ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	pyrimidine nucleobase catabolic process (GO:0006208)	7.65583791
2	nucleobase catabolic process (GO:0046113)	5.95799473
3	positive regulation of mitochondrial fission (GO:0090141)	5.67023870
4	gamma-aminobutyric acid transport (GO:0015812)	5.26422794
5	establishment of mitochondrion localization (GO:0051654)	4.67579711
6	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.25295187
7	neuron cell-cell adhesion (GO:0007158)	4.15696926
8	negative regulation of oligodendrocyte differentiation (GO:0048715)	3.93641534
9	regulation of mitochondrial fission (GO:0090140)	3.83174820
10	protein localization to synapse (GO:0035418)	3.80200654
11	sequestering of actin monomers (GO:0042989)	3.78974435
12	synaptic vesicle exocytosis (GO:0016079)	3.71880991
13	de novo posttranslational protein folding (GO:0051084)	3.65904589
14	synapse assembly (GO:0007416)	3.64872830
15	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.64463611
16	postsynaptic membrane organization (GO:0001941)	3.59406016
17	presynaptic membrane assembly (GO:0097105)	3.56357020
18	vocalization behavior (GO:0071625)	3.55391173
19	glycosphingolipid biosynthetic process (GO:0006688)	3.52470818
20	regulation of feeding behavior (GO:0060259)	3.50177197
21	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.48778641
22	presynaptic membrane organization (GO:0097090)	3.46178130
23	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.42696813
24	behavioral response to nicotine (GO:0035095)	3.36574388
25	de novo protein folding (GO:0006458)	3.34328977
26	ribonucleoprotein complex disassembly (GO:0032988)	3.33393297
27	protein insertion into membrane (GO:0051205)	3.29262263
28	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.28555293
29	L-serine transport (GO:0015825)	3.24015992
30	hippocampus development (GO:0021766)	3.18403025
31	protein deneddylation (GO:0000338)	3.16272511
32	synaptic vesicle maturation (GO:0016188)	3.15816460
33	response to dietary excess (GO:0002021)	3.14561147
34	DNA integration (GO:0015074)	3.12218709
35	protein polyglutamylation (GO:0018095)	3.11882833
36	axonal fasciculation (GO:0007413)	3.10173727
37	cullin deneddylation (GO:0010388)	3.08600731
38	positive regulation of synapse assembly (GO:0051965)	3.06509052
39	cell migration in hindbrain (GO:0021535)	3.03450493
40	neurotransmitter secretion (GO:0007269)	2.99490537
41	protein localization to cilium (GO:0061512)	2.97169560
42	negative regulation of microtubule polymerization (GO:0031115)	2.95997141
43	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.95680567
44	ATP hydrolysis coupled proton transport (GO:0015991)	2.95680567
45	positive regulation of TOR signaling (GO:0032008)	2.93952650
46	regulation of development, heterochronic (GO:0040034)	2.93205943
47	neuron recognition (GO:0008038)	2.88615825
48	iron-sulfur cluster assembly (GO:0016226)	2.86741094
49	metallo-sulfur cluster assembly (GO:0031163)	2.86741094
50	amino acid salvage (GO:0043102)	2.82898395
51	L-methionine salvage (GO:0071267)	2.82898395
52	L-methionine biosynthetic process (GO:0071265)	2.82898395
53	regulation of cilium movement (GO:0003352)	2.81941234
54	neurotransmitter biosynthetic process (GO:0042136)	2.79963425
55	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.78572718
56	ubiquinone metabolic process (GO:0006743)	2.75695313
57	regulation of vesicle fusion (GO:0031338)	2.74373381
58	DNA damage response, detection of DNA damage (GO:0042769)	2.73763152
59	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.73536566
60	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.73536566
61	synaptic vesicle endocytosis (GO:0048488)	2.73518058
62	negative regulation of telomere maintenance (GO:0032205)	2.72726716
63	establishment of melanosome localization (GO:0032401)	2.72707600
64	glycine transport (GO:0015816)	2.71622261
65	peroxisome fission (GO:0016559)	2.70573191
66	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.70362597
67	nonmotile primary cilium assembly (GO:0035058)	2.70266070
68	regulation of synapse structural plasticity (GO:0051823)	2.69710821
69	organelle disassembly (GO:1903008)	2.68961180
70	glutamate secretion (GO:0014047)	2.68110188
71	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.65293488
72	regulation of oligodendrocyte differentiation (GO:0048713)	2.65084327
73	protein-cofactor linkage (GO:0018065)	2.64874428
74	establishment of vesicle localization (GO:0051650)	2.63234341
75	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.62670922
76	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.62612075
77	mitochondrion transport along microtubule (GO:0047497)	2.62612075
78	melanosome transport (GO:0032402)	2.62490375
79	dendritic spine morphogenesis (GO:0060997)	2.61718327
80	C4-dicarboxylate transport (GO:0015740)	2.59793515
81	auditory behavior (GO:0031223)	2.59272319
82	regulation of synaptic vesicle exocytosis (GO:2000300)	2.56680960
83	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.55354156
84	forebrain neuron differentiation (GO:0021879)	2.54710665
85	establishment of pigment granule localization (GO:0051905)	2.53937717
86	olfactory bulb development (GO:0021772)	2.53883633
87	establishment of synaptic vesicle localization (GO:0097480)	2.53535852
88	synaptic vesicle transport (GO:0048489)	2.53535852
89	water-soluble vitamin biosynthetic process (GO:0042364)	2.53489877
90	negative regulation of membrane potential (GO:0045837)	2.52910330
91	melanosome localization (GO:0032400)	2.52435744
92	cerebral cortex radially oriented cell migration (GO:0021799)	2.51914974
93	neuronal action potential propagation (GO:0019227)	2.51903203
94	head development (GO:0060322)	2.50812532
95	retinal cone cell development (GO:0046549)	2.50617903
96	synaptic transmission, glutamatergic (GO:0035249)	2.49894500
97	serine transport (GO:0032329)	2.49882912
98	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.48784291
99	base-excision repair, AP site formation (GO:0006285)	2.48148006
100	peptidyl-arginine omega-N-methylation (GO:0035247)	2.46953566

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.77447343
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.84970847
3	IGF1R_20145208_ChIP-Seq_DFB_Human	3.80572620
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.67862413
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.92092849
6	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.82269257
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.73431341
8	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.66942864
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.56450967
10	GBX2_23144817_ChIP-Seq_PC3_Human	2.51817351
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.45467320
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.41513315
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.40235563
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.33888867
15	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.27003547
16	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.26974968
17	EZH2_22144423_ChIP-Seq_EOC_Human	2.19038988
18	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.02718875
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.99532682
20	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.93132532
21	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.92714842
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85544684
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.76567404
24	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74183358
25	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70451317
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.70296532
27	FUS_26573619_Chip-Seq_HEK293_Human	1.69205770
28	VDR_22108803_ChIP-Seq_LS180_Human	1.67113299
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63464064
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.60051767
31	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.59916468
32	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.58989515
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57978954
34	P300_19829295_ChIP-Seq_ESCs_Human	1.54407821
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50772191
36	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50582025
37	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.50551048
38	RNF2_27304074_Chip-Seq_NSC_Mouse	1.48588657
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.48410973
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.42828637
41	EWS_26573619_Chip-Seq_HEK293_Human	1.42490665
42	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.41329666
43	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.38938161
44	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.38336482
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.35334981
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35133992
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.34600729
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34600729
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.32798708
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31378623
51	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.30312647
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.24951286
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.23873697
54	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.21242114
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17159764
56	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.16369616
57	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.14045737
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.13494914
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.11978039
60	TP53_22573176_ChIP-Seq_HFKS_Human	1.09904028
61	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.09133729
62	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08910415
63	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.08149955
64	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.06313707
65	MYC_18940864_ChIP-ChIP_HL60_Human	1.05024675
66	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02892001
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02671067
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.01488570
69	JUN_21703547_ChIP-Seq_K562_Human	1.01363892
70	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.01359618
71	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.00736978
72	SMAD4_21799915_ChIP-Seq_A2780_Human	1.00054557
73	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98587563
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.97687978
75	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.97012125
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.94158885
77	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.93410186
78	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92905241
79	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.92651005
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89815922
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.89788703
82	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.89550204
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.88918062
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.88594785
85	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.88565897
86	AR_25329375_ChIP-Seq_VCAP_Human	0.88221232
87	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88187194
88	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.87848035
89	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.87610676
90	STAT3_23295773_ChIP-Seq_U87_Human	0.86309559
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.85727497
92	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.85115793
93	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.83770825
94	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.83107451
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.83077476
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.82914320
97	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.82716891
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82665116
99	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.81626225
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.81608532

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	3.89899448
2	MP0002822_catalepsy	3.63657530
3	MP0001529_abnormal_vocalization	3.48770968
4	MP0008789_abnormal_olfactory_epithelium	2.97046989
5	MP0004859_abnormal_synaptic_plasticity	2.95321412
6	MP0001984_abnormal_olfaction	2.93177134
7	MP0004270_analgesia	2.92452753
8	MP0005394_taste/olfaction_phenotype	2.91963416
9	MP0005499_abnormal_olfactory_system	2.91963416
10	MP0003122_maternal_imprinting	2.78595452
11	MP0000778_abnormal_nervous_system	2.35515960
12	MP0006276_abnormal_autonomic_nervous	2.32055731
13	MP0002736_abnormal_nociception_after	2.30830805
14	MP0003221_abnormal_cardiomyocyte_apopto	2.19712061
15	MP0003880_abnormal_central_pattern	2.10094449
16	MP0003635_abnormal_synaptic_transmissio	2.05694636
17	MP0000049_abnormal_middle_ear	2.03446086
18	MP0009046_muscle_twitch	1.99320319
19	MP0001968_abnormal_touch/_nociception	1.87829589
20	MP0002735_abnormal_chemical_nociception	1.82956971
21	MP0002063_abnormal_learning/memory/cond	1.78185678
22	MP0002572_abnormal_emotion/affect_behav	1.73611979
23	MP0003121_genomic_imprinting	1.72468170
24	MP0009745_abnormal_behavioral_response	1.71916836
25	MP0005645_abnormal_hypothalamus_physiol	1.70523886
26	MP0002653_abnormal_ependyma_morphology	1.69175150
27	MP0004811_abnormal_neuron_physiology	1.66594482
28	MP0005360_urolithiasis	1.66204403
29	MP0003011_delayed_dark_adaptation	1.60492599
30	MP0004142_abnormal_muscle_tone	1.57745622
31	MP0001486_abnormal_startle_reflex	1.55457810
32	MP0002557_abnormal_social/conspecific_i	1.55202584
33	MP0002064_seizures	1.53614683
34	MP0002272_abnormal_nervous_system	1.52813028
35	MP0001270_distended_abdomen	1.50068610
36	MP0005253_abnormal_eye_physiology	1.49290028
37	MP0001188_hyperpigmentation	1.48891242
38	MP0002734_abnormal_mechanical_nocicepti	1.47722867
39	MP0002751_abnormal_autonomic_nervous	1.47600110
40	MP0006072_abnormal_retinal_apoptosis	1.47480258
41	MP0001905_abnormal_dopamine_level	1.43878578
42	MP0002638_abnormal_pupillary_reflex	1.37222652
43	MP0003938_abnormal_ear_development	1.30509512
44	MP0002882_abnormal_neuron_morphology	1.29958592
45	MP0004924_abnormal_behavior	1.26693016
46	MP0005386_behavior/neurological_phenoty	1.26693016
47	MP0002733_abnormal_thermal_nociception	1.25865711
48	MP0002234_abnormal_pharynx_morphology	1.25678110
49	MP0000955_abnormal_spinal_cord	1.24562456
50	MP0002909_abnormal_adrenal_gland	1.23529438
51	MP0005084_abnormal_gallbladder_morpholo	1.22593937
52	MP0002184_abnormal_innervation	1.21647250
53	MP0001502_abnormal_circadian_rhythm	1.20827704
54	MP0001970_abnormal_pain_threshold	1.19544283
55	MP0004133_heterotaxia	1.18495244
56	MP0003890_abnormal_embryonic-extraembry	1.16165296
57	MP0002837_dystrophic_cardiac_calcinosis	1.15956539
58	MP0002067_abnormal_sensory_capabilities	1.15654066
59	MP0008877_abnormal_DNA_methylation	1.09922954
60	MP0002233_abnormal_nose_morphology	1.09852149
61	MP0002752_abnormal_somatic_nervous	1.08519818
62	MP0002069_abnormal_eating/drinking_beha	1.08067580
63	MP0005423_abnormal_somatic_nervous	1.07325834
64	MP0003787_abnormal_imprinting	1.06134730
65	MP0000026_abnormal_inner_ear	1.01976720
66	MP0000751_myopathy	1.00715720
67	MP0002152_abnormal_brain_morphology	0.99062100
68	MP0002066_abnormal_motor_capabilities/c	0.98769879
69	MP0000013_abnormal_adipose_tissue	0.97033745
70	MP0000631_abnormal_neuroendocrine_gland	0.95903661
71	MP0008995_early_reproductive_senescence	0.95029237
72	MP0004885_abnormal_endolymph	0.94482991
73	MP0005551_abnormal_eye_electrophysiolog	0.94473039
74	MP0005187_abnormal_penis_morphology	0.93585544
75	MP0001986_abnormal_taste_sensitivity	0.91114949
76	MP0005646_abnormal_pituitary_gland	0.89471487
77	MP0003567_abnormal_fetal_cardiomyocyte	0.88146020
78	MP0004742_abnormal_vestibular_system	0.87367554
79	MP0003329_amyloid_beta_deposits	0.86389302
80	MP0003861_abnormal_nervous_system	0.86276727
81	MP0003755_abnormal_palate_morphology	0.86154397
82	MP0004147_increased_porphyrin_level	0.85636446
83	MP0000647_abnormal_sebaceous_gland	0.85402891
84	MP0003137_abnormal_impulse_conducting	0.85396652
85	MP0003937_abnormal_limbs/digits/tail_de	0.83923658
86	MP0006292_abnormal_olfactory_placode	0.78254805
87	MP0006035_abnormal_mitochondrial_morpho	0.76781724
88	MP0003119_abnormal_digestive_system	0.76710243
89	MP0005391_vision/eye_phenotype	0.75559388
90	MP0004043_abnormal_pH_regulation	0.74692875
91	MP0001299_abnormal_eye_distance/	0.74608149
92	MP0005623_abnormal_meninges_morphology	0.73703257
93	MP0002177_abnormal_outer_ear	0.69311994
94	MP0003385_abnormal_body_wall	0.69132818
95	MP0002229_neurodegeneration	0.68814461
96	MP0005195_abnormal_posterior_eye	0.67905867
97	MP0002249_abnormal_larynx_morphology	0.67042907
98	MP0001440_abnormal_grooming_behavior	0.66739827
99	MP0002332_abnormal_exercise_endurance	0.66290337
100	MP0005248_abnormal_Harderian_gland	0.65915201

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cortical dysplasia (HP:0002539)	4.99455409
2	Polyphagia (HP:0002591)	3.52768346
3	Shoulder girdle muscle weakness (HP:0003547)	3.49667544
4	Lissencephaly (HP:0001339)	3.49176171
5	Split foot (HP:0001839)	3.41755940
6	Pachygyria (HP:0001302)	3.37408094
7	Aplasia/Hypoplasia of the brainstem (HP:0007362)	3.30214083
8	Hypoplasia of the brainstem (HP:0002365)	3.30214083
9	Retinal dysplasia (HP:0007973)	3.28658257
10	Drooling (HP:0002307)	3.28291580
11	Amyotrophic lateral sclerosis (HP:0007354)	3.25467109
12	Abnormality of the musculature of the pelvis (HP:0001469)	3.20090548
13	Abnormality of the hip-girdle musculature (HP:0001445)	3.20090548
14	Hyperglycinemia (HP:0002154)	3.11608017
15	Poor suck (HP:0002033)	3.03811000
16	Upper limb muscle weakness (HP:0003484)	3.00285669
17	Excessive salivation (HP:0003781)	2.98675587
18	Gait imbalance (HP:0002141)	2.92047282
19	Failure to thrive in infancy (HP:0001531)	2.88393898
20	Abnormality of the labia minora (HP:0012880)	2.86684286
21	Limb dystonia (HP:0002451)	2.84355867
22	Urinary urgency (HP:0000012)	2.83995546
23	Hand muscle atrophy (HP:0009130)	2.81231169
24	Medial flaring of the eyebrow (HP:0010747)	2.80460428
25	Nephrogenic diabetes insipidus (HP:0009806)	2.74906937
26	Spastic gait (HP:0002064)	2.74510610
27	Pelvic girdle muscle weakness (HP:0003749)	2.70341393
28	Congenital primary aphakia (HP:0007707)	2.70109757
29	Ankle clonus (HP:0011448)	2.70038388
30	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.67160331
31	Specific learning disability (HP:0001328)	2.53807267
32	Absent speech (HP:0001344)	2.48036915
33	Pendular nystagmus (HP:0012043)	2.46929630
34	Esotropia (HP:0000565)	2.45196583
35	Polymicrogyria (HP:0002126)	2.45007473
36	Abnormality of the lower motor neuron (HP:0002366)	2.44860962
37	Hypsarrhythmia (HP:0002521)	2.44833267
38	Hemiparesis (HP:0001269)	2.43378649
39	Abnormality of the corticospinal tract (HP:0002492)	2.41970106
40	Spastic tetraplegia (HP:0002510)	2.41472757
41	Progressive inability to walk (HP:0002505)	2.40987580
42	Lower limb muscle weakness (HP:0007340)	2.38618353
43	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.37100889
44	EEG with generalized epileptiform discharges (HP:0011198)	2.33483418
45	Wrist flexion contracture (HP:0001239)	2.28292957
46	Rimmed vacuoles (HP:0003805)	2.26933685
47	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.24927025
48	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.24927025
49	Epileptiform EEG discharges (HP:0011182)	2.23556810
50	CNS hypomyelination (HP:0003429)	2.19411153
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.13736441
52	Abnormality of alanine metabolism (HP:0010916)	2.13736441
53	Hyperalaninemia (HP:0003348)	2.13736441
54	Amblyopia (HP:0000646)	2.12542332
55	Impaired vibration sensation in the lower limbs (HP:0002166)	2.11401584
56	Type II lissencephaly (HP:0007260)	2.11218139
57	Acute necrotizing encephalopathy (HP:0006965)	2.11048852
58	Hypoplasia of the corpus callosum (HP:0002079)	2.10911721
59	Paraplegia (HP:0010550)	2.10619868
60	Increased serum pyruvate (HP:0003542)	2.10557975
61	Inability to walk (HP:0002540)	2.10544015
62	Mutism (HP:0002300)	2.09843159
63	Muscular hypotonia of the trunk (HP:0008936)	2.09589715
64	Peripheral hypomyelination (HP:0007182)	2.09226006
65	Abnormality of the metopic suture (HP:0005556)	2.06580179
66	Myokymia (HP:0002411)	2.05910927
67	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04728822
68	Abnormal eating behavior (HP:0100738)	2.02645742
69	Severe muscular hypotonia (HP:0006829)	2.01975124
70	Pancreatic cysts (HP:0001737)	2.01777177
71	Increased CSF lactate (HP:0002490)	1.99541683
72	Methylmalonic acidemia (HP:0002912)	1.97626639
73	Vaginal atresia (HP:0000148)	1.94422781
74	Genital tract atresia (HP:0001827)	1.94260951
75	True hermaphroditism (HP:0010459)	1.92917554
76	Autoamputation (HP:0001218)	1.92787817
77	Acute encephalopathy (HP:0006846)	1.91930525
78	Distal upper limb amyotrophy (HP:0007149)	1.90356686
79	Upper limb amyotrophy (HP:0009129)	1.90356686
80	Broad-based gait (HP:0002136)	1.90240611
81	Hepatic necrosis (HP:0002605)	1.88989708
82	Cerebral hypomyelination (HP:0006808)	1.88496198
83	Hepatocellular necrosis (HP:0001404)	1.86264365
84	Abnormality of glycine metabolism (HP:0010895)	1.84977749
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.84977749
86	Limb-girdle muscle weakness (HP:0003325)	1.84781331
87	Abnormality of glycolysis (HP:0004366)	1.83490063
88	Intestinal atresia (HP:0011100)	1.82686060
89	Tongue fasciculations (HP:0001308)	1.81930188
90	Spastic paraplegia (HP:0001258)	1.81525724
91	Progressive macrocephaly (HP:0004481)	1.81494815
92	Thyroid-stimulating hormone excess (HP:0002925)	1.81054535
93	Limb-girdle muscle atrophy (HP:0003797)	1.80631929
94	Keratoconus (HP:0000563)	1.79865553
95	Increased corneal curvature (HP:0100692)	1.79865553
96	Delusions (HP:0000746)	1.79272784
97	Epileptic encephalopathy (HP:0200134)	1.79137006
98	Broad foot (HP:0001769)	1.78964013
99	Progressive cerebellar ataxia (HP:0002073)	1.78599594
100	Pancreatic fibrosis (HP:0100732)	1.77620897

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCR	4.46608867
2	MAP3K4	3.92667522
3	MAP2K7	3.85409295
4	MARK1	3.72614011
5	TRIM28	3.55130967
6	MAP4K2	3.20680968
7	CASK	2.76075209
8	WNK3	2.70654594
9	EPHA3	2.58955802
10	DYRK2	2.47477857
11	CSNK1G3	2.34519338
12	SRPK1	2.28841541
13	CSNK1A1L	2.26638589
14	CSNK1G2	2.14252559
15	ERBB3	1.98340852
16	LIMK1	1.98053555
17	TESK1	1.97770066
18	BCKDK	1.92252717
19	MAP2K4	1.91854294
20	CSNK1G1	1.89340934
21	MAP3K12	1.76268601
22	MAPK13	1.72297419
23	SIK3	1.59922547
24	TSSK6	1.56088214
25	RPS6KA4	1.49486449
26	SIK2	1.27105503
27	DYRK3	1.27018814
28	PINK1	1.23724446
29	TESK2	1.20877106
30	MAP3K6	1.17306450
31	PAK6	1.16023399
32	CDK19	1.14228028
33	DYRK1B	1.09973252
34	NTRK2	1.09111128
35	PLK2	1.08706828
36	EPHA4	1.08350022
37	KSR1	1.06909346
38	MINK1	1.06201575
39	MAP3K5	1.03308711
40	UHMK1	1.01698337
41	BMPR1B	0.96392765
42	PIM2	0.95057879
43	EPHB1	0.93742660
44	PAK3	0.92926487
45	MAP3K11	0.90225243
46	CDK14	0.90034859
47	PRKCE	0.88549920
48	STK38L	0.79017215
49	PRKCG	0.77833576
50	EPHB2	0.77111665
51	CDK5	0.73911721
52	CDK18	0.73879039
53	RPS6KA5	0.70712584
54	DYRK1A	0.66473346
55	CDK15	0.61769777
56	CDK11A	0.61131510
57	CAMK2B	0.60799369
58	PDK2	0.59315297
59	DAPK2	0.58647530
60	FRK	0.56796602
61	PRKCZ	0.54521744
62	ADRBK2	0.53840120
63	NTRK1	0.52122714
64	FER	0.49540298
65	STK16	0.49036160
66	MAPKAPK5	0.48748089
67	CAMK2A	0.48566930
68	LMTK2	0.48438802
69	FLT3	0.48210201
70	CSNK1A1	0.47853801
71	CAMKK2	0.44230596
72	VRK1	0.43178473
73	GRK1	0.41314293
74	CAMK2G	0.40111745
75	CCNB1	0.39638943
76	PRKAA1	0.39636276
77	PKN2	0.39492821
78	CSNK1D	0.37014200
79	ZAK	0.36851469
80	TAOK3	0.36792645
81	CDK8	0.34266962
82	MAPK9	0.33744777
83	CAMK4	0.32754083
84	TAOK1	0.31529070
85	ADRBK1	0.31470110
86	PHKG1	0.31062672
87	PHKG2	0.31062672
88	STK38	0.29535688
89	DAPK1	0.28673646
90	ERBB4	0.28214310
91	AURKA	0.27445522
92	NME1	0.27302500
93	OXSR1	0.27205731
94	INSRR	0.26907211
95	PRKACA	0.26470360
96	PRKACB	0.25233948
97	PKN1	0.23742086
98	NEK1	0.23363038
99	CSNK1E	0.20296626
100	CDK9	0.18816359

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.42117180
2	Nicotine addiction_Homo sapiens_hsa05033	3.25650798
3	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.65439457
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.60368548
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.49885915
6	GABAergic synapse_Homo sapiens_hsa04727	2.45837600
7	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.43975676
8	Steroid biosynthesis_Homo sapiens_hsa00100	2.27406129
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.25726922
10	Protein export_Homo sapiens_hsa03060	2.21826619
11	Butanoate metabolism_Homo sapiens_hsa00650	2.19816268
12	Vibrio cholerae infection_Homo sapiens_hsa05110	2.18804021
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.05932527
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.98955701
15	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.82436848
16	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.76219136
17	Parkinsons disease_Homo sapiens_hsa05012	1.76080453
18	Morphine addiction_Homo sapiens_hsa05032	1.66745603
19	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.61897345
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.61836496
21	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.61076194
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.60442664
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56566273
24	Taste transduction_Homo sapiens_hsa04742	1.42151453
25	Cocaine addiction_Homo sapiens_hsa05030	1.38937508
26	Fatty acid elongation_Homo sapiens_hsa00062	1.38719929
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.36322006
28	Basal transcription factors_Homo sapiens_hsa03022	1.33691367
29	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.27434934
30	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.26855097
31	Regulation of autophagy_Homo sapiens_hsa04140	1.24683865
32	Phototransduction_Homo sapiens_hsa04744	1.24090894
33	Huntingtons disease_Homo sapiens_hsa05016	1.15938167
34	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.14937434
35	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.14158796
36	RNA polymerase_Homo sapiens_hsa03020	1.08951025
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.05766851
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04893894
39	Glutamatergic synapse_Homo sapiens_hsa04724	1.04578235
40	Axon guidance_Homo sapiens_hsa04360	1.02852959
41	Circadian entrainment_Homo sapiens_hsa04713	1.01224377
42	Proteasome_Homo sapiens_hsa03050	1.00221619
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.94446761
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92221154
45	Cardiac muscle contraction_Homo sapiens_hsa04260	0.90348144
46	Gap junction_Homo sapiens_hsa04540	0.88381038
47	Spliceosome_Homo sapiens_hsa03040	0.86231298
48	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.85552316
49	Alzheimers disease_Homo sapiens_hsa05010	0.84056957
50	Amphetamine addiction_Homo sapiens_hsa05031	0.83068260
51	Alcoholism_Homo sapiens_hsa05034	0.81284119
52	Peroxisome_Homo sapiens_hsa04146	0.80587780
53	Shigellosis_Homo sapiens_hsa05131	0.77618638
54	Propanoate metabolism_Homo sapiens_hsa00640	0.77098252
55	Phagosome_Homo sapiens_hsa04145	0.76541173
56	Sulfur metabolism_Homo sapiens_hsa00920	0.74953398
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.70332423
58	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70022357
59	Selenocompound metabolism_Homo sapiens_hsa00450	0.69404135
60	Serotonergic synapse_Homo sapiens_hsa04726	0.68268437
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.68152280
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.67036091
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66006331
64	RNA degradation_Homo sapiens_hsa03018	0.65978332
65	Base excision repair_Homo sapiens_hsa03410	0.63584679
66	Oocyte meiosis_Homo sapiens_hsa04114	0.62195840
67	Long-term depression_Homo sapiens_hsa04730	0.61122031
68	RNA transport_Homo sapiens_hsa03013	0.60704293
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.59971580
70	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.56771879
71	Ether lipid metabolism_Homo sapiens_hsa00565	0.55206811
72	Olfactory transduction_Homo sapiens_hsa04740	0.54154849
73	Carbon metabolism_Homo sapiens_hsa01200	0.53967775
74	Metabolic pathways_Homo sapiens_hsa01100	0.53243437
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.51794251
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.51473299
77	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51390246
78	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.48819594
79	Sulfur relay system_Homo sapiens_hsa04122	0.45805376
80	Salmonella infection_Homo sapiens_hsa05132	0.45138590
81	AMPK signaling pathway_Homo sapiens_hsa04152	0.44482227
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.43902039
83	Cholinergic synapse_Homo sapiens_hsa04725	0.43829715
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42363032
85	Circadian rhythm_Homo sapiens_hsa04710	0.40323652
86	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.39247143
87	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.38252852
88	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.34421932
89	Insulin secretion_Homo sapiens_hsa04911	0.32536405
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.30031030
91	Tight junction_Homo sapiens_hsa04530	0.28304157
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.27960400
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.27398015
94	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.26708665
95	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.24767867
96	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23943456
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.22401737
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.22245461
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.22020971
100	Pyrimidine metabolism_Homo sapiens_hsa00240	0.21587891

TUBB2BP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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