TUBB4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)5.87374128
2Golgi transport vesicle coating (GO:0048200)4.82215813
3COPI coating of Golgi vesicle (GO:0048205)4.82215813
4protein localization to kinetochore (GO:0034501)4.72467157
5cilium movement (GO:0003341)4.49478840
6DNA strand elongation involved in DNA replication (GO:0006271)4.48920471
7protein localization to chromosome, centromeric region (GO:0071459)4.46685399
8DNA unwinding involved in DNA replication (GO:0006268)4.42640093
9DNA replication initiation (GO:0006270)4.38961342
10mitotic metaphase plate congression (GO:0007080)4.30241426
11mitotic sister chromatid segregation (GO:0000070)4.28332701
12DNA strand elongation (GO:0022616)4.21020689
13mitotic nuclear envelope disassembly (GO:0007077)4.09104671
14mitotic chromosome condensation (GO:0007076)4.07517286
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.04406423
16DNA replication-dependent nucleosome assembly (GO:0006335)4.03135822
17DNA replication-dependent nucleosome organization (GO:0034723)4.03135822
18telomere maintenance via semi-conservative replication (GO:0032201)4.01580312
19proline biosynthetic process (GO:0006561)3.91314773
20membrane disassembly (GO:0030397)3.88571491
21nuclear envelope disassembly (GO:0051081)3.88571491
22formation of translation preinitiation complex (GO:0001731)3.83430301
23piRNA metabolic process (GO:0034587)3.82733198
24sister chromatid segregation (GO:0000819)3.80280402
25metaphase plate congression (GO:0051310)3.78422971
26left/right pattern formation (GO:0060972)3.78215626
27regulation of spindle organization (GO:0090224)3.75061004
28protein maturation by protein folding (GO:0022417)3.71586355
29chromatin remodeling at centromere (GO:0031055)3.70600609
30microtubule depolymerization (GO:0007019)3.69578022
31attachment of spindle microtubules to kinetochore (GO:0008608)3.67100388
32DNA replication checkpoint (GO:0000076)3.64857468
33establishment of apical/basal cell polarity (GO:0035089)3.61344242
34nucleobase biosynthetic process (GO:0046112)3.59858773
35DNA deamination (GO:0045006)3.58261823
36CENP-A containing nucleosome assembly (GO:0034080)3.57784188
37establishment of chromosome localization (GO:0051303)3.48480225
38epithelial cilium movement (GO:0003351)3.48157879
39histone exchange (GO:0043486)3.47892496
40establishment of integrated proviral latency (GO:0075713)3.47578219
41nuclear pore organization (GO:0006999)3.47347594
42telomere maintenance via recombination (GO:0000722)3.45958488
43folic acid-containing compound biosynthetic process (GO:0009396)3.44996706
44maturation of SSU-rRNA (GO:0030490)3.43764167
45nuclear envelope reassembly (GO:0031468)3.43572670
46mitotic nuclear envelope reassembly (GO:0007084)3.43572670
47protein complex localization (GO:0031503)3.42398252
48mitotic recombination (GO:0006312)3.41828849
49nucleobase-containing small molecule interconversion (GO:0015949)3.41791914
50regulation of translational termination (GO:0006449)3.41118406
51regulation of chromosome segregation (GO:0051983)3.40388925
52synaptonemal complex assembly (GO:0007130)3.36930109
53DNA replication-independent nucleosome organization (GO:0034724)3.36878406
54DNA replication-independent nucleosome assembly (GO:0006336)3.36878406
55chromosome condensation (GO:0030261)3.36226895
56binding of sperm to zona pellucida (GO:0007339)3.35554124
57axonemal dynein complex assembly (GO:0070286)3.34352929
58positive regulation of chromosome segregation (GO:0051984)3.32473819
59purine nucleobase biosynthetic process (GO:0009113)3.31588574
60synaptonemal complex organization (GO:0070193)3.31116181
61maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31110533
62protein retention in ER lumen (GO:0006621)3.30177534
63regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.29331976
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25847050
65nuclear pore complex assembly (GO:0051292)3.24181052
66primary alcohol catabolic process (GO:0034310)3.22122826
67negative regulation of chromosome segregation (GO:0051985)3.20994866
68protein localization to chromosome (GO:0034502)3.20297190
69IMP biosynthetic process (GO:0006188)3.19169003
70ribosome assembly (GO:0042255)3.17867950
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.17602108
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.15355242
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15355242
74negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15355242
75negative regulation of sister chromatid segregation (GO:0033046)3.15355242
76ribosome biogenesis (GO:0042254)3.14665896
77telomere maintenance via telomere lengthening (GO:0010833)3.13415367
78chaperone-mediated protein complex assembly (GO:0051131)3.12309611
79desmosome organization (GO:0002934)3.12248790
80negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.10994135
81regulation of centrosome cycle (GO:0046605)3.09963127
82kinetochore organization (GO:0051383)3.08919678
83nuclear envelope organization (GO:0006998)3.08481794
84spindle checkpoint (GO:0031577)3.08129583
85mitotic spindle assembly checkpoint (GO:0007094)3.06306250
86spindle assembly checkpoint (GO:0071173)3.06143212
87regulation of histone H3-K9 methylation (GO:0051570)3.05222832
88translesion synthesis (GO:0019985)3.04864230
89translational elongation (GO:0006414)3.04708804
90viral transcription (GO:0019083)3.04426255
91regulation of mitotic spindle organization (GO:0060236)3.03295395
92translational termination (GO:0006415)3.02953427
93DNA packaging (GO:0006323)3.02858014
94male meiosis (GO:0007140)3.02290170
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01230952
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.00437312
97ribosomal large subunit biogenesis (GO:0042273)3.00121523
98ribosomal small subunit assembly (GO:0000028)2.99707912
99cilium or flagellum-dependent cell motility (GO:0001539)2.96987093
100pentose-phosphate shunt (GO:0006098)2.96378593
101translational initiation (GO:0006413)2.96299373
102chromatin assembly or disassembly (GO:0006333)2.94432764
103IMP metabolic process (GO:0046040)2.94159237
104sperm-egg recognition (GO:0035036)2.94038614
105regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93975957
106postreplication repair (GO:0006301)2.93965235
107ventricular cardiac muscle cell development (GO:0055015)2.93763991
108epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93657047
109mitotic spindle checkpoint (GO:0071174)2.93400339
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92122525
111vitamin transmembrane transport (GO:0035461)2.91916282
112negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.91794829
113ribonucleoprotein complex biogenesis (GO:0022613)2.91405040
114regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91091903
115UTP biosynthetic process (GO:0006228)2.90570836
116meiotic nuclear division (GO:0007126)2.90314917
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.89723325
118DNA duplex unwinding (GO:0032508)2.89151903
119spliceosomal snRNP assembly (GO:0000387)2.88094835
120chromosome segregation (GO:0007059)2.87961801
121cellular protein complex localization (GO:0034629)2.87648523
122heterochromatin organization (GO:0070828)2.86641394
123DNA geometric change (GO:0032392)2.86407592
124establishment of viral latency (GO:0019043)2.85698214
125diterpenoid biosynthetic process (GO:0016102)2.83926598
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.83059803
127* mitotic cell cycle (GO:0000278)2.82657597
128protein K6-linked ubiquitination (GO:0085020)2.82641920
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.77257408
130DNA topological change (GO:0006265)2.75841823
131establishment or maintenance of monopolar cell polarity (GO:0061339)2.72419143
132establishment of monopolar cell polarity (GO:0061162)2.72419143
133lung epithelium development (GO:0060428)2.69244823
134regulation of translational fidelity (GO:0006450)2.66970749
135glucose catabolic process (GO:0006007)2.66890918
136NADPH regeneration (GO:0006740)2.64757342
137peptidyl-arginine omega-N-methylation (GO:0035247)2.63399032
138proline metabolic process (GO:0006560)2.60529228
139mitotic cytokinesis (GO:0000281)2.60159071
140mitotic G1 DNA damage checkpoint (GO:0031571)2.59729753
141activation of Rac GTPase activity (GO:0032863)2.57241420
142negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.56337460
143DNA ligation (GO:0006266)2.55720693
144negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54537001
145microtubule polymerization or depolymerization (GO:0031109)2.51798590
146regulation of microtubule depolymerization (GO:0031114)2.50254478
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48868675
148epithelial cell-cell adhesion (GO:0090136)2.48815178
149negative regulation of microtubule depolymerization (GO:0007026)2.47716188
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47593142
151GDP-mannose metabolic process (GO:0019673)2.46829064
152protein depolymerization (GO:0051261)2.44742894
153regulation of sister chromatid cohesion (GO:0007063)2.40323633
154pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.39180429
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.39074361
156glomerular epithelial cell development (GO:0072310)2.35052361
157deoxyribonucleotide biosynthetic process (GO:0009263)2.34520869
158spindle assembly involved in mitosis (GO:0090307)2.33922942
159maternal placenta development (GO:0001893)2.33302084
160deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.31670934
161adherens junction assembly (GO:0034333)2.29959619
162positive regulation of cytokinesis (GO:0032467)2.26813913
163mitochondrial fusion (GO:0008053)2.26353941
164positive regulation of DNA-dependent DNA replication (GO:2000105)2.25807904

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.60068487
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.95337430
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.05006129
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.95013852
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.79160152
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37837303
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31489988
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.10925148
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.85627251
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.73045731
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.72201980
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56130161
13AR_21909140_ChIP-Seq_LNCAP_Human2.50443979
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.45966510
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42143470
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.40452905
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38128338
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30989284
19XRN2_22483619_ChIP-Seq_HELA_Human2.30654319
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26533435
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20039730
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.19641654
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19363706
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.92152014
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.92111826
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.91319346
27RACK7_27058665_Chip-Seq_MCF-7_Human1.85111172
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84570883
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83073281
30GABP_19822575_ChIP-Seq_HepG2_Human1.82016050
31DCP1A_22483619_ChIP-Seq_HELA_Human1.80980394
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78881039
33VDR_23849224_ChIP-Seq_CD4+_Human1.76761773
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76078293
35TTF2_22483619_ChIP-Seq_HELA_Human1.69528186
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68856805
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67976473
38PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.66465523
39LXR_22292898_ChIP-Seq_THP-1_Human1.65764527
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65556543
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.62510015
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.61813014
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61809993
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60192793
45FOXP3_21729870_ChIP-Seq_TREG_Human1.58294774
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57793694
47ZNF263_19887448_ChIP-Seq_K562_Human1.57769486
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54842578
49CLOCK_20551151_ChIP-Seq_293T_Human1.51529975
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50406966
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49843988
52MYC_22102868_ChIP-Seq_BL_Human1.47181192
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47166756
54CIITA_25753668_ChIP-Seq_RAJI_Human1.45708549
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45146035
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.44001996
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.43802932
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.42880766
59KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42672360
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42381907
61KDM5A_27292631_Chip-Seq_BREAST_Human1.40622154
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.39205049
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38412914
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34793702
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34600920
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33122417
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32343787
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31924845
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27441910
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.26270017
71NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.25953050
72KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24469044
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22951473
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.22153243
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21244648
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.18474887
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18378586
78P68_20966046_ChIP-Seq_HELA_Human1.17368563
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14395476
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13280361
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13279257
82SMC4_20622854_ChIP-Seq_HELA_Human1.12315382
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11721925
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11329167
85ESR2_21235772_ChIP-Seq_MCF-7_Human1.11304913
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10590441
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09557513
88ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09526610
89HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09220726
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09162955
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08510958
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06004362
93KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05530907
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04425152
95* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03709347
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03497422
97SRF_21415370_ChIP-Seq_HL-1_Mouse1.03179126
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02841421
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02217753
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01623636
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01533235
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00828728
103YY1_22570637_ChIP-Seq_MALME-3M_Human1.00381982
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99072764
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99044694
106VDR_21846776_ChIP-Seq_THP-1_Human0.98711348
107CHD1_26751641_Chip-Seq_LNCaP_Human0.97907268
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97230279
109CREB1_26743006_Chip-Seq_LNCaP_Human0.96678767
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94701982
111TP53_22127205_ChIP-Seq_IMR90_Human0.94594421
112SA1_27219007_Chip-Seq_ERYTHROID_Human0.94386822
113SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94321662
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94249469
115RUNX1_27514584_Chip-Seq_MCF-7_Human0.91930857
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91702003
117NCOR1_26117541_ChIP-Seq_K562_Human0.91681363
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91622296
119ATF3_27146783_Chip-Seq_COLON_Human0.91590243
120ELF1_20517297_ChIP-Seq_JURKAT_Human0.91128148
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89773842
122ELK1_19687146_ChIP-ChIP_HELA_Human0.89158364
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.88563516
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.87986700
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86741039
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86529382
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86466882
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85757761
129TFEB_21752829_ChIP-Seq_HELA_Human0.85707425
130FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85377455
131ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85192493
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84753106
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84050274
134ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82472489
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81706389
136OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81428820
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80940989
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.79742602
139ESR1_15608294_ChIP-ChIP_MCF-7_Human0.79475136
140CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77537778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.82909652
2MP0003111_abnormal_nucleus_morphology4.56268462
3MP0004957_abnormal_blastocyst_morpholog4.49108870
4MP0010094_abnormal_chromosome_stability4.38819802
5MP0003077_abnormal_cell_cycle3.85143623
6MP0008877_abnormal_DNA_methylation3.34141842
7MP0005623_abnormal_meninges_morphology3.01666074
8MP0008058_abnormal_DNA_repair2.91021011
9MP0008057_abnormal_DNA_replication2.83945503
10MP0005410_abnormal_fertilization2.75365289
11MP0008932_abnormal_embryonic_tissue2.68408713
12MP0001730_embryonic_growth_arrest2.65762543
13MP0002877_abnormal_melanocyte_morpholog2.60897281
14MP0008007_abnormal_cellular_replicative2.54876825
15MP0003123_paternal_imprinting2.37296702
16MP0010352_gastrointestinal_tract_polyps2.32678281
17MP0000566_synostosis2.29799974
18MP0000350_abnormal_cell_proliferation2.26881855
19MP0001929_abnormal_gametogenesis2.20929496
20MP0002210_abnormal_sex_determination2.11982671
21MP0003786_premature_aging2.06462148
22MP0002653_abnormal_ependyma_morphology2.06061109
23MP0003806_abnormal_nucleotide_metabolis1.89639272
24MP0010307_abnormal_tumor_latency1.85874891
25MP0001145_abnormal_male_reproductive1.82891008
26MP0010234_abnormal_vibrissa_follicle1.81678800
27MP0000678_abnormal_parathyroid_gland1.80760630
28MP0001346_abnormal_lacrimal_gland1.77284289
29MP0001697_abnormal_embryo_size1.73287724
30MP0003698_abnormal_male_reproductive1.73005076
31MP0000490_abnormal_crypts_of1.72071260
32MP0002080_prenatal_lethality1.71213586
33MP0003453_abnormal_keratinocyte_physiol1.68496396
34MP0008875_abnormal_xenobiotic_pharmacok1.66850215
35MP0005451_abnormal_body_composition1.66061450
36MP0004147_increased_porphyrin_level1.65265368
37MP0005380_embryogenesis_phenotype1.65075925
38MP0001672_abnormal_embryogenesis/_devel1.65075925
39MP0002160_abnormal_reproductive_system1.64136289
40MP0005377_hearing/vestibular/ear_phenot1.64038949
41MP0003878_abnormal_ear_physiology1.64038949
42MP0009780_abnormal_chondrocyte_physiolo1.60656457
43MP0000537_abnormal_urethra_morphology1.60541627
44MP0003718_maternal_effect1.60464053
45MP0000653_abnormal_sex_gland1.60381603
46MP0005257_abnormal_intraocular_pressure1.59168539
47MP0002085_abnormal_embryonic_tissue1.56044446
48MP0002084_abnormal_developmental_patter1.52375180
49MP0000579_abnormal_nail_morphology1.49101938
50MP0004272_abnormal_basement_membrane1.47252415
51MP0009379_abnormal_foot_pigmentation1.46763519
52MP0002060_abnormal_skin_morphology1.44675248
53MP0005397_hematopoietic_system_phenotyp1.44206920
54MP0001545_abnormal_hematopoietic_system1.44206920
55MP0003984_embryonic_growth_retardation1.42484930
56MP0003656_abnormal_erythrocyte_physiolo1.42174676
57MP0003950_abnormal_plasma_membrane1.41158869
58MP0000313_abnormal_cell_death1.37946419
59MP0002088_abnormal_embryonic_growth/wei1.37398622
60MP0000762_abnormal_tongue_morphology1.37143953
61MP0002019_abnormal_tumor_incidence1.36398947
62MP0004858_abnormal_nervous_system1.33709492
63MP0003941_abnormal_skin_development1.31620411
64MP0002086_abnormal_extraembryonic_tissu1.31211333
65MP0000467_abnormal_esophagus_morphology1.30956607
66MP0008260_abnormal_autophagy1.30765160
67MP0008438_abnormal_cutaneous_collagen1.27065331
68MP0004808_abnormal_hematopoietic_stem1.24338915
69MP0002396_abnormal_hematopoietic_system1.24104103
70MP0000358_abnormal_cell_content/1.24028647
71MP0002098_abnormal_vibrissa_morphology1.23133154
72MP0002161_abnormal_fertility/fecundity1.22373126
73MP0002249_abnormal_larynx_morphology1.21351137
74MP0004185_abnormal_adipocyte_glucose1.21133757
75MP0001216_abnormal_epidermal_layer1.18714355
76MP0004197_abnormal_fetal_growth/weight/1.17818670
77MP0006054_spinal_hemorrhage1.17623945
78MP0010030_abnormal_orbit_morphology1.16854197
79MP0005058_abnormal_lysosome_morphology1.16771293
80MP0005501_abnormal_skin_physiology1.14425696
81MP0001849_ear_inflammation1.14213566
82MP0006036_abnormal_mitochondrial_physio1.12002913
83MP0003315_abnormal_perineum_morphology1.11687676
84MP0000858_altered_metastatic_potential1.08584253
85MP0005409_darkened_coat_color1.08463416
86MP0003705_abnormal_hypodermis_morpholog1.05598961
87MP0005083_abnormal_biliary_tract1.04233364
88MP0004133_heterotaxia1.04097797
89MP0005389_reproductive_system_phenotype1.03958021
90MP0005076_abnormal_cell_differentiation1.01953788
91MP0010678_abnormal_skin_adnexa0.98343135
92MP0003566_abnormal_cell_adhesion0.98164267
93MP0000003_abnormal_adipose_tissue0.96797929
94MP0000733_abnormal_muscle_development0.93127874
95MP0002089_abnormal_postnatal_growth/wei0.92404805
96MP0010771_integument_phenotype0.92263304
97MP0006035_abnormal_mitochondrial_morpho0.90456738
98MP0002796_impaired_skin_barrier0.90037240
99MP0008995_early_reproductive_senescence0.89887923
100MP0000751_myopathy0.89660826
101MP0003942_abnormal_urinary_system0.89649184
102MP0004233_abnormal_muscle_weight0.87446468
103MP0003191_abnormal_cellular_cholesterol0.86652894
104MP0003091_abnormal_cell_migration0.85291272
105MP0003567_abnormal_fetal_cardiomyocyte0.84841023
106MP0004264_abnormal_extraembryonic_tissu0.84801576
107MP0003221_abnormal_cardiomyocyte_apopto0.84024769
108MP0001243_abnormal_dermal_layer0.83539352
109MP0005165_increased_susceptibility_to0.82936583
110MP0002092_abnormal_eye_morphology0.81644076
111MP0005499_abnormal_olfactory_system0.78778012
112MP0005394_taste/olfaction_phenotype0.78778012
113MP0000534_abnormal_ureter_morphology0.78233770
114MP0000477_abnormal_intestine_morphology0.78137269
115MP0005384_cellular_phenotype0.77598940
116MP0000627_abnormal_mammary_gland0.77514077
117MP0002697_abnormal_eye_size0.76947947
118MP0001293_anophthalmia0.76866769
119MP0003186_abnormal_redox_activity0.76243726
120MP0003646_muscle_fatigue0.76069460
121MP0004782_abnormal_surfactant_physiolog0.75138807
122MP0005266_abnormal_metabolism0.73249775
123MP0005023_abnormal_wound_healing0.72201753
124MP0005621_abnormal_cell_physiology0.72098663
125MP0005330_cardiomyopathy0.71609412
126MP0002269_muscular_atrophy0.70935268
127MP0001881_abnormal_mammary_gland0.69940517
128MP0001119_abnormal_female_reproductive0.69162942
129MP0003115_abnormal_respiratory_system0.69113797
130MP0009053_abnormal_anal_canal0.67818656
131MP0003121_genomic_imprinting0.67503577
132MP0002132_abnormal_respiratory_system0.67083284
133MP0001984_abnormal_olfaction0.66938381
134MP0003699_abnormal_female_reproductive0.65695574
135MP0004084_abnormal_cardiac_muscle0.64893667
136MP0000750_abnormal_muscle_regeneration0.63545800
137MP0009333_abnormal_splenocyte_physiolog0.63203379
138MP0003283_abnormal_digestive_organ0.61587068
139MP0001727_abnormal_embryo_implantation0.61158949
140MP0003119_abnormal_digestive_system0.59960365
141MP0008770_decreased_survivor_rate0.59681402
142MP0009278_abnormal_bone_marrow0.59359869
143MP0009672_abnormal_birth_weight0.57483404
144MP0008789_abnormal_olfactory_epithelium0.54834637
145MP0003866_abnormal_defecation0.54254737
146MP0002111_abnormal_tail_morphology0.53825818
147MP0001919_abnormal_reproductive_system0.53408687
148MP0009703_decreased_birth_body0.51302701
149MP0000703_abnormal_thymus_morphology0.50748354
150MP0002234_abnormal_pharynx_morphology0.50657710

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.04828157
2Chronic bronchitis (HP:0004469)4.82106024
3Rhinitis (HP:0012384)4.33909104
4Abnormal respiratory motile cilium physiology (HP:0012261)4.21601791
5Abnormality of cells of the erythroid lineage (HP:0012130)4.07131586
6Abnormal number of erythroid precursors (HP:0012131)3.85830394
7Abnormal respiratory motile cilium morphology (HP:0005938)3.71138160
8Abnormal respiratory epithelium morphology (HP:0012253)3.71138160
9Selective tooth agenesis (HP:0001592)3.67607849
10Short nail (HP:0001799)3.59477873
11Breast hypoplasia (HP:0003187)3.52788272
12Birth length less than 3rd percentile (HP:0003561)3.44308390
13Abnormality of the distal phalanges of the toes (HP:0010182)3.31783458
14Oral leukoplakia (HP:0002745)3.24153779
1511 pairs of ribs (HP:0000878)3.22876570
16Degeneration of anterior horn cells (HP:0002398)3.20897127
17Abnormality of the anterior horn cell (HP:0006802)3.20897127
18Absent/shortened dynein arms (HP:0200106)3.13461320
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.13461320
20Carpal bone hypoplasia (HP:0001498)3.12798688
21Ependymoma (HP:0002888)3.02769479
22Reticulocytopenia (HP:0001896)3.02071865
23Impulsivity (HP:0100710)2.92422884
24Abnormal ciliary motility (HP:0012262)2.92219899
25Atelectasis (HP:0100750)2.90788845
26Premature rupture of membranes (HP:0001788)2.87012205
27Nasal polyposis (HP:0100582)2.86800474
28Colon cancer (HP:0003003)2.85253210
29Distal lower limb muscle weakness (HP:0009053)2.71791745
30Distal upper limb amyotrophy (HP:0007149)2.69245739
31Upper limb amyotrophy (HP:0009129)2.69245739
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68292066
33Supernumerary spleens (HP:0009799)2.67518330
34Recurrent otitis media (HP:0000403)2.59756169
35Trismus (HP:0000211)2.57647380
36Patellar aplasia (HP:0006443)2.54684040
37Broad distal phalanx of finger (HP:0009836)2.51648115
38Bronchiectasis (HP:0002110)2.51419776
39Cerebral hypomyelination (HP:0006808)2.51015041
40Hyperacusis (HP:0010780)2.48026824
41Microretrognathia (HP:0000308)2.47591604
42Missing ribs (HP:0000921)2.47115373
43Premature ovarian failure (HP:0008209)2.45864833
44Abnormality of the nasal mucosa (HP:0000433)2.45556296
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.43092822
46Abnormality of the heme biosynthetic pathway (HP:0010472)2.42341982
47Hand muscle atrophy (HP:0009130)2.41595583
48Achilles tendon contracture (HP:0001771)2.40596638
49Medulloblastoma (HP:0002885)2.39775154
50Abnormal spermatogenesis (HP:0008669)2.39230919
51Ulnar bowing (HP:0003031)2.38958882
52Aplasia/Hypoplasia of the patella (HP:0006498)2.37758375
53Bronchitis (HP:0012387)2.37267779
54Absent thumb (HP:0009777)2.35525461
55Neoplasm of the pancreas (HP:0002894)2.29838089
56Rhabdomyosarcoma (HP:0002859)2.29828641
57Flat acetabular roof (HP:0003180)2.27051995
58Spinal cord compression (HP:0002176)2.26062605
59Rough bone trabeculation (HP:0100670)2.23272300
60Abnormality of the umbilical cord (HP:0010881)2.22976156
61Infertility (HP:0000789)2.20786085
62Abdominal situs inversus (HP:0003363)2.18032119
63Abnormality of abdominal situs (HP:0011620)2.18032119
64Macrocytic anemia (HP:0001972)2.17858353
65Abnormality of the Achilles tendon (HP:0005109)2.17811072
66Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16788026
67Aplastic anemia (HP:0001915)2.14090182
68Abnormality of the preputium (HP:0100587)2.14052204
69Duodenal stenosis (HP:0100867)2.12469938
70Small intestinal stenosis (HP:0012848)2.12469938
71Biliary tract neoplasm (HP:0100574)2.12193297
72Multiple enchondromatosis (HP:0005701)2.11521149
73Sloping forehead (HP:0000340)2.09880805
74Limb-girdle muscle atrophy (HP:0003797)2.09033563
75Bell-shaped thorax (HP:0001591)2.08506754
76Angiofibromas (HP:0010615)2.07814202
77Adenoma sebaceum (HP:0009720)2.07814202
78Facial cleft (HP:0002006)2.07126488
79Cholecystitis (HP:0001082)2.06888640
80Abnormal gallbladder physiology (HP:0012438)2.06888640
81Distal lower limb amyotrophy (HP:0008944)2.06582222
82Progressive muscle weakness (HP:0003323)2.03914730
83Abnormality of reticulocytes (HP:0004312)2.03157894
84Chromsome breakage (HP:0040012)2.02988999
85Abnormality of the labia minora (HP:0012880)2.01070859
86Vertebral compression fractures (HP:0002953)2.01015944
87Occipital encephalocele (HP:0002085)2.00007225
88Abnormality of the lower motor neuron (HP:0002366)1.99165131
89Pallor (HP:0000980)1.98765161
90Meckel diverticulum (HP:0002245)1.98175156
91Basal cell carcinoma (HP:0002671)1.97958434
92Pelvic girdle muscle weakness (HP:0003749)1.97633826
93Abnormality of carpal bone ossification (HP:0006257)1.96724957
94Glossoptosis (HP:0000162)1.96309266
95Abnormality of dentin (HP:0010299)1.94128067
96Abnormality of chromosome stability (HP:0003220)1.93516171
97Male infertility (HP:0003251)1.93203032
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.92700294
99Protrusio acetabuli (HP:0003179)1.90925504
100Increased nuchal translucency (HP:0010880)1.90698339
101Secondary amenorrhea (HP:0000869)1.90379416
102Neoplasm of the colon (HP:0100273)1.88883252
103Flattened epiphyses (HP:0003071)1.88266389
104Deviation of the thumb (HP:0009603)1.87851352
105Glucose intolerance (HP:0000833)1.87205143
106Overlapping toe (HP:0001845)1.86042905
107Abnormality of the fetal cardiovascular system (HP:0010948)1.85536337
108Abnormal umbilical cord blood vessels (HP:0011403)1.85536337
109Single umbilical artery (HP:0001195)1.85536337
110Ovarian neoplasm (HP:0100615)1.85470494
111Abnormality of the ileum (HP:0001549)1.84249827
112Hyperactive renin-angiotensin system (HP:0000841)1.82697144
113Proximal placement of thumb (HP:0009623)1.82092104
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.81934478
115Shoulder girdle muscle weakness (HP:0003547)1.81368860
116Astrocytoma (HP:0009592)1.81215880
117Abnormality of the astrocytes (HP:0100707)1.81215880
118Self-mutilation (HP:0000742)1.80871342
119Broad face (HP:0000283)1.80203031
120Osteolytic defects of the phalanges of the hand (HP:0009771)1.80184043
121Osteolytic defects of the hand bones (HP:0009699)1.80184043
122Stridor (HP:0010307)1.79140906
123Intestinal polyp (HP:0005266)1.79058345
124Pili torti (HP:0003777)1.78440495
125Neoplasm of the rectum (HP:0100743)1.78398118
126Elbow flexion contracture (HP:0002987)1.78378140
127Difficulty climbing stairs (HP:0003551)1.78018894
128Insomnia (HP:0100785)1.77961898
129Abnormal ossification of hand bones (HP:0005921)1.77615660
130Absent epiphyses (HP:0010577)1.77437471
131Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77437471
132Recurrent sinusitis (HP:0011108)1.76228278
133Intestinal polyposis (HP:0200008)1.75934598
134High pitched voice (HP:0001620)1.74647216
135Abnormalities of placenta or umbilical cord (HP:0001194)1.74324382
136Increased connective tissue (HP:0009025)1.73877321
137Myelodysplasia (HP:0002863)1.73723098
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.73055784
139Aplasia/Hypoplasia of the uvula (HP:0010293)1.72478016
140Back pain (HP:0003418)1.71712111
141Diaphragmatic weakness (HP:0009113)1.71675388
142Absent radius (HP:0003974)1.71535349
143Abnormal lung lobation (HP:0002101)1.71213761
144Prominent nose (HP:0000448)1.70677727
145Cafe-au-lait spot (HP:0000957)1.70148963
146Irregular epiphyses (HP:0010582)1.70136240
147Emotional lability (HP:0000712)1.70131275
148Ragged-red muscle fibers (HP:0003200)1.69220744
149Progressive hearing impairment (HP:0001730)1.68409859
150Natal tooth (HP:0000695)1.65173390
151Down-sloping shoulders (HP:0200021)1.65088382
152Spinal rigidity (HP:0003306)1.64230735
153Mildly elevated creatine phosphokinase (HP:0008180)1.57822816
154Absent frontal sinuses (HP:0002688)1.55328518
155Abnormal trabecular bone morphology (HP:0100671)1.54161736
156Fragile skin (HP:0001030)1.53564189
157Chronic sinusitis (HP:0011109)1.52690868
158Flared metaphyses (HP:0003015)1.51437703
159Entropion (HP:0000621)1.50978502
160Vascular calcification (HP:0004934)1.49786681
161Progressive sensorineural hearing impairment (HP:0000408)1.49025307
162Bifid scrotum (HP:0000048)1.46576505
163Sparse eyelashes (HP:0000653)1.44822865
164Ankyloglossia (HP:0010296)1.43769321
165Long palpebral fissure (HP:0000637)1.43328210
166Reduced subcutaneous adipose tissue (HP:0003758)1.41974341
167Abnormality of glycolysis (HP:0004366)1.41881697
168Abnormality of the acetabulum (HP:0003170)1.41035768
169Generalized amyotrophy (HP:0003700)1.40561090
170Cervical subluxation (HP:0003308)1.40256315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.04139983
2WEE14.40162508
3CDC73.67993244
4SMG13.46528182
5NEK23.05404170
6NEK12.91837736
7PDK42.79685129
8PDK32.79685129
9PBK2.64119049
10MST1R2.61271527
11MAPK152.59075705
12TTK2.41987628
13TESK12.32660138
14EEF2K2.27345728
15BRSK22.17366081
16EIF2AK12.16718043
17IRAK32.02999106
18MAPKAPK32.01170507
19PLK11.90479035
20RPS6KB21.89955552
21BRSK11.84519982
22TESK21.84337899
23SCYL21.80854700
24VRK21.79810375
25AURKA1.67324565
26STK101.63583986
27AURKB1.62895292
28DYRK31.57087665
29TSSK61.51334116
30PDK21.43551333
31TRIB31.42582651
32NME21.39093127
33MAP3K81.39019279
34MET1.36236440
35ACVR1B1.32883103
36EPHA21.32066920
37RPS6KA41.30815098
38CDK71.27164687
39PKN21.26300132
40PNCK1.26249521
41CCNB11.25504816
42PLK41.23753642
43SIK11.21977127
44VRK11.21215366
45PTK21.19337254
46PASK1.19179506
47PAK41.18934554
48ATR1.14591100
49PLK31.10100818
50CHEK21.09373403
51TAOK21.06562488
52LMTK21.05124545
53CDK41.02463082
54STK161.01569769
55SRPK11.01154662
56BRAF1.00936087
57CHEK10.97340311
58CDK120.97054490
59LRRK20.93448402
60MAP3K100.93034502
61PAK10.92236459
62LATS20.92027092
63TLK10.87359525
64MAP3K110.87127159
65PIM20.84770213
66ERN10.82412489
67PRPF4B0.82137816
68EIF2AK30.75256409
69LIMK10.73418322
70PRKCI0.72773884
71ERBB40.72193729
72TGFBR10.71242339
73MAP2K20.70065445
74ICK0.68682491
75PRKD30.65891222
76FLT30.63465626
77PTK60.62973040
78STK40.62787012
79MAP3K20.60524242
80ATM0.58971081
81PDGFRA0.58204522
82ARAF0.57932953
83CDK20.57462217
84MST40.55890237
85NTRK10.55288791
86ILK0.54211869
87STK30.52974860
88MATK0.52756906
89TAOK10.51992679
90ABL20.51890505
91MAP3K120.50997933
92KSR20.49585422
93CSNK2A20.48762775
94EPHB10.47829618
95EPHB20.45879474
96BMX0.45569262
97MAP2K30.43896354
98CDK80.43196046
99CDK180.42705048
100MTOR0.42291945
101ALK0.42091645
102CDK90.41600934
103CSNK2A10.41313431
104AKT20.39722201
105CLK10.39648608
106CDK10.39400536
107MELK0.39250742
108CDK60.38530045
109PAK20.38354039
110CAMK2G0.38113125
111FGFR40.37563500
112MAP3K30.37459943
113MAPK110.36952342
114STK38L0.36740929
115MAPKAPK20.36283643
116KDR0.35759358
117NME10.35694085
118TTN0.35363699
119MOS0.33553386
120RIPK10.33303015
121MYLK0.33199049
122PIM10.33030068
123MINK10.31822804
124CDK140.31521836
125CSNK1E0.31190837
126MKNK10.30601799
127BCKDK0.30453936
128CDK11A0.29724841
129CDK150.27845557
130GRK60.27155261
131DAPK10.27001396

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07852301
2Mismatch repair_Homo sapiens_hsa034304.09196804
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36014259
4Proteasome_Homo sapiens_hsa030503.34270846
5RNA transport_Homo sapiens_hsa030133.13331858
6Cell cycle_Homo sapiens_hsa041103.01555906
7Base excision repair_Homo sapiens_hsa034102.95506903
8Spliceosome_Homo sapiens_hsa030402.87701245
9Ribosome_Homo sapiens_hsa030102.86149623
10Nucleotide excision repair_Homo sapiens_hsa034202.84067734
11Homologous recombination_Homo sapiens_hsa034402.71867786
12RNA polymerase_Homo sapiens_hsa030202.69431824
13Phenylalanine metabolism_Homo sapiens_hsa003602.51077300
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.50053992
15Pyrimidine metabolism_Homo sapiens_hsa002402.44958468
16One carbon pool by folate_Homo sapiens_hsa006701.95827866
17Fanconi anemia pathway_Homo sapiens_hsa034601.90982509
18Basal transcription factors_Homo sapiens_hsa030221.90612510
19Oocyte meiosis_Homo sapiens_hsa041141.81490855
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67107474
21Tyrosine metabolism_Homo sapiens_hsa003501.59543849
22p53 signaling pathway_Homo sapiens_hsa041151.59229503
23mRNA surveillance pathway_Homo sapiens_hsa030151.58615960
24RNA degradation_Homo sapiens_hsa030181.51950757
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.50607962
26Purine metabolism_Homo sapiens_hsa002301.45426601
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.43101431
28Pentose phosphate pathway_Homo sapiens_hsa000301.36608614
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33419862
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.33185427
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31869581
32Non-homologous end-joining_Homo sapiens_hsa034501.30978475
33Huntingtons disease_Homo sapiens_hsa050161.27095784
34Biosynthesis of amino acids_Homo sapiens_hsa012301.26909469
35Systemic lupus erythematosus_Homo sapiens_hsa053221.18469135
36Vitamin B6 metabolism_Homo sapiens_hsa007501.18456918
37Sulfur relay system_Homo sapiens_hsa041221.11558881
38Carbon metabolism_Homo sapiens_hsa012001.10576905
39Epstein-Barr virus infection_Homo sapiens_hsa051691.10560043
40Pyruvate metabolism_Homo sapiens_hsa006201.10470223
41Vibrio cholerae infection_Homo sapiens_hsa051101.09624373
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.06877796
43Adherens junction_Homo sapiens_hsa045201.04479008
44Selenocompound metabolism_Homo sapiens_hsa004501.01901655
45Viral carcinogenesis_Homo sapiens_hsa052031.01653903
46Thyroid cancer_Homo sapiens_hsa052160.98412090
47Parkinsons disease_Homo sapiens_hsa050120.98376364
48Fatty acid elongation_Homo sapiens_hsa000620.97850147
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.91516812
50Arginine and proline metabolism_Homo sapiens_hsa003300.91007515
51Glutathione metabolism_Homo sapiens_hsa004800.91006459
52Histidine metabolism_Homo sapiens_hsa003400.89797220
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87320702
54Prion diseases_Homo sapiens_hsa050200.81752513
55Alcoholism_Homo sapiens_hsa050340.78002893
56Arginine biosynthesis_Homo sapiens_hsa002200.77812130
57Pancreatic cancer_Homo sapiens_hsa052120.77460095
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77352487
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.73810959
60Sphingolipid metabolism_Homo sapiens_hsa006000.72417951
61Steroid biosynthesis_Homo sapiens_hsa001000.71452812
62* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69031554
63Notch signaling pathway_Homo sapiens_hsa043300.67673778
64Fructose and mannose metabolism_Homo sapiens_hsa000510.67400900
65Antigen processing and presentation_Homo sapiens_hsa046120.67389479
66Proteoglycans in cancer_Homo sapiens_hsa052050.66344562
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.66216330
68beta-Alanine metabolism_Homo sapiens_hsa004100.64684664
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63827427
70Chemical carcinogenesis_Homo sapiens_hsa052040.63259986
71HTLV-I infection_Homo sapiens_hsa051660.62324705
72Bladder cancer_Homo sapiens_hsa052190.58281563
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58134708
74Oxidative phosphorylation_Homo sapiens_hsa001900.56631701
75Folate biosynthesis_Homo sapiens_hsa007900.55979372
76Non-small cell lung cancer_Homo sapiens_hsa052230.55157532
77Other glycan degradation_Homo sapiens_hsa005110.54507841
78ECM-receptor interaction_Homo sapiens_hsa045120.52655918
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.52113102
80N-Glycan biosynthesis_Homo sapiens_hsa005100.51606510
81Hippo signaling pathway_Homo sapiens_hsa043900.50585732
82Focal adhesion_Homo sapiens_hsa045100.49648529
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.48970899
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47504175
85Small cell lung cancer_Homo sapiens_hsa052220.46691432
86Prostate cancer_Homo sapiens_hsa052150.46081972
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45353581
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45003464
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42680381
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41580727
91Tight junction_Homo sapiens_hsa045300.40850303
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40732843
93Colorectal cancer_Homo sapiens_hsa052100.40194670
94Apoptosis_Homo sapiens_hsa042100.39772579
95Herpes simplex infection_Homo sapiens_hsa051680.37884373
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36548211
97Glucagon signaling pathway_Homo sapiens_hsa049220.34941749
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.34659737
99Lysine degradation_Homo sapiens_hsa003100.33149301
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30418389
101MicroRNAs in cancer_Homo sapiens_hsa052060.29032619
102HIF-1 signaling pathway_Homo sapiens_hsa040660.28604005
103VEGF signaling pathway_Homo sapiens_hsa043700.28474149
104Galactose metabolism_Homo sapiens_hsa000520.27553585
105Metabolic pathways_Homo sapiens_hsa011000.25677566
106Cardiac muscle contraction_Homo sapiens_hsa042600.25610316
107TGF-beta signaling pathway_Homo sapiens_hsa043500.25585214
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24573832
109Renin-angiotensin system_Homo sapiens_hsa046140.24424079
110Alzheimers disease_Homo sapiens_hsa050100.23457898
111Chronic myeloid leukemia_Homo sapiens_hsa052200.23304560
112Legionellosis_Homo sapiens_hsa051340.23082359
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23037392
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22858478
115Hedgehog signaling pathway_Homo sapiens_hsa043400.22636908
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22634217
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22236046
118mTOR signaling pathway_Homo sapiens_hsa041500.21318917
119Insulin signaling pathway_Homo sapiens_hsa049100.18762194
120Basal cell carcinoma_Homo sapiens_hsa052170.18621056
121AMPK signaling pathway_Homo sapiens_hsa041520.17412901
122Shigellosis_Homo sapiens_hsa051310.16041612
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15948965
124Linoleic acid metabolism_Homo sapiens_hsa005910.13599257
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.13195534
126Endometrial cancer_Homo sapiens_hsa052130.12136025
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11874762
128Pathways in cancer_Homo sapiens_hsa052000.11429392
129Olfactory transduction_Homo sapiens_hsa047400.11371814
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10293033
131Hepatitis B_Homo sapiens_hsa051610.10006639
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09161152

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