TUBB4BP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation, ncRNA-mediated (GO:0040033)7.11032737
2regulation of translation, ncRNA-mediated (GO:0045974)7.11032737
3negative regulation of translation involved in gene silencing by miRNA (GO:0035278)7.11032737
4regulation of histone H3-K9 methylation (GO:0051570)6.10940875
5negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 5.63079648
6negative regulation of histone methylation (GO:0031061)5.02479800
7positive regulation of hormone biosynthetic process (GO:0046886)4.97937681
8ventricular trabecula myocardium morphogenesis (GO:0003222)4.94126972
9regulation of posttranscriptional gene silencing (GO:0060147)4.92353024
10regulation of gene silencing by miRNA (GO:0060964)4.92353024
11regulation of gene silencing by RNA (GO:0060966)4.92353024
12regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 4.86421529
13anterior/posterior axis specification, embryo (GO:0008595)4.53923148
14negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)4.36148085
15ribosomal small subunit biogenesis (GO:0042274)4.34850294
16maturation of SSU-rRNA (GO:0030490)4.29482566
17positive regulation of megakaryocyte differentiation (GO:0045654)4.28228706
18cell wall macromolecule catabolic process (GO:0016998)4.22972028
19heart trabecula morphogenesis (GO:0061384)4.16976135
20regulation of translation in response to stress (GO:0043555)4.16426212
21pituitary gland development (GO:0021983)4.10127790
22rRNA modification (GO:0000154)3.95741382
23negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.93126594
24rRNA methylation (GO:0031167)3.85022742
25chromatin remodeling at centromere (GO:0031055)3.73288265
26CENP-A containing nucleosome assembly (GO:0034080)3.69546596
27spliceosomal complex assembly (GO:0000245)3.69311309
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.66426700
29pre-miRNA processing (GO:0031054)3.63270246
30phosphate ion homeostasis (GO:0055062)3.62867747
31trivalent inorganic anion homeostasis (GO:0072506)3.62867747
32generation of neurons (GO:0048699)3.61594809
33regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.60640580
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.56367682
35primitive streak formation (GO:0090009)3.55830984
36regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.55542408
37cellular anion homeostasis (GO:0030002)3.53105638
38chaperone-mediated protein transport (GO:0072321)3.51343510
39histone H3-K9 demethylation (GO:0033169)3.50286877
40regulation of centriole replication (GO:0046599)3.48082324
41ribosomal large subunit biogenesis (GO:0042273)3.46597430
42cell wall macromolecule metabolic process (GO:0044036)3.46123888
43positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.43954788
44positive regulation of hormone metabolic process (GO:0032352)3.38355546
45viral transcription (GO:0019083)3.29612880
46translational termination (GO:0006415)3.26432312
47metanephric mesenchyme development (GO:0072075)3.18432949
48leukotriene biosynthetic process (GO:0019370)3.15114761
49regulation of histone H3-K4 methylation (GO:0051569)3.13742998
50histone exchange (GO:0043486)3.13031559
51protein localization to kinetochore (GO:0034501)3.12300591
52protein ADP-ribosylation (GO:0006471)3.12156854
53mating behavior (GO:0007617)3.07975608
54serine family amino acid biosynthetic process (GO:0009070)3.05294967
55negative regulation of androgen receptor signaling pathway (GO:0060766)3.01929960
56negative regulation of signal transduction by p53 class mediator (GO:1901797)3.00391472
57trabecula morphogenesis (GO:0061383)2.99339225
58meiotic chromosome segregation (GO:0045132)2.96392211
59ribonucleoprotein complex biogenesis (GO:0022613)2.96348026
60L-serine metabolic process (GO:0006563)2.94392024
61lateral ventricle development (GO:0021670)2.92549256
62negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91489767
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90891090
64granulocyte differentiation (GO:0030851)2.90284510
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89299299
66somatic stem cell division (GO:0048103)2.88896961
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.88070483
68cotranslational protein targeting to membrane (GO:0006613)2.87930492
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.86455887
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.85945567
71spliceosomal snRNP assembly (GO:0000387)2.84538465
72translational initiation (GO:0006413)2.83989712
73rRNA processing (GO:0006364)2.82721008
74ribosomal small subunit assembly (GO:0000028)2.82267089
75DNA replication-independent nucleosome organization (GO:0034724)2.80806710
76DNA replication-independent nucleosome assembly (GO:0006336)2.80806710
77telomere maintenance via semi-conservative replication (GO:0032201)2.77412077
78ATP synthesis coupled proton transport (GO:0015986)2.77127179
79energy coupled proton transport, down electrochemical gradient (GO:0015985)2.77127179
80phosphate ion transmembrane transport (GO:0035435)2.76507000
81myoblast migration (GO:0051451)2.75248813
82protein targeting to ER (GO:0045047)2.75183784
83negative regulation of translational initiation (GO:0045947)2.72157143
84rRNA metabolic process (GO:0016072)2.70367313
85mitotic sister chromatid segregation (GO:0000070)2.70329965
86establishment of protein localization to endoplasmic reticulum (GO:0072599)2.70294099
87DNA replication initiation (GO:0006270)2.68599456
88establishment or maintenance of monopolar cell polarity (GO:0061339)2.66305199
89establishment of monopolar cell polarity (GO:0061162)2.66305199
90histone H3-K36 demethylation (GO:0070544)2.66153141
91negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (GO:1902230)2.65605824
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65436630
93kidney mesenchyme development (GO:0072074)2.65224825
94stem cell division (GO:0017145)2.63439832
95DNA strand elongation involved in DNA replication (GO:0006271)2.62136581
96sister chromatid segregation (GO:0000819)2.60413878
97protein localization to chromosome, centromeric region (GO:0071459)2.59260102
98DNA replication checkpoint (GO:0000076)2.58493745
99phosphate ion transport (GO:0006817)2.58172502
100N-acetylglucosamine metabolic process (GO:0006044)2.58043894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.32730113
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.90211432
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30611034
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.30354872
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.30354872
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.30354872
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.16839709
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.05741175
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05005475
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.76415275
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.65331193
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.62326833
13NANOG_16153702_ChIP-ChIP_HESCs_Human2.60561912
14POU5F1_16153702_ChIP-ChIP_HESCs_Human2.59672720
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58351370
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56785905
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.47153933
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.40522539
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36039779
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27308082
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25521549
22NOTCH1_21737748_ChIP-Seq_TLL_Human2.21392397
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15854201
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05618150
25THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99201032
26SOX2_16153702_ChIP-ChIP_HESCs_Human1.96818487
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96017318
28JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.94249815
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92624127
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90681736
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82449645
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80171618
33XRN2_22483619_ChIP-Seq_HELA_Human1.73872392
34TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.69103170
35POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.69103170
36VDR_22108803_ChIP-Seq_LS180_Human1.65975816
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62563560
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61733373
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60691291
40SOX2_18555785_ChIP-Seq_MESCs_Mouse1.58864357
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56862507
42EWS_26573619_Chip-Seq_HEK293_Human1.53337464
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.53062597
44TTF2_22483619_ChIP-Seq_HELA_Human1.52274164
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47900010
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.44421363
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37087055
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33978997
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32451607
50ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30433169
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29076317
52FUS_26573619_Chip-Seq_HEK293_Human1.28985613
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.28294147
54P300_19829295_ChIP-Seq_ESCs_Human1.28228401
55VDR_23849224_ChIP-Seq_CD4+_Human1.28183355
56GBX2_23144817_ChIP-Seq_PC3_Human1.23755524
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23440245
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21463141
59KDM5A_27292631_Chip-Seq_BREAST_Human1.17581256
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15942380
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13722346
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13717547
63FOXP3_21729870_ChIP-Seq_TREG_Human1.13240521
64ELK1_19687146_ChIP-ChIP_HELA_Human1.11745767
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.10779942
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10583364
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09456597
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08263395
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06962673
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06828426
71HTT_18923047_ChIP-ChIP_STHdh_Human1.06395530
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04157880
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03664334
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03456925
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01144978
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99750702
77ZNF263_19887448_ChIP-Seq_K562_Human0.98637034
78EZH2_22144423_ChIP-Seq_EOC_Human0.98541380
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98489983
80SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98129432
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95746801
82LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95519925
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.94807718
84POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93256673
85CTBP2_25329375_ChIP-Seq_LNCAP_Human0.92289273
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91099244
87MYC_18940864_ChIP-ChIP_HL60_Human0.90933794
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87460799
89GABP_19822575_ChIP-Seq_HepG2_Human0.86482334
90TCF3_18692474_ChIP-Seq_MESCs_Mouse0.83980540
91AR_21572438_ChIP-Seq_LNCaP_Human0.83389744
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.82764033
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81324520
94SOX9_26525672_Chip-Seq_HEART_Mouse0.79999225
95POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.78523380
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77978662
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.77752649
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.77411843
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.76243586
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.73467539

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.81132419
2MP0008057_abnormal_DNA_replication4.28989197
3MP0002736_abnormal_nociception_after3.24908434
4MP0003646_muscle_fatigue2.82448698
5MP0004957_abnormal_blastocyst_morpholog2.71449212
6MP0006292_abnormal_olfactory_placode2.68906858
7MP0003123_paternal_imprinting2.59481460
8MP0003121_genomic_imprinting2.50076297
9MP0003787_abnormal_imprinting2.49226928
10MP0002254_reproductive_system_inflammat2.40833660
11MP0000569_abnormal_digit_pigmentation2.37973879
12MP0003890_abnormal_embryonic-extraembry2.36629075
13MP0003567_abnormal_fetal_cardiomyocyte2.30660677
14MP0003937_abnormal_limbs/digits/tail_de2.30565567
15MP0003315_abnormal_perineum_morphology2.17291624
16MP0003136_yellow_coat_color2.17087545
17MP0003941_abnormal_skin_development2.12974244
18MP0003111_abnormal_nucleus_morphology2.11236161
19MP0003878_abnormal_ear_physiology1.97597657
20MP0005377_hearing/vestibular/ear_phenot1.97597657
21MP0004133_heterotaxia1.97197969
22MP0005083_abnormal_biliary_tract1.96868443
23MP0003077_abnormal_cell_cycle1.94754365
24MP0005187_abnormal_penis_morphology1.90598971
25MP0005174_abnormal_tail_pigmentation1.83011355
26MP0001968_abnormal_touch/_nociception1.79091443
27MP0010352_gastrointestinal_tract_polyps1.70185235
28MP0002822_catalepsy1.63057276
29MP0008058_abnormal_DNA_repair1.57231870
30MP0004233_abnormal_muscle_weight1.57064187
31MP0003122_maternal_imprinting1.54613224
32MP0008932_abnormal_embryonic_tissue1.50274175
33MP0002653_abnormal_ependyma_morphology1.48145997
34MP0000631_abnormal_neuroendocrine_gland1.47226668
35MP0005220_abnormal_exocrine_pancreas1.46970348
36MP0010094_abnormal_chromosome_stability1.40904014
37MP0003806_abnormal_nucleotide_metabolis1.37599038
38MP0001984_abnormal_olfaction1.36562780
39MP0001346_abnormal_lacrimal_gland1.34738001
40MP0001293_anophthalmia1.31931671
41MP0001919_abnormal_reproductive_system1.28520092
42MP0002160_abnormal_reproductive_system1.28176726
43MP0002751_abnormal_autonomic_nervous1.25765592
44MP0003718_maternal_effect1.24866973
45MP0008877_abnormal_DNA_methylation1.24133759
46MP0001730_embryonic_growth_arrest1.24071944
47MP0005380_embryogenesis_phenotype1.19101648
48MP0001672_abnormal_embryogenesis/_devel1.19101648
49MP0002277_abnormal_respiratory_mucosa1.18506078
50MP0000470_abnormal_stomach_morphology1.18255396
51MP0002163_abnormal_gland_morphology1.14455833
52MP0009379_abnormal_foot_pigmentation1.13341819
53MP0002734_abnormal_mechanical_nocicepti1.11951021
54MP0009697_abnormal_copulation1.11571336
55MP0003283_abnormal_digestive_organ1.09137642
56MP0004185_abnormal_adipocyte_glucose1.08659520
57MP0005423_abnormal_somatic_nervous1.07323840
58MP0002088_abnormal_embryonic_growth/wei1.06755096
59MP0003984_embryonic_growth_retardation1.03550775
60MP0002084_abnormal_developmental_patter1.02049565
61MP0004742_abnormal_vestibular_system1.01067412
62MP0004197_abnormal_fetal_growth/weight/1.00692753
63MP0001485_abnormal_pinna_reflex0.96648693
64MP0001664_abnormal_digestion0.93162389
65MP0001188_hyperpigmentation0.92870012
66MP0000350_abnormal_cell_proliferation0.91977507
67MP0009384_cardiac_valve_regurgitation0.90122847
68MP0008995_early_reproductive_senescence0.88519618
69MP0004019_abnormal_vitamin_homeostasis0.85585234
70MP0009672_abnormal_birth_weight0.85385312
71MP0002085_abnormal_embryonic_tissue0.84418004
72MP0002697_abnormal_eye_size0.84315142
73MP0006072_abnormal_retinal_apoptosis0.81842506
74MP0003186_abnormal_redox_activity0.79287562
75MP0000613_abnormal_salivary_gland0.78735147
76MP0005084_abnormal_gallbladder_morpholo0.78463271
77MP0002735_abnormal_chemical_nociception0.78450389
78MP0006138_congestive_heart_failure0.77324424
79MP0002080_prenatal_lethality0.77179300
80MP0006035_abnormal_mitochondrial_morpho0.76629379
81MP0003936_abnormal_reproductive_system0.74791056
82MP0005409_darkened_coat_color0.74263621
83MP0003119_abnormal_digestive_system0.74146987
84MP0000778_abnormal_nervous_system0.73725404
85MP0003861_abnormal_nervous_system0.73621594
86MP0002095_abnormal_skin_pigmentation0.73530944
87MP0005389_reproductive_system_phenotype0.73354678
88MP0005379_endocrine/exocrine_gland_phen0.71129772
89MP0002210_abnormal_sex_determination0.70721248
90MP0001286_abnormal_eye_development0.69950891
91MP0003828_pulmonary_edema0.67905528
92MP0002233_abnormal_nose_morphology0.66833152
93MP0000490_abnormal_crypts_of0.66736061
94MP0001502_abnormal_circadian_rhythm0.65178679
95MP0000579_abnormal_nail_morphology0.64562325
96MP0001986_abnormal_taste_sensitivity0.64441051
97MP0008789_abnormal_olfactory_epithelium0.63437394
98MP0008770_decreased_survivor_rate0.59653726
99MP0003942_abnormal_urinary_system0.57775476
100MP0001119_abnormal_female_reproductive0.55592027

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.46151290
2Rectovaginal fistula (HP:0000143)4.45669679
3Rectal fistula (HP:0100590)4.45669679
4Hypophosphatemic rickets (HP:0004912)4.42801272
5Carpal bone hypoplasia (HP:0001498)4.21696457
6Thin bony cortex (HP:0002753)3.94487177
7Intestinal fistula (HP:0100819)3.86018293
8Delayed epiphyseal ossification (HP:0002663)3.85925230
9Abnormality of the costochondral junction (HP:0000919)3.81753813
10Colon cancer (HP:0003003)3.75500652
11Partial duplication of thumb phalanx (HP:0009944)3.68377896
12Vaginal fistula (HP:0004320)3.58517263
13Drooling (HP:0002307)3.42399363
14Abnormal lung lobation (HP:0002101)3.32188032
15Broad-based gait (HP:0002136)3.31732843
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.25973163
17Bifid tongue (HP:0010297)3.20968084
18Septo-optic dysplasia (HP:0100842)3.20016336
19Excessive salivation (HP:0003781)3.14122973
20Partial duplication of the phalanx of hand (HP:0009999)3.10924521
21Aplasia/Hypoplasia of the sternum (HP:0006714)3.08888220
222-3 toe syndactyly (HP:0004691)3.07983378
23Widely patent fontanelles and sutures (HP:0004492)3.07044483
24Enlarged epiphyses (HP:0010580)2.99127489
25Bilateral microphthalmos (HP:0007633)2.92051258
26Choanal stenosis (HP:0000452)2.89693558
27Intestinal atresia (HP:0011100)2.87287812
28Abnormal trabecular bone morphology (HP:0100671)2.70021230
29Facial cleft (HP:0002006)2.66739222
30Abnormal number of erythroid precursors (HP:0012131)2.64012301
31Hyperkalemia (HP:0002153)2.61072825
32Hyperglycinemia (HP:0002154)2.59366954
33Gastrointestinal atresia (HP:0002589)2.58415603
34Midline defect of the nose (HP:0004122)2.58107422
35Thin upper lip vermilion (HP:0000219)2.55380663
36Abnormality of cells of the erythroid lineage (HP:0012130)2.51507995
37Absent eyebrow (HP:0002223)2.48992877
38Increased number of teeth (HP:0011069)2.45388352
39Submucous cleft hard palate (HP:0000176)2.45199564
40Acute lymphatic leukemia (HP:0006721)2.42931565
41Duplication of thumb phalanx (HP:0009942)2.39996628
42Esophageal atresia (HP:0002032)2.38063546
43Urethral obstruction (HP:0000796)2.32219224
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.26966709
45Absent/shortened dynein arms (HP:0200106)2.26966709
46Flat occiput (HP:0005469)2.26470719
47Wide cranial sutures (HP:0010537)2.25965461
48Abnormality of the labia minora (HP:0012880)2.25417599
49Birth length less than 3rd percentile (HP:0003561)2.18109961
50Generalized hypotonia (HP:0001290)2.17391493
51Absent eyelashes (HP:0000561)2.17094611
52Patellar aplasia (HP:0006443)2.15599455
53Microretrognathia (HP:0000308)2.15348000
54Maternal diabetes (HP:0009800)2.13331455
55Facial diplegia (HP:0001349)2.13138514
56Rhabdomyosarcoma (HP:0002859)2.11445699
57Sensory axonal neuropathy (HP:0003390)2.10611437
58Septate vagina (HP:0001153)2.08530931
59Supernumerary spleens (HP:0009799)2.07031176
60Stenosis of the external auditory canal (HP:0000402)2.06154001
61Abnormality of the lacrimal duct (HP:0011481)2.05459885
62Premature ovarian failure (HP:0008209)2.00522913
63Reticulocytopenia (HP:0001896)1.99931448
64Acute encephalopathy (HP:0006846)1.98537069
65Preaxial foot polydactyly (HP:0001841)1.97690182
66Medulloblastoma (HP:0002885)1.96430180
67Macrocytic anemia (HP:0001972)1.95194233
68Oral leukoplakia (HP:0002745)1.94468878
69Hypospadias (HP:0000047)1.90316390
70Abnormality of the labia majora (HP:0012881)1.88662275
71Absent hair (HP:0002298)1.88177106
72Aplasia/Hypoplasia of the patella (HP:0006498)1.87405586
73Hypoplastic labia majora (HP:0000059)1.86287052
74Nonimmune hydrops fetalis (HP:0001790)1.85474459
75Abnormality of methionine metabolism (HP:0010901)1.85298750
76Limb hypertonia (HP:0002509)1.84082382
77Metaphyseal irregularity (HP:0003025)1.83131841
78Abnormality of serum amino acid levels (HP:0003112)1.81601652
79Decreased circulating renin level (HP:0003351)1.81199244
80Chronic bronchitis (HP:0004469)1.79237531
81Broad distal phalanx of finger (HP:0009836)1.79202376
82Abnormality of aspartate family amino acid metabolism (HP:0010899)1.77944386
83Absent radius (HP:0003974)1.74389899
84Abnormality of the nasolacrimal system (HP:0000614)1.73878637
85Hyperactive renin-angiotensin system (HP:0000841)1.73876173
86Absent septum pellucidum (HP:0001331)1.73833679
87Poikiloderma (HP:0001029)1.73799693
88Abnormality of salivation (HP:0100755)1.73471116
89Cellular immunodeficiency (HP:0005374)1.72093316
90Abnormality of the septum pellucidum (HP:0007375)1.71404550
91Dental crowding (HP:0000678)1.71140135
92Gastroesophageal reflux (HP:0002020)1.70839383
93Inability to walk (HP:0002540)1.69349296
94Short 1st metacarpal (HP:0010034)1.69099214
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69099214
96Acute necrotizing encephalopathy (HP:0006965)1.67913433
97Split foot (HP:0001839)1.67434110
98Cupped ear (HP:0000378)1.66161071
99Rib fusion (HP:0000902)1.65669524
100Aplastic anemia (HP:0001915)1.64781798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.64894199
2TNIK4.05963528
3SRPK13.96220025
4TSSK63.85845494
5PNCK3.39936375
6CDC73.36642020
7NUAK13.13249086
8CAMK1G2.35336518
9STK242.26553967
10DYRK32.20207447
11NLK2.18134615
12WNK32.17805483
13STK32.14777731
14VRK22.12704494
15LATS12.01283836
16PLK41.93747149
17TTK1.83457232
18NEK11.78253888
19ACVR1B1.76995484
20EPHA41.64671002
21TESK21.64371409
22CASK1.62633614
23PLK31.62299324
24RPS6KA41.58656877
25EIF2AK11.51083407
26MAP4K21.36328585
27BUB11.32312932
28PIM11.29411780
29CAMK1D1.28952334
30STK41.26005147
31WNK41.24323202
32CDK31.22816086
33IRAK11.20337136
34SGK4941.18655650
35SGK2231.18655650
36DYRK21.14028802
37KSR11.08255693
38PLK11.07993961
39SGK21.03111193
40MAP3K41.01196115
41CDK190.98430358
42STK38L0.95889665
43AKT30.94190117
44PLK20.93661145
45PDK20.92210623
46CAMK10.90333451
47IRAK20.86433425
48CLK10.85844327
49VRK10.83905094
50AURKB0.81618055
51CHEK20.80808133
52ATR0.80137109
53WNK10.78793542
54CSNK1E0.78424408
55PKN20.77898780
56TEC0.73713192
57YES10.70700494
58SGK30.65789938
59TAF10.64784107
60PBK0.63950260
61MARK30.59855007
62DMPK0.58562290
63BMPR1B0.57016754
64MAP3K50.54265694
65MKNK20.54041730
66FGFR10.53178992
67CSNK1A10.52951868
68CHEK10.51038633
69MAP3K90.50763902
70RPS6KA50.48541359
71OXSR10.48417617
72NEK20.47539121
73CAMK2G0.46505534
74PRKCE0.44268966
75CAMK40.43397443
76ATM0.43394429
77STK110.43380334
78DYRK1A0.43033220
79CSNK2A20.42213126
80CDK40.41808692
81EIF2AK30.40893791
82PRKG10.40258220
83TIE10.38990609
84NME10.36988733
85MAP3K110.36102031
86SGK10.34838124
87FRK0.34590629
88ADRBK10.34405070
89RPS6KA10.31141742
90NTRK10.31123246
91CSNK2A10.30601174
92MTOR0.29908331
93GRK60.29324315
94CDK20.29165088
95CSNK1G10.27183561
96GSK3B0.27154890
97CAMK2D0.25648899
98CDK10.25529484
99MAPK100.25302170
100MAPK130.24194318

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.16007214
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78124391
3DNA replication_Homo sapiens_hsa030303.67652671
4Proteasome_Homo sapiens_hsa030503.44585660
5RNA polymerase_Homo sapiens_hsa030203.02884117
6Mismatch repair_Homo sapiens_hsa034302.78930499
7Protein export_Homo sapiens_hsa030602.55585323
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49923908
9Spliceosome_Homo sapiens_hsa030402.37039560
10Oxidative phosphorylation_Homo sapiens_hsa001902.12240437
11RNA transport_Homo sapiens_hsa030132.06145531
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.05709995
13Selenocompound metabolism_Homo sapiens_hsa004501.88561621
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88136823
15Nucleotide excision repair_Homo sapiens_hsa034201.77397116
16Cell cycle_Homo sapiens_hsa041101.75707064
17Huntingtons disease_Homo sapiens_hsa050161.73621065
18Base excision repair_Homo sapiens_hsa034101.73123807
19Steroid biosynthesis_Homo sapiens_hsa001001.68681366
20Pyrimidine metabolism_Homo sapiens_hsa002401.64695683
21Parkinsons disease_Homo sapiens_hsa050121.60668274
22Fanconi anemia pathway_Homo sapiens_hsa034601.55218498
23RNA degradation_Homo sapiens_hsa030181.54173897
24mRNA surveillance pathway_Homo sapiens_hsa030151.47275271
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44478331
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.40812226
27One carbon pool by folate_Homo sapiens_hsa006701.38737264
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37229854
29Purine metabolism_Homo sapiens_hsa002301.35145689
30Homologous recombination_Homo sapiens_hsa034401.30011136
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.29812755
32Basal cell carcinoma_Homo sapiens_hsa052171.24509641
33Glutathione metabolism_Homo sapiens_hsa004801.24140920
34Folate biosynthesis_Homo sapiens_hsa007901.22580705
35Hippo signaling pathway_Homo sapiens_hsa043901.19356674
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16939662
37Arginine biosynthesis_Homo sapiens_hsa002201.12116222
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11802814
39Adherens junction_Homo sapiens_hsa045201.10654582
40Nitrogen metabolism_Homo sapiens_hsa009101.10512987
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.08939644
42Wnt signaling pathway_Homo sapiens_hsa043101.07786139
43Cardiac muscle contraction_Homo sapiens_hsa042601.03712754
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.03231499
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.01565255
46Fatty acid biosynthesis_Homo sapiens_hsa000611.00282630
47Taste transduction_Homo sapiens_hsa047420.99431848
48Nicotine addiction_Homo sapiens_hsa050330.98800251
49Oocyte meiosis_Homo sapiens_hsa041140.98346129
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.98174513
51Basal transcription factors_Homo sapiens_hsa030220.97223529
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97057313
53Sulfur relay system_Homo sapiens_hsa041220.94252002
54Regulation of autophagy_Homo sapiens_hsa041400.93760869
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.92698442
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.89447864
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87484498
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87070090
59Alzheimers disease_Homo sapiens_hsa050100.87022518
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82259157
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79339473
62Thyroid cancer_Homo sapiens_hsa052160.76392113
63Tight junction_Homo sapiens_hsa045300.72538853
64Prostate cancer_Homo sapiens_hsa052150.68173493
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66556240
66TGF-beta signaling pathway_Homo sapiens_hsa043500.61775822
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.60461405
68Epstein-Barr virus infection_Homo sapiens_hsa051690.60343206
69Retinol metabolism_Homo sapiens_hsa008300.59699342
70Ovarian steroidogenesis_Homo sapiens_hsa049130.58241453
71Metabolic pathways_Homo sapiens_hsa011000.57158647
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55069661
73Notch signaling pathway_Homo sapiens_hsa043300.45904519
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44605033
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43983665
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41552651
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35136035
78Phototransduction_Homo sapiens_hsa047440.34815988
79Vitamin digestion and absorption_Homo sapiens_hsa049770.31650970
80N-Glycan biosynthesis_Homo sapiens_hsa005100.30075040
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29571321
82Fatty acid elongation_Homo sapiens_hsa000620.28205537
83Melanogenesis_Homo sapiens_hsa049160.27346649
84Pyruvate metabolism_Homo sapiens_hsa006200.26719523
85p53 signaling pathway_Homo sapiens_hsa041150.26629883
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26374559
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24344121
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24159891
89Cocaine addiction_Homo sapiens_hsa050300.23393215
90Sulfur metabolism_Homo sapiens_hsa009200.20827347
91Starch and sucrose metabolism_Homo sapiens_hsa005000.19450825
92Amphetamine addiction_Homo sapiens_hsa050310.18878268
93Collecting duct acid secretion_Homo sapiens_hsa049660.17865029
94AMPK signaling pathway_Homo sapiens_hsa041520.17782141
95Caffeine metabolism_Homo sapiens_hsa002320.17362166
96Hedgehog signaling pathway_Homo sapiens_hsa043400.16467168
97FoxO signaling pathway_Homo sapiens_hsa040680.16398131
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14229768
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14074596
100Pathways in cancer_Homo sapiens_hsa052000.11846048

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