TUBB2BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)7.65583791
2nucleobase catabolic process (GO:0046113)5.95799473
3positive regulation of mitochondrial fission (GO:0090141)5.67023870
4gamma-aminobutyric acid transport (GO:0015812)5.26422794
5establishment of mitochondrion localization (GO:0051654)4.67579711
6negative regulation of synaptic transmission, GABAergic (GO:0032229)4.25295187
7neuron cell-cell adhesion (GO:0007158)4.15696926
8negative regulation of oligodendrocyte differentiation (GO:0048715)3.93641534
9regulation of mitochondrial fission (GO:0090140)3.83174820
10protein localization to synapse (GO:0035418)3.80200654
11sequestering of actin monomers (GO:0042989)3.78974435
12synaptic vesicle exocytosis (GO:0016079)3.71880991
13de novo posttranslational protein folding (GO:0051084)3.65904589
14synapse assembly (GO:0007416)3.64872830
15calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.64463611
16postsynaptic membrane organization (GO:0001941)3.59406016
17presynaptic membrane assembly (GO:0097105)3.56357020
18vocalization behavior (GO:0071625)3.55391173
19glycosphingolipid biosynthetic process (GO:0006688)3.52470818
20regulation of feeding behavior (GO:0060259)3.50177197
21positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.48778641
22presynaptic membrane organization (GO:0097090)3.46178130
23negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.42696813
24behavioral response to nicotine (GO:0035095)3.36574388
25de novo protein folding (GO:0006458)3.34328977
26ribonucleoprotein complex disassembly (GO:0032988)3.33393297
27protein insertion into membrane (GO:0051205)3.29262263
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.28555293
29L-serine transport (GO:0015825)3.24015992
30hippocampus development (GO:0021766)3.18403025
31protein deneddylation (GO:0000338)3.16272511
32synaptic vesicle maturation (GO:0016188)3.15816460
33response to dietary excess (GO:0002021)3.14561147
34DNA integration (GO:0015074)3.12218709
35protein polyglutamylation (GO:0018095)3.11882833
36axonal fasciculation (GO:0007413)3.10173727
37cullin deneddylation (GO:0010388)3.08600731
38positive regulation of synapse assembly (GO:0051965)3.06509052
39cell migration in hindbrain (GO:0021535)3.03450493
40neurotransmitter secretion (GO:0007269)2.99490537
41protein localization to cilium (GO:0061512)2.97169560
42negative regulation of microtubule polymerization (GO:0031115)2.95997141
43energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.95680567
44ATP hydrolysis coupled proton transport (GO:0015991)2.95680567
45positive regulation of TOR signaling (GO:0032008)2.93952650
46regulation of development, heterochronic (GO:0040034)2.93205943
47neuron recognition (GO:0008038)2.88615825
48metallo-sulfur cluster assembly (GO:0031163)2.86741094
49iron-sulfur cluster assembly (GO:0016226)2.86741094
50L-methionine biosynthetic process (GO:0071265)2.82898395
51amino acid salvage (GO:0043102)2.82898395
52L-methionine salvage (GO:0071267)2.82898395
53regulation of cilium movement (GO:0003352)2.81941234
54neurotransmitter biosynthetic process (GO:0042136)2.79963425
55ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.78572718
56ubiquinone metabolic process (GO:0006743)2.75695313
57regulation of vesicle fusion (GO:0031338)2.74373381
58DNA damage response, detection of DNA damage (GO:0042769)2.73763152
59positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.73536566
60mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.73536566
61synaptic vesicle endocytosis (GO:0048488)2.73518058
62negative regulation of telomere maintenance (GO:0032205)2.72726716
63establishment of melanosome localization (GO:0032401)2.72707600
64glycine transport (GO:0015816)2.71622261
65peroxisome fission (GO:0016559)2.70573191
66regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70362597
67nonmotile primary cilium assembly (GO:0035058)2.70266070
68regulation of synapse structural plasticity (GO:0051823)2.69710821
69organelle disassembly (GO:1903008)2.68961180
70glutamate secretion (GO:0014047)2.68110188
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65293488
72regulation of oligodendrocyte differentiation (GO:0048713)2.65084327
73protein-cofactor linkage (GO:0018065)2.64874428
74establishment of vesicle localization (GO:0051650)2.63234341
75G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.62670922
76establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.62612075
77mitochondrion transport along microtubule (GO:0047497)2.62612075
78melanosome transport (GO:0032402)2.62490375
79dendritic spine morphogenesis (GO:0060997)2.61718327
80C4-dicarboxylate transport (GO:0015740)2.59793515
81auditory behavior (GO:0031223)2.59272319
82regulation of synaptic vesicle exocytosis (GO:2000300)2.56680960
83regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.55354156
84forebrain neuron differentiation (GO:0021879)2.54710665
85establishment of pigment granule localization (GO:0051905)2.53937717
86olfactory bulb development (GO:0021772)2.53883633
87establishment of synaptic vesicle localization (GO:0097480)2.53535852
88synaptic vesicle transport (GO:0048489)2.53535852
89water-soluble vitamin biosynthetic process (GO:0042364)2.53489877
90negative regulation of membrane potential (GO:0045837)2.52910330
91melanosome localization (GO:0032400)2.52435744
92cerebral cortex radially oriented cell migration (GO:0021799)2.51914974
93neuronal action potential propagation (GO:0019227)2.51903203
94head development (GO:0060322)2.50812532
95retinal cone cell development (GO:0046549)2.50617903
96synaptic transmission, glutamatergic (GO:0035249)2.49894500
97serine transport (GO:0032329)2.49882912
98regulation of short-term neuronal synaptic plasticity (GO:0048172)2.48784291
99base-excision repair, AP site formation (GO:0006285)2.48148006
100peptidyl-arginine omega-N-methylation (GO:0035247)2.46953566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.77447343
2ZNF274_21170338_ChIP-Seq_K562_Hela3.84970847
3IGF1R_20145208_ChIP-Seq_DFB_Human3.80572620
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.67862413
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.92092849
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.82269257
7TAF15_26573619_Chip-Seq_HEK293_Human2.73431341
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.66942864
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.56450967
10GBX2_23144817_ChIP-Seq_PC3_Human2.51817351
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.45467320
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41513315
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40235563
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.33888867
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.27003547
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26974968
17EZH2_22144423_ChIP-Seq_EOC_Human2.19038988
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02718875
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.99532682
20REST_18959480_ChIP-ChIP_MESCs_Mouse1.93132532
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92714842
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85544684
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.76567404
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74183358
25IRF1_19129219_ChIP-ChIP_H3396_Human1.70451317
26REST_21632747_ChIP-Seq_MESCs_Mouse1.70296532
27FUS_26573619_Chip-Seq_HEK293_Human1.69205770
28VDR_22108803_ChIP-Seq_LS180_Human1.67113299
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63464064
30GABP_19822575_ChIP-Seq_HepG2_Human1.60051767
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59916468
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58989515
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57978954
34P300_19829295_ChIP-Seq_ESCs_Human1.54407821
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.50772191
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50582025
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50551048
38RNF2_27304074_Chip-Seq_NSC_Mouse1.48588657
39ELK1_19687146_ChIP-ChIP_HELA_Human1.48410973
40VDR_23849224_ChIP-Seq_CD4+_Human1.42828637
41EWS_26573619_Chip-Seq_HEK293_Human1.42490665
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.41329666
43SOX2_16153702_ChIP-ChIP_HESCs_Human1.38938161
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38336482
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35334981
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35133992
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34600729
48CBP_20019798_ChIP-Seq_JUKART_Human1.34600729
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32798708
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31378623
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.30312647
52DCP1A_22483619_ChIP-Seq_HELA_Human1.24951286
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23873697
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.21242114
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.17159764
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.16369616
57CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.14045737
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13494914
59KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11978039
60TP53_22573176_ChIP-Seq_HFKS_Human1.09904028
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09133729
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08910415
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08149955
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.06313707
65MYC_18940864_ChIP-ChIP_HL60_Human1.05024675
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02892001
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.02671067
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01488570
69JUN_21703547_ChIP-Seq_K562_Human1.01363892
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.01359618
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00736978
72SMAD4_21799915_ChIP-Seq_A2780_Human1.00054557
73ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98587563
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97687978
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97012125
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94158885
77SALL1_21062744_ChIP-ChIP_HESCs_Human0.93410186
78CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92905241
79GATA1_26923725_Chip-Seq_HPCs_Mouse0.92651005
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89815922
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89788703
82PIAS1_25552417_ChIP-Seq_VCAP_Human0.89550204
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88918062
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88594785
85REST_19997604_ChIP-ChIP_NEURONS_Mouse0.88565897
86AR_25329375_ChIP-Seq_VCAP_Human0.88221232
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88187194
88NANOG_16153702_ChIP-ChIP_HESCs_Human0.87848035
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87610676
90STAT3_23295773_ChIP-Seq_U87_Human0.86309559
91TAL1_26923725_Chip-Seq_HPCs_Mouse0.85727497
92SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85115793
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83770825
94EZH2_27304074_Chip-Seq_ESCs_Mouse0.83107451
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83077476
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82914320
97NELFA_20434984_ChIP-Seq_ESCs_Mouse0.82716891
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82665116
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81626225
100FOXP3_21729870_ChIP-Seq_TREG_Human0.81608532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.89899448
2MP0002822_catalepsy3.63657530
3MP0001529_abnormal_vocalization3.48770968
4MP0008789_abnormal_olfactory_epithelium2.97046989
5MP0004859_abnormal_synaptic_plasticity2.95321412
6MP0001984_abnormal_olfaction2.93177134
7MP0004270_analgesia2.92452753
8MP0005394_taste/olfaction_phenotype2.91963416
9MP0005499_abnormal_olfactory_system2.91963416
10MP0003122_maternal_imprinting2.78595452
11MP0000778_abnormal_nervous_system2.35515960
12MP0006276_abnormal_autonomic_nervous2.32055731
13MP0002736_abnormal_nociception_after2.30830805
14MP0003221_abnormal_cardiomyocyte_apopto2.19712061
15MP0003880_abnormal_central_pattern2.10094449
16MP0003635_abnormal_synaptic_transmissio2.05694636
17MP0000049_abnormal_middle_ear2.03446086
18MP0009046_muscle_twitch1.99320319
19MP0001968_abnormal_touch/_nociception1.87829589
20MP0002735_abnormal_chemical_nociception1.82956971
21MP0002063_abnormal_learning/memory/cond1.78185678
22MP0002572_abnormal_emotion/affect_behav1.73611979
23MP0003121_genomic_imprinting1.72468170
24MP0009745_abnormal_behavioral_response1.71916836
25MP0005645_abnormal_hypothalamus_physiol1.70523886
26MP0002653_abnormal_ependyma_morphology1.69175150
27MP0004811_abnormal_neuron_physiology1.66594482
28MP0005360_urolithiasis1.66204403
29MP0003011_delayed_dark_adaptation1.60492599
30MP0004142_abnormal_muscle_tone1.57745622
31MP0001486_abnormal_startle_reflex1.55457810
32MP0002557_abnormal_social/conspecific_i1.55202584
33MP0002064_seizures1.53614683
34MP0002272_abnormal_nervous_system1.52813028
35MP0001270_distended_abdomen1.50068610
36MP0005253_abnormal_eye_physiology1.49290028
37MP0001188_hyperpigmentation1.48891242
38MP0002734_abnormal_mechanical_nocicepti1.47722867
39MP0002751_abnormal_autonomic_nervous1.47600110
40MP0006072_abnormal_retinal_apoptosis1.47480258
41MP0001905_abnormal_dopamine_level1.43878578
42MP0002638_abnormal_pupillary_reflex1.37222652
43MP0003938_abnormal_ear_development1.30509512
44MP0002882_abnormal_neuron_morphology1.29958592
45MP0005386_behavior/neurological_phenoty1.26693016
46MP0004924_abnormal_behavior1.26693016
47MP0002733_abnormal_thermal_nociception1.25865711
48MP0002234_abnormal_pharynx_morphology1.25678110
49MP0000955_abnormal_spinal_cord1.24562456
50MP0002909_abnormal_adrenal_gland1.23529438
51MP0005084_abnormal_gallbladder_morpholo1.22593937
52MP0002184_abnormal_innervation1.21647250
53MP0001502_abnormal_circadian_rhythm1.20827704
54MP0001970_abnormal_pain_threshold1.19544283
55MP0004133_heterotaxia1.18495244
56MP0003890_abnormal_embryonic-extraembry1.16165296
57MP0002837_dystrophic_cardiac_calcinosis1.15956539
58MP0002067_abnormal_sensory_capabilities1.15654066
59MP0008877_abnormal_DNA_methylation1.09922954
60MP0002233_abnormal_nose_morphology1.09852149
61MP0002752_abnormal_somatic_nervous1.08519818
62MP0002069_abnormal_eating/drinking_beha1.08067580
63MP0005423_abnormal_somatic_nervous1.07325834
64MP0003787_abnormal_imprinting1.06134730
65MP0000026_abnormal_inner_ear1.01976720
66MP0000751_myopathy1.00715720
67MP0002152_abnormal_brain_morphology0.99062100
68MP0002066_abnormal_motor_capabilities/c0.98769879
69MP0000013_abnormal_adipose_tissue0.97033745
70MP0000631_abnormal_neuroendocrine_gland0.95903661
71MP0008995_early_reproductive_senescence0.95029237
72MP0004885_abnormal_endolymph0.94482991
73MP0005551_abnormal_eye_electrophysiolog0.94473039
74MP0005187_abnormal_penis_morphology0.93585544
75MP0001986_abnormal_taste_sensitivity0.91114949
76MP0005646_abnormal_pituitary_gland0.89471487
77MP0003567_abnormal_fetal_cardiomyocyte0.88146020
78MP0004742_abnormal_vestibular_system0.87367554
79MP0003329_amyloid_beta_deposits0.86389302
80MP0003861_abnormal_nervous_system0.86276727
81MP0003755_abnormal_palate_morphology0.86154397
82MP0004147_increased_porphyrin_level0.85636446
83MP0000647_abnormal_sebaceous_gland0.85402891
84MP0003137_abnormal_impulse_conducting0.85396652
85MP0003937_abnormal_limbs/digits/tail_de0.83923658
86MP0006292_abnormal_olfactory_placode0.78254805
87MP0006035_abnormal_mitochondrial_morpho0.76781724
88MP0003119_abnormal_digestive_system0.76710243
89MP0005391_vision/eye_phenotype0.75559388
90MP0004043_abnormal_pH_regulation0.74692875
91MP0001299_abnormal_eye_distance/0.74608149
92MP0005623_abnormal_meninges_morphology0.73703257
93MP0002177_abnormal_outer_ear0.69311994
94MP0003385_abnormal_body_wall0.69132818
95MP0002229_neurodegeneration0.68814461
96MP0005195_abnormal_posterior_eye0.67905867
97MP0002249_abnormal_larynx_morphology0.67042907
98MP0001440_abnormal_grooming_behavior0.66739827
99MP0002332_abnormal_exercise_endurance0.66290337
100MP0005248_abnormal_Harderian_gland0.65915201

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.99455409
2Polyphagia (HP:0002591)3.52768346
3Shoulder girdle muscle weakness (HP:0003547)3.49667544
4Lissencephaly (HP:0001339)3.49176171
5Split foot (HP:0001839)3.41755940
6Pachygyria (HP:0001302)3.37408094
7Hypoplasia of the brainstem (HP:0002365)3.30214083
8Aplasia/Hypoplasia of the brainstem (HP:0007362)3.30214083
9Retinal dysplasia (HP:0007973)3.28658257
10Drooling (HP:0002307)3.28291580
11Amyotrophic lateral sclerosis (HP:0007354)3.25467109
12Abnormality of the musculature of the pelvis (HP:0001469)3.20090548
13Abnormality of the hip-girdle musculature (HP:0001445)3.20090548
14Hyperglycinemia (HP:0002154)3.11608017
15Poor suck (HP:0002033)3.03811000
16Upper limb muscle weakness (HP:0003484)3.00285669
17Excessive salivation (HP:0003781)2.98675587
18Gait imbalance (HP:0002141)2.92047282
19Failure to thrive in infancy (HP:0001531)2.88393898
20Abnormality of the labia minora (HP:0012880)2.86684286
21Limb dystonia (HP:0002451)2.84355867
22Urinary urgency (HP:0000012)2.83995546
23Hand muscle atrophy (HP:0009130)2.81231169
24Medial flaring of the eyebrow (HP:0010747)2.80460428
25Nephrogenic diabetes insipidus (HP:0009806)2.74906937
26Spastic gait (HP:0002064)2.74510610
27Pelvic girdle muscle weakness (HP:0003749)2.70341393
28Congenital primary aphakia (HP:0007707)2.70109757
29Ankle clonus (HP:0011448)2.70038388
30Atrophy/Degeneration involving motor neurons (HP:0007373)2.67160331
31Specific learning disability (HP:0001328)2.53807267
32Absent speech (HP:0001344)2.48036915
33Pendular nystagmus (HP:0012043)2.46929630
34Esotropia (HP:0000565)2.45196583
35Polymicrogyria (HP:0002126)2.45007473
36Abnormality of the lower motor neuron (HP:0002366)2.44860962
37Hypsarrhythmia (HP:0002521)2.44833267
38Hemiparesis (HP:0001269)2.43378649
39Abnormality of the corticospinal tract (HP:0002492)2.41970106
40Spastic tetraplegia (HP:0002510)2.41472757
41Progressive inability to walk (HP:0002505)2.40987580
42Lower limb muscle weakness (HP:0007340)2.38618353
43Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.37100889
44EEG with generalized epileptiform discharges (HP:0011198)2.33483418
45Wrist flexion contracture (HP:0001239)2.28292957
46Rimmed vacuoles (HP:0003805)2.26933685
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24927025
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.24927025
49Epileptiform EEG discharges (HP:0011182)2.23556810
50CNS hypomyelination (HP:0003429)2.19411153
51Abnormality of alanine metabolism (HP:0010916)2.13736441
52Hyperalaninemia (HP:0003348)2.13736441
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13736441
54Amblyopia (HP:0000646)2.12542332
55Impaired vibration sensation in the lower limbs (HP:0002166)2.11401584
56Type II lissencephaly (HP:0007260)2.11218139
57Acute necrotizing encephalopathy (HP:0006965)2.11048852
58Hypoplasia of the corpus callosum (HP:0002079)2.10911721
59Paraplegia (HP:0010550)2.10619868
60Increased serum pyruvate (HP:0003542)2.10557975
61Inability to walk (HP:0002540)2.10544015
62Mutism (HP:0002300)2.09843159
63Muscular hypotonia of the trunk (HP:0008936)2.09589715
64Peripheral hypomyelination (HP:0007182)2.09226006
65Abnormality of the metopic suture (HP:0005556)2.06580179
66Myokymia (HP:0002411)2.05910927
67Abnormal mitochondria in muscle tissue (HP:0008316)2.04728822
68Abnormal eating behavior (HP:0100738)2.02645742
69Severe muscular hypotonia (HP:0006829)2.01975124
70Pancreatic cysts (HP:0001737)2.01777177
71Increased CSF lactate (HP:0002490)1.99541683
72Methylmalonic acidemia (HP:0002912)1.97626639
73Vaginal atresia (HP:0000148)1.94422781
74Genital tract atresia (HP:0001827)1.94260951
75True hermaphroditism (HP:0010459)1.92917554
76Autoamputation (HP:0001218)1.92787817
77Acute encephalopathy (HP:0006846)1.91930525
78Distal upper limb amyotrophy (HP:0007149)1.90356686
79Upper limb amyotrophy (HP:0009129)1.90356686
80Broad-based gait (HP:0002136)1.90240611
81Hepatic necrosis (HP:0002605)1.88989708
82Cerebral hypomyelination (HP:0006808)1.88496198
83Hepatocellular necrosis (HP:0001404)1.86264365
84Abnormality of serine family amino acid metabolism (HP:0010894)1.84977749
85Abnormality of glycine metabolism (HP:0010895)1.84977749
86Limb-girdle muscle weakness (HP:0003325)1.84781331
87Abnormality of glycolysis (HP:0004366)1.83490063
88Intestinal atresia (HP:0011100)1.82686060
89Tongue fasciculations (HP:0001308)1.81930188
90Spastic paraplegia (HP:0001258)1.81525724
91Progressive macrocephaly (HP:0004481)1.81494815
92Thyroid-stimulating hormone excess (HP:0002925)1.81054535
93Limb-girdle muscle atrophy (HP:0003797)1.80631929
94Keratoconus (HP:0000563)1.79865553
95Increased corneal curvature (HP:0100692)1.79865553
96Delusions (HP:0000746)1.79272784
97Epileptic encephalopathy (HP:0200134)1.79137006
98Broad foot (HP:0001769)1.78964013
99Progressive cerebellar ataxia (HP:0002073)1.78599594
100Pancreatic fibrosis (HP:0100732)1.77620897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCR4.46608867
2MAP3K43.92667522
3MAP2K73.85409295
4MARK13.72614011
5TRIM283.55130967
6MAP4K23.20680968
7CASK2.76075209
8WNK32.70654594
9EPHA32.58955802
10DYRK22.47477857
11CSNK1G32.34519338
12SRPK12.28841541
13CSNK1A1L2.26638589
14CSNK1G22.14252559
15ERBB31.98340852
16LIMK11.98053555
17TESK11.97770066
18BCKDK1.92252717
19MAP2K41.91854294
20CSNK1G11.89340934
21MAP3K121.76268601
22MAPK131.72297419
23SIK31.59922547
24TSSK61.56088214
25RPS6KA41.49486449
26SIK21.27105503
27DYRK31.27018814
28PINK11.23724446
29TESK21.20877106
30MAP3K61.17306450
31PAK61.16023399
32CDK191.14228028
33DYRK1B1.09973252
34NTRK21.09111128
35PLK21.08706828
36EPHA41.08350022
37KSR11.06909346
38MINK11.06201575
39MAP3K51.03308711
40UHMK11.01698337
41BMPR1B0.96392765
42PIM20.95057879
43EPHB10.93742660
44PAK30.92926487
45MAP3K110.90225243
46CDK140.90034859
47PRKCE0.88549920
48STK38L0.79017215
49PRKCG0.77833576
50EPHB20.77111665
51CDK50.73911721
52CDK180.73879039
53RPS6KA50.70712584
54DYRK1A0.66473346
55CDK150.61769777
56CDK11A0.61131510
57CAMK2B0.60799369
58PDK20.59315297
59DAPK20.58647530
60FRK0.56796602
61PRKCZ0.54521744
62ADRBK20.53840120
63NTRK10.52122714
64FER0.49540298
65STK160.49036160
66MAPKAPK50.48748089
67CAMK2A0.48566930
68LMTK20.48438802
69FLT30.48210201
70CSNK1A10.47853801
71CAMKK20.44230596
72VRK10.43178473
73GRK10.41314293
74CAMK2G0.40111745
75CCNB10.39638943
76PRKAA10.39636276
77PKN20.39492821
78CSNK1D0.37014200
79ZAK0.36851469
80TAOK30.36792645
81CDK80.34266962
82MAPK90.33744777
83CAMK40.32754083
84TAOK10.31529070
85ADRBK10.31470110
86PHKG10.31062672
87PHKG20.31062672
88STK380.29535688
89DAPK10.28673646
90ERBB40.28214310
91AURKA0.27445522
92NME10.27302500
93OXSR10.27205731
94INSRR0.26907211
95PRKACA0.26470360
96PRKACB0.25233948
97PKN10.23742086
98NEK10.23363038
99CSNK1E0.20296626
100CDK90.18816359

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.42117180
2Nicotine addiction_Homo sapiens_hsa050333.25650798
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.65439457
4Synaptic vesicle cycle_Homo sapiens_hsa047212.60368548
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49885915
6GABAergic synapse_Homo sapiens_hsa047272.45837600
7Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.43975676
8Steroid biosynthesis_Homo sapiens_hsa001002.27406129
9Collecting duct acid secretion_Homo sapiens_hsa049662.25726922
10Protein export_Homo sapiens_hsa030602.21826619
11Butanoate metabolism_Homo sapiens_hsa006502.19816268
12Vibrio cholerae infection_Homo sapiens_hsa051102.18804021
13Oxidative phosphorylation_Homo sapiens_hsa001902.05932527
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98955701
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82436848
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76219136
17Parkinsons disease_Homo sapiens_hsa050121.76080453
18Morphine addiction_Homo sapiens_hsa050321.66745603
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.61897345
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61836496
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61076194
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60442664
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56566273
24Taste transduction_Homo sapiens_hsa047421.42151453
25Cocaine addiction_Homo sapiens_hsa050301.38937508
26Fatty acid elongation_Homo sapiens_hsa000621.38719929
27Dopaminergic synapse_Homo sapiens_hsa047281.36322006
28Basal transcription factors_Homo sapiens_hsa030221.33691367
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27434934
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.26855097
31Regulation of autophagy_Homo sapiens_hsa041401.24683865
32Phototransduction_Homo sapiens_hsa047441.24090894
33Huntingtons disease_Homo sapiens_hsa050161.15938167
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14937434
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14158796
36RNA polymerase_Homo sapiens_hsa030201.08951025
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05766851
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04893894
39Glutamatergic synapse_Homo sapiens_hsa047241.04578235
40Axon guidance_Homo sapiens_hsa043601.02852959
41Circadian entrainment_Homo sapiens_hsa047131.01224377
42Proteasome_Homo sapiens_hsa030501.00221619
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94446761
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92221154
45Cardiac muscle contraction_Homo sapiens_hsa042600.90348144
46Gap junction_Homo sapiens_hsa045400.88381038
47Spliceosome_Homo sapiens_hsa030400.86231298
48Biosynthesis of amino acids_Homo sapiens_hsa012300.85552316
49Alzheimers disease_Homo sapiens_hsa050100.84056957
50Amphetamine addiction_Homo sapiens_hsa050310.83068260
51Alcoholism_Homo sapiens_hsa050340.81284119
52Peroxisome_Homo sapiens_hsa041460.80587780
53Shigellosis_Homo sapiens_hsa051310.77618638
54Propanoate metabolism_Homo sapiens_hsa006400.77098252
55Phagosome_Homo sapiens_hsa041450.76541173
56Sulfur metabolism_Homo sapiens_hsa009200.74953398
57Fatty acid metabolism_Homo sapiens_hsa012120.70332423
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70022357
59Selenocompound metabolism_Homo sapiens_hsa004500.69404135
60Serotonergic synapse_Homo sapiens_hsa047260.68268437
61Arginine and proline metabolism_Homo sapiens_hsa003300.68152280
62beta-Alanine metabolism_Homo sapiens_hsa004100.67036091
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66006331
64RNA degradation_Homo sapiens_hsa030180.65978332
65Base excision repair_Homo sapiens_hsa034100.63584679
66Oocyte meiosis_Homo sapiens_hsa041140.62195840
67Long-term depression_Homo sapiens_hsa047300.61122031
68RNA transport_Homo sapiens_hsa030130.60704293
69mRNA surveillance pathway_Homo sapiens_hsa030150.59971580
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56771879
71Ether lipid metabolism_Homo sapiens_hsa005650.55206811
72Olfactory transduction_Homo sapiens_hsa047400.54154849
73Carbon metabolism_Homo sapiens_hsa012000.53967775
74Metabolic pathways_Homo sapiens_hsa011000.53243437
75Tryptophan metabolism_Homo sapiens_hsa003800.51794251
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51473299
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51390246
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48819594
79Sulfur relay system_Homo sapiens_hsa041220.45805376
80Salmonella infection_Homo sapiens_hsa051320.45138590
81AMPK signaling pathway_Homo sapiens_hsa041520.44482227
82Hippo signaling pathway_Homo sapiens_hsa043900.43902039
83Cholinergic synapse_Homo sapiens_hsa047250.43829715
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42363032
85Circadian rhythm_Homo sapiens_hsa047100.40323652
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39247143
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38252852
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34421932
89Insulin secretion_Homo sapiens_hsa049110.32536405
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.30031030
91Tight junction_Homo sapiens_hsa045300.28304157
92Pyruvate metabolism_Homo sapiens_hsa006200.27960400
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27398015
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26708665
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24767867
96Linoleic acid metabolism_Homo sapiens_hsa005910.23943456
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.22401737
98Hedgehog signaling pathway_Homo sapiens_hsa043400.22245461
99Fat digestion and absorption_Homo sapiens_hsa049750.22020971
100Pyrimidine metabolism_Homo sapiens_hsa002400.21587891

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »