ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	multicellular organism reproduction (GO:0032504)	8.39837640
2	meiotic cell cycle (GO:0051321)	8.25589201
3	piRNA metabolic process (GO:0034587)	8.23148141
4	oocyte development (GO:0048599)	7.81337526
5	protein kinase C signaling (GO:0070528)	7.23207335
6	positive regulation of histone H3-K4 methylation (GO:0051571)	7.21830057
7	retinal cone cell development (GO:0046549)	7.09751577
8	regulation of meiosis I (GO:0060631)	7.09548373
9	regulation of histone H3-K9 methylation (GO:0051570)	6.79809776
10	positive regulation of humoral immune response (GO:0002922)	6.63206900
11	negative regulation of reproductive process (GO:2000242)	6.57610412
12	DNA methylation involved in gamete generation (GO:0043046)	6.49659563
13	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	6.35762101
14	female gamete generation (GO:0007292)	6.13273554
15	negative regulation of histone methylation (GO:0031061)	5.80328569
16	regulation of steroid hormone secretion (GO:2000831)	5.67665248
17	mitotic chromosome condensation (GO:0007076)	5.63600593
18	reproduction (GO:0000003)	5.61366571
19	glycine transport (GO:0015816)	5.59393913
20	regulation of cell maturation (GO:1903429)	5.32158491
21	gene silencing by RNA (GO:0031047)	4.92296419
22	protein localization to kinetochore (GO:0034501)	4.78788908
23	protein localization to chromosome, centromeric region (GO:0071459)	4.78001325
24	binding of sperm to zona pellucida (GO:0007339)	4.76151494
25	positive regulation of gastrulation (GO:2000543)	4.72228579
26	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.60770034
27	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.60770034
28	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.60770034
29	citrulline biosynthetic process (GO:0019240)	4.60213732
30	positive regulation of reproductive process (GO:2000243)	4.52347625
31	attachment of spindle microtubules to kinetochore (GO:0008608)	4.48822535
32	positive regulation of histone methylation (GO:0031062)	4.44830223
33	regulation of steroid hormone biosynthetic process (GO:0090030)	4.37768996
34	mitotic metaphase plate congression (GO:0007080)	4.36921307
35	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.33640936
36	centriole replication (GO:0007099)	4.27789588
37	fertilization (GO:0009566)	4.25967794
38	regulation of histone H3-K4 methylation (GO:0051569)	4.24267967
39	positive regulation of chromosome segregation (GO:0051984)	4.23846324
40	single fertilization (GO:0007338)	4.12920626
41	primitive streak formation (GO:0090009)	4.11951982
42	regulation of meiosis (GO:0040020)	4.03412729
43	establishment of chromosome localization (GO:0051303)	4.01026397
44	L-amino acid import (GO:0043092)	3.99075943
45	phosphorelay signal transduction system (GO:0000160)	3.93591696
46	regulation of histone methylation (GO:0031060)	3.92143025
47	DNA alkylation (GO:0006305)	3.86367647
48	DNA methylation (GO:0006306)	3.86367647
49	regulation of calcium ion-dependent exocytosis (GO:0017158)	3.86254844
50	regulation of spindle organization (GO:0090224)	3.85133911
51	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.81937923
52	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.81569837
53	regulation of reproductive process (GO:2000241)	3.79492740
54	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.76431592
55	synapsis (GO:0007129)	3.76144466
56	sperm-egg recognition (GO:0035036)	3.70827022
57	negative regulation of hormone biosynthetic process (GO:0032353)	3.68848876
58	negative regulation of hormone metabolic process (GO:0032351)	3.55549758
59	metaphase plate congression (GO:0051310)	3.51250489
60	stress granule assembly (GO:0034063)	3.48889204
61	N-terminal protein amino acid acetylation (GO:0006474)	3.48655639
62	synaptonemal complex assembly (GO:0007130)	3.48526440
63	regulation of hypersensitivity (GO:0002883)	3.46812528
64	negative regulation of histone modification (GO:0031057)	3.46436872
65	gene silencing (GO:0016458)	3.45829017
66	protein localization to chromosome (GO:0034502)	3.44561018
67	negative regulation of execution phase of apoptosis (GO:1900118)	3.43153607
68	histone H3-K9 demethylation (GO:0033169)	3.41381522
69	male meiosis I (GO:0007141)	3.40593001
70	DNA replication-dependent nucleosome assembly (GO:0006335)	3.36115222
71	DNA replication-dependent nucleosome organization (GO:0034723)	3.36115222
72	CENP-A containing nucleosome assembly (GO:0034080)	3.33753993
73	type B pancreatic cell development (GO:0003323)	3.32093087
74	regulation of meiotic cell cycle (GO:0051445)	3.31169219
75	chromatin assembly (GO:0031497)	3.30581707
76	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.28927848
77	interkinetic nuclear migration (GO:0022027)	3.27635825
78	regulation of corticosteroid hormone secretion (GO:2000846)	3.27626927
79	oogenesis (GO:0048477)	3.25481919
80	chromosome organization involved in meiosis (GO:0070192)	3.24167818
81	regulation of chromatin silencing (GO:0031935)	3.24049816
82	DNA replication checkpoint (GO:0000076)	3.22403142
83	positive regulation of hormone biosynthetic process (GO:0046886)	3.21112419
84	regulation of RNA export from nucleus (GO:0046831)	3.19801255
85	regulation of phospholipid biosynthetic process (GO:0071071)	3.16309545
86	regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:0043	3.15792325
87	regulation of G2/M transition of mitotic cell cycle (GO:0010389)	3.15449723
88	translesion synthesis (GO:0019985)	3.14144908
89	histone phosphorylation (GO:0016572)	3.11454710
90	male meiosis (GO:0007140)	3.11101312
91	positive regulation of meiosis (GO:0045836)	3.08795989
92	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.07445865
93	synaptonemal complex organization (GO:0070193)	3.07349717
94	negative regulation of chromatin modification (GO:1903309)	3.06746015
95	regulation of spindle checkpoint (GO:0090231)	3.05748759
96	labyrinthine layer development (GO:0060711)	3.04670247
97	positive regulation of DNA-dependent DNA replication (GO:2000105)	3.02273615
98	regulation of female gonad development (GO:2000194)	10.9019975
99	regulation of acrosome reaction (GO:0060046)	10.8431969
100	regulation of DNA methylation (GO:0044030)	10.7872760

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.99567408
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.84595290
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.71919621
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.69804310
5	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.92320891
6	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.92320891
7	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.92320891
8	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.73573132
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.69672940
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.52919072
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.29623441
12	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.29505171
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.25897498
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.07855635
15	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.06887392
16	EZH2_22144423_ChIP-Seq_EOC_Human	16.7037409
17	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.86606634
18	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.78172739
19	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.76615320
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68999604
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.67998502
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.62443608
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56304436
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.54917293
25	AR_21909140_ChIP-Seq_LNCAP_Human	1.50078727
26	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.49495090
27	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.41477156
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.29235749
29	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.24383042
30	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.20304933
31	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12469568
32	TCF4_23295773_ChIP-Seq_U87_Human	1.11243990
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.09647353
34	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09647353
35	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.07546598
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06135781
37	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.05703498
38	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02775282
39	AR_25329375_ChIP-Seq_VCAP_Human	1.01475652
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01318754
41	GF1_26923725_Chip-Seq_HPCs_Mouse	0.98255975
42	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.97440758
43	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96290953
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.94389269
45	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.94389269
46	SMAD4_21799915_ChIP-Seq_A2780_Human	0.93149179
47	RUNX2_22187159_ChIP-Seq_PCA_Human	0.92357702
48	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92096907
49	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.91939946
50	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90180582
51	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.89474353
52	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.89460542
53	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.89356738
54	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.86887738
55	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.85649709
56	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.84331633
57	CBP_21632823_ChIP-Seq_H3396_Human	0.83742698
58	STAT3_23295773_ChIP-Seq_U87_Human	0.80687725
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.80383482
60	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.80274876
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.79063658
62	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.77985535
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.77268464
64	KLF4_19829295_ChIP-Seq_ESCs_Human	0.76386416
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.75041342
66	SMRT_27268052_Chip-Seq_Bcells_Human	0.73981713
67	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.73466182
68	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.72681059
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.71780625
70	AHR_22903824_ChIP-Seq_MCF-7_Human	0.71011496
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.69687144
72	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.68717528
73	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.68513005
74	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.67302614
75	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.66295082
76	EWS_26573619_Chip-Seq_HEK293_Human	0.65914875
77	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.65682221
78	HTT_18923047_ChIP-ChIP_STHdh_Human	0.65509593
79	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.65225857
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.64753294
81	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.63327267
82	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.62583284
83	TP53_22573176_ChIP-Seq_HFKS_Human	0.62415318
84	REST_21632747_ChIP-Seq_MESCs_Mouse	0.61988054
85	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.61944711
86	DROSHA_22980978_ChIP-Seq_HELA_Human	0.60531427
87	ZNF274_21170338_ChIP-Seq_K562_Hela	0.60384049
88	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.59967110
89	CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.59757709
90	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.59519912
91	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.59197473
92	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.58925124
93	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.58627930
94	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.57986023
95	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.57703449
96	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.57379729
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.57099164
98	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.56950932
99	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.56762485
100	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.56528828

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	8.66435070
2	MP0006292_abnormal_olfactory_placode	4.68193429
3	MP0008877_abnormal_DNA_methylation	4.08499930
4	MP0008789_abnormal_olfactory_epithelium	3.88755262
5	MP0005394_taste/olfaction_phenotype	3.52645696
6	MP0005499_abnormal_olfactory_system	3.52645696
7	MP0005395_other_phenotype	3.51754937
8	MP0008057_abnormal_DNA_replication	3.39499404
9	MP0002139_abnormal_hepatobiliary_system	3.15944820
10	MP0003890_abnormal_embryonic-extraembry	3.06363837
11	MP0003693_abnormal_embryo_hatching	2.99310394
12	MP0003699_abnormal_female_reproductive	2.69784937
13	MP0002138_abnormal_hepatobiliary_system	2.64230280
14	MP0005360_urolithiasis	2.55491815
15	MP0003879_abnormal_hair_cell	2.53044437
16	MP0010030_abnormal_orbit_morphology	2.41771146
17	MP0010234_abnormal_vibrissa_follicle	2.35536004
18	MP0001929_abnormal_gametogenesis	2.34397225
19	MP0002234_abnormal_pharynx_morphology	2.12553266
20	MP0008058_abnormal_DNA_repair	2.11709424
21	MP0003077_abnormal_cell_cycle	2.06693964
22	MP0002210_abnormal_sex_determination	2.06305645
23	MP0003183_abnormal_peptide_metabolism	1.95012858
24	MP0010094_abnormal_chromosome_stability	1.90979309
25	MP0003950_abnormal_plasma_membrane	1.87683141
26	MP0000566_synostosis	1.77940706
27	MP0002161_abnormal_fertility/fecundity	1.71668235
28	MP0000653_abnormal_sex_gland	1.71227067
29	MP0003111_abnormal_nucleus_morphology	1.69131783
30	MP0009840_abnormal_foam_cell	1.68466048
31	MP0010307_abnormal_tumor_latency	1.60720428
32	MP0003121_genomic_imprinting	1.59595792
33	MP0005410_abnormal_fertilization	1.53185542
34	MP0001730_embryonic_growth_arrest	1.49257431
35	MP0001119_abnormal_female_reproductive	1.49174449
36	MP0010368_abnormal_lymphatic_system	1.48128138
37	MP0005646_abnormal_pituitary_gland	1.35778455
38	MP0002160_abnormal_reproductive_system	1.34347608
39	MP0001293_anophthalmia	1.32033479
40	MP0000631_abnormal_neuroendocrine_gland	1.29651527
41	MP0008932_abnormal_embryonic_tissue	1.29114873
42	MP0001145_abnormal_male_reproductive	1.21314942
43	MP0003252_abnormal_bile_duct	1.15855584
44	MP0000762_abnormal_tongue_morphology	1.15048585
45	MP0005389_reproductive_system_phenotype	1.14721546
46	MP0002233_abnormal_nose_morphology	1.10067424
47	MP0000427_abnormal_hair_cycle	1.09753097
48	MP0009379_abnormal_foot_pigmentation	1.08213917
49	MP0005647_abnormal_sex_gland	1.07234165
50	MP0004142_abnormal_muscle_tone	1.04264718
51	MP0003698_abnormal_male_reproductive	1.03188329
52	MP0001672_abnormal_embryogenesis/_devel	1.02937960
53	MP0005380_embryogenesis_phenotype	1.02937960
54	MP0001986_abnormal_taste_sensitivity	0.96599459
55	MP0006276_abnormal_autonomic_nervous	0.95074881
56	MP0002272_abnormal_nervous_system	0.94544099
57	MP0003119_abnormal_digestive_system	0.94163229
58	MP0003136_yellow_coat_color	0.93127783
59	MP0001664_abnormal_digestion	0.92520717
60	MP0000350_abnormal_cell_proliferation	0.90221363
61	MP0010678_abnormal_skin_adnexa	0.89776688
62	MP0001984_abnormal_olfaction	0.85366615
63	MP0001666_abnormal_nutrient_absorption	0.82368190
64	MP0005085_abnormal_gallbladder_physiolo	0.79893600
65	MP0000049_abnormal_middle_ear	0.75718219
66	MP0003868_abnormal_feces_composition	0.75702954
67	MP0000678_abnormal_parathyroid_gland	0.74316900
68	MP0005551_abnormal_eye_electrophysiolog	0.73641299
69	MP0001324_abnormal_eye_pigmentation	0.70232703
70	MP0003941_abnormal_skin_development	0.67496299
71	MP0001502_abnormal_circadian_rhythm	0.66554595
72	MP0004957_abnormal_blastocyst_morpholog	0.64099339
73	MP0002084_abnormal_developmental_patter	0.63083717
74	MP0000015_abnormal_ear_pigmentation	0.60444432
75	MP0002127_abnormal_cardiovascular_syste	0.57981418
76	MP0002089_abnormal_postnatal_growth/wei	0.57981412
77	MP0001963_abnormal_hearing_physiology	0.57053006
78	MP0001919_abnormal_reproductive_system	0.56426671
79	MP0005076_abnormal_cell_differentiation	0.55833272
80	MP0003959_abnormal_lean_body	0.54102307
81	MP0002796_impaired_skin_barrier	0.53376631
82	MP0005501_abnormal_skin_physiology	0.51806873
83	MP0005075_abnormal_melanosome_morpholog	0.51270883
84	MP0005409_darkened_coat_color	0.47178752
85	MP0002085_abnormal_embryonic_tissue	0.46800048
86	MP0000733_abnormal_muscle_development	0.45157579
87	MP0003935_abnormal_craniofacial_develop	0.43175716
88	MP0001697_abnormal_embryo_size	0.41800625
89	MP0002873_normal_phenotype	0.40990186
90	MP0002169_no_abnormal_phenotype	0.40450663
91	MP0003984_embryonic_growth_retardation	0.39951911
92	MP0000428_abnormal_craniofacial_morphol	0.39573713
93	MP0003755_abnormal_palate_morphology	0.39535672
94	MP0004043_abnormal_pH_regulation	0.39410538
95	MP0004381_abnormal_hair_follicle	0.38693163
96	MP0002090_abnormal_vision	0.38676195
97	MP0005319_abnormal_enzyme/_coenzyme	0.38650162
98	MP0002928_abnormal_bile_duct	0.38587447
99	MP0008995_early_reproductive_senescence	0.38045968
100	MP0001881_abnormal_mammary_gland	0.36876253

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	6.14404890
2	Hypoplasia of the fovea (HP:0007750)	5.33307566
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.33307566
4	Abdominal situs inversus (HP:0003363)	5.30783020
5	Abnormality of abdominal situs (HP:0011620)	5.30783020
6	Male infertility (HP:0003251)	5.21379451
7	Impulsivity (HP:0100710)	5.18339520
8	Anterior segment dysgenesis (HP:0007700)	5.17762420
9	Osteomalacia (HP:0002749)	5.12156732
10	Lip pit (HP:0100267)	5.01749294
11	Supernumerary spleens (HP:0009799)	4.77565833
12	Abnormal gallbladder physiology (HP:0012438)	4.72445084
13	Cholecystitis (HP:0001082)	4.72445084
14	Facial hemangioma (HP:0000329)	4.61406519
15	Papillary thyroid carcinoma (HP:0002895)	4.46271277
16	Abnormality of the fovea (HP:0000493)	4.45319728
17	Hypophosphatemic rickets (HP:0004912)	4.40996397
18	Infertility (HP:0000789)	4.11434609
19	Septo-optic dysplasia (HP:0100842)	3.96399255
20	Oligodactyly (hands) (HP:0001180)	3.70909147
21	Chromsome breakage (HP:0040012)	3.69872926
22	Apathy (HP:0000741)	3.66207396
23	Azoospermia (HP:0000027)	3.58196860
24	Premature ovarian failure (HP:0008209)	3.57984292
25	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.57223691
26	Diminished motivation (HP:0000745)	3.52836252
27	Hypokinesia (HP:0002375)	3.46288242
28	Aplasia/Hypoplasia of the macula (HP:0008059)	3.40093238
29	Median cleft lip (HP:0000161)	3.39196489
30	Malnutrition (HP:0004395)	3.25174480
31	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	3.17763066
32	Aplasia/Hypoplasia affecting the retina (HP:0008061)	3.11467142
33	Gonadotropin excess (HP:0000837)	3.06879353
34	Absent septum pellucidum (HP:0001331)	3.02048767
35	Truncal obesity (HP:0001956)	2.82554829
36	Capillary hemangiomas (HP:0005306)	2.81777459
37	Spinal cord compression (HP:0002176)	2.79546131
38	Lower limb hyperreflexia (HP:0002395)	2.76357226
39	Short tibia (HP:0005736)	2.75003604
40	Abnormality of the labia minora (HP:0012880)	2.73974782
41	Aplasia of the musculature (HP:0100854)	2.73178129
42	Oligodactyly (HP:0012165)	2.71833325
43	Abnormal spermatogenesis (HP:0008669)	2.70866507
44	Urethral obstruction (HP:0000796)	2.54734542
45	Myokymia (HP:0002411)	2.53397139
46	Abnormality of the septum pellucidum (HP:0007375)	2.50899285
47	Metaphyseal irregularity (HP:0003025)	2.50779914
48	Muscle stiffness (HP:0003552)	2.48648290
49	Skin pits (HP:0100276)	2.47782787
50	Posterior subcapsular cataract (HP:0007787)	2.46569795
51	Striae distensae (HP:0001065)	2.46330428
52	Loss of speech (HP:0002371)	2.45762324
53	Thyroid carcinoma (HP:0002890)	2.44329270
54	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.40380155
55	Dysdiadochokinesis (HP:0002075)	2.34328499
56	Hypergonadotropic hypogonadism (HP:0000815)	2.31877188
57	Conjunctival telangiectasia (HP:0000524)	2.30635236
58	Enlarged penis (HP:0000040)	2.26464139
59	Anhidrosis (HP:0000970)	2.21405639
60	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.19692676
61	Wrist flexion contracture (HP:0001239)	2.19429686
62	Proximal tubulopathy (HP:0000114)	2.17869160
63	Abnormality of the anterior chamber (HP:0000593)	2.17522607
64	Generalized aminoaciduria (HP:0002909)	2.16243641
65	Congenital sensorineural hearing impairment (HP:0008527)	2.16187149
66	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.15771600
67	Subcapsular cataract (HP:0000523)	2.13563393
68	Bundle branch block (HP:0011710)	2.13092149
69	Intrahepatic cholestasis (HP:0001406)	2.12998552
70	Maternal diabetes (HP:0009800)	2.11246947
71	Increased circulating renin level (HP:0000848)	2.08201143
72	Fair hair (HP:0002286)	2.05085143
73	Hypercortisolism (HP:0001578)	1.99709797
74	Abnormal ciliary motility (HP:0012262)	1.97166482
75	Abnormal biliary tract physiology (HP:0012439)	1.96657793
76	Bile duct proliferation (HP:0001408)	1.96657793
77	Abnormality of calcium-phosphate metabolism (HP:0100530)	1.94642263
78	Nephroblastoma (Wilms tumor) (HP:0002667)	1.94572387
79	Heterotopia (HP:0002282)	1.92590915
80	Abnormality of chromosome stability (HP:0003220)	1.90318046
81	Sensory axonal neuropathy (HP:0003390)	1.89227899
82	Microglossia (HP:0000171)	1.89036458
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.85158791
84	Abnormal lung lobation (HP:0002101)	1.84510397
85	Embryonal renal neoplasm (HP:0011794)	1.83684848
86	Secondary amenorrhea (HP:0000869)	1.82228827
87	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.81982831
88	Stillbirth (HP:0003826)	1.79348499
89	Broad alveolar ridges (HP:0000187)	1.78517449
90	Small intestinal stenosis (HP:0012848)	1.78000638
91	Duodenal stenosis (HP:0100867)	1.78000638
92	Neoplasm of the oral cavity (HP:0100649)	1.75322264
93	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.75317232
94	Abnormality of the preputium (HP:0100587)	1.75062680
95	Rickets (HP:0002748)	1.73545741
96	Cleft eyelid (HP:0000625)	1.73177981
97	Abnormality of the phalanges of the hallux (HP:0010057)	1.72904850
98	Meckel diverticulum (HP:0002245)	1.71894389
99	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.67526259
100	Hip contracture (HP:0003273)	1.65781471

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	6.36984711
2	MAP3K13	5.68838051
3	ARAF	5.62286002
4	TAOK3	3.28061611
5	NEK6	3.27576391
6	CDK12	3.21407375
7	TTK	3.01891230
8	STK24	2.97483398
9	BRAF	2.79384764
10	MOS	2.47624481
11	AURKA	2.45032108
12	CDC7	2.21636877
13	MET	2.12161745
14	CDK9	1.97418797
15	KSR2	1.83489741
16	NTRK2	1.79332165
17	RAF1	1.77336066
18	TRIM28	1.62367227
19	PRKCI	1.61802996
20	MELK	1.59746172
21	CDK7	1.51497477
22	BUB1	1.44268629
23	TNIK	1.39878460
24	PLK1	1.34197388
25	EIF2AK3	1.28231366
26	STK3	1.21101328
27	BRSK1	1.20593371
28	KSR1	1.13882985
29	PTK2	1.13288594
30	CDK19	1.09691218
31	CHEK1	0.98512446
32	PIM1	0.95598009
33	MAP3K8	0.94880160
34	NEK2	0.93874253
35	WNK1	0.91290532
36	TNK2	0.87600564
37	CDK8	0.81766171
38	MARK3	0.77255618
39	CDK2	0.76475031
40	AURKB	0.74914270
41	NUAK1	0.74704751
42	ZAK	0.74090353
43	CSNK1G1	0.73402283
44	MST4	0.70621483
45	DMPK	0.69952202
46	PLK3	0.68722517
47	CHEK2	0.68643552
48	MAPKAPK3	0.68368319
49	TGFBR1	0.67396972
50	ATM	0.65682495
51	MTOR	0.65329349
52	EEF2K	0.62790193
53	PAK1	0.61309169
54	BMPR1B	0.60945662
55	CAMK1D	0.58788914
56	TIE1	0.56913728
57	CSNK1D	0.56797212
58	NTRK3	0.54570040
59	PRKG1	0.54024952
60	CDK1	0.53704566
61	PRKCZ	0.52435615
62	BRSK2	0.50162741
63	NEK9	0.48589929
64	STK39	0.48276569
65	CSNK1E	0.47651903
66	SRPK1	0.47569750
67	CSNK1G3	0.45518117
68	PKN1	0.45452703
69	MAPK13	0.44475126
70	LRRK2	0.44421387
71	ATR	0.44362457
72	MAP3K5	0.41219381
73	CDK5	0.37351113
74	PDK1	0.35562931
75	PRKACB	0.31263885
76	VRK1	0.30474736
77	GSK3B	0.30357152
78	CAMK1G	0.29969412
79	CSNK1A1L	0.29823572
80	TYRO3	0.28003550
81	CAMK2A	0.27265457
82	BRD4	0.26933800
83	CHUK	0.26277213
84	MARK2	0.26055284
85	MAPK11	0.24982239
86	PRKACA	0.24978729
87	MAPK1	0.24828334
88	CSNK1G2	0.24469588
89	EPHA4	0.24302427
90	AKT2	0.23667101
91	MAPK10	0.23468587
92	TLK1	0.22187563
93	ACVR1B	0.21070914
94	PBK	0.20422910
95	MAP3K4	0.20311009
96	TESK2	0.20215080
97	PDPK1	0.18579754
98	TRPM7	0.18137035
99	CLK1	0.16505449
100	MAP3K7	0.14516545

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	5.31256001
2	Cell cycle_Homo sapiens_hsa04110	4.45188928
3	Ovarian steroidogenesis_Homo sapiens_hsa04913	4.00270569
4	Mismatch repair_Homo sapiens_hsa03430	3.73471871
5	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.43175145
6	Oocyte meiosis_Homo sapiens_hsa04114	3.36154629
7	Base excision repair_Homo sapiens_hsa03410	2.93794960
8	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.75763121
9	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.70342533
10	Caffeine metabolism_Homo sapiens_hsa00232	2.69500999
11	RNA degradation_Homo sapiens_hsa03018	2.64617562
12	DNA replication_Homo sapiens_hsa03030	2.39579516
13	Nucleotide excision repair_Homo sapiens_hsa03420	2.29149505
14	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.25466195
15	Fanconi anemia pathway_Homo sapiens_hsa03460	2.15613456
16	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.15518597
17	Homologous recombination_Homo sapiens_hsa03440	2.01745502
18	RNA transport_Homo sapiens_hsa03013	1.88848799
19	Circadian rhythm_Homo sapiens_hsa04710	1.87395907
20	Olfactory transduction_Homo sapiens_hsa04740	1.85937309
21	p53 signaling pathway_Homo sapiens_hsa04115	1.81251278
22	Gap junction_Homo sapiens_hsa04540	1.65592484
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.56881687
24	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.51246249
25	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.42740081
26	Phototransduction_Homo sapiens_hsa04744	1.40303450
27	Thyroid cancer_Homo sapiens_hsa05216	1.38599725
28	mRNA surveillance pathway_Homo sapiens_hsa03015	1.36049635
29	Folate biosynthesis_Homo sapiens_hsa00790	1.29294458
30	RNA polymerase_Homo sapiens_hsa03020	1.19441582
31	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.14197347
32	ABC transporters_Homo sapiens_hsa02010	1.04437128
33	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.92720180
34	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.92029415
35	Bile secretion_Homo sapiens_hsa04976	0.90445683
36	mTOR signaling pathway_Homo sapiens_hsa04150	0.87929093
37	Morphine addiction_Homo sapiens_hsa05032	0.86464916
38	Taste transduction_Homo sapiens_hsa04742	0.85942924
39	Nicotine addiction_Homo sapiens_hsa05033	0.83613410
40	GABAergic synapse_Homo sapiens_hsa04727	0.79545515
41	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79235588
42	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.72814188
43	FoxO signaling pathway_Homo sapiens_hsa04068	0.69666208
44	MicroRNAs in cancer_Homo sapiens_hsa05206	0.68651269
45	Adherens junction_Homo sapiens_hsa04520	0.64656734
46	Fatty acid elongation_Homo sapiens_hsa00062	0.64534264
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60066174
48	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.57919534
49	Purine metabolism_Homo sapiens_hsa00230	0.56651009
50	Serotonergic synapse_Homo sapiens_hsa04726	0.54290408
51	Long-term depression_Homo sapiens_hsa04730	0.54248245
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52598689
53	Viral carcinogenesis_Homo sapiens_hsa05203	0.50824140
54	Herpes simplex infection_Homo sapiens_hsa05168	0.49105424
55	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.46763930
56	Notch signaling pathway_Homo sapiens_hsa04330	0.42976624
57	Wnt signaling pathway_Homo sapiens_hsa04310	0.40634460
58	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.37147025
59	Hippo signaling pathway_Homo sapiens_hsa04390	0.34646600
60	Small cell lung cancer_Homo sapiens_hsa05222	0.33805405
61	ErbB signaling pathway_Homo sapiens_hsa04012	0.32602502
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.32257785
63	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.31214099
64	Lysine degradation_Homo sapiens_hsa00310	0.31184557
65	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.30556065
66	Ras signaling pathway_Homo sapiens_hsa04014	0.28496279
67	Endometrial cancer_Homo sapiens_hsa05213	0.27319785
68	HTLV-I infection_Homo sapiens_hsa05166	0.25969904
69	Spliceosome_Homo sapiens_hsa03040	0.21865111
70	Protein digestion and absorption_Homo sapiens_hsa04974	0.21669297
71	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.21667612
72	Cholinergic synapse_Homo sapiens_hsa04725	0.21466907
73	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21425428
74	cAMP signaling pathway_Homo sapiens_hsa04024	0.21383983
75	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.21094047
76	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.20388583
77	Regulation of autophagy_Homo sapiens_hsa04140	0.20339026
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.19930588
79	Phagosome_Homo sapiens_hsa04145	0.18993359
80	Huntingtons disease_Homo sapiens_hsa05016	0.18522755
81	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.18412178
82	Long-term potentiation_Homo sapiens_hsa04720	0.13155579
83	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.12589164
84	Amoebiasis_Homo sapiens_hsa05146	0.11896099
85	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.11749109
86	Influenza A_Homo sapiens_hsa05164	0.11250415
87	Renal cell carcinoma_Homo sapiens_hsa05211	0.11006022
88	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.10955104
89	Circadian entrainment_Homo sapiens_hsa04713	0.10899345
90	Prostate cancer_Homo sapiens_hsa05215	0.10288204
91	Insulin secretion_Homo sapiens_hsa04911	0.10245772
92	Non-small cell lung cancer_Homo sapiens_hsa05223	0.09706403
93	Non-homologous end-joining_Homo sapiens_hsa03450	0.09573856
94	Tight junction_Homo sapiens_hsa04530	0.09163422
95	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.09134768
96	Pyrimidine metabolism_Homo sapiens_hsa00240	0.08950522
97	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.08788291
98	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.08630433
99	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.08133426
100	MAPK signaling pathway_Homo sapiens_hsa04010	0.07633286

TUBB7P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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