TUBB2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.58988265
2neuron cell-cell adhesion (GO:0007158)5.54279613
3establishment of mitochondrion localization (GO:0051654)5.49764626
4synaptic vesicle exocytosis (GO:0016079)5.41427632
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.23242183
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18537186
7protein localization to synapse (GO:0035418)5.08164461
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72028995
9regulation of glutamate receptor signaling pathway (GO:1900449)4.64339634
10regulation of synaptic vesicle exocytosis (GO:2000300)4.50952324
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.50824029
12glutamate secretion (GO:0014047)4.47232329
13neuron recognition (GO:0008038)4.44119166
14pyrimidine nucleobase catabolic process (GO:0006208)4.37276235
15layer formation in cerebral cortex (GO:0021819)4.35061545
16negative regulation of microtubule polymerization (GO:0031115)4.33820245
17locomotory exploration behavior (GO:0035641)4.27051874
18synaptic vesicle maturation (GO:0016188)4.25851113
19establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.19171442
20mitochondrion transport along microtubule (GO:0047497)4.19171442
21exploration behavior (GO:0035640)4.17713702
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15188462
23neurotransmitter secretion (GO:0007269)4.12545819
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.10457900
25proline transport (GO:0015824)4.08592746
26neurofilament cytoskeleton organization (GO:0060052)3.99049867
27regulation of synapse structural plasticity (GO:0051823)3.94637290
28regulation of synaptic vesicle transport (GO:1902803)3.94051197
29glutamate receptor signaling pathway (GO:0007215)3.93593971
30neurotransmitter-gated ion channel clustering (GO:0072578)3.89446620
31axonal fasciculation (GO:0007413)3.88062240
32positive regulation of synapse maturation (GO:0090129)3.85698281
33postsynaptic membrane organization (GO:0001941)3.85086149
34nucleobase catabolic process (GO:0046113)3.83122542
35cell migration in hindbrain (GO:0021535)3.82579075
36dendritic spine morphogenesis (GO:0060997)3.81783037
37neuron-neuron synaptic transmission (GO:0007270)3.75426738
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.74047197
39synaptic transmission, glutamatergic (GO:0035249)3.70782428
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68940964
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.68401654
42presynaptic membrane assembly (GO:0097105)3.66559661
43synaptic vesicle endocytosis (GO:0048488)3.63233871
44regulation of neuronal synaptic plasticity (GO:0048168)3.57173876
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.46972855
46presynaptic membrane organization (GO:0097090)3.45946915
47neurotransmitter transport (GO:0006836)3.45836709
48positive regulation of synapse assembly (GO:0051965)3.45626316
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.45138683
50negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43816631
51neuronal ion channel clustering (GO:0045161)3.40820456
52neuronal action potential propagation (GO:0019227)3.40702125
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38326668
54dendrite morphogenesis (GO:0048813)3.31696532
55positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31209080
56regulation of postsynaptic membrane potential (GO:0060078)3.29099404
57axon extension (GO:0048675)3.28918726
58synapse assembly (GO:0007416)3.26382913
59gamma-aminobutyric acid transport (GO:0015812)3.25993985
60regulation of vesicle fusion (GO:0031338)3.25778006
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.23990215
62negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21849140
63regulation of neurotransmitter levels (GO:0001505)3.19922051
64innervation (GO:0060384)3.18247238
65regulation of neurotransmitter secretion (GO:0046928)3.17446791
66transmission of nerve impulse (GO:0019226)3.16050334
67regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.15533424
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.14778387
69regulation of synapse maturation (GO:0090128)3.11548211
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10705827
71response to auditory stimulus (GO:0010996)3.10658453
72response to histamine (GO:0034776)3.10327959
73energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10307268
74ATP hydrolysis coupled proton transport (GO:0015991)3.10307268
75long-term synaptic potentiation (GO:0060291)3.09696119
76positive regulation of membrane potential (GO:0045838)3.09503735
77positive regulation of dendritic spine morphogenesis (GO:0061003)3.08426087
78regulation of glutamate secretion (GO:0014048)3.07731877
79response to dietary excess (GO:0002021)3.07730635
80glycosphingolipid biosynthetic process (GO:0006688)3.07690182
81dendritic spine organization (GO:0097061)3.07399245
82synaptic vesicle transport (GO:0048489)3.06518443
83establishment of synaptic vesicle localization (GO:0097480)3.06518443
84behavioral fear response (GO:0001662)3.04379073
85behavioral defense response (GO:0002209)3.04379073
86regulation of dendritic spine morphogenesis (GO:0061001)3.04064087
87neuromuscular synaptic transmission (GO:0007274)3.02605749
88long-term memory (GO:0007616)3.02442499
89activation of protein kinase A activity (GO:0034199)3.00188028
90central nervous system projection neuron axonogenesis (GO:0021952)2.99782925
91fear response (GO:0042596)2.99614572
92regulation of synaptic plasticity (GO:0048167)2.98535247
93positive regulation of neurotransmitter transport (GO:0051590)2.97912051
94positive regulation of neurotransmitter secretion (GO:0001956)2.97389149
95hippocampus development (GO:0021766)2.96783498
96negative regulation of dendrite development (GO:2000171)2.95335221
97neuron projection extension (GO:1990138)2.95241652
98adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.95240442
99behavioral response to cocaine (GO:0048148)2.94053162
100response to pheromone (GO:0019236)2.92780600
101social behavior (GO:0035176)2.92510822
102intraspecies interaction between organisms (GO:0051703)2.92510822
103positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91927724
104behavioral response to nicotine (GO:0035095)2.91787143
105learning (GO:0007612)2.91783542
106regulation of neurotransmitter transport (GO:0051588)2.91372054
107membrane depolarization (GO:0051899)2.90247624
108synapse organization (GO:0050808)2.89902432
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89096196
110positive regulation of dendritic spine development (GO:0060999)2.87369475
111adult walking behavior (GO:0007628)2.87015380
112regulation of synapse assembly (GO:0051963)2.86416460
113organelle transport along microtubule (GO:0072384)2.86341095
114establishment of vesicle localization (GO:0051650)2.86267424
115auditory behavior (GO:0031223)2.85936308
116membrane hyperpolarization (GO:0060081)2.85667651
117positive regulation of mitochondrial fission (GO:0090141)2.85621215
118synaptic transmission (GO:0007268)2.84596304
119startle response (GO:0001964)2.83708772
120mechanosensory behavior (GO:0007638)2.81758373
121cerebellar granule cell differentiation (GO:0021707)2.81490138
122axon cargo transport (GO:0008088)2.80799785
123cellular potassium ion homeostasis (GO:0030007)2.79436546
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74867692
125regulation of voltage-gated calcium channel activity (GO:1901385)2.71752916
126membrane depolarization during action potential (GO:0086010)2.71593003
127positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70832403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.01854057
2GBX2_23144817_ChIP-Seq_PC3_Human3.86502885
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19103106
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12410670
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03337477
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78999077
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.77012480
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71953948
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.67065528
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66502778
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66502778
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63456527
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51763260
14* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.48021793
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46987330
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46135492
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43210261
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37684961
19TAF15_26573619_Chip-Seq_HEK293_Human2.36460984
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.35998205
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.26844651
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26765267
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.25988771
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25751495
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15997174
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.13390589
27AR_21572438_ChIP-Seq_LNCaP_Human2.12686845
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04099386
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.95432787
30DROSHA_22980978_ChIP-Seq_HELA_Human1.89564005
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88218120
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86722626
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.81813021
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74701200
35SMAD4_21799915_ChIP-Seq_A2780_Human1.68315908
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.66329512
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65942077
38P300_19829295_ChIP-Seq_ESCs_Human1.65296880
39ZNF274_21170338_ChIP-Seq_K562_Hela1.63715169
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57589268
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57218630
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51494927
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48835081
44IGF1R_20145208_ChIP-Seq_DFB_Human1.48305456
45RNF2_27304074_Chip-Seq_NSC_Mouse1.47765480
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.47182132
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45772937
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44965722
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42250398
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.41554400
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39045662
52AR_25329375_ChIP-Seq_VCAP_Human1.38874488
53GATA1_26923725_Chip-Seq_HPCs_Mouse1.36931897
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.36616463
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33776014
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.33731956
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.32372323
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31906989
59* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31288774
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30171569
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29871778
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29786881
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27762277
64VDR_22108803_ChIP-Seq_LS180_Human1.27071045
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.26226317
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25055275
67FUS_26573619_Chip-Seq_HEK293_Human1.23718030
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20005699
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19384471
70* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17108771
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14158609
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13407405
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12696338
74* JUN_21703547_ChIP-Seq_K562_Human1.11131120
75* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11062414
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10223609
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09185773
78STAT3_23295773_ChIP-Seq_U87_Human1.07935287
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.07302570
80RUNX2_22187159_ChIP-Seq_PCA_Human1.07091287
81PRDM14_20953172_ChIP-Seq_ESCs_Human1.06935948
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05944997
83AR_19668381_ChIP-Seq_PC3_Human1.05442056
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.03809296
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03173788
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01370287
87ER_23166858_ChIP-Seq_MCF-7_Human1.00751898
88POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00675870
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00675870
90TCF4_23295773_ChIP-Seq_U87_Human0.99204413
91DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98438517
92KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98271323
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98213019
94AHR_22903824_ChIP-Seq_MCF-7_Human0.97938001
95CTCF_27219007_Chip-Seq_Bcells_Human0.97592468
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.95032026
97BCAT_22108803_ChIP-Seq_LS180_Human0.94236287
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.93699499
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.93158588
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91830897
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90997402
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89967486
103POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89815271
104TP53_18474530_ChIP-ChIP_U2OS_Human0.89579461
105KDM2B_26808549_Chip-Seq_REH_Human0.88543372
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87978606
107SOX9_26525672_Chip-Seq_HEART_Mouse0.87834150
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.87174642
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86947855
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86392245
111IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86140703
112CBP_20019798_ChIP-Seq_JUKART_Human0.86140703
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84644341
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84621782
115POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.84485230
116E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.83965583
117REST_19997604_ChIP-ChIP_NEURONS_Mouse0.83503212
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.82106365
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.82102594
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.81772265
121POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81015780
122LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81009423
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79476642
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79356384
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79170723

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.13034646
2MP0003880_abnormal_central_pattern4.93259044
3MP0003635_abnormal_synaptic_transmissio3.80943833
4MP0004270_analgesia3.49708047
5MP0001968_abnormal_touch/_nociception3.38517909
6MP0002063_abnormal_learning/memory/cond3.20910937
7MP0009745_abnormal_behavioral_response3.15454414
8MP0006276_abnormal_autonomic_nervous3.00017812
9MP0002735_abnormal_chemical_nociception2.98988530
10MP0005423_abnormal_somatic_nervous2.89825839
11MP0002734_abnormal_mechanical_nocicepti2.85832063
12MP0002736_abnormal_nociception_after2.84960067
13MP0002064_seizures2.83969161
14MP0002572_abnormal_emotion/affect_behav2.74072486
15MP0009046_muscle_twitch2.62544327
16MP0002733_abnormal_thermal_nociception2.43564771
17MP0001440_abnormal_grooming_behavior2.37351180
18MP0002272_abnormal_nervous_system2.34960470
19MP0000778_abnormal_nervous_system2.33021581
20MP0002822_catalepsy2.27307415
21MP0002184_abnormal_innervation2.25374122
22MP0001486_abnormal_startle_reflex2.21529107
23MP0001970_abnormal_pain_threshold2.19848389
24MP0001529_abnormal_vocalization2.12898832
25MP0001501_abnormal_sleep_pattern2.05328087
26MP0004858_abnormal_nervous_system2.04182513
27MP0002067_abnormal_sensory_capabilities2.04023117
28MP0001984_abnormal_olfaction1.93096707
29MP0002557_abnormal_social/conspecific_i1.83748315
30MP0005386_behavior/neurological_phenoty1.82051715
31MP0004924_abnormal_behavior1.82051715
32MP0009780_abnormal_chondrocyte_physiolo1.79314265
33MP0003329_amyloid_beta_deposits1.78068210
34MP0004811_abnormal_neuron_physiology1.74128720
35MP0003122_maternal_imprinting1.72943574
36MP0001905_abnormal_dopamine_level1.70888598
37MP0000955_abnormal_spinal_cord1.59246872
38MP0005645_abnormal_hypothalamus_physiol1.55469839
39MP0010386_abnormal_urinary_bladder1.47274019
40MP0002882_abnormal_neuron_morphology1.47143728
41MP0002909_abnormal_adrenal_gland1.44834929
42MP0005646_abnormal_pituitary_gland1.43999325
43MP0003879_abnormal_hair_cell1.43193696
44MP0000751_myopathy1.39150354
45MP0002066_abnormal_motor_capabilities/c1.37202762
46MP0001188_hyperpigmentation1.32994825
47MP0008569_lethality_at_weaning1.31274519
48MP0004142_abnormal_muscle_tone1.31243316
49MP0002837_dystrophic_cardiac_calcinosis1.30712810
50MP0001502_abnormal_circadian_rhythm1.30015992
51MP0003787_abnormal_imprinting1.28382338
52MP0008877_abnormal_DNA_methylation1.25849830
53MP0002653_abnormal_ependyma_morphology1.19698487
54MP0004133_heterotaxia1.15823055
55MP0002152_abnormal_brain_morphology1.14369708
56MP0002638_abnormal_pupillary_reflex1.10130469
57MP0005499_abnormal_olfactory_system1.08205321
58MP0005394_taste/olfaction_phenotype1.08205321
59MP0005551_abnormal_eye_electrophysiolog1.00089290
60MP0004742_abnormal_vestibular_system0.99962062
61MP0004885_abnormal_endolymph0.99569053
62MP0003123_paternal_imprinting0.99297621
63MP0003633_abnormal_nervous_system0.97678557
64MP0002752_abnormal_somatic_nervous0.95369006
65MP0000631_abnormal_neuroendocrine_gland0.94491667
66MP0002069_abnormal_eating/drinking_beha0.94109756
67MP0000049_abnormal_middle_ear0.93690518
68MP0003631_nervous_system_phenotype0.90253619
69MP0002229_neurodegeneration0.89070687
70MP0008872_abnormal_physiological_respon0.88887685
71MP0001963_abnormal_hearing_physiology0.86319757
72MP0003890_abnormal_embryonic-extraembry0.84233059
73MP0003119_abnormal_digestive_system0.83765898
74MP0001299_abnormal_eye_distance/0.83486844
75MP0003634_abnormal_glial_cell0.82261767
76MP0004085_abnormal_heartbeat0.81406417
77MP0002876_abnormal_thyroid_physiology0.81193825
78MP0002090_abnormal_vision0.81101013
79MP0005535_abnormal_body_temperature0.81084877
80MP0002751_abnormal_autonomic_nervous0.80418838
81MP0000604_amyloidosis0.78970080
82MP0003938_abnormal_ear_development0.77994649
83MP0006292_abnormal_olfactory_placode0.76363497
84MP0009379_abnormal_foot_pigmentation0.74191022
85MP0002102_abnormal_ear_morphology0.73435121
86MP0005187_abnormal_penis_morphology0.72034162
87MP0008789_abnormal_olfactory_epithelium0.71678980
88MP0000569_abnormal_digit_pigmentation0.71413091
89MP0003861_abnormal_nervous_system0.69154681
90MP0001664_abnormal_digestion0.68866961
91MP0000013_abnormal_adipose_tissue0.68422406
92MP0004233_abnormal_muscle_weight0.68293469
93MP0002081_perinatal_lethality0.68219383
94MP0005623_abnormal_meninges_morphology0.67898468
95MP0000026_abnormal_inner_ear0.66875185
96MP0005253_abnormal_eye_physiology0.66039279
97MP0006072_abnormal_retinal_apoptosis0.65046685
98MP0008874_decreased_physiological_sensi0.64995979
99MP0003632_abnormal_nervous_system0.64590646
100MP0000538_abnormal_urinary_bladder0.64511161
101MP0003011_delayed_dark_adaptation0.64437531
102MP0001177_atelectasis0.64404889
103MP0000566_synostosis0.62783274
104MP0001485_abnormal_pinna_reflex0.62420476
105MP0003137_abnormal_impulse_conducting0.62032464
106MP0001986_abnormal_taste_sensitivity0.61666332
107MP0010769_abnormal_survival0.61538741
108MP0001943_abnormal_respiration0.60905885
109MP0005195_abnormal_posterior_eye0.60423964
110MP0003385_abnormal_body_wall0.59289452
111MP0010768_mortality/aging0.59145333
112MP0004215_abnormal_myocardial_fiber0.58703589
113MP0004145_abnormal_muscle_electrophysio0.58226056
114MP0003121_genomic_imprinting0.56726267
115MP0004484_altered_response_of0.54988364
116MP0002163_abnormal_gland_morphology0.54695042
117MP0005409_darkened_coat_color0.53978590
118MP0002082_postnatal_lethality0.52875500
119MP0010770_preweaning_lethality0.52875500
120MP0006035_abnormal_mitochondrial_morpho0.52450025

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.40595391
2Myokymia (HP:0002411)6.09663853
3Visual hallucinations (HP:0002367)5.28900700
4Focal seizures (HP:0007359)5.19156644
5Atonic seizures (HP:0010819)4.59100840
6Epileptic encephalopathy (HP:0200134)4.52350454
7Absence seizures (HP:0002121)4.18867597
8Cortical dysplasia (HP:0002539)4.17126611
9Progressive cerebellar ataxia (HP:0002073)4.06810261
10Febrile seizures (HP:0002373)4.06066162
11Limb dystonia (HP:0002451)3.98996250
12Dialeptic seizures (HP:0011146)3.73534437
13Generalized tonic-clonic seizures (HP:0002069)3.63501180
14Polyphagia (HP:0002591)3.56916834
15Amblyopia (HP:0000646)3.54995660
16Hyperventilation (HP:0002883)3.43261436
17Supranuclear gaze palsy (HP:0000605)3.30400513
18Mutism (HP:0002300)3.24332294
19Cerebral inclusion bodies (HP:0100314)3.04267951
20Pheochromocytoma (HP:0002666)3.02547161
21Broad-based gait (HP:0002136)3.00537352
22Ankle clonus (HP:0011448)2.99677911
23Excessive salivation (HP:0003781)2.98052773
24Drooling (HP:0002307)2.98052773
25Abnormal eating behavior (HP:0100738)2.97569182
26Action tremor (HP:0002345)2.92161551
27Failure to thrive in infancy (HP:0001531)2.91837676
28Retinal dysplasia (HP:0007973)2.91222769
29Termporal pattern (HP:0011008)2.87171962
30Insidious onset (HP:0003587)2.87171962
31Pachygyria (HP:0001302)2.82540277
32Progressive inability to walk (HP:0002505)2.80201487
33Split foot (HP:0001839)2.78672895
34Anxiety (HP:0000739)2.74972690
35Spastic tetraplegia (HP:0002510)2.74922302
36Neuroendocrine neoplasm (HP:0100634)2.71088900
37Poor suck (HP:0002033)2.65892860
38Gait imbalance (HP:0002141)2.62186896
39Truncal ataxia (HP:0002078)2.61502289
40Abnormality of the corticospinal tract (HP:0002492)2.61384163
41Impaired vibration sensation in the lower limbs (HP:0002166)2.59921081
42Depression (HP:0000716)2.59646043
43Poor eye contact (HP:0000817)2.58991508
44Amyotrophic lateral sclerosis (HP:0007354)2.58832103
45Cerebral hypomyelination (HP:0006808)2.56720619
46Acute necrotizing encephalopathy (HP:0006965)2.54713532
47Akinesia (HP:0002304)2.49760189
48Hemiparesis (HP:0001269)2.44951300
49Neurofibrillary tangles (HP:0002185)2.43520020
50Abnormal hair whorl (HP:0010721)2.43386953
51Torticollis (HP:0000473)2.43189814
52Urinary bladder sphincter dysfunction (HP:0002839)2.42514893
53Fetal akinesia sequence (HP:0001989)2.42206402
54Urinary urgency (HP:0000012)2.39491063
55Impaired social interactions (HP:0000735)2.37724346
56Abnormal social behavior (HP:0012433)2.37724346
57Progressive macrocephaly (HP:0004481)2.37139289
58Diplopia (HP:0000651)2.36040852
59Abnormality of binocular vision (HP:0011514)2.36040852
60Abnormal mitochondria in muscle tissue (HP:0008316)2.34208969
61Peripheral hypomyelination (HP:0007182)2.34065189
62Hypoventilation (HP:0002791)2.33810890
63Inability to walk (HP:0002540)2.32352171
64Dysdiadochokinesis (HP:0002075)2.31713922
65Abnormality of the lower motor neuron (HP:0002366)2.31661877
66Delusions (HP:0000746)2.31539979
67Lissencephaly (HP:0001339)2.29691431
68Agitation (HP:0000713)2.29079987
69Focal dystonia (HP:0004373)2.28088632
70* Epileptiform EEG discharges (HP:0011182)2.24215831
71Spastic gait (HP:0002064)2.22674404
72Specific learning disability (HP:0001328)2.20039723
73Shoulder girdle muscle weakness (HP:0003547)2.19900549
74Atrophy/Degeneration involving motor neurons (HP:0007373)2.17534265
75Esotropia (HP:0000565)2.16883538
76* EEG with generalized epileptiform discharges (HP:0011198)2.15554486
77Craniofacial dystonia (HP:0012179)2.14387934
78* Aplasia/Hypoplasia of the brainstem (HP:0007362)2.12499165
79* Hypoplasia of the brainstem (HP:0002365)2.12499165
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.11531841
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.11531841
82Gaze-evoked nystagmus (HP:0000640)2.11446225
83Hyperthyroidism (HP:0000836)2.11113860
84Nephrogenic diabetes insipidus (HP:0009806)2.10881054
85Hand muscle atrophy (HP:0009130)2.10139987
86Bradykinesia (HP:0002067)2.08171373
87* Hypoplasia of the corpus callosum (HP:0002079)2.06643874
88Hepatoblastoma (HP:0002884)2.06250800
89Dysmetria (HP:0001310)2.05770616
90Absent speech (HP:0001344)2.01927472
91Hypothermia (HP:0002045)2.01563469
92CNS hypomyelination (HP:0003429)2.01426896
93Intention tremor (HP:0002080)2.00262285
94Abnormality of salivation (HP:0100755)2.00033057
95Sleep apnea (HP:0010535)1.97894423
96Psychosis (HP:0000709)1.97693630
97Impaired pain sensation (HP:0007328)1.97253113
98Abnormality of pain sensation (HP:0010832)1.97253113
99Polymicrogyria (HP:0002126)1.96896885
100Lower limb muscle weakness (HP:0007340)1.96842473
101Muscular hypotonia of the trunk (HP:0008936)1.95298355
102Morphological abnormality of the pyramidal tract (HP:0002062)1.93649947
103* Hypsarrhythmia (HP:0002521)1.93538271
104Generalized myoclonic seizures (HP:0002123)1.93187375
105Medial flaring of the eyebrow (HP:0010747)1.92900018
106Congenital primary aphakia (HP:0007707)1.91508565
107Narrow nasal bridge (HP:0000446)1.91197713
108Genetic anticipation (HP:0003743)1.91114045
109Exotropia (HP:0000577)1.90098479
110Status epilepticus (HP:0002133)1.89606564
111Ulnar claw (HP:0001178)1.88453229
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.87368415
113Vaginal atresia (HP:0000148)1.85876288
114Megalencephaly (HP:0001355)1.84967582
115Acute encephalopathy (HP:0006846)1.84931352
116Abnormality of the labia minora (HP:0012880)1.83512562
117Neoplasm of the peripheral nervous system (HP:0100007)1.83438399
118Papilledema (HP:0001085)1.82596320
119Rapidly progressive (HP:0003678)1.81888956
120Genital tract atresia (HP:0001827)1.81520685
121Postural instability (HP:0002172)1.81227451
122Hammertoe (HP:0001765)1.79089464
123Apathy (HP:0000741)1.78578801
124Upper limb muscle weakness (HP:0003484)1.77745739
125Generalized hypotonia (HP:0001290)1.76132416
126Abnormality of the musculature of the pelvis (HP:0001469)1.75110088
127Abnormality of the hip-girdle musculature (HP:0001445)1.75110088
128Paraplegia (HP:0010550)1.75080154
129Type II lissencephaly (HP:0007260)1.74000128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.65504582
2NTRK33.49352367
3MAP3K123.34104610
4MAP3K43.29201169
5MAP3K93.28828501
6CASK3.14564324
7MINK12.97817742
8MAP2K72.96343305
9EPHA42.88785528
10NTRK22.31219204
11MAP2K42.08226003
12MAPK132.05389378
13DAPK22.03921493
14GRK51.98725907
15PNCK1.96850353
16PLK21.89649491
17PAK61.76280198
18TRIM281.68675046
19MAP4K21.66647083
20NTRK11.64771643
21KSR11.64406982
22SIK21.58801065
23PINK11.54964208
24NME11.53442135
25PHKG21.52735330
26PHKG11.52735330
27DAPK11.48666440
28KSR21.46096307
29CDK51.40401351
30LATS21.35107047
31ARAF1.34565680
32RIPK41.34538537
33DYRK21.34394555
34PRKCG1.22796196
35UHMK11.22316605
36TNIK1.16169876
37TESK11.15235387
38CSNK1G21.10396210
39EPHA31.09462802
40DYRK1A1.07724712
41CAMK2A1.07390526
42CDK191.07139664
43CAMKK11.01587329
44CDK141.00993885
45CDK181.00166143
46SIK30.95532230
47GRK70.95186937
48CDK150.94700953
49PRPF4B0.93648173
50PAK30.91382349
51PTK2B0.89380018
52EPHB20.89257906
53FGR0.88887520
54LIMK10.85589450
55BCR0.83801362
56CDK11A0.82327336
57FES0.80307647
58ERBB30.79940580
59CAMK2B0.78086691
60CSNK1G30.76949826
61DYRK1B0.76796212
62ADRBK10.76060219
63PRKCE0.75744740
64WNK30.73155218
65BCKDK0.71656705
66CAMKK20.71150022
67SGK4940.68062317
68SGK2230.68062317
69DYRK30.65418163
70RET0.64762229
71PRKD30.64168398
72MAP3K60.63498002
73TYRO30.63446171
74FER0.61589076
75PRKCZ0.61362514
76BMPR20.59576713
77GRK60.58590636
78MARK20.57018667
79MAP3K20.56617827
80BMPR1B0.55661642
81LMTK20.55609394
82STK380.55044980
83OXSR10.53506282
84MAP2K10.52677225
85STK110.51473001
86RPS6KA20.50075248
87SRPK10.49397561
88ADRBK20.48994919
89TESK20.48229058
90PIM20.47043892
91CSNK1E0.46487212
92CAMK2D0.46175649
93MAP3K110.45530593
94CSNK1D0.44259839
95PKN10.44066348
96RAF10.43799454
97SGK20.43419604
98MAPK120.43322957
99CAMK40.42036813
100CAMK10.41881337
101CSNK1A1L0.41866936
102SGK10.41321584
103TSSK60.41042414
104ROCK20.40109461
105PRKCH0.39047726
106DAPK30.38430109
107PRKAA10.37852610
108CAMK2G0.37150752
109MAPK90.36638611
110CAMK1G0.35782623
111FYN0.35744075
112CSNK1A10.35461372
113CSNK1G10.35214285
114PDK30.34212263
115PDK40.34212263
116CCNB10.34088598
117PRKACA0.33205074
118BRAF0.33170737
119PRKCB0.31733351
120RPS6KA30.31314345
121TAOK10.31306651
122AURKA0.31079036
123STK160.29683701
124ALK0.29279666
125MAPK100.29264964
126PRKACB0.27742443
127WNK40.27448416

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00724270
2Synaptic vesicle cycle_Homo sapiens_hsa047213.76966952
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70993122
4GABAergic synapse_Homo sapiens_hsa047272.62955493
5Collecting duct acid secretion_Homo sapiens_hsa049662.51931707
6Olfactory transduction_Homo sapiens_hsa047402.41598876
7Circadian entrainment_Homo sapiens_hsa047132.39191169
8Morphine addiction_Homo sapiens_hsa050322.33018766
9Glutamatergic synapse_Homo sapiens_hsa047242.30767154
10Long-term potentiation_Homo sapiens_hsa047202.27202047
11Dopaminergic synapse_Homo sapiens_hsa047282.20028724
12Amphetamine addiction_Homo sapiens_hsa050312.17974064
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.07762078
14Oxidative phosphorylation_Homo sapiens_hsa001902.06882073
15Taste transduction_Homo sapiens_hsa047421.97901817
16Serotonergic synapse_Homo sapiens_hsa047261.89617241
17Cholinergic synapse_Homo sapiens_hsa047251.83249808
18Salivary secretion_Homo sapiens_hsa049701.82714571
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81889416
20Insulin secretion_Homo sapiens_hsa049111.72832509
21Steroid biosynthesis_Homo sapiens_hsa001001.69048554
22Parkinsons disease_Homo sapiens_hsa050121.66314789
23Long-term depression_Homo sapiens_hsa047301.65725147
24Renin secretion_Homo sapiens_hsa049241.65375308
25Vibrio cholerae infection_Homo sapiens_hsa051101.61125408
26Cocaine addiction_Homo sapiens_hsa050301.60555290
27Alzheimers disease_Homo sapiens_hsa050101.57490813
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56672082
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54575838
30Gastric acid secretion_Homo sapiens_hsa049711.50591481
31Cardiac muscle contraction_Homo sapiens_hsa042601.48513987
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47104016
33Axon guidance_Homo sapiens_hsa043601.42844595
34Oxytocin signaling pathway_Homo sapiens_hsa049211.42333694
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42160966
36Calcium signaling pathway_Homo sapiens_hsa040201.38699647
37* Gap junction_Homo sapiens_hsa045401.36456202
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28841831
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27436606
40GnRH signaling pathway_Homo sapiens_hsa049121.27152631
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26425587
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16688823
43Huntingtons disease_Homo sapiens_hsa050161.11675051
44* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.01291021
45Estrogen signaling pathway_Homo sapiens_hsa049151.00340742
46Phototransduction_Homo sapiens_hsa047440.96303168
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95182946
48Glioma_Homo sapiens_hsa052140.92494343
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91860509
50Melanogenesis_Homo sapiens_hsa049160.91073045
51ErbB signaling pathway_Homo sapiens_hsa040120.90351999
52cAMP signaling pathway_Homo sapiens_hsa040240.89679885
53Type II diabetes mellitus_Homo sapiens_hsa049300.87078601
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85087146
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.78778305
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78733940
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73543300
58Hippo signaling pathway_Homo sapiens_hsa043900.72665831
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.72030250
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71577382
61Oocyte meiosis_Homo sapiens_hsa041140.68399628
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67148730
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63911175
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.63600310
65Butanoate metabolism_Homo sapiens_hsa006500.63283795
66Protein export_Homo sapiens_hsa030600.61681746
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61151612
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60310863
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59665244
70Rheumatoid arthritis_Homo sapiens_hsa053230.57715816
71* Phagosome_Homo sapiens_hsa041450.57529757
72Dilated cardiomyopathy_Homo sapiens_hsa054140.57519985
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56979377
74MAPK signaling pathway_Homo sapiens_hsa040100.56974042
75Vitamin B6 metabolism_Homo sapiens_hsa007500.56712935
76Alcoholism_Homo sapiens_hsa050340.56391082
77Regulation of autophagy_Homo sapiens_hsa041400.53959452
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52859098
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.51031615
80Ras signaling pathway_Homo sapiens_hsa040140.50343874
81Pancreatic secretion_Homo sapiens_hsa049720.50306054
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.50217023
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49800136
84Choline metabolism in cancer_Homo sapiens_hsa052310.49396380
85Thyroid hormone synthesis_Homo sapiens_hsa049180.48469290
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48293094
87Fatty acid elongation_Homo sapiens_hsa000620.47314884
88AMPK signaling pathway_Homo sapiens_hsa041520.47075558
89Glucagon signaling pathway_Homo sapiens_hsa049220.46952983
90Prion diseases_Homo sapiens_hsa050200.45515328
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45508826
92Dorso-ventral axis formation_Homo sapiens_hsa043200.45119218
93Colorectal cancer_Homo sapiens_hsa052100.43397663
94VEGF signaling pathway_Homo sapiens_hsa043700.43262268
95Endometrial cancer_Homo sapiens_hsa052130.42519820
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42381607
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42212358
98Type I diabetes mellitus_Homo sapiens_hsa049400.41896913
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41636498
100Hedgehog signaling pathway_Homo sapiens_hsa043400.41321007
101Tight junction_Homo sapiens_hsa045300.41143709
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.40356955
103Insulin signaling pathway_Homo sapiens_hsa049100.38944472
104Arginine and proline metabolism_Homo sapiens_hsa003300.38687803
105Renal cell carcinoma_Homo sapiens_hsa052110.38538317
106Ether lipid metabolism_Homo sapiens_hsa005650.38484192
107Biosynthesis of amino acids_Homo sapiens_hsa012300.38320745
108Rap1 signaling pathway_Homo sapiens_hsa040150.37108077
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36906584
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35311133
111African trypanosomiasis_Homo sapiens_hsa051430.33534088
112Wnt signaling pathway_Homo sapiens_hsa043100.32519318
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32403328
114beta-Alanine metabolism_Homo sapiens_hsa004100.30718138
115Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30020160
116Endocytosis_Homo sapiens_hsa041440.29687738
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28327447
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27775352
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27623351
120Fatty acid metabolism_Homo sapiens_hsa012120.27306510
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27076891
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26849579
123Salmonella infection_Homo sapiens_hsa051320.26445162
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25686911
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24414333
126Bile secretion_Homo sapiens_hsa049760.23616442
127Circadian rhythm_Homo sapiens_hsa047100.23474048

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