ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of growth hormone secretion (GO:0060124)	9.28507194
2	growth hormone secretion (GO:0030252)	8.71138568
3	negative regulation of oligodendrocyte differentiation (GO:0048715)	8.33481390
4	cerebral cortex neuron differentiation (GO:0021895)	8.28783490
5	regulation of timing of cell differentiation (GO:0048505)	8.04004642
6	response to folic acid (GO:0051593)	7.29838745
7	regulation of development, heterochronic (GO:0040034)	7.24017671
8	musculoskeletal movement (GO:0050881)	7.20549322
9	multicellular organismal movement (GO:0050879)	7.20549322
10	spinal cord association neuron differentiation (GO:0021527)	6.42443408
11	lung secretory cell differentiation (GO:0061140)	6.13638612
12	neuroblast proliferation (GO:0007405)	5.96634904
13	regulation of growth hormone secretion (GO:0060123)	5.89494395
14	regulation of transcription involved in cell fate commitment (GO:0060850)	5.86780225
15	auditory behavior (GO:0031223)	5.76851581
16	reflex (GO:0060004)	5.65326801
17	pyrimidine nucleobase catabolic process (GO:0006208)	5.53546179
18	forebrain neuron differentiation (GO:0021879)	5.25111469
19	sympathetic nervous system development (GO:0048485)	5.23096629
20	olfactory bulb development (GO:0021772)	5.18839436
21	neuron fate commitment (GO:0048663)	5.10589911
22	synaptic vesicle maturation (GO:0016188)	4.94828524
23	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	4.76569050
24	regulation of circadian sleep/wake cycle (GO:0042749)	4.76569050
25	neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)	4.76104016
26	layer formation in cerebral cortex (GO:0021819)	4.62185539
27	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.54692393
28	nucleobase catabolic process (GO:0046113)	4.35497095
29	postsynaptic membrane organization (GO:0001941)	4.34744246
30	negative regulation of muscle hypertrophy (GO:0014741)	4.32898064
31	response to auditory stimulus (GO:0010996)	4.30838802
32	glandular epithelial cell differentiation (GO:0002067)	4.20304405
33	circadian sleep/wake cycle process (GO:0022410)	4.17377371
34	oligodendrocyte development (GO:0014003)	4.16308428
35	negative regulation of glial cell differentiation (GO:0045686)	4.15747430
36	hippocampus development (GO:0021766)	4.06419527
37	positive regulation of circadian rhythm (GO:0042753)	4.06032691
38	cullin deneddylation (GO:0010388)	4.06000819
39	lens fiber cell development (GO:0070307)	4.05471108
40	mechanosensory behavior (GO:0007638)	4.05028734
41	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	3.95217278
42	central nervous system neuron development (GO:0021954)	3.93536031
43	negative regulation of Notch signaling pathway (GO:0045746)	3.83711503
44	response to food (GO:0032094)	3.75190692
45	adenosine receptor signaling pathway (GO:0001973)	3.71418816
46	response to gravity (GO:0009629)	3.64171702
47	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.64061478
48	neuron fate specification (GO:0048665)	3.59502126
49	proximal/distal pattern formation (GO:0009954)	3.56381118
50	regulation of synaptic vesicle exocytosis (GO:2000300)	3.56087860
51	protein deneddylation (GO:0000338)	3.55989647
52	regulation of oligodendrocyte differentiation (GO:0048713)	3.52266969
53	astrocyte differentiation (GO:0048708)	3.51889898
54	membrane assembly (GO:0071709)	3.46837427
55	dendritic spine morphogenesis (GO:0060997)	3.46578809
56	positive regulation of RNA splicing (GO:0033120)	3.34749073
57	righting reflex (GO:0060013)	3.33781442
58	embryonic cranial skeleton morphogenesis (GO:0048701)	3.31571928
59	vocalization behavior (GO:0071625)	3.30825655
60	gamma-aminobutyric acid transport (GO:0015812)	3.29541642
61	negative regulation of gliogenesis (GO:0014014)	3.25411154
62	positive regulation of mast cell degranulation (GO:0043306)	3.23564330
63	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.23564330
64	response to lithium ion (GO:0010226)	3.16551471
65	negative regulation of cardiac muscle hypertrophy (GO:0010614)	3.16264187
66	regulation of vesicle fusion (GO:0031338)	3.15010548
67	chaperone-mediated protein transport (GO:0072321)	3.12758024
68	circadian behavior (GO:0048512)	3.12377173
69	establishment of mitochondrion localization (GO:0051654)	3.11686326
70	regulation of voltage-gated calcium channel activity (GO:1901385)	3.11366189
71	central nervous system projection neuron axonogenesis (GO:0021952)	3.09482678
72	protein retention in ER lumen (GO:0006621)	3.08659471
73	neuron cell-cell adhesion (GO:0007158)	3.04662299
74	neurotransmitter secretion (GO:0007269)	3.03208131
75	rhythmic behavior (GO:0007622)	3.00943759
76	response to morphine (GO:0043278)	2.97027249
77	glial cell development (GO:0021782)	2.96015192
78	COPI coating of Golgi vesicle (GO:0048205)	2.94754152
79	Golgi transport vesicle coating (GO:0048200)	2.94754152
80	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.90048277
81	mitochondrion transport along microtubule (GO:0047497)	2.90048277
82	cellular potassium ion homeostasis (GO:0030007)	2.88580098
83	positive regulation of Notch signaling pathway (GO:0045747)	2.81907650
84	negative regulation of cAMP-mediated signaling (GO:0043951)	2.80720118
85	positive regulation of neural precursor cell proliferation (GO:2000179)	2.78634591
86	regulation of Notch signaling pathway (GO:0008593)	2.78502309
87	protein localization to synapse (GO:0035418)	2.77658723
88	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.77640062
89	regulation of synapse structural plasticity (GO:0051823)	2.77300612
90	response to isoquinoline alkaloid (GO:0014072)	2.76008137
91	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	2.72921962
92	protein refolding (GO:0042026)	2.71710554
93	cAMP-mediated signaling (GO:0019933)	2.70970295
94	neurofilament cytoskeleton organization (GO:0060052)	2.67592433
95	glycine transport (GO:0015816)	2.66914293
96	peptidyl-arginine omega-N-methylation (GO:0035247)	2.66512051
97	protein maturation by protein folding (GO:0022417)	2.65243841
98	regulation of synaptic vesicle transport (GO:1902803)	2.62750875
99	behavioral response to ethanol (GO:0048149)	2.62670678
100	ganglion development (GO:0061548)	10.0861896

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	4.14037090
2	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	4.03851830
3	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	4.03851830
4	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	4.03851830
5	EED_16625203_ChIP-ChIP_MESCs_Mouse	3.28034555
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.18157182
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.01640156
8	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.90363370
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.70278992
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.65879372
11	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.57773318
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.56078024
13	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.47319710
14	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.43054567
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.41652181
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.39875728
17	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.39433424
18	REST_21632747_ChIP-Seq_MESCs_Mouse	2.35365519
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.29155126
20	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	2.26674797
21	TP53_20018659_ChIP-ChIP_R1E_Mouse	2.20883688
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.20015428
23	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.19777819
24	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.19777819
25	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.15433674
26	ZFP281_18757296_ChIP-ChIP_E14_Mouse	2.14295955
27	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.03955662
28	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.02903656
29	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.91906831
30	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.85230346
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.83751339
32	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.83353244
33	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.79502724
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.77224354
35	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.73702617
36	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.70071979
37	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.65407800
38	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.63612419
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.62594394
40	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.57531862
41	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.56714463
42	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.53763988
43	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.53161041
44	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	1.51659964
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.51320021
46	CIITA_25753668_ChIP-Seq_RAJI_Human	1.49807828
47	CTCF_27219007_Chip-Seq_Bcells_Human	1.46128368
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.43865804
49	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.41859369
50	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.40871309
51	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.35241257
52	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.34553067
53	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.30501589
54	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.29683492
55	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.28076777
56	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20003493
57	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.19297636
58	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.19232543
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.16999457
60	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16148461
61	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.16136380
62	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16127282
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.12883974
64	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.11240094
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06914593
66	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.05906612
67	IGF1R_20145208_ChIP-Seq_DFB_Human	1.03414397
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03200323
69	XRN2_22483619_ChIP-Seq_HELA_Human	1.02322173
70	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.93961305
71	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.93190899
72	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.93097185
73	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92926052
74	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.92806257
75	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91388937
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90842781
77	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.90816928
78	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.88925254
79	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87112485
80	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.86187069
81	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.85297981
82	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84502713
83	EOMES_21245162_ChIP-Seq_HESCs_Human	0.83343364
84	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.82509324
85	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.82157259
86	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.80899408
87	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.80355947
88	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.78269839
89	TAF15_26573619_Chip-Seq_HEK293_Human	0.77848812
90	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.74342311
91	CBP_21632823_ChIP-Seq_H3396_Human	0.72749551
92	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.68494835
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.68484294
94	CTCF_21964334_Chip-Seq_Bcells_Human	0.68413535
95	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.68010385
96	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.66314225
97	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.66197076
98	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.66036749
99	GATA1_22025678_ChIP-Seq_K562_Human	0.66013403
100	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.65535858

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008789_abnormal_olfactory_epithelium	4.88504771
2	MP0005394_taste/olfaction_phenotype	4.09822748
3	MP0005499_abnormal_olfactory_system	4.09822748
4	MP0005423_abnormal_somatic_nervous	3.46921681
5	MP0004270_analgesia	3.31502473
6	MP0006072_abnormal_retinal_apoptosis	3.00148860
7	MP0001529_abnormal_vocalization	2.53369359
8	MP0002734_abnormal_mechanical_nocicepti	2.49563513
9	MP0000537_abnormal_urethra_morphology	2.20655773
10	MP0002822_catalepsy	10.0952591
11	MP0004859_abnormal_synaptic_plasticity	1.92633813
12	MP0002751_abnormal_autonomic_nervous	1.92086005
13	MP0009745_abnormal_behavioral_response	1.91598851
14	MP0000778_abnormal_nervous_system	1.91232196
15	MP0004811_abnormal_neuron_physiology	1.84123253
16	MP0005409_darkened_coat_color	1.83982928
17	MP0003635_abnormal_synaptic_transmissio	1.82349597
18	MP0000049_abnormal_middle_ear	1.69893666
19	MP0002095_abnormal_skin_pigmentation	1.68280144
20	MP0001905_abnormal_dopamine_level	1.62120602
21	MP0002064_seizures	1.60853653
22	MP0001348_abnormal_lacrimal_gland	1.60456384
23	MP0002233_abnormal_nose_morphology	1.59160654
24	MP0002735_abnormal_chemical_nociception	1.58637516
25	MP0002733_abnormal_thermal_nociception	1.57852785
26	MP0003123_paternal_imprinting	1.51424210
27	MP0001188_hyperpigmentation	1.48684083
28	MP0000955_abnormal_spinal_cord	1.46737452
29	MP0002572_abnormal_emotion/affect_behav	1.37323588
30	MP0001970_abnormal_pain_threshold	1.35766861
31	MP0004924_abnormal_behavior	1.35013163
32	MP0005386_behavior/neurological_phenoty	1.35013163
33	MP0002063_abnormal_learning/memory/cond	1.27541837
34	MP0005646_abnormal_pituitary_gland	1.25132172
35	MP0001968_abnormal_touch/_nociception	1.22738020
36	MP0006276_abnormal_autonomic_nervous	1.20674445
37	MP0010030_abnormal_orbit_morphology	1.18839574
38	MP0001664_abnormal_digestion	1.18130422
39	MP0000013_abnormal_adipose_tissue	1.17209237
40	MP0003787_abnormal_imprinting	1.17048846
41	MP0002184_abnormal_innervation	1.16647200
42	MP0001502_abnormal_circadian_rhythm	1.15548367
43	MP0002882_abnormal_neuron_morphology	1.13702919
44	MP0001270_distended_abdomen	1.12680297
45	MP0005645_abnormal_hypothalamus_physiol	1.12158014
46	MP0001943_abnormal_respiration	1.12012253
47	MP0003329_amyloid_beta_deposits	1.10311580
48	MP0002557_abnormal_social/conspecific_i	1.07958755
49	MP0000631_abnormal_neuroendocrine_gland	1.07211093
50	MP0009046_muscle_twitch	1.06534815
51	MP0005253_abnormal_eye_physiology	1.04205480
52	MP0005083_abnormal_biliary_tract	1.02636860
53	MP0003634_abnormal_glial_cell	1.02276998
54	MP0001986_abnormal_taste_sensitivity	1.01505422
55	MP0000003_abnormal_adipose_tissue	1.01342042
56	MP0002272_abnormal_nervous_system	0.99755926
57	MP0001440_abnormal_grooming_behavior	0.99646199
58	MP0004036_abnormal_muscle_relaxation	0.99506458
59	MP0000759_abnormal_skeletal_muscle	0.97866680
60	MP0004142_abnormal_muscle_tone	0.95833632
61	MP0000749_muscle_degeneration	0.93501470
62	MP0002069_abnormal_eating/drinking_beha	0.91713135
63	MP0002152_abnormal_brain_morphology	0.91125694
64	MP0000747_muscle_weakness	0.86893251
65	MP0003861_abnormal_nervous_system	0.85997360
66	MP0001984_abnormal_olfaction	0.83460367
67	MP0002066_abnormal_motor_capabilities/c	0.81827062
68	MP0001299_abnormal_eye_distance/	0.80646155
69	MP0009780_abnormal_chondrocyte_physiolo	0.77413300
70	MP0000579_abnormal_nail_morphology	0.75429997
71	MP0000566_synostosis	0.73137540
72	MP0002653_abnormal_ependyma_morphology	0.72233670
73	MP0003880_abnormal_central_pattern	0.71660050
74	MP0001486_abnormal_startle_reflex	0.71320455
75	MP0000751_myopathy	0.70025232
76	MP0005084_abnormal_gallbladder_morpholo	0.69357849
77	MP0003755_abnormal_palate_morphology	0.67886906
78	MP0002876_abnormal_thyroid_physiology	0.65522345
79	MP0002067_abnormal_sensory_capabilities	0.64934606
80	MP0002081_perinatal_lethality	0.64459550
81	MP0010386_abnormal_urinary_bladder	0.64380922
82	MP0003705_abnormal_hypodermis_morpholog	0.63820063
83	MP0004145_abnormal_muscle_electrophysio	0.61817458
84	MP0002089_abnormal_postnatal_growth/wei	0.61305315
85	MP0009053_abnormal_anal_canal	0.59896110
86	MP0000427_abnormal_hair_cycle	0.59290798
87	MP0001177_atelectasis	0.58948614
88	MP0002752_abnormal_somatic_nervous	0.58688921
89	MP0005670_abnormal_white_adipose	0.58479660
90	MP0002896_abnormal_bone_mineralization	0.57390451
91	MP0002909_abnormal_adrenal_gland	0.56745061
92	MP0005187_abnormal_penis_morphology	0.56340802
93	MP0000639_abnormal_adrenal_gland	0.55898119
94	MP0008775_abnormal_heart_ventricle	0.55862545
95	MP0002138_abnormal_hepatobiliary_system	0.53999481
96	MP0005375_adipose_tissue_phenotype	0.53281486
97	MP0003948_abnormal_gas_homeostasis	0.53261412
98	MP0005165_increased_susceptibility_to	0.51296810
99	MP0004484_altered_response_of	0.50770415
100	MP0003868_abnormal_feces_composition	0.50739861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoventilation (HP:0002791)	5.68500478
2	Cerebral palsy (HP:0100021)	4.60622995
3	Primitive neuroectodermal tumor (HP:0030065)	4.02138820
4	Neuroblastic tumors (HP:0004376)	4.02138820
5	Peripheral primitive neuroectodermal neoplasm (HP:0030067)	4.02138820
6	Neuroblastoma (HP:0003006)	4.02138820
7	Lower limb amyotrophy (HP:0007210)	3.97538064
8	Torticollis (HP:0000473)	3.80190117
9	Abnormality of binocular vision (HP:0011514)	3.74663834
10	Diplopia (HP:0000651)	3.74663834
11	Mutism (HP:0002300)	3.50104705
12	Supranuclear gaze palsy (HP:0000605)	3.45041413
13	Palpebral edema (HP:0100540)	3.39334906
14	Obstructive sleep apnea (HP:0002870)	3.37717838
15	Action tremor (HP:0002345)	3.26238235
16	Aqueductal stenosis (HP:0002410)	3.24968866
17	Myokymia (HP:0002411)	3.19062980
18	Chin dimple (HP:0010751)	3.17267969
19	Shallow orbits (HP:0000586)	3.16782102
20	Pheochromocytoma (HP:0002666)	3.13334612
21	Cerebral hypomyelination (HP:0006808)	3.11863741
22	Limb dystonia (HP:0002451)	3.11739942
23	Synostosis involving the elbow (HP:0003938)	3.07410602
24	Humeroradial synostosis (HP:0003041)	3.07410602
25	Chronic obstructive pulmonary disease (HP:0006510)	3.04689583
26	Obstructive lung disease (HP:0006536)	3.04689583
27	Nuclear cataract (HP:0100018)	2.99093769
28	Hypsarrhythmia (HP:0002521)	2.93047074
29	EEG with generalized epileptiform discharges (HP:0011198)	2.92998675
30	Broad metatarsal (HP:0001783)	2.91755695
31	Craniofacial dystonia (HP:0012179)	2.87494949
32	Epileptiform EEG discharges (HP:0011182)	2.77731812
33	CNS hypomyelination (HP:0003429)	2.72977333
34	Neuroendocrine neoplasm (HP:0100634)	2.71883010
35	Focal dystonia (HP:0004373)	2.67534210
36	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.66701836
37	Malignant neoplasm of the central nervous system (HP:0100836)	2.61296672
38	Ankyloglossia (HP:0010296)	2.59303082
39	Epileptic encephalopathy (HP:0200134)	2.58944780
40	Abnormality of the lower motor neuron (HP:0002366)	2.51634951
41	Deformed tarsal bones (HP:0008119)	2.50372883
42	Absent septum pellucidum (HP:0001331)	2.47228184
43	Distal lower limb amyotrophy (HP:0008944)	2.45995125
44	Urinary bladder sphincter dysfunction (HP:0002839)	2.45974453
45	Anxiety (HP:0000739)	2.44266337
46	Choanal stenosis (HP:0000452)	2.43080864
47	Sleep apnea (HP:0010535)	2.36330027
48	Bifid uvula (HP:0000193)	2.36050506
49	Neuroectodermal neoplasm (HP:0030061)	2.33783763
50	Neuroepithelial neoplasm (HP:0030063)	2.33783763
51	Nervous tissue neoplasm (HP:0030060)	2.33783763
52	Depression (HP:0000716)	2.33530673
53	Akinesia (HP:0002304)	2.32855380
54	Abnormality of the columella (HP:0009929)	2.30435102
55	Progressive cerebellar ataxia (HP:0002073)	2.27948640
56	Split foot (HP:0001839)	2.27721356
57	Abnormality of the middle phalanges of the toes (HP:0010183)	2.23625411
58	Broad hallux (HP:0010055)	2.23091385
59	Bronchomalacia (HP:0002780)	2.18642416
60	Acrocyanosis (HP:0001063)	2.16968407
61	Absent/shortened dynein arms (HP:0200106)	2.15601094
62	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.15601094
63	Severe muscular hypotonia (HP:0006829)	2.12453337
64	Periorbital edema (HP:0100539)	2.09539213
65	Aplasia involving bones of the extremities (HP:0009825)	2.07469898
66	Aplasia involving bones of the upper limbs (HP:0009823)	2.07469898
67	Aplasia of the phalanges of the hand (HP:0009802)	2.07469898
68	Conjunctival hamartoma (HP:0100780)	2.07231579
69	Ankle clonus (HP:0011448)	2.06883867
70	Abnormality of the septum pellucidum (HP:0007375)	2.04184796
71	Abnormality of the corticospinal tract (HP:0002492)	2.02502501
72	Abnormality of the labia minora (HP:0012880)	2.01644263
73	Abnormality of complement system (HP:0005339)	1.99408830
74	Facial edema (HP:0000282)	1.99017123
75	Midline defect of the nose (HP:0004122)	1.96446531
76	Athetosis (HP:0002305)	1.95393281
77	Abnormality of the 2nd finger (HP:0004100)	1.94336175
78	Calcaneovalgus deformity (HP:0001848)	1.90930582
79	Thick nail (HP:0001805)	1.90247035
80	Mask-like facies (HP:0000298)	1.88795195
81	Morphological abnormality of the pyramidal tract (HP:0002062)	1.88183466
82	Apathy (HP:0000741)	1.87397912
83	Recurrent corneal erosions (HP:0000495)	1.85855526
84	Unsteady gait (HP:0002317)	1.85257909
85	Hemoptysis (HP:0002105)	1.83887616
86	Reduced subcutaneous adipose tissue (HP:0003758)	1.83617274
87	Tetraplegia (HP:0002445)	1.82418710
88	Emotional lability (HP:0000712)	1.81249461
89	Abnormality of the pericardium (HP:0001697)	1.78044640
90	Poor speech (HP:0002465)	1.77765777
91	Cerebral hemorrhage (HP:0001342)	1.76376063
92	Meningocele (HP:0002435)	1.72949196
93	Broad toe (HP:0001837)	1.72798744
94	Hepatocellular necrosis (HP:0001404)	1.72530118
95	Abnormality of the intervertebral disk (HP:0005108)	1.69073153
96	Bradykinesia (HP:0002067)	1.68325777
97	Bowing of the arm (HP:0006488)	1.68212427
98	Bowed forearm bones (HP:0003956)	1.68212427
99	Anteriorly placed anus (HP:0001545)	1.67081213
100	Myopathic facies (HP:0002058)	1.65712658

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.85900282
2	TESK2	3.66291665
3	PHKG1	3.58286065
4	PHKG2	3.58286065
5	TESK1	3.58154815
6	PAK6	3.38882652
7	MOS	3.25083252
8	RIPK1	2.70224517
9	MAP3K12	2.59596489
10	STK16	2.40384271
11	PRKD3	2.39405041
12	LIMK1	2.34420283
13	LMTK2	2.33711352
14	CSNK1G2	2.33276071
15	CASK	2.26921542
16	NME2	2.12040398
17	SCYL2	2.08280325
18	EPHA3	2.00302792
19	DYRK2	1.90676036
20	FGFR2	1.82401659
21	INSRR	1.65149449
22	CSNK1A1L	1.59898402
23	CSNK1G3	1.54740444
24	NTRK1	1.42960916
25	MINK1	1.39339493
26	NEK9	1.36260074
27	NTRK3	1.35072790
28	EPHB1	1.32213948
29	AURKA	1.29721829
30	TNIK	1.27123320
31	MAP2K7	1.15357302
32	EPHA4	1.14438288
33	CSNK1G1	1.13515817
34	BCKDK	1.11157500
35	CDK19	1.10084947
36	CDK12	0.99682281
37	EPHB2	0.99589720
38	RPS6KA2	0.98109456
39	ABL2	0.94693515
40	NTRK2	0.94410506
41	CAMKK1	0.90559639
42	CDK5	0.86969791
43	CDK14	0.83953944
44	BRSK1	0.82682186
45	VRK2	0.80309358
46	SGK494	0.79792391
47	SGK223	0.79792391
48	DAPK1	0.78930171
49	MARK2	0.76529243
50	CDK15	0.76429816
51	CDK11A	0.76169097
52	CDK18	0.75296063
53	ROCK2	0.74095869
54	MAP3K9	0.72878355
55	ALK	0.72586507
56	ICK	0.69433584
57	TSSK6	0.69045312
58	ERBB2	0.67475859
59	MAPK13	0.66915108
60	PKN1	0.65049230
61	PRKCE	0.63790431
62	CAMKK2	0.63485947
63	DAPK2	0.63363470
64	BUB1	0.58885057
65	ROCK1	0.58531810
66	CAMK1G	0.56643772
67	KSR1	0.56523183
68	BCR	0.54220698
69	CAMK1D	0.54042827
70	ARAF	0.49839113
71	TRIM28	0.49131944
72	MAP3K4	0.48885442
73	PAK2	0.47325930
74	PAK1	0.47173143
75	PAK4	0.46785488
76	HIPK2	0.46129537
77	LATS2	0.45806632
78	CAMK2D	0.45180207
79	SGK3	0.44449446
80	DYRK1A	0.44153635
81	STK11	0.41666012
82	UHMK1	0.39771568
83	ILK	0.38182379
84	CDK9	0.37101025
85	FER	0.36319937
86	SGK2	0.35045918
87	TAOK2	0.33740871
88	PIM2	0.32797707
89	CCNB1	0.32322661
90	PRKG1	0.30441683
91	PRKCG	0.29663474
92	NLK	0.29578795
93	PRKCI	0.27796425
94	PLK2	0.26861223
95	TAOK1	0.26563033
96	MYLK	0.25832082
97	MAP3K1	0.25260018
98	CAMK2A	0.23226409
99	PRKDC	0.20976456
100	PTK2	0.20418713

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.10522989
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.19140508
3	Proteasome_Homo sapiens_hsa03050	3.02411299
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.94885820
5	Allograft rejection_Homo sapiens_hsa05330	2.91036736
6	Type I diabetes mellitus_Homo sapiens_hsa04940	2.75530233
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.66565154
8	Viral myocarditis_Homo sapiens_hsa05416	2.50519848
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.40190789
10	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.18483302
11	GABAergic synapse_Homo sapiens_hsa04727	1.94719113
12	Dopaminergic synapse_Homo sapiens_hsa04728	1.91297506
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88917501
14	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.87253732
15	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.85290381
16	Antigen processing and presentation_Homo sapiens_hsa04612	1.83749738
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.72186633
18	Parkinsons disease_Homo sapiens_hsa05012	1.71812582
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.65757965
20	Morphine addiction_Homo sapiens_hsa05032	1.64825807
21	Nicotine addiction_Homo sapiens_hsa05033	1.64505129
22	Oxidative phosphorylation_Homo sapiens_hsa00190	1.64061790
23	Tight junction_Homo sapiens_hsa04530	1.54422703
24	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.43880022
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.43117884
26	Cocaine addiction_Homo sapiens_hsa05030	1.42498873
27	Spliceosome_Homo sapiens_hsa03040	1.41752668
28	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.38725162
29	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.31220898
30	Vibrio cholerae infection_Homo sapiens_hsa05110	1.30331328
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.29070329
32	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.28652982
33	Alzheimers disease_Homo sapiens_hsa05010	1.23556585
34	Circadian entrainment_Homo sapiens_hsa04713	1.19515510
35	Huntingtons disease_Homo sapiens_hsa05016	1.18066404
36	Salivary secretion_Homo sapiens_hsa04970	1.17136968
37	Circadian rhythm_Homo sapiens_hsa04710	1.16311823
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.05989815
39	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.05651148
40	Oocyte meiosis_Homo sapiens_hsa04114	1.05063279
41	Axon guidance_Homo sapiens_hsa04360	1.02010261
42	Cholinergic synapse_Homo sapiens_hsa04725	0.97938045
43	mRNA surveillance pathway_Homo sapiens_hsa03015	0.94800184
44	RNA polymerase_Homo sapiens_hsa03020	0.94707040
45	Gap junction_Homo sapiens_hsa04540	0.91309412
46	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.88583439
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.88216240
48	Phototransduction_Homo sapiens_hsa04744	0.88123934
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86944200
50	Glutathione metabolism_Homo sapiens_hsa00480	0.84031649
51	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.82023571
52	Arginine biosynthesis_Homo sapiens_hsa00220	0.81583030
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.80603554
54	Carbon metabolism_Homo sapiens_hsa01200	0.78678524
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.77875265
56	Gastric acid secretion_Homo sapiens_hsa04971	0.77475330
57	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.74829523
58	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.74564794
59	Long-term depression_Homo sapiens_hsa04730	0.74389989
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.73347499
61	Amphetamine addiction_Homo sapiens_hsa05031	0.70668145
62	Insulin secretion_Homo sapiens_hsa04911	0.69196888
63	Estrogen signaling pathway_Homo sapiens_hsa04915	0.68699687
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.68145557
65	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65020603
66	Phagosome_Homo sapiens_hsa04145	0.63489293
67	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61116299
68	Regulation of autophagy_Homo sapiens_hsa04140	0.60024025
69	Serotonergic synapse_Homo sapiens_hsa04726	0.59707562
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56754103
71	Protein export_Homo sapiens_hsa03060	0.54965073
72	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54600661
73	Endocytosis_Homo sapiens_hsa04144	0.54324733
74	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.53352083
75	Wnt signaling pathway_Homo sapiens_hsa04310	0.52104962
76	Long-term potentiation_Homo sapiens_hsa04720	0.51517379
77	MAPK signaling pathway_Homo sapiens_hsa04010	0.51203919
78	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.50751518
79	Alcoholism_Homo sapiens_hsa05034	0.50354815
80	Ribosome_Homo sapiens_hsa03010	0.47753333
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47254872
82	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46110743
83	Glucagon signaling pathway_Homo sapiens_hsa04922	0.46079355
84	Taste transduction_Homo sapiens_hsa04742	0.45879933
85	Toxoplasmosis_Homo sapiens_hsa05145	0.45429583
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43092863
87	Adherens junction_Homo sapiens_hsa04520	0.40798034
88	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40483841
89	Sulfur relay system_Homo sapiens_hsa04122	0.40165155
90	Olfactory transduction_Homo sapiens_hsa04740	0.38422035
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38376865
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.38274351
93	Renin secretion_Homo sapiens_hsa04924	0.37986333
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.36912721
95	Melanogenesis_Homo sapiens_hsa04916	0.35805676
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.35270567
97	Leishmaniasis_Homo sapiens_hsa05140	0.32354884
98	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.29592075
99	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.29064536
100	RNA transport_Homo sapiens_hsa03013	0.28379178

TUBB4BP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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