_thymus_physiology0.64751871
139MP0002128_abnormal_blood_circulation0.64308642
140MP0002019_abnormal_tumor_incidence0.64077395
141MP0005535_abnormal_body_temperature0.63964606
142MP0005501_abnormal_skin_physiology0.63175304
143MP0003075_altered_response_to0.62559817
144MP0001944_abnormal_pancreas_morphology0.61176182
145MP0003123_paternal_imprinting0.60827873
146MP0002837_dystrophic_cardiac_calcinosis0.60182746

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)8.68697696
2Acanthocytosis (HP:0001927)8.40745605
3Reticulocytosis (HP:0001923)6.96409292
4Cholelithiasis (HP:0001081)5.75291396
5Polycythemia (HP:0001901)5.35601105
6Abnormal gallbladder morphology (HP:0012437)5.34204527
7Paralysis (HP:0003470)5.26300755
8Diaphragmatic weakness (HP:0009113)5.11921688
9Hyperbilirubinemia (HP:0002904)4.96351478
10Hyperlipoproteinemia (HP:0010980)4.91300605
11Microcytic anemia (HP:0001935)4.78737698
12Osteomalacia (HP:0002749)4.70673243
13Abnormality of reticulocytes (HP:0004312)4.54754275
14Hypochromic anemia (HP:0001931)4.47290186
15Insomnia (HP:0100785)4.21456713
16Abnormal gallbladder physiology (HP:0012438)4.16406831
17Cholecystitis (HP:0001082)4.16406831
18Prolonged bleeding time (HP:0003010)4.01100146
19Petechiae (HP:0000967)3.79786783
20Abnormality of the gallbladder (HP:0005264)3.71058558
21Bruising susceptibility (HP:0000978)3.59169710
22Dyschromatopsia (HP:0007641)3.57952489
23Nonimmune hydrops fetalis (HP:0001790)3.54042323
24Epistaxis (HP:0000421)3.44802135
25Abnormal platelet function (HP:0011869)3.36395732
26Impaired platelet aggregation (HP:0003540)3.36395732
27Cutaneous photosensitivity (HP:0000992)3.16575080
28Abnormality of the vasculature of the conjunctiva (HP:0008054)3.13134615
29Purpura (HP:0000979)3.11368923
30Amaurosis fugax (HP:0100576)3.08321223
31Menorrhagia (HP:0000132)3.07319925
32Abnormal pupillary function (HP:0007686)3.05863640
33Ileus (HP:0002595)3.03776672
34Abnormality of macrophages (HP:0004311)3.01931101
35Hepatocellular carcinoma (HP:0001402)3.01687556
36Increased density of long bones (HP:0006392)2.95612814
37Stomatitis (HP:0010280)2.82397464
38Nausea (HP:0002018)2.81897992
39Spontaneous hematomas (HP:0007420)2.73386822
40Abnormality of iron homeostasis (HP:0011031)2.70312423
41Increased serum ferritin (HP:0003281)2.69612434
42Urticaria (HP:0001025)2.68948107
43Eczematoid dermatitis (HP:0000976)2.57424610
44Cerebral palsy (HP:0100021)2.53280900
45Arterial thrombosis (HP:0004420)2.51117649
46Gingival bleeding (HP:0000225)2.47481060
47Joint swelling (HP:0001386)2.41547058
48Abnormality of transition element cation homeostasis (HP:0011030)2.40051753
49Abnormality of lateral ventricle (HP:0030047)2.38998754
50Hepatosplenomegaly (HP:0001433)2.32866050
51Abnormal platelet volume (HP:0011876)2.32609339
52Chronic obstructive pulmonary disease (HP:0006510)2.31717232
53Obstructive lung disease (HP:0006536)2.31717232
54Abnormality of the nasal mucosa (HP:0000433)2.31064761
55Generalized hyperpigmentation (HP:0007440)2.29085955
56Encephalitis (HP:0002383)2.28695244
57Pancreatic islet-cell hyperplasia (HP:0004510)2.27431357
58Abnormal auditory evoked potentials (HP:0006958)2.27312155
59Increased mean platelet volume (HP:0011877)2.26374704
60Tinnitus (HP:0000360)2.25907514
61Increased IgM level (HP:0003496)2.25480796
62Recurrent bacterial skin infections (HP:0005406)2.25095080
63Autoimmune thrombocytopenia (HP:0001973)2.17701611
64Joint hemorrhage (HP:0005261)2.14571396
65Hyponatremia (HP:0002902)2.14456274
66Papillary thyroid carcinoma (HP:0002895)2.14217179
67Thrombophlebitis (HP:0004418)2.11798694
68Chest pain (HP:0100749)2.09172776
69Episodic fever (HP:0001954)2.06338693
70Hypoglycemic seizures (HP:0002173)2.05064201
71Tetraparesis (HP:0002273)2.04040561
72Abnormality of the common coagulation pathway (HP:0010990)2.03410042
73Upper limb muscle weakness (HP:0003484)2.02464444
74Abnormal number of erythroid precursors (HP:0012131)2.02081282
75Vertebral compression fractures (HP:0002953)2.01013582
76Deep venous thrombosis (HP:0002625)2.00449930
77Abnormality of the heme biosynthetic pathway (HP:0010472)12.6593769
78Poikilocytosis (HP:0004447)10.3108752
79Autoimmune hemolytic anemia (HP:0001890)1.97763362
80Decreased central vision (HP:0007663)1.96252322
81Hypoglycemic coma (HP:0001325)1.95648955
82Pathologic fracture (HP:0002756)1.93308591
83Abnormality of cells of the erythroid lineage (HP:0012130)1.93081878
84Hypertensive crisis (HP:0100735)1.91887053
85Short middle phalanx of the 5th finger (HP:0004220)1.90524877
86Broad palm (HP:0001169)1.87946840
87Aplastic anemia (HP:0001915)1.87730827
88Myocardial infarction (HP:0001658)1.83562093
89Vertigo (HP:0002321)1.82146429
90Depression (HP:0000716)1.78033608
91Increased neuronal autofluorescent lipopigment (HP:0002074)1.77278839
92Thrombocytosis (HP:0001894)1.76575657
93Abnormality of the pancreatic islet cells (HP:0006476)1.76068715
94Abnormality of endocrine pancreas physiology (HP:0012093)1.76068715
95Abnormality of the intrinsic pathway (HP:0010989)1.75879360
96Macrocytic anemia (HP:0001972)1.75438472
97Abnormality of sodium homeostasis (HP:0010931)1.74658246
98Recurrent abscess formation (HP:0002722)1.74644525
99Nasal polyposis (HP:0100582)1.74332527
100Increased cerebral lipofuscin (HP:0011813)1.74073807
101Lower limb hyperreflexia (HP:0002395)1.74021003
102Abnormality of B cell number (HP:0010975)1.73912473
103B lymphocytopenia (HP:0010976)1.73912473
104Leukocytosis (HP:0001974)1.73678119
105Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.72756809
106Elevated erythrocyte sedimentation rate (HP:0003565)1.72130861
107Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.69559831
108T lymphocytopenia (HP:0005403)1.68483466
109Progressive microcephaly (HP:0000253)1.68472937
110Interstitial pulmonary disease (HP:0006530)1.68437118
111Ventricular fibrillation (HP:0001663)1.68398152
112Inflammation of the large intestine (HP:0002037)1.65950481
113Hyperthyroidism (HP:0000836)1.64389555
114Transitional cell carcinoma of the bladder (HP:0006740)1.62670303
115Hematochezia (HP:0002573)1.62378884
116Optic neuritis (HP:0100653)1.62213521
117Retrobulbar optic neuritis (HP:0100654)1.62213521
118Muscle fibrillation (HP:0010546)1.62207723
119Leiomyosarcoma (HP:0100243)1.62051233
120Uterine leiomyosarcoma (HP:0002891)1.62051233
121Testicular neoplasm (HP:0010788)1.60732087
122Conjunctival telangiectasia (HP:0000524)1.59516095
123Basal ganglia calcification (HP:0002135)1.59279763
124Abnormality of T cell number (HP:0011839)1.58620368
125Anorexia (HP:0002039)1.58037583
126Diplopia (HP:0000651)1.57825684
127Abnormality of binocular vision (HP:0011514)1.57825684
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.57652080
129Male infertility (HP:0003251)1.57463374
130Renal tubular acidosis (HP:0001947)1.57086803
131Onycholysis (HP:0001806)1.54770893
132Vasculitis (HP:0002633)1.54595857
133Xanthomatosis (HP:0000991)1.52246281
134Confusion (HP:0001289)1.52146649
135Myositis (HP:0100614)1.52013071
136Distal lower limb amyotrophy (HP:0008944)1.51866287
137Generalized aminoaciduria (HP:0002909)1.51244919
138Bladder carcinoma (HP:0002862)1.50886638
139Bladder neoplasm (HP:0009725)1.50886638
140Tongue fasciculations (HP:0001308)1.50586911
141Gastrointestinal inflammation (HP:0004386)1.49431312
142Pustule (HP:0200039)1.49194402
143Dysostosis multiplex (HP:0000943)1.48688317
144Hyperinsulinemic hypoglycemia (HP:0000825)1.48638046
145Metabolic acidosis (HP:0001942)1.47726468
146Orchitis (HP:0100796)1.47062153
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.46956353
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.46785011
149Abnormality of the prostate (HP:0008775)1.46609278
150Dysautonomia (HP:0002459)1.46182741
151Symptomatic seizures (HP:0011145)1.46053640
152Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.45927367
153Spontaneous abortion (HP:0005268)1.45806973
154Recurrent fungal infections (HP:0002841)1.44485803
155Gastrointestinal infarctions (HP:0005244)1.43087610
156Mucosal telangiectasiae (HP:0100579)1.43024515
157Cerebral ischemia (HP:0002637)1.41964562
158Neoplasm of the liver (HP:0002896)1.41582949
159IgM deficiency (HP:0002850)1.41478928
160Granulocytopenia (HP:0001913)1.41392421
161Hypertriglyceridemia (HP:0002155)1.41228576
162Thyroid-stimulating hormone excess (HP:0002925)1.40347371
163Global brain atrophy (HP:0002283)1.40319713
164Splenomegaly (HP:0001744)1.40278493
165Meningitis (HP:0001287)1.39966365
166Pulmonary embolism (HP:0002204)1.39668490
167Eosinophilia (HP:0001880)1.38376802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.33731939
2EIF2AK15.66454693
3MST43.83745974
4MYLK2.92122473
5KDR2.84395302
6TGFBR22.62445201
7TIE12.57043318
8MAP4K12.55843794
9BRSK22.54988365
10TRIB32.38964677
11PIK3CG2.34979653
12MAP3K102.31727497
13BRSK12.21346122
14BMPR22.07901162
15FGR2.04512880
16EEF2K2.02237764
17TAOK31.95655077
18GRK51.92393662
19STK101.91241381
20HCK1.77856267
21TBK11.74124002
22SYK1.68364448
23PIM11.67792045
24FES1.66209949
25STK41.65691145
26JAK31.63861496
27MAPKAPK31.57626270
28PKN21.55418655
29FLT31.44193328
30STK241.39376011
31TYK21.36377347
32EPHB11.34739004
33LRRK21.34418371
34IKBKE1.26566085
35JAK21.25295032
36CDK91.23252386
37TNK21.22241006
38BUB11.20498141
39ITK1.17274643
40HIPK21.16496514
41TRPM71.15979178
42ZAP701.13163326
43IRAK11.09914855
44GRK61.09618453
45CDC71.08349353
46MAPK111.07498842
47KIT1.07375460
48LYN1.05852564
49PTK61.05025595
50RPS6KA51.04536985
51IKBKB1.02292327
52SIK31.01137660
53ADRBK20.97918315
54ERN10.97422883
55PRKG20.97248779
56MAPKAPK50.94964588
57ACVR1B0.93821449
58FGFR40.93708911
59TNIK0.93375486
60PAK10.91673429
61CDK60.90936804
62YES10.89682928
63TLK10.89055735
64MAP3K50.88958437
65PLK20.87515014
66PINK10.86747598
67MARK30.86702509
68CDK120.85121013
69PNCK0.84984934
70JAK10.84906008
71NEK20.84866649
72CAMKK20.84847957
73MAP3K30.84656108
74MATK0.83649978
75VRK10.83339409
76MUSK0.83021091
77STK30.82823707
78BTK0.82132758
79MAP3K80.82090101
80CHUK0.82058216
81EPHA30.81453893
82IRAK40.80762214
83CHEK20.79649822
84LMTK20.79401492
85MAP2K30.77728101
86TXK0.77263008
87RPS6KB20.74954515
88TAOK20.71908913
89MAP3K110.71278041
90RPS6KA40.71140864
91NME20.70865750
92CLK10.70323519
93DYRK30.69872740
94MAPKAPK20.69717831
95ADRBK10.68842774
96IRAK20.67412675
97SGK20.67343849
98PASK0.63318996
99PDGFRB0.61103395
100PRKD10.60451601
101AURKB0.59461879
102MELK0.59353790
103MAPK120.57902686
104MAP2K20.57805682
105DAPK30.57787500
106SGK30.57436409
107AURKA0.55720465
108LCK0.55167336
109FYN0.54976673
110SCYL20.54853103
111CDK40.54167981
112NLK0.53298101
113TRIM280.53224404
114TEC0.52618805
115PRKACG0.51565482
116ALK0.51339639
117DYRK1B0.51124795
118PIM20.50971956
119ERBB20.49867583
120FER0.49672123
121PDK10.49516671
122BLK0.49511108
123MAP2K10.49462264
124DAPK10.48886525
125INSRR0.47648932
126PTK2B0.47309080
127MAPK150.47279743
128PDPK10.46793722
129BMX0.45613727
130CSF1R0.45185294
131DAPK20.44571083
132MAP3K10.43772471
133MAP3K70.42261160
134WEE10.42009680
135ILK0.40291835
136CDC42BPA0.39735394
137CSK0.39435119
138RET0.39343868
139PRKCQ0.38984251
140NEK90.38082016
141TAOK10.37692965
142PRKG10.34823256
143PAK30.34046860
144CAMK1G0.32754200
145PRKCD0.31343742
146IRAK30.31009159
147MAP3K20.29927616
148PKN10.27634934
149ARAF0.26188586
150PRKCB0.25930366
151TESK20.25727745
152RAF10.24533539
153MINK10.24356501
154SRC0.23083958
155MARK20.22781501

Predicted pathways (KEGG)

RankGene SetZ-score
1Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008608.66023138
2Vitamin B6 metabolism_Homo sapiens_hsa007505.63087437
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.32348641
4Systemic lupus erythematosus_Homo sapiens_hsa053223.17818258
5ABC transporters_Homo sapiens_hsa020102.51833011
6* Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.22234595
7Hematopoietic cell lineage_Homo sapiens_hsa046402.05490873
8Selenocompound metabolism_Homo sapiens_hsa004502.03148651
9Malaria_Homo sapiens_hsa051441.92059928
10Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.88568303
11ECM-receptor interaction_Homo sapiens_hsa045121.85383251
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79624133
13Alcoholism_Homo sapiens_hsa050341.67797114
14Arachidonic acid metabolism_Homo sapiens_hsa005901.66157149
15Complement and coagulation cascades_Homo sapiens_hsa046101.61301805
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53653019
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52766283
18T cell receptor signaling pathway_Homo sapiens_hsa046601.51296081
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50246840
20DNA replication_Homo sapiens_hsa030301.45885580
21Leishmaniasis_Homo sapiens_hsa051401.45438005
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.41580790
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.37038918
24Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.36581818
25Cell cycle_Homo sapiens_hsa041101.30261067
26Serotonergic synapse_Homo sapiens_hsa047261.30077267
27Platelet activation_Homo sapiens_hsa046111.29622851
28Shigellosis_Homo sapiens_hsa051311.28520023
29Endocytosis_Homo sapiens_hsa041441.27906986
30Caffeine metabolism_Homo sapiens_hsa002321.24961818
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23505563
32Phospholipase D signaling pathway_Homo sapiens_hsa040721.21467320
33Sulfur relay system_Homo sapiens_hsa041221.20639851
34Staphylococcus aureus infection_Homo sapiens_hsa051501.17089526
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14323489
36Viral carcinogenesis_Homo sapiens_hsa052031.13194243
37* Gap junction_Homo sapiens_hsa045401.07804842
38Primary immunodeficiency_Homo sapiens_hsa053401.07394365
39Pancreatic secretion_Homo sapiens_hsa049721.07222953
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.05955106
41Apoptosis_Homo sapiens_hsa042101.05827872
42Long-term depression_Homo sapiens_hsa047301.04681752
43B cell receptor signaling pathway_Homo sapiens_hsa046621.00768859
44Legionellosis_Homo sapiens_hsa051340.98409560
45Adipocytokine signaling pathway_Homo sapiens_hsa049200.98340809
46Ribosome_Homo sapiens_hsa030100.97916547
47Choline metabolism in cancer_Homo sapiens_hsa052310.97306273
48Collecting duct acid secretion_Homo sapiens_hsa049660.95097750
49Rap1 signaling pathway_Homo sapiens_hsa040150.92848050
50Glycerolipid metabolism_Homo sapiens_hsa005610.91787325
51Measles_Homo sapiens_hsa051620.91552973
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91159024
53One carbon pool by folate_Homo sapiens_hsa006700.89542946
54Insulin resistance_Homo sapiens_hsa049310.89479383
55Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88886120
56Chronic myeloid leukemia_Homo sapiens_hsa052200.88662269
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88491916
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88324876
59Endometrial cancer_Homo sapiens_hsa052130.87965454
60Focal adhesion_Homo sapiens_hsa045100.87935760
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87780130
62Herpes simplex infection_Homo sapiens_hsa051680.87758028
63Base excision repair_Homo sapiens_hsa034100.87126947
64Bladder cancer_Homo sapiens_hsa052190.86691160
65Graft-versus-host disease_Homo sapiens_hsa053320.85633427
66Antigen processing and presentation_Homo sapiens_hsa046120.85196718
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84468952
68Nitrogen metabolism_Homo sapiens_hsa009100.82661992
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.82092459
70Mismatch repair_Homo sapiens_hsa034300.82086729
71Acute myeloid leukemia_Homo sapiens_hsa052210.79402558
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78717229
73VEGF signaling pathway_Homo sapiens_hsa043700.78510488
74Osteoclast differentiation_Homo sapiens_hsa043800.77890521
75* Phagosome_Homo sapiens_hsa041450.75996536
76Other glycan degradation_Homo sapiens_hsa005110.74602700
77Renal cell carcinoma_Homo sapiens_hsa052110.73986469
78Fatty acid degradation_Homo sapiens_hsa000710.73802294
79Pentose phosphate pathway_Homo sapiens_hsa000300.73741620
80p53 signaling pathway_Homo sapiens_hsa041150.70606927
81Olfactory transduction_Homo sapiens_hsa047400.69950271
82Allograft rejection_Homo sapiens_hsa053300.69249969
83Amoebiasis_Homo sapiens_hsa051460.68896812
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.67445435
85Hepatitis B_Homo sapiens_hsa051610.67354589
86Type II diabetes mellitus_Homo sapiens_hsa049300.66302000
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65678398
88Autoimmune thyroid disease_Homo sapiens_hsa053200.65155077
89Glioma_Homo sapiens_hsa052140.64971990
90Non-small cell lung cancer_Homo sapiens_hsa052230.64872844
91Ras signaling pathway_Homo sapiens_hsa040140.63902141
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.63481026
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.62654798
94Morphine addiction_Homo sapiens_hsa050320.62600966
95Circadian entrainment_Homo sapiens_hsa047130.62283886
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61426781
97Renin-angiotensin system_Homo sapiens_hsa046140.60650473
98Homologous recombination_Homo sapiens_hsa034400.58925138
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58794691
100Salmonella infection_Homo sapiens_hsa051320.57584911
101Pancreatic cancer_Homo sapiens_hsa052120.57436931
102AMPK signaling pathway_Homo sapiens_hsa041520.56865039
103Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55964706
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54770159
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54004981
106Linoleic acid metabolism_Homo sapiens_hsa005910.53985159
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52814453
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51529087
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51159969
110Tryptophan metabolism_Homo sapiens_hsa003800.50980140
111Fructose and mannose metabolism_Homo sapiens_hsa000510.50728808
112Cholinergic synapse_Homo sapiens_hsa047250.50600170
113Thyroid cancer_Homo sapiens_hsa052160.49478209
114Pyruvate metabolism_Homo sapiens_hsa006200.49158277
115Renin secretion_Homo sapiens_hsa049240.48190190
116Insulin signaling pathway_Homo sapiens_hsa049100.47654393
117Lysosome_Homo sapiens_hsa041420.46796100
118Adherens junction_Homo sapiens_hsa045200.46526192
119Viral myocarditis_Homo sapiens_hsa054160.46366522
120Asthma_Homo sapiens_hsa053100.46143604
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46143313
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.45720797
123Calcium signaling pathway_Homo sapiens_hsa040200.45447716
124Glutathione metabolism_Homo sapiens_hsa004800.45253775
125Gastric acid secretion_Homo sapiens_hsa049710.44247713
126Influenza A_Homo sapiens_hsa051640.43993948
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43895293
128FoxO signaling pathway_Homo sapiens_hsa040680.43495887
129Fat digestion and absorption_Homo sapiens_hsa049750.43400442
130Dilated cardiomyopathy_Homo sapiens_hsa054140.43291178
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.43231592
132Lysine degradation_Homo sapiens_hsa003100.42602315
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42205270
134Oxytocin signaling pathway_Homo sapiens_hsa049210.42091297
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41947128
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41004540
137Sulfur metabolism_Homo sapiens_hsa009200.40635181
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38764352
139Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38267559
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37659424
141Hepatitis C_Homo sapiens_hsa051600.36430348
142Toxoplasmosis_Homo sapiens_hsa051450.35196863
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34445089
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.33972080
145Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32879131
146Chemokine signaling pathway_Homo sapiens_hsa040620.32543848
147Biosynthesis of amino acids_Homo sapiens_hsa012300.32434646
148Folate biosynthesis_Homo sapiens_hsa007900.32303574
149Glucagon signaling pathway_Homo sapiens_hsa049220.32260971
150HTLV-I infection_Homo sapiens_hsa051660.31144090
151Carbon metabolism_Homo sapiens_hsa012000.30543400
152PPAR signaling pathway_Homo sapiens_hsa033200.29469250
153Small cell lung cancer_Homo sapiens_hsa052220.27843273
154Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.27265477
155Bile secretion_Homo sapiens_hsa049760.27251400
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27131035
157Primary bile acid biosynthesis_Homo sapiens_hsa001200.26627646
158Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26254568
159Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25653187
160Histidine metabolism_Homo sapiens_hsa003400.25461285
161Protein export_Homo sapiens_hsa030600.24659627
162Tuberculosis_Homo sapiens_hsa051520.24588455
163Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.24136200
164African trypanosomiasis_Homo sapiens_hsa051430.21972155

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